Novel pesticide combinations

Abstract

To provide a combination of actives that allows for broader disease control spectra and improved plant health that combines curative and preventive actives and has a lower dosage.SOLUTION: The present invention provides a combination comprising at least one diamide insecticide, and at least a silicic acid-based plant health promoting additive, and a composition comprising the same.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a combination comprising a fungicidal active compound and a diamide insecticide in combination with a plant health promoter, which is particularly suitable for controlling nuisance pests / animal pests (e.g. insects, mites and / or nematodes) and nuisance plant pathogenic fungi. [Background technology]

[0002] Insecticides are substances used to kill insects. Insecticides include ovicides and larvicides, which are used against insect eggs and larvae, respectively.

[0003] Diamide insecticides are a relatively new group of insecticides that include the highly potent lepidoptericides flubendiamide and chlorantraniliprole and its analogue cyantraniliprole. The development of diamides is described in the following publication: Pest Manag Sci. 2013 Jan;69(1):7-14.

[0004] Chlorantraniliprole and cyantraniliprole are anthranilic acid diamide insecticidal compounds that act against Ca 2+ By targeting and disrupting the balance and ryanodine receptors, they show larvicidal activity as orally ingested toxicants. Fungicides are essential and important tools used by farmers to control diseases and improve yield and crop quality. Over the years, a variety of fungicides have been developed with many desirable attributes (e.g., specificity, systemic, curative and repellent action, and high activity at low doses).

[0005] Various other classes of fungicides are also known in the art, such as quinone external inhibitors (QoIs), ergosterol biosynthesis inhibitors, fungicides acting at multiple sites, and fungicides acting at mitosis.

[0006] Dithiocarbamates are known in the art as multi-site fungicides. These fungicides are used in over 70 crops for broad-spectrum disease control. Mancozeb is particularly important in controlling fast-spreading destructive diseases (e.g., Phytophthora infestans, Venturia inaequalis, etc.). Dithiocarbamate fungicides (especially mancozeb) are particularly useful in disease control because of their broad-spectrum activity, high tolerance by crop plants, and general usefulness in controlling fungal plant diseases that cannot be controlled by active compounds that act only at a single target site in the fungus.

[0007] A variety of plant health promoters are known in the art (e.g., fertilizers, biologicals, and plant additives that can promote growth and improve plant yields). Silica is the second most abundant element in the earth's crust. A variety of studies have been conducted that show the importance of silica in plant growth. There are also studies that show that silica is incorporated in the same amount as any other known micronutrient (Role of Orthosilicic Acid (OSA) Based Formulation in Improving Plant Growth and Development, Jain et.al, Silicon (2016)). A large number of silica-based fertilizers and plant growth promoters are known in the art. However, none of them are mixed with a combination of fungicides and insecticides.

[0008] In US 7696232 B2 there is disclosed a composition comprising chlorantraniliprole and other active substances such as fungicides.

[0009] Therefore, the field needs a combination of anthranilamide insecticide compounds with fungicides and plant health promoters to not only improve the spectrum, but also to help further promote plant health and improve yield.Since the reduced tolerance of crops leads to lower application rates and the observed increase in resistance, the combination of active substances that combines curative and preventive active substances and allows a broader disease control spectrum and improved plant health at low dosages is needed. Summary of the Invention [Problem to be solved by the invention]

[0010] Thus, according to embodiments of the present invention, one or more of the above problems may be ameliorated.

[0011] Thus, embodiments of the present invention may provide combinations of insecticides, fungicides and plant health promoters that are more effective than either of the individual active compounds used alone.

[0012] Another object of the present invention is to provide a combination of an insecticide, a fungicide and a plant health promoter that allows for improved greening of the crop to which it is administered.

[0013] Another object of the present invention is to provide a combination which, when applied to the plant's habitat, allows for an increase in crop yield.

[0014] It is yet another object of the present invention to provide a combination which reduces fungal disease incidence in the crop to which it is applied.

[0015] Another object of the present invention is to provide a combination that achieves increased yields in the crops to which it is applied.

[0016] Another object of the present invention is to provide a combination which allows for improved insecticidal activity.

[0017] Another object of the present invention is to provide a combination which improves the protection of plants from attack or infestation by insects, mites or nematodes.

[0018] Another object of the present invention is to provide a synergist for anthranilamide insecticides.

[0019] Some or all of the above and other objects of the present invention may be accomplished by the inventions described hereinafter. [Means for solving the problem]

[0020] Thus, according to an aspect of the invention, there may be provided a combination comprising: at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; and at least one plant health promoter.

[0021] According to another aspect of the present invention, there may be provided a composition comprising: at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, and tetraniliprole; at least one plant health promoter; and at least one pesticidally acceptable excipient.

[0022] According to another aspect of the invention, there may be provided a combination comprising: at least one multi-site fungicide; at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; and at least one plant health promoter.

[0023] According to another aspect of the present invention, there may be provided a composition comprising: at least one multi-site fungicide; at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; at least one plant health promoter; and at least one pesticidally acceptable excipient.

[0024] According to another aspect of the invention, there may be provided a combination comprising: at least one dithiocarbamate fungicide; at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; and at least one plant health promoter.

[0025] According to another aspect of the present invention, there may be provided a composition comprising: at least one dithiocarbamate fungicide; at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; at least one plant health promoter; and at least one pesticidally acceptable excipient.

[0026] According to yet another aspect of the present invention, there may be provided a combination comprising: at least one multi-site fungicide; at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; at least one plant health promoter; and at least a third pesticide active.

[0027] According to yet another aspect of the present invention, there may be provided a composition comprising: at least one multi-site fungicide; at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole; at least one plant health promoter; at least a third pesticidal active; and at least one pesticidally acceptable excipient. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0028] The term "disease control" as used herein refers to the control and prevention of disease. Examples of control effects include deviations from naturally occurring events such as the disappearance, delay, and reduction of fungal disease. The term "plant" refers to all physical parts of a plant (e.g., seeds, seedlings, saplings, roots, tubers, stems, trunks, leaves, and fruits). The term "locus" of a plant as used herein is intended to include the location where the plant is growing and refers to the location where the plant propagation material of the plant is sown or placed in the soil. The term "plant propagation material" is understood to refer to the reproductive parts of a plant (e.g., seeds, vegetative material (e.g., cuttings or tubers, roots, fruits, tubers, bulbs, rhizomes, and plant parts, sprouted plants, and young plants that will be transplanted after germination or emergence from the soil)). These seedlings can be transplanted by total or partial treatment by immersion after protection. The term "agriculturally acceptable amount of an active material" refers to an active material that eliminates or suppresses the plant disease which it is desired to control, in an amount that is not significantly toxic to the plant being treated.

[0029] Surprisingly, it has been found that the insecticidal and / or acaricidal and / or antibacterial, or fungicidal and / or plant-activating and / or yield-enhancing activity of the active compound combinations according to the invention is significantly higher than the sum of the activities of the individual active compounds.

[0030] Surprisingly, it was found that the addition of the plant health promoting additive to the diamide insecticide synergistically enhanced the efficacy of the diamide insecticide, such that the insecticidal activity of the diamide insecticide in the presence of the plant health promoter of the present invention was surprisingly higher than in the absence of the plant health promoter.

[0031] More surprisingly, it has been found that adding a plant health additive to a combination of a multi-site fungicide (preferably a dithiocarbamate fungicide) and a diamide insecticide compound provides surprising and unexpected benefits.Surprisingly, the addition of a plant health additive (e.g., a silicic acid-based additive) in combination with a multi-site fungicide and a diamide insecticide improves efficacy, surprisingly reduces fungal disease occurrence, and improves pest control compared to the efficacy seen only when the diamide insecticide is combined with at least one other fungicide.Furthermore, it has been found that adding a plant health additive to a combination of a multi-site fungicide and a diamide insecticide improves crop greening and increases yield from the crop to which it is applied.

[0032] These surprising benefits of the combinations of the present invention were not observed when the multi-site fungicide (preferably a dithiocarbamate fungicide) was not present in the combination or when the health-promoting additive was not added to the combination, and therefore these surprising benefits of the combinations of the present invention can be attributed to the inclusion in or combination of the dithiocarbamate fungicide and diamide insecticide with the plant health-promoting additive.

[0033] Thus, in an aspect, the present invention provides a combination comprising: (a) at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, and tetraniliprole; (b) At least one silica-based plant health promoting additive.

[0034] In another aspect, the present invention provides a combination comprising: (a) at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, and tetraniliprole; (b) at least one multi-site fungicide; and (c) At least one silica-based plant health promoting additive.

[0035] In one embodiment, the plant health promoting additive according to the present invention is a silicic acid based additive selected from compounds having the general formula: [SiO x (OH) 4-2x ] n

[0036] Such silicic acid may be selected from metasilicic acid (H2SiO3), orthosilicic acid (H4SiO4), disilicic acid (H2Si2O5), and pyrosiliic acid (H6Si2O7), preferably orthosilicic acid, more particularly stabilized orthosilicic acid.

[0037] In one embodiment, the plant health promoting additive is orthosilicic acid.

[0038] In one embodiment the combination of the invention comprises at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole.

[0039] In one embodiment, the diamide insecticide is chlorantraniliprole.

[0040] In one embodiment, the diamide insecticide is cyantraniliprole.

[0041] In one embodiment, the diamide insecticide is flubendiamide.

[0042] In one embodiment, the combination of the present invention comprises a multi-site fungicide.

[0043] In one embodiment, the multi-site fungicide is selected from the group consisting of dithiocarbamates, phthalimides, chloronitriles, inorganic fungicides, sulfamides, bis-guanidines, triazines, quinones, quinoxalines, dicarboxamides and mixtures thereof.

[0044] In one embodiment, the multi-site fungicide is selected from the class of dithiocarbamate fungicides selected from: asamobam, asomate, azithiram, carbamorph, kufuraneb, kuprovam, disulfiram, ferbam, metham, nerbam, tecoram, thiram, urvacid, ziram, dazomet, ethem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.

[0045] In one embodiment, the multi-site fungicide is a phthalimide fungicide selected from captan, captafol and folpet.

[0046] In one embodiment, the multi-site disinfectant is a chloronitrile disinfectant (eg, chlorothalonil).

[0047] In one embodiment, the multi-site fungicide is a sulfamide fungicide selected from dichlofluanid and tolylfluanid.

[0048] In one embodiment, the multi-site fungicide is a bis-guanidine fungicide selected from guazatine and iminoctadine.

[0049] In one embodiment, the multi-site fungicide is a triazine fungicide selected from anilazines.

[0050] In one embodiment, the multi-site fungicide is a quinone fungicide selected from dithianone.

[0051] In one embodiment, the multi-site fungicide is a quinoxaline fungicide selected from quinomethionate and chlorquinox.

[0052] In one embodiment, the multi-site fungicide is a dicarboxamide fungicide selected from fluoroimides.

[0053] In one embodiment, the multi-site fungicide is an inorganic fungicide selected from a copper fungicide (e.g., copper(II) hydroxide, basic copper chloride, copper(II) sulfate, basic copper phosphate, Bordeaux mixture, copper salicylate CH*Cu, cuprous oxide CUO); or sulfur.

[0054] In one embodiment, the combination of the present invention may include at least a second fungicide or insecticide that is different from the multi-site fungicide.

[0055] In one embodiment, the second insecticide is a combination of at least two additional insecticides.Herein, in this embodiment, these insecticides are referred to as the second and third insecticides, respectively.The second and third insecticides are not the same insecticide, but may be a combination of two insecticides from the same class of insecticides.

[0056] In one embodiment, the second and / or third fungicide in the combination of the invention may be individually selected from the following: acetylcholinesterase (AChE) inhibitors, GABA-gated chloride channel blockers, sodium channel modulators, nicotinic acetylcholine receptor (nAChR) competitive modulators, nicotinic acetylcholine receptor (nAChR) allosteric modulators, glutamate-gated chloride channel (GluCl) allosteric modulators, juvenile hormone analogs, chordotonal organ TRPV channel modulators, mite growth inhibitors, fungal disruptors of insect midgut membranes, inhibitors of mitochondrial ATP synthase, uncouplers of oxidative phosphorylation via disruption of the proton gradient, nicotinic acetylcholine receptor (nAChR) channel blockers, inhibitors of chitin biosynthesis, molting disruptors, ecdysone receptor agonists, octopamine receptor agonists, mitochondrial complex electron transport inhibitors, voltage-dependent sodium channel blockers, inhibitors of acetyl-CoA carboxylase, chordotonal organ modifiers, multi-site multi-use insecticides, bioinsecticides and mixtures thereof.

[0057] Thus, in one embodiment, the acetylcholinesterase (AChE) inhibitor (C) may be selected from the group consisting of carbamates (e.g., alanycarb (C1), aldicarb (C2), bendiocarb (C3), benfuracarb (C4), butocarboxim (C5), butoxycarboxim (C6), carbaryl (C7), carbofuran (C8), carbosulfan (C9), ethiofencarb (C9), fenobucarb (C10), formetanate (C11), furathiocarb (C12), isoprocarb (C13), methiocarb (C14), methomyl (C15), metolcarb (C16), oxamyl (C17), pirimicarb (C18), propoxur (C19), thiodicarb (C20), thiofanox (C21), triazamate (C22), trimethacarb (C23), XMC (C24), xylylcarb organophosphates (e.g., acephate (C25), azamethiphos (C26), azinphos-ethyl (C27), azinphos-methyl (C28), cadusafos (C29), chlorethoxyphos (C30), chlorfenvinphos (C31), chlormephos (C32) , Chlorpyrifos (C33), Chlorpyrifos-methyl (C34), Coumaphos (C35), Cyanophos (C36), Demeton-S-methyl (C37), Diazinon (C38), Dichlorvos / DDVP (C39), Dicrotophos (C40), Dimethoate (C41), Dimethylvinphos (C42), Disulfoton (C43), EPN (C44), Ethion (C45), Ethoprophos (C46), Famfur (C47), Fenamiphos (C48), Fenitrothion (C49), Fenthion (C50), Fosthiazate (C51), Heptenophos (C52), Imicyaphos (C53), Isofenphos (C54), Isopropyl O-(methoxyamino-thiophosphoryl) salicylate (C55), Isoxathion (C56), Malathion (C57), Mecarbam (C58), Methamidophos (C59), Methidathion (C60), Mevinphos (C61), Monocrotophos (C62), Naled (C63), Omethoate (C64), Oxydemeton-methyl (C65), Parathion (C66), Parathion-methyl (C67), Phenthoate (C68), Phorate (C69), Phosalone (C70),Phosmet (C71), Phosphamidon (C72), Phoxim (C73), Pirimiphos-methyl (C74), Profenofos (C75), Propetamphos (C76), Prothiofos (C77), Pyraclofos (C78), Pyridafenthion (C79), Quinalphos (C80), Sulfotep (C81), Tebupirimfos (C82), Temephos (C83), Terbufos (C84), Tetrachlorvinphos (C85), Thiometon (C86), Triazophos (C87), Trichlorfon (C87), Vamidothion (C88) and mixtures thereof.

[0058] In one embodiment, suitable acetylcholinesterase (AChE) inhibitors may be selected from: thiodicarb (C20), methomyl (C15), acephate (C25) and quinalphos (C80).

[0059] In another embodiment, the GABA-gated chloride channel blocker may be selected from: chlordane (C89), endosulfan (C90), ethiprole (C91), fipronil (C92) and mixtures thereof.

[0060] A suitable GABA-gated chloride channel blocker may be fipronil (C92).

[0061] In one embodiment, the sodium channel modulating agent may be selected from the following: pyrethroids (e.g., acrinathrin (C93), allethrin (C94), bioallethrin (C95), esdeparethrin (C96), bartholin (C97), bifenthrin (C98), kappa-bifenthrin (C99), bioethanotomerin (C100), brofenvalerate (C101), brofluthrinate (C102), bromethrin (C103), butethrin (C104), chlorempentrin (C105), ciclethrin (C106), cycloprotamine (C107), cycloprotamine (C109), cycloprotamine (C200), cycloprotamine (C201), cycloprotamine (C202), cycloprotamine (C203), cycloprotamine (C204), cycloprotamine (C205), cycloprotamine (C206), cycloprotamine (C207), cycloprotamine (C208), cycloprotamine (C209), cycloprotamine (C210), cycloprotamine (C211), cycloprotamine (C212), cycloprotamine (C213), cycloprotamine (C214), cycloprotamine (C215), cycloprotamine (C216), cycloprotamine (C217), cycloprotamine (C218), cycloprotamine (C219), cycloprotamine (C220), cycloprotamine (C221), cycloprotamine (C222), cycloprotamine (C223), cycloprotamine (C224), cycloprotamine (C225), cycloprotamine (C226), cycloprotamine (C227), cycloprotamine ( Phosphorus (C107), Cyfluthrin (C108), Beta-Cyfluthrin (C109), Cyhalothrin (C110), Gamma-Cyhalothrin (C111), Lambda-Cyhalothrin (C112), Cypermethrin (C113), Alpha-Cypermethrin (C114), Beta-Cypermethrin (C115), Theta-Cypermethrin (C116), Zeta-Cypermethrin (C116), Cyphenothrin (C117), Deltamethrin (C118), Dimefluthrin (C119), Dimethrine (C120), Empenthrin (C121), d-Phansilk Ebbingujuzuhi (C122), Chloroprellethrin (123), Fenfluthrin (C124), Fenpyrithrin (C125), Fenpropathrin (C126), Fenvalerate (C127), Esfenvalerate (C128), Flucythrinate (C129), Fluvalinate (C129), Tau-fluvalinate (C130), Flamethrin (C131), Frethrin (C132), Heptafluthrin (C133), Imiprothrin (C134), Japotrin (C135), Kadethrin (136), Methotrin (C137), Metoflu Torin (C138), epsilon-metofluthrin (C139), momfluorothrin (C140), epsilon-momfluorothrin (C141), permethrin (C142), permethrin (C143), biopermethrin (C144), transpermethrin (C145), fenothrin (C146), prallethrin (C147), profluthrin (C148), proparthrin (C149), permethrin (C150), lenofluthrin (151), meperfluthrin (C152), resmethrin (C153), bioresmethrin (C154),Cysmethrin (C155), Tefluthrin (C156), Kappa-Tefluthrin (C157), Tetrarethrin (C158), Tetramethrin (C159), Tetramethylcyfluthrin (C160), Tralocitrin (C161), Tralomethrin (C162), Trans-cyfluthrin (C163), Valerate (C164), Etofenprox (C165), Flufenprox (C166), Halfenprox (C167), Proturiphenbute (C168), Silafluofen (C169), fluoroxime ((RS)-[1-(4-chlorophenyl)-2-(methylthio)-1-propanone] (EZ)-O-(3-phenoxybenzyl)oxime) (C170), thiofuloximate (C171) or DDT (C172), methoxychlor (C173)), natural pyrethrins (e.g., cinerin-I (C174), cinerin-II (C175), jasmolin-I (C176), jasmolin-II (C177), pyrethrin-I (C178) and pyrethrin-II (C179)) or mixtures thereof.

[0062] Suitable sodium channel modulating agents may be: bifenthrin (C98), kappa-bifenthrin (C99), gamma-cyhalothrin (C111), lambda-cyhalothrin (C112), cypermethrin (C113), alpha-cypermethrin (C114), beta-cypermethrin (C115), theta-cypermethrin (C116), zeta-cypermethrin (C116), fenpropathrin (C126), permethrin (C143) and mixtures thereof.

[0063] In one embodiment, the nicotinic acetylcholine receptor (nAChR) competitive modulator may be selected from: neonicotinoids (e.g., acetamiprid (C180), clothianidin (C181), dinotefuran (C182), imidacloprid (C183), nitenpyram (C184), thiacloprid (C185), thiamethoxam (C186)); sulfoximines (e.g., sulfoxaflor (185)); butenolides (e.g., flupyradifurone (C186)); mesoions (e.g., triflumezopyrim (C186)) and mixtures thereof.

[0064] Suitable nicotinic acetylcholine receptor (nAChR) competitive modulators may be: acetamiprid (C180), clothianidin (C181), imidacloprid (C183), thiacloprid (C185), thiamethoxam (C186), sulfoxaflor (185).

[0065] In one embodiment, the nicotinic acetylcholine receptor (nAChR) allosteric modulator may be selected from: spinosyns (e.g., spinetoram (C187), spinosad (C188)) and mixtures thereof.

[0066] A suitable nicotinic acetylcholine receptor (nAChR) allosteric modulator may be spinosad (C188).

[0067] In one embodiment, a glutamate-gated chloride channel (GluCl) allosteric modulator (e.g., an avermectin selected from: avermectin (C189), emamectin benzoate (C190), lepimectin (C191)) and a milbemycin (e.g., milbemectin (C192), milbemycin A3 (C193), milbemycin A4 (C194), milidiomycin (C195)), and mixtures thereof.

[0068] A suitable glutamate-gated chloride channel (GluCl) allosteric modulator may be avermectin (C189).

[0069] In one embodiment, the juvenile hormone analogue may be selected from: hydroprene (C196), kinoprene (C197), methoprene (C198), fenoxycarb (C199), pyriproxyfen (C200) and mixtures thereof.

[0070] A suitable juvenile hormone analogue may be pyriproxyfen (C200).

[0071] In one embodiment, the versatile non-specific (multi-site) inhibitor insecticide may be selected from the following: methyl bromide, etc., chloropicrin (C201), cryolite (sodium aluminum fluoride) (C202), sulfuryl fluoride (C203), borax (C204), boric acid (C205), disodium octaborate (C206), sodium borate (C207), sodium metaborate (C208), tartar emetic (C209), dazomet (C210), metam (C211) and mixtures thereof.

[0072] In one embodiment, the chordotonal TRPV channel modulator may be selected from: pymetrozine (C212), pyrifluquinazone (C213) and mixtures thereof.

[0073] In one embodiment, the mite growth inhibitor may be selected from: clofentezine (C214), diflovidazine (C215), hexythiazox (C216), etoxazole (C217) and mixtures thereof.

[0074] In one embodiment, the bacterial disruptor of the insect midgut membrane may be selected from: Bacillus thuringiensis subsp. Israelensis (C218), Bacillus thuringiensis subsp. Aizawai (C219), Bacillus thuringiensis subsp. Kurstaki (C219), Bacillus thuringiensis subsp. Tenebrionis (C220), Bt crop proteins (e.g., Cry1Ab (C221), Cry1Ac (C222), Cry1Fa (C223), Cry1A.105 (224), Cry2Ab (C225), Vip3A (C226), mCry3A (C227), Cry3Ab (C228), Cry3Bb (C229), Cry34Ab1 / Cry35Ab1 (C230)), Bacillus sphaericus (C231), etc.

[0075] In one embodiment, the inhibitor of mitochondrial ATP synthase may be selected from: diafenthiuron (C232), azocyclotin (C233), cyhexatin (C234), fenbutatin oxide (C235), propargite (236), tetradifon (C237) and mixtures thereof.

[0076] In one embodiment, the uncoupler of oxidative phosphorylation via proton gradient perturbation may be selected from the following: chlorfenapyr (C238), DNOC (C239), sulfluramide (C240) and mixtures thereof.

[0077] In one embodiment, the nicotinic acetylcholine receptor (nAChR) channel blocker may be selected from: bensultap (C241), cartap hydrochloride (C242), thiocyclam (C243), thiosultap-sodium (C244) and mixtures thereof.

[0078] In one embodiment, the inhibitor of chitin biosynthesis may be selected from: bistrifluron (C245), chlorfluazuron (C246), diflubenzuron (C247), flucycloxuron (C248), flufenoxuron (C249), hexaflumuron (C250), lufenuron (C251), novaluron (C252), noviflumuron (C253), teflubenzuron (C254), triflumuron (C255), buprofezin (C256), and mixtures thereof.

[0079] Suitable inhibitors of chitin biosynthesis may be: novaluron (C252), chlorfluazuron (C246), lufenuron (C251), buprofezin (C256).

[0080] In one embodiment, the molting disruptor may be selected from cyromazine (C257), and the like.

[0081] In one embodiment, the ecdysone receptor agonist may be selected from: chromafenozide (C258), halofenozide (C259), methoxyfenozide (C260), tebufenozide (C261) and mixtures thereof.

[0082] A suitable ecdysone receptor agonist may be selected from methoxyfenozide (C260).

[0083] In one embodiment, the octopamine receptor agonist may be selected from amitraz (C262), and the like.

[0084] In one embodiment, the mitochondrial conjugate electron transport inhibitor may be selected from: hydramethylnon (C263), acequinocyl (C264), fluacrypyrim (C265), bifenazate (C266), fenazaquin (C267), fenpyroximate (C268), pyridaben (C269), pyrimidifen (C270), tebufenpyrad (C271), tolfenpyrad (C272), rotenone (C273), aluminum phosphide (C274), calcium phosphide (C275), phosphine (C276), zinc phosphide (C277), calcium cyanide (C278), potassium cyanide (C279), sodium cyanide (280), cyenopyrafen (C281), cyflumetofen (C282), piflubumid (C283), and mixtures thereof.

[0085] Suitable mitochondrial conjugate electron transport inhibitors may be: bifenazate (C266), fenpyroximate (C268), pyridaben (C269), tebufenpyrad (C270), tolfenpyrad (C271).

[0086] In one embodiment, the voltage-dependent sodium channel blocker may be selected from: indoxacarb (C272), metaflumizone (C273) and mixtures thereof.

[0087] In one embodiment, the inhibitor of acetyl-CoA carboxylase may be selected from: tetrones and tetramic acid derivatives (e.g., spirodiclofen (C274), spiromesifen (C275), spirotetramat (C276) and spiropydione (C277) and mixtures thereof).

[0088] In one embodiment, the chordotonal organ modulating agent-variable target moiety may be selected from flonicamide (C278), and the like.

[0089] In one embodiment, the biopesticide may be selected from the following: botanical insecticides (e.g., Azadirachtin A (C279), Eugenol (C280), Neem Oil (C281), Tousendanin (C282), 1-Cinnamoyl-3-feruloyl-11-hydroxymeriacarpine (C283), Volkensin (C284), d-Limonene (C285), Menthol, (C286) 1,8-Cineole (C287), Citronellal (C288), Eugenol (C289), p-Eugenol-3,8-diol (C290), Thymol (C291), and mixtures thereof).

[0090] In one embodiment, the second bactericide is a combination of at least two bactericides. Herein, in this embodiment, these bactericides are referred to as the second and third bactericides, respectively. The second and third bactericides are not the same bactericide, but may be a combination of two bactericides of the same class of bactericides.

[0091] In one embodiment, the second and / or third fungicide in the combination of the invention may be individually selected from the following: nucleic acid synthesis inhibitors, cytoskeletal and motor protein inhibitors, amino acid and protein synthesis inhibitors, respiratory process inhibitors, signal transduction inhibitors, lipid synthesis and membrane integrity disruptors, sterol biosynthesis inhibitors, melanin synthesis inhibitors, cell wall biosynthesis inhibitors, host plant defense inducers, and / or fungicides with unknown mechanism of action.

[0092] Thus, in one embodiment, the nucleic acid synthesis inhibitor fungicide may be selected from the following: acylalanines (e.g., benalaxyl, benalaxyl-M (chiralaxyl), furalaxyl, metalaxyl, metalaxyl-M (mefenoxam)), oxazolidinones (e.g., oxadixyl), butyrolactones (e.g., ofrace), hydroxy-(2-amino-)pyrimidines (e.g., bupirimate, dimethirimol, ethirimol), isoxazoles (e.g., hymexazole), isothiazolinones (e.g., octhilinone), carboxylic acids (e.g., oxolinic acid).

[0093] In one embodiment, the cytoskeletal and motor protein inhibitors can be: benzimidazoles (e.g., benomyl, carbendazim, fuberidazole, thiabendazole); thiophanates (e.g., thiophanate, thiophanate-methyl); N-phenylcarbamates (e.g., diethofencarb); toluamides (e.g., zoxamide); thiazolecarboxamides (e.g., ethaboxam); phenylureas (e.g., pencycurone), benzamides (e.g., fluopicolide); cyanoacrylates (e.g., phenamacryl).

[0094] In one embodiment, the respiratory process inhibitor fungicide may be selected from the following: pyrimidineamines (e.g., diflumetrim); pyrazole-5-carboxamides (e.g., tolfenpyrad), strobilurins (e.g., azoxystrobin, comoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyraclostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb, and mixtures thereof); oxazolidinediones (e.g., famoxadone); imidazolinones (e.g., fenamidone, don); benzyl-carbamates (e.g., pyribencarb); N-methoxy-(phenyl-ethyl)-pyrazole-carboxamides (e.g., pyrimidineamines (e.g., diflumetrim); cyano-imidazoles (e.g., cyazofamid); sulfamoyl-triazoles (e.g., amisulbrom); dinitrophenylcrotonic acids (e.g., binapacryl, meptyldinocap, dinocap); 2,6-dinitro-anilines (e.g., fluazinam); pyr.-hydrazones (e.g., ferimzone); tri-phenyltin compounds (e.g., fentin acetate), fentin chloride, fentin hydroxide); thiophene-carboxamides (e.g., silthiofam); triazolo-pyridylamines (e.g., amethoctrazine).

[0095] In one embodiment, the amino acid and protein synthesis inhibitor fungicide may be selected from the following: anilino-pyrimidines (e.g., cyprodinil, mepanipyrim, pyrimethanil), antibiotic fungicides (e.g., blasticidin-S, kasugamycin, streptomycin, oxytetracycline, etc.).

[0096] In one embodiment, the signal transduction inhibitor fungicide may be selected from: aryloxyquinolines (e.g., quinoxyfen); quinazolinones (e.g., proquinazide); phenylpyrroles (e.g., fenpiclonil, fludioxonil); dicarbimides (e.g., chlozolinate, dimethacholine, iprodione, procymidone, and vinclozolin).

[0097] In one embodiment, the fungicide may be selected from: lipid synthesis and membrane integrity disruptors (e.g., phosphoro-thiolates (e.g., edifenphos, iprobenfos, pyrazolophos); dithiolenes (e.g., isoprothiolene); aromatic hydrocarbons (e.g., biphenyl, chloroneb, dicloran, quintozene (PCNB), tecnazene (TCNB), tolclofos-methyl, etc.); 1,2,4-thiadiazoles (e.g., etridiazole); carbamates (e.g., iodocarb, propamocarb, prothiocarb, etc.)).

[0098] Thus, in one embodiment, the sterol biosynthesis inhibitor may be selected from the following: triazoles (e.g., azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole), piperazines (e.g., triforine); pyridines (e.g., For example, pyrifenox, pyrisoxazole; pyrimidines (e.g., fenarimol, nuarimol; imidazoles (e.g., imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole); morpholines (e.g., aldimorph, dodemoflu, fenpropimorph, tridemorph, etc.); piperidines (e.g., fenpropidin, piperalin); spiroketal-amines (e.g., spiroxamine amine); hydroxyanilides (e.g., fenhexamid); amino-pyrazolinones (e.g., fenpyrazamine); thiocarbamates (e.g., pyributicarb); allylamines (e.g., naftifine, terbinafine) and mixtures thereof.

[0099] In one embodiment, the cell wall biosynthesis inhibitor fungicide may be selected from: peptidyl pyrimidine nucleoside fungicides (e.g., polyoxins), cinnamic amides (e.g., dimethomorph, flumorph, pyrimorph); valinamide carbamates (e.g., benthiavalicarb, iprovalicarb, valifenalate); mandelamides (e.g., mandipropamide) and mixtures thereof.

[0100] In one embodiment, the melanin synthesis inhibitor fungicide may be selected from the following: isobenzofuranones (e.g., fthalide); pyrroloquinolines (e.g., pyroquilon); triazolobenzo-thiazoles (e.g., tricyclazole); cyclopropane-carboxamides (e.g., carpropamid); carboxamides (e.g., diclocymet); propionamides (e.g., fenoxanil); trifluoroethyl carbamates (e.g., tolprocarb); and mixtures thereof.

[0101] In one embodiment, the host plant defense inducer fungicide may be selected from the following: benzo-thiadiazoles (e.g., acibenzolar-S-methyl); benzisothiazos (e.g., probenazole); thiadiazole-carboxamides (e.g., thiadinil, isotianil); polysaccharides (e.g., laminaran); and mixtures thereof.

[0102] In one embodiment, the second or third fungicide is an additional fungicide with an unknown mechanism of action and may be selected from: cyanoacetamide-oximes (e.g., cymoxanil); ethylphosphonates (e.g., fosetyl-Al, phosphorous acid and salts); phthalamic acids (e.g., tecloftalam); benzotriazines (e.g., triazoxide); benzenesulfonamides (e.g., flusulfamide); pyridazinones (e.g., diclomedine); thiocarbamates (e.g., metasulfocarb); phenyl-acetamides (e.g., cyflufenamid). ;aryl phenyl ketones (e.g., metrafenone, pyriophenone);guanidines (e.g., dodine);cyano-methylene-thiazolidines (e.g., flutianil);pyrimidinone-hydrazones (e.g., ferimzone);piperidinyl-thiazole-isoxazolines (e.g., oxathiapiproline);4-quinolyl-acetates (e.g., tebufloquine);tetrazolyl oximes (e.g., picarbutrazox);glucopyranosyl antibiotics (e.g., validamycin);fungicides (e.g., mineral oil, organic oil, potassium bicarbonate) and mixtures thereof.

[0103] In a preferred embodiment, the second fungicide in the combination of the present invention may be selected from the following: an ergosterol biosynthesis inhibitor and a quinone exo (Qo) inhibitor.

[0104] In another preferred embodiment, the second and third fungicides in the combination of the present invention may be selected from the following: an ergosterol biosynthesis inhibitor and a quinone exo (Qo) inhibitor, respectively.

[0105] The ergosterol biosynthesis inhibitor may be selected from the group consisting of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox, pyrisoxazole, and triforine.

[0106] In another embodiment, the ergosterol biosynthesis inhibitor may be selected from: prothioconazole, tebuconazole, hexaconazole, cyproconazole, or epoxiconazole.

[0107] In one embodiment, the third fungicide can be a quinone external (Qo) inhibitor fungicide selected from: azoxystrobin, comoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyraclostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, and pyribencarb.

[0108] In one embodiment, the quinone external (Qo) inhibitor fungicide may be selected from: azoxystrobin, picoxystrobin, kresoxim-methyl, pyraclostrobin and trifloxystrobin.

[0109] In one embodiment, the present invention provides a combination comprising: (a) at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, and tetraniliprole; (b) at least one multi-site fungicide; and (c) At least one silica-based plant health promoting additive.

[0110] In one embodiment, the present invention provides a combination comprising: (a) at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, and tetraniliprole; (b) at least one multi-site fungicide; and (c) at least a silica-based plant health promoting additive; (d) at least a first systemic fungicide and a second systemic fungicide.

[0111] In one embodiment, the multi-site fungicide may be selected from the following: (i) a copper fungicide selected from basic copper chloride, copper sulfate, copper hydroxide, and tribasic copper sulfate (Bordeaux mixture); (ii) elemental sulfur; (iii) a dithiocarbamate fungicide selected from ambam, asomate, azithiram, carbamorph, kufuraneb, kuprovam, disulfiram, ferbam, metham, nerbam, tecoram, thiram, urvacid, ziram, dazomet, ethem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb; (iv) a phthalimide fungicide selected from folpet, captan and captafol; (v) chlorothalonil; (vi) a sulfamide fungicide selected from dichlofluanid and tolylfluanid; (vii) a guanidine fungicide selected from dodine, guazanthine and iminoctazine; (viii) anilazine, (ix) dithianon, (x) Any combination thereof.

[0112] In one embodiment, the first and second systemic germicides are preferably different from each other.

[0113] In one embodiment, when the multi-site contact fungicide is a combination of mancozeb and chlorothalonil, the suitable systemic fungicide is at least one systemic fungicide selected from a quinone external inhibitor, a quinone internal inhibitor, a demethylation inhibitor, or a succinate dehydrogenase inhibitor.

[0114] In a preferred embodiment, the first and second systemic germicides are selected from different classes of systemic germicides, for example: (i) when the first systemic fungicide is a demethylation inhibitor, the second systemic fungicide is selected from a quinone external inhibitor, a quinone internal inhibitor, and a succinate dehydrogenase inhibitor; or (ii) when the first systemic fungicide is a quinone external inhibitor, the second systemic fungicide is selected from a quinone internal inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor; or (iii) when the first systemic fungicide is an internal quinone inhibitor, the second systemic fungicide is selected from an external quinone inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor; or (iv) When the first systemic fungicide is a succinate dehydrogenase inhibitor, the second systemic fungicide is selected from a quinone external inhibitor, a quinone internal inhibitor, and a demethylation inhibitor.

[0115] In one embodiment, the present invention provides (a) at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide, and tetraniliprole; (b) at least one multi-site fungicide; and (c) at least a silica-based plant health promoting additive; (d) a first systemic fungicide selected from a quinone external inhibitor, a quinone internal inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor; (e) a second systemic fungicide selected from a quinone external inhibitor, a quinone internal inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor; providing a combination comprising Whereby, (a) when the first systemic fungicide is a demethylation inhibitor, the second systemic fungicide is selected from a quinone external inhibitor, a quinone internal inhibitor, and a succinate dehydrogenase inhibitor; or (b) when the first systemic fungicide is a quinone external inhibitor, the second systemic fungicide is selected from a quinone internal inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor; or (c) when the first systemic fungicide is a quinone internal inhibitor, the second systemic fungicide is selected from a quinone external inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor; or (d) when the first systemic fungicide is a succinate dehydrogenase inhibitor, the second systemic fungicide is selected from a quinone external inhibitor, a quinone internal inhibitor, and a demethylation inhibitor; or (e) when the multi-site contact fungicide is a combination of mancozeb and chlorothalonil, the systemic fungicide is at least one of a quinone external inhibitor, a quinone internal inhibitor, a succinate dehydrogenase inhibitor, and a demethylation inhibitor.

[0116] In a preferred embodiment, the preferred quinone external inhibitor is a strobilurin fungicide and the preferred demethylation inhibitor is a conazole fungicide. In this embodiment, the preferred dithiocarbamate is selected from the group consisting of thiram, ziram, mancozeb, maneb, metiram, propineb and zineb.

[0117] In one embodiment, the quinone external inhibitor may be selected from fenamidone, famoxadone, and a strobilurin fungicide selected from the group consisting of azoxystrobin, mandestrobin, comoxystrobin, enoxastrobin, flufenoxystrobin, pyraoxystrobin, dimoxystrobin, enestrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, triclopyricarb, phenaminestrobin, pyraclostrobin, and trifloxystrobin.

[0118] In one embodiment, the quinone internal inhibitor may be selected from cyazofamid and amisulbrom.

[0119] In one embodiment, the demethylation inhibitor is selected from the group consisting of triflumizole, triforine, pyridinitrile, pyrifenox, fenarimol, nuarimol, triarimol, climbazole, clotrimazole, imazalil, oxpoconazole, prochloraz, prochloraz-manganese, triflumizole, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluotoxin, and a conazole fungicide selected from the group consisting of rimazole, fluquinconazole, flusilazole, flutriafol, fluconazole, fluconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, pencoconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, perfurazoate and uniconazole-P.

[0120] In one embodiment, the succinate dehydrogenase inhibitor may be selected from the group consisting of benodanil, flutolanil, mepronil, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, and boscalid.

[0121] In one embodiment, the second insecticidal compound in the combination of the present invention may be selected from the following: acetylcholinesterase (AChE) inhibitors, GABA-gated chloride channel blockers, sodium channel modulators, nicotinic acetylcholine receptor (nAChR) competitive modulators, nicotinic acetylcholine receptor (nAChR) allosteric modulators, glutamate-gated chloride channel (GluCl) allosteric modulators, juvenile hormone analogs, chordotonal organ TRPV channel modulators, mite growth inhibitors, fungal disruptors of insect midgut membranes, inhibitors of mitochondrial ATP synthase, uncouplers of oxidative phosphorylation via disruption of the proton gradient, nicotinic acetylcholine receptor (nAChR) channel blockers, inhibitors of chitin biosynthesis, molting disruptors, ecdysone receptor agonists, octopamine receptor agonists, mitochondrial complex electron transport inhibitors, voltage-dependent sodium channel blockers, inhibitors of acetyl-CoA carboxylase, chordotonal organ modulators, multi-site multi-use insecticides, bioinsecticides and mixtures thereof.

[0122] In one embodiment, the combination of the present invention may further include other plant health promoting additives (e.g., fertilizers, micronutrients, biological additives, etc. that are known to improve plant growth and health).

[0123] In one embodiment of the combination of the present invention, the preferred multi-site fungicide is mancozeb, the preferred diamide insecticidal compound is chlorantraniliprole, and the plant health additive is stabilized orthosilicic acid.

[0124] In one embodiment of the combination of the present invention, the preferred diamide insecticidal compound is cyantraniliprole.

[0125] In one embodiment of the combination of the present invention, the suitable diamide insecticidal compound is flubendiamide.

[0126] The combination of the present invention may be formulated in the form of a composition.

[0127] In one embodiment, the present invention may provide a composition comprising: a. at least one diamide insecticide; b. at least a silica-based plant health promoting additive; c. At least one pesticidally acceptable excipient.

[0128] In one embodiment, the present invention may provide a composition comprising: d. at least one diamide insecticide; e. at least one multi-site fungicide; f. at least a silica-based plant health promoting additive; g. At least one pesticidally acceptable excipient.

[0129] In a preferred embodiment, the present invention may provide a composition comprising: (a) at least one diamide pesticidal compound; (b) at least one dithiocarbamate fungicide; and (c) stabilized orthosilicic acid; (d) at least one pesticidally acceptable excipient.

[0130] In one embodiment, the present invention may provide a composition comprising: (a) at least one diamide pesticidal compound; (b) at least one dithiocarbamate fungicide; and (c) stabilized orthosilicic acid; (d) at least one fungicide or insecticide other than a diamide insecticide or a dithiocarbamate fungicide; (e) at least one pesticidally acceptable excipient.

[0131] In one embodiment, the present invention may provide a composition comprising: (a) at least one diamide pesticidal compound; (b) at least one dithiocarbamate fungicide; and (c) stabilized orthosilicic acid; (d) at least one other health-promoting additive selected from fertilizers, micronutrients, mycorrhizas, and biological additives that enhance plant growth; (e) at least one pesticidally acceptable excipient.

[0132] The application amount of the composition according to the invention depends on various factors, such as the treatment target (e.g. plants, soil or seeds); the treatment type (e.g. spraying, dusting or seed dressing); the purpose of the treatment (e.g. preventive or curative disease control); in the case of disease control, the type of fungus to be controlled or the application time. The application amount of the combination of the invention can be easily estimated by an agronomist in the field.

[0133] Thus, in one embodiment, the invention may provide a composition comprising: (a) at least one diamide insecticide selected from broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide flubendiamide, and tetraniliprole; (b) stabilized orthosilicic acid; (c) At least one dithiocarbamate fungicide.

[0134] In one embodiment, the total amount of the diamide insecticidal compounds in the composition can typically be in the range of 0.1-99% by weight (preferably 0.2-90% by weight). The total amount of the dithiocarbamate fungicides in the composition can be in the range of 0.1-99% by weight. The total amount of the silicic acid-based plant health promoting additives in the composition can be in the range of 0.1-99% by weight. The total amount of the second fungicide / insecticide / plant growth additives in the composition can be in the range of 0.1-99% by weight.

[0135] In one embodiment, the components of the combination of the present invention may be mixed with the dithiocarbamate fungicide, the anthranilamide insecticidal compound, and the silicic acid based plant health additive, respectively, in a ratio of (1-80):(1-80):(1-80).

[0136] In one embodiment, the components of the composition of the present invention may be tank mixed and sprayed onto the infested locus, or alternatively, may be mixed with a surfactant and then sprayed.

[0137] In one embodiment, the components of the composition of the present invention may be used for foliar application, terrestrial application or application to plant propagation material.

[0138] In one embodiment, the compositions of the present invention are typically produced by mixing the actives in the composition with an inert carrier, adding surfactants and other adjuvants and solids as necessary, and formulating into a solid or liquid formulation (including, but not limited to, wettable powders, granules, dusts, soluble (liquid) concentrates, suspension concentrates, oil-in-water emulsions, water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, ZC formulations, oil dispersions, or other types of known formulations). The compositions may be used to treat plant propagation material (e.g., seeds).

[0139] Examples of solid carriers used in formulation include fine powders or granules, such as minerals (e.g., china clay, attapulgite clay, bentonite, montmorillonite, acid clay, pyrophyllite, talc, diatomaceous earth, and calcite); natural organic materials (e.g., corn cob flour and walnut shell flour); synthetic organic materials (e.g., urea); salts (e.g., calcium carbonate and ammonium sulfate); synthetic inorganic materials (e.g., synthetic hydrous silicon oxide); liquid carriers, such as aromatic hydrocarbons (e.g., xylene, alkylbenzenes, and methylnaphthalene); alcohols (e.g., 2-propanol, ethylene glycol, propylene glycol, and ethylene glycol monoethyl ether); ketones (e.g., acetone, cyclohexanone, and isophorone); vegetable oils (e.g., soybean oil and cottonseed oil); petroleum aliphatic hydrocarbons, esters, dimethyl sulfoxide, acetonitrile, and water.

[0140] Examples of surfactants include anionic surfactants (e.g., alkyl sulfate ester salts, alkylaryl sulfonate salts, dialkyl sulfosuccinate salts, polyoxyethylene alkylaryl phosphate ether ester salts, lignosulfonate salts, and naphthalenesulfonic acid formaldehyde polycondensates); and nonionic surfactants (e.g., polyoxyethylene alkylaryl ethers, polyoxyethylene alkyl polyoxypropylene block copolymers, and sorbitan fatty acid esters) and cationic surfactants (e.g., alkyltrimethylammonium salts).

[0141] Examples of other dosage form adjuvants include: water-soluble polymers (e.g., polyvinyl alcohol and polyvinylpyrrolidone), polysaccharides (e.g., gum arabic, alginic acid and its salts, CMC (carboxymethyl-cellulose), xanthan gum), inorganic materials (e.g., magnesium aluminum silicate and alumina sol, preservatives, colorants) and stabilizers (e.g., PAP (isopropyl acid phosphate) and BHT).

[0142] The compositions according to the invention are effective against the following plant diseases: Rice diseases: Blast (Magnaporthe grisea), Helminthosporium leaf spot (Helminthosporium), Sheath blight (Rhizoctonia solani), and Gibberella fujikuroi. Wheat diseases: Powdery mildew (Erysiphe graminis), Fusarium head blight (Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. recondita), pink snow mold (Micronectriella nivale), snow mold sclerotinia (Typhula sp.), bare smut (Ustilago tritici), cattle smut (Tilletia caries), eyespot (Pseudocercosporella herpotrichoides), leaf blight (Mycosphaerella graminicola), leaf spot (Stagonospora nodorum), septoria, and yellow spot (Pyrenophora tritici-repentis).

[0143] Barley diseases: Powdery mildew (Erysiphe graminis), Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale, Rust (Puccinia striiformis, P. graminis, P. hordei), Striped smut (Ustilago nuda), Scorch (Rhynchosporium secalis), Net blotch (Pyrenophora teres), Leaf spot (Cochliobolus sativus), Striped leaf blight (Pyrenophora graminea), and Rhizoctonia damping-off (Rhizoctonia solani). Maize diseases: ear smut (Ustilago maydis), brown spot (Cochliobolus heterostrophus), leopard spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), grey spot (Cercospora zeae-maydis), white spot (Phaeosphaeria mydis and / or Pantoea ananatis) and Rhizoctonia damping-off (Rhizoctonia solani).

[0144] Citrus diseases: black spot (Diaporthe citri), fruit scab (Elsinoe fawcetti), blue mold (Penicillium digitatum, P. italicum), and red rot (Phytophthora parasitica, Phytophthora citrophthora).

[0145] Apple diseases: Blossom rot (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), Alternaria leaf spot (Alternaria alternata apple pathotype), spine disease (Venturia inaequalis), powdery mildew, bitter rot (Colletotrichum acutatum), head rot (Phytophtora cactorum), spot (Diplocarpon mali), and ring rot (Botryosphaeria berengeriana).

[0146] Pear diseases: fruit scab (Venturia nashicola, V.pirina), powdery mildew, black spot (Alternaria alternata Japanese pear pathotype), rust (Gymnosporangium haraeanum), and late blight (phytophthora fruit rot) (Phytophtora cactorum).

[0147] Peach diseases: Red rot (Monilinia fructicola), powdery mildew, fruit scab (Cladosporium carpophilum), and Phomopsis rot (Phomopsis sp.).

[0148] Grape diseases: Anthracnose (Elsinoe ampelina), late rot (Glomerella cingulata), powdery mildew (Uncinula necator), rust (Phakopsora ampelopsidis), black spot (Guignardia bidwellii), botrytis, and downy mildew (Plasmopara viticola).

[0149] Diseases of persimmon: anthracnose (Gloeosporium kaki), and spot disease (Cercospora kaki, Mycosphaerella nawae).

[0150] Diseases of gourd: Anthracnose (Colletotrichum lagenarium), powdery mildew (Sphaerotheca fuliginea), vine wilt (Mycosphaerella melonis), wilt (Fusarium oxysporum), downy mildew (Pseudoperonospora cubensis), late blight (phytophthora rot) (Phytophthora sp.), and damping off (Pythium sp.).

[0151] Tomato diseases: summer blight (Alternaria solani), spotted blight (Cladosporium fulvum), and leaf spot (Phytophthora infestans).

[0152] Eggplant diseases: brown spot disease (Phomopsis vexans), powdery mildew (Erysiphe cichoracearum), Cruciferous vegetable diseases: Alternaria leaf spot disease (Alternaria japonica), white spot disease (Cercosporella brassicae), clubroot disease (Plasmodiophora brassicae), and downy mildew (Peronospora parasitica).

[0153] Onion diseases: Rust (Puccinia allii) and downy mildew (Peronospora destructor).

[0154] Soybean diseases: Purple spot (Cercospora kikuchii), sphaceloma scad (Elsinoe glycines), black spot (Diaporthe phaseolorum var. sojae), Septoria brown spot (Septoria glycines), leaf spot (Cercospora sojina), rust (Phakopsora pachyrhizi), yellow rust, leaf drop (Phytophthora sojae), and Rhizoctonia damping off (Rhizoctonia solani).

[0155] Diseases of beans: anthracnose (Colletotrichum lindemthianum). Diseases of peanuts: leaf spot (Cercospora personata), brown spot (Cercospora arachidicola) and southern blight (Sclerotium rolfsii).

[0156] Pea diseases: Powdery mildew (Erysiphe pisi), and root rot (Fusarium solani f.sp.pisi).

[0157] Potato diseases: summer blight (Alternaria solani), late blight (Phytophthora infestans), leaf blight (Phytophthora erythroseptica), and powdery scab (Spongospora subterranean f.sp. subterranea).

[0158] Strawberry diseases: Powdery mildew (Sphaerotheca humuli) and anthracnose (Glomerella cingulata).

[0159] Tea leaf diseases: Net blight (Exobasidium reticulatum), white spot (Elsinoe leucospila), grayblight (Pestalotiopsis sp.), and anthracnose (Colletotrichum theae-sinensis).

[0160] Tobacco diseases: Brown spot (Alternaria longipes), Powdery mildew (Erysiphe cichoracearum), Anthracnose (Colletotrichum tabacum), Downy mildew (Peronospora tabacina), and Tobacco late blight (Phytophthora nicotianae).

[0161] Canola diseases: Sclerotinia sclerotiorum and Rhizoctonia solani. Cotton diseases: Rhizoctonia solani.

[0162] Sugar beet diseases: Cercospora leaf spot (Cercospora beticola), leaf blight (Thanatephorus cucumeris), root rot (Thanatephorus cucumeris), and Aphanomyces root rot (Aphanomyces cochlioides).

[0163] Rose diseases: black spot (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa), and downy mildew (Peronospora sparsa).Chrysanthemum and Asteraceae diseases: downy mildew (Bremia lactucae), leaf blight (Septoria chrysanthemi-indici), and white rust (Puccinia horiana).

[0164] A diverse group of diseases: diseases caused by Pythium spp. (Pythium aphanidermatum, Pythium debarianum, Pythium graminicola, Pythium irregulare, Pythium ultimum), grey mold (Botrytis cinerea), and stem rot (Sclerotinia sclerotiorum).

[0165] Radish diseases: Alternaria leaf spot (Alternaria brassicicola).

[0166] Turfgrass diseases: Dollar spot (Sclerotinia homeocarpa), and brown patch and large patch (Rhizoctonia solani).

[0167] Banana diseases: Black Sigatoka (Mycosphaerella fijiensis), Yellow Sigatoka (Mycosphaerella musicola).

[0168] Sunflower diseases: Downy mildew (Plasmopara halstedii). Seed diseases or diseases in the early growth stages of various plants caused by: Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., Rhizoctonia spp. and Diplodia spp.

[0169] A variety of plant viral infections transmitted by Polymixa spp. or Olpidium spp.

[0170] In one embodiment, the insect pests controlled by the combination of the present invention may belong to the classes Insecta, Arachnida and Nematoda. Exemplary pests include: Lepidoptera pests (e.g. Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp., Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Crocidolomia spp., Cryptophlebia leucotreta, Crysodeixis includens, Cydia spp., Diatraea spp., Diparopsis castanea, Earias spp., Elasmopalpus spp., Ephestia spp., Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Grapholita spp., Hedya nubiferana, Heliothis spp., Hellula undalis, Hyphantria cunea, Keiferia lycopersicella, Leucoptera scitella, Lithocollethis spp., Lobesia botrana, Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Operophtera spp., Ostrinia nubilalis, Pammene spp., Pandemis spp., Panolis flammea, Pectinophora gossypiella, Phthorimaea operculella, Pieris rapae, Pieris spp., Plutella xylostella, Prays spp., Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodoptera spp., Synanthedon spp., Thaumetopoea spp., Tortrix spp., Trichoplusia ni and Yponomeuta spp.); pests from the order Coleoptera (e.g. Agriotes spp., Anthonomus spp., Atomaria linearis, Ceutorhynchus spp., Chaetocnema tibialis, Cosmopolites spp., Curculio spp., Dermestes spp., Diabrotica spp., Epilachna spp., Eremnus spp., Gonocephalum spp., Heteronychus spp., Leptinotarsa ​​decemlineata, Lissorhoptrus spp., Melolontha spp., Orycaephilus spp., Otiorhynchus spp., Phlyctinus spp., Phyllotreta spp., Popillia spp., Protostrophus spp., Psylliodes spp., Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Tenebrio spp., Tribolium spp. and Trogoderma spp.); pests from the order Orthoptera (e.g. Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Periplaneta spp. and Schistocercas pp.); pests from the order Isoptera (e.g. Reticulitermes spp.); pests from the order Psocoptera (e.g. Liposcelis spp.); pests from the order Phthiraptera (e.g. Haematopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp. and Phylloxera spp.); pests from the order Thripidae (e.g. Damalinea spp. and Trichodectes spp.); pests from the order Thripidae (e.g. Frankliniella spp., Hercinothrips spp., Taeniothrips spp., Thrips palmi, Thrips tabaci and Scirtothrips aurantii); pests from the suborder Heteroptera (e.g. Dichelops melacanthus, Distantiella theobroma, Dysdercus spp., Euchistus spp., Eurygaster spp., Leptocorisa spp., Nezara spp., Piesma spp., Rhodnius spp., Sahlbergella singularis, Scotinophara spp. and Triatoma spp.); insect pests from the order Ceratoptera (e.g. Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella spp., Aphididae, Aphis spp., Aspidiotus spp., Bemisia tabaci, Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus hesperidum, Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Laodelphax spp., Lecanium corni, Lepidosaphes spp., Macrosiphus spp., Myzus spp., Nephotettix spp., Nilaparvata spp., Paratoria spp., Pemphigus spp., Planococcus spp., Pseudaulacaspis spp., Pseudococcus spp., Psylla spp.Pulvinaria aethiopica Quadraspidiotus spp. Rhopalosiphum spp. Saissetia spp. Scaphoideus spp. Schizaphis spp. Sitobion spp citri);fruits of fermentation (including Acromyrmex, Athalia rosae, Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis, Neodiprion spp., Solenopsis spp., and Vespa spp.); spp.. Chrysomyia spp. Culex spp. Cuterebra spp. Dacus spp. Delia spp. Drosophila melanogaster Liriomyza spp. Melanagromyza spp. Orseolia spp. Oscinella frit Pegomyia hyoscyami, Phorbia spp., Rhagoletis pomonella, Sciara spp.); spp.、Brevipalpus spp.、Bryobia praetiosa、Calipitrimerus spp.、Chorioptes spp.Dermanyssus gallinae.Eotetranychus carpini.Eriophyes spp.Hyalomma spp.Olygonychus pratensis.Ornithodoros spp., Panonychus spp., Phyllocoptruta spp.(e.g. Phyllocoptruta oleivora), Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus spp. and Tetranychus spp.); as well as from the nematodes Meloidogyne spp. species (e.g. Meloidogyne incoginita and Meloidogyne javanica), Heterodera spp. (e.g. Heterodera glycines, Heterodera schachtii, Heterodora avenae and Heterodora trifolii), Globodera spp. (e.g. Globodera rostochiensis), Radopholus spp. (e.g. Radopholus similes), Rotylenchulus spp., Pratylenchus (e.g. Pratylenchus neglectans and Pratylenchus penetrans), Aphelenchoides spp., Helicotylenchus spp., Hoplolaimus spp., Paratrichodorus spp., Longidorus spp., Nacobbus spp., Subanguina spp.Belonlaimus spp., Criconemella spp., Criconemoides spp., Ditylenchus spp., Dolichodorus spp., Hemicriconemoides spp., Hemicycliophora spp., Hirschmaniella spp., Hypsoperine spp., Macroposthonia spp., Melinius spp., Punctodera spp., Quinisulcius spp., Scutellonema spp., Xiphinema spp., and Tylenchorhynchus spp.

[0171] The composition of the present invention can be used in agricultural land (e.g., fields, paddy fields, lawns and orchards) or non-agricultural land. The present invention can be used to control plant diseases in agricultural land without causing any phytotoxicity to the plants.

[0172] Examples of crops for which the compositions of the present invention can be used include, but are not limited to, corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, beets, rapeseed, sunflowers, sugarcane, tobacco, etc.; vegetables: solanaceae (e.g., eggplant, tomato, pepper, chilli, potato), cucurbits (e.g., cucumber, pumpkin, zucchini, watermelon, melon, squash), cruciferous plants. Plants (e.g., radish, turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, mustard, broccoli, cauliflower), Asteraceae plants (e.g., burdock, chrysanthemum, artichoke, lettuce), lily family vegetables (e.g., leeks, onions, garlic, and asparagus), Apiaceae plants (e.g., carrots, parsley, celery, parsley), Chenopodiaceae plants (e.g., spinach, Swiss chard), Lamiaceae plants (e.g., Perilla, mint, basil, etc.), strawberries, sweet potatoes, Chinese yams, taro, flowers, foliage, turfgrass, fruits: pome fruits (e.g. apples, pears, quince), stone fruits (e.g. peaches, plums, nectarines, plums, cherries, apricots, prunes), citrus fruits (e.g. oranges, lemons, limes, grapefruits), nuts (e.g. chestnuts, walnuts, hazelnuts, almonds, pistachios, cashews, macadamia nuts), berries non-fruit trees, such as berries (e.g., blueberries, cranberries, blackberries, raspberries), grapes, persimmons, olives, plums, bananas, coffee, dates, coconuts, etc.; tea, mulberries, flowering plants, trees (e.g., ash, birch, dogwood, eucalyptus, ginkgo, lilac, maple, oak, poplar, sedge, mallow, sycamore, zelkova, mouse, fir, hemlock, juniper, pine, spruce, and yew).

[0173] In one embodiment, the components of the combination of the present invention may be mixed in a ratio of (1-80):(1-80):(1-80):(1:80).

[0174] In one aspect, the present invention may provide a method for controlling fungi and / or killing pests in a habitat and promoting plant health, the method comprising applying a combination comprising: (a) at least one diamide insecticide; (b) at least one dithiocarbamate fungicide; and (c) Silica-based plant health promoting additives.

[0175] In one embodiment, the diamide insecticide, the dithiocarbamate fungicide and the silicic acid-based plant health promoting additive may be selected according to any of the preferred embodiments of the combination described above.

[0176] In an embodiment, the combination of the present invention may be used to promote plant health. The method comprises applying the following combination: (a) at least one diamide insecticide; (b) at least one dithiocarbamate fungicide; and (c) Silica-based plant health promoting additives.

[0177] In one embodiment, the diamide insecticide, the dithiocarbamate fungicide and the silicic acid-based plant health promoting additive may be selected according to any of the preferred embodiments of the combination described above.

[0178] The combinations of the present invention may be sold as premixed compositions or as kits of parts such that the individual actives can be mixed prior to spraying. Alternatively, the kits of parts may contain premixed dithiocarbamate fungicides and second and / or third fungicides, with the diamide insecticide being mixed with separately packaged adjuvants and silicic acid-based plant health additives, allowing the three components to be tank mixed prior to spraying.

[0179] The compositions of the present invention may be applied simultaneously as tank mixtures or formulations, or may be applied sequentially.This application may be applied to soil before plant emergence, before planting, or after planting.This application may be applied as foliar spray at different times during crop development, once or twice, early or late after emergence.

[0180] Brief description of the preferred embodiment: In exemplary embodiments, some preferred embodiments according to the present invention include the following preferred combinations:

[0181] In one embodiment, the present invention also provides a composition comprising a combination as exemplified in the table below and at least one pesticidally acceptable excipient.

[0182] [Table 1-1]

[0183] [Table 1-2]

[0184] [Table 1-3]

[0185] [Table 1-4]

[0186]

Table 1-5

[0187]

Table 1-6

[0188]

Table 1-7

[0189]

Table 1-8

[0190]

Table 1-9

[0191]

Table 1-10

[0192]

Table 1-11

[0193]

Table 1-12

[0194]

Table 1-13

[0195]

Table 1-14

[0196] [Table 1-15]

[0197] These combinations merely represent exemplary embodiments of the present invention and should not be construed as limiting the scope of the invention.

[0198] The compositions according to the invention can be applied before or after the useful plants or their propagation material are infected with fungi.

[0199] As described, the addition of the silicic acid-based plant health additive to the combination of the dithiocarbamate fungicide and the diamide insecticide compound significantly improved disease control, improved yield, and produced synergistic effects. The lower the performance of the mixture in disease control, the higher the additional benefit of the silicic acid-based plant health additive when added to the composition of the present invention.

[0200] In one embodiment, the present invention provides a composition comprising chlorantraniliprole in an amount of about 45 g / ha, acetamiprid in an amount of about 40 g / ha, methoxyfenozide in an amount of 180 g / ha, and orthosilicic acid in an amount of about 250-750 g / ha.

[0201] Those skilled in the art will, upon reading the above description of the invention, be able to make and use what is believed to be the best mode thereof, but will understand and appreciate that there are variations, combinations and equivalents of the specific embodiments, methods, and examples herein. Thus, the present invention should not be limited by the above embodiments, methods, and examples, but rather by all embodiments and methods within the scope and spirit of the present invention. EXAMPLES

[0202] Trials were conducted with different doses of a combination of chlorantraniliprole and orthosilicic acid to test their effectiveness in controlling fruit borers. The results are summarized in the table below.

[0203] [Table 2]

[0204] Thus, in one embodiment, the present invention provides a combination of chlorantraniliprole and orthosilicic acid.

[0205] In another embodiment, the combination provided by the present invention comprises chlorantraniliprole in an amount of 150 g / ha and orthosilicic acid in an amount of about 750 g / ha.

[0206] In one embodiment, a composition provided by the present invention comprises a combination as described in any of the above embodiments and at least one pesticidally acceptable excipient.

[0207] In one embodiment the invention provides a method for controlling fruit borers comprising applying to a locus a combination or composition as described in any of the above embodiments.

[0208] Conclusion: Chlorantraniliprole plus OSA applied at a rate of 150 + 750 gm / h showed synergy in the control of fruit borers compared to chlorantraniliprole applied alone, showing 83.11% control. EXAMPLES

[0209] The combination of chlorantraniliprole + mancozeb + orthosilicic acid was tested for its effectiveness in controlling late blight.

[0210] [Table 3]

[0211] Conclusion: When chlorantraniliprole + mancozeb + orthosilicic acid was applied at a dose of 150 + 2000 + 500, the control of late blight was increased compared to chlorantraniliprole and mancozeb applied alone. Therefore, it was concluded that the addition of orthosilicic acid acts as a synergist and increases the effectiveness of the combination of chlorantraniliprole + mancozeb.

[0212] Thus, in one embodiment, the invention provides a combination comprising chlorantraniliprole, mancozeb and orthosilicic acid.

[0213] Thus, in one embodiment, the combination provided by the present invention comprises chlorantraniliprole in an amount of 150 g-mL / ha, mancozeb in an amount of about 1500 g / ha, and orthosilicic acid in an amount of about 500 g / ha.

[0214] In another embodiment, the combination provided by the present invention comprises chlorantraniliprole in an amount of 150 g-mL / ha, mancozeb in an amount of about 2000 g / ha, and orthosilicic acid in an amount of about 500 g / ha.

[0215] In one embodiment, the combination provided by the present invention comprises chlorantraniliprole in an amount of 150 g-mL / ha, mancozeb in an amount of about 1500 g / ha, and orthosilicic acid in an amount of about 750 g / ha.

[0216] In another embodiment, the combination provided by the present invention comprises chlorantraniliprole in an amount of 150 g-mL / ha, mancozeb in an amount of about 2000 g / ha, and orthosilicic acid in an amount of about 750 g / ha.

[0217] In one embodiment, the present invention provides a composition comprising a combination as described in any of the above embodiments, and at least one pesticidally acceptable excipient.

[0218] In one embodiment, the present invention provides a method for controlling late blight, the method comprising applying to a locus a combination or composition as described in any of the above embodiments.

[0219] More specifically, the present invention is described by the above examples. However, it should be understood that the scope of the present invention is not limited in any manner by these examples. Those skilled in the art will recognize that the present invention includes the above examples and can be modified and changed within the technical scope of the present invention.

Claims

1. a. at least one diamide insecticide; b. orthosilicic acid as a plant health promoting additive; wherein the diamide insecticide is at least one selected from broflanilide, cyantraniliprole, cyclaniliprole, cyhalodiamide, and tetraniliprole.

2. 10. The mixture of claim 1, optionally further comprising mancozeb, folpet, chlorothalonil, tribasic copper sulfate, cyproconazole, difenoconazole, epoxiconazole, hexaconazole, tebuconazole, tetraconazole, prothioconazole, azoxystrobin, or combinations thereof.

3. A mixture according to claim 1 ; at least one pesticidally acceptable excipient; A composition comprising:

4. A mixture according to claim 2; at least one pesticidally acceptable excipient; A composition comprising:

5. The composition of claim 3 or 4, further comprising an adjuvant, a carrier, a diluent, an emulsifier, a filler, an antifoaming agent, a thickener, a cryoprotectant, a freezing agent.

6. The composition of claim 3 or 4, wherein the composition is in a solid or liquid dosage form.

7. 10. A method for controlling fungal diseases comprising applying to a locus a mixture according to claim 1 or 2 or a composition according to claim 3 or 4.

8. 10. A method for resistance management in crops, comprising the application to said crops of a mixture as described in claim 1 or 2 or a composition as described in claim 3 or 4.

9. 10. A method for preventing resistance in fungi, comprising applying a mixture according to claim 1 or 2 or a composition according to claim 3 or 4 to the locus of a plant.

10. 10. A method for controlling insect pests comprising applying to a locus a mixture according to claim 1 or 2 or a composition according to claim 3 or 4.

11. A kit comprising a mixture according to claim 1 or 2 or a composition according to claim 3 or 4.

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