Muscarinic M4 receptor agonists and their uses

Abstract

This invention relates to CHRM4 receptor agonists and their uses. The present invention discloses compounds represented by formula (I), or their stereoisomers, deuterides, solvates, cocrystals or pharmaceutically acceptable salts, and pharmaceutical compositions thereof, as well as their uses in the manufacture of drugs for the treatment / prevention of CHRM4-mediated diseases, where each group in formula (I) is as defined in the specification. [C1] TIFF2026521193000480.tif19156

Description

[Technical Field]

[0001] This invention belongs to the field of pharmaceuticals and, more particularly, to small molecule compounds having CHRM4 receptor agonist activity, their stereoisomers, deuterides, solvates, cocrystals or pharmaceutically acceptable salts, and their uses in the manufacture of drugs for treating related diseases. [Background technology]

[0002] mAChRs are widely distributed in the human body and, depending on their location and receptor subtype, mediate many physiological functions in the cardiovascular, renal, gastrointestinal, pulmonary, central, and peripheral nervous systems. mAChRs are typically expressed in various parts of the brain, and their function is involved in a wide range of brain circuits, including the regulation of neuronal excitability, synaptic plasticity, and acetylcholine release. All five types of mAChRs are expressed in brain neurons and glial cells, but the relative abundance of their receptors differs by region. The muscarinic acetylcholine receptor M4 (also called muscarinic 4 or CHRM4) is a protein encoded by the CHRM4 gene in humans. The M4 receptor is primarily expressed in the brain. Key brain regions where M4 receptor expression occurs are the striatum, cortex, and hippocampus, with the highest expression occurring in the striatum (approximately 46%), where M4 is the major muscarinic subtype. M4 can also be sporadically expressed in the periphery (e.g., testes, skin, and colon). [Overview of the Initiative] [Means for solving the problem]

[0003] The present invention provides low molecular weight compounds having CHRM4 activity, stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts thereof, wherein the compounds have the structures of formulas (I), (I-1), (I-1a), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7), (I-8), (I-1b), and (II). [ka] [ka] This indicates that the ring formed by X1-X4 contains one or more double bonds. A is selected from a 3-20 membered heterocycloalkyl group or a 5-20 membered heteroaryl group, the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the heterocyclyl group and heteroaryl group optionally contain 0-5 R A Substituted with, in some embodiments, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, a 9-10 member bicyclic heteroaryl group, a 10-14 member tricyclic heterocycloalkyl group, and a 10-14 member tricyclic heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group are optionally 1-5 R A Substituted with, in some embodiments, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, a 10-14 member tricyclic heteroaryl group, and a 10-14 member tricyclic heterocycloalkyl group, wherein the heterocycloalkyl group and heteroaryl group optionally have 1-5 R A Substituted with, in some embodiments, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, or a 10-14 member tricyclic heterocycloalkyl group, and the heterocycloalkyl group or heteroaryl group is optionally 1-5 R A Substituted with, in some embodiments, A is selected from a 5-membered heteroaryl group, a 6-membered heteroaryl group, a 5-6 membered heteroaryl group condensed into a 5-6 membered heteroaryl group, a 5-6 membered heteroaryl group condensed into a 5-7 membered heterocycloalkyl group, a 5-6 membered heteroaryl group condensed into a 5-6 membered carbocyclyl group, a 10-14 membered tricyclic heteroaryl group, and a 10-14 membered tricyclic heterocycloalkyl group, wherein the heteroaryl group, heterocycloalkyl group, and carbocyclyl group are optionally 1-5 R A It is replaced by, and in some embodiments, A is optionally 1 to 5 R ASelected from one of the groups formed by the following structures replaced by

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Chemical formula

Chemical formula

Chemical formula

[0004] As one specific technical example of the present invention, the present invention provides a compound represented by formula (I), its stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, [ka] A is selected from a 3-20 membered heterocycloalkyl group or a 5-20 membered heteroaryl group, the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the heterocyclic group and heteroaryl group optionally contain 0-5 R A Replaced by, B is bond, C 3-10 Cycloalkyl groups, C 6-12 Selected from an aryl group, a 3-12 membered heterocycloalkyl group, or a 5-12 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, aryl group, heterocyclyl group, and heteroaryl group optionally contain 0-5 R B Replaced by, C is C 3-12 Cycloalkyl groups, C 6-10 Selected from an aryl group, a 3-14 membered heterocycloalkyl group, or a 5-14 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, heterocycloalkyl group, aryl group, and heteroaryl group optionally contain 0-5 R C It is replaced by, and in some embodiments, C is C 3-12 Cycloalkyl groups, C 6-10Selected from an aryl group, a 3-12 membered heterocycloalkyl group, or a 5-12 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, heterocycloalkyl group, aryl group, and heteroaryl group optionally contain 0-5 R C Replaced by, L1 and L2 are independent of each other, W1-R L - Selected from W2, the left side of L1 is connected to A, and the left side of L2 is connected to B, R L is a bond, C 1-4 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, C 3-6 Selected from cycloalkyl groups, 5-12 membered heteroaryl groups, and 4-10 membered heterocycloalkyl groups containing 1-3 heteroatoms selected from N, O, and S, wherein the alkylene group, alkenylene group, alkylylene group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group optionally further contain 1-4 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-4 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-4 The alkyl group, alkoxy group, cycloalkyl group, and 5-6 membered heteroaryl group are selected from a selection of these groups, and the alkyl group, alkoxy group, cycloalkyl group, and heteroaryl group may be optionally further selected from a halogen, CN, OH, or C 1-4 Substituted with 1 to 4 substituents selected from alkoxy groups and NH2, W1 and W2 are independent of each other, and are joined together. 1-4 Alkylene group, -O-, -S-, -S(=O)-, -S(=O)2-, -NR W1 -, -CONR W1 -, -NR W1 CO-, -C(=O)O-, -OC(=O)-, -C(=S)-, -C(=O)-, -(C 1-4 Alkylene)-NR W1 Selected from CO-, the alkylene group can optionally be further, a halogen, =O, C1-4 Substituted with 1 to 4 groups selected from alkyl groups, CN, OH, and NH2, R W1 H, C 1-4 Selected from alkyl groups and halogens, One option is L1, [ka] Selected from, [ka] The terminal end is connected to ring B, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -SO2-C 1-4 Alkyl alkyl group, -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, [ka] Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Alkyl alkyl group, -C 1-4 Alkylhydroxy group, -C(=O)C 1-4 Alkyl, halo C 1-4 Substituted with 1 to 5 groups selected from alkyl groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Alkyl alkyl group, -C 1-4 Alkylhydroxy group, -C(=O)C 1-4 Alkyl, halo C 1-4 Substituted with 1 to 5 groups selected from alkyl groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Alkyl alkyl group, -C 1-4 Substituted with 1 to 5 groups selected from alkylhydroxy groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 5 groups selected from alkyl groups, In some embodiments, R AThese are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -NR aa R bb Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Selected from cycloalkyl groups, the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, -O-haloC 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. A C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R B These are, independently, halogen, CN, =O, OH, -SF5, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Selected from alkynyl groups, the alkyl group, alkoxy group, alkenyl group, and alkynyl group may optionally be further selected from halogens and C 1-2 Substituted with a group selected from alkyl groups, R C These are D, halogen, CN, =O, OH, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4 Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -OC 5-11 Spirocycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a-(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocyclyl), -C(=O)NR a -(4-6 member heterocycline), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, spirocycloalkyl group, and heterocyclyl group may be further optionally replaced with halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are D, halogen, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-3 Alkoxy group, C 3-4 Cycloalkyl group, 5-6 membered heteroaryl group, CN, =O, -NH-S(=O)2-C 1-2Alkyl group, -O-(5-6 member heteroaryl), -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), [ka] Selected from, the alkyl group, heteroaryl group, and cycloalkyl group may optionally be further, halogen, C 1-2 Alkyl, halo C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are D, halogen, CN, =O, OH, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4 Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a-(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocyclyl), -C(=O)NR a -(4-6 member heterocycline), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, cycloalkyl group, and heterocyclyl group may be further optionally replaced with halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are, independently, halogen, CN, =O, OH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocyclyl), -C(=O)NR a -(4-6 member heterocycline), [ka] -C(=O)-C 3-6Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, cycloalkyl group, and heterocyclyl group may be further optionally replaced with halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are, independently, halogen, CN, =O, OH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4 Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocyclyl), -C(=O)NR a -(4-6 member heterocycline), [ka] Selected from, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, cycloalkyl group, heterocyclyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C These are, independently, halogen, CN, =O, OH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a Selected from C(=O)-(4-6 membered heterocyclyl), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cycloalkyl group can optionally be further selected from halogens, OH, NH2, CN, and C. 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C These are, independently, halogen, CN, =O, OH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4 Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cycloalkyl group may optionally be further a halogen, OH, NH2, CN, or C 1-4Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, n is independently selected from 0 or 1. R a H, halogen, 3-6 membered cycloalkyl group, C 1-4 Selected from alkyl groups and halo-3 to 6-membered cycloalkyl groups, in some embodiments, R a H, halogen, 3-6 membered cycloalkyl group, C 1-4 Selected from alkyl groups, R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkylhydroxy group, Halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, or R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, As one option, R aa , R bb C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. C C 3-6A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, As one option, R B , R C C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 It is substituted with 1 to 4 groups selected from alkyl groups.

[0005] Furthermore, the compound shown in formula (I) of Technical Proposal 1, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, [ka] A is selected from a 3-20 membered heterocycloalkyl group or a 5-20 membered heteroaryl group, the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the heterocyclic group and heteroaryl group optionally contain 0-5 R A Replaced by, B is bond, C 3-10 Cycloalkyl groups, C 6-12 Selected from an aryl group, a 3-12 membered heterocycloalkyl group, or a 5-12 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, aryl group, heterocyclyl group, and heteroaryl group optionally contain 0-5 R B Replaced by, C is C 3-12 Cycloalkyl groups, C 6-10Selected from an aryl group, a 3-12 membered heterocycloalkyl group, or a 5-12 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, heterocycloalkyl group, aryl group, and heteroaryl group optionally contain 0-5 R C Replaced by, L1 and L2 are independent of each other, W1-R L - Selected from W2, the left side of L1 is connected to A, and the left side of L2 is connected to B, R L is a bond, C 1-4 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, C 3-6 Selected from cycloalkyl groups, 5-12 membered heteroaryl groups, and 4-10 membered heterocycloalkyl groups containing 1-3 heteroatoms selected from N, O, and S, wherein the alkylene group, alkenylene group, alkylylene group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group optionally further contain 1-4 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-4 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-4 The alkyl group, alkoxy group, cycloalkyl group, and 5-6 membered heteroaryl group are selected from a selection of these groups, and the alkyl group, alkoxy group, cycloalkyl group, and heteroaryl group may be optionally further selected from a halogen, CN, OH, or C 1-4 Substituted with 1 to 4 substituents selected from alkoxy groups and NH2, W1 and W2 are independent of each other, and are joined together. 1-4 Alkylene group, -O-, -S-, -S(=O)-, -S(=O)2-, -NR W1 -, -CONR W1 -, -NR W1 CO-, -C(=O)O-, -OC(=O)-, -C(=S)-, -C(=O)-, -(C 1-4 Alkylene)-NR W1 Selected from CO-, the alkylene group can optionally be further, a halogen, =O, C1-4 Substituted with 1 to 4 groups selected from alkyl groups, CN, OH, and NH2, R W1 H, C 1-4 Selected from alkyl groups and halogens, One option is L1, [ka] Selected from, [ka] The terminal end is connected to ring B, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Selected from cycloalkyl groups, the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, -O-haloC 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. A C 3-6 A cycloalkyl group or a 4-10 member heterocycloalkyl group is formed, and the cycloalkyl group or heterocycloalkyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R B These are, independently, halogen, CN, =O, OH, -SF5, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6Selected from alkynyl groups, the alkyl group, alkoxy group, alkenyl group, and alkynyl group may optionally be further selected from halogens and C 1-2 Substituted with a group selected from alkyl groups, R C These are, independently, halogen, CN, =O, OH, and C. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 3-5 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4 Alkynyl group, -SCF3, -SF5, 5-6 membered heteroaryl group, 8-10 membered bicyclic heteroaryl group, 4-12 membered heterocycloalkyl group, -N=S(=O)RaaRbb, -P(=O)RaaRbb, -NRaS(=O)2C 1-4 Alkyl group, -NRaP(=O)(C 1-4 Alkyl)2,-NRaS(=O)2NRaaRbb,-NRaC(=O)-C 3-6 Cycloalkyl group, -C(=O)NRa-C 3-6 Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cycloalkyl group may optionally be further a halogen, OH, NH2, CN, or C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R a H, halogen, 3-6 membered cycloalkyl group, C 1-4 Selected from alkyl groups, Raa and Rbb are independently H, halogen, =O, and C, respectively. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, As one option, Raa, Rbb, along with the carbon atoms bonded to them, C 3-6A carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group may optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. C C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, As one option, R B , R C C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 It is substituted with 1 to 4 groups selected from alkyl groups.

[0006] Furthermore, Technical Proposal 1 provides the compound shown in formula (I), its stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts. [ka] A is selected from a 3-20 membered heterocyclyl group or a 5-20 membered heteroaryl group, the heterocyclyl group containing 1-5 heteroatoms selected from N, O, and S, and the heterocyclyl group and heteroaryl group optionally contain 0-5 R A Replaced by, B is bond, C 3-10 Cycloalkyl groups, C 6-12 Selected from an aryl group, a 3-12 membered heterocyclyl group, or a 5-12 membered heteroaryl group, wherein the heterocyclyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, aryl group, heterocyclyl group, and heteroaryl group optionally contain 0-5 R BReplaced by, C is C 3-12 Cycloalkyl groups, C 6-10 Selected from an aryl group, a 3-12 membered heterocyclyl group, or a 5-12 membered heteroaryl group, wherein the heterocyclyl group and heteroaryl group contain 1-5 heteroatoms selected from N, O, and S, and the cycloalkyl group, heterocyclyl group, aryl group, and heteroaryl group optionally contain 0-5 R C Replaced by, L1 and L2 are independent of each other, W1-R L - Selected from W2, the left side of L1 is connected to A, and the left side of L2 is connected to B, R L is a bond, C 1-4 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, C 3-6 Selected from cycloalkyl groups, 5-12 membered heteroaryl groups, and 4-10 membered heterocycloalkyl groups containing 1-3 heteroatoms selected from N, O, and S, wherein the alkylene group, alkenylene group, alkylylene group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group optionally further contain 1-4 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-4 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-4 An alkoxy group is selected from a 3-6 membered cycloalkyl group, and the alkyl group, alkoxy group, and cycloalkyl group are optionally further substituted with 1-4 substituents selected from halogens, CN, OH, and NH2. W1 and W2 are independent of each other, and are joined together. 1-4 Alkylene group, -O-, -S-, -S(=O)-, -S(=O)2-, -NR W1 -, -CONR W1 -, -NR W1 CO-, -C(=O)O-, -OC(=O)-, -C(=S)-, -C(=O)-, -(C 1-4 Alkylene)-NR W1Selected from CO-, the alkylene group can optionally be further, a halogen, =O, C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, CN, OH, and NH2, R W1 H, C 1-4 Selected from alkyl groups and halogens, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 2-6 Alkenyl group, C 2-6 The alkyl group, alkenyl group, alkynyl group, heteroaryl group are selected from alkynyl groups and 5-12 membered heteroaryl groups, and the alkyl group, alkenyl group, alkynyl group, and heteroaryl group can be optionally further selected from halogens, OH, NH2, CN, and -O-haloC. 1-4 Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. A C 3-6 A cycloalkyl group or a 4-10 member heterocycloalkyl group is formed, and the cycloalkyl group or heterocycloalkyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R B These are, independently, halogen, CN, =O, OH, -SF5, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Selected from alkynyl groups, the alkyl group, alkoxy group, alkenyl group, and alkynyl group may optionally be further selected from halogens and C 1-2 Substituted with a group selected from alkyl groups, R C These are, independently, halogen, CN, =O, OH, and C. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 3-5 Cycloalkyl groups, C 2-4 Alkenyl group, C 2-4The alkyl group, cycloalkyl group, or heteroaryl group is selected from -SCF3, -SF5, and 5-6 membered heteroaryl groups, and the alkyl group, cycloalkyl group, or heteroaryl group can be optionally further selected from halogens, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. C C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, As one option, R B , R C C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 It is substituted with 1 to 4 groups selected from alkyl groups.

[0007] As one specific technical example of the present invention, we provide a compound of formula (I), its stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, where, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, a 9-10 member bicyclic heteroaryl group, a 10-14 member tricyclic heterocycloalkyl group, and a 10-14 member tricyclic heteroaryl group, and the heterocycloalkyl group and heteroaryl group optionally have 1-5 R A Substituted with, in some embodiments, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, or a 10-14 member tricyclic heterocycloalkyl group, and the heterocycloalkyl group or heteroaryl group is optionally 1-5 R A Replaced by, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -SO2-C 1-4 Alkyl alkyl group, -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, [ka] Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl alkyl group, C 1-2 Alkoxy group, -C 1-2 Alkylhydroxy group, -C(=O)C 1-2 Alkyl, halo C 1-2 Substituted with 1 to 5 groups selected from alkyl groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl alkyl group, C 1-2 Alkoxy group, -C 1-2 Substituted with 1 to 5 groups selected from alkylhydroxy groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl alkyl group, C 1-2 Substituted with 1 to 5 groups selected from alkoxy groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -NR aa R bb Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl alkyl group, C 1-2 Substituted with 1 to 5 groups selected from alkoxy groups, In some embodiments, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Selected from cycloalkyl groups, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Substituted with 1 to 5 groups selected from alkyl groups, One option is two R's. AC 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, B is a bond, a 4-7 member monocyclic heterocycloalkyl group, C 3-8 Selected from cycloalkyl groups, 5-6 membered heteroaryl groups, 5-6 membered heterocycloalkyl groups condensed from 5-6 membered heteroaryl groups, 5-12 membered spirocyclic heterocycloalkyl groups, 3-6 membered cycloalkyl group condensed from 5-6 membered heterocycloalkyl groups, and benzo-5-6 membered heterocycloalkyl groups, wherein the heterocycloalkyl group, heteroaryl group, cycloalkyl group, and aryl group optionally have 1-5 R groups. B Substituted with, in some embodiments, B is a bond, a 4-7 member monocyclic heterocycloalkyl group, C 3-8 Selected from cycloalkyl groups, 5-6 membered heteroaryl groups, 5-6 membered heterocycloalkyl groups condensed with 5-6 membered heteroaryl groups, 5-12 membered spirocyclic heterocycloalkyl groups, 5-6 membered cycloalkyl group condensed with 5-6 membered heterocycloalkyl groups, and benzo-5-6 membered heterocycloalkyl groups, wherein the heterocycloalkyl group, heteroaryl group, cycloalkyl group, and aryl group optionally have 1 to 5 R groups. B Replaced by, R B These are, independently, halogen, =O, and C. 1-2 Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group, a phenyl group-condensed 4-6 member carbocyclyl group, a phenyl group-condensed 4-6 member heterocycloalkyl group, a 5-6 member heterocycloalkyl group-condensed 5-6 member heteroaryl group, a 5-6 member heteroaryl group-condensed 5-6 member carbocyclyl group, an 8-12 member tricyclic cycloalkyl group, and an 8-14 member tricyclic heterocyclyl group. The heteroaryl group, heterocycloalkyl group, and heterocyclyl group contain 1-4 heteroatoms selected from N, O, and S. The phenyl group, heterocycloalkyl group, and carbocyclyl group optionally contain 1-5 R atoms. C Substituted by, in some embodiments, C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group, a phenyl group condensed into a 4-6 member carbocyclyl group, a 5-6 member heterocycloalkyl group condensed into a 5-6 member heteroaryl group, a 5-6 member heteroaryl group condensed into a 5-6 member carbocyclyl group, an 8-12 member tricyclic cycloalkyl group, or an 8-14 member tricyclic heterocyclyl group, wherein the heteroaryl group, heterocycloalkyl group, or heterocyclyl group contains 1-4 heteroatoms selected from N, O, and S, and the phenyl group, heterocycloalkyl group, or carbocyclyl group optionally contains 1-5 R C Substituted by, in some embodiments, C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group condensed into a 4-6 member carbocyclyl group, a 5-6 member heterocycloalkyl group condensed into a 5-6 member heteroaryl group, a 5-6 member heteroaryl group condensed into a 5-6 member carbocyclyl group, and an 8-12 member tricyclic cycloalkyl group, wherein the heterocycloalkyl group contains 1-3 heteroatoms selected from N, O, and S, and the phenyl group, heterocycloalkyl group, and carbocyclyl group optionally contain 1-5 R C Replaced by, R C These are D, halogen, CN, =O, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -OC 5-11 Spirocycloalkyl groups, -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a -(4-6 member heteroaryl), -C(=O)NR a -(4-6 member heterocycloalkyl), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, spirocycloalkyl group, and heterocyclyl group may be further optionally replaced with halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are D, halogen, CN, =O, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NRa -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a -(4-6 member heteroaryl), -C(=O)NR a -(4-6 member heterocycloalkyl), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further selected from halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are, independently, halogen, CN, =O, and C. 1-2 Alkyl alkyl group, C1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a-(4-6 member heteroaryl), -C(=O)NR a -(4-6 member heterocycloalkyl), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further selected from halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are, independently, halogen, CN, =O, and C. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a -(4-6 member heteroaryl), -C(=O)NR a -(4-6 member heterocycloalkyl), [ka] Selected from, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C These are, independently, halogen, CN, =O, and C. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2Alkyl, halo C 1-2 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR aSelected from C(=O)-(5-6 member heteroaryl), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group can optionally be further selected from halogens, OH, NH2, CN, and C. 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C These are, independently, halogen, CN, =O, and C. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further a halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R a H, halogen, 3-6 membered cycloalkyl group, C 1-2 Selected from alkyl groups and halo-3 to 6-membered cycloalkyl groups, in some embodiments, R a H, halogen, 3-6 membered cycloalkyl group, C 1-2 Selected from alkyl groups, R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkylhydroxy group, Halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, In some embodiments, R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, As one option, R aa , R bb C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, As one option, R B , R CThese, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group can optionally be further bonded to a halogen, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, L1 is bond, C 1-2 Alkylene group, -C(=O)-C 1-2 Alkylene-,-N(C) 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-C 2-4 Alkenylene group, -C(=O)-NH-, -C(=O)-N(CH3)-, -C(=O)-O-, 5-6 member heteroaryl -C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C1-2 Alkoxy group, Halo C 1-2 Alkoxy group, 3-6 membered cycloalkyl group, 5-6 membered heteroaryl group, C 1-2 Alkyl-C 1-2 Selected from alkoxy, in some embodiments, L1 is bonded to C 1-2 Alkylene group, -C(=O)-C 1-2 Alkylene-,-N(C) 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-C 2-4 Alkenylene group, -C(=O)-NH-, -C(=O)-O-, 5-6 member heteroaryl -C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C1-2 Alkoxy group, Halo C 1-2 Alkoxy group, 3-6 membered cycloalkyl group, 5-6 membered heteroaryl group, C 1-2 Alkyl-C 1-2 Selected from alkoxy, in some embodiments, L1 is bonded to C 1-2 Alkylene group, -C(=O)-C 1-2 Alkylene-,-N(C) 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-NH-, 5-6 member heteroaryl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2Alkoxy group, 3-6 membered cycloalkyl group, 5-6 membered heteroaryl group, C 1-2 Alkyl-C 1-2 Selected from alkoxy, One option is L1, [ka] Selected from, [ka] The terminal end is connected to ring B, L2 is a bond, C 1-2 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2 The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, The condition is that if L2 is selected from -O- or -NH-, then L1 is not selected from -C(=O)-, or B1 is not selected from the join.

[0008] Furthermore, Technical Proposal 2 provides a compound of formula (I), its stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, where, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, or a 10-14 member tricyclic heterocycloalkyl group, and the heterocycloalkyl group or heteroaryl group optionally has 1-5 R A Replaced by, R A These are, independently, halogen, =O, CN, OH, COOH, and C.1-4 Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl alkyl group, C 1-2 Alkoxy group, -C 1-2 Alkylhydroxy group, -C(=O)C 1-2 Alkyl, halo C 1-2 Substituted with 1 to 5 groups selected from alkyl groups, or R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6Selected from cycloalkyl groups, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Substituted with 1 to 5 groups selected from alkyl groups, B is selected from a bond, a 4-7 member monocyclic heterocycloalkyl group, a 3-8 member cycloalkyl group, a 5-6 member heteroaryl group, a 5-6 member heterocycloalkyl group condensed with a 5-6 member heteroaryl group, a 5-12 member spirocyclic heterocycloalkyl group, a 5-6 member cycloalkyl group condensed with a 5-6 member heterocycloalkyl group, and a benzo-5-6 member heterocycloalkyl group, wherein the heterocycloalkyl group, heteroaryl group, cycloalkyl group, and aryl group optionally have 1-5 R B Replaced by, R B These are, independently, halogen, =O, and C. 1-2 Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group condensed into a 4-6 member carbocyclyl group, a 5-6 member heterocycloalkyl group condensed into a 5-6 member heteroaryl group, a 5-6 member heteroaryl group condensed into a 5-6 member carbocyclyl group, and an 8-12 member tricyclic cycloalkyl group, wherein the heterocycloalkyl group contains 1-3 heteroatoms selected from N, O, and S, and the phenyl group, heterocycloalkyl group, and carbocyclyl group optionally contain 1-5 R C Replaced by, R C These are, independently, halogen, CN, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)RaaRbb, -P(=O)RaaRbb, -NRaS(=O)2C 1-4 Alkyl group, -NRaP(=O)(C 1-4 Alkyl)2,-NRaS(=O)2NRaaRbb,-NRaC(=O)-C 3-6 Cycloalkyl group, -C(=O)NRa-C 3-6Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further a halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R a H, halogen, 3-6 membered cycloalkyl group, C 1-2 Selected from alkyl groups, Raa and Rbb are independently H, halogen, =O, and C, respectively. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, As one option, Raa, Rbb, along with the carbon atoms bonded to them, C 3-6 A carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group may optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, As one option, R B , R C These, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group can optionally be further bonded to a halogen, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, L1 is bond, C 1-2 Alkylene group, -C(=O)-C 1-2 Alkylene-,-N(C) 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-NH-, 5-6 member heteroaryl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkoxy group, 3-6 membered cycloalkyl group, 5-6 membered heteroaryl group, C 1-2 Alkyl-C 1-2 Selected from alkoxy, R W1 H, C 1-4 Selected from alkyl groups and halogens, One option is L1, [ka] Selected from, [ka] The terminal is linked to the B ring, L2 is bonded, C 1-2 Alkylene group, C 2-4 Alkenylene group, C 2-4Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2 The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, The condition is that if L2 is selected from -O- or -NH-, then L1 is not selected from -C(=O)-, or B1 is not selected from the join.

[0009] Furthermore, Technical Proposal 2 provides the compound shown in formula (I), its stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, where A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocyclyl group, and a 10-14 member tricyclic heterocyclyl group, and the heterocyclyl group and heteroaryl group are optionally comprised of 1-5 R A Replaced by, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Selected from alkyl groups and 5-6 membered heteroaryl groups, the alkyl group and heteroaryl group may optionally be further selected from halogens, OH, NH2, CN, and C. 1-4 Substituted with 1 to 5 groups selected from alkyl groups, B is selected from a bond, a 4-7 member monocyclic heterocycloalkyl group, a 3-8 member cycloalkyl group, a 5-6 member heteroaryl group, a 5-6 member heterocyclyl group formed by the condensation of a 5-6 member heteroaryl group, a 5-12 member spirocyclic heterocycloalkyl group, a 5-6 member cycloalkyl group formed by the condensation of a 5-6 member heterocycloalkyl group, and a benzo-5-6 member heterocyclyl group, wherein the heterocyclyl group, heteroaryl group, cycloalkyl group, and aryl group optionally have 1-5 R BReplaced by, R B These are, independently, halogen, =O, and C. 1-2 Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group condensed into a 4-6 member carbocyclyl group, a 5-6 member heteroaryl group condensed into a 5-6 member heterocyclyl group, a 5-6 member carbocyclyl group condensed into a 5-6 member heteroaryl group, and an 8-12 member tricyclic cycloalkyl group, wherein the heterocyclyl group contains 1-3 heteroatoms selected from N, O, and S, and the phenyl group, heterocyclyl group, and carbocyclyl group optionally contain 1-5 R C Replaced by, R C These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Selected from alkyl groups and 5-6 membered heteroaryl groups, the alkyl group and heteroaryl group may optionally be further replaced with halogens and C 1-2 Substituted with 1 to 5 groups selected from alkyl groups, As one option, R B , R C These, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group can optionally be further bonded to a halogen, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, L1 is bond, C 1-2 Alkylene group, -C(=O)-C 1-2 Alkylene-,-N(C) 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-NH-, 5-6 member heteroaryl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, L2 is a bond, C 1-2 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2 The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, The condition is that if L2 is selected from -O- or -NH-, then L1 is not selected from -C(=O)-, or B1 is not selected from the join.

[0010] One specific technical proposal 3 of the present invention is a compound described in proposal 1 or proposal 2, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocyclyl group, and a 10-14 member tricyclic heterocyclyl group, and the heterocyclyl group and heteroaryl group are optionally comprised of 1-5 R A Replaced by, R A These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Selected from alkyl groups and 5-6 membered heteroaryl groups, the alkyl group and heteroaryl group may optionally be further selected from halogens, OH, NH2, CN, and C. 1-4 It is substituted with 1 to 5 groups selected from alkyl groups.

[0011] One specific technical proposal 4 of the present invention is a compound described in proposal 1 or proposal 2, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, B is selected from a bond, a 4-7 member monocyclic heterocycloalkyl group, a 3-8 member cycloalkyl group, a 5-6 member heteroaryl group, a 5-6 member heterocyclyl group formed by the condensation of a 5-6 member heteroaryl group, a 5-12 member spirocyclic heterocycloalkyl group, a 5-6 member cycloalkyl group formed by the condensation of a 5-6 member heterocycloalkyl group, and a benzo-5-6 member heterocyclyl group, wherein the heterocyclyl group, heteroaryl group, cycloalkyl group, and aryl group optionally have 1-5 R B Replaced by, R B These are, independently, halogen, =O, and C. 1-2 A alkyl group is selected, and the alkyl group is optionally further substituted with a halogen.

[0012] One specific technical proposal 5 of the present invention is a compound described in proposal 1 or proposal 2, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group condensed into a 4-6 member carbocyclyl group, a 5-6 member heteroaryl group condensed into a 5-6 member heterocyclyl group, a 5-6 member carbocyclyl group condensed into a 5-6 member heteroaryl group, and an 8-12 member tricyclic cycloalkyl group, wherein the heterocyclyl group contains 1-3 heteroatoms selected from N, O, and S, and the phenyl group, heterocyclyl group, and carbocyclyl group optionally contain 1-5 R C Replaced by, R C These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Selected from alkyl groups and 5-6 membered heteroaryl groups, the alkyl group and heteroaryl group may optionally be further replaced with halogens and C 1-2 It is substituted with 1 to 5 groups selected from alkyl groups.

[0013] One specific technical proposal 6 of the present invention is a compound described in proposal 1 or proposal 2, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, As one option, R B , R C These, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group can optionally be further bonded to a halogen, C 1-2 It is substituted with 1 to 4 groups selected from alkyl groups.

[0014] One specific technical proposal 7 of the present invention is a compound described in proposal 1 or proposal 2, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, L1 is bond, C 1-2 Alkylene group, -C(=O)-C 1-2 Alkylene-,-N(C) 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-NH-, 5-6 member heteroaryl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, L2 is a bond, C 1-2 Alkylene group, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2 The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, The condition is that if L2 is selected from -O- or -NH-, then L1 is not selected from -C(=O)-, or B1 is not selected from the join.

[0015] As one specific technical proposal 8 of the present invention, a compound of formula (I), its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt described in any one of technical proposals 1 to 7, having the structures of formulas (I-1a), (I-2), (I-3), (I-4), (I-5), (I-1b), [ka] A1 is [ka] Selected from the basis, Or A1 is, [ka] Selected from the basis, Or A1 is, [ka] Selected from the basis, Or A1 is, [ka] Selected from the basis, Or A1 is, [ka] Selected from the basis, Or A1 is, [ka] Selected from the basis, Or A1 is, [ka] Selected from the basis, B1 is a bond, [ka] Selected from the basis, Or B1 is, [ka] Selected from the basis, Or B1 is, [ka] Selected from the basis, Here, [ka] The terminal is L1 or L 1a or L 1b It is connected to, [ka] The terminal is L2 or L 2a It is connected to, C1 is [ka] Selected from the basis, C2 is [ka] Selected from the basis, Or C2 is, [ka] Selected from the basis, Or C2 is, [ka] Selected from the basis, or C2 is, [ka] Selected from the basis, or C2 is, [ka] Selected from the basis, or C2 is, [ka] Selected from the basis, As a condition, C2 [ka] If selected from, L2 is not selected from the join, or C2 is [ka] If selected from and L2 is selected from join, then n3 is not selected from 0, R C It is not F, R1, R2, R3, and R4 are each independently selected from H and halogen, and the condition is that R1, R2, R3, and R4 cannot be selected from H simultaneously. One option is that R3 and R4 combine to form = O. Equation (I-3) satisfies one or more of the following conditions: (1), L 1a is a bond, C 1-2 Alkylene group, -C(=O)-CH(CH3)-, -C(=O)-C(R a R b )-,-N(C 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-24-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-C 2-4 Alkenylene group, -C(=O)-NH-, -C(=O)-N(CH3)-, -C(=O)-O-, 5-6 member heteroaryl -C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from an alkoxy group and a 3-6 membered cycloalkyl group, in some embodiments, L 1a is a bond, C 1-2 Alkylene group, -C(=O)-CH(CH3)-, -C(=O)-C(R a R b )-,-N(C 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-24-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, -C(=O)-C 2-4 Alkenylene group, -C(=O)-NH-, -C(=O)-O-, 5-6 member heteroaryl -C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from an alkoxy group and a 3-6 membered cycloalkyl group, in some embodiments, L 1a is a bond, C 1-2 Alkylene group, -C(=O)-CH(CH3)-, -C(=O)-C(R a R b )-,-N(C 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C 1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-24-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, 5-6 member heteroaryl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, L 1a The right side is connected to the B1 ring, R a , R b These are, independently, H, halogen, 3-6 membered cycloalkyl group, and C. 1-2 Selected from alkyl groups, with the condition being R a , R b It is not selected from H at the same time. L 2a is a bond, C 2-4 Alkenylene group, C 2-4 Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, the condition is L 1a is selected from -C(=O)-, L 2a If -NH- or -O- is selected, B1 is not selected from the bond. (2), L 1a It is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-, L 2a If selected from the join, then at least one R C1 These are =O, 5-6 member heteroaryl groups, 8-10 member bicyclic heteroaryl groups, 4-12 member heterocycloalkyl groups, -N=S(=O)RaaRbb, -P(=O)RaaRbb, -NRaS(=O)2C 1-4 Alkyl group, -NRaP(=O)(C 1-4 Alkyl)2,-NRaS(=O)2NRaaRbb,-NRaC(=O)-C 3-6 Cycloalkyl group, -C(=O)NRa-C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, cubanes, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NRa C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocyclyl), -C(=O)NR a -(4-6 member heteroaryl), [ka] Selected from the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cubane, optionally further include halogens, OH, NH2, CN, and C. 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, L 1a It is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-, L 2a If selected from the join, then at least one R C1 These are =O, 5-6 member heteroaryl groups, 8-10 member bicyclic heteroaryl groups, 4-12 member heterocycloalkyl groups, -N=S(=O)RaaRbb, -P(=O)RaaRbb, -NRaS(=O)2C 1-4 Alkyl group, -NRaP(=O)(C 1-4 Alkyl)2,-NRaS(=O)2NRaaRbb,-NRaC(=O)-C 3-6 Cycloalkyl group, -C(=O)NRa-C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a-(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, cubanes, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a Selected from C(=O)-(4-6 membered heterocyclyl), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cubane can be optionally further replaced with halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, L 1a It is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-, L 2a If selected from the join, then at least one R C1 These are =O, 5-6 member heteroaryl groups, 8-10 member bicyclic heteroaryl groups, 4-12 member heterocycloalkyl groups, -N=S(=O)RaaRbb, -P(=O)RaaRbb, -NRaS(=O)2C 1-4 Alkyl group, -NRaP(=O)(C 1-4 Alkyl)2,-NRaS(=O)2NRaaRbb,-NRaC(=O)-C 3-6 Cycloalkyl group, -C(=O)NRa-C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Selected from cycloalkyl groups and cubane, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cubane may optionally be further replaced with halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, preferably L 1a It is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-, L 2a If selected from the join, then at least one R C1 These are 5-6 member heteroaryl groups, 8-10 member bicyclic heteroaryl groups, 4-12 member heterocycloalkyl groups, -N=S(=O)RaaRbb, -P(=O)RaaRbb, and -NRaS(=O)2C 1-4 Alkyl group, -NRaP(=O)(C 1-4 Alkyl)2,-NRaS(=O)2NRaaRbb,-NRaC(=O)-C 3-6 Cycloalkyl group, -C(=O)NRa-C 3-6 Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further a halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, (3), L 1a It is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-, L 2a C 1-2 Alkylene group, C 2-4 Alkenylene group, C2-4 Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2 The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, (4), L 1a It is selected from -C(=O)-CH2-, L 2a If selected from the join, then at least one R A is C 1-2 If an alkyl group is not selected, the compound [ka] Instead, L 1b The nucleotide is selected from a bond, a 4-6 member monocyclic heterocycloalkyl group, and -C(=O)-NH-, and the heterocycloalkyl group can optionally be further a halogen, =O,C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, As one option, [ka] teeth, [ka] Selected from, R A These are, independently, halogen, =O, and C. 1-2 Alkyl group, -CF3, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C1-2 Alkyl-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -SO2-C 1-2 Alkyl alkyl group, -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, [ka] The alkyl group is selected from, and optionally further, OH, NH2, CN, C 1-2 Alkyl alkyl group, C 1-2 The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, NH2, CN, and C. 1-2 Alkyl alkyl group, -C 1-2 Alkylhydroxy, Halo C 1-2 Alkyl group, -C(=O)C 1-2 Alkyl alkyl group, C 1-2 Substituted with 1 to 4 groups selected from alkoxy groups, In some embodiments, R A These are, independently, halogen, =O, and C. 1-2 Alkyl group, -CF3, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-2Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] The alkyl group is selected from, and optionally further, OH, NH2, CN, C 1-2 Alkyl alkyl group, C 1-2 The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, NH2, CN, and C. 1-2 Alkyl alkyl group, -C 1-2 Alkylhydroxy, Halo C 1-2 Alkyl group, -C(=O)C 1-2 Alkyl alkyl group, C 1-2 Substituted with 1 to 4 groups selected from alkoxy groups, In some embodiments, R A These are, independently, halogen, =O, and C. 1-2 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NRaa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C 3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] The alkyl group is selected from, and optionally further, OH, NH2, CN, C 1-2 Alkyl alkyl group, C 1-2 The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, NH2, CN, and C. 1-2 Alkyl alkyl group, -C 1-2 Alkylhydroxy group, Halo C 1-2 Alkyl group, -C(=O)C 1-2 Alkyl alkyl group, C 1-2 Substituted with 1 to 4 groups selected from alkoxy groups, In some embodiments, R A These are, independently, halogen, =O, and C. 1-2 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb , -C 3-6 Cycloalkyl groups, -NR aa -C3-6 Cycloalkyl groups, 5-6 membered heteroaryl groups, [ka] The alkyl group is selected from, and optionally further, OH, NH2, CN, C 1-2 Alkyl alkyl group, C 1-2 The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, NH2, CN, and C. 1-2 Alkyl alkyl group, -C 1-2 Substituted with 1 to 4 groups selected from alkylhydroxy groups, In some embodiments, R A These are, independently, halogen, =O, and C. 1-2 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb The alkyl group is selected from, and optionally further, OH, NH2, CN, C 1-2 Alkyl alkyl group, C 1-2 The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, NH2, CN, and C. 1-2 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R AThese are, independently, halogen, =O, and C. 1-2 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -NR aa R bb The alkyl group is selected from, and optionally further, OH, NH2, CN, C 1-2 Alkyl alkyl group, C 1-2 The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, NH2, CN, and C. 1-2 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R A These are independent of each other: =O, C 1-2 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Selected from cycloalkyl groups and 4- to 12-membered heterocycloalkyl groups, wherein the alkyl group can optionally be further NH2, CN, or C. 1-2 Substituted with 1 to 4 groups selected from alkyl groups, wherein the heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further substituted with halogens, OH, NH2, CN, or C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, R A1 These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -SO2-C 1-4 Alkyl group, -NRaco-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -NR aa R bb Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4Alkyl, halo C 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 5 groups selected from alkoxy groups, in some embodiments, R A1 These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-(5-6 member heteroaryl), -NR aa R bb Selected from, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 5 groups selected from alkoxy groups, in some embodiments, R A1 These are, independently, halogen, =O, CN, OH, COOH, and C. 1-4 Alkyl group, 5-6 member heteroaryl group, -NRaCO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Selected from cycloalkyl groups, the alkyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Substituted with 1 to 5 groups selected from alkyl groups, One option is two R's. A C 3-6 A 4-6 membered carbocyclyl group or a 4-6 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, R B These are, independently, halogen, =O, and C. 1-2Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. R C These are D, halogen, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-3 Alkoxy group, C 3-4 Cycloalkyl group, 5-6 membered heteroaryl group, CN, =O, -NH-S(=O)2-C 1-2 Alkyl group, -O-(5-6 member heteroaryl), -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), [ka] Selected from, the alkyl group, heteroaryl group, and cycloalkyl group may optionally be further, halogen, C 1-2 Alkyl, halo C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are D, halogen, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, 5-6 membered heteroaryl group, CN, =O, -NH-S(=O)2-C 1-2 Alkyl group, -O-(5-6 member heteroaryl), -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), [ka] Selected from, the alkyl group, heteroaryl group, and cycloalkyl group may optionally be further, halogen, C 1-2 Alkyl, halo C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are D, halogen, and C, respectively, independently. 1-2Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, 5-6 membered heteroaryl group, CN, =O, -NH-S(=O)2-C 1-2 Alkyl group, -O-(5-6 member heteroaryl), -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), [ka] Selected from, the alkyl group, heteroaryl group, and cycloalkyl group may optionally be further, halogen, C 1-2 Alkyl, halo C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C These are, independently, halogen and C 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, Halo C 1-2 Alkyl, halo C 1-2 Alkoxy group, 5-6 membered heteroaryl group, CN, =O, -NH-S(=O)2-C 1-2 Selected from alkyl groups, the alkyl group, heteroaryl group may optionally be further, halogen, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, Preferably, R C These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Selected from alkyl groups, 5-6 membered heteroaryl groups, CN, and =O, the alkyl group and heteroaryl group may optionally be further replaced with halogens and C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, R C1 These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Alkyl, halo C 1-3 Alkoxy group, C 3-5 Cycloalkyl groups, C 6-10Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a -(5-6 member heteroaryl), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further selected from halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C1 These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a-C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a -(5-6 member heteroaryl), [ka] -C(=O)-C 3-6 Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further selected from halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, R C1 These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 3-5 Cycloalkyl groups, C 6-10Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a C(=O)-(5-6 member heteroaryl), -C(=O)NR a -(5-6 member heteroaryl), [ka] Selected from, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group may optionally be further, halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C1 These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a-(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -C 1-4 Alkyl-(C 6-10 Ariel), -C 1-4 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-4 Alkyl) n -O-(C 1-4 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocycloalkyl), -NR a Selected from C(=O)-(5-6 member heteroaryl), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group can optionally be further selected from halogens, OH, NH2, CN, and C. 1-4 Alkyl, halo C 1-4 Alkyl groups, deuterated C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C1 These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 3-5 Cycloalkyl groups, C 6-10 Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR a -C 3-6 Cycloalkyl groups, -NR a -(4-12 member heterocycloalkyl), -NR a -(5-6 member heteroaryl), -NR a S(=O)2-C 3-6 Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further a halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, Preferably, R C1 These are, independently, halogen and C 1-2 Alkyl, halo C 1-2 Alkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb, -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further a halogen, OH, NH2, CN, C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkylhydroxy group, Halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, In some embodiments, R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups, As one option, R aa , R bb C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, n1, n2, and n3 are each independently selected from 0, 1, 2, 3, 4, or 5.

[0016] Furthermore, the compounds described in Technical Proposal 8, their stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts having the structures of formulas (I-1), (I-2), (I-3), (I-4), and (I-5), [ka] A1 is [ka] Selected from the basis, B1 is a bond, [ka] Selected from the basis, Here, [ka] The end is connected to L1, [ka] The end is connected to L2, C1 is [ka] C2 is [ka] Selected from the basis, R1, R2, R3, and R4 are each independently selected from H and halogen, and the condition is that R1, R2, R3, and R4 cannot be selected from H simultaneously. One option is that R3 and R4 combine to form = O. (1), L 1a is a bond, C 1-2 Alkylene group, -C(=O)-CH(CH3)-, -C(=O)-C(R a R b )-,-N(C 1-2 Alkylene)-C(=O)-C 1-2 Alkylene-,-NH-C(=O)-C1-2 Alkylene-,-S(=O)2-C 1-2 Alkylene-, -C(=S)-C 1-2 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S 1-2 Alkylene-,-C(=O)-C 3-6 Cycloalkyl-, -C 1-2 Alkylene -C(=O)-, -C(=O)-C(=O)-, C 2-4 Alkenylene group, 5-6 member heteroaryl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C 3-6 Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C 1-2 Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C 1-2 Alkylene-,-C 1-2 Alkylene-4-6 member monocyclic heterocycloalkyl-,-C 1-2 Alkylene-NH-C(=O)-C 1-2 Selected from alkylene-, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, R a , R b These are, independently, H, halogen, 3-6 membered cycloalkyl group, and C. 1-2 Selected from alkyl groups, with the condition being R a , R b It is not selected from H at the same time. L 2a is a bond, C 2-4 Alkenylene group, C 2-4Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C 1-2 The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R L1 Replaced with R L1 These are, independently, halogen, =O, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, C 2-4 Alkenyl group, C 1-2 Alkoxy group, Halo C 1-2 Selected from alkoxy groups and 3-6 membered cycloalkyl groups, the condition is L 1a is selected from -C(=O)-, L 2a If -NH- or -O- is selected, B1 is not selected from the bond. (2), L 1a It is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-, L 2a If selected from the join, R C1 The heteroaryl group is selected from a 5-6 member heteroaryl group, and the heteroaryl group can optionally be further a halogen, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, (3), L 1a R is selected from -C(=O)-CH2- and -C(=O)-CH2CH2-. C1 If selected from -CF3, L 2a It is not a combination, L 1b The nucleotide is selected from a bond, a 4-6 member monocyclic heterocycloalkyl group, and -C(=O)-NH-, and the heterocycloalkyl group can optionally be further a halogen, =O,C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, As one option, [ka] teeth, [ka] Selected from, R A These are, independently, halogen, =O, and C. 1-2 Selected from alkyl groups and 5-6 membered heteroaryl groups, the alkyl group may optionally be further selected from halogens, OH, NH2, CN, and C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, R B These are, independently, halogen, =O, and C. 1-2 Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. R C These are, independently, halogen and halo C. 1-2 Selected from alkyl groups and 5-6 membered heteroaryl groups, the alkyl group and heteroaryl group may optionally be further replaced with halogens and C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, n1, n2, and n3 are each independently selected from 0, 1, 2, 3, 4, or 5.

[0017] One specific technical proposal 9 of the present invention is a compound of formulas (I-1a), (I-2), (I-3), (I-4), (I-5) described in proposal 7 or proposal 8, its stereoisomer, deuteride, solvate, cocrystal or pharmaceutically acceptable salt, R A These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa , cyclopropyl group, cyclobutyl group, -NH-cyclopropyl, -NH-cyclobutyl, 5-6 member heteroaryl group, [ka] The methyl group and ethyl group are selected from the above, and the methyl group and ethyl group are optionally further substituted with 1 to 4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -C(=O)CH3, -O-CH3, and -O-CH2CH3. In some embodiments, R A These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aaSelected from, the methyl group and ethyl group are optionally substituted with 1 to 4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, and in some embodiments, R A These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl),-NHR aa Selected from, the methyl group and ethyl group are optionally substituted with 1 to 4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, and in some embodiments, R A These are, independently, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 The methyl group and ethyl group are optionally substituted with 1 to 4 groups optionally selected from NH2, CN, methyl, and ethyl groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally substituted with 1 to 4 groups optionally selected from F, Cl, OH, NH2, CN, methyl, and ethyl groups. One option is two R's. A These, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group is optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group. R A1These are, independently, F, Cl, =O, CN, OH, COOH, methyl group, ethyl group, and -OC. 3-6 Cycloalkyl groups, -NHR aa Selected from, the methyl group, ethyl group, and cycloalkyl group are optionally further substituted with 1 to 5 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, and methoxy group, in some embodiments, R A1 These are, independently, F, Cl, =O, CN, OH, COOH, methyl group, ethyl group, and -OC. 3-6 Selected from cycloalkyl groups, the methyl group, ethyl group, and cycloalkyl group are optionally further substituted with 1 to 5 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group. R B Each of these is independently selected from F, Cl, =O, methyl group, and ethyl group, and the methyl group and ethyl group are optionally further substituted with F and Cl groups, respectively. R C These are independently F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCHF2, -OCH2F, -OCF3, -OCH2CF3, -OCH(CH3)CF3, cyclopropyl group, cyclobutyl group, 5-membered heteroaryl group, 6-membered heteroaryl group, -CN, =O, -NH-S(=O)2-C 1-2 Selected from alkyl groups, the methyl group, ethyl group, cyclopropyl group, cyclobutyl group, heteroaryl group, and heterocycloalkyl group are optionally substituted with 1 to 4 groups further selected from F, Cl, methyl group, and ethyl group. R C1These are, independently, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCHF2, -OCH2F, -OCF3, -OCH2CF3, -OCH(CH3)CF3, cyclopropyl group, cyclobutyl group, cyclopentyl group, cubane, 5-membered heteroaryl group, 6-membered heteroaryl group, 8-membered fused cyclic heteroaryl group, 9-membered fused cyclic heteroaryl group, 10-membered fused cyclic heteroaryl group, 7-8 membered spirocyclic heterocycloalkyl group, 8-9 membered fused cyclic heterocycloalkyl group, 7-membered crosslinked cyclic heterocycloalkyl group, 4-6 membered monocyclic heterocycloalkyl group, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-6 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NH-C 3-6 Cycloalkyl groups, -NH-(4-6 member heterocycloalkyl groups), -NH-(5-6 member heteroaryl groups), -NH-S(=O)2-C 3-6 Cycloalkyl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -C 1-2 Alkylphenyl, -C 1-2 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-2 Alkyl) n -O-(C 1-2 Alkyl) n-(4-6 member heterocyclyl), -NR a The alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cubane are optionally further selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, deuterated methyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, =O, and -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, in some embodiments, R C1 These are, independently, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, and C. 4-5 Cycloalkyl groups, cubanes, 5-membered heteroaryl groups, 6-membered heteroaryl groups, 8-membered fused heteroaryl groups, 9-membered fused heteroaryl groups, 10-membered fused heteroaryl groups, 7-8 membered spirocyclic heterocycloalkyl groups, 8-9 membered fused heterocycloalkyl groups, 7-membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-6 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NH-C 3-6Cycloalkyl groups, -NH-(4-6 member heterocycloalkyl groups), -NH-(5-6 member heteroaryl groups), -NH-S(=O)2-C 3-6 Selected from cycloalkyl groups, the cyclopropyl group, cyclobutyl group, cyclopentyl group, alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cubane can optionally be further F, Cl, OH, NH2, CN, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, =O, and -C(=O)C. 1-4 Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, R a R is selected from H, F, Cl, methyl group, ethyl group, cyclopropyl group, cyclobutyl group, cyclopentyl group, and difluorocyclobutyl group, and in some embodiments, a The group is selected from H, F, Cl, methyl group, ethyl group, cyclopropyl group, cyclobutyl group, and cyclopentyl group. R aa , R bb Each is independently selected from H, F, Cl, =O, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCH3, -OCH2CH3, -OCHF2, -OCH2F, -OCF3, -OCH2CF3, -OCH2CHF2, -OCH2CH2F, As one option, R aa , R bb These, together with the carbon atoms bonded to them, form a 4-6 membered heterocycline group, and the heterocycline group is optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group. n1 is selected from 1, 2, or 3, and in some embodiments, n1 is selected from 1, 2, or 3. n2 is selected from 0 or 1. n3 is selected from 0, 1, or 2. L1 is a bond, vinylidene group, -CH2-, -CH2-CH2-, 4-6 member monocyclic heterocycloalkyl group, (4-6 member monocyclic heterocycloalkyl group)-C(=O)-CH2-, -(4-6 member monocyclic heterocycloalkyl group)-CH2-, -CH2-(4-6 member monocyclic heterocycloalkyl group)-, -CH(CH3)NHC(=O)-CH2-, -CH2NHC(=O)-CH2-, -S(=O)2-CH2-, -C(=S)-CH2-, -C(=O)-C 3-6 Cycloalkyl groups, -C(=O)-CH(CH3)-, -C(=O)-CH(C 3-6 Cycloalkyl)-, -C(=O)-CF2-, -C(=O)-C(CH3)2-, -CH2-C(=O)-, -C(=O)-C(=O)-, C 3-6 Cycloalkyl group, -(5-6 member heteroaryl)-CH2-, 5-6 member heteroaryl group, -C(=O)-, -C(=O)-CH2-, -N(CH3)-CH2-, -CF2-CH2-, -C(=O)-C 2-4 The group is selected from alkenylene groups and -C(=O)-O-, and the -CH2-, alkenylene group, cycloalkyl group, heterocycloalkyl group, and heteroaryl group may optionally be further selected from 1 to 3 R groups. L1 Replaced with R L1 Each of these is independently selected from F, Cl, Br, =O, methyl group, ethyl group, -CF3, -CHF2, -CH2F, vinyl group, propenyl group, methoxy group, ethoxy group, -OCF3, -OCHF2, -OCH2F, cyclopropyl group, cyclobutyl group, methyl-methoxy, and a 5-membered heteroaryl group. In some embodiments, L1 is a bond, vinylidene group, -CH2-, -CH2-C H2-, 4-6 member monocyclic heterocycloalkyl, (4-6 member monocyclic heterocycloalkyl)-C(=O)-CH2-, -(4-6 member monocyclic heterocycloalkyl)-CH2-, -CH2-(4-6 member monocyclic heterocycloalkyl)-, -CH(CH3)NHC(=O)-CH2-, -CH2NHC(=O)-CH2-, -S(=O)2-CH2-, -C(=S)-CH2-, -C(=O)-C 3-6 Cycloalkyl groups, -C(=O)-CH(CH3)-, -C(=O)-CH(C 3-6Cycloalkyl)-, -C(=O)-CF2-, -C(=O)-C(CH3)2-, -CH2-C(=O)-, -C(=O)-C(=O)-, C 3-6 Selected from cycloalkyl groups, -(5-6 member heteroaryl)-CH2-, 5-6 member heteroaryl groups, -C(=O)-, -C(=O)-CH2-, -N(CH3)-CH2-, and -CF2-CH2-, the -CH2-, cycloalkyl groups, heterocycloalkyl groups, and heteroaryl groups may optionally be further further joined by 1 to 3 R groups. L1 Replaced with R L1 Each of these is independently selected from F, Cl, Br, =O, methyl group, ethyl group, -CF3, -CHF2, -CH2F, vinyl group, propenyl group, methoxy group, ethoxy group, -OCF3, -OCHF2, -OCH2F, cyclopropyl group, cyclobutyl group, methyl-methoxy, and 5-membered heteroaryl group. One option is L1, [ka] Selected from, [ka] The terminal end is connected to ring B, L2 is selected from a bond, vinylidene group, ethynylene group, -CH2-, -CH2-CH2-, -O-, -NH-, -C(=O)-, and -N(CH3)-.

[0018] Furthermore, the compound of formula (I) described in Technical Proposal 9, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, R A These are, independently, =O, methyl group, ethyl group, and -NHCO-C. 3-6The methyl group and ethyl group are optionally substituted with 1 to 4 groups optionally selected from NH2, CN, methyl, and ethyl groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally substituted with 1 to 4 groups optionally selected from F, Cl, OH, NH2, CN, methyl, and ethyl groups. R A1 These are, independently, F, Cl, =O, CN, OH, COOH, methyl group, ethyl group, and -OC. 3-6 Selected from cycloalkyl groups, the methyl group, ethyl group, and cycloalkyl group are optionally further substituted with 1 to 5 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group. R B Each of these is independently selected from F, Cl, =O, methyl group, and ethyl group, and the methyl group and ethyl group are optionally further substituted with F and Cl groups, respectively. R C Each of these groups is independently selected from F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, 5-membered heteroaryl group, 6-membered heteroaryl group, CN, and =O, and the methyl group, ethyl group, and heteroaryl group are optionally further substituted with 1 to 4 groups selected from F, Cl, methyl group, and ethyl group. R C1 These are, independently, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, 5-membered heteroaryl group, 6-membered heteroaryl group, 8-membered fused cyclic heteroaryl group, 9-membered fused cyclic heteroaryl group, 10-membered fused cyclic heteroaryl group, 7-8 membered spirocyclic heterocycloalkyl group, 8-9 membered fused cyclic heterocycloalkyl group, 7-membered crosslinked cyclic heterocycloalkyl group, 4-6 membered monocyclic heterocycloalkyl group, and -N=S(=O)R. aa R bb ,-P(=O)R aa R bb , -NR aS(=O)2C 1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Selected from cycloalkyl groups, the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group may optionally be further F, Cl, OH, NH2, CN, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, =O, -C(=O)C 1-4 Alkyl group, -NH-C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, R a The group is selected from H, F, Cl, methyl group, ethyl group, cyclopropyl group, cyclobutyl group, and cyclopentyl group. R aa , R bb Each is independently selected from H, F, Cl, =O, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCH3, -OCH2CH3, -OCHF2, -OCH2F, -OCF3, -OCH2CF3, -OCH2CHF2, -OCH2CH2F, As one option, R aa , R bb These, together with the carbon atoms bonded to them, form a 4-6 membered heterocycline group, and the heterocycline group is optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, and n1 is selected from 1, 2, or 3. n2 is selected from 0 or 1. n3 is selected from 0, 1, or 2. L1 is a bond, vinylidene group, -CH2-, -CH2-CH2-, 4-6 member monocyclic heterocycloalkyl group, (4-6 member monocyclic heterocycloalkyl group)-C(=O)-CH2-, -(4-6 member monocyclic heterocycloalkyl group)-CH2-, -CH2-(4-6 member monocyclic heterocycloalkyl group)-, -CH(CH3)NHC(=O)-CH2-, -CH2NHC(=O)-CH2-, -S(=O)2-CH2-, -C(=S)-CH2-, -C(=O)-C 3-6 Cycloalkyl groups, -C(=O)-CH(CH3)-, -C(=O)-CH(C 3-6 Cycloalkyl)-, -C(=O)-CF2-, -C(=O)-C(CH3)2-, -CH2-C(=O)-, -C(=O)-C(=O)-, C 3-6 Selected from cycloalkyl groups, -(5-6 member heteroaryl)-CH2-, 5-6 member heteroaryl groups, -C(=O)-, -C(=O)-CH2-, -N(CH3)-CH2-, and -CF2-CH2-, the -CH2-, cycloalkyl groups, heterocycloalkyl groups, and heteroaryl groups may optionally be further further joined by 1 to 3 R groups. L1 Replaced with R L1 Each of these is independently selected from F, Cl, Br, =O, methyl group, ethyl group, -CF3, -CHF2, -CH2F, vinyl group, propenyl group, methoxy group, ethoxy group, -OCF3, -OCHF2, -OCH2F, cyclopropyl group, cyclobutyl group, methyl-methoxy, and 5-membered heteroaryl group. One option is L1, [ka] Selected from, [ka] The terminal end is connected to ring B, L2 is selected from a bond, vinylidene group, ethynylene group, -CH2-, -CH2-CH2-, -O-, -NH-, -C(=O)-, and -N(CH3)-.

[0019] Furthermore, the compounds described in Technical Proposal 9, their stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, R A These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa , cyclopropyl group, cyclobutyl group, -NH-cyclopropyl, -NH-cyclobutyl, 5-6 member heteroaryl group, [ka] The methyl group and ethyl group are selected from the above, and the methyl group and ethyl group are optionally further substituted with 1 to 4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, In some embodiments, R A Each of these groups is independently selected from F, Cl, =O, a methyl group, an ethyl group, a 5-membered heteroaryl group, and a 6-membered heteroaryl group, and the methyl group, ethyl group, 5-membered heteroaryl group, and 6-membered heteroaryl group are optionally further substituted with 1 to 4 groups selected from F, Cl, a methyl group, and an ethyl group. R BEach of these is independently selected from F, Cl, =O, methyl group, and ethyl group, and the methyl group and ethyl group are optionally further substituted with F and Cl groups, respectively. R C Each of these is independently selected from F, Cl, -CF3, -CHF2, -CH2CH2F, -CH2CF3, -CH2CHF2, -CH2CH2F, a 5-membered heteroaryl group, and a 6-membered heteroaryl group, and the heteroaryl group is optionally further substituted with 1 to 4 groups selected from F, Cl, a methyl group, and an ethyl group. n1 is selected from 1, 2, or 3. n2 is selected from 0 or 1. n3 is selected from 0, 1, or 2. L1 is a bond, vinylidene group, -CH2-, 4-6 member monocyclic heterocycloalkyl, 4-6 member monocyclic heterocycloalkyl-C(=O)-CH2-, -4-6 member monocyclic heterocycloalkyl-CH2-, -CH2-4-6 member monocyclic heterocycloalkyl-, -CH(CH3)NHC(=O)-CH2-, -CH2NHC(=O)-CH2-, -S(=O)2-CH2-, -C(=S)-CH2-, -C(=O)-C 3-6 Cycloalkyl groups, -C(=O)-CH(CH3)-, -C(=O)-CH(C 3-6 Cycloalkyl)-, -C(=O)-CF2-, -C(=O)-C(CH3)2-, -CH2-C(=O)-, -C(=O)-C(=O)-, C 3-6 Selected from cycloalkyl groups, -5-6 member heteroaryl-CH2-, -5-6 member heteroaryl-, -C(=O)-, -C(=O)-CH2-, and -N(CH3)-CH2-, the -CH2-, cycloalkyl groups, heterocycloalkyl groups, and heteroaryl groups may optionally be further further joined by 1 to 3 R groups. L1 Replaced with R L1 Each of these is independently selected from F, Cl, Br, =O, methyl group, ethyl group, -CF3, -CHF2, -CH2F, vinyl group, propenyl group, methoxy group, ethoxy group, -OCF3, -OCHF2, -OCH2F, cyclopropyl group, and cyclobutyl group. L2 is selected from a bond, vinylidene group, ethynylene group, -O-, -NH-, -C(=O)-, and -N(CH3)-.

[0020] Furthermore, the compounds described in Technical Proposal 10, their stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts having the structures of formulas (I-6), (I-7), and (I-8), [ka] R C1 These are, independently, HaroC 1-2 Alkyl group, 5-6 member heteroaryl group, -OC 3-6 Selected from cycloalkyl groups, -O-4 to 6-membered heterocycloalkyl groups, and -O-5 to 6-membered heteroaryl groups, the heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further composed of halogens, OH, NH2, CN, or C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, preferably R C1 These are, independently, a 5-membered heteroaryl group, a 6-membered heteroaryl group, and -OC. 3-6 Selected from cycloalkyl groups, the heteroaryl group and cycloalkyl group are optionally further halogens, OH, NH2, CN, and C 1-4 Alkyl, halo C 1-4 Alkyl alkyl group, =O, -C(=O)C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, preferably R C1 Each of these groups is independently selected from a 5-membered heteroaryl group, -O-cyclopropyl, -O-cyclobutyl, and -O-cyclopentyl, and the pyrrolyl group, imidazolyl group, pyrazolyl group, thiazolyl group, cyclopropyl group, cyclobutyl group, and cyclopentyl group may be optionally further selected from halogens, OH, NH2, CN, and C. 1-2 Alkyl, halo C 1-2 Alkyl alkyl group, =O, -C(=O)C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, more preferably RC1 These are, independently, HaroC 1-2 The alkyl group is selected from alkyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, triazole, -O-cyclopropyl, -O-cyclobutyl, -O-cyclopentyl, -O-bicyclo[1.1.1]pentane, -O-spiro[2.3]hexane, and -O-oxacyclopentyl, and the pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, cyclopropyl, cyclobutyl, cyclopentyl, bicyclo[1.1.1]pentane, spiro[2.3]hexane, and oxacyclopentyl groups are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl, ethyl, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, and =O, more preferably R C1 Each of these groups is independently selected from pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, -O-cyclopropyl, -O-cyclobutyl, and -O-cyclopentyl, and the pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, cyclopropyl, cyclobutyl, and cyclopentyl groups are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl, ethyl, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, and =O, more preferably R C1 These are, independently, -CF3, [ka] Selected from, more preferably, R C1 Each of them operates independently. [ka] Selected from, X1 is CR X1 Or selected from N, or X1 is NR X1 Selected from, X2 is CR X2 Or selected from N, X3 is CR X3 Or selected from N, X4 is CR X4 Or selected from N, R X1 , R X2 , R X3 , R X4 These are H, halogen, =O, CN, OH, COOH, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C 2-6 Alkynyl group, 5-12 membered heteroaryl group, -SO2-C 1-4 Alkyl alkyl, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, preferably R X1 , R X2 , R X3 , R X4 These are H, halogen, =O, CN, OH, COOH, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, C 2-6 Alkenyl group, C2-6 Alkynyl group, 5-12 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-12 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-4 Alkoxy group, -O-halo C 1-4 Alkyl alkyl group, C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, preferably R X1 , R X2 , R X3 , R X4 These are H, halogen, =O, CN, OH, COOH, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, 5-6 membered heteroaryl group, -SO2-C 1-2 Alkyl alkyl, -NR a CO-C 3-6 Cycloalkyl groups, 4-7 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-(4-7 member heterocycloalkyl), -C1-4 Alkyl-O-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bb Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-2 Alkoxy group, O-halo C 1-2 Alkyl alkyl group, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, preferably R X1 , R X2 , R X3 , R X4 These are H, halogen, =O, CN, OH, COOH, and C, respectively, independently. 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, C 2-4 Alkenyl group, C 2-4 Alkynyl group, 5-6 membered heteroaryl group, -NR a CO-C 3-6 Cycloalkyl groups, 4-7 member heterocycloalkyl groups, -OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-(5-6 member heteroaryl), -O-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-O-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-4 Alkyl-OC(=O)-(4-7 member heterocycloalkyl), -C 1-4 Alkyl-OC(=O)-NR aa -C 3-6 Cycloalkyl groups, -NR aa R bbSelected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, heterocycloalkyl group, and optionally further, halogen, OH, NH2, CN, C 1-2 Alkoxy group, -F, O-halo C 1-2 Alkyl alkyl group, C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, more preferably R X1 , R X2 , R X3 , R X4 These are, independently, H, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa The methyl group and ethyl group are selected from the above, and the methyl group and ethyl group are optionally further substituted with 1 to 4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, In some embodiments, R X1 , R X2 , R X3 , R X4 These are, independently, H, F, Cl, =O, CN, -SO2CH3, methyl group, ethyl group, and -NHCO-C. 3-6Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa Selected from, the methyl group, ethyl group, heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, and methoxy group. In some embodiments, R X1 , R X2 , R X3 , R X4 These are, independently, H, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHRaa Selected from, the methyl group, ethyl group, heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, and methoxy group. As one option, two arbitrarily selected Rs X1 , R X2 , R X3 , R X4 C 3-6 A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, NH2, CN, or C 1-4 Substituted with 1 to 4 groups selected from alkyl groups, In some embodiments, [ka] teeth, [ka] Selected from, In some embodiments, [ka] teeth, [ka] Selected from, R aa , R bb These are H, halogen, =O, and C, respectively, independently. 1-4 Alkyl alkyl group, C 1-4 Alkylhydroxy group, Halo C 1-4 Alkyl alkyl group, C 1-4 Alkoxy group or halo C 1-4 Selected from alkoxy groups.

[0021] Furthermore, the compounds described in Technical Proposal 11, their stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, RA These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa -SO2CH3, cyclopropyl group, cyclobutyl group, -NH-cyclopropyl, -NH-cyclobutyl, oxacyclopentyl group, [ka] -CF3, selected from 7-10 membered bicyclic heterocycloalkyl groups, the methyl group and ethyl group are optionally further substituted with 1-4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -C(=O)CH3, -O-CH3, and -O-CH2CH3. In some embodiments, R A These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C 1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa , cyclopropyl group, cyclobutyl group, -NH-cyclopropyl, -NH-cyclobutyl, 5-6 member heteroaryl group, [ka] -CF3, selected from 7-10 membered bicyclic heterocycloalkyl groups, the methyl group and ethyl group are optionally further substituted with 1-4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -C(=O)CH3, -O-CH3, and -O-CH2CH3. In some embodiments, R A These are, independently, F, Cl, =O, CN, methyl group, ethyl group, and -NHCO-C. 3-6 Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C 1-2 Alkyl-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-O-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC 3-6 Cycloalkyl groups, -C1-2 Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl), -C 1-2 Alkyl-OC(=O)-NH-C 3-6 Cycloalkyl groups, -NHR aa , cyclopropyl group, cyclobutyl group, -NH-cyclopropyl, -NH-cyclobutyl, 5-6 member heteroaryl group, [ka] The methyl group and ethyl group are selected from the above, and the methyl group and ethyl group are optionally further substituted with 1 to 4 groups selected from OH, NH2, CN, methyl group, ethyl group, and methoxy group, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, One option is two R's. A These, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group is optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group. R A1 These are, independently, F, Cl, =O, CN, OH, COOH, -SO2CH3, methyl group, ethyl group, and -OC. 3-6 Cycloalkyl groups, -NHR aa Selected from a 5-membered heteroaryl group and a 4-6 membered heterocycloalkyl group, the methyl group, ethyl group, cycloalkyl group, and 4-6 membered heterocycloalkyl group are optionally further substituted with 1 to 5 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, -CHF2, -CH2F, -CF3, and methoxy group, in some embodiments, R A1 These are, independently, F, Cl, =O, CN, OH, COOH, methyl group, ethyl group, and -OC. 3-6 Cycloalkyl groups, -NHR aaA 5-membered heteroaryl group is selected from a 4-6 membered heterocycloalkyl group, and the methyl group, ethyl group, cycloalkyl group, 5-membered heteroaryl group, and 4-6 membered heterocycloalkyl group are optionally further substituted with 1 to 5 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, and methoxy group. In some embodiments, R A1 These are, independently, F, Cl, =O, CN, OH, COOH, methyl group, ethyl group, and -OC. 3-6 Cycloalkyl groups, -NHR aa The methyl group, ethyl group, and cycloalkyl group are selected from the above, and the methyl group, ethyl group, and cycloalkyl group are optionally further substituted with 1 to 5 groups selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, and methoxy group. R B Each of these is independently selected from F, Cl, =O, methyl group, and ethyl group, and the methyl group and ethyl group are optionally further substituted with F and Cl groups, respectively. R C These are, independently, D, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCHF2, -OCH2F, -OCF3, 5-membered heteroaryl group, 6-membered heteroaryl group, -CN, =O, -NH-S(=O)2-C 1-2 Alkyl group, -O- (5-membered heteroaryl), -OC 3-6 Cycloalkyl groups, -O-(4-6 member monocyclic heterocycloalkyl groups), [ka] Selected from, the methyl group, ethyl group, heteroaryl group, and cycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, methyl group, ethyl group, -CHF2, -CH2F, and -CF3, in some embodiments, R CThese are, independently, D, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCHF2, -OCH2F, -OCF3, 5-membered heteroaryl group, 6-membered heteroaryl group, -CN, =O, -NH-S(=O)2-C 1-2 Alkyl group, -O- (5-membered heteroaryl), -OC 3-6 Cycloalkyl groups, -O-(4-6 member monocyclic heterocycloalkyl groups), [ka] The methyl group, ethyl group, heteroaryl group, and cycloalkyl group are selected from the above, and the methyl group, ethyl group, heteroaryl group, and cycloalkyl group are optionally further substituted with 1 to 4 groups selected from F, Cl, methyl group, ethyl group, and -CF3. In some embodiments, R C These are, independently, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCHF2, -OCH2F, -OCF3, 5-membered heteroaryl group, 6-membered heteroaryl group, -CN, =O, -NH-S(=O)2-C 1-2 Selected from alkyl groups, the methyl group, ethyl group, and heteroaryl group are optionally substituted with 1 to 4 groups further selected from F, Cl, methyl group, and ethyl group. R C1 These are, independently, F, Cl, methyl group, ethyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, and C. 4-5 Cycloalkyl groups, cubanes, 5-membered heteroaryl groups, 6-membered heteroaryl groups, 8-membered fused heteroaryl groups, 9-membered fused heteroaryl groups, 10-membered fused heteroaryl groups, 7-8 membered spirocyclic heterocycloalkyl groups, 8-9 membered fused heterocycloalkyl groups, 7-membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R aa R bb ,-P(=O)R aa R bb , -NR a S(=O)2C1-4 Alkyl alkyl, -NR a P(=O)(C 1-4 Alkyl)2, -NR a S(=O)2NR aa R bb , -NR a C(=O)-C 3-6 Cycloalkyl groups, -C(=O)NR a -C 3-6 Cycloalkyl groups, -OC 3-6 Cycloalkyl groups, -O-(4-6 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NH-C 3-6 Cycloalkyl groups, -NH-(4-6 member heterocycloalkyl groups), -NH-(5-6 member heteroaryl groups), -NH-S(=O)2-C 3-6 Cycloalkyl groups, -C 1-2 Alkyl-(5-membered heteroaryl), -C 1-2 Alkyl-(6-membered heteroaryl), -C 1-2 Alkylphenyl, -C 1-2 Alkyl-(4-6 member heterocycloalkyl), -NR a C(=O)-OR a ,-(C 1-2 Alkyl) n -O-(C 1-2 Alkyl) n -(4-6 member heterocyclyl), -NR a C(=O)-(4-6 member heterocyclyl), -C(=O)NR a -(4-6 member heterocycline), [ka] -C(=O)-C 3-6 The alkyl group, cycloalkyl group, heterocyclyl group, heteroaryl group, heterocycloalkyl group, and cubane are optionally further selected from F, Cl, OH, NH2, CN, methyl group, ethyl group, deuterated methyl group, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, =O, and -C(=O)C 1-4Alkyl group, -NH-C(=O)C 1-4 Alkyl group, -S(=O)2C 1-2 Substituted with 1 to 4 groups selected from alkyl groups, R a The group is selected from H, F, Cl, methyl group, ethyl group, cyclopropyl group, cyclobutyl group, cyclopentyl group, and difluorocyclobutyl group. R aa , R bb Each of these is independently selected from H, F, Cl, =O, methyl group, ethyl group, -CH2-CH2-OH, -CH2-OH, -CHF2, -CH2F, -CF3, -CH2CF3, -CH2CHF2, -CH2CH2F, -OCH3, -OCH2CH3, -OCHF2, -OCH2F, -OCF3, -OCH2CF3, -OCH2CHF2, -OCH2CH2F, As one option, R aa , R bb These, together with the carbon atoms bonded to them, form a 4-6 membered heterocyclyl group, and the heterocyclyl group is optionally further substituted with 1-4 groups selected from F, Cl, OH, NH2, CN, methyl group, and ethyl group, and n1 is selected from 0, 1, 2, or 3. n2 is selected from 0 or 1. n3 is selected from 0, 1, 2, 3, or 4. In some embodiments, n3 is selected from 0, 1, or 2. L1 is a bond, vinylidene group, -CH2-, -CH2-CH2-, 4-6 member monocyclic heterocycloalkyl group, (4-6 member monocyclic heterocycloalkyl group)-C(=O)-CH2-, -(4-6 member monocyclic heterocycloalkyl group)-CH2-, -CH2-(4-6 member monocyclic heterocycloalkyl group)-, -CH(CH3)NHC(=O)-CH2-, -CH2NHC(=O)-CH2-, -S(=O)2-CH2-, -C(=S)-CH2-, -C(=O)-C 3-6 Cycloalkyl groups, -C(=O)-CH(CH3)-, -C(=O)-CH(C 3-6 Cycloalkyl)-, -C(=O)-CF2-, -C(=O)-C(CH3)2-, -CH2-C(=O)-, -C(=O)-C(=O)-, C3-6 Cycloalkyl group, -(5-6 member heteroaryl)-CH2-, 5-6 member heteroaryl group, -C(=O)-, -C(=O)-CH2-, -N(CH3)-CH2-, -CF2-CH2-, -C(=O)-C 2-4 The group is selected from alkenylene, -C(=O)-O-, -C(=O)-NH-, and -C(=O)-N(CH3)-, and the -CH2-, alkenylene, cycloalkyl, heterocycloalkyl, and heteroaryl groups may optionally be further selected from 1 to 3 R groups. L1 Replaced with R L1 Each of these is independently selected from F, Cl, Br, =O, methyl group, ethyl group, -CF3, -CHF2, -CH2F, vinyl group, propenyl group, methoxy group, ethoxy group, -OCF3, -OCHF2, -OCH2F, cyclopropyl group, cyclobutyl group, methyl-methoxy, and 5-membered heteroaryl group. One option is L1, [ka] Selected from, [ka] The terminal end is connected to ring B, L2 is selected from a bond, vinylidene group, ethynylene group, -CH2-, -CH2-CH2-, -O-, -NH-, -C(=O)-, and -N(CH3)-.

[0022] Furthermore, the compound described in Technical Proposal 12, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, having the structure of formula (II), [ka] Ring A may optionally have one, two, or three additional R rings. A The following structure will be replaced by: [ka] Select from, or [ka] Selected from, het is a 5-membered heteroaryl group, and the heteroaryl group can optionally be a halogen, C 1-2 Alkyl, halo C 1-2 Alkyl groups, deuterated C 1-2 Substituted with one or two groups selected from alkyl groups, Each R A These are, independently, halogen, CN, and C. 1-4 Alkyl alkyl group, C 1-4 Alkoxy group, Halo C 1-4 alkyl group, -OC 3-6 Cycloalkyl groups, 4-6 member heterocycloalkyl groups, 5-6 member heteroaryl groups, -SO2-C 1-2 Selected from alkyl groups, the heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further a halogen, OH, NH2, CN, or C 1-2 Alkyl alkyl group, C 1-2 Alkoxy group, -C(=O)C 1-2 Alkyl, halo C 1-2 Substituted with 1-2 groups selected from alkyl groups, The C ring is [ka] The C ring is selected from, and the C ring may optionally have an additional 1, 2, or 3 R rings. C Replaced by, Each R C These are, independently, halogen and halo C. 1-3 Alkyl, halo C 1-4 Alkoxy group, C 3-5 Cycloalkyl group, 5-6 membered heteroaryl group, -OC 3-6 Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -OC 5-8 Spirocycloalkyl groups, [ka] Selected from the heteroaryl group, cycloalkyl group, and spirocycloalkyl group, the heteroaryl group, cycloalkyl group, and optionally further, halogen, C 1-2 Alkyl, halo C 1-2 Alkyl groups, deuterated C 1-2 It is substituted with 1 to 3 groups selected from alkyl groups.

[0023] Furthermore, the compounds described in Technical Proposal 13, their stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, Ring A is [ka] Selected from, Each R C Each of them operates independently. [ka] F, Cl, CF3, CHF2, CH2F, -OCHF2, -OCH2F, -OCF3, -OCH2CF3, -OCH(CH3)CF3, cyclopropyl group, cyclobutyl group, [ka] Selected from.

[0024] As a specific technical example of the present invention, a compound described in the present invention, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt thereof, wherein the compound is selected from one of the structures in Table A below.

[0025] [Table 1-1] [Table 1-2] [Table 1-3] [Table 1-4] Table 1-5 Table 1-6 Table 1-7 Table 1-8 Table 1-9 Table 1-10 Table 1-11 Table 1-12 Table 1-13 Table 1-14 Table 1-15 Table 1-16 Table 1-17 Table 1-18 Table 1-19 Table 1-20

[0026] The present invention further provides a pharmaceutical composition or pharmaceutical preparation comprising a compound described in any one of the above-mentioned technical proposals, its stereoisomer, deuteride, solvate, cocrystal or pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier and / or excipient.

[0027] Furthermore, the present invention provides a composition or pharmaceutical preparation comprising 1 to 1500 mg of any one of the aforementioned technical proposals, its stereoisomer, deuteride, solvate, cocrystal or pharmaceutically acceptable salt and carrier and / or excipient.

[0028] The present invention further provides applications for the manufacture of drugs for treating / preventing CHRM4-mediated diseases, including, but more specifically, the compounds described in any one of the aforementioned technical proposals, their stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts, or compositions described in any one of the aforementioned technical proposals. The CHRM4-mediated diseases include Alzheimer's disease, schizophrenia or psychosis, pain, addiction, sleep disorders, cognitive impairment, Parkinson's disease, and Parkinson's disease-levodopa-induced dyskinesia. The following conditions are selected from Huntington's disease, motor disorders, dry mouth, pulmonary hypertension, chronic obstructive pulmonary disease, asthma, urinary incontinence, glaucoma, trisomy 21, cerebral amyloid angiopathy, dementia, Dutch-type hereditary amyloidosis, prion disease, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, pancreatitis, inclusion body myositis, other peripheral amyloidosis, diabetes mellitus, autism, and atherosclerosis, and are preferably Alzheimer's disease, schizophrenia, pain, addiction, and sleep disorders.

[0029] The present invention further provides a method for treating a mammalian or human disease, the method comprising administering to a subject a therapeutically effective amount of any one of the aforementioned technical proposals or its stereoisomer, deuteride, solvate, or pharmaceutically acceptable salt thereof, the therapeutically effective amount being preferably 1 to 1500 mg, the disease being Alzheimer's disease, schizophrenia or psychosis, pain, addiction, sleep disorders, cognitive impairment, Parkinson's disease, Parkinson's disease-levodopa-induced dyskinesia, ha The conditions are selected from Antington's disease, motor disorders, dry mouth, pulmonary hypertension, chronic obstructive pulmonary disease, asthma, urinary incontinence, glaucoma, trisomy 21, cerebral amyloid angiopathy, dementia, Dutch-type hereditary amyloidosis, prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, pancreatitis, inclusion body myositis, other peripheral amyloidosis, diabetes mellitus, autism, and atherosclerosis, wherein the conditions are preferably Alzheimer's disease, schizophrenia, pain, addiction, and sleep disorders. In some embodiments, the mammals described in the present invention do not include humans.

[0030] The “effective dose” or “therapeutic effective dose” as described in this application comprises administering a sufficient amount of the compound disclosed herein that alleviates, to some extent, one or more symptoms of the disease or condition being treated. In some embodiments, the result is a reduction and / or alleviation of the signs, symptoms or causes of the disease, or any other desirable change in the biological system. For example, the “effective dose” for therapeutic use is the amount of a composition containing the compound disclosed herein that is necessary to provide a clinically significant reduction in disease symptoms. Examples of therapeutically effective doses include 1-1500mg, 1-1400mg, 1-1300mg, 1-1200mg, 1-1000mg, 1-900mg, 1-800mg, 1-700mg, 1-600mg, 1-500mg, 1-400mg, 1-300mg, 1-250mg, 1-200mg, 1-150mg, 1-125mg, 1-100mg, 1-80mg, 1-60mg, 1-50mg, 1-40mg, 1-25mg, 1-20mg, and 5-1 500mg, 5~1000mg, 5~900mg, 5~800mg, 5~700mg, 5~600mg, 5~500mg, 5~400mg, 5~300mg, 5~250mg, 5~200mg, 5~150mg, 5~1 25mg, 5~100mg, 5~90mg, 5~70mg, 5~80mg, 5~60mg, 5~50mg, 5~40mg, 5~30mg, 5~25mg, 5~20mg, 10~1500mg, 10~1000mg, 10 ~900mg, 10~800mg, 10~700mg, 10~600mg, 10~500mg, 10~450mg, 10~400mg, 10~300mg, 10~250mg, 10~200mg, 10~150mg, 1 0~125mg, 10~100mg, 10~90mg, 10~80mg, 10~70mg, 10~60mg, 10~50mg, 10~40mg, 10~30mg, 10~20mg, 20~1500mg, 20~1000 mg, 20~900mg, 20~800mg, 20~700mg, 20~600mg, 20~500mg, 20~400mg, 20~350mg, 20~300mg, 20~250mg, 20~200mg, 20~15 0mg, 20~125mg, 20~100mg, 20~90mg, 20~80mg, 20~70mg, 20~60mg, 20~50mg, 20~40mg, 20~30mg, 50~1500mg, 50~1000mg,This includes, but is not limited to, the following dosage ranges: 50-900mg, 50-800mg, 50-700mg, 50-600mg, 50-500mg, 50-400mg, 50-300mg, 50-250mg, 50-200mg, 50-150mg, 50-125mg, 50-100mg, 100-1500mg, 100-1000mg, 100-900mg, 100-800mg, 100-700mg, 100-600mg, 100-500mg, 100-400mg, 100-300mg, 100-250mg, and 100-200mg.

[0031] The present invention relates to a kit, which may comprise a single-dose or multiple-dose composition comprising the compound of the present invention or its stereoisomer, deuteride, or pharmaceutically acceptable salt, wherein the amount of the compound of the present invention or its stereoisomer, deuteride, or pharmaceutically acceptable salt is the same as the amount in the pharmaceutical composition.

[0032] In the present invention, the amount of the compound of the present invention, its stereoisomer, or a pharmaceutically acceptable salt is, in each case, calculated in terms of the form of the free base.

[0033] "Formulation specifications" refer to the weight of the active ingredient contained in one unit formulation, one tablet formulation, or any other unit formulation.

[0034] Synthesis pathway Methods for producing CHRM4 receptor agonists are described in patent documents such as WO2018002760A1, and those skilled in the art can produce the compounds of the present invention by combining said documents with known organic synthesis techniques, the starting materials being commercially available chemicals and / or compounds described in chemical literature. "Commercially available chemicals" are obtained from legitimate commercial sources, including companies such as Taitan Technology, Annaij Chemical, Shanghai Demo, Chengdu Kelong Chemical, Shaoyuan Chemical Technology, Nanjing Yaoshi, Wuxing Kangde and Bailingwei Technology.

[0035] Indexes of known chemical substances, compiled by the American Chemical Society's chemical information retrieval service, allow for the selective identification of specific and similar reactants. These indexes are available in many public and university libraries and online. For known chemicals that are not commercially available in catalogs, it is optional to commission a custom chemical synthesizer to produce them, and many standard chemical suppliers offer custom synthesis services.

[0036] term Unless otherwise specified in this invention, the terms used in this invention have the following meanings.

[0037] Unless otherwise specified in this invention, the terms used in this invention have the following meanings.

[0038] The carbon, hydrogen, oxygen, sulfur, nitrogen, or halogens in the groups and compounds described in the present invention all include their isotopes, and the carbon, hydrogen, oxygen, sulfur, nitrogen, or halogens in the groups and compounds described in the present invention may be optionally further substituted with one or more corresponding isotopes, where the isotope of carbon is, 12 C and, 13 C and, 14 It contains C, and its isotopes include protium (H), deuterium (D, also called heavy hydrogen), and tritium (T, also called tritium), and its isotopes include 16 O and, 17 O and, 18 It contains O, and the sulfur isotopes are 32 S and, 33 S and, 34 S and, 36 It contains S, and the isotopes of nitrogen are 14 N and 15 It contains N, and the isotopes of fluorine are 19 It is F, and the isotope of chlorine is, 35 Cl and 37 It contains Cl, and the isotope of bromine is, 79 Br and 81 Includes Br.

[0039] In this specification, "halogen" refers to F, Cl, Br, I, or their isotopes.

[0040] "Halogenation" or "halogen substitution" means that a hydrogen atom is substituted with one or more of the following selected from F, Cl, Br, I, or their isotopes, the upper limit of the number of halogen substituents is equal to the sum of the substitutable hydrogens of the group being substituted, and unless otherwise specified, the number of halogen substituents is any integer between 1 and the upper limit, and if the number of halogen substituents is greater than 1, they may be substituted with the same or different halogens.

[0041] "Deuterated" or "deuterated product" refers to a situation in which a hydrogen atom in a group such as an alkyl group, cycloalkyl group, alkylene group, aryl group, heteroaryl group, mercapto group, heterocycloalkyl group, alkenyl group, or alkynyl group is substituted with at least one isotopic hydrogen atom. The upper limit of the number of deuterated groups is equal to the sum of the number of substituted hydrogen atoms in the group being substituted. Unless otherwise specified, the number of deuterated groups is any integer between 1 and the upper limit, preferably 1 to 20 deuterium atom substitutions, more preferably 1 to 10 deuterium atom substitutions, even more preferably 1 to 6 deuterium atom substitutions, and even more preferably 1 to 3 deuterium atom substitutions.

[0042] "Alkyl group" refers to a monovalent linear or branched saturated aliphatic hydrocarbon group, which unless otherwise specified, is an alkyl group with 1 to 20 carbon atoms, preferably an alkyl group with 1 to 8 carbon atoms, more preferably an alkyl group with 1 to 6 carbon atoms, even more preferably an alkyl group with 1 to 4 carbon atoms, and even more preferably an alkyl group with 1 to 2 carbon atoms. Non-limiting examples include methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, sec-butyl group, neobutyl group, tert-butyl group, n-pentyl group, isopentyl group, neopentyl group, n-hexyl group and various branched isomers thereof.

[0043] "Alkylene group" refers to a divalent linear and branched saturated alkyl group. Examples of alkylene groups include, but are not limited to, methylene, ethylene, propylene, and butylene groups.

[0044] "Cycloalkyl group" refers to a monovalent, non-aromatic, partially unsaturated or fully saturated, substituted or unsubstituted carbocyclic hydrocarbon group, which, unless otherwise specified, typically has 3 to 12 carbon atoms, preferably 3 to 10 carbon atoms, more preferably 3 to 6 carbon atoms, and even more preferably 3 to 4 carbon atoms. Non-limiting examples include cyclopropyl group, cyclobutyl group, cyclopentyl group, cyclohexyl group, [ka] or containing cycloheptyl, etc.

[0045] A "cycloalkylene group" is a divalent group of a "cycloalkyl group," and non-limiting examples include cyclopropylene groups, cyclobutylene groups, and the like.

[0046] A "heterocyclic ring" or "heterocyclyl group" refers to a substituted or unsubstituted, saturated or unsaturated, aromatic or non-aromatic ring, which, unless otherwise specified, contains 1 to 3 heteroatoms selected from N, O, or S, and includes monocyclic heterocycles, bridging bicyclic heterocycles, fused bicyclic heterocycles, spiro-dicyclic heterocycles, fused tricyclic heterocycles, etc., and unless otherwise specified, is a 3 to 14-membered heterocycle, more preferably a 4 to 12-membered heterocycle, more preferably a 4 to 10-membered heterocycle, and even more preferably a 4 to 7-membered heterocycle. Its definition includes heterocycloalkyl groups and heteroaryl groups. The N and S in the heterocyclic group can be oxidized to various oxidation states. The heterocyclo group may be linked to a heteroatom or carbon atom, and non-limiting examples include oxyranyl group, azacyclopropyl group, oxetanyl group, azetidinyl group, 1,3-dioxolanyl group, 1,4-dioxolanyl group, 1,3-dioxanyl group, azacycloheptyl group, pyridyl group, furyl group, thienyl group, pyranyl group, N-alkylpyrryl group, pyrimidinyl group, pyrazinyl group, pyrazolyl group, pyridadinyl group, imidazolyl group, piperidinyl group, piperidinyl group, morpholino group, thiomorpholino group, 1,3-dithianyl group, dihydrofuryl group. L group, dihydropyranyl group, dithiolanyl group, tetrahydrofuranyl group, tetrahydropyrrolyl group, tetrahydroimidazolyl group, oxazolyl group, dihydrooxazolyl group, tetrahydrooxazolyl group, tetrahydrothiazolyl group, tetrahydropyranyl group, benzimidazolyl group, benzopyridyl group, pyrrolopyridyl group, benzodihydrofuryl group, azabicyclo[3.2.1]octyl group, azabicyclo[5.2.0]nonyl group, oxatricyclo[5.3.1.1]dodecyl group, azaadamantyl group and oxapiro[3.3]heptyl group, [ka] This includes, among others.

[0047] A "heterocyclylene group" is a divalent group corresponding to a "heterocyclic group," and non-limiting examples include imidazolyl groups, piperidinylene groups, and aziridinyl groups.

[0048] "Carbon ring" or "carbon ring group" refers to a substituted or unsubstituted, saturated or unsaturated, aromatic or non-aromatic carbon ring group, including monocyclic carbon rings, bicyclic bridged rings, bicyclic parallel rings, and bicyclic spiro rings, and unless otherwise specified, has 3 to 12 carbon atoms, preferably 3 to 10 carbon atoms, and more preferably 3 to 6 carbon atoms. Its definition includes cycloalkyl groups and aryl groups. In non-limiting examples, monocyclic carbon rings include cyclopropyl groups, cyclobutyl groups, cyclopentyl groups, cyclohexyl groups, cycloheptyl groups, or phenyl groups. [ka] The double-ring bridge includes, [ka] Including such as, a biring parallel ring is, [ka] The biring spiro ring includes, [ka] This includes, among others.

[0049] An "aryl group" refers to an aromatic carbon ring. Non-limiting examples include phenyl groups, naphthyl groups, and the like.

[0050] An "alkynyl group" refers to a linear or branched monounsaturated hydrocarbon group containing one or more carbon-carbon triple bonds. Unless otherwise specified, an alkynyl group contains 2 to 6 carbon atoms, preferably 2 to 4 carbon atoms. Non-limiting examples include ethynyl, propynyl, and propargyl groups.

[0051] An "alkenyl group" refers to a linear or branched monounsaturated hydrocarbon group containing one or more carbon-carbon double bonds. Unless otherwise specified, an alkenyl group contains 2 to 6 carbon atoms, preferably 2 to 4 carbon atoms. Non-limiting examples include vinyl groups, propenyl groups, allyl groups, 2-butenyl groups, and 1-butenyl groups.

[0052] "Alkoxy group" or "alkyloxy group" refers to an -O-alkyl group, and unless otherwise specified, -OC 1-8 It is an alkyl group, preferably -OC 1-6 It is an alkyl group, more preferably -OC 1-4 It is an alkyl group, and more preferably -OC 1-2 It is an alkyl group. Non-limiting examples include methoxy group, ethoxy group, n-propoxy group, isopropoxy group, n-butoxy group, sec-butoxy group, tert-butoxy group, n-pentyloxy group, n-hexyloxy group, cyclopropoxy group and cyclobutoxy group, etc. "Haloalkoxy group" refers to -O-haloalkyl groups, and unless otherwise specified, -O-haloC 1-8 It is an alkyl group, preferably -O-haloC 1-6 It is an alkyl group, more preferably -O-haloC 1-4 It is an alkyl group, and more preferably -O-haloC 1-2 It is an alkyl group. Non-restrictive examples include monofluoromethoxy groups, difluoromethoxy groups, trifluoromethoxy groups, difluoroethyloxy groups, etc.

[0053] "C 1-4 The alkylacyl group is C 1-4 This refers to alkyl-C(O)-. Non-limiting examples include formyl groups, acetyl groups, and propionyl groups.

[0054] "C 1-4 The alkylsulfonyl group is C 1-4 This refers to alkyl-S(O)2-. Non-limiting examples include methanesulfonyl groups, ethylsulfonyl groups, and propylsulfonyl groups.

[0055] A "heteroaryl ring" or "heteroaryl group" refers to an aromatic heterocyclic ring. Non-limiting examples include pyrazolyl, pyrimidinyl, thiazolyl, pyridyl, furyl, pyranone, and pyridone.

[0056] A "heterocycloalkyl group" refers to a partially or completely unsaturated non-aromatic heterocycle which generally has 4 to 12 ring members, preferably 4 to 10 ring members, more preferably 4 to 7 ring members, and even more preferably 5 or 6 ring members. In addition to carbon atoms, a heterocycloalkyl group further comprises 1 to 3 heteroatoms selected from N, S, and O as ring members. Non-limiting examples include azetidinyl groups, morpholino groups, piperazinyl groups, piperidinyl groups, tetrahydropyranyl groups, oxetanyl groups, and the like.

[0057] "Optionally" or "optionally" means that the event or environment described thereafter may occur, but does not necessarily occur, and the description includes both cases where the event or environment occurs and cases where it does not. For example, "an alkyl group that is optionally substituted with F" means that the alkyl group may be substituted with F, but does not necessarily have to be substituted with F, and indicates that this includes cases where the alkyl group is substituted with F and cases where the alkyl group is not substituted with F.

[0058] If any specific structure or fragment listed in this invention is further substituted, the hydrogen atoms shown in the specific structure may also be optionally substituted, for example, in general formulas such as general formula structures (I) and (II), the A ring may optionally have an additional 1, 2, or 3 R atoms. A Replaced by [ka] Selected from, [ka] In a structure containing the nitrogen atom, the hydrogen atom on the nitrogen is still R A It can be replaced with.

[0059] "Pharmacologically acceptable salt" refers to a salt obtained by a reaction in which the compound of the present invention maintains the biological efficacy and properties of the free acid or free base, and by a reaction in which the free acid is reacted with a non-toxic inorganic base or organic base, or with a non-toxic inorganic acid or organic acid.

[0060] "Pharmaceutical composition" means one or more of the compounds herein or their stereoisomers, solvates, pharmaceutically acceptable salts or cocrystals, or mixtures with other components, wherein the other components include physiologically / pharmaceutically acceptable carriers and / or excipients.

[0061] A "carrier" refers to a system that does not cause significant irritation to the living body, does not cause the loss of the biological activity and properties of the administered compound, alters the method of drug administration to the human body and its distribution within the body, controls the rate of drug release, and delivers the drug to the target organ. Non-limited examples include microcapsules and microspheres, nanoparticles, and liposomes.

[0062] "Excipients" are substances that are not therapeutic agents themselves, but are added to pharmaceutical compositions as diluents, excipients, adhesives and / or mediators to improve their treatment and preservation properties, or to allow or facilitate the formation of a dosage form for administration. As is known to those skilled in the art, medicinal excipients can provide a variety of functions and may be described as wetting agents, buffers, suspension aids, lubricants, emulsifiers, disintegrants, absorbents, preservatives, surfactants, colorants, flavoring agents and sweeteners. Examples of medicinal excipients include: (1) sugars, e.g., lactose, glucose, and sucrose; (2) starches, e.g., corn starch and potato starch; (3) cellulose and its derivatives, e.g., sodium carboxymethylcellulose, ethylcellulose, cellulose acetate, hydroxypropylmethylcellulose, hydroxypropylcellulose, microcrystalline cellulose, and cross-linked carboxymethylcellulose (e.g., sodium cross-linked carboxymethylcellulose); (4) tragacanth gum powder; (5) malt; (6) gelatin; (7) talc; (8) excipients, e.g., cocoa (9) Fat, suppository wax, (10) Oils, such as peanut oil, cottonseed oil, safflower oil, goa oil, olive oil, corn oil and soybean oil, (11) Glycols, such as propylene glycol, (12) Polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol, (13) Esters, such as ethyl oleate and ethyl laurate, (14) Agar, (15) Buffers, such as magnesium hydroxide and aluminum hydroxide, (16) Alginic acid, (17) Water for endotoxin testing, (18) Isotonic saline solution, (19) Ringer's solution, (20) Ethanol, (21) pH buffer solution, (22) Polyesters, polycarbonates and / or polyanhydrides, and (23) Other non-toxic and suitable substances used in pharmaceutical formulations, but not limited to these.

[0063] "Stereoisomers" refer to isomers that arise from different arrangements of atoms in a molecule, and include cis-trans isomers, enantiomers, and conformational isomers.

[0064] The compounds of the present invention may have a specific geometry or stereoisomer configuration. In the present invention, all such compounds include cis and trans isomers, (-)- and (+)-enantiomers, (R)- and (S)-enantiomers, diastereomers, (D)-isomers, (L)-isomers, and racemic and other mixtures thereof, such as enantiomer or diastereomer-rich mixtures, all of which fall within the scope of the present invention. Other chiral carbon atoms may be present as substituents on the compounds of the present invention. All of these isomers and mixtures thereof are within the scope of the present invention. In some embodiments, preferred compounds are isomer compounds that exhibit superior biological activity. Purified or partially purified isomers and stereoisomers, or racemic or diastereomer mixtures of the compounds of the present invention are also within the scope of the present invention. Purification and separation of such substances can be achieved by standard techniques known in the art.

[0065] A "solvate" refers to a substance formed when the compound or salt thereof of the present invention forms intermolecular non-covalent bonds with a stoichiometric or non-stoichiometric solvent. When the solvent is water, it becomes a hydrate.

[0066] A "cocrystal" refers to a crystalline body formed when an active pharmaceutical ingredient (API) and a cocrystal compound (CCF) are bonded together by hydrogen bonds or other non-covalent bonds, where the pure states of the API and CCF are both solids at room temperature, and a fixed stoichiometric ratio exists between each component. Cocrystals are multi-component crystalline bodies, including not only binary cocrystals formed between two neutral solids, but also multi-component cocrystals formed between a neutral solid and a salt or solvate. [Modes for carrying out the invention]

[0067] The present invention will be described in detail below with reference to examples. Unless specific conditions are specified in the examples, the experiments were carried out according to general experimental conditions. The examples given are for the purpose of better illustrating the present invention, and it should be understood that the present invention is not limited to the examples given. Non-essential improvements and adjustments made by those skilled in the art to the embodiments based on the above invention are still within the scope of protection of the present invention.

[0068] Test method The structure of the compound was determined by nuclear magnetic resonance (NMR) and / or mass spectrometry (MS). NMR displacement (δ) was given in units of 10⁻⁶ (ppm). NMR measurements were performed using a nuclear magnetometer (Bruker Avance III 400 and Bruker Avance 300), with deuterated dimethyl sulfoxide (DMSO-d6), deuterated chloroform (CDCl3), and deuterated methanol (CD3OD) as the measurement solvents, and tetramethylsilane (TMS) as the internal standard. MS measurements were performed using (Agilent 6120B (ESI) and Agilent 6120B (APCI)). HPLC measurements were performed using an Agilent 1260DAD high-pressure liquid chromatograph (Zorbax SB-C18 100×4.6mm, 3.5μM). For thin-layer chromatography, silica gel plates such as Yantai Huanghai HSGF254 or Qingdao GF254 are used. The silica gel plate size used for thin-layer chromatography (TLC) is 0.15mm to 0.20mm, while the size used for product separation and purification by chromatography is 0.4mm to 0.5mm. Column chromatography typically uses silica gel of 200-300 mesh size from Yantai Huanghai as the support material. Example 1: [ka]

[0069] Step 1: Compound 1A (1.4g, 9.44 mmol), 3-thiopheneboronic acid (1.81g, 14.16 mmol), and tetrakistriphenylphosphine palladium (0.55g, 0.47 mmol) were sequentially dissolved in a toluene / ethanol (24 mL / 6 mL) mixture, the mixture was bubbling with nitrogen gas for 5 minutes, 10 mL of 2 M potassium carbonate solution was added, the mixture was bubbling with nitrogen gas for another 5 minutes, and the temperature was raised to 90°C under a nitrogen atmosphere and the reaction was allowed to proceed overnight. The reaction mixture was cooled to room temperature, ethyl acetate (30 mL x 2) was added for extraction, the combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain the crude product. The crude product was purified using Biotage Isolera One (20 g silica gel column, eluent: 0-30% ethyl acetate / petroleum ether) to obtain compound 1B (1.50 g, 81.21%). LC-MS(ESI): m / z = 196.1[M+H] + .

[0070] Step 2: Compound 1C (1.0 g, 4.11 mmol) was dissolved in dichloromethane (10 mL), and trifluoroacetic acid (4.0 mL) was added dropwise. After the addition was complete, the mixture was allowed to react overnight at room temperature. The reaction mixture was concentrated to obtain the crude compound 1D, which was used directly in the next step. LC-MS(ESI): m / z = 144.1[M+H] + .

[0071] Step 3: Compound 1B (0.5g, 2.56 mmol) was dissolved in dimethyl sulfoxide (10 mL), and the crude compound 1D obtained in Step 2, DIPEA (0.99 g, 7.66 mmol), and cesium fluoride (0.39 g, 2.56 mmol) were added sequentially. After all additions were made, the temperature was raised to 100°C and the mixture was reacted overnight. After the reaction was complete, the temperature was lowered to room temperature, water (30 mL) was added, and the mixture was extracted with ethyl acetate (30 mL x 2). The combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain the crude product. The crude product was purified using Biotage Isolera One (20 g silica gel column, eluent: 0-50% ethyl acetate / petroleum ether) to obtain compound 1E (0.31 g, 40.05%). LC-MS(ESI): m / z = 303.1[M+H] + .

[0072] Step 4: Compound 1E (0.3g, 0.99 mmol) was dissolved in tetrahydrofuran (3 mL), and lithium hydroxide monohydrate (0.083g, 1.98 mmol) and water (3 mL) were added sequentially. The mixture was stirred overnight at room temperature. After the reaction was complete, 5% potassium bisulfate solution was added dropwise to adjust the pH to 5-6, the mixture was concentrated to remove the solvent, tetrahydrofuran (5 mL) was added, the mixture was stirred homogenously, and the mixture was concentrated again until dry. The mixture was then stirred with methanol (10 mL), filtered, the filter cake was washed with methanol (5 mL x 2), the filtrates were combined, and the mixture was concentrated until dry to obtain compound 1F (0.19g, 69.96%). LC-MS(ESI): m / z = 275.1[M+H] + .

[0073] Step 5: Compound 1F (150 mg, 0.55 mmol), 2,4-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-B]pyridine dihydrochloride (intermediate 1) (0.15 g, 0.83 mmol), and DIPEA (0.36 g, 2.78 mmol) were sequentially added to pyridine (10 mL), the mixture was cooled to 0°C, and T3P (1.04 g, 50% in EA, 1.63 mmol) was added dropwise. After the addition was complete, the mixture was allowed to rise naturally and reacted overnight. The solution was concentrated, and ethyl acetate (30 mL) was added to the residue. After stirring and dilution, 10% potassium carbonate aqueous solution (30 mL) was added, stirred for 10 minutes, allowed to stand, and liquid-liquid was separated. The separated organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, concentrated to obtain the crude product, and purified using Biotage Isolera One (20 g silica gel column, eluent: 0-50% ethyl acetate / petroleum ether) to obtain compound 1 (85 mg, 38.20%). LC-MS(ESI): m / z = 405.4[M+H] + . 1 H NMR (400MHz,CDCl3) δ 8.25 (d,1H),7.87 (s,1H),7.58 (d,1H),7.36 (dd,1H),6.91(d,1H),6.56(s,1H),6.20-6.18 (m,1H),4.79-4.73 (m,4H),4.30-4.25 (m,2H),3.77-3.72 (m,2H),3.33-3.28 (m,1H),2.82 (t,2H),2.52 (d,3H),2.27 (d,3H). Example 2: [ka]

[0074] Step 1: 2A (0.35 g, 1.62 mmol), intermediate 1 (0.2 g, 1.35 mmol), N-methylimidazole (0.23 g, 2.76 mmol), and TEA (0.0.41 g, 4.05 mmol) were sequentially dissolved in DCM (10 mL), stirred at room temperature for 30 minutes, and then TCFH (0.45 g, 1.61 mmol) was added and the reaction was continued at room temperature for 2 hours. The reaction mixture was poured into water and extracted three times with ethyl acetate. The combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the crude product. The crude product was purified using a Biotage Isolera One medium-pressure preparative apparatus (12 g silica gel column, eluent: 0-5% MeOH / DCM) to obtain the target compound 2B (0.25 g, yield 53.61%). LC-MS(ESI): m / z = 346.2[M+H] + .

[0075] Step 2: 2B (0.25 g, 0.69 mmol) was dissolved in DCM (10 mL), then TFA (3 mL) was added, and the mixture was reacted at room temperature for 2 hours. After the reaction was complete, the mixture was concentrated, the residue was dissolved in ethyl acetate, and saturated sodium bicarbonate aqueous solution was added dropwise to adjust the pH to basic. The mixture was extracted, the aqueous phase was extracted twice with ethyl acetate, the combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain 2C (0.13 g, yield 76.80%). LC-MS(ESI): m / z = 246.2[M+H] + .

[0076] Step 3: 2C (0.13g, 0.53 mmol), 2D (0.15g, 0.8 mmol), and N-methylimidazole (0.13g, 1.59 mmol) were sequentially dissolved in DCM (10 mL), stirred at room temperature for 30 minutes, then TCFH (0.18g, 0.64 mmol) was added, and the reaction was continued at room temperature for 2 hours. After the reaction was complete, the reaction mixture was poured into water and extracted three times with ethyl acetate. The combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the crude product. The crude product was purified using a Biotage Isolera One medium-pressure preparative apparatus (12 g silica gel column, eluent: 0-5% MeOH / DCM) to obtain target compound 2 (0.08 g, yield 36.08%).

[0077] LC-MS(ESI): m / z = 419.1[M+H] + . 1 H NMR (400MHz,Chloroform-d) δ 8.85-8.79 (m,1H),7.93-7.86 m,1H),7.72-7.65 (m,1H),6.94-6.88 (m,1H),4.78-4.68 (m,4H),4.67-4.55 (m,1H),4.51-4.38 (m,1H),4.14-4.06 (m,1H),4.03-3.94 (m,1H),3.33-3.17 (m,1H),2.86-2.67 (m,2H),2.55-5.50 (m,3H),2.28-2.23 (m,3H). Example 3: [ka]

[0078] Step 1: Compound 3A (10.0 g, 47.85 mmol) was dissolved in toluene (100 mL), and p-toluenesulfonic acid (1.6 g, 9.57 mmol) and ethanedithiol (5.4 g, 57.42 mmol) were added. The mixture was reacted at 130 °C for 12 hours. After the reaction was complete, the mixture was concentrated, and the residue was subjected to silica gel column chromatography (petroleum ether:ethyl acetate (v / v) = 5:1) to obtain compound 3B (10.0 g, 73.1%). LCMS(ESI): m / z = 287.1[M+H] + .

[0079] Step 2: Dibromohydantoin (32.0 g, 111.88 mmol) was dissolved in dichloromethane (300 mL), pyridine hydrogen fluoride (22.2 g, 223.76 mmol) was added at -78°C, and a dichloromethane solution of compound 3B (8.0 g, 27.97 mmol) (80 mL) was added dropwise. After the addition was complete, the mixture was allowed to rise naturally to room temperature and reacted for 2 hours. Water (300 mL) was added and extracted, and the aqueous phase was extracted again with dichloromethane (300 mL). The combined organic phase was washed with saturated saline solution (300 mL), dried over anhydrous sodium sulfate, filtered, concentrated, and then subjected to silica gel column chromatography (petr...

Claims

1. A compound represented by formula (I), its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, 【Chemistry 1】 A is selected from a 3-20 membered heterocycloalkyl group or a 5-20 membered heteroaryl group, the heterocycloalkyl group and heteroaryl group contain 1 to 5 heteroatoms selected from N, O, and S, and the heterocyclic group and heteroaryl group optionally contain 0 to 5 R Ａ Replaced by, B is bond, C ３－１０ Cycloalkyl groups, C ６－１２ Selected from an aryl group, a 3-12 membered heterocycloalkyl group, or a 5-12 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1 to 5 heteroatoms selected from N, O, and S, and the cycloalkyl group, aryl group, heterocyclyl group, and heteroaryl group optionally contain 0 to 5 R Ｂ Replaced by, C is C ３－１２ Cycloalkyl groups, C ６－１０ Selected from an aryl group, a 3-14 membered heterocycloalkyl group, or a 5-14 membered heteroaryl group, wherein the heterocycloalkyl group and heteroaryl group contain 1 to 5 heteroatoms selected from N, O, and S, and the cycloalkyl group, heterocycloalkyl group, aryl group, and heteroaryl group optionally contain 0 to 5 R Ｃ Replaced by, L １ 、L ２ are each independently selected from W １ -R Ｌ -W ２ and the left side of L １ is connected to A, and the left side of L ２ is connected to B R Ｌ C １－４ Alkylene group, C ２－４ Alkenylene group, C ２－４ Alkynylene group, C ３－６ A cycloalkyl group, a 5-12 membered heteroaryl group, or a 4-10 membered heterocycloalkyl group containing 1-3 heteroatoms selected from N, O, and S, wherein the alkylene group, alkenylene group, alkylylene group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally further contain 1-4 R Ｌ１ Replaced with R Ｌ１ These are, independently, halogen, =O, and C. １－４ alkyl group, C ２－４ Alkenyl group, C １－４ The alkyl group, alkoxy group, cycloalkyl group, and 5-6 membered heteroaryl group are selected from a halogen, CN, OH, and C. １－４ Alkoxy groups and NH ２ Substituted with 1 to 4 substituents selected from, W １ , W ２ Each is independent, combined, C １－４ Alkylene group, -O-, -S-, -S(=O)-, -S(=O) ２ -, -NR Ｗ１ -, -CONR Ｗ１ -, -NR Ｗ１ CO-, -C(=O)O-, -OC(=O)-, -C(=S)-, -C(=O)-, -(C １－４ Alkylene)-NR Ｗ１ Selected from CO-, the alkylene group may optionally be further a halogen, =O, C １－４ Alkyl, CN, OH and NH ２ Substituted with 1 to 4 groups selected from, R Ｗ１ H, C １－４ Selected from alkyl groups and halogens, One option is L １ teeth, 【Chemistry 2】 Selected from, 【Transformation 3】 The terminal end is connected to ring B, R Ａ These are, independently, halogen, =O, CN, OH, COOH, and C. １－４ alkyl group, C １－４ Alkoxy group, C ２－６ Alkenyl group, C ２－６ Alkynyl group, 5-12 membered heteroaryl group, -NR ａ CO-C ３－６ Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -O-C ３－６ Cycloalkyl group, -C １－４ Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C １－４ Alkyl-(4-12 member heterocycloalkyl), -C １－４ Alkyl-O-(4-12 member heterocycloalkyl), -C １－４ Alkyl-O-C ３－６ Cycloalkyl group, -C １－４ Alkyl-OC(=O)-(4-12 member heterocycloalkyl),-C １－４ Alkyl-OC(=O)-NR ａａ -C ３－６ Cycloalkyl groups, -NR ａａ R ｂｂ , -SO ２ -C １－４ Alkyl alkyl group, -C ３－６ Cycloalkyl groups, -NR ａａ -C ３－６ Cycloalkyl groups, 【Chemistry 4】 Selected from the alkyl group, alkenyl group, alkynyl group, heteroaryl group, cycloalkyl group, and heterocycloalkyl group, optionally further include halogens, OH, and NH. ２ , CN, C １－４ Alkoxy group, -O-halo C １－４ alkyl group, C １－４ Alkyl alkyl group, -C １－４ Alkylhydroxy group, -C(=O)C １－４ Alkyl, Halo C １－４ Substituted with 1 to 5 groups selected from alkyl groups, One option is two R's. Ａ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Substituted with 1 to 4 groups selected from alkyl groups, R Ｂ These are, independently, halogen, CN, =O, OH, -SF ５ , C １－４ alkyl group, C １－４ Alkoxy group, C ２－６ Alkenyl group, C ２－６ Selected from alkynyl groups, the alkyl group, alkoxy group, alkenyl group, and alkynyl group may optionally be further selected from halogens and C １－２ Substituted with a group selected from alkyl groups, R Ｃ is, independently of each other, D, halogen, CN, =O, OH, C １－４ alkyl group, C １－４ alkoxy group, haloC １－４ alkyl group, haloC １－４ alkoxy group, C ３－５ cycloalkyl group, C ６－１０ cycloalkyl group, C ２－４ alkenyl group, C ２－４ alkynyl group, -SCF ３ ,-SF ５ , 5- to 6-membered heteroaryl group, 8- to 10-membered bicyclic heteroaryl group, 4- to 12-membered heterocycloalkyl group, -N=S(=O)R ａａ R ｂｂ , -P(=O)R ａａ R ｂｂ , -NR ａ S(=O) ２ C １－４ alkyl group, -NR ａ P(=O)(C １－４ alkyl) ２ , -NR ａ S(=O) ２ NR ａａ R ｂｂ , -NR ａ C(=O)-C ３－６ cycloalkyl group, -C(=O)NR ａ -C ３－６ cycloalkyl group, -O-C ３－６ cycloalkyl group, -O-C ５－１１ spirocycloalkyl group, -O-(4- to 12-membered heterocycloalkyl), -O-(5- to 6-membered heteroaryl), -NR ａ -C ３－６ cycloalkyl group, -NR ａ -(4- to 12-membered heterocycloalkyl), -NR ａ -(5- to 6-membered heteroaryl), -NR ａ S(=O) ２ -C ３－６ cycloalkyl group, -C １－４ alkyl-(5- to 6-membered heteroaryl), -C １－４ alkyl-(C ６－１０ aryl), -C １－４ Alkyl-(4-6 member heterocycloalkyl), -NR ａ C(=O)-O-R ａ , - (C １－４ Alkyl) ｎ -O-(C １－４ Alkyl) ｎ - (4-6 member heterocycline), -NR ａ C(=O)-(4-6 member heterocyclyl),-C(=O)NR ａ - (4-6 member heterocycline), 【Transformation 5】 -C (=O) -C ３－６ Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, spirocycloalkyl group, and heterocyclyl group may optionally be further replaced with halogens, OH, or NH ２ , CN, C １－４ Alkyl, Halo C １－４ Alkyl alkyl groups, deuterated C １－４ Alkyl alkyl group, =O, -C (=O)C １－４ Alkyl alkyl group, -NH-C(=O)C １－４ Alkyl alkyl group, -S (=O) ２ C １－４ Substituted with 1 to 4 groups selected from alkyl groups, n is independently selected from 0 or 1. R ａ H, halogen, 3-6 membered cycloalkyl group, C １－４ Selected from alkyl groups and halo-3 to 6-membered cycloalkyl groups, R ａａ , R ｂｂ These are H, halogen, =O, and C, respectively, independently. １－４ alkyl group, C １－４ Alkylhydroxy group, halo C １－４ alkyl group, C １－４ Alkoxy group or halo C １－４ Selected from alkoxy groups, One option is R ａａ , R ｂｂ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Substituted with 1 to 4 groups selected from alkyl groups, One option is two R's. Ｃ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Substituted with 1 to 4 groups selected from alkyl groups, One option is R Ｂ , R Ｃ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Compounds, stereoisomers thereof, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts substituted with one to four groups selected from alkyl groups.

2. A is selected from a 5-6 member monocyclic heteroaryl group, a 6-10 member bicyclic heterocycloalkyl group, a 9-10 member bicyclic heteroaryl group, a 10-14 member tricyclic heterocycloalkyl group, and a 10-14 member tricyclic heteroaryl group, and the heterocycloalkyl group and heteroaryl group optionally have 1 to 5 R Ａ Replaced by, R Ａ These are, independently, halogen, =O, CN, OH, COOH, and C. １－４ alkyl group, C １－４ Alkoxy group, 5-6 membered heteroaryl group, -NRaCO-C ３－６ Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -O-C ３－６ Cycloalkyl group, -C １－４ Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C １－４ Alkyl-(4-12 member heterocycloalkyl), -C １－４ Alkyl-O-(4-12 member heterocycloalkyl), -C １－４ Alkyl-O-C ３－６ Cycloalkyl group, -C １－４ Alkyl-OC(=O)-(4-12 member heterocycloalkyl),-C １－４ Alkyl-OC(=O)-NR ａａ -C ３－６ Cycloalkyl groups, -NR ａａ R ｂｂ , -SO ２ -C １－４ Alkyl alkyl group, -C ３－６ Cycloalkyl groups, -NR ａａ -C ３－６ Cycloalkyl groups, 【Transformation 6】 Selected from, the alkyl group, heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further, halogen, OH, or NH ２ , CN, C １－４ alkyl group, C １－２ Alkoxy group, -C １－２ Alkylhydroxy group, -C(=O)C １－２ Alkyl, Halo C １－２ Substituted with 1 to 5 groups selected from alkyl groups, One option is two R's. Ａ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Substituted with 1 to 4 groups selected from alkyl groups, B is a bond, a 4-7 member monocyclic heterocycloalkyl group, C ３－８ Selected from cycloalkyl groups, 5-6 membered heteroaryl groups, 5-6 membered heterocycloalkyl groups condensed from 5-6 membered heteroaryl groups, 5-12 membered spirocyclic heterocycloalkyl groups, 3-6 membered cycloalkyl group condensed from 5-6 membered heterocycloalkyl groups, and benzo-5-6 membered heterocycloalkyl groups, wherein the heterocycloalkyl group, heteroaryl group, cycloalkyl group, and aryl group optionally have 1 to 5 R groups. Ｂ Replaced by, R Ｂ These are, independently, halogen, =O, and C. １－２ Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. C is selected from a 5-6 member monocyclic heteroaryl group, a phenyl group, a phenyl group-condensed 4-6 member carbocyclyl group, a phenyl group-condensed 4-6 member heterocycloalkyl group, a 5-6 member heterocycloalkyl group-condensed 5-6 member heteroaryl group, a 5-6 member heteroaryl group-condensed 5-6 member carbocyclyl group, an 8-12 member tricyclic cycloalkyl group, and an 8-14 member tricyclic heterocyclyl group. The heteroaryl group, heterocycloalkyl group, and heterocyclyl group contain 1-4 heteroatoms selected from N, O, and S. The phenyl group, heterocycloalkyl group, and carbocyclyl group optionally contain 1-5 R atoms. Ｃ Replaced by, R Ｃ These are D, halogen, CN, =O, and C, respectively, independently. １－２ alkyl group, C １－２ Alkoxy group, Halo C １－２ Alkyl, Halo C １－２ Alkoxy group, C ３－５ Cycloalkyl groups, C ６－１０ Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 4-12 membered heterocycloalkyl groups, -N=S(=O)R ａａ R ｂｂ , -P(=O)R ａａ R ｂｂ , -NR ａ S (=O) ２ C １－４ Alkyl alkyl, -NR ａ P (= O) (C １－４ Alkyl) ２ , -NR ａ S (=O) ２ NR ａａ R ｂｂ , -NR ａ C (= O) - C ３－６ Cycloalkyl groups, -C(=O)NR ａ -C ３－６ Cycloalkyl groups, -O-C ３－６ Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-C ５－１１ Spirocycloalkyl group, -O- (5-6 member heteroaryl), -NR ａ -C ３－６ Cycloalkyl groups, -NR ａ - (4-12 member heterocycloalkyl), -NR ａ - (5-6 member heteroaryl), -NR ａ S (=O) ２ -C ３－６ Cycloalkyl group, -C １－４ Alkyl-(5-6 member heteroaryl), -C １－４ Alkyl-(C) ６－１０ Aryl), -C １－４ Alkyl-(4-6 member heterocycloalkyl), -NR ａ C(=O)-O-R ａ , - (C １－４ Alkyl) ｎ -O-(C １－４ Alkyl) ｎ - (4-6 member heterocycline), -NR ａ C(=O)-(4-6 member heterocycloalkyl),-NR ａ C(=O)-(5-6 member heteroaryl),-C(=O)NR ａ - (4-6 member heteroaryl), - C(=O)NR ａ - (4-6 member heterocycloalkyl), 【Transformation 7】 -C (=O) -C ３－６ Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, spirocycloalkyl group, and heterocyclyl group may optionally be further replaced with halogens, OH, or NH ２ , CN, C １－４ Alkyl, Halo C １－４ Alkyl alkyl groups, deuterated C １－４ Alkyl alkyl group, =O, -C (=O)C １－４ Alkyl alkyl group, -NH-C(=O)C １－４ Alkyl alkyl group, -S (=O) ２ C １－４ Substituted with 1 to 4 groups selected from alkyl groups, R ａ H, halogen, 3-6 membered cycloalkyl group, C １－２ Selected from alkyl groups and halo-3 to 6-membered cycloalkyl groups, R ａａ , R ｂｂ These are H, halogen, =O, and C, respectively, independently. １－４ alkyl group, C １－４ Alkylhydroxy group, halo C １－４ alkyl group, C １－４ Alkoxy group or halo C １－４ Selected from alkoxy groups, One option is R ａａ , R ｂｂ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Substituted with 1 to 4 groups selected from alkyl groups, One option is R Ｂ , R Ｃ These, together with the carbon atoms bonded to them, form a 5-6 membered heterocycline group, and the heterocycline group can optionally be further enriched with halogens, C １－２ Substituted with 1 to 4 groups selected from alkyl groups, L １ C １－２ Alkylene group, -C(=O)-C １－２ Alkylene-,-N(C) １－２ Alkylene)-C(=O)-C １－２ Alkylene-,-NH-C(=O)-C １－２ Alkylene-, -S (=O) ２ -C １－２ Alkylene-,-C(=S)-C １－２ 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S １－２ Alkylene-,-C(=O)-C ３－６ Cycloalkyl-, -C １－２ Alkylene-C(=O)-, -C(=O)-C(=O)-, C ２－４ Alkenylene group, -C(=O)-C ２－４ Alkenylene group, -C(=O)-NH-, -C(=O)-N(CH ３ )-, -C(=O)-O-, 5-6 member heteroaryl-C １－２ Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C ３－６ Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C １－２ Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C １－２ Alkylene-, -C １－２ Alkylene-4 to 6-membered monocyclic heterocycloalkyl-, -C １－２ Alkylene-NH-C(=O)-C １－２ Selected from alkylene, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R Ｌ１ Replaced with R Ｌ１ These are, independently, halogen, =O, and C. １－２ Alkyl, Halo C １－２ alkyl group, C ２－４ Alkenyl group, C １－２ Alkoxy group, Halo C １－２ Alkoxy group, 3-6 membered cycloalkyl group, 5-6 membered heteroaryl group, C １－２ Alkyl-C １－２ Selected from alkoxy, One option is L １ teeth, 【Transformation 8】 Selected from, 【Chemistry 9】 The terminal end is connected to ring B, L ２ C １－２ Alkylene group, C ２－４ Alkenylene group, C ２－４ Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C １－２ The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R Ｌ１ Replaced with R Ｌ１ These are, independently, halogen, =O, and C. １－２ Alkyl, Halo C １－２ alkyl group, C ２－４ Alkenyl group, C １－２ Alkoxy group, Halo C １－２ Selected from alkoxy groups and 3-6 membered cycloalkyl groups, As a condition, L ２ If selected from -O- and -NH-, L １ The compound according to claim 1, its stereoisomer, deuteride, solvate, cocrystal or pharmaceutically acceptable salt, wherein is not selected from -C(=O)- or B1 is not selected from the bond.

3. It has the structure of formulas (I-1a), (I-2), (I-3), (I-4), (I-5), and (I-1b), 【Chemistry 10】 A1 is, 【Chemistry 11】 Selected from the basis, B1 is bond, 【Chemistry 12】 Selected from the basis, Here, 【Chemistry 13】 The end is L １ or L １ａ or L １ｂ It is connected to, 【Chemistry 14】 The end is L ２ or L ２ａ It is connected to, C1 is, 【Chemistry 15】 Selected from the basis, C2 is, 【Chemistry 16】 Selected from the basis, As a condition, C2 【Chemistry 17】 If selected from, L ２ is not selected from the join, or C2 is [Chemistry 18] Selected from, L ２ If is selected from the join, n3 is not selected from 0, R Ｃ It is not F, R １ , R ２ , R ３ , R ４ Each is independently selected from H and halogen, and the condition is R １ , R ２ , R ３ , R ４ It is not possible to select from H at the same time. One option is R ３ , R ４ They come together to form = O, Equation (I-3) satisfies one or more of the following conditions: (1) L １ａ C １－２ Alkylene group, -C(=O)-CH(CH ３ )-, -C(=O)-C(R ａ R ｂ )-,-N(C １－２ Alkylene)-C(=O)-C １－２ Alkylene-,-NH-C(=O)-C １－２ Alkylene-, -S (=O) ２ -C １－２ Alkylene-,-C(=S)-C １－２ 4-6 membered heterocycloalkyl-C containing 1-3 heteroatoms selected from alkylene-, -N, O, and S １－２ Alkylene-,-C(=O)-C ３－６ Cycloalkyl-, -C １－２ Alkylene-C(=O)-, -C(=O)-C(=O)-, C ２－４ Alkenylene group, -C(=O)-C ２－４ Alkenylene group, -C(=O)-NH-, -C(=O)-N(CH ３ )-, -C(=O)-O-, 5-6 member heteroaryl-C １－２ Alkylene-, 4-6 membered monocyclic heterocycloalkyl group, C ３－６ Cycloalkyl group, 5-6 membered heteroaryl group, -C(=O)-, 4-6 membered monocyclic heterocycloalkyl-C １－２ Alkylene-, 4-6 membered monocyclic heterocycloalkyl-C(=O)-C １－２ Alkylene-, -C １－２ Alkylene-4 to 6-membered monocyclic heterocycloalkyl-, -C １－２ Alkylene-NH-C(=O)-C １－２ Selected from alkylene, the alkylene group, heterocycloalkyl group, cycloalkyl group, alkenylene group, heteroaryl group, and heterocycloalkyl group may optionally be further further with 1 to 3 R Ｌ１ Replaced with R Ｌ１ These are, independently, halogen, =O, and C. １－２ Alkyl, Halo C １－２ alkyl group, C ２－４ Alkenyl group, C １－２ Alkoxy group, Halo C １－２ Selected from alkoxy groups and 3-6 membered cycloalkyl groups, L １ａ The right side is connected to the B1 ring, R ａ , R ｂ These are, independently, H, halogen, 3-6 membered cycloalkyl group, and C. １－２ Selected from alkyl groups, with the condition being R ａ , R ｂ It is not selected from H at the same time. L ２ａ C ２－４ Alkenylene group, C ２－４ Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C １－２ The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R Ｌ１ Replaced with R Ｌ１ These are, independently, halogen, =O, and C. １－２ Alkyl, Halo C １－２ alkyl group, C ２－４ Alkenyl group, C １－２ Alkoxy group, Halo C １－２ Selected from alkoxy groups and 3-6 membered cycloalkyl groups, and as a condition, L １ａ is selected from -C (=O)-, L ２ａ If B1 is selected from -NH- or -O-, then B1 is not selected from the joins. (2) L １ａ is -C(=O)-CH ２ -, -C(=O)-CH ２ CH ２ - Selected from, L ２ａ If a combination is selected, then at least one R Ｃ１ =O, 5-6 member heteroaryl group, 8-10 member bicyclic heteroaryl group, 4-12 member heterocycloalkyl group, -N=S(=O)RaaRbb, -P(=O)RaaRbb, -NRaS(=O) ２ C １－４ Alkyl alkyl group, -NRaP(=O)(C １－４ Alkyl) ２ , -NRaS(=O) ２ NRaaRbb, -NRaC(=O)-C ３－６ Cycloalkyl group, -C(=O)NRa-C ３－６ Cycloalkyl groups, -O-C ３－６ Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR ａ -C ３－６ Cycloalkyl groups, -NR ａ - (4-12 member heterocycloalkyl), -NR ａ - (5-6 member heteroaryl), -NR ａ S (=O) ２ -C ３－６ Cycloalkyl groups, cubanes, -C １－４ Alkyl-(5-6 member heteroaryl), -C １－４ Alkyl-(C) ６－１０ Aryl), -C １－４ Alkyl-(4-6 member heterocycloalkyl), -NR ａ C(=O)-O-R ａ , - (C １－４ Alkyl) ｎ -O-(C １－４ Alkyl) ｎ - (4-6 member heterocycline), -NR ａ C(=O)-(4-6 member heterocyclyl),-C(=O)NR ａ - (4-6 member heteroaryl), 【Chemistry 19】 Selected from the alkyl group, cycloalkyl group, heteroaryl group, heterocycloalkyl group, and cubane, optionally further include halogens, OH, and NH. ２ , CN, C １－４ Alkyl, Halo C １－４ Alkyl alkyl groups, deuterated C １－４ Alkyl alkyl group, =O, -C (=O)C １－４ Alkyl alkyl group, -NH-C(=O)C １－４ Alkyl alkyl group, -S (=O) ２ C １－４ Substituted with 1 to 4 groups selected from alkyl groups, (3) L １ａ is -C(=O)-CH ２ -, -C(=O)-CH ２ CH ２ - Selected from, L ２ａ C １－２ Alkylene group, C ２－４ Alkenylene group, C ２－４ Alkynylene group, -C(=O)-NH-, -NH-, -O-, -N(C １－２ The alkylene group, alkenylene group, and alkynylene group are selected from -C(=O)-, and the alkylene group, alkenylene group, and alkynylene group may be further optionally further added to 1 to 3 R Ｌ１ Replaced with R Ｌ１ These are, independently, halogen, =O, and C. １－２ Alkyl, Halo C １－２ alkyl group, C ２－４ Alkenyl group, C １－２ Alkoxy group, Halo C １－２ Selected from alkoxy groups and 3-6 membered cycloalkyl groups, (4) L １ａ is -C(=O)-CH ２ - Selected from, L ２ａ If a combination is selected, then at least one R Ａ is C １－２ If an alkyl group is not selected, the compound 【Chemistry 20】 Instead, L １ｂ The group is selected from a bond, a 4-6 member monocyclic heterocycloalkyl group, and -C(=O)-NH-, and the heterocycloalkyl group can optionally be further a halogen, =O, C １－２ Substituted with 1 to 4 groups selected from alkyl groups, As one option, 【Chemistry 21】 teeth, 【Chemistry 22】 Selected from, R Ａ These are, independently, halogen, =O, and C. １－２ Alkyl alkyl group, -CF ３ , 5-6 member heteroaryl group, -NRaCO-C ３－６ Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -C １－２ Alkyl-(5-6 member heteroaryl), -O-(4-12 member heterocycloalkyl), -C １－２ Alkyl-(4-12 member heterocycloalkyl), -C １－２ Alkyl-O-(4-12 member heterocycloalkyl), -C １－２ Alkyl-O-C ３－６ Cycloalkyl group, -C １－２ Alkyl-OC(=O)-(4-12 member heterocycloalkyl),-C １－２ Alkyl-OC(=O)-NR ａａ -C ３－６ Cycloalkyl groups, -NR ａａ R ｂｂ , -SO ２ -C １－２ Alkyl alkyl group, -C ３－６ Cycloalkyl groups, -NR ａａ -C ３－６ Cycloalkyl groups, 【Chemistry 23】 The alkyl group is selected from, and optionally further, OH, NH ２ , CN, C １－２ alkyl group, C １－２ The group is substituted with 1 to 4 groups selected from alkoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group are optionally further substituted with halogens, OH, and NH. ２ , CN, C １－２ Alkyl alkyl group, -C １－２ Alkylhydroxy, Halo C １－２ Alkyl alkyl group, -C(=O)C １－２ alkyl group, C １－２ Substituted with 1 to 4 groups selected from alkoxy groups, R Ａ１ These are, independently, halogen, =O, CN, OH, COOH, and C. １－４ alkyl group, C １－４ Alkoxy group, 5-6 membered heteroaryl group, -SO ２ -C １－４ Alkyl alkyl group, -NRaCO-C ３－６ Cycloalkyl groups, 4-12 member heterocycloalkyl groups, -O-C ３－６ Cycloalkyl group, -C １－２ Alkyl-(5-6 member heteroaryl),-NR ａａ R ｂｂ Selected from, the alkyl group, heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further, halogen, OH, or NH ２ , CN, C １－４ Alkyl, Halo C １－４ alkyl group, C １－４ Substituted with 1 to 5 groups selected from alkoxy groups, One option is two R's. Ａ C ３－６ A 4-6 membered carbocyclyl group or a 4-6 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－２ Substituted with 1 to 4 groups selected from alkyl groups, R Ｂ These are, independently, halogen, =O, and C. １－２ Selected from alkyl groups, the alkyl group is optionally further substituted with a halogen. R Ｃ These are D, halogen, and C, respectively, independently. １－２ alkyl group, C １－２ Alkoxy group, Halo C １－２ Alkyl, Halo C １－３ Alkoxy group, C ３－４ Cycloalkyl group, 5-6 membered heteroaryl group, CN, =O, -NH-S (=O) ２ -C １－２ Alkyl alkyl groups, -O- (5-6 member heteroaryl groups), -O-C ３－６ Cycloalkyl groups, -O- (4-12 member heterocycloalkyl groups), 【Chemistry 24】 Selected from, the alkyl group, heteroaryl group, and cycloalkyl group may optionally be further a halogen, C １－２ Alkyl, Halo C １－２ Substituted with 1 to 4 groups selected from alkyl groups, R Ｃ１ These are, independently, halogen and C １－２ Alkyl, Halo C １－２ Alkyl, Halo C １－３ Alkoxy group, C ３－５ Cycloalkyl groups, C ６－１０ Cycloalkyl groups, 5-6 membered heteroaryl groups, 8-10 membered bicyclic heteroaryl groups, 6-9 membered spirocyclic heterocycloalkyl groups, 7-10 membered fused heterocycloalkyl groups, 6-8 membered crosslinked heterocycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, -N=S(=O)R ａａ R ｂｂ , -P(=O)R ａａ R ｂｂ , -NR ａ S (=O) ２ C １－４ Alkyl alkyl, -NR ａ P (= O) (C １－４ Alkyl) ２ , -NR ａ S (=O) ２ NR ａａ R ｂｂ , -NR ａ C (= O) - C ３－６ Cycloalkyl groups, -C(=O)NR ａ -C ３－６ Cycloalkyl groups, -O-C ３－６ Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NR ａ -C ３－６ Cycloalkyl groups, -NR ａ - (4-12 member heterocycloalkyl), -NR ａ - (5-6 member heteroaryl), -NR ａ S (=O) ２ -C ３－６ Cycloalkyl group, -C １－４ Alkyl-(5-6 member heteroaryl), -C １－４ Alkyl-(C) ６－１０ Aryl), -C １－４ Alkyl-(4-6 member heterocycloalkyl), -NR ａ C(=O)-O-R ａ , - (C １－４ Alkyl) ｎ -O-(C １－４ Alkyl) ｎ - (4-6 member heterocycline), -NR ａ C(=O)-(4-6 member heterocycloalkyl),-NR ａ C(=O)-(5-6 member heteroaryl),-C(=O)NR ａ - (5-6 member heteroaryl), 【Chemistry 25】 -C (=O) -C ３－６ Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the alkyl group, cycloalkyl group, heteroaryl group, and heterocycloalkyl group may optionally be further composed of halogens, OH, or NH ２ , CN, C １－４ Alkyl, Halo C １－４ Alkyl alkyl groups, deuterated C １－４ Alkyl alkyl group, =O, -C (=O)C １－４ Alkyl alkyl group, -NH-C(=O)C １－４ Alkyl alkyl group, -S (=O) ２ C １－４ Substituted with 1 to 4 groups selected from alkyl groups, R ａａ , R ｂｂ These are H, halogen, =O, and C, respectively, independently. １－４ alkyl group, C １－４ Alkylhydroxy group, halo C １－４ alkyl group, C １－４ Alkoxy group or halo C １－４ Selected from alkoxy groups, One option is R ａａ , R ｂｂ C ３－６ A 4-10 membered carbocyclyl group or a 4-10 membered heterocyclyl group is formed, and the carbocyclyl group or heterocyclyl group can optionally be further composed of a halogen, OH, or NH. ２ , CN, C １－４ Substituted with 1 to 4 groups selected from alkyl groups, n1, n2, and n3 are each independently selected from 0, 1, 2, 3, 4, or 5, and the compound according to claim 2, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt thereof.

4. In compounds of formulas (I-1a), (I-2), (I-3), (I-4), (I-5), and (I-1b), R Ａ These are, independently, F, Cl, =O, CN, methyl group, ethyl group, -NHCO-C ３－６ Cycloalkyl groups, 4-6 membered monocyclic heterocycloalkyl groups, 5-membered heteroaryl groups, 6-membered heteroaryl groups, -C １－２ Alkyl-(5-membered heteroaryl), -C １－２ Alkyl-(6-membered heteroaryl), -O-(4-6 membered monocyclic heterocycloalkyl), -C １－２ Alkyl-(4-6 membered monocyclic heterocycloalkyl), -C １－２ Alkyl-O-(4-6 membered monocyclic heterocycloalkyl), -C １－２ Alkyl-O-C ３－６ Cycloalkyl group, -C １－２ Alkyl-OC(=O)-(4-6 member monocyclic heterocycloalkyl),-C １－２ Alkyl-OC(=O)-NH-C ３－６ Cycloalkyl groups, -NHR ａａ , -SO ２ CH ３ , cyclopropyl group, cyclobutyl group, -NH-cyclopropyl, -NH-cyclobutyl, oxacyclopentyl group, 【Chemistry 26】 -CF ３ , selected from 7-10 membered bicyclic heterocycloalkyl groups, the methyl group and ethyl group may optionally be further OH, NH ２ The group is substituted with 1 to 4 groups selected from CN, methyl, ethyl, and methoxy groups, and the heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further substituted with F, Cl, OH, or NH ２ CN, methyl group, ethyl group, -CHF ２ ien-CH ２ F, -CF ３ -C(=O)CH ３ , -O-CH ３ , -O-CH ２ CH ３ Substituted with 1 to 4 groups selected from, One option is two R's. Ａ These, together with the carbon atoms bonded to them, form a 5-6 membered heterocyclyl group, and the heterocyclyl group can optionally be further composed of F, Cl, OH, or NH ２ , substituted with 1 to 4 groups selected from CN, methyl groups, and ethyl groups, R Ａ１ These are F, Cl, =O, CN, OH, COOH, and -SO, respectively, and are independent of each other. ２ CH ３ methyl group, ethyl group, -O-C ３－６ Cycloalkyl groups, -NHR ａａ The group is selected from a 5-membered heteroaryl group and a 4- to 6-membered heterocycloalkyl group, and the methyl group, ethyl group, cycloalkyl group, and 4- to 6-membered heterocycloalkyl group may be optionally further F, Cl, OH, or NH ２ CN, methyl group, ethyl group, -CHF ２ ien-CH ２ F, -CF ３ , substituted with 1 to 5 groups selected from methoxy groups, R Ｂ Each of these is independently selected from F, Cl, =O, methyl group, and ethyl group, and the methyl group and ethyl group are optionally further substituted with F and Cl groups, respectively. R Ｃ These are, independently, D, F, Cl, methyl group, ethyl group, and -CHF. ２ ien-CH ２ F, -CF ３ ien-CH ２ CF ３ ien-CH ２ CHF ２ ien-CH ２ CH ２ F, -OCHF ２ , -OCH ２ F, -OCF ３ , -OCH ２ CF ３ , -OCH(CH ３ ) CF ３ Cyclopropyl, cyclobutyl group, 5-membered heteroaryl group, 6-membered heteroaryl group, -CN, =O, -NH-S (=O) ２ -C １－２ Alkyl alkyl group, -O- (5-membered heteroaryl), -O-C ３－６ Cycloalkyl groups, -O- (4-6 membered monocyclic heterocycloalkyl groups), 【Chemistry 27】 Selected from the methyl group, ethyl group, cyclopropyl group, cyclobutyl group, heteroaryl group, cycloalkyl group, and heterocycloalkyl group, optionally further F, Cl, methyl group, ethyl group, and -CHF ２ ien-CH ２ F, -CF ３ Substituted with 1 to 4 groups selected from, R Ｃ１ These are, independently, F, Cl, methyl group, ethyl group, and -CHF. ２ ien-CH ２ F, -CF ３ ien-CH ２ CF ３ ien-CH ２ CHF ２ ien-CH ２ CH ２ F, -OCHF ２ , -OCH ２ F, -OCF ３ , -OCH ２ CF ３ , -OCH(CH ３ ) CF ３ Cyclopropyl, cyclobutyl group, cyclopentyl group, cubane, 5-membered heteroaryl group, 6-membered heteroaryl group, 8-membered fused cyclic heteroaryl group, 9-membered fused cyclic heteroaryl group, 10-membered fused cyclic heteroaryl group, 7-8 membered spirocyclic heterocycloalkyl group, 8-9 membered fused cyclic heterocycloalkyl group, 7-membered crosslinked cyclic heterocycloalkyl group, 4-6 membered monocyclic heterocycloalkyl group, -N=S(=O)R ａａ R ｂｂ , -P(=O)R ａａ R ｂｂ , -NR ａ S (=O) ２ C １－４ Alkyl alkyl, -NR ａ P (= O) (C １－４ Alkyl) ２ , -NR ａ S (=O) ２ NR ａａ R ｂｂ , -NR ａ C (= O) - C ３－６ Cycloalkyl groups, -C(=O)NR ａ -C ３－６ Cycloalkyl groups, -O-C ３－６ Cycloalkyl groups, -O-(4-6 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -NH-C ３－６ Cycloalkyl groups, -NH- (4-6 member heterocycloalkyl groups), -NH- (5-6 member heteroaryl groups), -NH-S (=O) ２ -C ３－６ Cycloalkyl group, -C １－２ Alkyl-(5-membered heteroaryl), -C １－２ Alkyl-(6-membered heteroaryl), -C １－２ Alkylphenyl, -C １－２ Alkyl-(4-6 member heterocycloalkyl), -NR ａ C(=O)-O-R ａ , - (C １－２ Alkyl) ｎ -O-(C １－２ Alkyl) ｎ - (4-6 member heterocycline), -NR ａ C(=O)-(4-6 member heterocyclyl),-C(=O)NR ａ - (4-6 member heterocycline), 【Chemistry 28】 -C (=O) -C ３－６ Selected from cycloalkyl groups, -C(=O)-(4-12 member heterocycloalkyl groups), and -C(=O)-(5-6 member heteroaryl groups), the cyclopropyl group, cyclobutyl group, cyclopentyl group, alkyl group, cycloalkyl group, heterocyclyl group, heteroaryl group, heterocycloalkyl group, and cubane may optionally be further F, Cl, OH, or NH ２ CN, methyl group, ethyl group, deuterated methyl group, -CHF ２ ien-CH ２ F, -CF ３ ien-CH ２ CF ３ ien-CH ２ CHF ２ ien-CH ２ CH ２ F, =O, -C(=O)C １－４ Alkyl alkyl group, -NH-C(=O)C １－４ Alkyl alkyl group, -S (=O) ２ C １－２ Substituted with 1 to 4 groups selected from alkyl groups, R ａ The group is selected from H, F, Cl, methyl group, ethyl group, cyclopropyl group, cyclobutyl group, cyclopentyl group, and difluorocyclobutyl group. R ａａ , R ｂｂ These are, independently, H, F, Cl, =O, methyl group, ethyl group, and -CH, respectively. ２ -CH ２ -OH, -CH ２ -OH, -CHF ２ ien-CH ２ F, -CF ３ ien-CH ２ CF ３ ien-CH ２ CHF ２ ien-CH ２ CH ２ F, -OCH ３ , -OCH ２ CH ３ , -OCHF ２ , -OCH ２ F, -OCF ３ , -OCH ２ CF ３ , -OCH ２ CHF ２ , -OCH ２ CH ２ Selected from F, One option is R ａａ , R ｂｂ These, together with the carbon atoms bonded to them, form a 4-6 membered heterocyclyl group, and the heterocyclyl group can optionally further contain F, Cl, OH, or NH ２ , is substituted with 1 to 4 groups selected from CN, methyl groups, and ethyl groups, and n1 is selected from 0, 1, 2, or 3. n2 is selected from 0 or 1. n3 is selected from 0, 1, 2, 3 or 4. L １ The bond, vinylidene group, -CH ２ -ien-CH ２ -CH ２ -, 4-6 member monocyclic heterocycloalkyl groups, (4-6 member monocyclic heterocycloalkyl)-C(=O)-CH ２ -,-(4-6 member monocyclic heterocycloalkyl)-CH ２ -ien-CH ２ -(4-6 member monocyclic heterocycloalkyl)-, -CH(CH ３ )NHC(=O)-CH ２ -ien-CH ２ NHC(=O)-CH ２ -, -S (=O) ２ -CH ２ -, -C(=S)-CH ２ -, -C(=O)-C ３－６ Cycloalkyl groups, -C(=O)-CH(CH ３ )-, -C(=O)-CH(C ３－６ Cycloalkyl)-,-C(=O)-CF ２ -, -C(=O)-C(CH ３ ) ２ -ien-CH ２ -C(=O)-, -C(=O)-C(=O)-, C ３－６ Cycloalkyl group, -(5-6 member heteroaryl)-CH ２ -, 5-6 member heteroaryl group, -C(=O)-, -C(=O)-CH ２ -, -N(CH ３ ) - CH ２ -, -CF ２ -CH ２ -, -C(=O)-C ２－４ Alkenylene group, -C(=O)-O-, -C(=O)-NH-, -C(=O)-N(CH ３ ) - Selected from the -CH ２ -, alkenylene group, cycloalkyl group, heterocycloalkyl group, heteroaryl group, optionally further 1 to 3 R Ｌ１ Replaced with R Ｌ１ These are, independently, F, Cl, Br, =O, methyl group, ethyl group, and -CF. ３ ,-CHF ２ ien-CH ２ F, vinyl group, propenyl group, methoxy group, ethoxy group, -OCF ３ , -OCHF ２ , -OCH ２ F is selected from cyclopropyl group, cyclobutyl group, methyl-methoxy, and 5-membered heteroaryl group. One option is L １ teeth, 【Chemistry 29】 Selected from, 【Transformation 30】 The terminal end is connected to ring B, L ２ The bond consists of a vinylidene group, an ethynylene group, and -CH ２ -ien-CH ２ -CH ２ -, -O-, -NH-, -C(=O)-, -N(CH ３ A compound, stereoisomer, deuteride, solvate, cocrystal or pharmaceutically acceptable salt thereof, selected from ) - the compound according to claim 3.

5. Having the structure of formula (II), 【Chemistry 31】 Ring A may optionally have one, two, or three additional R rings. Ａ The following structure will be replaced by: 【Chemistry 32】 Select from, or 【Transformation 33】 Selected from, het is a five-membered heteroaryl group, and the heteroaryl group can optionally be a halogen, C １－２ Alkyl, Halo C １－２ Alkyl alkyl groups, deuterated C １－２ Substituted with one or two groups selected from alkyl groups, Each R Ａ These are, independently, halogen, CN, and C. １－４ alkyl group, C １－４ Alkoxy group, Halo C １－４ Alkyl alkyl group, -O-C ３－６ Cycloalkyl groups, 4-6 member heterocycloalkyl groups, 5-6 member heteroaryl groups, -SO ２ -C １－２ Selected from alkyl groups, the heteroaryl group, cycloalkyl group, and heterocycloalkyl group may optionally be further a halogen, OH, or NH ２ , CN, C １－２ alkyl group, C １－２ Alkoxy group, -C(=O)C １－２ Alkyl, Halo C １－２ Substituted with one or two groups selected from alkyl groups, The C ring is, 【Transformation 34】 The C ring is selected from, and the C ring may optionally be further optionally fitted with 1, 2, or 3 R rings. Ｃ Replaced by, Each R Ｃ These are, independently, halogen and halo C. １－３ Alkyl, Halo C １－４ Alkoxy group, C ３－５ Cycloalkyl group, 5-6 membered heteroaryl group, -O-C ３－６ Cycloalkyl groups, -O-(4-12 member heterocycloalkyl groups), -O-(5-6 member heteroaryl groups), -O-C ５－８ Spirocycloalkyl groups, 【Chemistry 35】 Selected from the heteroaryl group, cycloalkyl group, and spirocycloalkyl group, the heteroaryl group, cycloalkyl group, and optionally further, halogen, C １－２ Alkyl, Halo C １－２ Alkyl alkyl groups, deuterated C １－２ The compound according to claim 1, substituted with one to three groups selected from alkyl groups, stereoisomers, deuterides, solvates, cocrystals, or pharmaceutically acceptable salts thereof.

6. Ring A is, 【Transformation 36】 Selected from, Each R Ｃ Each of them operates independently. 【Chemistry 37】 F, Cl, CF ３ CHF ２ ,CH ２ F, -OCHF ２ , -OCH ２ F, -OCF ３ , -OCH ２ CF ３ , -OCH(CH ３ ) CF ３ , cyclopropyl group, cyclobutyl group, 【Transformation 38】 A compound according to claim 5, its stereoisomer, deuteride, solvate, cocrystal, or pharmaceutically acceptable salt, selected from the above.

7. The compound is selected from one of the structures in Table A, and is a compound according to claim 1, a stereoisomer thereof, a deuteride, a solvate, a cocrystal, or a pharmaceutically acceptable salt thereof.

8. A pharmaceutical composition or pharmaceutical preparation comprising a compound according to any one of claims 1 to 7, a stereoisomer thereof, a deuteride, a solvate, a cocrystal or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier and / or excipient.

9. A pharmaceutical composition or pharmaceutical preparation according to claim 8, comprising 1 to 1500 mg of a compound according to any one of claims 1 to 7, a stereoisomer thereof, a deuteride, a solvate, a cocrystal or a pharmaceutically acceptable salt thereof, and a carrier and / or excipient.

10. Uses of the compound according to any one of claims 1 to 7, its stereoisomer, deuteride, solvate, cocrystal or pharmaceutically acceptable salt, or the composition according to claim 8 or 9, in the manufacture of drugs for treating / preventing CHRM4-mediated diseases.

11. The CHRM4-mediated disease is selected from Alzheimer's disease, schizophrenia or psychosis, pain, addiction, sleep disorders, cognitive impairment, Parkinson's disease, Parkinson's disease-levodopa-induced dyskinesia, Huntington's disease, motor disorders, dry mouth, pulmonary hypertension, chronic obstructive pulmonary disease, asthma, urinary incontinence, glaucoma, trisomy 21, cerebral amyloid angiopathy, dementia, Dutch-type hereditary amyloidosis-induced cerebral hemorrhage, prion disease, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, pancreatitis, inclusion body myositis, other peripheral amyloidosis, diabetes mellitus, autism, and atherosclerosis, and is preferably Alzheimer's disease, schizophrenia, pain, addiction, and sleep disorders, as per claim 10.

12. A method for treating a disease in a mammal or a human, the method comprising administering to a subject a therapeutically effective amount of a compound, a stereoisomer thereof, a deuteride thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, wherein the therapeutically effective amount is preferably 1 to 1500 mg, and the disease is Alzheimer's disease, schizophrenia or psychosis, pain, addiction, sleep disorders, cognitive impairment, Parkinson's disease, Parkinson's disease-levodopa-induced dyskinesia, Huntington's disease, motor disorders, dry mouth, pulmonary hypertension A method comprising: a disease selected from chronic obstructive pulmonary disease, asthma, urinary incontinence, glaucoma, trisomy 21, cerebral amyloid angiopathy, dementia, Dutch-type hereditary amyloidosis, prion disease, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, pancreatitis, inclusion body myositis, other peripheral amyloidosis, diabetes mellitus, autism and atherosclerosis, preferably Alzheimer's disease, schizophrenia, pain, addiction and sleep disorders, and preferably Alzheimer's disease, schizophrenia, pain, addiction and sleep disorders.

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