Topical Compositions

Abstract

The present invention relates to phytantriol and C 4~6 The present invention relates to a topical composition comprising a mixture of alkylglycerins and the use of said mixture for reducing and / or preventing microbial growth.

Description

Detailed Description of the Invention

[0001] The present invention relates to phytantriol and C 4~6 The present invention relates to a topical composition comprising a mixture of alkylglycerins and the use of said mixture for reducing and / or preventing the growth of microorganisms.

[0002] Microorganisms cause the decay of food and everyday items such as cosmetic compositions, household products, plastics, paper or paints. Therefore, reducing the growth of microorganisms is essential not only to improve the shelf life (storage stability) of the product itself, but also to guarantee consumer safety. Therefore, preservatives are generally added to the respective products. However, since the use of certain preservatives is under strong public debate, options that can reduce or even avoid such agents are highly desired in the industry. Since cosmetics are particularly susceptible to attack by microorganisms, there is a continuous demand for alternatives to help cosmetic formulations remain safe and prevent deterioration over time.

[0003] Therefore, the problem to be solved by the present invention is to provide a novel, safe and effective method for reducing or inhibiting the growth of microorganisms.

[0004] Surprisingly, phytantriol and C 4~6 It has been found that the combination of alkyl glycerols shows synergistic antimicrobial action.This surprising discovery is very advantageous, because it can be used to improve the stability and shelf life of cosmetic compositions, household products, plastics, paper and / or paints by protecting them from fungi (such as yeast and mold) and bacteria.It can also be used to reduce or avoid the amount of preservatives in cosmetic compositions, because the amount of such preservatives is reduced or avoided and still maintains antimicrobial properties.

[0005] Thus, in a first embodiment, the present invention provides a method for the preparation of phytantriol and C 4~6 The present invention relates to topical compositions comprising alkylglycerins.

[0006] In a second embodiment, the present invention provides a method for the preparation of phytantriol and C 4~6 Use of mixtures of alkyl glycerols as synergistic antimicrobial mixtures (preservative boosters).

[0007] In a third embodiment, the present invention provides a method for the preparation of phytantriol and C 4~6 The present invention relates to the use of mixtures of alkyl glycerols as antimicrobial agents, i.e. as agents exhibiting antimicrobial activity.

[0008] In particular, the present invention relates to phytantriol and C 4~6 The use of the mixture of alkylglycerins as an antifungal and / or antibacterial agent, in particular as an agent to kill and / or inhibit the growth of fungi, particularly yeasts or molds, and / or bacteria (gram positive and / or gram negative), most preferably Escherichia Coli (E. Coli), Pseudomonas aeruginosa, (P. aeruginosa), Staphylococcus aureus (S. aureus), Aspergillus brasiliensis (A. brasiliensis), and / or Candida albicans (C. albicans), and mixtures thereof.

[0009] In a further embodiment, the present invention relates to a method for killing and / or inhibiting the growth of microbial cells, in particular fungi such as yeasts and / or molds, and / or bacterial cells (most particularly E. coli, P. aeruginosa, S. aureus, A. brasiliensis, and / or C. albicans, and mixtures thereof), comprising treating said microbial cells with phytantriol and C. 4~6 The method includes contacting the alkyl glycerol with a mixture of alkyl glycerols.

[0010] Phytantriol [CAS: 74563-64-7] is a colorless to pale yellow viscous liquid with the chemical name 3,7,11,15-tetramethyl-hexadecane-1,2,3-triol. Phytantriol is commercially available, for example, from DSM Nutritional Products Ltd, Kaiseraugst.

[0011] C 4~6 The term alkylglycerin refers to linear and cyclic C alkylglycerins such as butylglycerin [CAS 624-52-2], pentylglycerin [CAS 22636-32-4], hexylglycerin [CAS 10305-38-1], cyclobutylglycerin, cyclopentylglycerin and cyclohexylglycerin [CAS:10305-41-6], hexylglycerin (also known as 3-(hexyloxy)-1,2-propanediol) and cyclohexylglycerin (also known as 3-(cyclohexyloxy)-1,2-propanediol). 4~6 These are particularly preferred. Most preferred C in all embodiments of the present invention 4~6 The alkyl glycerin is hexyl glycerin. 4~6 Alkylglycerols are commercially available, for example, from Adeka Corporation, Japan.

[0012] As used herein, the term "antimicrobial activity" (or "antimicrobial effect") refers to the ability of a compound to inhibit the activity of microbial cells, such as, in particular, bacterial and fungal cells (especially molds and / or yeasts) (e.g., P. acnes, S. epidermis, M. furfur, A. brasiliensis, E. coli, P. aeruginosa, S. aureus, A. erythrocytes, and / or cerebrospinal fluids, such as, for example, P. acnes, S. epidermis, M. furfur, A. brasiliensis, E. coli, P. aeruginosa, S. aureus, A. erythrocytes, and / or cerebrospinal fluids, such as, for example, P. erythrocytes ... By "antimicrobial activity" is meant the ability to kill and / or inhibit the growth of A. brasiliensis, and / or C. albicans, and mixtures thereof, however preferably E. Coli, P. aeruginosa, S. aureus, A. brasiliensis, and / or C. albicans, and mixtures thereof.

[0013] In all embodiments of the invention, the topical composition preferably comprises phytantriol in an amount of at least 0.005% by weight. More preferably, the amount of phytantriol is chosen in the range of about 0.01% to 5% by weight, more preferably in the range of about 0.05% to 3% by weight, most preferably in the range of 0.1% to 2% by weight. Further suitable ranges include 0.1% to 1.5% by weight or 0.1% to 1% by weight, relative to the total weight of the composition.

[0014] In all embodiments of the present invention, the topical composition preferably comprises an amount (in total) of C selected in the range of about 0.01% to about 5% by weight, preferably in the range of 0.1% to 4% by weight, most preferably in the range of 0.25% to 3% by weight, based on the total weight of the composition. 4~6 Further suitable ranges include 0.25% to 2% by weight and 0.3% to 1% by weight.

[0015] In all embodiments of the present invention, the C 4~6The weight ratio (w / w) of alkyl glycerin is preferably selected in the range of 5:1 to 1:5, such as in the range of 2.5:1 to 1:2.5, for example, most preferably in the range of 1.5:1 to 1:1. In all embodiments of the present invention, most preferably 4~6 The alkyl glycerol may be present in excess, i.e., in an amount greater than the amount of phytantriol, e.g., a weight ratio of greater than 1, more preferably at least 1.25 (i.e., 1 part phytantriol to 1 part C 4~6 Used in combination with 1.25 parts alkyl glycerin.

[0016] Phytantriol and C 4~6 To take advantage of the synergistic antimicrobial activity of the mixture of alkylglycerols, they can be used in a number of formulations or applications, such as, for example, cosmetic or pharmaceutical compositions, medicines, or household products.

[0017] On the one hand, the use according to the invention may be a technical use, such as for example to reduce or prevent microbial growth in a topical composition, in order to improve its shelf life and / or storage stability.

[0018] On the other hand, phytantriol and C 4~6 The use of the mixture of alkylglycerols according to the invention can be in a cosmetic or pharmaceutical sense. A pharmaceutical use can be, for example, in the case of a specific antimicrobial therapy. A cosmetic use can be, for example, in the maintenance of healthy skin homeostasis and / or in the balancing of the skin microflora.

[0019] Phytantriol and C 4~6 The mixture of alkylglycerins (or a topical composition comprising said mixture according to the invention) can also be used for the treatment and / or prevention of pathological skin conditions such as dermatitis and / or acne by maintaining healthy skin homeostasis and / or by balancing the skin microflora, e.g., without being bound by theory, by avoiding the (excessive) proliferation of pathological microorganisms.

[0020] In all embodiments of the present invention, the methods and uses according to the invention are preferably for technical and / or cosmetic (non-therapeutic) purposes, most preferably for technical (i.e. preservative) purposes.

[0021] However, the present invention also relates in another aspect to a topical composition according to the present invention for use in the treatment and / or prevention of pathological skin conditions, such as dermatitis and / or acne, by maintaining healthy skin homeostasis and / or balancing the skin microbiota, said method preferably comprising the step of contacting the skin and / or scalp with said topical composition.

[0022] The topical compositions according to the invention are preferably cosmetic or pharmaceutical compositions, which are intended to be applied topically to mammalian keratinous tissue, in particular to the human skin or the human scalp and hair.

[0023] The term "cosmetic composition" as used in this application refers to cosmetic compositions as defined in the "Kosmetika" section of Rompp Lexikon Chemie, 10th edition 1997, Georg Thieme Verlag Stuttgart, New York, and in A. Domsch, "Cosmetic Compositions", Verlag für chemische Industrie (ed. H. Ziolkowsky), 4 th It refers to the cosmetic compositions disclosed in the 1992 edition.

[0024] The cosmetic or pharmaceutical composition according to the invention preferably further comprises a physiologically acceptable medium, i.e. a medium that is compatible with keratinous materials such as the skin, mucous membranes and keratinous fibers. Preferably, the physiologically acceptable medium is a cosmetically or pharma- ceutically acceptable carrier.

[0025] The term cosmetically or pharma- ceutically acceptable carrier refers in particular to all carriers and / or excipients and / or diluents customarily used in cosmetic compositions, such as oils (cosmetic oils), water, surfactants, emulsifiers, thickeners, etc.

[0026] Topical compositions according to the invention generally contain phytantriol and C in the amounts indicated herein. 4~6 The alkyl glycerin is prepared by mixing with a suitable carrier.

[0027] The exact amount of carrier is phytantriol and C 4~6 It will depend on the actual level of alkylglycerin and any other optional ingredients that one of skill in the art would classify as distinct from a carrier (eg, other active ingredients).

[0028] In an advantageous embodiment, the cosmetic or pharmaceutical composition according to the present invention comprises from about 50% to about 99%, preferably from about 60% to about 98%, more preferably from about 70% to 98%, for example in particular from about 80% to about 95%, of a carrier, based on the total weight of the cosmetic composition.

[0029] In a particularly advantageous embodiment, the carrier further comprises at least 40% by weight, more preferably at least 50% by weight, most preferably at least 55% by weight water, such as especially from about 55 to about 90% by weight water.

[0030] The compositions of the present invention (including the carrier) may contain conventional adjuvants and additives such as preservatives / antioxidants, fatty substances / oils, organic solvents, silicones, thickeners, emollients, emulsifiers, antifoaming agents, aesthetic ingredients such as fragrances, surfactants, fillers, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidifying or basifying agents, dyes, colorants / colorants, abrasives, absorbents, chelating and / or sequestering agents, essential oils, skin sensates, astringents, pigments, or any other ingredient normally formulated in such compositions.

[0031] According to the present invention, the composition according to the present invention can also contain other cosmetic active ingredients that are conventionally used in cosmetic or pharmaceutical compositions.Exemplary active ingredients include skin whitening agents; UV filters, hyperpigmentation treatment agents; inflammation prevention or reduction agents; firming, moisturizing, analgesic and / or nutritional supplements, and agents for improving elasticity and skin barrier.

[0032] Examples of cosmetic excipients, diluents, adjuvants, additives and active ingredients commonly used in the skin care industry and suitable for use in the cosmetic compositions of the present invention can be found, for example, but are not limited to, in the International Cosmetic Ingredient Dictionary & Handbook of the Personal Care Product Council (http: / / www.personalcarecouncil.org / ), accessible online at INFO BASE (http: / / online.personalcarecouncil.org / jsp / Home.jsp).

[0033] The required amounts of active ingredients as well as excipients, diluents, adjuvants, additives, etc. can be readily determined by one skilled in the art based on the desired product form and application. Additional ingredients can be added to the oil phase, the aqueous phase, or separately, as deemed appropriate.

[0034] The cosmetically active ingredients useful herein can in some cases provide more than one benefit or act by more than one mechanism of action.

[0035] Naturally, the skilled artisan will select the above-mentioned optional additional components, adjuvants, diluents and additives, and / or their amounts, taking care that the advantageous properties inherently associated with the combination according to the invention are not adversely affected, or are not substantially affected, by the envisaged addition or additions.

[0036] Preferably, the cosmetic or pharmaceutical composition according to the invention is in the form of a suspension or dispersion in a solvent or fatty substance, or in the form of an emulsion or microemulsion (in particular O / W or W / O), a PIT emulsion, a nanoemulsion, a multiple emulsion (for example O / W / O or W / O / W), a Pickering emulsion, a hydrogel, a lipogel, a single- or multiphase solution or a vesicle dispersion.

[0037] The cosmetic or pharmaceutical composition according to the invention may be in the form of a liquid, a lotion, a thickened lotion, a gel, a cream, a milk, an ointment or a paste.

[0038] The cosmetic or pharmaceutical composition according to the present invention has a pH in the range of 3 to 10, preferably in the range of 3 to 8, most preferably in the range of 3 to 7.5. The pH is adjusted by methods known to those skilled in the art, for example by using an acid, such as a hydroxy acid, including glycolic acid, lactic acid, malic acid, citric acid and tartaric acid, or a base, such as sodium hydroxide, or potassium hydroxide, or ammonium hydroxide, or mixtures thereof.

[0039] Preferably, in the composition according to the invention, the acid (if present) is used in an amount of at least 0.0001% by weight, such as in an amount of 0.01 to 1% by weight, in particular in an amount of 0.01 to 0.5% by weight.

[0040] The cosmetic composition according to the invention advantageously comprises an additional preservative or preservative booster. Particularly suitable preservatives or preservative boosters in all embodiments of the invention are benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, caprylhydroxamic acid, alcohol, alcohol denato, hydroxyacetophenone, caprylyl glycol, pentylene glycol, 1,2-hexanediol, decylene glycol, monoglycerides such as glyceryl laurate, propylene glycol caprylate, propylene glycol heptanoate and mixtures thereof. The preservatives and / or preservative boosters, if present, are preferably used in an amount of 0.01 to 2% by weight, more preferably 0.05 to 1.5% by weight, most preferably 0.1 to 1.0% by weight, relative to the total weight of the composition.

[0041] More preferably, the topical composition according to the present invention does not contain any of the following: parabens, benzethonium chloride, piroctone olamine, lauroyl arginate, methylisothiazolinone, chloromethylisothiazolinone, bronopol, benzalkonium chloride, formaldehyde releasing compounds, salicylic acid, triclosan, DMDM ​​hydantoin, chlorphenesin and IPBC (iodopropynyl butylcarbamate).

[0042] The cosmetic composition according to the invention is in particular a skin care agent, a functional agent and / or a hair care agent, such as most in particular a skin care agent or a hair care agent.

[0043] Examples of skin care agents are, inter alia, photoprotectants (sunscreens), anti-aging agents, photoaging treatments, body oils, body lotions, body gels, treatment creams, skin protective ointments, moisturizers such as moisturizing gels or moisturizing sprays, face and / or body moisturizers, and skin lightening agents.

[0044] Examples of high-performance agents include, but are not limited to, cosmetic compositions containing active ingredients such as hormones, vitamins, vegetable extracts, anti-aging agents, and / or antimicrobial (antibacterial or antifungal) agents.

[0045] Examples of hair care agents which may be mentioned that are suitable according to the invention are shampoos, hair conditioners (also called hair rinses, hair dressing compositions, hair tonics, hair regeneration compositions, hair lotions, water wave lotions, hair sprays, hair creams, hair gels, hair oils, hair pomades or hair brilliantins. These are therefore always preparations which are applied to the hair and scalp for a relatively short or relatively long period of time, depending on the actual purpose for which they are used.

[0046] When the hair care agents according to the invention are supplied as shampoos, they may be in the form of clear liquids, opaque liquids (with pearlescent effect), creams, gel-like forms or powders or tablets, and aerosols. The surfactant raw materials on which these shampoos are based may be anionic, cationic, nonionic and amphoteric in nature and may also be present in combination with these substances.

[0047] Examples of anionic surfactants suitable for incorporation into shampoo formulations according to the invention include C 10~20These include alkyl and alkylene carboxylates, alkyl ether carboxylates, fatty alcohol sulfates, fatty alcohol ether sulfates, alkyl amide sulfates and sulfonates, fatty acid alkylolamide polyglycol ether sulfates, alkane and hydroxyalkane sulfonates, olefin sulfonates, acyl esters of isothionates, alpha-sulfo fatty acid esters, alkyl benzene sulfonates, alkyl phenol glycol ether sulfonates, sulfosuccinates, mono- and diesters of sulfosuccinic acid, fatty alcohol ether phosphates, protein-fatty acid condensation products, alkyl monoglyceride sulfates and sulfonates, alkyl glyceride ether sulfonates, fatty acid methyl taurides, fatty acid sarcosinates, and sulforicinolates. These compounds and mixtures thereof are used in the form of their water-soluble or water-dispersible salts, such as sodium, potassium, magnesium, ammonium, mono-, di- and triethanolammonium, and similar alkylammonium salts.

[0048] Examples of suitable cationic surfactants include: Ji (C 10 ~C 24 alkyl)dimethylammonium chloride or bromide, preferably di(C 12 ~C 18 Alkyl)-dimethylammonium chloride or bromide;C 10 ~C 24 -Alkyldimethylethylammonium chloride or bromide; C 10 ~C 24 -Alkyltrimethylammonium chloride or bromide, preferably cetyltrimethylammonium chloride or bromide and C 20 ~C 24 -Alkyltrimethylammonium chloride or bromide; C 10 ~C 24 4-Alkyldimethylbenzylammonium chloride or bromide, preferably C 12 ~C 18-Alkyldimethylbenzylammonium chloride;N-(C 12 ~C 18 -alkyl)pyridinium chloride or bromide, preferably N-(C 12 ~C 16 -alkyl)pyridinium chloride or bromide;N-(C 12 ~C 18 -alkyl)isoquinolinium chloride, bromide or monoalkyl sulfate;N-(C 12 ~C 18 N-(C-alkyloxy)pyridinium chloride 12 ~C 18 -alkyl)-N-methylmorpholinium chloride, bromide or monoalkyl sulfate;N-(C 12 ~C 18 -alkyl)-N-ethylmorpholinium chloride, bromide or monoalkyl sulfate;C 16 ~C 18 -alkylpentaoxethylammonium chloride; isobutylphenoxyethoxyethyldimethylbenzylammonium chloride; salts of N,N-diethylaminoethylstearylamide and oleylamide with hydrochloric acid, acetic acid, lactic acid, citric acid and phosphoric acid; quaternary ammonium salts such as N-acylamidoethyl-N,N-diethyl-N-methylammonium chloride, bromide or monoalkyl sulfate, and N-acylaminoethyl-N,N-diethyl-N-benzylammonium chloride, bromide or monoalkyl sulfate, in which the acyl group is preferably a stearyl group or an oleyl group.

[0049] Examples of suitable nonionic surfactants which can be used as cleaning materials include fatty alcohol ethoxylates (alkyl polyethylene glycols); alkylphenol polyethylene glycols; alkyl mercaptan polyethylene glycols; fatty amine ethoxylates (alkylamino polyethylene glycols); fatty acid ethoxylates (acyl polyethylene glycols); polypropylene glycol ethoxylates (Pluronic); fatty acid alkylolamides (fatty acid amide polyethylene glycols); sucrose esters; sorbitol esters and polyglycol ethers.

[0050] Examples of amphoteric surfactants that can be added to shampoos include N-(C 12 ~C 18 -alkyl)-beta-aminopropionates and N-(C 12 ~C 18 -alkyl)-beta-iminodipropionates; N-acylamidoalkyl-N,N-dimethylacetobetaines, preferably N-(C 18 -acyl)amidopropyl-N,N-dimethylacetobetaine;C 12 ~C 18 -alkyldimethylsulfopropyl betaines; imidazoline-based amphoteric surfactants (trade names: Miranol®, Steinapon®), preferably the sodium salt of 1-(β-carboxymethyloxyethyl)-1-(carboxymethyl)-2-laurylimidazolinium; amine oxides, e.g. C 12 ~C 18 -Alkyl dimethylamine oxide, fatty acid amide alkyl dimethylamine oxide.

[0051] The hair care agents according to the invention may also contain further additives customary in hair care, such as fragrances, colorants, which also dye or color the hair at the same time, solvents, opacifiers and pearlescent agents, for example esters of fatty acids with polyols, magnesium and zinc salts of fatty acids, copolymer-based dispersions, sodium chloride, potassium chloride and ammonium chloride, sodium sulfate, fatty acid alkylolamides, cellulose derivatives, natural gums, but also plant extracts, gelatins on a natural or synthetic basis, collagen hydrolysates, protein derivatives such as polypeptides, eggs. They may further comprise thickeners such as yellow, lecithin, lanolin and lanolin derivatives, fats, oils, fatty alcohols, silicones, deodorants, substances with antimicrobial activity, substances with antiseborrheic activity, substances with keratolytic and keratinogenic action, for example sulfur, salicylic acid and enzymes, as well as further antidandruff agents such as olamine, climbazole, zinc pyrithione, ketoconazole, salicylic acid, sulfur, tar preparations, undecenoic acid derivatives, nettle, extracts of rosemary, cottonwood, birch, walnut, willow bark and / or arnica.

[0052] The topical cosmetic composition according to the invention is advantageously an O / W emulsion, a W / O emulsion and / or a gel, such as a shower gel.

[0053] Furthermore, the topical composition according to the invention in the form of an O / W emulsion, a W / O emulsion and / or a gel is a skin care agent intended for the treatment of acne or for the maintenance of healthy skin homeostasis and / or for the maintenance of the skin microflora balance.

[0054] The O / W emulsion according to the present invention comprises (i) phytantriol in an amount selected in the range of about 0.01 to 2% by weight, preferably in the range of 0.05 to 1.5% by weight, and most preferably in the range of 0.1 to 1% by weight, based on the total weight of the composition; (ii) C in an amount selected in the range of about 0.01 to about 2% by weight, preferably in the range of 0.1 to 1.5% by weight, and most preferably in the range of 0.1 to 1% by weight, based on the total weight of the composition. 4~6Alkyl glycerin, (iii) water, and (iv) glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, salts of stearic acid, polyglyceryl-3-methylglycose distearate, ceteareth-20, steareth-2, steareth-12, PEG-40 stearate, cetyl phosphate (Amphisol® A), diethanolamine cetyl phosphate (Amphisol® DEA), potassium cetyl phosphate (Amphisol® K), etc. It is advantageous to include at least one O / W- or Si / W-emulsifier selected from the list of phosphate esters and their salts, sodium cetearyl sulfate, sodium oleate glyceryl phosphate, hydrogenated vegetable glyceride phosphate, sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, lauryl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate and hydrated polyisobutene, and mixtures thereof. Also, one or more synthetic polymers may be used as emulsifiers, such as PVP eicosene copolymer, acrylates / C10-3o alkyl acrylate crosspolymer, acrylates / steareth-20 methacrylate copolymer, PEG-22 / dodecyl glycol copolymer, PEG-45 / dodecyl glycol copolymer, and mixtures thereof. In certain preferred embodiments, the O / W-emulsifier is selected from the group of cetyl phosphates, such as in particular potassium cetyl phosphate (commercially available as Amphisol® K), glyceryl stearate (and) PEG 100 stearate (commercially available as Arlacel® 165) and / or polyalkylene glycol ethers, such as in particular laureth-35 (lauryl alcohol with 35 EO units; commercially available as Brij® 35). The at least one O / W emulsifier is preferably used in an amount of about 0.001 to 10% by weight, more preferably in an amount of 0.1 to 7% by weight, relative to the total weight of the composition.Furthermore, the cosmetic composition in the form of an O / W emulsion advantageously contains at least one co-emulsifier selected from the list of alkyl alcohols, such as, but not limited to, cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol (Lanet® O), stearyl alcohol (Lanet® 18), behenyl alcohol (Lanet® 22), glyceryl monostearate, glyceryl myristate (Estol® 3650), hydrogenated coco-glycerides (Lipocire Na10) and mixtures thereof.

[0055] The W / O emulsion according to the present invention comprises: (i) phytantriol in an amount selected in the range of 0.01 to 2% by weight, preferably in the range of 0.05 to 1.5% by weight, and most preferably in the range of 0.1 to 1% by weight, relative to the total weight of the composition; (ii) C in an amount selected in the range of about 0.01 to about 2% by weight, preferably in the range of 0.1 to 1.5% by weight, and most preferably in the range of 0.1 to 1% by weight, relative to the total weight of the composition; 4~6Advantageously, the emulsion comprises at least one W / O or W / Si emulsifier selected from the list of: alkylglycerin, (iii) water, and (iv) polyglyceryl-2-dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, cetyl dimethicone copolyol, polyglyceryl-3 diisostearate polyglycerol ester of oleic acid / isostearic acid, polyglyceryl-6 hexalicinoleate, polyglyceryl-4-oleate, polyglyceryl-4 oleate / PEG-8 propylene glycol cocoate, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallowate, potassium castorate, sodium oleate, and mixtures thereof. Further suitable W / Si emulsifiers are lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, and / or PEG-9 polydimethylsiloxyethyl dimethicone, and / or cetyl PEG / PPG-10 / 1 dimethicone, and / or PEG-12 dimethicone crosspolymer, and / or PEG / PPG-18 / 18 dimethicone. The at least one W / O emulsifier is preferably used in an amount of about 0.001 to 10% by weight, more preferably 0.2 to 7% by weight, relative to the total weight of the composition.

[0056] The gel according to the present invention comprises (i) phytantriol in an amount selected in the range of 0.01 to 2% by weight, preferably in the range of 0.05 to 1.5% by weight, and most preferably in the range of 0.1 to 1% by weight, based on the total weight of the composition; (ii) C in an amount selected in the range of about 0.01 to about 2% by weight, preferably in the range of 0.1 to 1.5% by weight, and most preferably in the range of 0.1 to 1% by weight, based on the total weight of the composition. 4~6Advantageously, the composition comprises an alkyl glycerin, (iii) water, and (iv) at least one water-soluble thickener. Such water-soluble thickeners are well known to those skilled in the art and are listed, for example, in "Handbook of Water-soluble Gums and Resins" by Robert L. Davidson, Mc Graw Hill Book Company (1980). Particularly suitable water-soluble thickeners are selected from the group consisting of polyacrylic acids (for example commercially available under the trade name Carbomer or Carbopol®), homopolymers of 2-acrylamido-2-methylpropanesulfonic acid (for example commercially available as Rheothik® 11-80), acrylate copolymers (for example commercially available under the trade name Pemulen® or Aculyn® 33), branched poly(methacryloyloxyethyltrimethylammonium chloride) (INCI name Polyquaternium-37), unmodified guar gum (for example commercially available under the trade name Jaguar), starch or derivatives thereof, and / or hydroxyalkylcellulose. The water-soluble thickeners are preferably used in an amount of about 0.001 to 10% by weight, more preferably 0.2 to 7% by weight, relative to the total weight of the composition.

[0057] Phytantriol C 4~6 It was observed that when added to a topical composition together with an alkylglycerin, the antimicrobial activity was significantly increased. In other words, by adding a synergistic antimicrobial mixture to the composition, the antimicrobial activity can be improved without the use of phytantriol or C. 4~6 Compared to not using alkyl glycerin, i.e., phytantriol or C 4~6 Fewer microbial growths are observed than when alkylglycerol is used alone. Thus, phytantriol is a useful antimicrobial agent, especially in cosmetic compositions. 4~6 It has a synergistic effect on the antimicrobial action of alkylglycerol.

[0058] This therefore indicates that the addition of an effective amount of phytantriol while maintaining the same antimicrobial activity can 4~6 It is also very advantageous in that the amount of alkylglycerin can be reduced.

[0059] Furthermore, the antimicrobial effect has been observed to be particularly pronounced in aqueous systems, which is highly advantageous since it is typically the aqueous phase of the product that is known to be most susceptible to microbial growth.

[0060] In a further aspect, the present invention relates to a method for preventing or slowing microbial degradation of cosmetic compositions, household products, plastics, paper and / or paints, said method comprising administering to said cosmetic compositions, household products, plastics, paper and / or paints phytantriol and C. 4~6 A mixture of alkyl glycerols, (i) from 0.01 to 2% by weight, preferably from 0.05 to 1.5% by weight, and most preferably from 0.1 to 1% by weight, of phytantriol, relative to the total weight of the composition; and (ii) 0.01 to 2% by weight, preferably 0.1 to 1.5% by weight, more preferably 0.1 to 1% by weight, of C based on the total weight of the composition. 4~6 Alkylglycerin in an amount of

[0061] The following examples are provided to further illustrate the compositions and effects of the present invention. These examples are provided for illustrative purposes only and are not intended to limit the scope of the present invention in any way.

[0062] [Example] The evaluation of the preservative properties of cosmetic formulations is based on inoculating the formulations outlined in Table 1 with an adjusted inoculum (prepared from the relevant microbial strain). Thus, 0.2 ml of the adjusted inoculum is added to each formulation, resulting in the inoculation of 1 x 10 4 cfu / ml ~ 1 × 10 7 cfu / ml or g of bacteria, as well as 1×10 2 cfu / ml ~ 1 × 10 6Obtain cfu / ml or g of C. albicans and A. brasiliensis (final concentrations) and mix them thoroughly in the formulation to ensure uniform distribution of the inoculum. Then, store each container containing the inoculated formulation at 22.5 ± 2.5 °C. At each specific sampling interval (initial (T0), 7 days (T7) and 28 days (T28)), take 1 g of the inoculum formulation, prepare dilutions and count the viable microorganisms. Then, for each time and each strain / strain mixture, calculate the mean logarithmic values ​​and show them in Tables 2-6. (Procedure: See ISO 11930, chapters 5.2.-5.6.3.4. (page 3-13)).

[0063] [Table 1]

[0064] [Table 2]

[0065] As can be seen from the table above, the combination of phytantriol and hexylglycerin shows a synergistic effect against Candida albicans. This combination also works better than the combination of phytantriol and ethylhexylglycerin (a well-known preservative booster).

[0066] [Table 3]

[0067] [Table 4]

[0068] [Table 5]

[0069] As can be recalled from Tables 3-5, the combination of phytantriol and hexylglycerin at different concentration levels / weight ratios shows a synergistic effect against Aspergillus brasiliensis. This combination works better than the combination of phytantriol and ethylhexylglycerin, a well-known preservative booster.

[0070] [Table 6]

[0071] As can be recalled from Table 6, the combination of phytantriol and hexylglycerin also shows a synergistic effect against bacteria, the combination performing better than the combination of phytantriol and ethylhexylglycerin (a well-known preservative booster).

Claims

1. Phytantriol and C ４～６ alkylglycerin, the C4-6 alkylglycerin being hexylglycerin; the amount of phytantriol being chosen ranging from 0.01% to 5% by weight relative to the total weight of the composition; the amount of said C 4-6 alkyl glycerol being chosen in the range from 0.01% to 5% by weight relative to the total weight of the composition; A topical composition wherein the weight ratio of said C 4-6 alkyl glycerin to phytantriol is selected in the range of 5:1 to 1:

5.

2. 2. The topical composition according to claim 1, wherein the amount of phytantriol is chosen in the range from 0.05% to 3% by weight relative to the total weight of the composition.

3. The topical composition according to claim 1, wherein the amount of phytantriol is chosen in the range from 0.1% to 2% by weight relative to the total weight of the composition.

4. Said C ４～６ A topical composition according to any one of claims 1 to 3, wherein the amount of alkylglycerin is chosen in the range from 0.1% to 4% by weight relative to the total weight of the composition.

5. Said C ４～６ A topical composition according to any one of claims 1 to 3, wherein the amount of alkylglycerin is chosen in the range from 0.25% to 3% by weight relative to the total weight of the composition.

6. Said C ４～６ A topical composition according to any one of claims 1 to 5, wherein the weight ratio of alkylglycerin to phytantriol is selected in the range of 2.5:1 to 1:2.

5.

7. Said C ４～６ A topical composition according to any one of claims 1 to 5, wherein the weight ratio of alkylglycerin to phytantriol is selected in the range of 1.5:1 to 1:

1.

8. The topical composition according to any one of claims 1 to 7, wherein the composition is a cosmetic composition or a pharmaceutical composition.

9. 9. The topical composition of claim 8, wherein the composition is a shampoo, a hair conditioner, an O / W emulsion, a W / O emulsion or a gel.

10. The topical composition of any one of claims 1 to 9, wherein the composition comprises water and at least one agent selected from the group consisting of surfactants, emulsifiers, thickeners, and oils.

11. A non-therapeutic method of treating the skin and / or scalp, comprising the step of contacting said skin and / or scalp with a topical composition according to any one of claims 1 to 10.

12. Phytantriol and C to reduce or prevent microbial growth during storage of the topical composition according to any one of claims 1 to 10. ４～６ Use of a mixture of alkyl glycerins.

13. 13. Use according to claim 12 for improving the shelf life and / or storage stability of the composition.

14. A method for preventing or retarding microbial degradation of a cosmetic composition, comprising: ４～６ A mixture of alkyl glycerols, (i) from 0.01 to 2% by weight of phytantriol relative to the total weight of the composition; and (ii) 0.01 to 2% by weight of C based on the total weight of the composition ４～６ Alkylglycerin adding in an amount of The C4-6 alkyl glycerin is hexyl glycerin; A method wherein the weight ratio of said C 4-6 alkyl glycerin to phytantriol is selected in the range of 5:1 to 1:

5.

15. The method according to claim 14, wherein the amount of phytantriol ranges from 0.05 to 1.5% by weight relative to the total weight of the composition.

16. The method according to claim 14, wherein the amount of phytantriol ranges from 0.1 to 1% by weight relative to the total weight of the composition.

17. Said C ４～６ The method according to any one of claims 14 to 16, wherein the amount of alkylglycerin ranges from 0.1 to 1.5% by weight relative to the total weight of the composition.

18. Said C ４～６ The method according to any one of claims 14 to 16, wherein the amount of alkylglycerin ranges from 0.1 to 1% by weight relative to the total weight of the composition.

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