Crystalline form of lipoprotein compounds and method of preparing the same.

By developing crystalline forms A, B, C, D, and E with specific X-ray diffraction patterns and employing stabilization methods, the compound's stability and industrial applicability are improved, addressing issues of amorphous forms with low stability and aggregation.

JP2026517918APending Publication Date: 2026-06-02JIANGSU HENGRUI MEDICINE CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
JIANGSU HENGRUI MEDICINE CO LTD
Filing Date
2024-05-10
Publication Date
2026-06-02

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Abstract

This disclosure relates to the crystalline form of a lipoprotein compound and a method for preparing the same. In particular, this disclosure provides the crystalline form of (2S)-3-(3-{[(2-{3-[(2S)-2-carboxyl-2-[(3R)-pyrrolidine-3-yl]ethyl]phenoxy}ethyl)({3[(2S)-2-carboxyl-2-[(3R)-pyrrolidine-3-yl]ethyl]phenyl}methyl)amino]methyl}phenyl)-2-[(3R)-pyrrolidine-3-yl]propionic acid and a method for preparing the same.
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