Simultaneous thermal measurement of multiple samples

JP2026517674APending Publication Date: 2026-06-02THERMOCAP LABORATORIES INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
THERMOCAP LABORATORIES INC
Filing Date
2024-04-10
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Conventional differential scanning calorimeters (DSCs) face limitations in throughput and sample handling, particularly for biological samples, leading to high costs and time-consuming processes due to the need for sequential processing and complex cleaning, which hinders their application as a quantitative tool for molecular interactions.

Method used

A high-throughput modular apparatus with optimized precision is developed, featuring a sample cartridge with multiple wells, modular sample wells, and a sensor system that allows parallel processing and minimizes thermal and electrical interference, enabling accurate and rapid analysis of multiple samples.

Benefits of technology

The apparatus enables rapid, accurate, and cost-effective analysis of multiple samples, reducing processing time from hours to minutes and minimizing errors, thus expanding the applicability of DSC technology for molecular interaction studies.

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Abstract

A multi-sample differential scanning calorimetry (DSC) enables high-throughput sample processing that processes multiple samples simultaneously. The multi-sample DSC comprises a test chamber, sample cartridges located inside the test chamber and positioned around multiple sample wells, multiple temperature sensors, each measuring the temperature of a corresponding sample well, and a processing unit configured to selectively determine the temperature difference between any two or more sample wells.
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