A holding device for a dispensing device for dispensing at least one therapeutically and / or diagnostically effective substance.

Abstract

Illustrated and described is a dispensing device (2) for dispensing at least one therapeutically and / or diagnostically effective substance, particularly a holding device (1) for an autoinjector. In the present invention, the holding device (1) is embodied as a multiple holder for holding two or more dispensing devices (2) on the holding device (1), and for dispensing substances through at least one dispensing device (2) held on the holding device (1) in a manner that holds the dispensing devices (2).

Description

【Technical Field】 【0001】 The present invention relates to a holding device, particularly for an auto-injector, for a substance delivery device for the delivery of at least one therapeutically and / or diagnostically active substance. The holding device is dimensioned to be held by hand during substance delivery and / or configured for manual use. 【0002】 Furthermore, the present invention relates to a device having a holding device and a substance delivery device for the delivery of at least one therapeutically and / or diagnostically active substance, particularly an auto-injector. 【0003】 Furthermore, the present invention relates to the use of a holding device for holding at least one substance delivery device, particularly an auto-injector, for the delivery of at least one therapeutically and / or diagnostically active substance. 【0004】 Finally, the present invention relates to a method for the multiple application of therapeutically and / or diagnostically active substances by substance delivery through two or more substance delivery devices, particularly two or more auto-injectors. 【0005】 The present invention relates to the handling and / or use of a delivery device for the delivery of therapeutically and / or diagnostically active substances. 【Background Art】 【0006】 Material dispensing devices are known from the prior art, structurally and functionally configured and embodied for self-sufficient material dispensing. For this purpose, dispensing devices have a structured unit configured and embodied for material dispensing in a structurally and functionally independent manner. In particular, dispensing devices have an outer housing, which allows the dispensing device to be held through the outer housing during material dispensing and independently of individual holding devices, and can be positioned and handled relative to the material dispensing site, particularly the patient's injection site. Furthermore, in particular, dispensing devices are equipped with a trigger mechanism, which independently triggers material dispensing and / or material release after activation of the actuator of the trigger mechanism. 【0007】 In particular, the dispensing device may include an assembly integrated into or enclosed within the dispensing device for needle assistance or needle-free dispensing of substances to a patient. The housing of the dispensing device may be a functional component of the assembly, i.e., it may be able to mechanically and functionally interact with other parts of the assembly during injection, or simply to enclose / wrap the assembly and contribute to handling the assembly during substance dispensing. By integrating and / or enclosing the assembly for needle assistance or needle-free substance dispensing within the housing of the dispensing device, the dispensing device can be used in a simple manner, i.e., independently of other assemblies, and in particular independently of a separate holding device for the dispensing device. 【0008】 In particular, dispensing devices are designed and functionalized for single injections of therapeutically and / or diagnostically effective substances. However, the use of dispensing devices designed and functionalized for multiple substance dispensing, especially for multiple injections, is not excluded. 【0009】 The dispensing device can be an auto-injector in particular. Suitable auto-injectors that can be used within the scope of the present invention are described, for example, in EP 2 742 962 A2, EP 2 745 866 A1, or CH 711 066 A2. The above documents describe auto-injectors configured and functionalized for self-sufficient dispensing of substances and that can be used within the scope of the present invention. 【0010】 EP 2 742 962 A2 describes an autosyringe configured for self-sufficient dispensing of material, for example, equipped with a device for generating acoustic and / or tactile signals. The autosyringe has a sleeve-shaped elongated housing with a longitudinal axis, which has a closing cap at its proximal end, i.e., the rear end or the end opposite the needle of the autosyringe, which is connected to the housing in a manner that is fixed in the rotational and axial directions in a shape-adaptive manner to form the proximal end of the autosyringe. 【0011】 A known automatic syringe may have a pull-out cap positioned at its distal front end in its delivery state, which is pulled out or twisted off before the automatic syringe is used. A syringe-shaped product container may be received in the housing of an automatic syringe so that it is immovable along its longitudinal axis. The product container may have a sleeve-shaped syringe body / syringe barrel, which surrounds a plunger or piston that lies sealed against the inner circumference of the syringe body. At its distal end, the syringe body may have a needle inseparably connected to the syringe body, the distal end of which is formed by the needle tip. A liquid substance, in particular a drug / medicine, may be placed in the syringe body between the needle and the plunger or piston, and the substance is discharged / unsealed from the syringe body through the injection needle by displacing the plunger or piston distally toward the injection needle in a dispensing and / or release direction. The syringe body may be positioned in relation to the housing such that the needle tip protrudes distally beyond the distal end of the housing. 【0012】 In the initial or dispensing state of a known autosyringer, i.e., when the withdrawal cap is positioned on the autosyringer, the needle is covered by a needle protection cap, which may be embodied as a so-called rigid needle shield, or alternatively as a flexible needle shield, known to those skilled in the art, to protect the needle from contamination and keep the material inside the syringe body sterile. The needle protection cap is positioned on the needle-holding portion of the syringe body, and the withdrawal cap is releasably snapped to the housing or to an axially displaceable needle protection sleeve that forms an actuator for triggering the dispensing of material, and this snapping is released when the withdrawal cap is removed from the housing or needle protection sleeve. 【0013】 In known autoinjectors, the needle protection sleeve is displaceable relative to the housing and along the longitudinal axis by a proximal working stroke into the working position to activate the trigger mechanism and trigger substance release. In the initial position before activation of the trigger mechanism, the distal end of the needle protection sleeve protrudes distally over the needle tip so that access to the needle tip is initially prevented. By displacing the needle protection sleeve by a proximal working stroke, the needle protection sleeve is moved proximal enough for the needle to protrude beyond the distal end of the needle protection sleeve, which corresponds to the injection depth of the needle into the patient's puncture site. Preferably, the needle protrudes beyond the distal end of the needle protection sleeve so that subcutaneous injection can be performed. In particular, the housing can form a stop into which the needle protection sleeve is placed in the working position. 【0014】 The withdrawal cap described at the beginning has a snatch / catch that engages with the gap between the syringe body, particularly its tapered region, and the proximal end of the needle protection cap. When the withdrawal cap is removed from the autosyringer, the catch hooks into the gap, thereby allowing the needle protection cap to be detached from the syringe body and removed from the autosyringer together with the withdrawal cap. 【0015】 To administer the substance from the syringe body, the withdrawal cap is withdrawn together with the needle protection cap from a known autosynergy. The distal end of the needle protection sleeve is positioned relative to the patient's puncture site, and the housing is displaced toward the puncture site so that the needle protection sleeve moves from its initial position into the working position by a proximal working stroke relative to the housing. This activates and / or initiates the trigger mechanism, which leads to the release of the substance. The disclosure of the trigger mechanism described in EP 2 742 962 A2 is incorporated within the disclosures herein. 【0016】 After the injection is administered, the needle protection sleeve can move along the longitudinal axis of the housing relative to the housing from the working position to the needle protection position by a distal needle protection stroke. In the needle protection position, the distal end of the needle protection sleeve then protrudes distally over the needle tip, thereby preventing access to the needle tip and reducing the risk of injury. The needle protection sleeve can be prevented from moving back from the needle protection position. 【0017】 The auto-injectors known from EP 2 742 962 A2 represent exemplary embodiments of auto-injectors configured and functionalized for self-sufficient substance dispensing. Such auto-injectors form and / or comprise an integrated structural unit, and the auto-injector assembly required for substance dispensing can be integrated into the outer housing of the auto-injector. Auto-injectors thus embodied are commercially available as standard auto-injectors and are typically held manually with respect to substance dispensing and / or substance dispensing, and moved toward the injection site on the patient, to achieve automatic substance dispensing from the product container of the auto-injector by contact of an actuator, for example, contact of the needle protection sleeve of the auto-injector known from EP 2 742 962 A2. For this purpose, the structural unit integrated within the housing of the auto-injector is configured and functionalized in a corresponding manner. 【0018】 The type of auto-injector described in EP 2 742 962 A2 relates to a preferred embodiment of a dispensing device that can be used in connection with the teachings of the present invention, but the present invention is not limited to the use of such an auto-injector. Dispensing devices configured and embodied for self-sufficient substance dispensing, although their configuration and function differ from those described in EP 2 742 962 A2, can also be advantageously used within the scope of the present invention. 【0019】 Further similar automatic injectors that can also be used within the scope of the present invention are shown and described, for example, in EP 2 745 866 A1 and CH 711 066 A2. The disclosures in documents EP 2 742 962 A2, EP 2 745 866 A1, and CH 711 066 A2 are fully incorporated into the disclosures of the specification of the present invention. 【0020】 To improve the handling of dispensing devices before, during, and after material dispensing, holding devices for holding and / or fastening only one dispensing device to a holding device and for dispensing material through dispensing devices held on a holding device in a holding state are already known from the prior art. 【0021】 Such holding devices are typically used to simplify the handling of dispensing devices for the user of the dispensing device, particularly during the dispensing of substances, especially during the injection of substances into a patient's body, in order to ensure a high level of user comfort when using dispensing devices. For this purpose, such single holders may have a certain surface shape optimized from an ergonomic standpoint and / or a certain surface structure that improves tactile perception of the surface when using the single holder, such as a material made of soft elastic plastic, for example, one or more heat-generating materials that improve static friction. 【0022】 In addition, the appearance and / or design of the single holder may be intended to give the combination of the single holder and the dispensing device an aesthetically pleasing appearance. The single holder may be individualized for use by a particular user and may include means for storing and / or retrieving and / or displaying data and information associated with that user. The holder may also be configured and embodied to measure bodily function values ​​such as temperature, time, or blood glucose and have corresponding measuring devices for this purpose. Finally, the appearance and shape of the single holder may allow differentiation of dispensing devices connected to the single holder with respect to the type and composition of the substance being dispensed and / or with respect to a specific dispensing volume of dispensing devices from dispensing devices having different substances and / or different dispensing volumes, i.e., providing easily recognizable distinguishing means for differentiating different dispensing devices. 【0023】 For example, from EP 3 213 784 B1, a holding device embodied as a single holder having a drug delivery device is known, where the drug delivery device is an auto-injector. The holding device has a shell component having an entry passage through which the auto-injector is introduced into the shell component and then held within the shell component. Yet another shell component is connected to the first shell component and contributes as a closing element that closes the entry passage. The auto-injector is then held between the two shell components and fixed to the shell components through a fixing element. 【0024】 From EP 1 494 740 B1, a U-shaped single holder for a dispensing device for dispensing therapeutically and / or diagnostically effective substances is known, which can be detachably slid on a gripping portion of the housing of the dispensing device and then held on the housing in a fastening manner. The outer surface of this holding device may be provided with means to give the holding device certain tactile characteristics. 【0025】 From EP 2 688 604 A1, a holding device for a syringe is known, which is intended to facilitate the handling of the syringe during injection and has a shell housing formed by two half-shell parts connected to each other in a foldable manner. In the functional state, the syringe is then arranged between the half-shell parts folded on top of each other. 【0026】 From WO 2011 / 124633 A1, it is known to individualize a substance dispensing device by attaching two half-shell parts to the housing of the substance dispensing device and then connecting these to each other such that the dispensing device is fastened and held between the half-shell parts. Next, for example, graphic information contributing to the individualization and differentiation of the dispensing device can be added to the half-shell parts. 【0027】 EP 0 014 006 B1 discloses an injection device comprising an outer housing assembly, in which a first cartridge sub-assembly and a second cartridge sub-assembly are arranged. The outer housing assembly comprises two housing halves connected to each other by rivets. 【0028】 US 2005 / 0203464 A1 discloses a medical injection device for simultaneously administering two or more drugs. The device comprises a housing structured to hold two or more syringes in a fixed relationship. The housing comprises two parts, each part defining a half of the housing, and the first part and the second part are connected to each other using a hinge assembly. 【0029】 WO 2018 / 078121 A1 discloses an injection device for the simultaneous administration of several drugs, the injection device comprising a carrier housing and two cartridges arranged therein. 【Prior Art Documents】 【Patent Documents】 【0030】 [Patent Document 1] EP 2 742 962 A2 [Patent Document 2] EP 2 745 866 A1 [Patent Document 3] CH 711 066 A2 [Patent Document 4] EP 3 213 784 B1 [Patent Document 5] EP 1 494 740 B1 [Patent Document 6] EP 2 688 604 A1 [Patent Document 7] WO 2011 / 124633 A1 [Patent Document 8] EP 0 014 006 B1 [Patent Document 9] US 2005 / 0203464 A1 [Patent Document 10] WO 2018 / 078121 A1 [Summary of the Invention] [Problems to be Solved by the Invention] 【0031】 The object of the present invention is to provide a holding device for a dispensing device for the dispensing of therapeutically and / or diagnostically active substances, which is characterized by an extended functionality compared to known single holders. In particular, the holding device should be suitable for use in combination with at least one dispensing device configured and functionalized for self-sufficient dispensing, in particular for dispensing that is independent of the holding device. 【0032】 Furthermore, the object of the present invention is to provide a device having a holding device characterized by an extended functionality compared to known devices having a single holder and a dispensing device held on the single holder, and having at least one dispensing device for the dispensing of at least one therapeutically and / or diagnostically active substance. 【0033】 A further object of the present invention is to provide a novel and advantageous use of a holding device for holding a dispensing device before, during, and / or after dispensing a substance, and an improved method for multiple applications of therapeutically and / or diagnostically effective substances by dispensing a substance through multiple dispensing devices. 【0034】 The holding device according to the present invention should satisfy high requirements for easy handling of the dispensing device during material dispensing and for the appearance and / or design of the apparatus formed by the holding device and the dispensing device. 【0035】 The holding device according to the present invention should, in particular, enable the dispensing of more substances, especially multiple substances, in a simpler manner compared to dispensing substances using only one dispensing device, without the need to increase the configuration of the dispensing device, especially the size of the volume reservoir of the dispensing device for substances that are therapeutically and / or diagnostically effective. 【0036】 Particularly preferably, the holding device should be suitable for use with already available dispensing devices, especially commercially available auto-injectors, and should be designed / configured to be advantageous for this use. [Means for solving the problem] 【0037】 The above-mentioned objectives are solved by the present invention by a holding device having the features described in claim 1, by an apparatus having the holding device described in claim 13 and at least one dispensing device, by using a holding device for holding at least one dispensing device described in claim 14, or by a method for multiple applications of a therapeutically and / or diagnostically effective substance having the features described in claim 15. Advantageous embodiments of the present invention are the subject of the dependent claims. 【0038】 To address the objectives mentioned above, the present invention proposes a holding device as a multi-holder for holding and / or fastening / securing two or more dispensing devices, particularly two or more automatic syringes, on a multi-holder in a shape-adaptive and / or pressure-fitting manner, and also potentially in a material-fitting / bonding manner. The holding device is embodied and configured with respect to material dispensing through at least one dispensing device held on the holding device, in particular with respect to material dispensing through multiple dispensing devices held on the holding device, and even more particularly with respect to material dispensing through all dispensing devices held on the holding device, in relation to a state in which at least one dispensing device is held on the holding device. 【0039】 The present invention relates to a holding device for holding multiple dispensing devices, particularly such as automatic syringes. 【0040】 Preferably, the holding device according to the present invention is intended for use in conjunction with a dispensing device embodied for self-sufficient material dispensing. For this purpose, the dispensing device comprises and / or forms a structured unit configured and functionalized for self-sufficient material dispensing. The dispensing device is then embodied for material dispensing independently of the holding device according to the present invention, such that the use of the dispensing device for material dispensing is also possible separately from the holding device. 【0041】 The holding device according to the present invention represents an individual auxiliary device for application when using multiple dispensing devices. 【0042】 In particular, the above-mentioned or each dispensing device can be configured, embodied, and / or functionalized for a single injection of a therapeutically and / or diagnostically effective substance. 【0043】 The structural and functional design of the holding device according to the present invention is provided in such a manner that material dispensing can be performed through at least one dispensing device connected to and / or held by the holding device according to the present invention, particularly through a plurality of connected and / or held dispensing devices, and more particularly through all connected and / or held dispensing devices, without the need to spatially and / or functionally isolate the connections. Material dispensing is possible, that is, when each dispensing device is held on the holding device according to the present invention. 【0044】 It is not excluded that relative movement occurs during material dispensing between the components of a material dispensing device connected to the holding device according to the present invention, and / or relative movement of the components of a material dispensing device with respect to the holding device according to the present invention. 【0045】 During the dispensing of a substance to the patient, the substance dispensing device is then manually held through a multi-holder according to the present invention and positioned relative to the patient. 【0046】 The use of the holding device according to the present invention, embodied as a multi-holder, is associated with several advantages. 【0047】 In contrast to holding devices embodied as a single holder and / or for holding only one dispensing device, the holding device according to the present invention allows two or more substance dispensing devices, in particular multiple auto-injectors, to be held simultaneously in a simple manner by the user's hand and positioned relative to the patient. 【0048】 The appropriate external geometric shape and / or external form of the holding device according to the present invention ensures a high level of user comfort, especially for individuals with motor impairments, when handling multiple dispensing devices. This is particularly applicable to auto-injectors having elongated and slender housings, which are often held only by individuals with motor impairments, where relative positional accuracy with respect to the patient's body is limited during drug dispensing. 【0049】 By selecting appropriate materials and / or surface structures for the holding device according to the present invention, good tactile perception of the holding device can be achieved, particularly during material dispensing, which further increases user comfort and facilitates precise positioning of the held dispensing device relative to the patient. 【0050】 The appearance of known material dispensing devices is generally determined primarily from a functional standpoint, which limits the design freedom when designing the appearance of material dispensing devices. In contrast, there is a high degree of design freedom when determining the appearance of the holding device according to the present invention, so that individual design requirements can be satisfied in a simple manner. 【0051】 Preferably, each substance dispensing device has an assembly for needle-assisted or needle-free substance dispensing to a patient, integrated and / or enclosed / enclosed in the outer housing of the substance dispensing device. The housing can be a functional component of the assembly, i.e., it can mechanically interact with other components of the assembly during substance dispensing, or it can simply contribute to enclosing / wrapping the assembly. Through the housing of the dispensing device, the dispensing device can be handled and / or held manually and positioned relative to the patient's body, while the dispensing device is not connected to and / or held on a holding device according to the present invention. The dispensing device is designed to function independently. 【0052】 By holding multiple dispensing devices on a holding device, multiple material releases can be achieved compared to material release using only one dispensing device. 【0053】 Preferably, and in particular, the holding device according to the present invention can be used to hold commercially available dispensing devices that have already undergone approval procedures under medical law. 【0054】 A second aspect of the present invention relates to an apparatus having the above-described holding device and at least one dispensing device for dispensing at least one therapeutically and / or diagnostically effective substance, in particular an auto-injector, in particular two or three or more dispensing devices, wherein the above or each dispensing device is a structured unit configured and functionalized for self-sufficient substance dispensing, and / or in particular the above or each dispensing device is configured and functionalized for single injection. 【0055】 In this regard, a third aspect of the present invention also relates to the use of the above-described type of holding device for holding at least one dispensing device for dispensing at least one therapeutically and / or diagnostically effective substance, in particular the holding of at least one auto-injector, and more particularly the holding of two or more dispensing devices, in particular the above or each dispensing device being a structured unit configured and functionalized for self-sufficient substance dispensing, and / or in particular the dispensing device being configured and functionalized for single injection. 【0056】 A fourth aspect of the present invention relates to the use of a holding device embodied as a multiple holder for simultaneous, particularly synchronous, dispensing of two or more dispensing devices held on a multiple holder, and more particularly for simultaneous dispensing of substances through two or more auto-injectors. 【0057】 A fifth aspect of the present invention relates to a method for multiple applications of therapeutically and / or diagnostically effective substances by dispensing substances through two or more dispensing devices, particularly through two or more autoinjectors, wherein each dispensing device forms and / or comprises a structured unit configured and functionalized for self-sufficient dispensing of substances, and / or each dispensing device is configured and functionalized for single injection. In the method according to the present invention, the dispensing devices are connected to a multiple holder, particularly a multiple holder of the type described above, before multiple applications, and are then held on the multiple holder in a connected state. The dispensing of substances is then performed through the dispensing devices, particularly simultaneously and more particularly synchronously. 【0058】 For simultaneous, and especially synchronous, material dispensing using the holding device according to the present invention, when multiple dispensing devices are held on a multi-holder according to the present invention, the holding device is preferably embodied for simultaneous material dispensing through dispensing devices on the same application plane of the dispensing devices. Material dispensing is then performed on the same application plane of the dispensing devices. This requires a certain arrangement of dispensing devices relative to each other, which is predetermined by the configuration and / or design of the holding device. 【0059】 Each substance dispensing device may be equipped with an actuator, for example, at its distal end facing the patient, which activates the trigger mechanism of the dispensing device and the dispensing of substance when the actuator is pressed against the patient's dosage dispensing site and / or skin. The holding device / multi-holder according to the present invention can then be embodied in such a way that the actuators of multiple, in particular, all substance dispensing devices connected to the holding device according to the present invention are preferably always located in the same application plane when the actuators are pressed against at least the dosage dispensing site. The term “application plane” may mean, for example, the proximal outer surface of the end face of an actuator that is located in a common skin contact plane that simultaneously contacts the patient's skin and simultaneously triggers the trigger mechanisms of multiple dispensing devices when moved in the direction of the dosage dispensing site for activation of substance dispensing by triggering a trigger mechanism of the type described in EP 2 745 866 A1 in the case of an auto-injector. 【0060】 The holding device according to the present invention can be embodied, in particular, to simultaneously hold multiple dispensing devices having the same design / shape and / or the same substance release volume. However, the preferred simultaneous holding of dispensing devices having different release volumes and / or containing different therapeutically and / or diagnostically effective substances is also not excluded. 【0061】 To facilitate handling of the holding device according to the present invention, to ensure an aesthetically pleasing and pleasant appearance, and to ensure secure attachment of dispensing devices to the holding device, the holding device may have a holder housing embodied to hold multiple dispensing devices, in particular to at least partially enclose / wrap them, and further to enclose / wrap at least a major or majority portion of the held dispensing devices. The terms “major portion” or “major portion” mean the larger proportion of the volume and / or surface area of ​​the dispensing devices enclosed in the holding device. 【0062】 Particularly preferably, the retaining device may have a holder housing formed by and / or comprising a plurality of shell components, particularly two semi-shell components, connected indirectly or directly to one another, particularly through fastening and / or latching connections, and furthermore, at least one gripping shell component having a U-shaped cross-section and a curved inner surface adapted to the shape of the connected semi-shell components in order to bring about a releasable or non-releasable fastening engagement with the connected semi-shell components. 【0063】 The holder housing and / or interacting shell components can form a multi-chamber system, such as a double chamber, for receiving / accepting multiple material dispensing devices, in particular multiple automatic syringes, and holding them in fixed positions on the holding device according to the present invention for material dispensing. 【0064】 Further aspects, features, characteristics, and advantages of the present invention will be described in detail below with reference to the diagrams, but the present invention is not limited to the aspects, features, characteristics, and advantages shown in the diagrams and described below. [Brief explanation of the drawing] 【0065】 [Figure 1] This is an exploded assembly diagram of the components of the holder housing of the holding device according to the present invention, in the state before assembly of the holder housing. [Figure 2] This is a top view of the holder housing in its assembled state (Figure 1). [Figure 3] This is a side view of the holder housing in the assembled state shown in Figure 1. [Figure 4] Figure 1 is a perspective view of the holder housing in its assembled state. [Figure 5] Figure 1 is a perspective view of an apparatus according to the present invention, comprising a holder housing and a retaining device having a withdrawal cap that is held in the retaining device for a therapeutically and / or diagnostically effective substance and connected to two dispensing devices. [Figure 6] Figure 5 is a top view of the apparatus. [Figure 7] Figure 5 is a side view of the apparatus. [Figure 8] Figure 5 is a perspective view of the device after the extraction cap has been extracted from the dispensing device. [Figure 9] This is a perspective view of another embodiment of the apparatus according to the present invention, which comprises a retaining device according to the present invention having a holder housing in an unassembled state and a withdrawal cap for connecting to two dispensing devices for therapeutically and / or diagnostically effective substances held in the retaining device. [Figure 10] Figure 9 is a perspective view of the device in its assembled state, including the holder housing. [Figure 11] Figure 10 is a side view of the holder housing. [Figure 12] This is an enlarged view of the distal front end of the holder housing shown in Figure 11. [Figure 13] This is an enlarged view of the proximal rear end of the holder housing shown in Figure 11. [Modes for carrying out the invention] 【0066】 Figures 1 to 4 illustrate the holding device 1, which is embodied as a dispensing device 2, for example, an automatic syringe, and more specifically, as a multiple holder for an automatic syringe of the type described in EP 2 742 962 A2. 【0067】 It is understood that all features, embodiments, characteristics, and advantages described below are not limited to this embodiment of the holding device 1 shown in the figures and the apparatus of the holding device 1 having two dispensing devices 2. This relates to the configuration and / or design of the holding device 1 and / or dispensing devices 2. 【0068】 The dispensing device 2 is embodied and functionalized for dispensing at least one therapeutically and / or diagnostically effective substance. During substance dispensing by the dispensing device 2, the holding device 1 is held by hand / manually and moved and / or guided to the dispensing site, in particular the injection site on the patient. 【0069】 Each dispensing device 2 is preferably embodied and functionalized for self-sufficient and / or autonomous material dispensing that is independent of the holding device 1, and comprises or forms a structured unit configured for this purpose. Each dispensing device 2 can then be used autonomously and independently of the holding device 1 for material dispensing. 【0070】 In the sense of the present invention, the term "self-sufficient material dispensing" means the state prior to the connection of the dispensing device 2 to the holding device 1 and / or the holding of the dispensing device 2 on the holding device 1. In particular, the dispensing device 2 is embodied and configured autonomously and independently of the holding device 1 for functionally independent material dispensing, which relates to the configuration of the dispensing device 2, in particular the trigger mechanism of the dispensing device 2 for triggering material dispensing. In other words, according to the present invention, the dispensing device 2 can be used and deployed to dispense material independently of the holding device 1, in particular. 【0071】 For the purposes described above, the dispensing device 2 may have a housing 5 that integrates an assembly for needle-assisted or needle-free material dispensing to a patient. This assembly may be enclosed within the housing 5. The housing 5 may be a functional part of the assembly, i.e., it may mechanically and / or functionally interact with other parts of the assembly during material dispensing, or it may simply serve to enclose the assembly. 【0072】 It is understood that the holding device 1 can be functionally configured as a multi-holder for a dispensing device, which differs in configuration and / or function from the configuration design partially shown in Figure 8, and also differs from the dispensing device design described in detail in EP 2 742 962 A2. 【0073】 In the illustrated embodiment, each of the dispensing devices 2 has an actuator 3 (Figure 8) at its distal front end as part of a trigger mechanism for automatic material dispensing. 【0074】 The holding device 1 is embodied as a multiple holder for holding a plurality of dispensing devices 2 and for dispensing material by at least one dispensing device 2 held on the holding device 1 while the plurality of dispensing devices 2 are held on the holding device 1. In the illustrated embodiment, the holding device 1 is embodied for holding two dispensing devices 2 and for dispensing material by both dispensing devices 2 held on the holding device 1. 【0075】 The dispensing devices 2 are fixed and / or stationary on the holding device 1 in a holding state such that dispensing of material by at least one dispensing device 2 is possible, and simultaneous dispensing of material by both dispensing devices 2 is possible in the illustrated embodiment. When multiple dispensing devices 2 are held on the holding device 1, the configuration of the holding device 1 allows dispensing of material by at least one dispensing device 2, and preferably by both dispensing devices 2 in the illustrated embodiment with multiple dispensing devices 2, without the need to separate these dispensing devices 2 from the holding device 1. The holding device 1 then serves as an assistive device for application during dispensing of material to the patient by the dispensing devices 2. 【0076】 Due to the possibility of holding multiple dispensing devices 2, for example, two automatic syringes using the holding device 1 and / or connecting these dispensing devices 2 to the holding device 1, the holding device 1 can be used in a manner advantageous to dispensing substances by multiple dispensing devices 2, and the dispensing devices 2 are held in a holding state on the holding device 1 before, during, and / or after dispensing substances, and can be positioned in particular relative to the patient and / or injection site. 【0077】 The holding device 1 allows for an increase in the dispensing volume when using multiple dispensing devices 2. 【0078】 The shape of the holding device 1 ensures a high level of user comfort, especially for people with motor impairments. 【0079】 By appropriately selecting the materials and / or surface design of the holding device 1, which is embodied as a multi-holder, good tactile perception of the holding device 1 can be achieved, thereby further enhancing user comfort and facilitating precise positioning on the patient. 【0080】 Furthermore, it is possible to design, configure, and determine the appearance of the retaining device 1 in a way that satisfies the high requirements for the design of the retaining device 1. 【0081】 In particular, each dispensing device 2 can be configured for a single injection of a therapeutically and / or diagnostically effective substance. 【0082】 In the illustrated embodiment, the holding device 1 is embodied in simultaneous material dispensing by the dispensing device 2 held thereon, and this material dispensing is performed synchronously, i.e., simultaneously and at the same speed, in the illustrated embodiment. 【0083】 Preferably, the design / configuration of the holding device 1 that holds multiple dispensing devices 2 allows for simultaneous dispensing of material by the dispensing devices 2 on the same application plane 4. This is schematically illustrated in Figure 8. 【0084】 In the illustrated embodiment, each dispensing device 2 has an elongated housing 5 with an actuator 3 at its distal front end. The actuator 3 can be a needle-protection sleeve that is displaceable relative to the housing 5 along the longitudinal axis of the housing 5 by a proximal operating stroke to an operating position for triggering material release / dispensing. 【0085】 In the initial position shown in Figure 8, before the trigger mechanism is triggered, the distal end of actuator 3 and / or needle protection sleeve protrudes distally over the needle tip of the dispensing device 2 so as to prevent access to the needle tip in the initial state. By moving actuator 3 with a proximal working stroke, actuator 3 is moved until the needle protrudes with a protrusion width that corresponds to the injection depth of the needle into the patient's puncture site from the distal end of each actuator 3. Substance release / substance dispensing is triggered when the distal end face 6 of actuator 3 is pressed against the dose delivery site. 【0086】 In the illustrated embodiment, the distal end face 6 of the dispensing device 2 is located on the same application plane 4. This ensures that when the dispensing device 2 is held by the holding device 1 and the distal end faces 6 of both actuators 3 are in contact with the patient's skin, these actuators 3 are simultaneously displaced proximal, and when the holding device 1 is further moved distally and / or toward the patient, both actuators 3 are further moved proximal, triggering material release / dispensing by a trigger mechanism located inside each dispensing device 2. 【0087】 During material dispensing, the dispensing device 2 is preferably held stationary on the holding device 1. That is, there is no relative movement between the housing 5 of the dispensing device 2 and the holding device 1 during material dispensing. However, relative movement of the actuator 3 relative to the holding device 1 is possible in order to trigger material release as described above. 【0088】 In the illustrated embodiment, the holding device 1 is embodied to hold a plurality of dispensing devices 2 having the same design / configuration and / or the same release volume. As a result, in the illustrated embodiment, the holding device 1 is embodied to hold two dispensing devices 2 that are identically embodied and functionally configured for substance dispensing. The dispensing devices 2 can contain the same or different substances that are therapeutically and / or diagnostically effective. 【0089】 However, in principle, the holding device 1 can be embodied in such a way that it holds dispensing devices 2 for dispensing various different substances, for example, by storing different volumes of therapeutically and / or diagnostically effective substances, and / or different geometric shapes and / or external shapes, and / or different therapeutically and / or diagnostically effective substances. 【0090】 The retaining device 1 is preferably a multi-piece configuration and / or comprises several parts / components. 【0091】 As can be seen particularly in Figure 1, the holding device 1 has a holder housing 7 embodied for holding a plurality of dispensing devices 2, and specifically for at least partially enclosing them as shown in Figure 1. In particular, the holder housing 7 is embodied in such a way as to receive and enclose at least the main or majority portion of each dispensing device 2 held inside it. The holder housing 7 is designed for or suitable for manual gripping of the holding device 1. 【0092】 The terms “main part” or “major part” mean a larger volume ratio and / or surface area ratio of the dispensing devices 2 housed in the holding device 1. In the sense of the present invention, “main part” or “major part” shall be understood, in particular, to mean a larger surface area ratio and / or a larger volume ratio of the housing 5 of each dispensing device 2 and / or each dispensing device 2. 【0093】 In the illustrated embodiment, the majority of each dispensing device 2 is essentially housed within the holder housing 7, and thus the holder housing 7 determines the appearance of the holding device 1, with only a very small portion of the dispensing device 2 contributing to the appearance of the holding device 1. Each dispensing device 2 may have an outer housing 5, and the holder housing 7 may be embodied in such a way as to accept at least a portion of the outer housing 5, or more specifically, a major / large portion of the outer housing 5. 【0094】 The holder housing 7 may have a passage 8, and while holding a plurality of dispensing devices 2 on the holding device 1, the actuator 3 and a portion of the housing 5 of the dispensing devices 2 are guided outward through the passage 8, protruding relative to the holder housing 7 and thus recognizable from the outside. 【0095】 In addition, if applicable, the dispensing device 2 can be completely enclosed within the holder housing 7, except for the actuator 3 and the small surface area of ​​the housing 5 of the dispensing device 2, as described above. 【0096】 Preferably, each dispensing device 2 has its own actuator 3 for triggering a substance release / substance dispensing and / or for triggering a mechanism that provides substance dispensing. 【0097】 A connecting element can be provided, which connects multiple actuators 3 to each other in order to cause simultaneous material dispensing by multiple dispensing devices 2 by activating it and thereby triggering the actuators 3. 【0098】 The holder housing 7 may include and / or be formed with chambers 11, 12 for receiving / accepting a plurality of dispensing devices 2 that are at least partially spatially separated and / or isolated. In particular, a double chamber may be provided for receiving / accepting two spatially separated automatic syringes, having a particularly elongated housing 5 for receiving / accepting two dispensing devices 2 that are at least partially spatially separated. Preferably, the chambers 11 and 12 can be separated from each other by the inner wall portion of the holder housing 7, at least section by section. 【0099】 Chambers 11 and 12 can have the same chamber volume and / or the same design / shape, which is advantageous when using dispensing devices 2 of the same design / shape and / or when using dispensing devices 2 having housings 5 ​​of the same design / shape. 【0100】 Fixing elements for securing the dispensing device 2 to the holding device 1 can be provided on the holding device 1 and / or on the holder housing 7. 【0101】 The holder housing 7 or the housing 5 of the dispensing device 2 may have fixing elements for forming a shape-fitting connection and / or a pressure-fit connection, in particular, for forming a mechanical connection between the respective dispensing device 2 and the holding device 1. 【0102】 The fixing elements can be provided on the holder housing 7 to prevent linear movement of the dispensing device 2 in the longitudinal and / or transverse directions relative to the holder housing 7, and / or rotational movement of the dispensing device 2 relative to the holder housing 7, when the dispensing device 2 is fixed and / or held on the holding device 1. These elements can be formed, for example, by the wall portion of the holder housing 7, and in particular by ribs or protrusions on the inner surface of the holder housing 7. 【0103】 Corresponding fixing elements can be provided on the holding device 1 and on each of the dispensing devices 2 to form a mechanical connection while the dispensing device 2 is held, and to secure the dispensing device 2 to the holding device 1 and / or within the holding device 1. 【0104】 The dispensing device 2 can be connected to the holding device 1 using material bonding, for example, by welding or gluing. 【0105】 In the illustrated embodiment, the holder housing 7 is formed by a shell assembly having a plurality of shell parts connected to each other. In particular, the shell assembly may have semi-shell parts 9, 10 connected to each other in the housing center plane Y (Figure 3) when the holding device 1 is assembled. 【0106】 In the assembled state when the half-shell components 9 and 10 are connected to each other (Figures 2 to 4), chambers 11 and 12 can be formed between the half-shell components 9 and 10 to receive / receive at least most of the portion of the dispensing device 2, and these chambers can be partially or completely separated from each other. The chambers 11 and 12 can be basically cylindrical and / or conical in the assembled state of the holding device 1 when the half-shell components 9 and 10 are stacked on top of each other and connected to each other. 【0107】 Furthermore, in the assembled state of the holding device 1, a plurality of ribs 13 having the same or different thicknesses can be formed / provided within the region of the central longitudinal axis X (Figure 2) of the semi-shell parts 9 and 10 to separate the chambers 11 and 12 from each other at least partially, preferably basically completely, so that the dispensing device 2 is held individually and preferably individually in a fixed position inside the holding device 1 and / or between the semi-shell parts 9 and 10. 【0108】 The wall portion of the semi-shell component 9 and the wall portion of the semi-shell component 10 enter into a functional, mechanical interaction state when the holding device 1 is assembled, thereby forming a shape-fitting connection and / or pressure-fit connection between the semi-shell components 9 and 10. For this purpose, the wall portion of the semi-shell component 9 and the wall portion of the semi-shell component 10 can be embodied / formed in a manner that is complementary to each other. 【0109】 To connect the semi-shell components 9 and 10 to each other, a fixing element that can interact with a complementary fixing element on the housing 5 of each dispensing device 2 can be provided and / or formed on at least one of the semi-shell components 9 and 10, preferably both semi-shell components 9 and 10. 【0110】 Each semi-shell component 9, 10 has a plurality of particularly two separate entry openings 14 for the dispensing device 2, and each semi-shell component 9, 10 can be embodied in such a manner that at least the main portion of the dispensing device 2 inserted through its respective entry opening 14 is received within the semi-shell component 9, 10. 【0111】 In the assembled state of the holding device 1, the half-shell parts 9 and 10 can be connected to each other with the entry openings 14 facing each other. Next, at least a portion of the dispensing device 2, preferably the main portion, is positioned between the half-shell parts 9 and 10, held by the holding device 1. With the half-shell parts 9 and 10 stacked on top of each other, they form a plurality of chambers 11 and 12 for preferably spatially separated receiving of a plurality of dispensing devices 2, as discussed above, and the entry openings 14 are closed by the half-shell parts 9 and 10 stacked on top of each other. 【0112】 Preferably, each of the half-shell components 9 and 10 may have semicircular opening geometric shapes 15 and 16 at its distal end relative to the dispensing device 2, and the complementary opening geometric shapes 15 and 16 can form a passage 8 for the outward guiding region of the dispensing device 2 when the holding device 1 is assembled. 【0113】 In the illustrated embodiment, the holder housing 7 is formed by and / or comprises two semi-shell components 9, 10 connected to each other indirectly or directly, particularly through fastening and / or latching connections. In the illustrated embodiment, there are further provided two gripping shell components 17, 18, which may have a U-shaped cross-section. The gripping shell components 17, 18 may have curved inner surfaces adapted to the shape of the connected semi-shell components 9, 10 in particular to provide a releasable or non-releasable fastening engagement with the connected semi-shell components 9, 10. 【0114】 The gripping shell components 17 and 18 hold the semi-shell components 9 and 10 in the assembled state of the holding device 1 in a shape-matching manner and / or pressure-fitting manner, particularly in a latching manner and / or fastening manner, preferably by embracing / surrounding the semi-shell components 9 and 10 from both sides, at least in some area / partially from the outside. This can be seen from a comparison between Figure 1 and Figures 2 through 4. 【0115】 As can be seen in Figures 2 to 4, the gripping shell components 17 and 18, in the assembled state of the holding device 1, interlock the semi-shell components 9 and 10 from the outside with their opposing longitudinal sides 19 and 20, and hold them together by latching and / or fastening, particularly in a shape-adjusting manner and / or pressure-fitting manner. 【0116】 To form a secure connection between the semi-shell components 9 and 10 through the gripping shell components 17 and 18, complementary openings 21 and projections 22 (Figure 1) can be provided on the semi-shell components 9 and 10 and / or on the gripping shell components 17 and 18 (on the other side) so that when the gripping shell components 17 and 18 are pressed transversely onto the already connected semi-shell components 9 and 10 enclosing the dispensing device 2, the gripping shell components 17 and 18 form a tightening connection / shape-adjusting connection, particularly a latch connection, with the semi-shell components 9 and 10. 【0117】 The gripping shell components 17 and 18 can be connected to the semi-shell components 9 and 10 in such a way that they cannot be separated without breaking them, or they can be separated without breaking them. 【0118】 To achieve a visually pleasing and pleasing appearance for the apparatus shown in Figures 5 to 8, formed by the holding device 1 with the two dispensing devices 2 received within the holding device 1, the shapes of the gripping shell parts 17 and 18 can be adapted to the shapes of the semi-shell parts 9 and 10, which are stacked on top of each other in the assembled state of the holding device 1. 【0119】 Projections in the form of beads 23, 24 can be provided on the outer surfaces of the semi-shell components 9, 10 to extend transversely across two connected semi-shell components 9, 10 in at least a portion of the area, and to form a seat to which each gripping shell component 17, 18 can be attached / fixed. Referring to Figure 4, a substantially flush transition can be formed in the seat edge region between the outer surfaces 25 of the gripping shell components 17, 18 and the outer surfaces 26, 27 of the adjacent semi-shell components 9, 10. 【0120】 Furthermore, as provided in the illustrated embodiment, the gripping shell components 17, 18 may have an outer profile in the form of ribs 28 and / or rubber covering to achieve improved tactile perception during handling of the holding device 1 and a high level of user comfort, particularly when holding the holding device 1 during material dispensing. 【0121】 The gripping shell components 17 and 18 can be positioned adjacent to the proximal end of the holding device 1, and can further extend from the central region of the holding device 1 toward the proximal end of the holding device 1. The gripping shell components 17 and 18 can extend proximal to the edge strips 29 of the half-shell components 9 and 10, and thus can be spaced away from the proximal end of the holding device 1. The edge strips 29 can have a width of, for example, 0.5 cm to 2 cm. 【0122】 The proximal end is formed by a housing cover 31 having a circumferential projection 32. 【0123】 In the assembled state of the holding device 1, the housing cover 31 is attached to the outer edge 30 of the axial end of the holder housing 7. 【0124】 Preferably, the housing cover 31 can be fastened to the holder housing 7, particularly to the semi-shell parts 9 and 10 which are stacked vertically on top of each other and connected in an assembled state, by a shape-adjusting method and / or a pressure-fitting method, or sometimes by a material-fitting method by (adhesive) bonding or welding, and the protrusion 32 can engage with a recess formed between the semi-shell parts 9 and 10 to form a fastening connection. 【0125】 In particular, as can be seen in Figures 2 and 3, the holder housing 7 may have an outer profile shape having a profile narrowing portion / profile constriction portion 33, 34 and a central profile widening portion 36. The profile constriction portions 33, 34 are formed by the concave surface of the holder housing 7. The profile constriction portions 33, 34 may be formed to extend around the circumferential direction and / or may extend across the wide, flat sides or upper and bottom sides of the holder housing 7 (Figure 3) and the narrow, flat sides or left and right outer sides (Figure 2). 【0126】 Accordingly, within the area of ​​the gripping shell components 17, 18, the holder housing 7 preferably has a substantially concave shape, and / or the surfaces of the gripping shell components 17, 18 are substantially curved inward. 【0127】 A first profile narrowing portion / first profile constriction portion 33 can be formed / provided adjacent to the distal end of the holder housing 7. 【0128】 A second profile narrowing portion / second profile constriction portion 34 can be formed / provided adjacent to the proximal end of the holder housing 7. 【0129】 The first profile constriction 33 can extend between the edge strip 35 at the distal end of the holder housing 7 and the central region of the holder housing 7, particularly the central profile widening portion 36. The edge strip 35 can have an axially parallel outer surface, particularly parallel to the central longitudinal axis X. Each of the edge strip 35 and the central region can define a widening portion of the housing profile. 【0130】 The second profile narrowing portion 34 may extend proximal from the central region, particularly the central profile widening portion 36, to the edge strip 29 of the holder housing 7, the edge strip 29 may have an axially parallel outer surface, particularly parallel to the central longitudinal axis X. The edge strip 29 further forms another profile widening portion. 【0131】 The terms “profile constriction” and “profile widening” refer specifically to the profile of the holder housing 7 as seen from above (Figure 2) and / or from a cross-sectional view (Figure 3) of the retaining device 1. Due to a central profile widening section 36, another profile widening section at the end of the holder housing 7, and profile constrictions 33, 34 between them, the holder housing 7 may have a wavy profile. This wavy profile can be seen in Figures 2 and 3, where dashed lines 37, 38 reveal the profile of the holder housing 7. The dashed lines 37, 38 are lines drawn tangentially to the proximal edge portion / edge strip 29 and the distal edge portion / edge strip 35 of the holder housing 7. 【0132】 As is further evident from these figures, the half-shell components 9 and 10 may have observation windows 39 adjacent to the distal end of the holding device 1, and the observation windows 39 may be positioned opposite the observation window 58 of the dispensing device 2 (see Figure 9) when the holding device 1 is assembled. Preferably, an opposing observation window 39 is provided for each dispensing device 2. 【0133】 Through the observation window 39, for example, when using two automatic syringes, it is possible to visually observe the dispensing of material after triggering the automatic dispensing process. 【0134】 Each dispensing device 2 may include, for example, a product container in the shape of a syringe that is immovably received along the longitudinal axis of the dispensing device 2. The product container may have a sleeve-shaped syringe body / syringe barrel, the syringe body surrounding a plunger or piston that fits tightly to its inner circumference. The syringe body may have a needle at its distal end, and a liquid substance, such as a drug / medicine, can be placed between this needle and the plunger or piston within the syringe body. The substance can be dispensed / released from the product container through the needle by moving the plunger or piston toward the needle in the distal dispensing / release direction. After a trigger mechanism for driving the plunger or piston is triggered, the displacement movement of the plunger or piston in the distal release / dispensing direction, and thus the progression of the release process, can be visually inspected through the observation window 39. 【0135】 As can be seen particularly in Figure 4, the holder housing 7 may have a circumferential contour at its distal end that is adapted to the cylindrical housing shape of the dispensing device 2 and / or the circular passage 8 of the holder housing 7. In the end view of the holding device 1, this contour may have an outer convex contour portion 46 that is positioned adjacent to both longitudinal portions 19, 20 (Figure 2) on either side of the central longitudinal axis X and connected to each other by a central concave contour portion 47 within the region of the central longitudinal axis X. 【0136】 In the initial or delivery state of the apparatus formed by the holding device 1 and a plurality of dispensing devices 2, a withdrawal cap 40 may be provided at the distal front end of the apparatus, which is removed by pulling it out or sometimes twisting it off before the dispensing devices 2 are used. A withdrawal cap for withdrawing a needle protection cap is described, for example, in EP 2 745 866 A1. This known withdrawal cap has been embodied and functionalized for use with a single dispensing device. 【0137】 As shown in Figure 8, the housing 5 of the dispensing device 2 can pass through the passage 8 of the holding device 1 at its distal end such that, when the dispensing device 2 is held, the edge strips 41 of each housing 5 protrude distally relative to the distal end face 42 (Figure 4) of the holding device 1. The pull-out cap 40 can be connected to the dispensing device 2 within the area of ​​the edge strips 41 of the housing 5, and in particular can be inserted across the edge strips 41. 【0138】 Similarly, the actuator 3 of the dispensing device 2 also extends through the passage 8 and protrudes distally relative to the distal end face 42 of the holder housing 7. The extraction cap 40 can form two separate receiving regions 48, 49 for the actuator 3 (Figure 6). The extraction cap 40 may have reinforcing ribs on its inner wall. 【0139】 As described above, the actuator 3 can be a needle protection sleeve that is displaceable along the longitudinal axis of the housing 5 of each dispensing device 2 relative to the housing 5 by a proximal working stroke to an operating position for triggering substance release / dispensing. Thus, in the initial position and / or dispensing state, the distal end of the needle protection sleeve protrudes distally over the needle tip of the syringe barrel / syringe body housed in the housing 5 of each dispensing device 2. This prevents access to the needle tip in the initial state. By displacing the needle protection sleeve with a proximal working stroke, the needle protection sleeve is displaced until the needle protrudes from the distal end of the needle protection sleeve with a protrusion width corresponding to the injection depth of the needle into the patient's puncture site. In this regard, the trigger mechanism of the dispensing device 2 can correspond to the trigger mechanism of an auto-injector known from EP 2 742 962 A2. 【0140】 In its initial or shipping state, the pull-out cap 40 can be pushed, slid, and / or inserted across the edge portion / edge strip 41 with the wall portion 43 extending in the axial direction. 【0141】 As shown in Figure 8, the contour of the pull-out cap 40 at the proximal edge of the wall portion 43 can follow the contours of the two edge strips 41 of the housing 5 of the dispensing device 2 in the circumferential direction of the pull-out cap 40. 【0142】 The two dispensing devices 2 are arranged so as to be adjacent to each other in the transverse direction with respect to the central longitudinal axis X. 【0143】 In the initial or dispensing state of the holding device 1 when the dispensing device 2 is held on the holding device 1, each needle of the dispensing device 2 can be covered with a needle protection cap or a hard needle shield / soft needle shield to protect the needle from contamination and keep the contents inside the syringe body sterile. The needle protection cap can be placed on the needle holding portion of the syringe body. 【0144】 In the initial or delivery state, the withdrawal cap 40 can be connected to the dispensing device 2 and / or the holder housing 7, in particular, by a shape-fitting / tightening and / or pressure-fitting / loosening method, for example, through a snap fastening connection. In the illustrated embodiment, the withdrawal cap 40 can be detachably connected to the dispensing device 2 or to the needle protection sleeve of the dispensing device 2, which forms the actuator 3 for triggering material dispensing, within the area of ​​the edge strip 41 of the housing 5, and in particular, can be snap fastened. This snap fastening can be released when the withdrawal cap 40 is removed from the housing 5 and / or the needle protection sleeve. By connecting the withdrawal cap 40 to both dispensing devices 2 in the initial or delivery state of the retaining device 1, reliable retention / holding of the withdrawal cap 40 onto the retaining device 1 through the dispensing device 2 is ensured. However, in principle, it is conceivable that the withdrawal cap 40 can be directly connected to the holder housing 7 of the retaining device 1 in a shape-fitting and / or pressure-fitting detachable method. 【0145】 In the initial or delivery state, i.e., when the withdrawal cap 40 is connected to the dispensing device 2, the needles of each dispensing device 2 can be covered with a needle protection cap that can be embodied as a so-called rigid needle shield or a flexible needle shield, in order to protect the needles of each dispensing device 2 from contamination and to keep the contents inside the product container sterile. The needle protection cap can be placed on the needle holding portion of the syringe body / syringe barrel of each dispensing device 2. 【0146】 The withdrawal cap 40 may include two withdrawal members 44, each of which can be embodied as a catch that engages in the gap between the syringe body of the dispensing device 2, particularly its tapered region, and the proximal end of the needle protection cap of each dispensing device 2. When the withdrawal cap 40 is removed from the retaining device 1, the catches can hook into the gap, thereby releasing the needle protection cap of each dispensing device 2 from the syringe body and removing it from the dispensing device 2 together with the withdrawal cap 40. The withdrawal cap 40 allows for the simultaneous withdrawal and / or removal of the needle protection caps of the dispensing devices 2. 【0147】 In the initial or delivery state, the extraction member 44 engages proximal to the actuator 3, which is embodied as a needle protection sleeve. In the initial or delivery state, the extraction cap 40 receives / accepts the actuator 3 of the dispensing device 2 at least partially, preferably completely. When the extraction cap 40 is connected to the dispensing device 2, the actuator 3, which projects distally to the distal end face 42 of the holder housing 7 through the passage 8 of the holder housing 7, and more preferably the edge strip 41 of the housing 5 of the dispensing device 2, are also preferably completely surrounded / enclosed by the extraction cap 40. Preferably, the actuator 3, which projects distally through the passage 8 of the holder housing 7, and the edge strip 41 of the housing 5 of the dispensing device 2 are then completely surrounded and / or enclosed around the entire circumference in the circumferential direction of the extraction cap 40 by the edge portion / wall portion 43 of the extraction cap 40. 【0148】 The extrusion member 44 can be an integral part of the extrusion cap 40, may contain plastic material, and / or be molded onto the extrusion cap 40. For design reasons, the extrusion cap 40 may be transparent and / or be manufactured from transparent plastic material. The extrusion member 44 can be integrally molded onto the wall portion 45 of the extrusion cap 40 that forms the distal end of the extrusion cap 40. 【0149】 For example, each of the extraction members 44 may have one or more snap-fastening arms for forming a snap-fastening connection with the needle protection cap of each dispensing device 2. 【0150】 However, in principle, the extraction member 44 may also have an extraction sleeve made of, for example, metal, in which case each extraction sleeve may have at least one snap-fastening projection provided for extracting the needle protection cap of each dispensing device 2. The extraction sleeve can be connected to the extraction cap 40 by a shape-adjusting method and / or a pressure-fitting method. For example, a sleeve-shaped retaining portion can be molded and / or formed / provided inside the extraction cap 40, into which the extraction sleeve can be inserted and, where applicable, connected to the extraction cap 40 via a snap-fastening connection. 【0151】 In particular, the holding device 1 can be adapted and / or personalized to the use of a dispensing device 2 having a specific shape, i.e., a specific external geometric shape and / or specific dimensions. Personalization can be applied so that only certain dispensing devices 2 can be held on the holding device 1 according to the present invention. 【0152】 The holding device 1 according to the present invention can preferably be realized and / or embodied only for holding a dispensing device 2 having a specific dispensing volume of a particular substance and / or a particular type and / or composition of substance that is therapeutically and / or diagnostically effective. For this purpose, the holding device 1 according to the present invention may be provided with distinguishing means (not shown) for indicating that it can be used only to hold a certain dispensing device 2 and / or for ensuring that only a certain dispensing device 2 is used. 【0153】 The holding device 1 according to the present invention may be embodied, for example, only to hold a dispensing device 2 having a housing 5 of a certain size and / or shape, in particular having certain geometric features. The geometric features of the dispensing device 2 then represent a distinguishing means in the sense of the present invention. For example, the holding device 1 may have a receiving area such as chambers 11, 12 for the dispensing device 2 to be held. In this case, only a dispensing device 2 having a size and / or shape in particular for the outer housing 5 that corresponds to the size and / or shape of the receiving area can be connected to the holding device 1 according to the present invention. For example, the holding device 1 according to the present invention may be configured to hold two auto-injectors having different discharge volumes, in which case, for example, the first auto-injector may have a maximum discharge volume of 2.5 ml and the second auto-injector may have a maximum discharge volume of 5 ml. Furthermore, the holding device 1 may have two chambers of different sizes, in which case the first chamber may be formed to hold the first auto-injector and the second chamber may be formed to hold the second auto-injector having a larger discharge volume. 【0154】 Mechanically effective elements, such as protrusions and / or recesses, that interact with corresponding mechanical elements on the holding device 1 when the dispensing device 2 is inserted into the receiving area of ​​the holding device 1, for example, chambers 11, 12, or when it is inserted, can also be provided on the dispensing device 2. A dispensing device 2 without such corresponding effective elements cannot then be used with the holding device 1 according to the present invention. Thus, these mechanically effective elements also represent distinguishing means in the sense of the present invention. 【0155】 To ensure that the holding device 1 according to the present invention is used only to hold a certain dispensing device 2, certain areas of the holding device 1 and the specific dispensing device 2 may have the same color scheme as the distinguishing means, and / or the holding device 1 and the dispensing device 2 may have the same code, for example, in the form of a number or letter. Electronic codes are also possible. In this case, the color scheme and / or code can be used to ensure that the holding device 1 is used only with the intended dispensing device 2. 【0156】 When the holding device 1 according to the present invention is used in particular in simultaneous use with a plurality of different dispensing devices 2 that can contain different release volumes and / or different substances, the above-described type of distinguishing means can be provided to indicate to the user the intended position of each dispensing device 2 on and / or within the holding device 1. 【0157】 The illustrated holding device 1 is solely for holding the dispensing device 2, which is structurally and functionally identical, particularly with respect to the discharge volume and / or even more particularly with respect to the trigger mechanism. 【0158】 However, it is understood that the holding device 1 can be embodied in a way that holds multiple different dispensing devices. 【0159】 The holding device 1 is preferably embodied in holding the dispensing device 2 in a stationary state during material dispensing. Therefore, in particular, there is no relative movement of the housing 5 of the dispensing device 2 with respect to the holding device 1. However, as described above, the actuator 3 can perform relative movement to trigger the trigger mechanism of the dispensing device 2. 【0160】 Figures 9 to 13 illustrate yet another embodiment of the apparatus according to the present invention, comprising two dispensing devices 2, for example, an automatic syringe, and further a holding device 1 for an automatic syringe of the type described, for example, EP 2 742 962 A2. The apparatus shown in Figures 5 to 8 and the apparatus shown in Figures 9 to 13 use the same reference numerals to indicate the same components and the same structural and / or functional design / configuration. 【0161】 The above discussion / description regarding the structural and / or functional design / configuration of dispensing device 2 also applies to the apparatus shown in Figures 9 to 13. 【0162】 In the embodiments illustrated in Figures 9 to 13, the holding device 1 is again embodied in holding two dispensing devices 2, and further in dispensing material by both dispensing devices 2 held on the holding device 1. In the holding state, the dispensing devices 2 are positioned on the holding device 1 in a stationary and / or fixed state, and therefore, in the holding state, material dispensing is possible by at least one of the dispensing devices 2, and in the illustrated embodiments, both dispensing devices 2 simultaneously. This configuration of the holding device 1 enables material dispensing by both dispensing devices 2 without the need to separate these dispensing devices 2 from the holding device 1. The holding device 1 then contributes / functions as an application aid when dispensing material to the patient by the dispensing devices 2. 【0163】 In the illustrated embodiment, each dispensing device 2 also has an elongated housing 5, each having an actuator 3 at its distal front end. In this case, the actuator 3 is a needle protection sleeve that is displaceable in the proximal direction to trigger material release / dispensing, as described in EP 2 742 962 A2. Other embodiments / configurations of the actuator 3 are possible, e.g., actuators that are actuated and / or triggered from the side. The holder housing will therefore be adapted accordingly. 【0164】 The distal end face 6 of the dispensing device 2 is located on the same application plane 4, as shown in Figure 8. 【0165】 The dispensing device 2 is held stationary on the holding device 1 during material dispensing. As can be seen in Figure 9, the holding device 1 also has a holder housing 7 which is embodied in a manner that holds and encloses / wraps the main parts of the multiple dispensing devices 2. The definition of the term “main parts” corresponds to the definition disclosed above in relation to the first embodiment described with reference to Figures 1 to 8. 【0166】 The holder housing 7 has a passage through which the actuator 3 of the dispensing device 2 is guided outward while multiple dispensing devices 2 are held on the holding device 1, protruding relative to the holder housing 7 and thus recognizable from the outside. In contrast to the embodiments described in Figures 1 to 8, in the embodiments shown in Figures 9 to 13, it is preferable that only the actuator 3 protrudes axially relative to the half-shell parts 9 and 10 of the holder housing 7 when the device is held. Furthermore, when the dispensing device 2 is held, the axial end face 50 of the housing 5 of the dispensing device 2 is preferably flush distally with the axial end face 51 of the half-shell parts 9 and 10. However, the housing 5 of the dispensing device 2 can protrude relative to the holder housing 7 together with the axial edge strip and be guided axially outward through the passage so as to be recognizable from the outside, as described above. 【0167】 As described above, the holder housing 7 or the housing of the dispensing device 2 may have fixing elements to form a shape-fitting connection and / or a pressure-fit connection for forming a mechanical connection between each dispensing device 2 and the holding device 1. As shown in Figure 9, for example, fixing elements 52, 53 may be formed / provided on the inner surfaces of the semi-shell parts 9, 10, for example, by particularly rib-shaped wall portions on the inner surfaces of the semi-shell parts 9, 10, and preferably interact with the corresponding complementary geometric shapes and / or complementaryly formed surface portions on the outer surface of the housing 5 of the dispensing device 2. As a result, linear movement of the dispensing device 2 in the longitudinal and / or transverse directions relative to the holder housing 7, and / or rotational movement of the dispensing device 2 relative to the holding device 1 can be prevented when the dispensing device 2 is fixed and / or held on the holding device 1. Furthermore, complementary fixing elements can be provided on the holding device 1 and on each of the dispensing devices 2 to form a mechanical connection while the dispensing device 2 is being held, and to secure the dispensing device 2 to the holding device 1 and / or within the holding device 1. 【0168】 In the embodiment shown in Figure 9, the rib-shaped fixing elements 52 and 53 can be adapted to the circular contour of the housing 5 of the dispensing device 2. In particular, the fixing elements 52 and 53 of the housing 5 of the dispensing device 2, more preferably the corresponding fixing elements and / or wall portions acting as fixing elements, can enable a snap-fastening or latching connection between the housing 5 and the housing holder 7 when the dispensing device 2 is fixed and / or held on the holding device 1. 【0169】 To connect the half-shell components 9 and 10, latch projections 54 and 55 can be provided on the upper half-shell component 9, which engage in corresponding latch recesses 56 and 57 within the lower half-shell component 10 when the half-shell components 9 and 10 are connected to each other in the assembled state of the retaining device 1. The latch projections 54 and 55 can be elastically snapped into the latch recesses 56 and 57. 【0170】 Furthermore, the connection between the semi-shell parts 9 and 10 can be provided by a tongue and groove form fit method through the edges of the semi-shell parts 9 and 10. 【0171】 Here again, each half-shell component 9, 10 has a separate entry opening for the dispensing device 2, as described above with reference to the first embodiment in Figures 1 to 8. 【0172】 Furthermore, two gripping shell components 17 and 18 are provided, which can provide a releasable or non-releasable fastening engagement with the connected semi-shell components 9 and 10. The gripping shell components 17 and 18 hold the semi-shell components 9 and 10 to each other in a shape-matching and / or pressure-fitting manner when the holding device 1 is assembled, and can hold the semi-shell components 9 and 10 together from the outside in at least a certain area on both sides. In this regard, please also refer to the above description of the embodiment of the holding device 1 described with reference to Figures 1 to 8. The connection of the gripping shell components 17 and 18 to the semi-shell components 9 and 10 is, in this case, made by at least two protrusions 22 on each gripping shell component 17 and 18 and complementary openings 21 in the semi-shell components 9 and 10, respectively. 【0173】 Furthermore, in the initial state or delivery state of the device formed by the holding device 1 and the multiple dispensing devices 2, a withdrawal cap 40 can be provided at the distal end of the device. As shown in Figures 9 and 10, the withdrawal cap 40 can be held on the actuator 3 of the dispensing device 2, and in particular, can be inserted onto the actuator 3. 【0174】 In addition, the semi-shell components 9 and 10 may be provided with radially inwardly extending, preferably circumferentially radially rib-shaped retaining and / or reinforcing portions 59 on the inside of their proximal ends, which can provide axial fixation of the dispensing device 2 in the semi-shell components 9 and 10. 【0175】 Finally, at least one of the semi-shell components 9, 10 may have a label carrier 60 embodied in such a manner that it displays to the user information regarding the type, quantity, and / or composition of a therapeutically and / or diagnostically effective substance dispensed by the dispensing device 2. The label carrier 60 may be embodied as a separate element that can be attached to the semi-shell components 9, 10 in a shape-adjusting and / or pressure-fitting manner, particularly in a latching and / or fastening manner. However, in its simplest form, the label carrier 60 may also be a tag / sticker attached to the outer surface of the semi-shell components 9, 10. 【0176】 The configuration / design of the label carrier 60 as a separate label display element detachably connected to the semi-shell components 9 and 10 offers the advantage that the holding device 1 can be used in a simple manner for dispensing devices 2 with different types, quantities, and / or compositions of substances being dispensed, and various information for labeling different types, quantities, and / or compositions of substances can be added to the label carrier 60. 【0177】 The device formed by the holding device 1 and the multiple dispensing devices 2 can be in its initial or delivery state, i.e., pre-assembled when delivered by the factory to a user or professional such as a pharmacist. However, the holding device 1 and the multiple dispensing devices 2 can be in their unassembled state in the initial or delivery state, and / or delivered as individual components, for example, as a kit. The user or professional such as a pharmacist can assemble the device on-site and / or immediately before its use. 【0178】 The holding device 1 is preferably embodied for disposable and / or single use. As described above, the apparatus formed by the holding device 1 and the multiple dispensing devices 2 cannot be separated / disassembled in a non-destructive manner once assembled. Preferably, the holding device 1, in particular the half-shell parts 9, 10 of the holder housing 7, cannot be opened / separated in a non-destructive manner when connected to each other using the gripping shell parts 17, 18. 【0179】 However, in another embodiment, the holding device 1, particularly the half-shell components 9 and 10, can be separated / opened without destruction, for example by removing the gripping shell components 17 and 18 from the half-shell components 9 and 19. In this way, the holding device 1 can be reused. 【0180】 List of reference symbols 1. Holding device 2. Small-batch devices 3 Actuators 4 Applicable plane 5 Housing 6 End face 7 Holder Housing 8 aisles 9 Half-shell parts 10 Half-shell parts 11 Chambers 12 Chambers 13 Ribs 14 Entry opening 15 Aperture geometry 16 Aperture geometry 17 Gripping shell component 18 Gripping shell component 19 Long side 20 Long side 21 Opening 22 Protrusion 23 Beads 24 Bead 25 Exterior 26 Exterior 27 Exterior 28 Ribs 29 Edge strip 30 Outer edge 31 Housing Cover 32 Protrusion 33 Profile narrowing area 34 Profile narrowing area 35 Edge strip 36 Profile widening section 37 lines 38 lines 39 Observation window 40 Pull-out caps 41 Edge strip 42 End face 43 Wall section 44 Extraction Member 45 Wall section 46 Outline 47 Outline 48 Acceptance Areas 49 Acceptance Areas 50 End face 51 End face 52 fixed elements 53 Fixed elements 54 Latch projection 55 Latch projection 56 Latch recess 57 Latch recess 58 Observation window 59 Retention / reinforcement part 60 Label carriers X-center longitudinal axis Y Housing Center Plane

Claims

[Claim 1] A holding device (1) embodied as a multiple holder for holding two or more dispensing devices (2) on the holding device (1), and for dispensing a substance through at least one dispensing device (2) held on the holding device (1) in a state of holding the dispensing devices (2), a dispensing device (2) for dispensing at least one therapeutically and / or diagnostically effective substance, particularly for an autoinjector, The holding device (1) has a holder housing (7) for holding the dispensing device (2) and for at least partially enclosing the dispensing device (2), the holder housing (7) comprises two half-shell components (9, 10), A holding device (1) characterized by the following: [Claim 2] The holding device (1) according to claim 1, characterized in that it is embodied for simultaneous dispensing of materials through the dispensing device (2), particularly for synchronous dispensing of materials. [Claim 3] The holding device according to any one of claims 1 to 2, characterized in that it is embodied for dispensing a substance through the dispensing device (2) on the same application plane (4) of the dispensing device (2). [Claim 4] The holding device (1) according to any one of claims 1 to 3, characterized in that it is implemented to hold the dispensing device (2) in a stationary manner while dispensing a small amount of material. [Claim 5] A holding device (1) according to any one of claims 1 to 4, which is embodied to hold a dispensing device (2) of the same design and / or having the same discharge volume. [Claim 6] The retaining device (1) according to any one of claims 1 to 5, characterized in that the semi-shell components (9, 10) are indirectly or directly connected to each other through fastening connections and / or latching connections. [Claim 7] The holding device (1) according to any one of claims 1 to 6, characterized in that it is provided with at least one gripping shell component (17, 18) that holds the semi-shell components (9, 10) in a shape-matching manner and / or a pressure-fitting manner and / or that surrounds the semi-shell components (9, 10) from the outside on at least partially both sides. [Claim 8] The holding device (1) according to claim 7, characterized in that the gripping shell components (17, 18) have a U-shaped cross-section and, in particular, a curved inner surface adapted to the shape of the connected half-shell components (9, 10) to provide a releasable or non-releasable fastening engagement with the connected half-shell components (9, 10). [Claim 9] The holding device (1) according to claim 7 or 8, characterized in that the surfaces of the gripping shell components (17, 18) are curved at least substantially inward. [Claim 10] A holding device (1) according to any one of claims 7 to 9, characterized in that projections, particularly beads (23, 24), are provided on the outer surfaces of the half-shell components (9, 10) to form a seat that extends laterally at least partially on the two connected half-shell components (9, 10) and to which the gripping shell component (17, 18) can be attached, and in particular, preferably a substantially flush transition is provided between the outer surfaces (25, 26, 27) of the gripping shell component (9, 10) and the outer surfaces (25, 26, 27) of the half-shell components (9, 10). [Claim 11] The holder housing (7) is characterized by comprising a profile constriction portion (33, 34) adjacent to the distal end of the holder housing (7) and / or a profile constriction portion (33, 34) adjacent to the proximal end of the holder housing (7), as described in any one of claims 1 to 10. [Claim 12] The retaining device (1) according to any one of claims 1 to 11, further comprising at least one withdrawal cap (40) detachably connected to the holder housing (7) of the dispensing device (2) and / or the retaining device (1), and further embodied using means for simultaneously removing the needle protection cap of the dispensing device (2), and / or embodied to at least partially, preferably completely, receive a plurality of actuators (3) of the dispensing device (2). [Claim 13] It is a device, The holding device (1) is as described in any one of claims 1 to 12. At least one dispensing device (2) for dispensing at least one therapeutically and / or diagnostically effective substance, comprising an auto-injector, in particular The device comprises two or more dispensing devices (2), particularly The aforementioned dispensing device (2) comprises a structured unit configured for self-sufficient dispensing of material. Device. [Claim 14] A use of a holding device (1) according to any one of claims 1 to 13 for holding at least one dispensing device (2) for dispensing at least one therapeutically and / or diagnostically effective substance, particularly for holding two or more dispensing devices (2) for holding an autoinjector, Preferably, the dispensing device (2) comprises a structured unit configured for self-sufficient dispensing of material. use. [Claim 15] A method for multiple applications of therapeutically and / or diagnostically effective substances by dispensing the substance in small amounts through two or more dispensing devices (2), particularly through two or more auto-injectors, The dispensing device (2) is connected to the holding device (1), particularly the holding device (1) described in any one of the prior claims 1 to 12, before the multiple application, and is held on the holding device (1) in a connected state for multiple application, particularly The dispensing of the substance is performed simultaneously, and more particularly synchronously, through the dispensing device (2), and / or particularly The material dispensing is performed on the same application plane (4) of the dispensing device (2), and / or in particular Each dispensing device (2) has a structured unit configured for self-sufficient dispensing of material. method.

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