Ultrasonic coupling agent
An aqueous ultrasonic coupling agent with triglycerides and phospholipids addresses brightness artifacts in invasive imaging by matching sound attenuation, enhancing image clarity and accuracy.
JP2026518062APending Publication Date: 2026-06-03ソノクリアー アーエス
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Patent Information
- Application Number
- JP2025568752
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-05-24
- Filing Date
- 2024-05-24
- Publication Date
- 2026-06-03
AI Technical Summary
Technical Problem
Ultrasonic imaging during invasive procedures, such as brain tumor surgery, is hindered by brightness artifacts caused by the difference in sound attenuation between fluid-filled cavities and surrounding biological tissue, leading to inaccurate image interpretation.
Method used
An aqueous ultrasonic coupling agent comprising triglycerides, phospholipids, water, pH buffer, and glycerol, with an attenuation constant of 0.15 to 0.60 dB/(MHz*cm), is used to minimize artifacts by matching sound attenuation with biological tissue.
Benefits of technology
The coupling agent reduces image artifacts, ensuring accurate ultrasound imaging by maintaining consistent sound wave amplitude and reducing intensity fluctuations at tissue interfaces.
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Smart Images
Figure 2026518062000001_ABST
Abstract
This specification provides ultrasound coupling agents and methods for using them in ultrasound imaging of a target. The ultrasound imaging may be invasive ultrasound imaging. Methods for preparing ultrasound coupling agents and methods for formulating ultrasound coupling agents are also provided herein. An aqueous ultrasound coupling agent comprising a) at least one triglyceride in about 60.0 to about 80.0 g / L, b) at least one phospholipid in about 3.2 to about 5.2 g / L, c) water, d) pH buffer, and e) glycerol is described herein, wherein the ultrasound coupling agent has an attenuation constant of about 0.15 dB / (MHz*cm) to about 0.60 dB / (MHz*cm) or about 0.002 to about 1.0 dB / (MHz*cm).
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