A beauty method to brighten the entire face using microneedling

Abstract

To provide novel beauty methods that improve blood circulation throughout the face and brighten the color tone of the entire face.SOLUTION: Provided is a beauty method that brightens the color tone of the entire face by attaching a microneedle sheet with multiple microneedles to a part of the face.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a novel cosmetic method for improving blood circulation throughout the face and brightening the skin tone. [Background technology]

[0002] In terms of beauty, not only daily care such as lotions and cosmetics suited to the skin condition of the subject and massage, but also the adoption of iontophoresis and lasers, beauty technology continues to evolve day by day. In recent years, "microneedle technology" has been attracting attention in the beauty industry. In the beauty industry, microneedle technology is a technology that makes it possible to provide deeper moisture to the skin by solidifying biodegradable ingredients such as hyaluronic acid into needle-like shapes and attaching them to the skin, allowing the ingredients to dissolve. It is a skin care item developed in pursuit of penetrating hyaluronic acid into the skin, rather than simply applying it to the surface of the skin. By sticking it on the skin for a few hours, for example overnight, the beauty effects obtained by microneedles are recognized to not only increase moisture, but also to increase skin firmness and elasticity, and improve dark circles and dullness under the eyes.

[0003] Due to aging, stress, and the like, the face tends to become congested and dark in color. Brightening or maintaining a bright facial tone is an important factor in maintaining a youthful appearance. For this reason, daily efforts are required to improve blood circulation in the skin and activate metabolism. Therefore, a simple means for improving blood circulation in the face and brightening the overall facial tone is desired in the beauty industry. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent No. 3553956 Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide a novel cosmetic method for improving blood circulation in the entire face and brightening the overall facial tone. [Means for solving the problem]

[0006] The inventor of the present invention discovered that continuous use of microneedles under the eyes not only improves the tone of dark circles under the eyes, but also surprisingly improves blood circulation throughout the face, brightening the overall tone of the face, and thus completed the present invention. It was not known that microneedles have such an effect. Therefore, the present application provides the following invention.

[0007] (1) A beauty method that brightens the overall facial tone by applying a microneedle sheet containing multiple microneedles to part of the face. (2) A beauty method similar to (1), in which a microneedle sheet is applied to the areas under the eyes where dark circles appear. (3) The cosmetic method according to (1) or (2), wherein the microneedles are made of hyaluronic acid. (4) Any of the cosmetic methods (1) to (3), wherein the height of the microneedles is 50 to 200 μm. (5) The area of ​​the microneedle sheet is 500 to 3,000 mm 2 A beauty method which is any one of (1) to (4). (6) A microneedle sheet formulation that contains multiple microneedles made of hyaluronic acid and is attached to parts of the face to improve blood circulation. (7) A microneedle sheet formulation of (6) that brightens the overall facial tone. (8) A microneedle sheet formulation of (6) or (7) to be applied to the area under the eyes. (9) The microneedle sheet preparation according to any one of (6) to (8), wherein the height of the microneedles is 50 to 200 μm. (10) Area is 500 to 3,000 mm 2 The microneedle sheet preparation according to any one of (6) to (9). Effect of the Invention

[0008] By applying the microneedle sheet of the present invention to a part of the face and using it continuously for a predetermined period of time, it is possible to improve blood circulation not only in the part where the sheet is applied but in the entire face, and brighten the color of the entire face. [Brief description of the drawings]

[0009] [Figure 1] This shows that application of a microneedle sheet improves blood circulation not only at the application site but also in the surrounding area. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The microneedle sheet referred to in the present invention refers to a microneedle array in which a plurality of fine microneedles are formed on the surface of a substrate.

[0011] The cosmetic method of the present invention is carried out by applying the microneedle sheet to a part of the face, preferably to the area where dark circles under the eyes are formed, for several hours, for example, overnight, preferably 1 to 12 hours, for example, 3 to 10 hours, for example, 1 to 4 times a week, preferably twice a week, for example, for 1 to 6 months, preferably for 2 months. This continuous application method may be carried out continuously, or may be carried out intermittently, for example, at intervals of several months, several times a year.

[0012] According to the cosmetic method using the microneedle sheet of the present invention, by applying the sheet to a part of the face and using it continuously, blood circulation is improved not only in the part where the sheet is applied, but also over a wide area of ​​the face, and as a result, the facial tone that has become dull and dark due to congestion can be brightened. The degree of facial tone can be determined, for example, by tracking changes in the L value and a value using a spectrophotometric colorimetric system. The L value is an index of skin transparency, and an increase in this value means that the transparency of the skin has been improved, and thus the skin appears brighter. The a value is an index of skin redness, and a decrease in this value means that the redness has been improved, and thus the skin becomes whiter. Facial blood circulation can be determined by laser Doppler testing, laser imaging speckle tracking, and the like.

[0013] The material forming the microneedle used in the present invention may be any material that has a certain degree of hardness so as to penetrate the skin and provide stimulation, and the material itself is not particularly limited. However, since it is to be attached to the skin for a long time, it must be a biocompatible material, and is preferably formed from a material that can dissolve or swell in the body. Examples of such materials include polysaccharides such as hyaluronic acid, chitosan, maltose, alginate, amylose, and agarose, celluloses such as carboxymethylcellulose and hydroxypropylcellulose, and starch, and may be formed from each material alone or from a mixture of two or more materials appropriately blended. A particularly preferred material is hyaluronic acid. Hyaluronic acid is usually used in the form of a salt, and examples of the salt include metal salts such as sodium salt and potassium salt. Hyaluronic acid can be used from low molecular weight ones with an average molecular weight of 10,000 or less, measured by HPLC, to high molecular weight ones with an average molecular weight of 800,000 or more, and low molecular weight ones and high molecular weight ones can be mixed appropriately. Alternatively, the material forming the microneedles may be formed from a resin that does not dissolve or swell in the body and does not affect the body, and examples of materials include, but are not limited to, polymethyl methacrylate, cellulose acetate, ethyl cellulose, polyethylene resin, polypropylene resin, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, vinyl chloride resin, vinylidene chloride resin, vinyl acetate-vinyl chloride copolymer, polyamide resin, polyester resin, ABS resin, SIS resin, SEBS resin, urethane resin, silicone resin, aluminum, etc.

[0014] As long as the substrate of the microneedle sheet can have a surface on which microneedles can be formed, its material may be the same as or different from that of the microneedles, and is not particularly limited, and examples thereof include films or sheets of polymethyl methacrylate, cellulose acetate, ethyl cellulose, polyethylene resin, polypropylene resin, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, vinyl chloride resin, vinylidene chloride resin, vinyl acetate-vinyl chloride copolymer, polyamide resin, polyester resin, ABS resin, SIS resin, SEBS resin, urethane resin, silicone resin, aluminum, etc. Also, it may be a film or sheet made of collagen and / or gelatin.

[0015] The microneedles may contain medicinal ingredients such as water-soluble drugs and cosmetic ingredients that have been conventionally used as transdermal absorption preparations, for example, whitening ingredients such as ascorbyl palmitate, kojic acid, rucinol, tranexamic acid, potassium 4-methoxysalicylate, pyrimidinylpyrazole compounds, liquorice extract, oil-based licorice extract, and vitamin A derivatives; anti-wrinkle ingredients such as retinol, retinoic acid, retinol acetate, and retinol palmitate; blood circulation promoting ingredients such as tocopherol acetate, capsaicin, and vanillylamide norylate; diet ingredients such as raspberry ketone, evening primrose extract, and seaweed extract; antibacterial ingredients such as isopropyl methylphenol, photosensitizer, and zinc oxide; and vitamins such as vitamin D2, vitamin D3, and vitamin K.

[0016] The shape of the microneedle is not particularly limited, but a cone shape, a truncated cone shape, a cone-shaped shape, or the like is preferable so that it can be easily inserted into the skin and does not cause pain when inserted. The cone-shaped shape is a so-called volcano shape, and the side of the truncated cone shape is curved inward.

[0017] The diameter of the base of the microneedle is preferably about 0.15 to 1.0 mm, and more preferably about 0.15 to 0.5 mm, since a thinner microneedle is more likely to break when inserted into the skin, and a thicker microneedle is more painful when inserted into the skin. The diameter of the tip of the microneedle is preferably about 0.01 to 0.2 mm, since a thinner microneedle (pointed microneedle) is more likely to break when inserted into the skin, and a thicker microneedle is more difficult to insert into the skin and painful.

[0018] The height of the microneedle is required to be high enough to penetrate the skin and stimulate it, but if it is too high, it may reach the skin basement membrane and may be easily broken when penetrated into the skin, so it is appropriate to be about 50 μm to 1000 μm, preferably about 100 to 500 μm. Also, if the microneedle and the pitch of the microneedle are short, it becomes difficult to penetrate into the skin, and if they are long, the number of microneedles per area decreases, and the effect of the present invention may not be achieved, so it is appropriate to be 0.3 to 1.0 mm.

[0019] In the present invention, the microneedle sheet is applied to a part of the face to improve blood circulation in the entire face and to brighten the face, so it is preferable that the area of ​​the microneedle sheet has a certain degree of size. Although not particularly limited, the area is preferably at least 200 mm2. 2 , preferably 500 to 3,000 mm 2 It is.

[0020] The method for producing the microneedle array of the present invention is not particularly limited, and any conventionally known method may be used, for example, the following production method. (1) A method in which an aqueous solution of a material mainly composed of a microneedle-forming material such as hyaluronic acid, to which medicinal ingredients or cosmetic ingredients may be added as necessary, is cast onto a mold punched in the shape of a microneedle, and the water is evaporated at room temperature or by heating to dry the material, and a substrate is then laminated thereon and the resulting material is then peeled off to transfer the microneedle onto the substrate.

[0021] (2) A method in which the aqueous solution is cast onto the surface of the mold so as to form a layer, and then the layer is dried at room temperature or by heating to evaporate the water, followed by peeling. With this method, a microneedle array can be obtained in which both the substrate and the microneedles are made of a material mainly composed of the microneedle-forming material, to which medicinal ingredients and cosmetic ingredients may be added as necessary.

[0022] (3) A method in which an aqueous solution of a material primarily made of microneedle-forming material, to which medicinal or cosmetic ingredients may be added as necessary, is injection molded onto a substrate into the shape of a microneedle, and then the water is evaporated and the material is dried at room temperature or by heating. EXAMPLES

[0023] Experiment 1 Thirty-one healthy women aged 30 to 55 with dark circles under their eyes were asked to apply the microneedle sheet twice a week during sleep for four weeks to the dark circles under both eyes (the so-called pigmented areas). The specifications of the microneedle sheet used are as follows: Material: Sodium hyaluronate (average molecular weight 50,000 to 100,000) Area approximately 975 mm 2 Needle height: 200μm Number of needles: 2000 Base diameter: 200μm Needle pitch: 540μm

[0024] After 4 weeks, the subjects' facial color was measured using a spectrophotometer (Konica Minolta: Model CM-600d). The results are shown in the table below. [Table 1]

[0025] In the table above, the L value represents the transparency of the skin, the a value represents the redness of the skin, and the b value represents the yellowness of the skin. The higher the L value, the better the results, while the lower the a and b values. As is clear from the table above, continued use of the microneedle sheet not only improved redness (a value) in the pigmented areas where the sheet was applied, but also improved redness (a value) on the cheeks where the sheet was not directly applied.

[0026] Experiment 2 Furthermore, the blood flow condition of the face of the subject was measured using a laser Doppler (model name: OMEGAFLO-N1, OMEGA WAVE Co., Ltd.). The results are shown in the table below. [Table 2]

[0027] As is clear from the above table, it can be seen that continuous use of the microneedle sheet significantly increases the blood flow volume and blood flow velocity at the pigmentation site where the sheet is applied. Therefore, it is believed that continuous use of the sheet improves congestion and improves color tone.

[0028] Interestingly, about 20% of the subjects showed a more significant improvement in the a-value (redness) in the area around the cheek where the sheet was applied than in the area where the sheet was applied. The results of one of these subjects are shown in the table below. [Table 3]

[0029] Therefore, we investigated whether blood circulation around the area where the microneedle sheet was applied was promoted in several subjects. In detail, a microneedle sheet was attached around the eye, and the blood flow condition in the surrounding area was determined by irradiating the living tissue with a laser to form speckles (spots) using a laser imaging speckle (PeriCam PSI: PERIMED, Sweden), and tracking the changes in the speckles due to the movement of blood flow. The results are shown in Figure 1. It was found that the blood flow condition was promoted not only in the area where the microneedle sheet was attached, but also in the surrounding area. Therefore, it can be seen that the use of microneedles improves facial dullness caused by congestion. [Industrial Applicability]

[0030] By using the microneedle sheet of the present invention, by simply applying it to a part of the face and using it continuously for a specified period of time, it is possible to improve blood circulation not only in the part where the sheet is applied but in the entire face, and brighten the overall facial tone.

Claims

1. A cosmetic method for improving redness or yellowness around the eyes or cheeks by applying a microneedle sheet containing multiple microneedles made of hyaluronic acid to the areas under the eyes where dark circles appear.

2. The cosmetic method according to claim 1, wherein the height of the microneedles is 50 to 200 μm.

3. The area of ​​the microneedle sheet is 500 to 3,000 mm 2 The cosmetic method according to claim 1 or 2,

4. A microneedle sheet preparation having a plurality of microneedles made of hyaluronic acid arranged thereon is applied to areas with dark circles under the eyes to improve redness or yellowness around the eyes or cheeks.

5. The microneedle sheet preparation according to claim 4, wherein the height of the microneedles is 50 to 200 μm.

6. Area is 500 to 3,000 mm 2 The microneedle sheet formulation according to claim 4 or 5,

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