Crosslinkable liquid composition for use in treatment methods for eye diseases

A crosslinkable liquid composition using PEGDA and gelatin forms a corneal onlay on the cornea, addressing limitations of refractive laser surgeries by providing a long-term, reversible solution for refractive errors and corneal irregularities with reduced complications.

JP2026518412APending Publication Date: 2026-06-08UNIVERSITEIT ANTWERPEN +1
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
UNIVERSITEIT ANTWERPEN
Filing Date
2024-04-26
Publication Date
2026-06-08

AI Technical Summary

Technical Problem

Existing refractive laser surgeries for correcting refractive errors and corneal irregularities are limited by tissue removal, regression over time, and risks of complications such as corneal thinning and opacity, with subtractive methods failing to provide a wide therapeutic window and long-term efficacy.

Method used

A crosslinkable liquid composition comprising polyethylene glycol diacrylate (PEGDA) and gelatin or gelatin-based biomaterial is applied to the cornea, crosslinked in situ using UV or visible light, forming a corneal onlay that can correct curvature without reducing corneal thickness, offering a long-term and reversible solution.

Benefits of technology

The method provides a wider therapeutic window for correcting refractive errors like hyperopia and presbyopia, reduces postoperative complications, and maintains corneal integrity, ensuring long-term effectiveness without regression.

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Abstract

The present invention relates to a crosslinkable liquid composition for use in a method of treating an eye disease of a subject eye, comprising (i) polyethylene glycol diacrylate (PEGDA), (ii) gelatin or a gelatin-based crosslinkable biomaterial, and (iii) a photoinitiator and optionally a coinitiator, the method comprising applying the crosslinkable liquid composition to the anterior corneal surface of the eye having the eye disease using a mold, crosslinking the crosslinkable liquid composition on the anterior corneal surface of the eye, thereby obtaining a composition crosslinked on the anterior corneal surface of the eye, and correcting the curvature of the crosslinked composition.
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