Skin topical composition

Abstract

To provide an external skin composition excellent in easy taking-out in use, spreadability during application and skin compatibility by increasing a value of angular frequency of the sol-gel transition point in dynamic viscoelasticity even if a hydrophobic modified polyether urethane is contained.SOLUTION: There is provided an external skin composition which comprises (A) a hydrophobic modified polyether urethane and (B) one or two or more components selected from the group consisting of nicotinic acid amide, a vitamin C derivative, arbutin and tranexamic acids.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for external use on the skin, more specifically, to a composition containing a hydrophobically modified polyether urethane and one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids. [Background technology]

[0002] In the present invention, hydrophobically modified polyether urethane (HEUR) is a type of water-soluble thickener, and has the property that even if a gel formed once is broken, the gel will return to its original state. It also has a unique thixotropic property. For this reason, for example, in Patent Document 1, hydrophobically modified polyether urethane is used to produce a gel-like oil-in-water emulsion cosmetic that has a unique bouncy elasticity and is stable at high temperatures. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2016-088868 A Summary of the Invention [Problem to be solved by the invention]

[0004] Due to the high restoring property of the gel of the hydrophobically modified polyether urethane as described above, when used in a liquid or paste-like composition for external use on the skin, the composition tends to maintain its original shape even when force is applied with a finger, etc. Therefore, when trying to scoop up a composition containing the hydrophobically modified polyether urethane with a finger, etc., the composition tends to remain in a lump form and easily falls off the finger, making it difficult to remove, and when applying, the composition does not spread well, making it difficult to apply, and does not blend well with the skin.

[0005] One factor that may cause these problems with hydrophobically modified polyether urethane is that, in measurements of the angular frequency dependence of the storage modulus (G') and loss modulus (G") in dynamic viscoelasticity measurements, the angular frequency value of the sol-gel transition point, at which G' = G", is generally small for hydrophobically modified polyether urethane-containing topical skin compositions. As a result, it is thought that the composition is unable to exert sufficient viscosity when subjected to actions that deform the formulation, such as scooping or applying with fingers.

[0006] Therefore, the present invention aims to provide a topical skin composition which contains a hydrophobically modified polyether urethane and has a large angular frequency value at the sol-gel transition point in dynamic viscoelasticity, and which has excellent ease of scooping, spreadability upon application, and compatibility with the skin. [Means for solving the problem]

[0007] As a result of extensive research, the inventors have discovered that the inclusion of (A) a hydrophobically modified polyether urethane and (B) one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids increases the angular frequency value of the sol-gel transition point in the dynamic viscoelasticity of a skin-containing composition, and have thus completed the present invention.

[0008] That is, the present invention provides the following composition for external application to skin: Section 1. (A) hydrophobically modified polyether urethane, and (B) one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids A composition for external application to the skin comprising: Section 2. Item 2. The composition for external application to skin according to Item 1, wherein the component (A) is a hydrophobically modified polyether urethane represented by the following chemical formula (I): R 1 -{(OR 2 ) k -OCONH-R 3 [-NHCOO-(R 4 -O)n -R 5 ] h} m (I) (In the ceremony R 1 represents a hydrocarbon group, R 2 and R 4 each independently represents an alkylene group having 2 to 4 carbon atoms; R 3 represents a hydrocarbon group that may have a urethane bond, which may be linear, branched, or contains an aliphatic ring or an aromatic ring; R 5 represents a branched chain hydrocarbon group; m is an integer of 2 or more, h is an integer of 1 or more, k and n each independently is an integer in the range of 0 to 1000, and k+n≧1. Section 3. Item 3. The composition for external application to skin according to item 1 or 2, further comprising (C) one or more components selected from the group consisting of phenoxyethanol, dipropylene glycol, and amphiphilic components. Section 4. The composition for external application to the skin according to any one of items 1 to 3, wherein the amphiphilic component of the component (C) is one or more selected from the group consisting of a 2-methacryloyloxyethyl phosphorylcholine-containing polymer, a divalent carboxylate ester, an alkanediol having 5 to 10 carbon atoms, and an alkylene oxide derivative represented by the following chemical formula (II): Z-[O-(AO) a (EO) b -(BO) c -H] n (II) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively, and are each independently 0 to 200; a, b, and c are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different, When Z is a hydrogen atom, n is 1. Effect of the Invention

[0009] According to the present invention, a hydrophobically modified polyether urethane-containing topical skin composition can be obtained which has an increased angular frequency value at the sol-gel transition point in dynamic viscoelasticity, and which has excellent ease of scooping during use, spreadability upon application, and compatibility with the skin. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] In this specification, the unit of content "mass%" is synonymous with "g / 100 g".

[0011] The composition for external use on the skin of the present invention contains (A) a hydrophobically modified polyether urethane and (B) one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids.

[0012] [Component (A)] The hydrophobically modified polyether urethane contained in the composition for external use on skin as component (A) of the present invention is a polymer having urethane bonds modified with hydrophobic groups, and is used to thicken and gel aqueous compositions.

[0013] The hydrophobically modified polyether urethane used in the present invention is preferably represented by the following chemical formula (I): R 1 -{(OR 2 ) k -OCONH-R 3 [-NHCOO-(R 4 -O) n -R 5 ] h} m (I) (In the ceremony R 1 represents a hydrocarbon group, R2 and R 4 each independently represents an alkylene group having 2 to 4 carbon atoms; R 3 represents a hydrocarbon group that may have a urethane bond, which may be linear, branched, or contains an aliphatic ring or an aromatic ring; R 5 represents a branched chain hydrocarbon group; m is an integer of 2 or more, h is an integer of 1 or more, k and n each independently is an integer in the range of 0 to 1000, and k+n≧1.

[0014] R 1 From the viewpoint of significantly achieving the effects of the present invention, the hydrocarbon group is preferably an alkyl or alkylene group having 2 to 12 carbon atoms, more preferably an alkyl or alkylene group having 2 to 4 carbon atoms, and even more preferably an ethyl group having 2 carbon atoms.

[0015] R 2 and R 4 each independently represents an alkylene group having 2 to 4 carbon atoms, and from the viewpoint of significantly achieving the effects of the present invention, is preferably an alkylene group having 2 carbon atoms (ethylene group).

[0016] R 3 is a linear, branched, or h+1-valent hydrocarbon group containing an aliphatic ring or aromatic ring, which may have a urethane bond. Among these, a linear hydrocarbon group is preferred from the viewpoint of significantly achieving the effects of the present invention.

[0017] R 3 The number of carbon atoms is preferably 1 to 10, and more preferably 2 to 8, from the viewpoint of significantly exhibiting the effects of the present invention. R 3 A preferred example of the hydrocarbon group is a hexamethylene group.

[0018] R 5 is a branched hydrocarbon group, and the number of carbon atoms is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 8 to 36, more preferably 10 to 30, and even more preferably 12 to 24. R 5A preferred example of the hydrocarbon group is a 2-dodecyldodecyl group.

[0019] The value of m is an integer of 2 or more, and is preferably 2.

[0020] The value of h is 1 or more, and preferably 1, from the viewpoint of achieving a remarkable effect of the present invention.

[0021] k, which is the number of repetitions of O-R2, and n, which is the number of repetitions of R4-O, are each independently 0 to 1000, and both k and n cannot be 0. That is, k+n is 1 or more.

[0022] The value of k is preferably 1 to 500, more preferably 10 to 400, even more preferably 50 to 300, and even more preferably 100 to 300, from the viewpoint of significantly exhibiting the effects of the present invention.

[0023] The value of n is preferably 1 to 200, more preferably 5 to 200, and further preferably 10 to 100, from the viewpoint of significantly exhibiting the effects of the present invention.

[0024] From the viewpoint of significantly exhibiting the effects of the present invention, the hydrophobically modified polyether urethane used in the present invention is preferably one or more selected from the group consisting of (PEG-240 / decyltetradeceth-20 / HDI) copolymers (ADEKA NOL GT-700, ADEKA NOL GT-730: manufactured by ADEKA CORPORATION) and steareth-100 / PEG-136 / HDI copolymer (RHEOLUXE 811: manufactured by Elementis Japan Co., Ltd.), and more preferably is (PEG-240 / decyltetradeceth-20 / HDI) copolymer.

[0025] The total content of component (A) is not particularly limited and is set appropriately depending on the type of water-soluble polysaccharide, the types of other blended ingredients, etc., but from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.1 mass% or more, more preferably 0.2 mass% or more, even more preferably 0.5 mass% or more, and even more preferably 1 mass% or more, based on the total amount of the topical skin composition. The total content of component (A) is preferably 6% by mass or less, more preferably 5% by mass or less, even more preferably 4.5% by mass or less, and even more preferably 4% by mass or less, based on the total amount of the composition for external use on skin. The total content of component (A) is preferably 0.1 to 6 mass%, more preferably 0.2 to 5 mass%, even more preferably 0.5 to 4.5 mass%, and even more preferably 1 to 4 mass%, based on the total amount of the composition for external use on skin.

[0026] [(B) Component] As component (B) of the skin topical composition of the present invention, one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids are used. Among them, the skin topical composition of the present invention more preferably contains one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, and tranexamic acids, even more preferably one or more components selected from the group consisting of nicotinamide and vitamin C derivatives, and even more preferably nicotinamide.

[0027] In the present specification, the salt is a pharma- ceutically acceptable salt. Examples of the salt include, but are not limited to, salts with organic bases (e.g., salts with tertiary amines such as trimethylamine salts, triethylamine salts, monoethanolamine salts, triethanolamine salts, pyridine salts, and the like, basic ammonium salts such as arginine, and the like), salts with inorganic bases (e.g., alkali metal salts such as ammonium salts, sodium salts, and potassium salts, alkaline earth metal salts such as calcium salts and magnesium salts, zinc salts, aluminum salts, and the like), salts with inorganic acids (hydrochlorides, sulfates, nitrates, hydrobromides, phosphates, and the like), salts with organic acids (acetates, butyrates, fumarates, maleates, and the like), and the like. Among them, preferred salts are triethanolamine salts, sodium salts, potassium salts, magnesium salts, and zinc salts, and more preferred salts are sodium salts, potassium salts, and magnesium salts.

[0028] Nicotinamide is an amide compound of nicotinic acid (vitamin B3 / niacin) and is a water-soluble vitamin. Nicotinamide may be an extract from a natural product or may be synthesized by a known method. Specifically, those listed in the 17th revised Japanese Pharmacopoeia can be used. It is known to have blood circulation promoting effects, skin roughness improving effects, melanin production suppressing effects, and whitening effects.

[0029] Vitamin C derivatives are compounds obtained by replacing part of ascorbic acid with other atoms or substituents, or stereoisomers of ascorbic acid, or salts thereof. Examples of vitamin C derivatives include dehydroascorbic acid; ascorbic acid alkyl esters such as 3-O-ethyl ascorbic acid (VC ethyl), 2-O-ethyl ascorbic acid, and 3-O-cetyl ascorbic acid; acyl ascorbic acids such as ascorbyl tetraisopalmitate (ascorbyl tetra 2-hexyldecanoate), ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl stearate, L-ascorbyl dioleate, L-ascorbyl tristearate, ascorbyl tripalmitate, and ascorbyl trioleate; ascorbyl glycerin esters such as glyceryl ascorbate, bisglyceryl ascorbate, and alkylglyceryl ascorbate; ascorbic acid glycosides such as ascorbic acid glucoside (VC glucoside) (ascorbic acid-2-glucoside (AA2G)); Examples of the ascorbic acid monophosphate esters include ascorbic acid monophosphate esters such as ascorbyl phosphate, magnesium ascorbyl phosphate (magnesium L-ascorbyl phosphate), sodium ascorbyl phosphate, isostearyl ascorbyl phosphate, palmitic acid ascorbyl phosphate, ascorbic acid diphosphate esters, ascorbic acid triphosphate esters, ascorbic acid sulfate esters, ascorbyl / tocopheryl (ascorbyl / tocopheryl) phosphate, ascorbyl maleate tocopherol derivatives, ascorbyl silicones such as methylsilanol ascorbate, and salts thereof, but are preferably one or more selected from the group consisting of ascorbic acid alkyl esters, ascorbic acid monophosphate esters, L-ascorbic acid glucoside, ascorbyl tocopherol derivatives, ascorbyl glycerol esters, and salts thereof. More preferably, are one or more selected from the group consisting of ascorbic acid alkyl esters, ascorbic acid monophosphate esters, L-ascorbic acid glucoside, ascorbyl tocopherol derivatives, and salts thereof.

[0030] Examples of vitamin C derivatives preferred as component (B) of the present invention include ascorbyl tetraisopalmitate, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, disodium ascorbyl sulfate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid-2-glucoside, disodium isostearyl ascorbyl phosphate, trisodium ascorbyl palmitate phosphate; glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-laurylglyceryl ascorbic acid, (ascorbyl / tocopheryl) phosphate, potassium (ascorbyl / tocopheryl) phosphate, and ascorbyl tocopheryl maleate.Preferably, the ester is one or more selected from the group consisting of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid; ascorbic acid-2-glucoside, disodium isostearyl ascorbyl phosphate, trisodium palmitate ascorbyl phosphate, 3-glyceryl ascorbic acid, bisglyceryl ascorbic acid, hexyl 3-glyceryl ascorbic acid, 3-glyceryl ascorbic acid, myristyl 3-glyceryl ascorbic acid, 3-lauryl glyceryl ascorbic acid, potassium (ascorbyl / tocopheryl) phosphate, and ascorbyl tocopheryl maleate, and more preferably, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, 2-O-ethyl ascorbic acid, Ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid 2-glucoside, disodium isostearyl ascorbyl phosphate, trisodium ascorbyl palmitate phosphate, and potassium (ascorbyl / tocopheryl) phosphate are preferably at least one selected from the group consisting of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, and ascorbic acid 2-glucoside, more preferably at least one selected from the group consisting of magnesium ascorbyl phosphate, 3-O-ethyl ascorbic acid, and ascorbic acid 2-glucoside, and particularly preferably 3-O-ethyl ascorbic acid.

[0031] Arbutin is obtained by binding glucose to hydroquinone, and the one in which the bond between hydroquinone and glucose is an α-bond is called α-arbutin, and the one in which the bond between hydroquinone and glucose is a β-bond is called β-arbutin. As the component (B) of the present invention, either α-arbutin or β-arbutin can be suitably used, but β-arbutin is more preferred.

[0032] Tranexamic acids include tranexamic acid, derivatives of tranexamic acid, and salts thereof. Tranexamic acid is a compound also called trans-4-(aminomethyl)cyclohexane-1-carboxylic acid, and may be synthesized by a known method or may be available as a commercial product. The derivatives of tranexamic acid are not particularly limited as long as they are pharmacologically or physiologically acceptable, and examples thereof include dimers of tranexamic acid; amides of tranexamic acid such as methyl amide tranexamic acid and ethyl amide tranexamic acid; hydroquinone esters of tranexamic acid; vitamin esters of tranexamic acid such as vitamin A ester, vitamin E ester, and vitamin C ester; gentisic acid ester of tranexamic acid; cetyl tranexamate; and tranexamic acid ester derivatives such as salts thereof. These derivatives of tranexamic acid may be synthesized by a known method or may be available as a commercial product. Among them, tranexamic acid is preferable as the component (B) of the present invention.

[0033] In the topical skin composition of the present invention, the total content of component (B) relative to the total amount of the topical skin composition is appropriately set depending on the balance with other components, but from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.5% by mass or more, and even more preferably 1% by mass or more. The total content of component (B) is preferably 10% by mass or less, more preferably 8% by mass or less, even more preferably 6% by mass or less, and particularly preferably 5% by mass or less, based on the total amount of the composition for external use on skin. The content of component (B) is preferably 0.01 to 20 mass%, more preferably 0.01 to 10 mass%, even more preferably 0.1 to 8 mass%, even more preferably 0.5 to 6 mass%, and particularly preferably 1 to 5 mass%, based on the total amount of the topical skin composition.

[0034] When nicotinamide is contained as component (B), the content of nicotinamide is preferably 1.5 to 20 mass%, more preferably 2 to 15 mass%, even more preferably 3 to 10 mass%, and even more preferably 3 to 8 mass%, based on the total amount of the topical skin composition.

[0035] When a vitamin C derivative and its salt are contained as component (B), the content of the vitamin C derivative and its salt is preferably 0.01 to 10 mass%, more preferably 0.5 to 8 mass%, even more preferably 1 to 5 mass%, and even more preferably 1 to 3 mass%, based on the total amount of the topical skin composition.

[0036] When arbutin is contained as component (B), the content of arbutin is preferably 0.01 to 5 mass%, more preferably 0.1 to 4.8 mass%, even more preferably 0.5 to 4.5 mass%, even more preferably 0.5 to 4 mass%, and particularly preferably 1 to 3 mass%, relative to the total amount of the topical skin composition.

[0037] When tranexamic acids are contained as component (B), the content of the tranexamic acids is preferably 0.01 to 10 mass%, more preferably 0.5 to 8 mass%, even more preferably 0.5 to 5 mass%, even more preferably 1 to 3 mass%, and particularly preferably 1.2 to 3 mass%, relative to the total amount of the topical skin composition.

[0038] The total content of the (B) component per 1 part by mass of the total content of the (A) component in the topical skin composition of the present invention is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.0002 to 10,000 parts by mass, more preferably 0.001 to 8,000 parts by mass, even more preferably 0.01 to 5,000 parts by mass, even more preferably 0.1 to 1,000 parts by mass, and particularly preferably 0.5 to 500 parts by mass.

[0039] [(C) component] In order to further enhance the effects of the present invention, the topical skin composition of the present invention further contains, in addition to components (A) and (B), one or more components selected from the group consisting of phenoxyethanol, dipropylene glycol, and amphiphilic components as component (C).

[0040] An amphiphilic component generally refers to a compound that has both hydrophilic and hydrophobic groups (lipophilic groups) in one molecule, and therefore has affinity for both the aqueous phase and the oil phase (organic phase).

[0041] Such amphiphilic components are not particularly limited, but examples thereof include alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-containing polymers, divalent carboxylic acid esters, alkanediols having 5 to 10 carbon atoms, etc. As the component (C) of the present invention, any of these compounds can be used alone, or two or more of them can be used in combination.

[0042] The component (C) is preferably one or more selected from the group consisting of phenoxyethanol, an alkylene oxide derivative represented by the following general formula (II), 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, (eicosadioic acid / tetradecanedioic acid) decaglyceryl, bisethoxydiglycol cyclohexanedicarboxylate, diethylhexyl succinate, diethoxyethyl succinate, and alkanediols having 5 to 10 carbon atoms.

[0043] The alkylene oxide derivative used in the present invention is represented by the following formula (II).

[0044] Z-[O-(AO) a (EO) b -(BO) c -H] n (II) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively, and are each independently 0 to 200; a, b, and c are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different, When Z is a hydrogen atom, n is 1.

[0045] The alkylene oxide derivative may be a compound represented by the following general formula (III).

[0046] Z-[O-(AO) a (EO) b -H] n (III) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; a and b are the average number of moles of AO, EO, and BO added, respectively, and are each independently 0 to 200; a and b are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's and b's may be the same or different, When Z is a hydrogen atom, n is 1.

[0047] In the chemical formulas (II) and (III), Z is, from the viewpoint of significantly exhibiting the effects of the present invention, preferably a hydrogen atom or a group obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, trimethylolpropane, erythritol, pentaerythritol, an alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sorbitol, inositol, sucrose, trehalose, maltitol, or a hydroxy compound having 1 to 30 carbon atoms, and more preferably a hydrogen atom or a hydroxy compound having 4 to 24 carbon atoms. is preferably a group obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms, pentaerythritol, alkyl glucoside, glycerin, diglycerin, or sorbitol, more preferably a group obtained by removing n hydroxy groups from a hydrogen atom, an alkyl monoalcohol having 4 to 24 carbon atoms, alkyl glucoside, diglycerin, or glycerin, and even more preferably a group obtained by removing n hydroxy groups from a hydrogen atom, an alkyl monoalcohol having 4 to 24 carbon atoms, diglycerin, or glycerin.

[0048] In the chemical formulas (II) and (III), when Z is an alkyl monoalcohol having 4 to 24 carbon atoms, from the viewpoint of significantly exhibiting the effects of the present invention, butyl alcohol, tetradecyl tetraalcohol, cetanol, or stearyl alcohol is preferable, and butyl alcohol is more preferable.

[0049] In the chemical formulas (II) and (III), when Z is an alkyl glucoside, from the viewpoint of significantly exhibiting the effects of the present invention, an alkyl glucoside in which the alkyl group portion has 1 to 24 carbon atoms is preferable, an alkyl glucoside in which the alkyl group portion has 1 to 16 carbon atoms is more preferable, an alkyl glucoside in which the alkyl group portion has 1 to 10 carbon atoms is even more preferable, and an alkyl glucoside in which the alkyl group portion has 1 to 5 carbon atoms is particularly preferable.

[0050] In the chemical formulas (II) and (III), AO is an oxyalkylene group having 3 to 4 carbon atoms, and examples thereof include an oxypropylene group, an oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), an oxytrimethylene group, an oxytetramethylene group, etc. AO is preferably an oxypropylene group or an oxybutylene group, and more preferably an oxypropylene group. BO is an oxyalkylene group having 4 carbon atoms, examples of which include an oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), an oxytetramethylene group, etc. An oxybutylene group is preferred.

[0051] In the alkylene oxide derivative used in the present invention, a, b, and c are each independently 0 to 200. a, b, and c are each independently preferably 1 to 200, more preferably 2 to 150, even more preferably 2 to 100, and particularly preferably 2 to 70.

[0052] In chemical formula (II), a+b+c, which is the total number of AO, EO, and BO monomer units, is, from the viewpoint of significantly exhibiting the effects of the present invention, preferably 3 or more, more preferably 5 or more, even more preferably 10 or more, and is preferably 450 or less, more preferably 350 or less, even more preferably 300 or less, and particularly preferably 250 or less.

[0053] In the chemical formulae (II) and (III), from the viewpoint of significantly achieving the effects of the present invention, the total number of AO and EO monomer units, a+b, is preferably 3 or more, more preferably 5 or more, and even more preferably 10 or more. In addition, from the viewpoint of significantly achieving the effects of the present invention, a+b is preferably 400 or less, more preferably 300 or less, even more preferably 250 or less, and particularly preferably 200 or less.

[0054] The molecular weight of the alkylene oxide derivative used in the present invention is preferably 120 or more, more preferably 200 or more, further preferably 300 or more, and particularly preferably 400 or more, from the viewpoint of significantly exhibiting the effects of the present invention. The molecular weight of the alkylene oxide derivative is preferably 50,000 or less, more preferably 10,000 or less, and even more preferably 5,000 or less.

[0055] The properties of the alkylene oxide derivatives of the formulas (II) and (III) are not limited as long as they achieve the effects of the present invention. From the viewpoint of achieving the effects of the present invention remarkably, however, they are preferably components that are semi-solid (including paste-like) to liquid at 25°C.

[0056] Examples of such alkylene oxide derivatives include polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyalkylene sorbitol, polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyalkylene xylitol, polyoxyalkylene dipentaerythritol, polyoxyalkylene inositol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose ether, and polyoxyalkylene maltitol ether. Among these, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbitol, polyoxyethylene sorbitol, polyoxypropylene erythritol ether, polyoxyethylene pentane, polyoxyethylene glyceryl ether ... erythritol ether, polyoxyethylene polyoxypropylene erythritol ether, polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxyethylene trimethylolpropane, polyoxypropylene trimethylolpropane, polyoxyethylene polyoxypropylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxybutylene polyoxyethylene polyoxypropylene glycol,Preferred are one or more selected from the group consisting of polyoxyethylene xylitol, polyoxypropylene alkylene xylitol, polyoxyethylene polyoxypropylene xylitol, polyoxyethylene polyoxypropylene dipentaerythritol, polyoxyethylene dipentaerythritol, polyoxypropylene dipentaerythritol, polyoxyethylene inositol, polyoxypropylene inositol, polyoxyethylene polyoxypropylene inositol, polyoxyethylene sucrose ether, polyoxypropylene sucrose ether, polyoxyethylene polyoxypropylene sucrose ether, polyoxyethylene trehalose ether, polyoxypropylene trehalose ether, polyoxyethylene polyoxypropylene trehalose ether, polyoxyethylene maltitol ether, polyoxypropylene maltitol ether, and polyoxyethylene polyoxypropylene ether, More preferably, one or more selected from the group consisting of polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbitol, polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol, More preferably, the polyoxyethylene glyceryl ether is one or more selected from the group consisting of polyoxyethylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxybutylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol and polyoxyethylene polyoxypropylene alkyl ether, Even more preferred is one or more selected from the group consisting of polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside, polyoxypropylene methyl glucoside, polyoxyethylene methyl glucoside, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxybutylene polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene butyl ether, and polyoxyethylene polyoxypropylene decyl tetradecyl ether.

[0057] Such alkylene oxide derivatives are commercially available products, and are not particularly limited. Examples of such alkylene oxide derivatives include WILBRIDE S-753 (polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O.) (8E.O.) (5P.O.)), WILBRIDE MG2070 (polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside), MacBiobride MG-10E (polyoxyethylene methyl glucoside (10E.O.)), MacBiobride MG-20E (polyoxyethylene methyl glucoside (20E.O.)), MacBiobride MG-20P (polyoxyethylene methyl glucoside (20P.O.)), MacBiobride MG-10P, Unilube 5TP-300KB (polyoxyethylene polyoxypropylene methyl glucoside (20P.O.)), Pentaerythritol ether (5E.O.) (65P.O.)), Unilube 50MB-26 (Polyoxyethylene polyoxypropylene butyl ether (17E.O.) (17P.O.)), Unilube 50MB-168 (Polyoxyethylene polyoxypropylene butyl ether (37E.O.) (38P.O.)), Unilube 50MB-11 (Polyoxyethylene polyoxypropylene butyl ether (9E.O.) (10P.O.)), Unisafe 10P-8 (Polyoxy Ethylene polyoxypropylene cetyl ether (10 E.O.) (8 P.O.)), Unilube MT-630B (Polyoxyethylene polyoxypropylene decyl tetradecyl ether (30 E.O.) (6 P.O.)), Sorbure GS-01 (Polyoxyethylene polyoxypropylene decyl tetradecyl ether (24 E.O.) (13 P.O.)), Unilube MS-70K (Polyoxypropylene stearyl ether (15 P.O.)), Uniol HS-1600D (Poly Oxypropylene sorbitol (25 P.O.)), Pronon #208 (Polyoxyethylene polyoxypropylene glycol (150 E.O.) (35 P.O.)), Uniol D-2000 (Polypropylene glycol (34 P.O.)), Uniox G-1200 (Polyoxyethylene glycerin (26 E.O.)), Uniol TG-3000 (Polyoxypropylene glycerin (50 P.O.)), Unilube DGP-700 (Polyoxypropylene diglyceryl ether (9 P.O.), Unilube DGP-950 (polyoxypropylene diglyceryl ether (14P.O.)) (all manufactured by NOF Corp.); SY-DP14T (polyoxypropylene diglyceryl ether (14P.O.)), SY-DP9 (polyoxypropylene diglyceryl ether (9P.O.)), SY-DP14T (polyoxypropylene diglyceryl ether (14P.O.)) (all manufactured by Sakamoto Pharmaceutical Co., Ltd.); Brownon GL-26, (polyoxyethylene glycerin (26E.O.)) (all manufactured by Aoki Oil Co., Ltd.), Newpol GP-1000 (polyoxypropylene diglyceryl ether (14P.O.)) (all manufactured by Aoki Oil Co., Ltd.) propylene glyceryl ether (16 P.O.)), Newpol SP-750 (polyoxypropylene sorbitol (10 P.O.)), Newpol PE-68 (polyoxyethylene polyoxypropylene glycol (160 E.O.) (30 P.O.)), Newpol PE-78 (polyoxyethylene polyoxypropylene glycol (150 E.O.) (35 P.O.)), Newpol GEP-2800 (polyoxyethylene polyoxypropylene glyceryl ether (24 E.O.) (24 P.O.) (all manufactured by Sanyo Chemical Industries, Ltd.); NIKKOL SG-G2424 (Polyoxyethylene polyoxypropylene glyceryl ether (24E.O.) (24P.O.), NIKKOL SG-DTD630 (Polyoxyethylene polyoxypropylene decyl tetradecyl ether (30E.O.) (6P.O.), NIKKOL SG-DTD620 (Polyoxyethylene polyoxypropylene decyl tetradecyl ether (20E.O.) (6P.O.)), NIKKOL PEN-4612 (Polyoxyethylene polyoxypropylene decyl tetradecyl ether (12E.O.) (6P.O.)) (all manufactured by Nikko Chemicals); GLUCAM P-10 (Polyoxypropylene methyl glucoside (10P.O.)), GLUCAM P-20 (Polyoxypropylene methyl glucoside (20P.O.)) GLUCAM Examples of suitable glycerols that can be used include E-10 (polyoxyethylene methyl glucoside (10 P.O.)) and GLUCAM E-20 (polyoxyethylene methyl glucoside (20 P.O.)) (both manufactured by Lubrizol Corporation).

[0058] Commercially available alkylene oxide derivatives that can remarkably exhibit the effects of the present invention include Unilube 50MB-26, Unilube 50MB-168, Uniol HS-1600D, Pronon #208, Pronon #124P, Uniol D-2000, Macbiobride MG-10E, Macbiobride MG-20E, Macbiobride MG-10P, Macbiobride MG-20P, WILBRIDE MG2070, Unilube 5TP-300KB, Unilube 50TG-32, WILBRIDE S-753, Uniox G-1200, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, Newpol GP-1000, Newpol SP-750, Newpol PE-68, Newpol PE-78, Newpol GEP-2800, and NIKKOL It is preferable that the pigment is one or more selected from the group consisting of SG-G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN-4612, NIKKOL SG-DTD620, NIKKOL SG-DTD630, Unilube MT-630B, Sorbure GS-01, GLUCAM E-20 and Emulgen PP-290, Unilube 50MB-26, Unilube 50MB-168, Uniol HS-1600D, Pronon #208, Pronon #124P, Uniol D-2000, Macbiobride MG-10E, Macbiobride MG-20E, Macbiobride MG-10P, Macbiobride MG-20P, WILBRIDE MG2070, WILBRIDE S-753, Uniox G-1200, Unilube 50TG-32, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, Newpol GP-1000, Newpol SP-750, Newpol PE-68, Newpol PE-78, Newpol GEP-2800, NIKKOL SG-G2424, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN-4612, NIKKOL SG-DTD620, NIKKOL SG-DTD630, Unilube MT-630B, Sorbure GS-01, GLUCAM E-20 and Emulgen PP-290 are more preferable, More preferably, the adhesive is one or more selected from the group consisting of UNILUBE 50MB-26, UNILUBE 50MB-168, WILBRIDE S-753, WILBRIDE MG2070, MacBioBride MG-20P, MacBioBride MG-10P, MacBioBride MG-20E, MacBioBride MG-10E, UNILUBE DGP-700, UNILUBE DGP-950, SY-DP14, SY-DP9, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, NIKKOL PEN-4612, NIKKOL SG-DTD620, NIKKOL SG-DTD630, UNILUBE MT-630B, Sorbure GS-01 and GLUCAM E-20, It is even more preferable that the compound is one or more selected from the group consisting of Unilube 50MB-26, Unilube 50MB-168, WILBRIDE S-753, WILBRIDE MG2070, MacBiobride MG-20P, MacBiobride MG-10P, MacBiobride MG-20E, MacBiobride MG-10E, Unilube DGP-700, Unilube DGP-950, GLUCAM P-10, GLUCAM P-20, GLUCAM E-10, SY-DP14, and SY-DP9.

[0059] The 2-methacryloyloxyethyl phosphorylcholine-containing polymer is a polymer obtained by polymerizing a monomer containing 2-methacryloyloxyethyl phosphorylcholine. From the viewpoint of significantly exhibiting the effects of the present invention, the 2-methacryloyloxyethyl phosphorylcholine-containing polymer used in the present invention is preferably one or more selected from the group consisting of Lipidure-PMB (2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer liquid, Polyquaternium-51) and Lipidure-HM (polymethacryloyloxyethyl phosphorylcholine) (both manufactured by NOF Corporation), and more preferably Lipidure-PMB.

[0060] The dicarboxylic acid ester is a compound obtained by condensing a dicarboxylic acid with a hydroxy group such as glycol or glycol ether, and is not particularly limited. Examples of the dicarboxylic acid ester include, but are not limited to, decaglyceryl (eicosane diacid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylate, bis(triethylene glycol monoethyl ether) 1,4-cyclohexanedicarboxylate, bis(diethylene glycol monoethyl ether) adipate, bis(triethylene glycol monoethyl ether) adipate, and diethoxyethyl succinate. and diethylhexyl succinate. Among them, one or more selected from the group consisting of decaglyceryl (eicosane diacid / tetradecanedioate), bis-ethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, and diethylhexyl succinate are preferred, one or two selected from the group consisting of decaglyceryl (eicosane diacid / tetradecanedioate) and bis-ethoxydiglycol cyclohexanedicarboxylate are more preferred, and bis-ethoxydiglycol cyclohexanedicarboxylate is even more preferred. In addition, commercially available products that can be used include, but are not limited to, diethoxyethyl succinate (CRODAMOL DES), diethylhexyl succinate (CRODAMOL OSU) (both manufactured by Croda Japan Ltd.), Neosolue-Aqua / Neosolue-AquaS (decaglyceryl (eicosandioate / tetradecanedioate)), Neosolue-Aqulio (bisethoxydiglycol cyclohexanedicarboxylate) (all manufactured by Nippon Fine Chemicals Co., Ltd.), and the like.

[0061] From the viewpoint of significantly achieving the effects of the present invention, the alkanediol has a carbon number of preferably 5 to 10, more preferably 5 to 8, and even more preferably 5 to 6. For example, one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol are preferred, one or two selected from the group consisting of 1,2-pentanediol and 1,2-hexanediol are more preferred, and 1,2-pentanediol is even more preferred. In addition, examples of commercially available products that can be used include, but are not limited to, HYDROLITE-5, HYDROLITE-5 Green (manufactured by Symrise Co., Ltd.), KMO-6 (manufactured by Osaka Organic Chemical Industry Co., Ltd.), Microcare Emollient PTGJ, Microcare Emollient HXD (manufactured by THOR Co., Ltd.), Diol PD, Diol PD-V (manufactured by Kokyu Alcohol Industry Co., Ltd.), CleanBio-HD (manufactured by Kolon Life Science, Inc.), and Lexgard (registered trademark) H (manufactured by Inolex Chemical Company).

[0062] When component (B) is a vitamin C derivative, component (C) is preferably one or more selected from the group consisting of phenoxyethanol, alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-containing polymers, dicarboxylic acid esters, and alkanediols having 5 to 10 carbon atoms, more preferably one or more selected from the group consisting of alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymers, dicarboxylic acid esters, and alkanediols having 5 to 10 carbon atoms, and even more preferably one or more selected from the group consisting of alkylene oxide derivatives of formula (II) in which Z is a group obtained by removing n hydroxy groups from an alkyl monoalcohol having 4 to 24 carbon atoms or glycerin, dicarboxylic acid esters, and alkanediols having 5 to 10 carbon atoms. When component (B) is arbutin, component (C) is preferably one or more selected from the group consisting of dipropylene glycol, alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-containing polymers, dicarboxylic acid esters, and alkanediols having 5 to 10 carbon atoms, and more preferably one or more selected from the group consisting of alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymers, dicarboxylic acid esters, and alkanediols having 5 to 10 carbon atoms. When component (B) is a tranexamic acid, component (C) is preferably one or more selected from the group consisting of dipropylene glycol, alkylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine-containing polymers, dicarboxylic acid esters, and alkanediols having 5 to 10 carbon atoms, and more preferably one or more selected from the group consisting of dicarboxylic acid esters and alkanediols having 5 to 10 carbon atoms.

[0063] The total content of component (C) is not particularly limited and is set appropriately depending on the type of water-soluble polysaccharide, the types of other blended ingredients, etc., but from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.001 mass% or more, more preferably 0.01 mass% or more, even more preferably 0.1 mass% or more, still more preferably 0.3 mass% or more, and particularly preferably 0.5 mass% or more, based on the total amount of the topical skin composition. The total content of component (C) is preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 15% by mass or less, and even more preferably 10% by mass or less, based on the total amount of the topical skin composition. The total content of component (C) is preferably 0.001 to 30 mass%, more preferably 0.01 to 20 mass%, even more preferably 0.1 to 15 mass%, even more preferably 0.3 to 10 mass%, and particularly preferably 0.5 to 10 mass%, based on the total amount of the topical skin composition.

[0064] Of the components (C), the content of phenoxyethanol is not particularly limited, and from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.001 to 5 mass%, more preferably 0.01 to 3 mass%, even more preferably 0.05 to 2 mass%, and even more preferably 0.1 to 1 mass%, relative to the total amount of the topical skin composition. Of the components (C), the content of dipropylene glycol is not particularly limited, and from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.01 to 20 mass%, more preferably 0.1 to 15 mass%, even more preferably 0.5 to 12 mass%, and even more preferably 1 to 10 mass%, relative to the total amount of the topical skin composition. The content of the amphiphilic component in component (C) is not particularly limited, and from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.001 to 20 mass% relative to the total amount of the topical skin composition, more preferably 0.01 to 15 mass%, even more preferably 0.1 to 10 mass%, and even more preferably 0.5 to 8 mass%. Among the amphiphilic components of component (C), the content of the divalent carboxylic acid ester and / or alkylene oxide derivative is not particularly limited, and from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.01 to 20 mass%, more preferably 0.1 to 15 mass%, even more preferably 0.5 to 10 mass%, and even more preferably 0.5 to 8 mass%, relative to the total amount of the topical skin composition. Of the amphiphilic components of component (C), the content of the 2-methacryloyloxyethyl phosphorylcholine-containing polymer is not particularly limited, and from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.001 to 1 mass%, more preferably 0.005 to 0.5 mass%, even more preferably 0.01 to 0.4 mass%, and even more preferably 0.01 to 0.2 mass%, relative to the total amount of the topical skin composition. Among the amphiphilic components of component (C), the content of the alkanediol having 5 to 10 carbon atoms is not particularly limited, and from the viewpoint of significantly achieving the effects of the present invention, it is preferably 0.01 to 20 mass%, more preferably 0.05 to 15 mass%, even more preferably 0.1 to 12 mass%, even more preferably 0.5 to 10 mass%, particularly preferably 1 to 10 mass%, and especially preferably 1 to 5 mass%, relative to the total amount of the topical skin composition.

[0065] The total content of the (C) component per 1 part by mass of the total content of the (B) component in the topical skin composition of the present invention is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.0005 to 3000 parts by mass, more preferably 0.002 to 200 parts by mass, even more preferably 0.01 to 100 parts by mass, even more preferably 0.02 to 30 parts by mass, and particularly preferably 0.1 to 10% by mass.

[0066] [Other ingredients] In addition to the above-mentioned components (A) to (C), the skin topical composition of the present invention may contain one or more of various components, such as an ultraviolet scattering agent, an ultraviolet absorbing agent, a component having a preventive and / or repairing effect on DNA damage, a whitening component, an anti-inflammatory component, an antibacterial component, a bactericidal component, a refreshing agent, an organic acid, an anti-glycation component, a cell activating component, an astringent component, an antioxidant component, an anti-aging component, a moisturizing component, a polyhydric alcohol, a keratin softening component, vitamins, a blood circulation promoting component, a sebum adsorbing component, a peptide or a derivative thereof, and an amino acid or a derivative thereof, in order to impart other useful effects. Each of these components is not particularly limited as long as it can be used in the fields of medicines, quasi-drugs, cosmetics, etc., and any one can be appropriately selected and used. In addition, components that fall under the following multiple components can be added as components with any of the effects.

[0067] Examples of the ultraviolet scattering agent include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, and hydrous silicic acid, and inorganic compounds coated with hydrous silicic acid, aluminum hydroxide, mica, talc, and other inorganic powders, or composites with resin powders such as polyamide, polyethylene, polyester, polystyrene, and nylon, and further treated with silicone oil, fatty acid aluminum salt, alkyl titanate, and the like. Among them, inorganic compounds such as zinc oxide, titanium oxide, and iron oxide, and inorganic compounds coated with aluminum hydroxide, hydrous silicic acid, mica, talc, and other inorganic powders or silicone oil are preferred. When an ultraviolet scattering component is incorporated, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.001 to 35% by mass, preferably about 0.1 to 25% by mass, based on the total amount of the skin external composition of the present invention.

[0068] The ultraviolet absorber is not limited, but may preferably be a salicylic acid-based ultraviolet absorber, a cinnamic acid-based ultraviolet absorber, a benzoylmethane-based ultraviolet absorber, a benzoic acid ester derivative ultraviolet absorber, a triazine derivative ultraviolet absorber, a benzalmalonate derivative ultraviolet absorber, an octocrylene-based ultraviolet absorber, an imidazole sulfonic acid derivative ultraviolet absorber, a benzophenone derivative ultraviolet absorber, or the like.

[0069] Examples of the ultraviolet absorber include salicylic acid-based ultraviolet absorbers such as 2-ethylhexyl salicylate, homomenthyl salicylate, and ethylene glycol salicylate; cinnamic acid-based ultraviolet absorbers such as di-paramethoxycinnamate mono-2-ethylhexanoate glyceryl; paramethoxycinnamate 2-ethylhexyl; benzoylmethane-based ultraviolet absorbers such as 4-tert-butyl-4'-methoxydibenzoylmethane; 2-[4-(diethylamino) -2-Hydroxybenzoyl]benzoic acid hexyl ester and other benzoic acid ester derivatives UV absorbers;Dimethoxybenzylidene dioxoimidazolidinepropionic acid 2-ethylhexyl;2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol];2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl) benzalmalonate derivative ultraviolet absorbers such as dimethicodiethyl benzalmalonate; octocrylene ultraviolet absorbers such as 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester; imidazole sulfonic acid derivative ultraviolet absorbers such as 2-phenylbenzimidazole-5-sulfonic acid and phenyldibenzimidazole tetrasulfonic acid disodium; and benzophenone derivative ultraviolet absorbers such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone.

[0070] In the present invention, such ultraviolet absorbers include, but are not limited to, 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol] ...4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, Preferred is one or more selected from the group consisting of 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, dimethicodiethylbenzalmalonate, 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester, and 2-phenylbenzimidazole-5-sulfonic acid.

[0071] The ultraviolet absorbing agent may be a commercially available product or may be synthesized.

[0072] Commercially available products include, but are not limited to, Parsol EHS (DSM Nutrition Japan), ESCALOL 587 (Ashland Japan), EusolexOS (Merk), Parsol HMS (DSM Nutrition Japan), Uvinul MC80 (BASF), Parsol MCX (DSM Nutrition Japan), Parsol 1789 (DSM Nutrition Japan), Uvinul A Plus Granular, Soft Shade DH, Tinosorb M (BASF), Milestab 360, Mixxim BB / 100, Tinosorb S (BASF), Uvasorb HEB, Uvinul T150 (BASF), Heliosun OTZ (O'Laughlin Industries), Parsol SLX (DSM Nutrition Japan), Parsol 340 (manufactured by DSM Nutrition Japan), Escarol 597 (manufactured by Ashland Japan), Parsol HS (manufactured by DSM Nutrition Japan), Eusolex 232 (manufactured by Merk), NeoHeliopan AP (manufactured by Herman & Reimer), Ubinal M40, Escarol 567 (manufactured by Ashland Japan), Ubinal MS40 (manufactured by BASF), SEESORB 107 (manufactured by Cipro Chemicals), SEESORB 100 (manufactured by Cipro Chemicals), and SEESORB 106 (manufactured by Cipro Chemicals).

[0073] In the skin external composition of the present invention, the total content of the ultraviolet absorbent is preferably 1% by mass or more, more preferably 3% by mass or more, even more preferably 6% by mass or more, and even more preferably 7% by mass or more, based on the total amount of the composition. The total content of the ultraviolet absorbent is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less, based on the total amount of the composition. The total content of the ultraviolet absorbent is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, even more preferably 5 to 10% by mass, and even more preferably 7 to 10% by mass, based on the total amount of the composition.

[0074] In the topical skin composition of the present invention, the ratio of the total content of the ultraviolet absorber to the component (B) is not particularly limited, but the ultraviolet absorber is preferably 0.1 to 20 parts by mass, more preferably 0.1 to 15 parts by mass, even more preferably 0.1 to 10 parts by mass, even more preferably 0.1 to 6 parts by mass, particularly preferably 0.5 to 4 parts by mass, and especially preferably 1 to 2 parts by mass, per 1 part by mass of the component (B). In the topical skin composition of the present invention, when component (B) is one or more selected from the group consisting of vitamin C derivatives and tranexamic acids, the ratio of the total content of ultraviolet absorbers to component (B) is not particularly limited, but is preferably 0.5 to 20 parts by mass, more preferably 1 to 18 parts by mass, even more preferably 2 to 15 parts by mass, and even more preferably 5 to 10 parts by mass of ultraviolet absorbers per part by mass of component (B).

[0075] Furthermore, these ultraviolet scattering agents and ultraviolet absorbing agents may be complexed with, supported on, or encapsulated by other components, and the combinations thereof are not particularly limited.

[0076] Examples of the component having the effect of preventing and / or repairing DNA damage include components derived from animals (e.g., Artemia); components derived from plants (e.g., Cat's Claw); and nucleic acid components such as DNA, DNA salts, RNA, and RNA salts. The content of the component having the effect of preventing and / or repairing DNA damage can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.001 to 3% by mass, preferably about 0.01 to 1% by mass, based on the total amount of the composition for external use on the skin of the present invention. When an animal component or a plant component is used, the content is preferably about 0.00001 to 0.1% by mass, more preferably about 0.0001 to 0.01% by mass, based on the total amount of the composition for external use on the skin of the present invention, calculated as an extract such as an extract.

[0077] Examples of whitening ingredients include placenta, kojic acid, ellagic acid, phytic acid, rucinol, chamomilla ET, hydroquinone, potassium 4-methoxysalicylic acid, linoleic acid and its derivatives, vitamins such as ascorbic acid and its salts, vitamins such as pantothenic acid and its derivatives, and batyl alcohol. Furthermore, plant ingredients having a whitening effect may be used as the whitening ingredient. Examples of such plant ingredients include iris, almond, aloe, acerola, oolong tea, Chinese laurel, Scutellaria baicalensis, Coptis chinensis, Hypericum perforatum, white lamb's foot, seaweed, pueraria root, gardenia, lily of the valley, chlorella, rice, rice hyacinth, oryzanol, rice bran, Chinese laurel, Japanese pepper, perilla, peony, cnidium officinalis, soybean, natto, tea, angelica tree, calendula officinalis, witch hazel, safflower, peonies, coix seed, Acacia oleracea, Examples of the plant ingredients include those derived from kiwi, black bean, gentian, gentian, sage, radish, azalea, parsley, holly, hops, thyme, clove, tangerine, licorice, chamomile, prune, meadowsweet, Japanese bean, sorrel, grapefruit, thorn, lemon, pine, neem, artichoke, horsetail, Chinese laurel, evening primrose, bilberry, geranium, Salicornia, white willow, saxifrage, Centella asiatica, rosemary, lavender, devil's claw, and Cornus japonicus. When these plant ingredients are used in the skin topical composition of the present invention, the form of the plant ingredient is not particularly limited, but it can usually be used in the form of a plant extract (plant extract) or essential oil. The parentheses in the plant ingredient indicate the scientific name, alternative name, or herbal name of the plant.

[0078] In the present invention, such whitening ingredients are not particularly limited, but include placenta, kojic acid, ellagic acid, phytic acid, rucinol, chamomilla ET, hydroquinone, potassium 4-methoxysalicylic acid, linoleic acid and its derivatives, ascorbic acid, sodium ascorbate, iris, almond, aloe, acerola, star anise, Scutellaria baicalensis, coptis japonica, Hypericum perforatum, white lamb's foot, seaweed, pueraria lobata, chlorella, rice, rice hyacinth, oryzanol, rice bran, perilla, peony, mulberry bark, soybean, tea, calendula, hawthorn, and the like. Preferably, one or more selected from the group consisting of extracts extracted from mamelis, moutan pea, coix seed, kiwi, sage, parsley, holly, hops, thyme, clove, tangerine, licorice, chamomile, prune, meadowsweet, purple bark, grass larkspur, grapefruit, thorny pear, lemon, pine, neem, artichoke, horsetail, Chinese bark, evening primrose, bilberry, geranium gracilis, glasswort, white willow, saxifrage, centella, rosemary, lavender, devil's claw, and Cornus officinalis, Placenta; Kojic acid; Phytic acid; Hydroquinone; Ascorbic acid, Sodium ascorbate; Iris root extract, Almond oil, Aloe vera extract, Acerola extract, Star anise extract, Scutellaria root extract, Hypericum extract, Lamium extract, Seaweed extract, Pueraria root extract, Chamomile extract, Peony extract, Morus alba extract, Soybean extract, Tea extract, White tea extract, Calendula officinalis, Hamamelis, Coix seed extract, Job's tears extract, Hop extract, Prunus prune extract, Licorice extract, Oil-soluble licorice extract, meadowsweet extract, bead extract, alpinia katsumana seed extract, grapefruit extract, rosa robur extract, lemon extract, kiwi extract, pine extract, neem leaf extract, artichoke extract, horsetail extract, octanoin extract, evening primrose oil, bilberry leaf extract, gelatinosa extract, saltwort extract, white willow extract, Centella asiatica extract, harpagophytum root extract, and Cornus officinalis fruit extract are even more preferred.

[0079] When the skin whitening ingredient described above is blended in the skin topical composition of the present invention, its content can be appropriately selected in consideration of the skin feel and effect when used, and is, for example, about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass, based on the total amount of the skin topical composition. When a plant extract is used, its content is, for example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, more preferably 0.001 to 10% by mass, based on the total amount of the skin topical composition, calculated as an extract such as an extract.

[0080] Examples of anti-inflammatory components include allantoin, calamine, glycyrrhizinic acid or a derivative thereof, or a salt thereof (e.g., dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, etc.), glycyrrhetinic acid or a derivative thereof, or a salt thereof (e.g., glycyrrhetinic acid, stearyl glycyrrhetinate, etc.), zinc oxide, aminocaproic acid, azulene and a derivative thereof (e.g., guaiazulene, azulene, etc.), tocopherol acetate, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid or a derivative thereof, steroids or a derivative thereof, or a salt thereof (e.g., hydrocortisone, prednisolone), ufenamate, bufexamac, ibuprofen piconol, glycol salicylate, and components derived from plants (e.g., comfrey, coptis japonica, Houttuynia cordata). Preferably, it is one or more selected from the group consisting of allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, aminocaproic acid, azulene and its derivatives, or Houttuynia cordata extract, more preferably, it is one or more selected from the group consisting of allantoin, dipotassium glycyrrhizinate, glycyrrhetinic acid, and aminocaproic acid. When an anti-inflammatory component is added, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass, based on the total amount of the skin external composition of the present invention.

[0081] Examples of antibacterial or bactericidal components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, alkyldiaminoglycine hydrochloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, piroctoolamine, zinc pyrithione, miconazole or a salt thereof, chlorobutanol, glyceryl caprylate, ethylhexylglycerin, iodide propynyl butylcarbamate, caprylhydroxamic acid, phenethyl alcohol, methylisothiazolinone, sorbic acid, β-glycyrrhetinic acid, azelaic acid, and components derived from plants (e.g., sophora flavescens, rosemary, mulberry, eucalyptus, etc.). Among them, one or more selected from the group consisting of salicylic acid, benzalkonium chloride, ethanol, cetylpyridinium chloride, cetyltrimethylammonium chloride, gluconic acid, isopropylmethylphenol, paraben, phenoxyethanol, cetylpyridinium chloride, zinc pyrithione, chlorobutanol, ethylhexylglycerin, iodopropynyl butylcarbamate, caprylhydroxamic acid, sorbic acid, β-glycyrrhetinic acid, rosemary extract, and eucalyptus extract are preferred. When an antibacterial or bactericidal component is incorporated, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.0003 to 10% by mass, preferably about 0.001 to 5% by mass, based on the total amount of the composition for external use on skin of the present invention.

[0082] Examples of the refreshing agent include menthol and its derivatives, camphor, borneol, geraniol, cineol, anethole, limonene, eugenol, and other terpenes (which may be d-, l-, or dl-isomers); and essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine. Among these, combinations with l-menthol, menthyl glyceryl ether, menthyl lactate, menthyl 3-hydroxybutyrate, menthoxypropanediol, camphor, eucalyptus oil, peppermint oil, and peppermint oil are preferred. When a refreshing agent is added, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, 0.001 to 5% by mass or more, preferably 0.005 to 3% by mass or more, and more preferably 0.01 to 1% by mass or more, based on the total amount of the skin external composition of the present invention.

[0083] Examples of the organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, pantothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid, and salts thereof. Examples of the salts include salts of mineral acids such as sulfuric acid, hydrochloric acid, and phosphoric acid, salts of organic acids such as maleic acid and methanesulfonic acid, salts of alkali metals such as sodium and potassium, alkaline earth metal salts, ammonium salts, salts of basic amino acids, and salts of amines such as triethanolamine. Of these, one or more selected from the group consisting of gluconic acid, citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and glycyrrhetinic acid are more preferred.

[0084] Examples of anti-glycation ingredients include plant extracts such as Budreja axillaris leaf extract, plum fruit extract, edelweiss extract, ginkgo extract, cherry leaf extract, pomegranate extract, psyllium baicalensis extract, hawthorn extract, peony extract, dokudami extract, bilberry leaf extract, green tea extract, black tea extract, horse chestnut extract, Roman chamomile extract, and mugwort extract, evening primrose oil, amla fruit, fruit juice or extracts thereof, L-arginine, L-lysine, hydrolyzed casein, hydrolyzable tannin, and carnosine. When an anti-glycation ingredient is incorporated, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.0003 to 10% by mass, preferably about 0.001 to 5% by mass, based on the total amount of the skin external composition of the present invention.

[0085] Examples of cell activation components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid, and pyrroloquinoline quinones; α-hydroxy acids such as gluconic acid, phytic acid, glycolic acid, and lactic acid; tannins, flavonoids, saponin, allantoin, placenta, proteoglycan, photosensitizer No. 301, and components derived from plants (for example, soybean, bilberry, lemongrass, aloe vera, chlorella, bean berry, coix seed, chamomile, houttuynia cordata, hops, carrot, etc.); royal jelly, royal jelly extract; whey-derived extracts such as whey, yogurt extract, and hydrolyzed milk protein, and yeast extract. When a cell-activating component is incorporated, its content can be appropriately selected taking into consideration the feel and effect on the skin when used, and is, for example, about 0.0003 to 10 mass%, preferably about 0.001 to 5 mass%, relative to the total amount of the topical skin composition of the present invention.

[0086] Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, aluminum allantoin salt, zinc paraphenolsulfonate, zinc sulfate, aluminum potassium sulfate, and basic zinc aluminum lactate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid; and components derived from plants (e.g., seaweed, thyme, black tea, oolong tea, green tea, hypericum, hamamelis, loquat, peonies, saxifrage, rooibos, astragalus, artichoke, chamomile, eucalyptus, lemon, rosemary, and burnet). When an astringent component is incorporated, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.0003 to 20% by mass, preferably about 0.01 to 10% by mass, based on the total amount of the skin external composition of the present invention.

[0087] Examples of antioxidant components include butyl hydroxyanisole, dibutyl hydroxytoluene, sodium hydrogen sulfite, sodium pyrosulfite, erythorbic acid and its salts, ascorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, hypotaurine, and plants (e.g., St. John's wort). Examples of such ingredients include those derived from lysomum, pueraria lobata, bilberry, scutellaria, passionflower, grapefruit, peony, meadowsweet, perilla, honeysuckle, sage, yarrow, mallow, meadowsweet, mulberry, clove, tangerine, gelatin, loquat, safflower, moutan, hops, eucalyptus, saxifrage, rooibos, lemongrass, soybean, mugwort, evening primrose, rosemary, and lavender. When an antioxidant ingredient is added, the content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.00001 to 10% by mass, preferably about 0.0001 to 5% by mass, and more preferably 0.001 to 5% by mass, based on the total amount of the composition for external use on skin of the present invention.

[0088] Examples of anti-aging ingredients include hydrolyzed soy protein, retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, peptides (caproyl tetrapeptide-3, oligopeptide-24, etc.), plants (artichoke, Rosa robur, seaweed, bilberry, white birch, plantain, Angelica acutiloba, Scutellaria baicalensis, Hypericum perforatum, comfrey, neem, wild rose, Belamcanda chinensis, Geranium globulus, Lily of the valley, Peony root), etc. Among these, hydrolyzed soy protein, retinol, retinol acetate, retinol palmitate, caprooyl tetrapeptide-3, oligopeptide-24, artichoke leaf extract, seaweed extract, bilberry leaf extract, comfrey leaf extract, neem leaf extract, and Geranium globulus extract are preferred. When an anti-aging component is added, the content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass, based on the total amount of the external skin composition of the present invention.

[0089] Moisturizing ingredients include, for example, amino acids and derivatives thereof such as alanine, serine, aspartic acid, glycine, proline, hydroxyproline, glucosamine, theanine, and arginine; polyhydric alcohols such as glycerin, 1,3-propanediol, and 1,3-butanediol; sugar alcohols such as sorbitol, xylitol, erythritol, maltose-sucrose condensates (gluco-oligosaccharides), hydrolyzed xylan (xylo-oligosaccharides), and glyceryl glucoside; glycosyltransferases such as glyceryl glucoside, glyceryl stearate, and glyceryl glycerides. lehalose, trehalose; ceramide, glucosylceramide, cholesterol, phytosterol, cholesterol derivatives, phytosterol derivatives; phospholipids such as lecithin and hydrogenated lecithin; NMF-derived components such as lactic acid, sodium lactate, sodium pyrrolidone carboxylate, and urea; hyaluronic acid (including hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, etc.); salts of hyaluronic acid (e.g., sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, etc.); hyaluronic acid Examples of such ingredients include hyaluronic acid derivatives (acetylated hyaluronic acid or its salts (e.g., sodium acetylated hyaluronate, zinc acetylated hyaluronate, etc.), crosslinked hyaluronic acid derivatives (sodium hyaluronate crosspolymer, etc.), sodium carboxymethyl hyaluronate, unsaturated hyaluronic acid or its salts, hydrolyzed alkyl (C12-13) glyceryl hyaluronate, cationic hyaluronic acid derivatives (hydroxypropyltrimonium hyaluronate, etc.), dimethylsilanol hyaluronate, etc.); chondroitin sulfate or its salts (sodium chondroitin sulfate, potassium chondroitin sulfate, sodium dermatan sulfate, potassium dermatan sulfate, etc.); heparinoids, collagen, elastin, keratin, chitin, chitosan, etc. and their hydrolysates; hydroxyethyl urea; and ingredients derived from plants (e.g., aloe, seaweed, pueraria lobata, chlorella, lemongrass, chamomile, witch hazel, tea, perilla, grapefruit, Gynostemma pentaphyllum, etc.).Among these, one or more selected from glycine, arginine, glycerin, 1,3-propanediol, 1,3-butanediol, glycosyl trehalose, ceramide, glucosylceramide, cholesterol, cholesterol derivatives, phytosterol derivatives, hydrogenated lecithin, lactic acid, sodium lactate, sodium pyrrolidone carboxylate, urea, hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, acetylated hyaluronic acid, sodium hyaluronate crosspolymer, hydroxypropyltrimonium hyaluronate, dimethylsilanol hyaluronate, collagen, elastin, keratin, hydroxyethyl urea, seaweed extract, chamomile extract, witch hazel extract, and Gynostemma pentaphyllum extract are preferred. When a moisturizing component is incorporated, its content can be appropriately selected taking into consideration the feel and effect on the skin when used, but is, for example, about 0.001 to 20 mass%, preferably about 0.01 to 10 mass%, relative to the total amount of the topical skin composition of the present invention.

[0090] Examples of polyhydric alcohols include diols having 2 to 4 or 11 or more carbon atoms, polyhydric alcohols having 3 or more hydroxyl groups, and the like, such as glycerin, diglycerin, triglycerin, propylene glycol, 1,3-butanediol, 1,3-propanediol, ethylene glycol, diethylene glycol, isoprene glycol, and 1,3-butylene glycol. Among them, a combination of one or more selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-propanediol, and 1,3-butylene glycol is preferred. When a polyhydric alcohol is added, its content can be appropriately selected in consideration of the feel on the skin and the moisturizing effect, and is, for example, about 0.1 to 20% by mass, preferably about 0.5 to 15% by mass, based on the total amount of the skin topical composition of the present invention.

[0091] Examples of keratin softening ingredients include adipic acid, lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid, fruit acid, phytic acid, urea, and sulfur. Among them, a combination of lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, and citric acid is preferred. When a keratin softening ingredient is added, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, 0.0001 to 50% by mass, preferably about 0.001 to 50% by mass, and more preferably about 0.01 to 25% by mass, based on the total amount of the skin external composition of the present invention.

[0092] Examples of vitamins include retinol derivatives such as retinol, retinol acetate, retinol palmitate, retinol propionate, and retinol linoleate; vitamin A such as retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoic acid, d-δ-tocopheryl retinoate, α-tocopheryl retinoate, and β-tocopheryl retinoate; provitamins such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, and echinenone. Vitamin A, such as δ-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, tocopherol nicotinate, dl-α-tocopherol acetate, tocopherol linoleate, and tocopherol (linoleate / oleate); Vitamin B1, such as γ-oryzanol, thiamine, and their salts (e.g., dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine diphosphate); riboflavin, flavin mononucleotide, flavin adenine dinucleotide, etc. Vitamin B2 such as riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate, and their salts; nicotinic acids other than the above component (A) such as benzyl nicotinate, methyl nicotinate, and nicotinic acid; vitamin C such as ascorbic acid and sodium ascorbate; vitamin D such as methylhesperidin, ergocalciferol, and cholecalciferol; vitamin K such as phylloquinone and farnoquinone; pyridoxine hydrochloride Vitamin B6 such as pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantetheine, D-pantethine, coenzyme A, pantothenyl ethyl ether, and calcium pantetheine sulfonate; biotins such as biocytin;Other examples include vitamin-like action factors such as carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, hesperidin and glucosyl hesperidin, ubiquinone, and salts thereof. Among these, combinations with vitamin B, vitamin C, vitamin E, vitamin A, and vitamin-like action factors are preferred, and one or more selected from the group consisting of pyridoxine hydrochloride, pantothenyl alcohol (panthenol), riboflavin, cyanocobalamin, ascorbic acid, dl-α-tocopherol acetate, retinol, retinol palmitate, retinol propionate, retinol acetate, pyrroloquinoline quinone or a salt thereof, ubiquinone, and γ-oryzanol are more preferred. When vitamins are added, their content can be appropriately selected taking into consideration the feel and effect on the skin when used, and is, for example, about 0.001 to 30% by mass, preferably about 0.01 to 25% by mass, and more preferably about 0.01 to 20% by mass relative to the total amount of the external skin composition of the present invention;

[0093] Examples of blood circulation-promoting ingredients include ingredients derived from plants (e.g., ginseng, angelica, ginseng, fennel, Japanese oak, Dutch oak, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, ginger, European hawthorn, European juniper, Cnidium rhizome, Swertia japonica, thyme, clove, Chinese citrus fruit, Angelica acutiloba, Peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu, coix seed, rosemary, rose hip, peach, apricot, walnut, corn); dl-α-tocopherol acetate, tocopherol nicotinate, glucosyl hesperidin, hesperidin, caffeine, chili pepper tincture, gamma oryzanol, capsaicin, nicotinic acid benzyl ester, etc. When a blood circulation promoting component is blended, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.00001 to 10% by mass, preferably 0.0001 to 5% by mass, and more preferably about 0.001 to 5% by mass, based on the total amount of the composition for external use on the skin of the present invention. When a plant-derived component is used, its content is, for example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, and more preferably 0.001 to 10% by mass, based on the total amount of the composition for external use on the skin, calculated as an extract such as an extract.

[0094] Examples of the sebum-adsorbing component include talc, mica, hydroxyapatite, zinc oxide, and aluminum silicate. Among these, mica, hydroxyapatite, and zinc oxide are preferred, and mica is particularly preferred. When the sebum-adsorbing component is incorporated, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.001 to 35% by mass, preferably about 0.1 to 25% by mass, based on the total amount of the external skin composition of the present invention.

[0095] Examples of the above peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, gelatin, elastin, elastin hydrolyzed peptides, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.), and the like. Among them, a combination with one or more selected from the group consisting of keratin decomposition peptides, hydrolyzed keratin, fish-derived collagen elastin, elastin decomposition peptides, collagen decomposition peptides, hydrolyzed collagen, succinylated atelocollagen, elastin decomposition peptides, hydrolyzed silk, soy protein decomposition peptides, and hydrolyzed soy protein is more preferred. When a peptide or a derivative thereof is blended, its content can be appropriately selected in consideration of the feel and effect on the skin, and is, for example, about 0.0001 to 35% by mass, preferably about 0.001 to 10% by mass, based on the total amount of the composition for external use on skin of the present invention.

[0096] Examples of the above amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, epsilon aminocaproic acid, tryptophan, ornithine, lauroyl glutamic acid di(phytosteryl / octyldodecyl), lauroyl glutamic acid di(octyldodecyl / phytosteryl / behenyl), etc. These amino acids or derivatives thereof may be solvates such as hydrates, and may be any of d-, l-, and dl-isomers. Among these, one or more selected from the group consisting of l-amino acids and derivatives thereof are preferred.

[0097] In addition to the components (A) to (C), the skin topical composition of the present invention may also contain components that are commonly used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc., depending on the intended use or dosage form of each component. The components that can be added are not particularly limited, and may include additives such as bases or carriers, surfactants, thickeners, antioxidants, preservatives, pH adjusters, chelating agents, stabilizers, irritation reducers, colorants, dispersants, and fragrances. These components may be added alone or in any combination of two or more. The content of these components may be appropriately determined within the ranges known in the art without impairing the effects of the present invention. Furthermore, components that fall under the following multiple components may be added as components with any of the functions.

[0098] Examples of the base or carrier include aqueous bases such as water; hydrocarbons such as liquid paraffin, liquid isoparaffin, squalane, petrolatum, paraffin, microcrystalline wax, polybutene, polyethylene powder, gelled hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, light liquid paraffin, and light isoliquid paraffin; methyl polysiloxane, crosslinked methyl polysiloxane, highly polymerized methyl polysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified Silicone oils such as polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, and cholesterol; higher fatty acids such as isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, and behenic acid; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methylcellulose; polyvinylpyrrolidone; polyvinyl butyrate; polyethylene glycol; dioxane; butylene glycol adipate polyester;Isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra 2-ethylhexanoate, diisopropyl adipate, decyl oleate, isodecyl oleate, hexyldecyl dimethyloctanoate, diisopropyl sebacate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, diisopropyl adipate, isopropyl isononanoate Redecyl, cetyl lactate, isostearyl isostearate, cholesteryl 12-hydroxystearate, cholesteryl stearate, cholesteryl oleate, phytosteryl macadamiate, phytosteryl oleate, dextrin palmitate, inulin stearate, hydrogenated jojoba oil, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, tri-2-ethylhexyl trimellitate, trimellitic acid Tridecyl trimethylolpropane tri-2-ethylhexyl, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane triisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, oleyl oleate, phytosteryl / octyldodecyl lauroyl glutamate, ... Esters such as di(octyldodecyl / phytosteryl / behenyl) ylglutamate, triethyl citrate, dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleyl dimer dilinoleate, dipentaerythrityl tripolyhydroxystearate, and glyceryl tri(behenate / isostearate / eicosandioate); waxes such as jojoba oil, miu wax, candelilla wax, rice bran wax, cotton wax, carnauba wax, and lanolin;Examples of the oils and fats include avocado oil, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, safflower oil, apricot kernel oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, shea butter, camellia oil, rapeseed oil, sesame oil, cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, Japanese wax kernel oil, Japanese wax, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, and evening primrose oil; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer; lower alcohols such as ethanol and isopropanol; sugar alcohols such as sorbitol, xylitol, erythritol, and mannitol; and water. The base or carrier selected from these components may be used alone or in combination of two or more. The amount of each of these components used is appropriately selected from the range known to those skilled in the art. When the skin topical composition of the present invention contains water, the content of water varies depending on the form of the cosmetic product and is not particularly limited. For example, the amount of water is preferably 5 to 99%, more preferably 8 to 95%, and even more preferably 10 to 90% based on the total amount of the skin topical composition of the present invention.

[0099] Examples of the surfactant include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monostearate, diglycerol sorbitan tetra-2-ethylhexyl acid, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, and sorbitan olivate; polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (80) sorbitan monolaurate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (80) sorbitan monolaurate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (80) sorbitan monooleate, and polyoxyethylene (80) sorbitan monooleate. Polyoxyethylene (20) sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan isostearate; glycerin fatty acid esters such as glycerin monooleate, glycerin monostearate, and glycerin monomyristate; glycerin alkyl ethers such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether; diglyceryl monostearate, decaglyceryl decaglyceryl ether, decaglyceryl decaisostearate, and diglyceryl monostearate. Polyglycerol fatty acid esters such as lyceryl diisostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 50, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 80; polyoxyethylene glycerol fatty acid esters such as polyoxyethylene monococoate glyceryl; polyoxyethylene alkyl ethers such as polyoxyethylene (20) phytosterol, polyoxyethylene (30) phytosterol, polyoxyethylene (25) phytostanol, polyoxyethylene (30) cholestanol, and other polyoxyethylene sterols and hydrogenated sterols; sucrose fatty acid esters; polyoxyalkylene alkyl (or alkenyl) ether sulfates, ether carboxylates, alkyl phosphate esters, N-acyl amino acid salts, and acylated taurates; amines such as stearylamine and oleylamine;Examples of such surfactants include silicone surfactants such as polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone; and naturally derived surfactants such as lecithin, hydrogenated lecithin, saponin, sodium surfactin, cholesterol, and bile acid.

[0100] Examples of thickening agents include gums (gellan gum, xanthan gum, sclerotium gum, locust bean gum, biosaccharide gum, tamarind gum, quince seed, gum arabic, tara gum, guar gum, galactan, gum arabic, tragacanth gum, etc.); carrageenan, curdlan, succinoglucan; heparinoids; alginates (alginic acid, sodium alginate, propylene glycol alginate, etc.); agar (including agarose); gelatin, pectin; pullulan; mannan; vinyl thickening agents such as polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, and carboxyvinyl polymers; methylcellulose, ethylcellulose, hydorhexyl cellulose, and the like. Examples of the thickeners include cellulose-based thickeners such as hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, and hydrophobized hydroxypropyl methyl cellulose, dextran, acrylic acid alkyl methacrylate copolymers, sodium polyacrylate, bentonite, dextrin fatty acid esters, dimethyl distearyl ammonium hectorite, polyethylene glycol, macrogol, (hydroxyethyl acrylate / Na acryloyldimethyl taurate) copolymers, (ammonium acryloyldimethyl taurate / vinyl pyrrolidone) copolymers, etc. Among these, xanthan gum, acrylic acid alkyl methacrylate copolymers, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymers, dimethyl distearyl ammonium hectorite, (hydroxyethyl acrylate / Na acryloyldimethyl taurate) copolymers, and (ammonium acryloyldimethyl taurate / vinyl pyrrolidone) copolymers are preferred.

[0101] Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, tocopherol, tocopherol derivatives, erythorbic acid, sodium erythorbate, L-cysteine ​​hydrochloride, ubiquinones such as coenzyme Q10, lignans such as sesamin, curcumin, capsaicin, gingerol, resveratrol, anthocyanin, cyanidin, bilberry extract, and analogs or derivatives thereof.

[0102] Examples of preservatives or antiseptics include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, methylisothiazolinone, iodopropynyl butylcarbamate, caprylhydroxamic acid, and phenethyl alcohol.

[0103] Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), potassium carbonate, sodium bicarbonate, carbon dioxide, organic bases (arginine triethanolamine, diisopropanolamine, triisopropanolamine, etc.), and the like.

[0104] Examples of chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetate (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, etc. Among these, sodium edetate is preferred.

[0105] Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, and butylhydroxyanisole.

[0106] Examples of irritation reducers include licorice extract and polyvinylpyrrolidone.

[0107] Colorants include pigment grade titanium oxide, zinc oxide, iron oxide, organic pigments, talc, sericite, mica, synthetic mica, chromium oxide, and gunjo.

[0108] Powders may also be blended to improve the feel or impart a makeup effect. Specific examples of such powders include boron nitride, silica, alumina, aluminum hydroxide, metal soaps, silicone powders, and polymethyl methacrylate.

[0109] [viscosity] The viscosity (25°C) of the topical skin composition of the present invention is not particularly limited as long as it is within the range of 1 to 500,000 mPa·s, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 2 to 500,000 mPa·s, more preferably 3 to 300,000 mPa·s, and even more preferably 5 to 200,000 mPa·s. A topical skin composition with such a viscosity can be obtained mainly by appropriately selecting the type and content of the thickener, which is an added component.

[0110] In the present invention, the viscosity is measured using a single cylinder rotational viscometer (Brookfield type viscometer) in accordance with the viscosity measurement method described in the general test methods of the Japanese Pharmacopoeia, 17th Edition. In this application, an RB-80H (Toki Sangyo) is used, and the selection of conditions such as the rotor and rotation speed is in accordance with the instruction manual for this machine, and the viscosity is measured at 25°C. The single cylinder rotational viscometer is described below. A single cylinder rotational viscometer is a viscometer that measures the torque when a cylinder in a liquid is rotated at a constant angular velocity. The viscosity η of the liquid is calculated by the following formula, with the device constant KB being experimentally determined in advance using a standard liquid for calibrating the viscometer. η=KB × T / ω η: Viscosity of the liquid (mPa s) KB: Equipment constant (rad / cm 3 ) ω: Angular velocity (rad / s) T: Torque acting on the cylindrical surface (10 -7 N m)

[0111] [pH] The topical skin composition of the present invention may generally have a liquid pH of 2.0 to 9.0, but from the viewpoints of low irritation to the skin and mucous membranes and good feel on the skin, the pH is preferably 3.0 to 8.5, more preferably 4.0 to 8.0, even more preferably 4.5 to 7.5, and even more preferably 5.0 to 7.5.

[0112] [Angular frequency value of sol-gel transition point in dynamic viscoelasticity] The angular frequency of the sol-gel transition point in the dynamic viscoelasticity of the topical skin composition of the present invention is the value of the angular frequency ω at which the storage modulus G' and the loss modulus G" are equal, and can be obtained, for example, by dynamic viscoelasticity measurement using a rheometer. More specifically, using an MCR 102 (manufactured by Anton Paar) as a rheometer and a PP25-SN31369 (d=1 mm) as a measuring jig, measurements were performed at 25°C and an oscillation angle (γ) of 1% in the angular frequency (ω) range of 100 to 0.1 (rad / s).

[0113] From the viewpoint of achieving a remarkable effect of the present invention, the angular frequency (rad / s) of the sol-gel transition point of the composition for external use on skin of the present invention is preferably 3 or more, more preferably 4 or more, and even more preferably 5 or more. The higher the angular frequency of the sol-gel transition point, the slower the restoration speed becomes, and the more easily the composition will exhibit viscous properties when force is applied to it with a finger or the like, and the easier it is to scoop up the composition, and the better it spreads and blends with the skin when used.

[0114] [How to improve usability] The present invention also includes a method for improving the feel of a topical skin composition containing (A) hydrophobically modified polyether urethane. According to the present invention, the topical skin composition contains (A) hydrophobically modified polyether urethane; and (B) one or more components selected from the group consisting of nicotinamide, vitamin C derivatives, arbutin, and tranexamic acids, thereby improving the feel of the topical skin composition containing (A) hydrophobically modified polyether urethane. Here, the improvement of the feel of the composition means, for example, that the topical skin composition spreads better when applied to the skin, that the composition blends well with the skin, and the like.

[0115] [Method of manufacturing the composition for external use on skin] The method for producing the topical skin composition of the present invention is not particularly limited, and the composition can be produced by appropriately selecting and mixing the above-mentioned components (A) to (C) as well as the other components described above, and emulsifying the composition as necessary in a conventional manner.

[0116] [Properties / Formulation] The properties of the skin external composition of the present invention are not particularly limited, and can be liquid, fluid, or semi-solid. The formulation form can be, for example, a liquid, suspension, emulsion, cream, milky lotion, ointment, gel, liniment, lotion, aerosol, a sheet agent in which a nonwoven fabric is impregnated with a drug solution, a stick agent, or the like. Among them, emulsion, cream, milky lotion, ointment, gel, lotion, and sheet agent are preferable, and cream, milky lotion, gel, lotion, sheet agent, and stick agent are particularly preferable. In addition, when an oily base and an aqueous base are contained, such as emulsion, cream, and ointment, they may be W / O type or O / W type, but O / W type is more preferable from the viewpoint of ensuring the appropriate thickening of the skin external composition of the present invention and from the viewpoint of the feeling of use (stickiness, spreadability, moist feeling, freshness, penetration feeling, etc.).

[0117] The topical skin composition of the present invention is not particularly limited, but from the viewpoint of significantly achieving the effects of the present invention, it is preferable that the preparation is a homogeneous preparation that does not contain non-uniform particles such as gel particles.

[0118] [Usage] Specific examples of applications of the composition for external use in the case of quasi-drugs or cosmetics include skin lotions, milky lotions, gels, creams, beauty essences, sunscreen cosmetics, packs, masks, hand creams, all-in-one gels, all-in-one creams, wipe-off cosmetics, stick-shaped cosmetics, scalp cosmetics, mists, body lotions, and body creams; cleansing cosmetics such as face washes, hand soaps, makeup removers, body shampoos, shampoos, rinses, and treatments; face makeup cosmetics such as BB creams, foundations, and makeup bases; lip cosmetics such as lip creams, lip liners, and lip gels; hair cosmetics such as hair rinses, hair treatments, hair conditioners, hair gels, hair mousses, hair mist, hair lotions, and styling agents. Among these, skin external compositions are particularly preferred. That is, the composition for external use of the present invention can be a skin external composition for pharmaceuticals, quasi-drugs, or cosmetics. The formulation of the topical composition for skin is the same as that of the topical composition of the present invention. Also, the base or carrier, additives, and active ingredients that can be used, as well as their preferred embodiments, are the same as those of the topical composition of the present invention.

[0119] [container] The skin topical composition of the present invention can be stored and used in a container of a shape and material appropriately selected according to the purpose and application. Specific examples of containers include spray type, bottle type, tube type, jar type, dropper type, dispenser type, stick type, pouch bag, and cheer pack. The skin topical composition of the present invention can be applied, sprayed, etc. smoothly even after gelation due to the physical properties of the hydrophobically modified polyether urethane, and can increase the freedom of formulation design even in the case of highly viscous formulations such as formulations containing a high concentration of (B) component or formulations containing a high concentration of hydrophobically modified polyether urethane. In other words, it can be easily used in a wide variety of containers such as sprays, bottles, tubes, and dispensers, as well as jars, for formulations of various viscosities.

[0120] Examples of container materials include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (aluminum, etc.). Taking into consideration strength, flexibility, weather resistance, stability of components, and the like, these materials can be used as container materials by performing various coating processes, combining these materials by mixing, for example, or laminating them. Examples of coating materials include epoxy resin and polyamideimide. Among them, it is preferable to use polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, or metal (aluminum, etc.).

[0121] [How to use, etc.] The skin topical composition of the present invention is expected to have effects such as blood circulation promotion, anti-inflammation, ceramide synthesis promotion, whitening, anti-wrinkle, and anti-aging due to the physiological activity of component (B), and is useful as a multifunctional preparation including a whitening agent, sunscreen, etc. The skin topical composition of the present invention can be used in a known or commonly used dosage form, once or several times a day depending on the purpose. EXAMPLES

[0122] Next, the present invention will be specifically described with reference to examples and test examples, but the present invention is not limited to the following examples and test examples.

[0123] [Raw materials used] The raw materials used in the following test examples and manufacturing examples are as follows. The values ​​in each table of the test examples are the content of the ingredient itself described in the ingredient name (all units are mass %). The values ​​in each table of the formulation examples are the blending amounts of the raw material products themselves described below. (PEG-240 / Decyltetradeceth-20 / HDI) copolymer: Adekanol GT700 Polyoxyethylene methyl glucoside (10E.O.): Macbiobride MG-10E (NOF Corporation) Polyoxypropylene methyl glucoside (10P.O.): Macbiobride MG-10P (manufactured by NOF Corporation) Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O.) (8E.O.) (5P.O.): WILBRIDE S-753 (manufactured by NOF Corporation) Polyoxyethylene polyoxypropylene butyl ether (17E.O.) (17P.O.): Unilube 50MB-26 (manufactured by NOF Corporation) 2-Methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer: Lipidure PMB-RT (NOF Corporation) Bisethoxydiglycol cyclohexanedicarboxylate: Neosolue aqulio (manufactured by Nippon Fine Chemicals Co., Ltd.) Decaglyceryl (eicosandioate / tetradecanedioate): Neosolue-AquaS (manufactured by Nippon Fine Chemicals Co., Ltd.) Polyoxyethylene glyceryl ether (26E.O.): Brownon GL-26 (manufactured by Aoki Oil Co., Ltd.) Diethoxyethyl succinate: CRODAMOL DES-LQ (manufactured by Croda Japan Co., Ltd.)

[0124] [Test Example 1. Comparison of angular frequency values ​​of sol-gel transition points of skin topical compositions 1] A sample was prepared with the composition shown in Table 1 below. Using an MCR 102 (manufactured by Anton Paar) rheometer and a PP25-SN31369 (d=1mm) measuring tool, measurements were taken at 25°C, oscillation angle (γ)=1%, and angular frequency (ω) range of 100-0.1 (rad / s). The angular frequency value of the sol-gel transition point obtained and the results of evaluation according to the following evaluation criteria are also shown in Table 1. When the angular frequency value of the sol-gel transition point was less than 2.5 rad / s, the recovery rate of the formulation was high and the formulation did not stretch or blend well, so it was determined that the formulation was not suitable for use. <Evaluation criteria for angular frequency of sol-gel transition point> × Angular frequency of sol-gel transition point (rad / s) less than 2.5 △ Angular frequency of sol-gel transition point (rad / s) 2.5 or more and less than 3 Sol-gel transition temperature angular frequency (rad / s) 3 to less than 6 ◎ Sol-gel transition temperature angular frequency (rad / s) 6 or higher

[0125] The appearance of the obtained preparation was also observed, and the transparency of the preparation was judged according to the following criteria. The higher the transparency of the preparation, the greater the range of applications for various containers and specifications. The evaluation results are shown in Table 1. <Evaluation of formulation transparency> × The preparation is turbid and has low transparency. △: Slightly cloudy, but mostly transparent ○ Transparent appearance

[0126] [Table 1]

[0127] In the presence of hydrophobically modified polyether urethane (PEG-240 / decyltetradeceth-20 / HDI) copolymer, the angular frequency of the sol-gel transition point was less than 3 in Comparative Examples 1-1 to 5 that did not contain nicotinamide, whereas in Examples 1-1 to 6 that contained hydrophobically modified polyether urethane and nicotinamide, all showed large values ​​of 5 rad / s or more, and the addition of nicotinamide increased the angular frequency by more than three times. From the above, the angular frequency of the sol-gel transition point increased in the presence of component (A) and component (B). All of the formulations in the examples were easy to scoop and had a good feel (spreadability and affinity) when used.

[0128] Furthermore, when comparing Comparative Examples 1-1, 3, and 4 with Examples 1-1, 3, and 4, when the formulation contained hydrophobically modified polyether urethane and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O.) (8E.O.) (17P.O.) or polyoxyethylene polypropylene butyl ether (17E.O.) (17P.O.) as component (C), the addition of nicotinamide also had the effect of eliminating the cloudy appearance of the formulation.

[0129] [Test Example 2. Comparison of angular frequency values ​​of sol-gel transition points of skin topical compositions 2] Compositions for external use on the skin having the compositions shown in Tables 2 to 6 below were prepared. Then, evaluation was performed in the same manner as in Test Example 1. That is, the angular frequency value at the sol-gel transition point was measured, and judgment was performed according to the above-mentioned evaluation criteria. In addition, the appearance of the obtained preparation was observed, and the transparency of the preparation was judged according to the above-mentioned judgment criteria. The results are shown in Tables 2 to 6.

[0130] [Table 2]

[0131] [Table 3]

[0132] [Table 4]

[0133] [Table 5]

[0134] [Table 6]

[0135] As in Test Example 1, the preparations of the examples containing at least the components (A) and (B) all had a sol-gel transition point with an angular frequency of 2.5 rad / s or more, and had a good feel when used (spreadability and compatibility). It was also revealed that when nicotinamide was used as the component (B), a skin topical composition with a particularly high sol-gel transition point with an angular frequency was obtained.

[0136] In addition, the angular frequency of the sol-gel transition point of each of the skin topical compositions of the Examples in Tables 2 to 6 was measured after storage at 60° C. for one week, and the results showed that the value did not change significantly from before storage. Therefore, it was clear that the effects of the present invention are stably maintained during storage.

[0137] [Formulation example] Based on the formulations in Tables 7 to 45 below, external skin compositions of the present invention (Formulation Examples 1 to 39) were prepared.

[0138] [Table 7]

[0139] [Table 8]

[0140] [Table 9]

[0141] [Table 10]

[0142] [Table 11]

[0143] [Table 12]

[0144] [Table 13]

[0145] [Table 14]

[0146]

Table 15

[0147]

Table 16

[0148]

Table 17

[0149]

Table 18

[0150]

Table 19

[0151]

Table 20

[0152]

Table 21

[0153]

Table 22

[0154]

Table 23

[0155]

Table 24

[0156]

Table 25

[0157]

Table 26

[0158]

Table 27

[0159]

Table 28

[0160]

Table 29

[0161]

Table 30

[0162]

Table 31

[0163]

Table 32

[0164]

Table 33

[0165]

Table 34

[0166]

Table 35

[0167]

Table 36

[0168]

Table 37

[0169]

Table 38

[0170]

Table 39

[0171]

Table 40

[0172]

Table 41

[0173]

Table 42

[0174]

Table 43

[0175]

Table 44

[0176]

Table 45

Claims

1. (A) a hydrophobically modified polyether urethane, and (B) nicotinamide, Contains the content of the component (B) is 3 to 10% by mass relative to the total amount of the topical skin composition; the total content of the component (A) in the composition for external use on skin is 0.5 to 2% by mass relative to 1% by mass of the total content of the component (B); A composition for external use on skin having an angular frequency at the sol-gel transition point in dynamic viscoelasticity of 2.5 rad / s or more at 25°C.

2. The topical skin composition according to claim 1, wherein the component (A) is a hydrophobically modified polyether urethane represented by the following chemical formula (I): R １ -{(O-R ２ ) ｋ -OCONH-R ３ [-NHCOO-(R ４ -O) ｎ -R ５ ] ｈ } ｍ (I) (In the ceremony R １ represents a hydrocarbon group, and R ２ and R ４ each independently represents an alkylene group having 2 to 4 carbon atoms; R ３ represents a hydrocarbon group that may have a urethane bond, is linear, branched, or contains an aliphatic or aromatic ring; R ５ represents a branched hydrocarbon group; m is an integer of 2 or greater, h is an integer of 1 or greater, k and n are each independently an integer ranging from 0 to 1000, and k+n≧1).

3. The composition for external use on skin according to claim 1 or 2, further comprising (C) one or more components selected from the group consisting of phenoxyethanol, dipropylene glycol, and amphiphilic components.

4. The topical skin composition according to any one of claims 1 to 3, wherein the amphiphilic component of component (C) is one or more selected from the group consisting of 2-methacryloyloxyethyl phosphorylcholine-containing polymers, dicarboxylic acid esters, alkanediols having 5 to 10 carbon atoms, and alkylene oxide derivatives represented by the following chemical formula (II): Z-[O-(AO) ａ (EO) ｂ -(BO) ｃ -+] ｎ (II) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a group obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively, and are independently 0 to 200; a, b, and c are not all 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different, When Z is a hydrogen atom, n is 1.

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