Pouched product containing liquid flavoring composition

Abstract

An oral pouched product is disclosed, comprising a saliva-permeable pouch and a pouch composition, the pouch composition comprising a powdered composition, water, and a liquid flavoring composition, the liquid flavoring composition being added to the powdered composition after the water. Additional oral pouched products and methods of making the oral pouched products are disclosed.

Description

[Technical field]

[0001] The present invention relates to an oral pouched product according to claim 1, an oral pouched product comprising according to claim 69 and a method for producing an oral pouched product according to claim 71. [Background technology]

[0002] Delivery of nicotine through smoking has many well-known drawbacks, particularly health-related problems such as the inclusion of carcinogens. However, tobacco substitutes also have drawbacks, such as insufficient relief of cravings in users. Summary of the Invention [Problem to be solved by the invention]

[0003] It is an object of one embodiment of the present invention to provide a nicotine-containing pouch, for example as a tobacco substitute, which can solve the above problems. Pouched products for oral delivery, such as nicotine, have proven to be attractive, user-friendly and attractive vehicles for the delivery of certain types of substances, such as active ingredients, sugars or sweeteners, etc. However, a challenge associated with such vehicles is that the substance to be delivered must be released from the pouch, at least in part, as a result of salivation in the user's mouth. If such salivation is inhibited or reduced in any way, the intended delivery profile may be unintentionally altered. For example, when releasing nicotine, complete drying of the pouch contents may affect the contact area of ​​the oral cavity.

[0004] The above problems are addressed in several aspects of the present invention. [Means for solving the problem]

[0005] The present invention relates in a first aspect to an oral pouched product, said oral pouched product comprising: Saliva-permeable pouches and pouch compositions, Including, The pouch composition comprises: A powdered composition; Water, A liquid flavoring composition; wherein the liquid flavor composition is added to the powdered composition after the water.

[0006] The advantage of the present invention can be that a highly desirable flavor release can be obtained. By using the liquid flavor composition according to the present invention, the user experiences an initial noticeable flavor burst. The liquid flavor composition distributes over a wide surface of the provided mixture containing sugar alcohol and water, thereby promoting effective contact with saliva, which also advantageously promotes flavor release.

[0007] The invention, on the other hand, counteracts the drying of the mucosa in order to stimulate saliva secretion, especially in the initial phase of use of the pouch. The invention provides an initial burst of flavor, which also promotes saliva secretion, which affects the release, and at the same time makes it possible to obtain an impressive flavor profile that is indeed very well perceived by the user.

[0008] In a further aspect, it is further noted that the synergy between the use of liquid flavors and water (as a result of wetting the pouch) brings taste perception to a new level while also affecting and dissolving sweeteners such as sugar alcohols, thereby providing additional saliva production.

[0009] The rapid and effective contact of the liquid flavoring with saliva promotes increased saliva secretion, which promotes faster wetting of the pouch, thereby providing the user with an improved wetness of the pouch. This increased saliva secretion can also increase the dissolution of saliva-soluble ingredients, such as sugar alcohols or any active ingredients, providing the user with a stronger initial sweetness sensation.

[0010] An important advantage of the present invention is that it does not require drying of the composition after addition of the liquid flavor composition, so water is added followed by the liquid flavor composition. In an advantageous embodiment of the present invention, the pouch composition further comprises a powdered flavour composition.

[0011] By combining a liquid flavorant composition with a powdered flavorant composition in accordance with the present invention, the user experiences both an initial noticeable burst of flavor and a sustained release of flavor. The liquid flavoring agent is distributed over a large surface area of ​​the provided mixture, which may include, for example, sugar alcohol and water, thereby facilitating effective contact with saliva, which also advantageously promotes flavoring agent release, while the powdered flavoring composition promotes flavoring agent release over a longer period of time, i.e., sustained flavoring agent release.

[0012] A powdered flavoring composition refers to a flavoring composition provided as a solid or contained in a solid matrix. A powdered flavoring composition can be obtained by adding a liquid flavoring to a solid matrix composition, such as a sugar alcohol, to obtain a solid powdered flavoring composition. A powdered flavoring material can be obtained, for example, by a spray drying method.

[0013] Therefore, according to the present invention, the liquid flavor composition is added to the powdered composition after the water, i.e., after the water is added to the powdered composition, the liquid flavor composition is added to the resulting mixture of the powdered composition and water.

[0014] In an advantageous embodiment of the invention, the pouch composition comprises the powdered flavour composition in an amount of at least 1% by weight of the pouch composition, such as at least 3% by weight of the pouch composition, such as at least 5% by weight of the pouch composition.

[0015] In an advantageous embodiment of the present invention, the pouch composition comprises the powdered flavour composition in an amount of at least 1-20% by weight of the pouch composition, such as 3-15% by weight of the pouch composition, such as 5-10% by weight of the pouch composition.

[0016] In an alternative embodiment of the present invention, the pouch composition does not include a powdered flavor composition. In an advantageous embodiment of the invention, the pouch composition comprises the liquid flavouring composition in an amount of at least 0.01% by weight of the pouch composition, such as at least 0.1% by weight of the pouch composition, such as at least 0.5% by weight of the pouch composition.

[0017] In an advantageous embodiment of the invention, the pouch composition comprises the liquid flavouring composition in an amount of 0.01 to 10% by weight of the pouch composition, such as 0.1 to 5% by weight of the pouch composition, such as 0.5 to 3% by weight of the pouch composition.

[0018] In one embodiment of the present invention, the powdered flavor composition and / or the liquid flavor composition comprises at least one flavor compound selected from the group consisting of coconut, coffee, chocolate, vanilla, citrus such as grapefruit, orange, lime, lemon, menthol, licorice, caramel aroma, honey aroma, peanut, walnut, cashew, hazelnut, almond, pineapple, strawberry, raspberry, tropical fruits, cherry, cinnamon, peppermint, wintergreen, spearmint, eucalyptus, and mint, fruit essences such as apple, pear, peach, strawberry, apricot, raspberry, cherry, pineapple, lemongrass, lime, jalapeno, chili (capsaicin), citrus, tobacco flavors, plum essence, blackcurrant, and any combination thereof.

[0019] Essential oils include peppermint, spearmint, menthol, eucalyptus, clove oil, bay oil, anise, thyme, cedar leaf oil, nutmeg, and oils of the fruits mentioned above. The essential oils can be used as liquid flavoring compositions, optionally with the addition of a liquid carrier. To use the essential oils as powdered flavoring compositions, the essential oils must be added to a powdered carrier, for example, granulated with sugar alcohol or water-soluble fiber.

[0020] In an advantageous embodiment of the present invention, the pouch composition comprises a powdered flavour composition. In one embodiment, the pouch composition is a mixture comprising a sugar alcohol, water, and a powdered flavor composition.

[0021] In an advantageous embodiment of the present invention, the powdered flavouring composition comprises a water-soluble carrier. In an alternative embodiment of the present invention, the powdered flavor composition comprises a water insoluble carrier. In one embodiment of the invention, the water soluble carrier comprises or is a sugar alcohol, maltodextrin, gum arabic (acacia), or any combination thereof.

[0022] In an advantageous embodiment of the present invention, the powdered flavour composition comprises the flavour compound in an amount of 10-95% by weight of said powdered flavour composition. In exemplary embodiments, the powdered flavor composition may have a loading (i.e., concentration of flavor compound) of at least 10%, such as 15-30%, for example 20-25%. For some flavor compounds (such as menthol), significantly higher loadings can be used, such as, for example, about 80% or 95%.

[0023] In an advantageous embodiment of the invention, the powdered flavouring provides flavour compounds in an amount of 0.1 to 18% by weight of the pouch composition, such as 0.3 to 14% by weight of the pouch composition, such as 0.5 to 9% by weight of the pouch composition.

[0024] In an advantageous embodiment of the present invention, the liquid flavouring composition comprises a liquid carrier. In one embodiment of the present invention, the liquid carrier is oil or solvent.In one embodiment, the liquid carrier is selected from triacetin, propylene glycol, ethanol, medium chain triglyceride (MCT), and any combination thereof.Medium chain triglyceride (MCT) is known, for example, under the trade name Miglyol (trademark).

[0025] In an advantageous embodiment of the present invention, the liquid flavouring composition comprises the flavouring compound in an amount of 10-100% by weight of the liquid flavouring composition. In an alternative embodiment of the invention, the liquid flavouring composition comprises flavouring compounds in an amount less than 10% by weight of the liquid flavouring composition, such as from 0.1 to 10% by weight of the liquid flavouring composition.

[0026] In an advantageous embodiment of the invention, the liquid flavouring provides flavouring compounds in an amount of 0.01 to 5% by weight of the pouch composition, such as 0.03 to 4% by weight of the pouch composition, such as 0.05 to 3% by weight of the pouch composition.

[0027] In an advantageous embodiment of the present invention, the liquid flavouring composition comprises at least one of mint, eucalyptus, citrus such as lemon, lime, orange or bergamot, liquorice, raspberry, blackcurrant, or any combination thereof.

[0028] In an advantageous embodiment of the invention, the powdered composition comprises at least one sugar alcohol. In one embodiment, xylitol, maltitol, mannitol, erythritol, isomalt, sorbitol, lactitol and their mixtures can be used as sugar alcohol.At least one sugar alcohol can also contain additional sugar alcohols.As an exemplary embodiment, the hydrolyzed hydrogenated starch can be used that contains sorbitol, maltitol and a mixture of additional sugar alcohols.

[0029] In an advantageous embodiment of the invention, the at least one sugar alcohol is chosen from xylitol, maltitol, mannitol, erythritol, isomalt, sorbitol, lactitol, and mixtures thereof.

[0030] In an advantageous embodiment of the invention, the at least one sugar alcohol is chosen from xylitol, maltitol, mannitol, erythritol, isomalt, lactitol, and mixtures thereof.

[0031] In one embodiment of the invention, the at least one sugar alcohol comprises xylitol and / or erythritol. In an advantageous embodiment of the invention, the pouched composition comprises at least two alcohols.

[0032] In one embodiment of the invention, the at least two sugar alcohols are selected from xylitol, maltitol, mannitol, erythritol and isomalt. In an advantageous embodiment of the invention, the pouch composition comprises at least one sugar alcohol in an amount of at least 1% by weight of the composition, such as at least 2% by weight of the composition, such as at least 5% by weight of the composition, such as at least 10% by weight of the composition.

[0033] In an advantageous embodiment of the invention, the pouch composition comprises at least one sugar alcohol in an amount of from 1 to 80% by weight of the composition, such as from 2 to 70% by weight of the composition, such as from 5 to 60% by weight of the composition, such as at least 10 to 50% by weight of the composition.

[0034] In one embodiment of the invention, the pouch composition comprises at least one sugar alcohol in an amount of 5-40% by weight of the composition, such as 5-30% by weight of the composition. In an advantageous embodiment of the invention, the at least one sugar alcohol comprises a DC (directly compressible) grade sugar alcohol.

[0035] In an advantageous embodiment of the invention, at least 50% by weight of the at least one sugar alcohol is a DC (directly compressible) grade sugar alcohol. In one embodiment of the invention, the at least one sugar alcohol comprises a DC (directly compressible) grade sugar alcohol in an amount of 50-100% by weight of the at least one sugar alcohol, such as 60-80% by weight of the at least one sugar alcohol.

[0036] In one embodiment of the invention, the at least one sugar alcohol comprises a non-DC (non-directly compressible) grade sugar alcohol. In an advantageous embodiment of the invention, the powdered composition comprises water-insoluble fibers.

[0037] In an advantageous embodiment of the invention, the powdered composition comprises a sugar alcohol and a water-insoluble fiber. The advantage of using a combination of sugar alcohol, water and water insoluble fiber is that a very appealing soft, moist, moldable texture and mouthfeel is obtained. While the desired texture and mouthfeel is obtained, the produced pouches can still be stored adjacent to each other, for example in a can, without sticking too much to each other which would result in the pouch bursting when removed.

[0038] In an advantageous embodiment of the invention, the water-insoluble fibre is a vegetable fibre. In an advantageous embodiment of the invention, the water insoluble fibre is selected from wheat fibre, pea fibre, rice fibre, maize fibre, oat fibre, tomato fibre, barley fibre, rye fibre, sugar beet fibre, buckwheat fibre, potato fibre, cellulose fibre, apple fibre, cocoa fibre, cellulose fibre, powdered cellulose, bran fibre, bamboo fibre and any combination thereof.

[0039] Powdered cellulose within the scope of the present invention is understood to be cellulose prepared by processing α-cellulose obtained as a pulp from several types of fibrous plant material, such as wood pulp.

[0040] In an advantageous embodiment of the invention, the water-insoluble fibre comprises or consists of a water-insoluble fibre selected from wheat fibre, oat fibre, pea fibre, powdered cellulose, or combinations thereof.

[0041] An advantage of the above embodiment may be that it can promote a relatively efficient release of flavouring. When including a further substance to be released, such as nicotine, efficient release may be promoted. In one embodiment of the invention, the water-insoluble composition comprises or consists of a water-insoluble fiber selected from wheat fiber, oat fiber, pea fiber, or combinations thereof.

[0042] In one embodiment of the invention, the water-insoluble composition comprises or consists of a water-insoluble fiber selected from wheat fiber, oat fiber, or a combination thereof. Non-limiting examples of water insoluble fibers that may be used include Vitacel® WF 600, Vitacel® HF 600, Vitacel® P95, Vitacel® WF 200, Vitacel® L00, Vitacel® Erbsenfaser EF 150, Vitacel® bamboo fiberbaf 90, Vitacel® HF 600, Vitacel® Cellulose L700G, Vitacel® PF200, Vitacel® potatoofiber KF200, Vitacel® bamboo fiberhaf BAF40, Vitacel® Haferfaser / oat fiber HF-401-30 US.

[0043] Non-limiting examples of powdered cellulose that can be used include Vitacel® L00, Vitacel® Cellulose L700G, Vitacel® LC1000, Vitacel® L600-20, Vitacel® L600.

[0044] In one embodiment, the powdered cellulose is not chemically modified, and therefore the powdered cellulose can be a chemically unmodified cellulose fiber, e.g., free of microcrystalline cellulose (MCC).

[0045] In an advantageous embodiment of the invention, the water-insoluble fibres have a water binding capacity of at least 200%, such as at least 300%, such as at least 400%.

[0046] An advantage of the above embodiment is that the high water binding capacity allows for a pouch composition with a high moisture content. Additionally, it has been found that pouch compositions having a high moisture content provide the desired texture and mouthfeel while still allowing the produced pouches to be stored adjacent to one another, for example in a can, without sticking too much to one another which would result in the pouch bursting when removed.

[0047] In one embodiment of the present invention, the water-insoluble fiber has a water binding capacity of 200-1500%, such as 300-1300%, such as 200-800%, such as 300-800%, such as 400-600%.

[0048] In one embodiment of the present invention, the water-insoluble fiber has a water binding capacity of 200 to 1500%, such as 300 to 1300%, such as 300 to 900%, such as 300 to 700%, such as 400 to 700%.

[0049] In one embodiment of the present invention, the water-insoluble fiber has a water binding capacity of 200-1500%, such as 400-1500%, such as 500-1500%, such as 500-1200%, such as 500-1000%.

[0050] In one embodiment of the present invention, the water-insoluble fiber has a water binding capacity of 300-1500%, such as 400-1300%. In one embodiment of the invention, the water insoluble fibre has a density of 50-500 grams per litre, such as 100-400 grams per litre, such as 200-300 grams per litre.

[0051] In one embodiment of the present invention, the water-insoluble fiber has a swelling capacity of at least 5.0 mL / g, such as 5.0 to 20 mL / g. The advantage of the above embodiment is that the amount of water-insoluble fiber can be reduced without compromising the mouthfeel during use: when a certain amount of water-insoluble fiber is substituted for the water-soluble ingredient, the water-insoluble fiber swells during use and prevents the water-soluble ingredient from dissolving, so that the user will not experience a loss of pouch content during use.

[0052] In an advantageous embodiment of the invention, the water-insoluble composition comprises or consists of water-insoluble fibres in an amount between 5 and 50% by weight of the pouch composition and a water content between 15 and 70% by weight of said pouch composition.

[0053] In an advantageous embodiment of the invention, the pouch composition comprises water in an amount of at least 5% by weight of the composition, such as at least 8% by weight of the composition, such as at least 10% by weight of the composition, such as at least 20% by weight of the composition.

[0054] In an advantageous embodiment of the invention, the pouch composition comprises water in an amount of less than 65% by weight of the pouch composition, such as less than 60% by weight of the pouch composition, such as less than 50% by weight of the pouch composition, such as less than 40% by weight of said composition.

[0055] In an advantageous embodiment of the invention, the pouch composition comprises water in an amount of 8-60% by weight of the composition, such as 8-50% by weight of the composition, such as 8-40% by weight of the composition, such as 20-40% by weight of the composition.

[0056] In one embodiment of the invention, the pouch composition comprises water in an amount of 8-65% by weight of the composition, such as 10-65% by weight of the composition, such as 15-65% by weight of the composition, such as 20-65% by weight of the composition.

[0057] In one embodiment of the present invention, the pouch composition has a moisture content of 15-70% by weight of said pouch composition, such as 15-50% by weight of said pouch composition, such as 15-40% by weight of said pouch composition, such as 15-30% by weight of said pouch composition, such as 15-25% by weight of said pouch composition.

[0058] In one embodiment of the invention, the pouch composition comprises water in an amount of 8-60% by weight of the composition, such as 8-50% by weight of the composition, such as 8-40% by weight of the composition, such as 8-30% by weight of the composition.

[0059] In an advantageous embodiment of the invention, the pouch composition comprises water in an amount of 20-65% by weight of the composition, such as 20-60% by weight of the composition, such as 20-50% by weight of the composition, such as 20-40% by weight of the composition.

[0060] In an advantageous embodiment of the invention, the pouch composition comprises water and water insoluble fibre in a weight ratio of 3.0 or less, such as 2.5 or less, such as 2.0 or less, such as 1.5 or less, such as 1.0 or less.

[0061] In one embodiment, the pouch composition comprises water and water insoluble fiber in a weight ratio of 3.0 to 0.2, such as 2 to 0.2, such as 1.5 to 0.5. Thus, the above weight ratio has in the numerator the water content, in weight %, of the pouch composition, and in the denominator the water insoluble fiber content, in weight %, of the pouch composition.

[0062] Having a moisture content within the range of the present invention may promote fast release within an initial fast release period, such as within the first 120 seconds, such as within the first 5 minutes, since the pouch is already wetted or partially wetted with water from the start of use.

[0063] On the other hand, the moisture content should not be too high. Having too high moisture content may affect the liquid diffusion into and out of the pouch. A fully wetted pouch may have lower liquid diffusion into and out of the pouch during use, while a partially wetted pouch may have higher liquid diffusion into and out of the pouch. Therefore, a pouch with low liquid diffusion may have lower release, such as a low initial release of ingredients such as flavors or any active ingredients.

[0064] In one embodiment of the invention, the pouch composition has a moisture content of 60% or less by weight of the pouch composition, such as 50% or less by weight of the pouch composition, such as 40% or less by weight of the pouch composition, such as 30% or less by weight of the pouch composition.

[0065] In one embodiment of the present invention, the pouch composition comprises a total amount of flavor compositions of 10% or less by weight of the pouch composition, such as 8% or less by weight of the pouch composition, such as 5% or less by weight of the pouch composition, the total amount of flavor compositions being the sum of the liquid flavor composition and the powdered flavor composition.

[0066] In an advantageous embodiment of the invention, the pouch composition comprises a water insoluble fiber selected from pea fiber, powdered cellulose and combinations thereof, and a flavoring composition in an amount of up to 10% by weight of the pouch composition.

[0067] An advantage of the above embodiment may be that a relatively efficient release of the flavouring composition may be promoted by the inclusion of pea fibre and / or powdered cellulose. In one embodiment of the present invention, the pouch composition comprises a water insoluble fiber selected from pea fiber, powdered cellulose, and combinations thereof, and a total amount of a flavoring composition in an amount of 0.01-10% by weight of the pouch composition.

[0068] In one embodiment of the invention, the soluble fiber comprises or consists of cereal fiber. In one embodiment of the invention, the soluble fibre comprises or consists of fruit fibre and / or vegetable fibre.

[0069] In an advantageous embodiment of the invention, the pouch composition further comprises nicotine. The use of liquid flavourings according to the provisions of the present invention in combination with nicotine has proven to be very attractive from the user's point of view, for example with respect to liquid menthol or liquid mint flavourings, particularly in those embodiments in which the flavouring partially encapsulates or coats the nicotine / nicotine-containing particles.

[0070] In an advantageous embodiment of the invention, the nicotine is selected from the group consisting of nicotine salts, nicotine free base, nicotine bound to an ion exchanger such as an ion exchange resin such as nicotine polacrilex resin, nicotine inclusion complexes or any non-covalently bound nicotine, nicotine bound to zeolites, nicotine bound to cellulose such as microcrystalline cellulose, or starch microspheres, and mixtures thereof.

[0071] One example of a combination of different types of nicotine is a combination of free base nicotine mixed with polacrilex resin, where some nicotine binds to the ion exchange resin and some nicotine remains unbound.

[0072] Free base nicotine includes nicotine mixed with sugar alcohols, modified calcium carbonate, water soluble fiber, ion exchange resins, and combinations thereof. Nicotine bound to modified calcium carbonate is described in WO 2010 / 121619, which is incorporated herein by reference.

[0073] In an advantageous embodiment of the invention, the nicotine comprises non-salt nicotine. In an advantageous embodiment of the invention, the nicotine comprises free base nicotine.

[0074] A very important advantage of the above embodiment would be that it provides a long shelf life for the pouched product, providing a long life taste and texture. By providing nicotine in free base form, it is easier to achieve a high pH in the pouch composition without the need for significant alkaline pH control agents.

[0075] Therefore, in the above embodiments, the amount of alkaline pH control agent can be reduced without compromising shelf life and long life taste and texture. In an advantageous embodiment of the invention, the nicotine comprises nicotine mixed with an ion exchange resin.

[0076] In one embodiment of the invention, the nicotine comprises nicotine mixed with an ion exchange resin, such as a polacrilex resin, and the nicotine pouch composition further comprises nicotine bound to the ion exchange resin, i.e., a nicotine ion exchange resin complex. Thus, the nicotine can be nicotine mixed with a polacrilex resin, where some nicotine is bound to the ion exchange resin, but some nicotine remains unbound as free base nicotine.

[0077] In an advantageous embodiment of the invention, the nicotine comprises free base nicotine mixed with an ion exchange resin in a weight ratio between the free base nicotine and the ion exchange resin of from 0.1 to 2.0, preferably from 0.5 to 2.0, most preferably from about 0.67 to 1.0.

[0078] In one embodiment of the invention, the nicotine comprises free base nicotine mixed with ion exchange resin in a weight ratio between the free base nicotine and the ion exchange resin of from 1:1 to about 1:10, preferably from 1:2 to 1:6, and most preferably from about 1:4 to 1:5.

[0079] Here, the weight ratio means the ratio of the mass of the first component divided by the mass of the second component. The term mixing ratio may also be used. Thus, in the above embodiments, the nicotine comprises free base nicotine mixed with ion exchange resin in a weight ratio between the free base nicotine and the ion exchange resin of from 0.1 to about 1, preferably from 0.17 to 0.5, and most preferably from about 0.2 to 0.25.

[0080] In one embodiment, the pouch composition comprises water and water insoluble fiber in a weight ratio of 0.2 to 0.8. In an advantageous embodiment of the invention, the nicotine comprises a nicotine salt.

[0081] In one embodiment of the invention, the nicotine salt is selected from nicotine ascorbate, nicotine aspartate, nicotine benzoate, nicotine monotartrate, nicotine bitartrate, nicotine chloride (e.g., nicotine hydrochloride, nicotine dihydrochloride), nicotine citrate, nicotine fumarate, nicotine gensitate, nicotine lactate, nicotine mucate, nicotine laurate, nicotine levulinate, nicotine malate, nicotine perchlorate, nicotine pyruvate, nicotine salicylate, nicotine sorbate, nicotine succinate, nicotine zinc chloride, nicotine sulfate, nicotine tosylate, and hydrates thereof (e.g., nicotine zinc chloride monohydrate).

[0082] In one embodiment of the invention, the nicotine salt comprises or consists of nicotine bitartrate. In an advantageous embodiment of the invention, the nicotine comprises nicotine bound to an ion exchange resin.

[0083] In one embodiment of the invention, the ion exchange resin is a polacrilex resin. In one embodiment of the present invention, the polacrilex resin is Amberlite® IRP64.

[0084] In an advantageous embodiment of the invention, the nicotine comprises synthetic nicotine. In an advantageous embodiment of the invention, the nicotine comprises nicotine isolated from tobacco.

[0085] In an advantageous embodiment of the invention, the pouch composition comprises nicotine in an amount of at least 0.1% by weight of the pouch composition, such as at least 0.2% by weight. In an advantageous embodiment of the invention, the pouch composition comprises nicotine in an amount of 0.1 to 5.0% by weight of the pouch composition, such as 0.2 to 4.0% by weight of the pouch composition, such as 1.0 to 2.0% by weight of the pouch composition.

[0086] In one embodiment of the invention, the pouch composition is substantially homogeneous. The homogeneity of a pouch composition can be assessed by evaluating the distribution of the single components of the composition among the individual pouches.

[0087] For example, the standard deviation of the nicotine content, i.e., the uniformity of the nicotine content (CU), is related to the homogeneity of the pouch composition: pouches prepared from the same pouch composition with a low standard deviation of the nicotine content will have a high homogeneity of the pouch composition, whereas pouches prepared from the same pouch composition with a high standard deviation of the nicotine content will have a low homogeneity of the pouch composition.

[0088] In an advantageous embodiment of the invention, the nicotine content among a series of at least 10 oral pouches of said pouch composition maintains a relative standard deviation (RSD) of not more than 10%, preferably not more than 8%, more preferably not more than 6%, even more preferably not more than 4%, and most preferably not more than 2%.

[0089] In one embodiment of the present invention, the nicotine content among a series of at least 10 oral pouches comprising said pouch composition maintains a relative standard deviation (RSD) of 0.1-10%, preferably 0.1-8%, more preferably 0.1-6%, even more preferably 0.1-4%, and most preferably 0.1-2%.

[0090] By adding the water to the powdered composition followed by the liquid flavor composition, a more homogeneous pouch composition is obtained. In an advantageous embodiment of the invention, the pouch composition is free of tobacco, tobacco fibre and tobacco-derived fibre.

[0091] In some alternative embodiments, the pouch composition may include a trace amount of tobacco. For example, nicotine provided as part of a tobacco such as powdered tobacco is in addition to the free base nicotine. Such tobacco may be included, for example, to provide a tobacco flavor.

[0092] In one embodiment, the pouch composition may include tobacco, tobacco fiber, or tobacco-derived fiber in an amount of 0.1-5.0% by weight of the pouch composition, such as 0.1-3.0% by weight of the pouch composition. Thus, the pouch composition may, in some embodiments, include small amounts of tobacco, but this is in addition to the free base nicotine, and thus the pouch composition is not tobacco-based.

[0093] In one embodiment of the invention, the pouch composition comprises, for example, no tobacco, such as less than 0.1% by weight of the pouch composition, such as less than 0.5% by weight of the pouch composition, such as less than 1.0% by weight of the pouch composition, such as less than 3.0% by weight of the pouch composition, or less than 5.0% by weight of tobacco.

[0094] In one embodiment of the invention, the pouch composition does not include tobacco, tobacco fiber, or tobacco-derived fiber, and therefore in this embodiment, the water-insoluble fiber is a non-tobacco fiber, i.e., does not include tobacco, tobacco fiber, or tobacco-derived fiber.

[0095] In one embodiment of the invention, the pouch composition is free of microcrystalline cellulose (MCC), such as being cellulose-free. In one embodiment of the invention, the pouch composition comprises cellulose and does not comprise microcrystalline cellulose (MCC).

[0096] In an advantageous embodiment of the present invention, the liquid flavouring composition at least partially covers the surface of the powdered composition. In an advantageous embodiment of the present invention, the liquid flavouring composition is at least partially adsorbed onto the surface of the powdered composition.

[0097] In an advantageous embodiment of the invention, the pouch composition has a bulk density of at most 0.8 g / cm3, such as at most 0.7 g / cm3, such as at most 0.6 g / cm3, such as at most 0.5 g / cm3.

[0098] An advantage of the above described embodiment may be that it results in a low density composition. Surprisingly, the combination of water and sugar alcohol did not result in a very dense and compacted unworkable pouch composition, but rather allowed for a relatively light weight and low density composition.

[0099] In an advantageous embodiment of the invention, the pouch composition has a bulk density of 0.2 g / cm3 to 0.8 g / cm3, such as 0.3 g / cm3 to 0.7 g / cm3, such as 0.3 g / cm3 to 0.6 g / cm3, such as 0.4 to 0.5 g / cm3.

[0100] In one embodiment of the present invention, the composition has a bulk density of 0.2 g / cm3 to 0.8 g / cm3, such as 0.2 g / cm3 to 0.7 g / cm3, such as 0.2 g / cm3 to 0.6 g / cm3, such as 0.2 to 0.5 g / cm3.

[0101] In one embodiment of the present invention, the composition has a bulk density of 0.2 g / cm3 to 0.8 g / cm3, such as 0.3 g / cm3 to 0.8 g / cm3, such as 0.4 g / cm3 to 0.8 g / cm3, such as 0.5 to 0.8 g / cm3.

[0102] The density of the pouch composition can be influenced by many parameters, especially the type and amount of sugar alcohol, the type and amount of fiber, the water content, and the mixing time of the following process. For example, varying the amount of water also affects the mobility, such that too much water can lead to a dense and dense pouch formulation, but by selecting a fiber with a high water binding capacity, a higher water content can be at least partially offset. It has also been observed that excessive mixing can lead to a very dense and dense pouch composition.

[0103] In an advantageous embodiment of the invention, the pouch composition further comprises a pH controlling agent, such as a basic pH controlling agent, such as a basic buffering agent. In one embodiment of the invention, the pouch composition further comprises a combination of at least two pH control agents, such as a combination of at least two basic buffering agents, such as a basic buffer pair, such as a combination of at least two basic pH control agents.

[0104] An advantage of the above embodiment may be that more efficient nicotine uptake may be obtained, especially when a basic (alkaline) pH control agent is used. Another advantage of the above embodiment may be that a desirable mouthfeel may be obtained during use.

[0105] In embodiments, by avoiding the use of nicotine salts such as nicotine bitartrate, a lower amount of pH control agent can be applied, but it may still be desirable to further increase the pH by adding a pH control agent.

[0106] In an advantageous embodiment of the invention, the pouch composition comprises an alkaline buffer. As used herein, the term alkaline buffer is used interchangeably with basic buffer, i.e., alkaline is used in the sense of "basic" as opposed to acidic.

[0107] In an advantageous embodiment of the invention, the pouch composition comprises a pH controlling agent in an amount of less than 6% by weight of the pouch composition, such as less than 5% by weight of the pouch composition, such as less than 4% by weight of the pouch composition, such as less than 2% by weight of the pouch composition, such as less than 1% by weight of the pouch composition, such as no pH controlling agent.

[0108] In one embodiment of the present invention, the pouch composition comprises a pH control agent in an amount of 0-6% by weight of the pouch composition, such as 0-5% by weight of the pouch composition, such as 0-4% by weight of the pouch composition, such as 0-3% by weight of the pouch composition, such as 0-2% by weight of the pouch composition, such as 0-1% by weight of the pouch composition.

[0109] In one embodiment of the present invention, the pouch composition comprises a pH control agent in an amount of 0.1 to 6 wt% of the pouch composition, such as 0.1 to 5 wt% of the pouch composition, such as 0.5 to 5 wt% of the pouch composition, such as 0.5 to 4 wt% of the pouch composition, such as 0.1 to 3 wt% of the pouch composition, such as 0.1 to 2 wt% of the pouch composition, such as 0.1 to 1 wt% of the pouch composition.

[0110] In one embodiment of the present invention, the pouch composition includes a pH control agent, for example in an amount of 0.01 to 15% by weight of the pouch composition. In one embodiment of the present invention, the pouch composition comprises a pH control agent in an amount of 0.01 to 15% by weight of the pouch composition, such as 0.5 to 10% by weight of the pouch composition, such as 1 to 10% by weight of the pouch composition, such as 5 to 10% by weight of the pouch composition.

[0111] In an advantageous embodiment of the invention, the pouch composition is adapted to provide a pH of at least 8.0, such as a pH of at least 8.2, such as a pH of at least 8.5, such as a pH of at least 8.7, such as a pH of at least 9.0, when 2.0 grams of the pouch composition is added to 20 mL of 0.02 M potassium dihydrogen phosphate buffer (pH adjusted to 7.4).

[0112] An advantage of the above embodiment may be that relatively efficient nicotine uptake is promoted due to the high pH value obtained. A further advantage of the above embodiments may be that the need for preservatives may be reduced or even eliminated, and that such preservatives may be used in smaller amounts, if not absent.

[0113] The resulting high pH value may also advantageously impart a tingling sensation in the mouth that may be perceived as a desirable mouthfeel, for example, similar to tobacco-based pouch products.

[0114] In an advantageous embodiment of the invention, the pH control agent is selected from the group consisting of acetic acid, adipic acid, citric acid, fumaric acid, glucono-δ-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentaposodium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, magnesium oxide, or any combination thereof.

[0115] In an advantageous embodiment of the invention, the pH control agent is a basic buffer and / or a basic pH control agent such as sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, or any combination thereof.

[0116] In one embodiment of the invention, the pouch composition further comprises a humectant. The humectant may attract and retain water in the oral cavity during use, however, the humectant may also further moderate the release of an active ingredient, such as nicotine, for example to facilitate sustained release.

[0117] In one embodiment of the present invention, the pouch composition further comprises a water retention agent in an amount of 0.5-10% by weight of the pouch composition, such as 0.5-5% by weight of the pouch composition, such as 1-3% by weight of the pouch composition.

[0118] In one embodiment of the invention, the humectants include one or more from the list consisting of glycerol, propylene glycol, alginates, modified starches, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0119] In one embodiment of the invention, the pouch composition further comprises an alginate. In one embodiment of the invention, the pouch composition further comprises glycerol. In one embodiment of the invention, the pouch composition further comprises a modified starch.

[0120] In one embodiment of the invention, the pouch composition further comprises hydroxypropyl cellulose (HPC). An advantage of the above embodiment may be that the pouch composition provides a desirable soft texture during use. Alginate, for example, serves as a water retention agent and thus can attract and retain water in the oral cavity during use.

[0121] In an advantageous embodiment of the invention, the pouch composition further comprises an alginate in an amount of 0.5 to 10% by weight of the pouch composition, such as 1 to 3% by weight. In one embodiment of the invention, the pouch composition further comprises xanthan gum.

[0122] An advantage of the above embodiment may be that the pouch composition provides a desirable soft texture during use. Xanthan gum, for example, serves as a water retention agent and thus may attract and retain water in the oral cavity during use.

[0123] In an advantageous embodiment of the invention, the pouch composition comprises a glidant such as silicon dioxide, for example in an amount of from 0.5 to 5% by weight of the composition, such as from 1 to 3% by weight of the composition. In one embodiment of the invention, the glidant is selected from talc powder, colloidal silica, silicon dioxide, starch, magnesium stearate, and combinations thereof.

[0124] In one embodiment of the invention, the pouch composition further comprises a powdered flavor composition, the powdered composition comprising at least one sugar alcohol, such as at least one sugar alcohol selected from xylitol, maltitol, mannitol, erythritol, isomalt, lactitol, and mixtures thereof.

[0125] In one embodiment of the invention, the pouch composition further comprises a powdered flavor composition, the powdered composition comprising a water insoluble fiber. In one embodiment of the invention, the pouch composition further comprises a powdered flavor composition, wherein the powdered composition comprises at least one sugar alcohol, and wherein the powdered composition comprises a water insoluble fiber.

[0126] In one embodiment of the invention, the pouch composition further comprises a powdered flavor composition, the powdered composition comprising at least one sugar alcohol, such as at least one sugar alcohol selected from xylitol, maltitol, mannitol, erythritol, isomalt, lactitol, and mixtures thereof, and the liquid flavor is at least partially adsorbed onto the surface of the powdered composition.

[0127] In one embodiment of the invention, the pouch composition further comprises a powdered flavoring composition, which comprises at least one sugar alcohol, such as at least one sugar alcohol selected from xylitol, maltitol, mannitol, erythritol, isomalt, lactitol, and mixtures thereof, and the pouch composition further comprises nicotine.

[0128] In an advantageous embodiment of the invention, the composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolyzates, isomalt, or any combination thereof, the composition comprising said sugar alcohol in an amount of 1-80% by weight of the pouch composition, such as 5-70% by weight of the pouch composition, such as 10-60% by weight of the pouch composition.

[0129] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition, and The composition further comprises water insoluble fiber in an amount of from 5 to 50% by weight of the pouch composition, such as from 10 to 30% by weight of the pouch composition.

[0130] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The water-insoluble composition comprises or consists of a water-insoluble fiber, such as a water-insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof.

[0131] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The water insoluble composition comprises or consists of a water insoluble fiber, such as a water insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof, and the pouch composition comprises a flavoring in an amount of 0.01 to 15% by weight of said pouch composition, such as 0.1 to 15% by weight of the pouch composition, such as 1 to 10% by weight of the pouch composition, such as 3 to 10% by weight of the pouch composition.

[0132] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water-insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; The water insoluble composition comprises or consists of a water insoluble fiber, such as a water insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof, and the pouch composition comprises a flavoring in an amount of 0.01-15% by weight of said pouch composition, such as 0.1-15% by weight of the pouch composition, such as 1-10% by weight of the pouch composition, such as 3-10% by weight of the pouch composition, and the flavoring is oil-based.

[0133] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The pouch composition comprises a pH control agent selected from the group consisting of acetic acid, adipic acid, citric acid, fumaric acid, glucono-δ-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentaposodium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, magnesium oxide, or any combination thereof.

[0134] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The pouch composition includes a basic pH controlling agent, such as a basic buffer, and / or a pH controlling agent, such as sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, or any combination thereof.

[0135] In an advantageous embodiment of the invention, the membrane of the pouch comprises water-insoluble fibres of a different origin than those contained in the pouched product. In an advantageous embodiment of the invention, the water-insoluble fiber of the membrane and the water-insoluble fiber of the pouch composition both comprise natural fibers.

[0136] In an advantageous embodiment of the invention, both the water-insoluble fibers of the membrane and the water-insoluble fibers of the pouch composition are natural fibers. In one embodiment of the invention, the pouch composition further comprises a powdered flavoring composition comprising water insoluble fiber and at least one sugar alcohol, such as at least one sugar alcohol selected from xylitol, maltitol, mannitol, erythritol, isomalt, lactitol, and mixtures thereof, the pouch composition further comprises nicotine, and the liquid flavoring is at least partially adsorbed on the surface of the powdered composition.

[0137] In a second aspect, the present invention relates to an oral pouched product comprising a pouch, a powdered composition and a liquid flavouring composition, the liquid flavouring composition covering at least a portion of the surface of the powdered composition.

[0138] Thus, in one embodiment, the liquid flavourant is at least partially adsorbed onto the surface of the powdered composition. In one embodiment of the invention, an oral pouched product of the second aspect is provided according to the oral pouched product of the first aspect of the invention or any of its embodiments, provided that the limitations of claim 1 are not observed.

[0139] In one embodiment of the invention, the oral pouched product of the second aspect is provided according to the oral pouched product of the first aspect of the invention or any of its embodiments. In one embodiment of the invention, the pouch is a pouch membrane.

[0140] In one embodiment of the invention, the pouch is a saliva-permeable membrane. Typically, the pouch membrane includes an opening with characteristic opening dimensions adapted to characteristic dimensions of the pouch composition to retain the pouch composition inside the pouch prior to use and / or to retain a portion of the pouch composition, such as a water-insoluble composition, inside the pouch during use.

[0141] To obtain a pouch membrane with a suitable opening size in view of the pouch composition to be used, the materials of the pouch membrane, including, for example, woven and / or nonwoven fabrics, may be selected accordingly.

[0142] In other words, according to various embodiments, the pouch membrane allows the passage of saliva and prevents or blocks the passage of undissolved composition and water-insoluble fibers. The pouch membrane can be any suitable material, such as woven or nonwoven fabrics (e.g., cotton, fleece, etc.), heat-sealable nonwoven cellulose such as long fiber paper, or other polymeric materials such as synthetic, semi-synthetic, or natural polymeric materials. One example of a suitable material for the pouch membrane is paper made of pulp and a small amount of a wet enhancer. The material suitable for use must provide a semi-permeable membrane layer to prevent the powder or composition from exiting the bag or pouch during use. The suitable material is also one that does not have a significant effect on the release of nicotine from the pouch.

[0143] More specifically, in terms of material, the pouch membrane can be a natural, synthetic, semi-synthetic hydrophilic or hydrophobic membrane. It can be made of one or more biocompatible and physiologically acceptable polymeric materials. Examples of suitable materials for the pouch membrane are cellulose acetate and its derivatives, carboxymethylcellulose, polycellulose esters, other cellulose derivatives including ethylcellulose, propylcellulose, polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyvinyl acetate, methacrylate and acrylate polymers, natural rubber, polycarbonate, polyethylene terephthalate, polyester, polyamide, and nylon. Other suitable materials have been mentioned earlier in this specification.

[0144] Rayon fibers, such as viscose rayon fibers (i.e., regenerated cellulose), may also be used, for example, in combination with an acrylic polymer to act as a binder in the nonwoven material and provide a heat seal for the pouch membrane during its manufacture. Other binders, such as one or more copolymers of vinyl acetate and acrylic acid esters, may also be used.

[0145] Suitable pouch membranes are available under the trade names "Taboka", CatchDry, Ettan, General, Granit, Goteborgs Rape, GrovSnus White, Metropol Kaktus, Mocha Anis, Mocha Mint, Mocha Wintergreen, Kicks, Probe, Prince, Skruf, TreAnkrare, Camel Snus Original, Camel Snus Frost, and Camel Snus Spice. The pouch membrane provides a liquid permeable container of a type that may be considered similar in properties to the mesh-type materials used in the construction of tea bags The desired component of the nicotine composition to be released diffuses through the pouch membrane and into the user's mouth.

[0146] The pouch membrane material may have the form of a net, a sieve, a paper with holes, a permeable cloth, and the like. For example, a pouch material made from rice paper in a net form, or straw paper with holes, may dissolve in the mouth of the user. In some exemplary embodiments, the pouch membrane material may be made using water-dispersible film-forming materials (e.g., binders such as alginate, carboxymethylcellulose, xanthan gum, pullulan, and the like), as well as those materials in combination with materials such as ground cellulose derivatives (e.g., fine grain wood pulp). The preferred pouch material, while water-dispersible or soluble, may be designed and manufactured such that a significant amount of the nicotine content will permeate the pouch material under normal use conditions before the time at which the pouch loses its physical integrity. If desired, flavoring ingredients, disintegration aids, and other desired ingredients may be incorporated into or applied to the pouch material.

[0147] Examples of various types of pouch membrane materials are described in U.S. Patent No. 5,167,244 to Kjerstad. Fleece materials for use as pouch membranes are described, for example, in WO 2008 / 152469, GB 673,587, and EP 2 692 254.

[0148] In one embodiment of the invention, the membrane comprises water-insoluble fiber of a different origin than the water-insoluble fiber contained in the pouched product. In one embodiment of the invention, the water insoluble fiber of the membrane and the water insoluble fiber of the pouch composition both comprise natural fibers.

[0149] In one embodiment of the invention, the water insoluble fibers of the membrane and the water insoluble fibers of the pouch composition are both natural fibers. In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprising said sugar alcohol in an amount of 1-80% by weight of the pouch composition, such as 5-70% by weight of the pouch composition, such as 10-60% by weight of the pouch composition.

[0150] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition, and The composition further comprises water insoluble fiber in an amount of from 5 to 50% by weight of the pouch composition, such as from 10 to 30% by weight of the pouch composition.

[0151] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The water-insoluble composition comprises or consists of a water-insoluble fiber, such as a water-insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof.

[0152] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The water insoluble composition comprises or consists of a water insoluble fiber, such as a water insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof, and the pouch composition comprises a flavoring in an amount of 0.01 to 15% by weight of the pouch composition, such as 0.1 to 15% by weight of the pouch composition, such as 1 to 10% by weight of the pouch composition, such as 3 to 10% by weight of the pouch composition.

[0153] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water-insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; The water insoluble composition comprises or consists of a water insoluble fiber, such as a water insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof, and the pouch composition comprises a flavoring in an amount of 0.01-15% by weight of the pouch composition, such as 0.1-15% by weight of the pouch composition, such as 1-10% by weight of the pouch composition, such as 3-10% by weight of the pouch composition, and the flavoring is oil-based.

[0154] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The pouch composition comprises a pH control agent selected from the group consisting of acetic acid, adipic acid, citric acid, fumaric acid, glucono-δ-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentaposodium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, magnesium oxide, or any combination thereof.

[0155] In an advantageous embodiment of the invention, the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, the composition comprises the sugar alcohol in an amount of from 1 to 80% by weight of the pouch composition, such as from 5 to 70% by weight of the pouch composition, such as from 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The pouch composition includes a basic pH controlling agent, such as a basic buffer, and / or a pH controlling agent, such as sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, or any combination thereof.

[0156] In a third aspect, the present invention relates to a method for producing an oral pouched product, the method comprising the steps of: Providing a powdered composition; mixing water with said powdered composition; adding a liquid flavoring composition to the mixture of water and the powdered composition; and adding the resulting mixture to a saliva-permeable pouch; Includes.

[0157] Thus, when the powdered composition comprises one or more sugar alcohols, the liquid flavoring composition is added subsequent to the one or more sugar alcohols. Similarly, when the powdered composition comprises fiber, the liquid flavoring composition is added subsequent to the one or more fibers. The powdered composition may also comprise a powdered flavoring composition, and in such an embodiment, the liquid flavoring composition is added subsequent to the powdered flavoring composition.

[0158] The present application of liquid flavors when added to form a partial encapsulation or coating of the pouch contents is attractive, particularly when the pouch contents contain a sugar alcohol, which dissolves rapidly upon initial burst of flavor, thereby imparting not only a highly perceived taste impression to the user, but also an attractive release of any active ingredients.

[0159] In one embodiment of the invention, the method further comprises sealing the pouch. In an advantageous embodiment of the invention, nicotine is added to the mixture of water and the powdered composition prior to adding the liquid flavouring composition.

[0160] In an advantageous embodiment of the present invention, the glidant is added after the addition of the liquid flavour composition. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0161] As used herein, the term "pouch composition" refers to a pouched product, i.e. a composition for use in a pouch for oral use.

[0162] As used herein, the term "pouch" is intended to mean a container typically formed by a web of fibrous material surrounding a cavity. The pouch may be designed for administering a compound such as nicotine into the oral cavity. In any case, it is suitable for use in the oral cavity and is non-toxic and non-water soluble. The fibrous material may form, for example, a woven or non-woven web or fabric. The pouch may be formed, for example, by sealing two corresponding parts of a web or fabric together along their edges to form a cavity for the pouch composition. To release the flavorant (i.e., the flavorant compound and any further ingredients to be released), the pouch is water permeable so that saliva from the oral cavity penetrates the pouch and enters the cavity, where it comes into contact with the flavorant composition, thereby releasing the flavorant from the oral pouch.

[0163] Other active ingredients to be applied in the pouch composition within the scope of the present invention include, but are not limited to, the group consisting of phytochemicals such as resveratrol and anthocyanins; herbs such as green tea and thyme; antioxidants such as polyphenols; micronutrients; mouth moisteners such as acids; throat soothing ingredients; appetite suppressants; breath fresheners such as zinc compounds or copper compounds; dietary supplements; cold preventatives; cough suppressants; vitamins such as vitamin A, vitamin C or vitamin E; minerals such as chromium; metal ions; alkaline materials such as carbonates; salts; dental treatments such as herbs, remineralizing agents, antibacterial agents, anti-caries agents, plaque acid buffers, teeth whitening agents, stain removers or desensitizing agents; and combinations thereof.

[0164] In one embodiment of the invention, the active ingredient is selected from the group consisting of a dipeptide, a tripeptide, an oligopeptide, a decapeptide, a decapeptide KSL, a decapeptide KSL-W, an amino acid, a protein, or any combination thereof.

[0165] In one embodiment of the invention, the active ingredient comprises probiotic bacteria such as Lactobacillus, Bifidobacterium, Lactococcus, Streptococcus, Leuconostoccus, Pediococcus or Enterococcus.

[0166] As used herein, the term "powder composition" refers to a composition in the form of a powder, i.e. as particulate matter having a relatively small particle size, for example between 1 and 1200 micrometers. In particular, powder composition does not refer to powdered tobacco.

[0167] As used herein, the term "flavor" is understood to have its ordinary meaning within the art. Flavor is provided by flavor compounds and may be included in liquid or powdered flavor compositions. Thus, flavor does not include, by definition, sweeteners (such as sugars, sugar alcohols, and high-intensity sweeteners), acids that impart pure acidity / sourness, or compounds that impart pure saltiness (e.g., NaCl) or pure bitterness. Flavor enhancers include substances that impart only saltiness, bitterness, or sourness. When flavor enhancers are included in the pouch composition, they can be added as part of the flavor composition or separately. Thus, flavor enhancers include, for example, NaCl, citric acid, ammonium chloride, and the like.

[0168] As used herein, the term "powdered flavor composition" refers to a flavor composition in powder form. It includes flavors that are solid in nature, or flavors immobilized in or contained within a powdered carrier, such as a water-soluble or water-insoluble carrier. Thus, a powdered flavor composition may include a solid carrier and / or a flavor enhancer, but always includes at least one flavor compound. Powdered flavor compositions include, for example, encapsulated flavors. Some powdered flavor compositions include several flavor ingredients to obtain a desired flavor profile, while other powdered flavor compositions include only a single flavor ingredient.

[0169] As used herein, the term "liquid flavor composition" refers to a flavor composition in liquid form. It includes flavors that are essentially in liquid form and flavor ingredients that are liquid because of the liquid carrier. As such, liquid flavor compositions do not include encapsulated flavors. Liquid flavor compositions may include liquid carriers and / or flavor enhancers, but always include at least one flavor compound. Some liquid flavor compositions include several flavor ingredients to obtain a desired flavor profile, while other liquid flavor compositions include only a single flavor ingredient.

[0170] As used herein, the term "humectant" is understood as a moisturizing agent used to attract moisture or water in the form of saliva. Humectants typically include compositions that are suitably hygroscopic. In some cases, humectants may also be referred to as moistening agents, since they act to attract moisture. Examples of humectants include glycerol, propylene glycol, alginate, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin, xanthan gum, and the like.

[0171] As used herein, the term "water soluble" refers to a relatively high water solubility, e.g., a water solubility of a water soluble composition or substance greater than 5 grams per 100 mL of water, measured at 25 degrees Celsius and a pH of 7.0. When referring to a "soluble" composition or substance, water soluble is meant unless otherwise specified.

[0172] As used herein, the term "water-insoluble" refers to a relatively low water solubility, for example, a water soluble composition or substance having a water solubility of less than 0.1 grams per 100 mL of water, measured at 25 degrees Celsius and a pH of 7.0. When referring to "insoluble", water insolubility is meant unless otherwise specified.

[0173] As used herein, the term "nicotine" refers to nicotine used as a purified / isolated substance. In particular, nicotine does not refer to tobacco materials that contain nicotine.

[0174] As used herein, the term "free base nicotine" refers to nicotine in unprotonated form, and therefore does not include nicotine salt and nicotine provided as a complex of nicotine and ion exchange resin.However, free base nicotine can be mixed with an amount of ion exchange resin or water-soluble composition such as sugar alcohol or water-soluble fiber.Free base nicotine includes both free base nicotine extracted from tobacco and synthetically produced free base nicotine, but free base nicotine is not provided in the form of tobacco or powdered tobacco.Typically, free base nicotine is provided as a liquid.

[0175] As used herein, the term "initial" can refer to the first few minutes of use, such as the first 5 minutes of use. Generally, the pouch has an opening whose characteristic opening dimensions match the characteristic dimensions of the pouch composition to retain the pouch composition within the pouch prior to use and / or to retain a portion of the pouch composition, such as a water-insoluble composition, within the pouch during use.

[0176] The materials of the pouch membrane, including, for example, woven and / or nonwoven fabrics, may be appropriately selected to obtain a pouch membrane with a suitable opening size in view of the pouch composition to be used. In other words, according to various embodiments, the pouch membrane allows the passage of saliva and prevents or blocks the passage of undissolved pouch composition. The pouch membrane can be any suitable material, such as woven or nonwoven fabric (e.g., cotton, fleece, etc.), heat-sealable nonwoven cellulose, or other polymeric materials, such as synthetic, semi-synthetic, or natural polymeric materials. One example of a suitable material for the pouch is paper made of pulp and a small amount of wet enhancer. The material suitable for use must provide a semi-permeable membrane layer to prevent the powder or composition from exiting the bag or pouch during use. The suitable material is also one that does not have a significant effect on the release of flavor from the pouch.

[0177] The pouch composition is filled into the pouch and maintained within the pouch by sealing. An ideal pouch would be chemically and physically stable, pharma- ceutically acceptable, insoluble in water, capable of being filled with powder and sealed, providing a semipermeable membrane layer to prevent the powder from exiting the bag, but allowing saliva and ingredients from the pouch composition within the pouch, such as flavorings, dissolved therein or suspended in small enough amounts, to pass through the pouch.

[0178] The pouch can be placed in the mouth by a user, after which saliva enters the pouch and flavorings and other ingredients that are soluble in the saliva begin to dissolve and are carried along with the saliva out of the pouch and into the mouth where the nicotine can be absorbed.

[0179] According to one embodiment of the present invention, the pouch composition includes one or more pH controlling agents, such as a buffering agent. In one embodiment of the invention, the pH control agent is selected from the group consisting of acetic acid, adipic acid, citric acid, fumaric acid, glucono-δ-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentaposodium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, magnesium oxide, or any combination thereof.

[0180] According to various embodiments of the present invention, one or more sugar alcohols may be included in the pouch as part of the pouch composition, for example, as a carrier or part thereof, as a humectant, or as a sweetener.Suitable sugar alcohols include sugar alcohols selected from the group of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof.

[0181] In one embodiment of the present invention, the pouch composition comprises a high intensity sweetener. Preferred high intensity sweeteners include, but are not limited to, sucralose, aspartame, salts of acesulfame such as acesulfame potassium, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizin, dihydrochalcones, thaumatin, monellin, stevioside, and the like, either alone or in combination.

[0182] In one embodiment of the invention, the pouch composition comprises sugar and / or non-sugar sweeteners, such as sugar alcohols. In one embodiment of the present invention, the pouch composition comprises sugar and / or sugarless sweeteners in an amount of 1.0 to about 80% by weight of the pouch composition, more typically comprising 5 to about 70% by weight of the pouch composition, and more commonly comprising 10 to 30% by weight of the pouch composition or 5 to 25% by weight of the pouch composition. In some other embodiments, the sugar and / or sugarless sweeteners comprise 10 to 60% by weight of the pouch composition, or 10 to 50% by weight of the pouch composition. The sugar and / or sugarless sweeteners may function not only as sweeteners but also as humectants. In some embodiments, the inclusion of certain ingredients can further limit the about amounts of sugar and / or sugarless sweeteners. In some embodiments, the content of sugar and / or non-sugar sweeteners in the pouch composition is 20% or less by weight of the pouch composition, such as 15% or less by weight of the pouch composition, such as 10% or less by weight of the pouch composition, such as 5% or less by weight of the pouch composition.

[0183] Sweeteners can often support the flavor profile of a pouch composition. Sugar sweeteners generally include, but are not limited to, sugar-containing ingredients commonly known in the pouch art, such as sucrose, dextrose, maltose, saccharose, lactose, sorbose, dextrin, trehalose, D-tagatose, dry invert sugar, fructose, levulose, galactose, corn syrup solids, glucose syrup, hydrogenated glucose syrup, etc., either alone or in combination. These sugar sweeteners may also be included as humectants.

[0184] The sweetener may be used in combination with sugarless sweeteners. Generally, sugarless sweeteners include sugar-free ingredients that are generally known to have sweetening properties, including, but not limited to, sugar alcohols such as sorbitol, mannitol, xylitol, hydrogenated starch hydrolysates, maltitol, isomalt, erythritol, lactitol, alone or in combination. These sugarless sweeteners may also be included as humectants.

[0185] In one embodiment of the present invention, the pouch composition further comprises water-soluble fiber. Non-limiting examples of water-soluble fiber include inulin, polydextrose, and psyllium plant fiber. Other water-soluble dietary fibers may also be used.

[0186] The pouch composition comprises at least a liquid flavoring composition, in the sense that it is added according to the provisions of the present invention. It may be in a non-liquid state in the final pouch composition. The pouch composition may optionally further comprise a powdered flavoring composition. The pouch composition typically comprises the flavoring composition in an amount of 0.01-15% by weight of the total composition of the pouch, such as 0.01-5% by weight of the total composition.

[0187] Non-exhaustive examples of flavor compounds suitable for embodiments of the present invention are coconut, coffee, chocolate, vanilla, grapefruit, orange, lime, menthol, licorice, caramel aroma, honey aroma, peanut, walnut, cashew, hazelnut, almond, pineapple, strawberry, raspberry, tropical fruits, cherry, cinnamon, peppermint, wintergreen, spearmint, eucalyptus, and fruit essences such as mint, apple, pear, peach, strawberry, apricot, raspberry, cherry, pineapple, lemongrass, lime, jalapeno, chili (capsaicin), citrus, tobacco flavors, blackcurrant, and plum essence. Essential oils include peppermint, spearmint, menthol, eucalyptus, clove oil, bay oil, anise, thyme, cedar leaf oil, nutmeg, and oils of the fruits listed above.

[0188] According to a further embodiment of the present invention, the pouch composition may comprise an active pharmaceutical ingredient selected from the group consisting of antihistamines, smoking cessation agents, medications used in diabetes, decongestants, peptides, pain relievers, antacids, anti-nausea agents, statins, or any combination thereof.

[0189] In one embodiment of the invention, the active pharmaceutical ingredient is selected from the group consisting of cetirizine, levocetirizine, nicotine, nicotine polacrilex, nicotine in combination with an alkaline agent, metformin, metformin HCL, phenylephrine, GLP-1, exenatide, MC-4 receptor antagonist, PPY(3-36), decapeptide, KSL-W (acetate), fluoro, chlorhexidine, or any combination thereof.

[0190] In one embodiment of the invention, the active pharmaceutical ingredient is selected from the group consisting of loratadine, desloratadine, nicotine tartrate, nicotine in combination with caffeine, nicotine antagonists, combinations thereof or compounds containing one or more of these, pseudoephedrine, flurbiprofen, paracetamol, acetylsalicylic acid, ibuprofen, antacids, cimetidine, ranitidine, ondansetron, granisetron, metoclopramide, simvastatin, lovastatin, fluvastatin, acyclovir, benzydamine, rimonabant, varenicline, sildenafil, naltrexone, fluoride in combination with fruit acids, derivatives, salts or isomers of chlorhexidine or any combination thereof.

[0191] In one embodiment of the present invention, the active pharmaceutical ingredient is selected from the therapeutic group consisting of: antipyretics, antiallergics, antiarrhythmics, appetite suppressants, anti-inflammatory agents, bronchodilators, cardiovascular drugs, coronary artery dilators, cerebral dilators, peripheral vasodilators, anti-infectives, psychotropic drugs, antimanic drugs, stimulants, decongestants, gastrointestinal sedatives, sexual dysfunction drugs, bactericides, antianginal substances, vasodilators, antihypertensives, vasoconstrictors, migraine treatments, antibiotics, tranquilizers, antipsychotics, Antineoplastics, Anticoagulants, Hypnotics, Sedatives, Antiemetics, Antivomiting, Anticonvulsants, Neuromuscular, Hyperglycemic and Hypoglycemic, Thyroid and Antithyroid, Diuretics, Anticonvulsants, Uterine relaxants, Anorectics, Antispasmodics, Anabolic, Erythropoiesis Stimulants, Antiasthmatics, Expectorants, Antitussives, Mucolytics, Antiurethral, ​​Dental vehicles, Mouth fresheners, Antacids, Diuretics, Intestinal regulators, β-blockers, Teeth whitening agents, Enzymes, Coenzymes, Proteins, Energy boosters Booster), fiber, probiotics, prebiotics, antibacterials, NSAIDs, antitussives, decongestants, antihistamines, antidiarrheals, hydrogen antagonists, proton pump inhibitors, general non-selective CNS depressants, general non-selective CNS stimulants, selective CNS function enhancers, antiparkinsonian agents, narcotic analgesics, antipyretics, psychopharmacological agents, diagnostic sex hormones allergens, antifungals, chronic obstructive pulmonary disease (COPD) or any combination thereof.

[0192] In one embodiment of the present invention, the active pharmaceutical ingredient is selected from the group consisting of ACE inhibitors, antianginal drugs, antiarrhythmic drugs, antiasthmatic drugs, anticholesterol drugs, analgesics, anesthetic drugs, anticonvulsants, antidepressants, antidiabetic drugs, antidiarrheal drugs, detoxifying drugs, antihistamines, antihypertensive drugs, antiinflammatory drugs, antilipidemic drugs, antimanic drugs, antinausea drugs, antistroke drugs, antithyroid drugs, antineoplastic drugs, antiviral drugs, acne drugs, alkaloids, amino acid preparations, antitussive drugs, antiuricemic drugs, antiviral drugs, anabolic agents, systemic and non-systemic anti-infective drugs, antineoplastic drugs, antiparkinsonian drugs, antirheumatic drugs, appetite enhancers, bioresponsiveness regulators, blood regulators, bone metabolism regulators, cardiovascular drugs, central nervous system stimulants, cholinesterase inhibitors, contraceptives, decongestants, and dietary supplements. Dopamine receptor agonists, drugs for treating endometriosis, enzymes, drugs for treating erectile dysfunction such as sildenafil citrate currently sold as Viagra (trademark), fertility drugs, gastrointestinal drugs, homeopathic medicines, hormones, drugs for treating hypercalcemia and hypocalcemia, immunomodulators, immunosuppressants, migraine drugs, drugs for treating motion sickness, muscle relaxants, drugs for treating obesity, drugs for treating osteoporosis, uterotonics, parasympathetic inhibitors, parasympathomimetics, prostaglandins, psychotherapeutic drugs, respiratory agents, sedatives, smoking cessation aids such as bromocriptine and nicotine, sympatholytics, tremor drugs, urinary tract drugs, vasodilators The therapeutic agent is selected from the group consisting of drugs, laxatives, antacids, ion exchange resins, antipyretics, appetite suppressants, expectorants, anxiolytics, antiulcer drugs, anti-inflammatory drugs, coronary dilators, cerebral dilators, peripheral vasodilators, psychotropic drugs, stimulants, antihypertensive drugs, vasoconstrictors, antimigraine drugs, antibiotics, tranquilizers, antipsychotics, antineoplastic drugs, anticoagulants, antithrombotic drugs, hypnotics, antiemetics, antinausea drugs, anticonvulsants, neuromuscular drugs, hyperglycemic and hypoglycemic drugs, thyroid and antithyroid drugs, diuretics, anticonvulsants, thyroid relaxants, antiobesity drugs, erythropoiesis stimulants, antiasthmatic drugs, antitussives, mucolytics, DNA and gene modifying drugs and combinations thereof.

[0193] In one embodiment of the invention, the active pharmaceutical ingredient is selected from the group consisting of an antihistamine, a decongestant, a smoking cessation aid, a type II diabetes medication, or any combination thereof. In an embodiment of the invention, the active pharmaceutical ingredient is selected from the group consisting of ephedrine, pseudoephedrine, caffeine, loratadine, sildenafil, simvastatin, sumatriptan, acetaminophen, calcium carbonate, vitamin D, ibuprofen, aspirin, alginic acid in combination with aluminum hydroxide and sodium bicarbonate, ondansetron, tibolone, rimonabant, varenicline, an allergen, sitagliptin or any derivatives thereof, salts thereof, isomers thereof, combinations thereof, or compounds comprising one or more of these.

[0194] In various embodiments of the present invention, the pouch composition comprises a controlled release composition for controlling the release of the pouch composition and / or portions thereof, particularly nicotine and flavorings. According to various embodiments, the controlled release composition may be selected from the group consisting of metal stearates, modified calcium carbonate, hydrogenated vegetable oils, partially hydrogenated vegetable oils, polyethylene glycols, polyoxyethylene monostearate, tallow, silicates, silicon dioxide, talc, magnesium stearate, calcium stearate, fumed silica, powdered hydrogenated cottonseed oil, hydrogenated vegetable oils, hydrogenated soybean oil, emulsifiers, triglycerides, and mixtures thereof. In particular, metal stearates such as magnesium stearate may be advantageous.

[0195] The controlled release composition may be added to the pouch composition in a variety of ways. In one embodiment of the invention, the pouch composition does not include triglycerides. For example, the controlled release composition can be added by fully powder mixture during the last few minutes of final mixing.

[0196] Alternatively, the controlled release composition may be added after the granulation step of the granulated premix. Additionally, the controlled release composition may be added as part of the pouch composition, or even as two or more parts of the pouch composition. When combined with a combination of nicotine components and flavoring compounds, more complex and tailored release profiles of nicotine and flavorings can be obtained.

[0197] A controlled release composition such as magnesium stearate may have an occlusive effect and may be used to control the release of nicotine and the dissolution rate of the pouch. EXAMPLES

[0198] Example 1A - Preparation of a pouch designed for administration of nicotine The material of the pouch is a heat-sealable nonwoven cellulosic material such as filament paper, etc. Pouches not in the form of a nonwoven cellulosic fabric may also be used in accordance with the present invention.

[0199] The powder is filled into a pouch and maintained within the pouch by a seal. Example 1B - Preparation of a pouch designed for administration of nicotine The pouch material is manufactured using rayon fibers, such as viscose rayon staple fibers. The pouch membrane is heat sealed along its edges except for an opening at one end to the interior cavity formed by the pouch membrane.

[0200] The powder is filled into a pouch and maintained within the pouch by a seal. Example 2A - Pouch Pouches PNN1-PNN5 are prepared containing the powdered compositions outlined in Table 1. The pouches are manufactured as follows.

[0201] The powdered ingredients, including powdered flavors (if any), are mixed for 2 minutes using a planetary Bear Varimixer mixer. Then, with the mixer running, the water is slowly added, followed by the liquid flavors. Finally, the silicon dioxide is added and mixed for about 1 minute. The total mixing time is about 30 minutes.

[0202] The final powder composition is filled into pouches (target fill weight 500 mg powder per pouch). The pouch material of Example 1A is used, made from long fiber paper. The powder is filled into the pouch and maintained in the pouch by sealing.

[0203] The material of the pouch is a heat-sealable nonwoven cellulosic material such as filament paper, etc. Pouches not in the form of a nonwoven cellulosic fabric may also be used in accordance with the present invention. The pouch material of Example 1B can also be used.

[0204] The powder is filled into a pouch and maintained within the pouch by a seal.

[0205] [Table 1]

[0206] Pouch Contents: 500mg total. An example of the xylitol that can be used is the product name "Xylitab (registered trademark) 200".

[0207] Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0208] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0209] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0210] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0211] Pouches PNN1-PNN5 demonstrate that different pouches can be produced having a moisture content of at least 10% by weight of the pouch composition. Example 2B - Pouch Pouches PNN11 to PNN15 are produced in the same manner as pouches PNN1 to PNN5 of Example 2A.

[0212] Pouches PNN11-PNN15 are prepared containing the powdered compositions outlined in Table 2.

[0213] [Table 2]

[0214] Pouch Contents: 500mg total. The applied isomalt is for example GalenIQ™ 720. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0215] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0216] Sodium alginate is used as a water retention agent. Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0217] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0218] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0219] Pouches PNN11 to PNN15 exhibit different moisture contents of at least 10% by weight of the pouch composition. Although the moisture content is varied, the ratio of the amount of added purified water to the amount of fiber remains constant.

[0220] Example 2C - Pouch Pouches PNN21 to PNN25 are produced in the same manner as pouches PNN1 to PNN5 of Example 2A.

[0221] [Table 3]

[0222] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0223] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0224] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium alginate is used as a water retention agent.

[0225] Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0226] Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0227] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0228] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0229] Pouches PNN21 to PNN24 show the use of different sugar alcohols. Pouch PNN21 illustrates the use of, for example, microcrystalline cellulose (MCC) instead of wheat fiber.

[0230] Pouch PNN25 does not contain sugar alcohols. Pouches PNN26-PNN28 show combinations of two sugar alcohols and various amounts of liquid and powdered flavor composition (if any).

[0231] Example 2D - Pouch Pouches PNN30, PNN31 and Comparative P1 (Comp. P1) are produced in the same manner as pouches PNN1 to PNN5 in Example 2A. Pouch P2 (Comp. P2) is also produced in the same manner as pouches PPC1 to PPC5 described in Example 4A.

[0232] [Table 4]

[0233] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0234] Sodium alginate is used as a water retention agent. Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0235] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0236] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0237] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0238] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0239] Pouch PNN31 represents a pouch that does not contain alginate. Comparative pouches P1-P2 (Comp. P1-P2) represent equivalent pouches containing only powdered flavoring with or without nicotine.

[0240] Example 3A - Nicotine Premix I - Resin Water was placed in a Stephan mixer (vacuum premix), nicotine was weighed and added, the mixer was closed and mixed for 5 minutes. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and mixed for 10-60 minutes.

[0241] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set out in Table 5 below.

[0242] [Table 5]

[0243] Example 3B - Nicotine Premix II - Resin Water was placed in a 60 liter planetary Bear Varimixer mixer and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0244] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set out in Table 6 below.

[0245] [Table 6]

[0246] Total processing time was 20 minutes. Example 3C - Nicotine Premix III - Resin Water was placed in a 60 liter planetary Bear Varimixer mixer and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0247] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set forth in Table 7 below.

[0248] [Table 7]

[0249] Total processing time was 20 minutes. Example 3D - Nicotine Premix IV - Resin Water was placed in a 60 liter planetary Bear Varimixer mixer and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0250] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set forth in Table 8A below.

[0251] [Table 8]

[0252] Total processing time was 20 minutes. Example 2E - Nicotine Premix V-Resin Water was placed in a 60 liter planetary Bear Varimixer mixer and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0253] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set forth in Table 8B below.

[0254] [Table 9]

[0255] Total processing time was 20 minutes. Example 2F - Nicotine Premix VI - Resin Water was placed in a 60 liter planetary Bear Varimixer mixer and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0256] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set forth in Table 8C below.

[0257] [Table 10]

[0258] Total processing time was 20 minutes. Example 2G - Nicotine Premix VII - Resin Water was placed in a 60 liter planetary Bear Varimixer mixer and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. Ion exchange resin Amberlite® IRP64 was then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0259] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set forth in Table 8D below.

[0260] [Table 11]

[0261] Total processing time was 20 minutes. Example 2H-Nicotine Premix VIII-Resin A 60 liter planetary Bear Varimixer mixer was charged with water and nicotine was weighed and added. The mixer was stirred at low speed for 1 minute at ambient temperature. The ion exchange resin Amberlite® IRP64 and fibers were then weighed and added to the mixer. The mixer was closed and stirred at high speed for 5 minutes, opened and scraped down as necessary. Finally, the mixer was stirred at high speed for an additional 5 minutes.

[0262] Thereby, a mixture of nicotine and cation exchange resin was prepared from the components set forth in Table 9 below.

[0263] [Table 12]

[0264] Total processing time was 20 minutes. Example 4A - Pouch Pouches PPC6 and PPC7 are prepared as follows.

[0265] The fiber and water are mixed for 5 minutes using a planetary Bear Varimixer mixer. The following ingredients are then added thereafter with continuous mixing: first, nicotine bitartrate xH2O (NBT, 32.5% nicotine content) or nicotine polacrilex resin (NPR, 15.9% nicotine content), if applicable (mixed for 2 minutes), then the remaining ingredients except for the liquid flavor composition and glidant, if any (mixed for 2 minutes), then the liquid flavor composition, if any (mixed for 1 minute), then the glidant, if any (mixed for 1 minute). The total mixing time is 9-11 minutes.

[0266] The final powder composition is filled into pouches (target fill weight 500 mg powder per pouch). The pouch material of Example 1A is used, made from long fiber paper. The powder is filled into the pouch and maintained in the pouch by sealing.

[0267] The material of the pouch is a heat-sealable non-woven cellulose, such as a filament paper. Pouches not in the form of a non-woven cellulose fabric can also be used according to the invention. The pouch material of Example 1B can also be used.

[0268] The powder is filled into a pouch and maintained within the pouch by a seal. Nicotine premix containing pouches PPC1-PPC5 are prepared containing the powder compositions outlined in Table 10. The pouches are manufactured as follows.

[0269] The fiber and water are mixed for 5 minutes using a planetary Bear Varimixer mixer. The following ingredients are then added successively with continuous mixing: nicotine premix (mixed for 2 minutes), then the remaining ingredients except for the liquid flavor composition and glidant, if present (mixed for 2 minutes), then the liquid flavor composition, if present (mixed for 1 minute), then the glidant, if present (mixed for 1 minute). Total mixing time is 9-11 minutes.

[0270] The final powder composition is filled into pouches (target fill weight 500 mg powder per pouch). Use the pouch material from Example 1A made from long fiber paper. The powder is filled into a pouch and maintained within the pouch by sealing. The pouch material of Example 1B can also be used.

[0271] The material of the pouch is a heat-sealable nonwoven cellulosic material such as filament paper, etc. Pouches not in the form of a nonwoven cellulosic fabric may also be used in accordance with the present invention. The powder is filled into a pouch and maintained within the pouch by a seal.

[0272] [Table 13]

[0273] Pouch Content: 500mg total, i.e. nicotine concentration of 19.2mg / g. An example of the xylitol that can be used is the product name "Xylitab (registered trademark) 200".

[0274] Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0275] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0276] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium alginate is used as a water retention agent.

[0277] Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0278] Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0279] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0280] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0281] Pouches PPC1-PPC5 demonstrate that different pouches can be made using free base nicotine with a moisture content of at least 10% by weight of the pouch composition. Pouches PPC6 and PPC7 have similar moisture contents as PPC1 but use nicotine salts and nicotine complexed with ion exchange resins.

[0282] Example 4B - Pouch Nicotine premix containing pouches PPC11-PPC15 are prepared containing the powder compositions outlined in Table 11. The pouches are manufactured as follows.

[0283] The fiber and powder ingredients (except for the glidant) are mixed for 2 minutes using a planetary Bear Varimixer mixer. The nicotine premix is ​​then added and mixed for 2 minutes. The water is then added and mixed for 5 minutes, followed by the liquid flavor composition (mixed for 1 minute) and the glidant (if present) (mixed for 1 minute). The total mixing time is 9-11 minutes.

[0284] [Table 14]

[0285] Pouch Contents: 500mg total. The isomalt applied is, for example, GalenIQ™ 720. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0286] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0287] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium alginate is used as a water retention agent.

[0288] Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0289] Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0290] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0291] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0292] Pouches PPC11 to PPC13, PPC15 exhibit different moisture contents of at least 10% by weight of the pouch composition. Although the moisture content is varied, the ratio of the amount of added purified water to the amount of fiber remains constant.

[0293] Example 4C - Pouch Pouches PPC21-PPC25 are prepared similarly to pouches PPC11-PPC15 of Example 4B.

[0294] [Table 15]

[0295] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0296] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0297] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium alginate is used as a water retention agent.

[0298] Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0299] Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0300] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0301] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0302] Pouch PPC21 illustrates the use of, for example, microcrystalline cellulose (MCC) instead of wheat fiber. Pouch PPC22 demonstrates the use of a combination of a nicotine-ion exchange resin premix and a nicotine-sugar alcohol premix.

[0303] Pouches PPC23-PPC26 show the use of various amounts of buffering agent (here sodium carbonate). With more basic buffering agent to achieve a more alkaline environment, the need for a preservative (here potassium sorbate) is reduced and therefore omitted in PPC25-PPC26 which have the highest amount of alkaline buffering agent.

[0304] Pouch PPC27 illustrates the use of liquid flavor compositions only. Pouch PPC28 illustrates the use of different amounts of liquid and powdered flavorings. Example 4D - Pouch Pouches PPC31-PPC32 were prepared similarly to pouches PPC1-PPC5 of Example 4A, but using Nicotine Premix I and III, respectively.

[0305] Pouches PPC33 to PPC37 are manufactured as follows. Weigh out the nicotine and sugar alcohol (xylitol, sorbitol, maltitol, etc.). Slowly add the nicotine to the sugar alcohol powder while stirring (Kitchenaid mixer operates at about 30 RPM for about 30 minutes). Sift the resulting granules and place on a tray. Dry the resulting powder overnight at ambient temperature and then sieve to obtain the nicotine-sugar alcohol premix. It is also possible to add a certain amount of water to the nicotine before mixing with the sugar alcohol. Such water will then evaporate during drying.

[0306] The fiber and water are mixed for 5 minutes using a planetary Bear Varimixer mixer. The following ingredients are then added successively with continuous mixing: powder ingredients except for the nicotine premix (mixed for 2 minutes), the nicotine-sugar alcohol premix (mixed for 2 minutes), then the liquid flavor composition (mixed for 1 minute), and finally the glidant (if any) (mixed for 1 minute). The total mixing time is 9-11 minutes.

[0307] The final powder composition is filled into pouches (target fill weight pouch: 500 mg powder). The pouch material of Example 1A is used, made from long fiber paper. The powder is filled into the pouch and kept there by sealing. The pouch material of Example 1B can also be used.

[0308] The material of the pouch is a heat-sealable nonwoven cellulosic material such as filament paper, etc. Pouches not in the form of a nonwoven cellulosic fabric may also be used in accordance with the present invention. The powder is filled into a pouch and maintained within the pouch by a seal.

[0309] [Table 16-1]

[0310] [Table 16-2]

[0311] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0312] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0313] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium alginate is used as a water retention agent.

[0314] Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0315] Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0316] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0317] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0318] Pouches PPC31-PPC32 demonstrate the use of other nicotine premixes. Pouches PPC33 to PPC35 demonstrate the use of nicotine pre-mixed with different sugar alcohols.

[0319] Pouches PPC36-PPC37 demonstrate the use of nicotine premixed with different soluble fibers. Example 4E-Pouch Pouches PPC41 to PPC46 are produced in the same manner as pouches PPC1 to PPC5 of Example 4A.

[0320] [Table 17]

[0321] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0322] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0323] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium alginate is used as a water retention agent.

[0324] Other possible humectants include glycerol, propylene glycol, modified starch, hydroxypropyl cellulose, triacetin, polyethylene glycol (PEG), pectin and xanthan gum.

[0325] Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0326] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0327] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0328] Pouches PPC41 to PPC44 represent different amounts of nicotine usage from 4.8 mg to 12 mg. Pouch PPC45 denotes a pouch that does not contain alginate but otherwise corresponds to pouch PPC43.

[0329] Pouch PPC46 denotes a pouch containing two sugar alcohols. Example 4F - Pouch The pouches PPC51 to PPC53 are manufactured as follows.

[0330] The fiber and powder ingredients (except the nicotine-containing powder and glidant) are mixed for 1 minute using a planetary Bear Varimixer mixer. The NPR and NBT are then added and mixed for 2 minutes (if applicable). The nicotine premix is ​​then added and mixed for 2 minutes. Water is then added and mixed for 5 minutes, followed by the liquid flavor composition (mixed for 1 minute) and glidant (if present) (mixed for 1 minute). The total mixing time is 9-11 minutes.

[0331] [Table 18]

[0332] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, for example, oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bran fiber, bamboo fiber, and cellulose fiber, can be used as well.

[0333] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0334] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0335] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0336] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0337] Pouch PPC51 represents a pouch that uses a nicotine-ion exchange resin premix in combination with nicotine bitartrate (NBT). Pouch PPC52 represents a pouch that uses a nicotine-ion exchange resin premix in combination with nicotine polacrilex resin (NPR).

[0338] Pouch PPC53 represents a pouch that uses a nicotine-ion exchange resin premix in combination with nicotine bitartrate (NBT) and nicotine polacrilex resin (NPR).

[0339] Example 4G-Pouch Pouches PNN1-PNN5, PNN11-PNN15, PNN21-PNN27, PNN31, PPC11-PPC15, PPC21-PPC26, PPC31-PPC37, PPC41-PPC46, and PPC51-PPC53 were also produced in versions combining a mint liquid flavor composition with a mint powdered flavor composition, a lemon liquid flavor composition with a lemon powdered flavor composition further comprising citric acid as a flavor enhancer, and a mint liquid flavor composition with a menthol powdered flavor composition further comprising sodium chloride and ammonium chloride as flavor enhancers.

[0340] Example 4H-Pouch Nicotine premix containing pouches PPC61-PPC67 are prepared containing the powder compositions outlined in Table 16. The pouches are manufactured as follows.

[0341] The fiber and powder ingredients (except for the glidant) are mixed for 2 minutes using a Loedige mixer. The nicotine premix is ​​then added and mixed for 2 minutes. Then, with the mixer running, the water is added and mixed for 15 minutes, followed by the liquid flavors (if present, mixed for 15 minutes) and the glidant (if present, mixed for 1 minute). The total mixing time is 19-35 minutes.

[0342] [Table 19]

[0343] Pouch Contents: 500mg total. Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, such as oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, powdered cellulose, bamboo fiber, bran fiber, and cellulose fiber, can be used as well.

[0344] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0345] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. As humectants, sodium alginate, glycerol and hydroxypropyl cellulose (HPC) may be used, and other humectants described herein may be used in combination with or as an alternative to sodium alginate, glycerol or HPC.

[0346] Sodium carbonate and sodium bicarbonate are used as alkaline buffers, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0347] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0348] Acesulfame potassium and / or sucralose can be used as high-intensity sweeteners, by way of example. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium and / or sucralose or as a substitute for acesulfame potassium and / or sucralose.

[0349] Pouches PPC61-PPC62 demonstrate the use of different sweetener and buffer combinations. Pouches PPC63 to PPC64 represent pouches with different fiber contents. Pouches PPC65 to PPC67 show the use of different humectants.

[0350] Example 4I - Pouch Nicotine premix containing pouches PPC71-PPC76 are prepared containing the powder compositions outlined in Table 17. The pouches are manufactured as follows.

[0351] The fiber and powder ingredients (except for the glidant) are mixed for 2 minutes using a Loedige mixer. The nicotine premix is ​​then added and mixed for 2 minutes. Then, with the mixer running, the water is added and mixed for 15 minutes, followed by the liquid flavors (if present, mixed for 15 minutes) and the glidant (if present, mixed for 1 minute). The total mixing time is 19-35 minutes.

[0352] The final powder composition is filled into pouches (target fill weight pouch: 500 mg powder). The pouch material of Example 1A is used, made from long fiber paper. The powder is filled into the pouch and kept there by sealing. The pouch material of Example 1B can also be used.

[0353] [Table 20-1]

[0354] [Table 20-2]

[0355] Pouch Content: 500mg total, i.e. nicotine concentration of 19.2mg / g. Wheat fiber, trade name "Vitacel® 600 WF Plus".

[0356] Powdered cellulose, trade name "Vitacel® L00" or "Vitacel® L700G". Oat fiber, brand name "Vitacel® 600 WF Plus."

[0357] Pea fiber, trade name "Vitacel(R) EF150". Other fibers that can be used include water-insoluble plant fibers such as oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, bamboo fiber, powdered cellulose, bran fiber, and cellulose fiber.

[0358] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0359] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. As humectants, sodium alginate, glycerol and hydroxypropyl cellulose (HPC) may be used, and other humectants described herein may be used in combination with or as an alternative to sodium alginate, glycerol or HPC.

[0360] Sodium carbonate and sodium bicarbonate are used as alkaline buffers, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0361] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0362] Acesulfame potassium and / or sucralose can be used as high-intensity sweeteners, by way of example. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium and / or sucralose or as a substitute for acesulfame potassium and / or sucralose.

[0363] Pouches PPC71 to PPC74 demonstrate the use of different nicotine premixes. Pouches PPC75 to PPC77 show the use of different fibers. Example 4J-Pouch Pouches PPC81-PPC94 containing nicotine premixes were prepared containing the powder compositions as outlined in Tables 18A and 18B. The pouches are manufactured as follows.

[0364] The fiber and powder ingredients (except for the glidant) are mixed for 2 minutes using a Loedige mixer. The nicotine premix is ​​then added and mixed for 2 minutes. Then, with the mixer running, the water is added and mixed for 15 minutes, followed by the liquid flavors (if present, mixed for 15 minutes) and the glidant (if present, mixed for 1 minute). The total mixing time is 19-35 minutes.

[0365] The final powder composition is filled into pouches (target fill weight pouch: 500 mg powder). The pouch material of Example 1A is used, made from long fiber paper. The powder is filled into the pouch and kept there by sealing. The pouch material of Example 1B can also be used.

[0366] [Table 21]

[0367] [Table 22]

[0368] Nicotine premixes contain water in varying amounts, thereby contributing to the total water content. Pouch Content: 500mg total, i.e. nicotine concentration of 19.2mg / g. Wheat fiber, trade name "Vitacel® 600 WF Plus" or "Vitacel® 200 WF".

[0369] Powdered cellulose, trade name "Vitacel® L00" or "Vitacel® L700G". Oat fiber, brand name "Vitacel® 600 WF Plus."

[0370] Pea fiber, trade name "Vitacel(R) EF150". Other fibers that can be used include water-insoluble plant fibers such as oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, bamboo fiber, powdered cellulose, bran fiber, and cellulose fiber.

[0371] For example, a powdered flavoring composition comprising menthol as a flavoring compound can be used as a powdered flavoring composition, whereas a liquid flavoring composition comprising peppermint as a flavoring compound can be used as a liquid flavoring composition. Of course, other flavorings as described herein can be used in combination with or instead of menthol and / or peppermint as well. The amount of liquid and optionally powdered flavoring composition can be adjusted taking into account the potency of the flavoring applied, the concentration / loading of the flavoring compound, and the desired flavor intensity.

[0372] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. As humectants, sodium alginate, glycerol and hydroxypropyl cellulose (HPC) may be used, and other humectants described herein may be used in combination with or as an alternative to sodium alginate, glycerol or HPC.

[0373] Sodium carbonate and sodium bicarbonate are used as alkaline buffers, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0374] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0375] Acesulfame potassium and / or sucralose can be used as high-intensity sweeteners, by way of example. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium and / or sucralose or as a substitute for acesulfame potassium and / or sucralose.

[0376] Pouches PPC81 to PPC92 show the use of different fibers, different amounts and different nicotine premixes. Pouches PPC93-PPC94 demonstrate the use of buffer pairs and large amounts of salt, respectively.

[0377] Example 4 K-pouch Pouches PPC101-PPC103 containing nicotine premixes were prepared with the powder compositions as outlined in Table 18C. The pouches are manufactured as follows.

[0378] The powdered ingredients, including powdered flavors (if any), are mixed for 2 minutes using a planetary Bear Varimixer mixer. Nicotine is then added and mixed for 2 minutes. Then, with the mixer running, water is slowly added, followed by liquid flavors. Finally, silicon dioxide is added and mixed for approximately 1 minute. Total mixing time is approximately 30 minutes.

[0379] The final powder composition is filled into pouches (target fill weight 500 mg powder per pouch). The pouch material of Example 1A is used, made from long fiber paper. The powder is filled into the pouch and maintained in the pouch by sealing.

[0380] The material of the pouch is a heat-sealable non-woven cellulose, such as a filament paper. Pouches not in the form of a non-woven cellulose fabric can also be used according to the invention. The pouch material of Example 1B can also be used.

[0381] The powder is filled into a pouch and maintained within the pouch by a seal.

[0382] [Table 23]

[0383] Pouch Content: 500mg total, i.e. nicotine concentration of 19.2mg / g. The sugar alcohol may be xylitol (eg, trade name "Xylitab® 200") and / or isomalt (eg, trade name "GalenIQ® 720").

[0384] Wheat fiber, trade name "Vitacel® 600 WF Plus". Other fibers, such as water-insoluble vegetable fibers, such as oat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, bran fiber, bamboo fiber, powdered cellulose, apple fiber, cocoa fiber, and cellulose fiber, can be used as well.

[0385] For example, a mixture of menthol and peppermint can be used. Of course, other flavors described herein can be used in combination with or in place of the menthol and / or peppermint as well.

[0386] As humectants, sodium alginate, glycerol and hydroxypropyl cellulose (HPC) may be used, and other humectants described herein may be used in combination with or as an alternative to sodium alginate, glycerol or HPC.

[0387] Silicon dioxide is used as a glidant. Other possible glidants include magnesium stearate, starch, talc, etc. Sodium carbonate is used as an alkaline buffer, and other buffers described herein may be used in combination with or as a replacement for sodium carbonate.

[0388] Potassium sorbate is used as a preservative, and other preservatives described herein may also be used in combination with or as a substitute for potassium sorbate.

[0389] The high-intensity sweetener may be, for example, acesulfame potassium. Other usable high-intensity sweeteners described herein may be used in combination with acesulfame potassium or as a substitute for acesulfame potassium.

[0390] Pouches PPC101 to PPC101 indicate pouches with different water contents and water-insoluble fiber contents. Example 4 L-Content uniformity measurement Content uniformity (CU) of pouch samples was determined by analysis of 10 replicate subsamples. Nicotine content was measured for each subsample of approximately 500 mg using standard HPLC techniques. Nicotine content of the subsamples was expressed as a percentage of the nominal nicotine content in the sample (i.e., % label claim). For example, if a pouch sample with a nominal nicotine content of 20 mg / g was analyzed to find an actual content of 19 mg / g, the label claim nicotine content would be 95%.

[0391] The content uniformity of the samples is then determined as the relative standard deviation (RSD) of the individual analyses of relative nicotine content in the 10 replicates. Homogeneity was evaluated on two batches of PPC46 produced in different ways: PPC46 was produced according to claim 1, i.e. the liquid flavouring was added after the water, but PPC46 * was similarly prepared by adding a liquid flavoring composition to a powdered composition, and then adding water. * When preparing the liquid flavor composition, the liquid flavor composition is added before the water is added.

[0392] PPC46 * It was visually apparent that PPC46 was significantly less homogeneous than PPC46. This was confirmed by nicotine CU analysis, as can be observed from Table 19 below. Furthermore, PPC46 * The powder composition contained a variety of sized agglomerates and was visually confirmed to be unevenly distributed. The relative standard deviation was measured and the PPC46 * was found to be less homogeneous than PPC46.

[0393] Both pouch compositions were sieved through a 1400 micron sieve and the RSD of nicotine was then measured again. * was found to be less uniform than PPC46.

[0394] [Table 24]

[0395] Example 5 - Evaluation The manufactured pouches of the present invention were evaluated and found to have a very appealing flavor release. This was observed in pouches with and without nicotine.

[0396] Pouched products PPC1 and PNN1 were compared with comparative pouches P1 and P2 (Comp. P1 and P2) with regard to the perception of flavour release. Evaluation of perceived flavor release is performed as described below.

[0397] Perceived flavor release was evaluated by a test panel of four trained judges, each judge evaluating all samples in duplicate. An average rating was estimated. Pouched products PNN1 and PPC1 were rated by all four judges as having a significantly faster onset of flavor release and a more pronounced initial burst of flavor compared to comparisons P1 and P2.

[0398] Pouch product PPC1 was evaluated for the perceived effects of nicotine and for the burning sensation. The perceived effects of nicotine and the burning sensation were assessed as follows:

[0399] The cognitive effects of nicotine and the burning sensation were evaluated by a test panel of four trained judges. Each judge evaluated all samples in duplicate. The average rating was estimated.

[0400] Pouch product PPC1 was rated by all four reviewers as having a fast onset of action and a high nicotine cognitive effect, and pouch product PPC1 was rated by all four reviewers as having a high burning sensation.

[0401] Similarly, the pouch product PPC1 was evaluated for nicotine-induced cognitive effects in the same manner as above. The pouch product PPC1 was rated as having a high nicotine-induced cognitive effect by all four judges.

[0402] Additionally, a burst of flavor was rated as desirable in combination with a burning (tingling) sensation. Example 6 - User evaluation Pouches PNN30 and Comparative P1 were prepared according to Example 2C. Comparative P1 (COMP.P1) was prepared with 8% by weight blackcurrant powdered flavor and no liquid flavor. PNN30 was prepared with 5% by weight blackcurrant powdered flavor and 1.5% by weight blackcurrant liquid flavor.

[0403] The amounts of liquid and optionally powdered flavor compositions were adjusted taking into consideration the potency of the flavor applied, the concentration / loading of the flavor compounds, and the desired flavor intensity. Pouches PPC28 and comparative pouch P2 (COMP.P2) were prepared according to Example 4A.

[0404] The pouches were evaluated by a test panel of four trained judges, with each judge evaluating all samples in duplicate, over a 30 minute period. The test panel evaluated the pouches on four different parameters: moisture sensation, flavor intensity, sweetness intensity, and overall taste.

[0405] [Table 25]

[0406] The test panel found that the pouches containing liquid flavor exhibited higher scores in all parameters during the initial use time, i.e., the first 5 minutes, compared to the pouches not containing liquid flavor.

[0407] PNN30 improved moisturizing sensation during initial use. PNN30 exhibited higher flavor intensity and sweetness intensity both at the initial use time and during the use period, indicating that the pouch promotes not only an initial rapid release of flavor and sweetener, but also a sustained release during use.

[0408] Similarly, overall taste intensity was found to be superior for PNN30 both initially and over the course of use. The above test was repeated with pouch PPC28 and comparative P2 pouch, confirming that the inclusion of liquid flavor resulted in higher flavor intensity. Yet another aspect of the present invention may be as follows. 〔1〕 An oral pouched product comprising: Saliva-permeable pouch and pouch composition Including, The pouch composition comprises: A powder composition; Water, A liquid flavoring composition; Including, The oral pouched product, wherein the liquid flavor composition is added to the powdered composition after the water. 〔2〕 The oral pouched product according to claim 1, wherein the pouch composition further comprises a powdered flavor composition. 〔3〕 The oral pouched product according to [1] or [2], wherein the pouch composition comprises the powdered flavor composition in an amount of at least 1% by weight of the pouch composition, such as at least 3% by weight of the pouch composition, such as at least 5% by weight of the pouch composition. 〔4〕 The oral pouched product according to any one of [1] to [3] above, wherein the pouch composition comprises the powdered flavor composition in an amount of 1 to 20% by weight of the pouch composition, such as at least 3 to 15% by weight of the pouch composition, for example, 5 to 10% by weight of the pouch composition. 〔5〕 The oral pouched product according to any one of [1] to [4], wherein the pouch composition comprises the liquid flavoring composition in an amount of at least 0.01% by weight of the pouch composition, such as at least 0.1% by weight of the pouch composition, such as at least 0.5% by weight of the pouch composition. 〔6〕 The oral pouched product according to any one of [1] to [5] above, wherein the pouch composition contains the liquid flavoring composition in an amount of 0.01 to 10% by weight of the pouch composition, such as 0.1 to 5% by weight of the pouch composition, such as 0.5 to 3% by weight of the pouch composition. 〔7〕 The oral pouched product according to any one of [1] to [6] above, wherein the powdered composition comprises a powdered flavoring composition. 〔8〕 The oral pouched product according to any one of [1] to [7] above, wherein the powdered flavor composition comprises a water-soluble carrier. 〔9〕 The oral pouched product according to any one of [1] to [8] above, wherein the powdered flavor composition contains a flavor compound in an amount of 10 to 95% by weight of the powdered flavor composition. 〔10〕 The oral pouched product according to any one of [1] to [9], wherein the powdered flavoring agent provides flavoring compounds in an amount of 0.1 to 18% by weight of the pouch composition, such as 0.3 to 14% by weight of the pouch composition, for example 0.5 to 9% by weight of the pouch composition. 〔11〕 The oral pouched product according to any one of [1] to

[10] above, wherein the liquid flavoring composition comprises a liquid carrier. 〔12〕 The oral pouched product according to any one of [1] to

[11] above, wherein the liquid flavoring composition contains a flavoring compound in an amount of 10 to 100% by weight of the liquid flavoring composition. 〔13〕 The oral pouched product according to any one of [1] to

[12] above, wherein the liquid flavoring provides a flavoring compound in an amount of 0.01 to 5% by weight of the pouch composition, such as 0.03 to 4% by weight of the pouch composition, such as 0.05 to 3% by weight of the pouch composition. 〔14〕 The oral pouched product according to any one of [1] to

[13] , wherein the liquid flavoring composition comprises at least one of mint, eucalyptus, citrus fruits such as lemon, lime, orange, licorice, raspberry, blackcurrant, or any combination thereof. 〔15〕 The oral pouched product according to any one of [1] to

[14] above, wherein the powdery composition comprises at least one sugar alcohol. 〔16〕 The oral pouched product according to any one of [1] to

[15] , wherein the at least one sugar alcohol is selected from the group consisting of xylitol, maltitol, mannitol, erythritol, isomalt, sorbitol, lactitol, and mixtures thereof. 〔17〕 The oral pouched product according to any one of [1] to

[16] above, wherein the pouch composition comprises at least two sugar alcohols. 〔18〕 The oral pouched product according to any one of [1] to

[17] , wherein the pouch composition comprises the at least one sugar alcohol in an amount of at least 1% by weight of the composition, such as at least 2% by weight of the composition, such as at least 5% by weight of the composition, such as at least 10% by weight of the composition. 〔19〕 The oral pouched product according to any one of [1] to

[18] , wherein the pouch composition comprises the at least one sugar alcohol in an amount of 1 to 80% by weight of the composition, such as 2 to 70% by weight of the composition, such as 5 to 60% by weight of the composition, such as 10 to 50% by weight of the composition. 〔20〕 The oral pouched product according to any one of [1] to

[19] , wherein the at least one sugar alcohol comprises a DC (directly compressible) grade sugar alcohol. 〔21〕 The oral pouched product according to any one of [1] to

[20] above, wherein at least 50% by weight of the at least one sugar alcohol is a DC (directly compressible) grade sugar alcohol. 〔22〕 The oral pouched product according to any one of [1] to

[21] above, wherein the powdery composition contains water-insoluble fiber. 〔23〕 The oral pouched product according to any one of [1] to

[22] above, wherein the powdery composition comprises a sugar alcohol and a water-insoluble fiber. 〔24〕 The oral pouched product according to any one of the above [1] to

[23] , wherein the water-insoluble fiber is a vegetable fiber. 〔25〕 The oral pouched product according to any one of [1] to

[24] , wherein the water-insoluble fiber is selected from wheat fiber, pea fiber, rice fiber, maize fiber, oat fiber, tomato fiber, barley fiber, rye fiber, sugar beet fiber, buckwheat fiber, potato fiber, cellulose fiber, apple fiber, cocoa fiber, cellulose fiber, bran fiber, bamboo fiber, powdered cellulose, and any combination thereof. 〔26〕 The oral pouched product according to any one of [1] to

[25] , wherein the water-insoluble fiber comprises or consists of a water-insoluble fiber selected from wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof. 〔27〕 The oral pouched product according to any one of [1] to

[26] , wherein the water-insoluble fiber has a water binding capacity of at least 200%, such as at least 300%, for example at least 400%. 〔28〕 The oral pouched product according to any one of [1] to

[27] , wherein the water-insoluble composition comprises or consists of water-insoluble fiber in an amount of 5 to 50% by weight of the pouch composition and a water content of 15 to 70% by weight of the pouch composition. 〔29〕 The oral pouched product according to any one of [1] to

[28] , wherein the pouch composition comprises water in an amount of at least 5% by weight of the composition, such as at least 8% by weight of the composition, such as at least 10% by weight of the composition, such as at least 20% by weight of the composition. 〔30〕 The pouch composition comprises water in an amount of less than 65% by weight of the pouch composition, such as less than 60% by weight of the pouch composition, such as less than 50% by weight of the pouch composition, such as less than 40% by weight of the composition. The oral pouched product according to any one of [1] to

[29] above. 〔31〕 The oral pouched product according to any one of [1] to

[30] above, wherein the pouch composition contains water in an amount of 8 to 60% by weight of the composition, such as 8 to 50% by weight of the composition, such as 8 to 40% by weight of the composition, such as 20 to 40% by weight of the composition. 〔32〕 The oral pouched product according to any one of the above [1] to

[31] , wherein the pouch composition contains water in an amount of 20 to 65% by weight of the composition, such as 20 to 60% by weight of the composition, such as 20 to 50% by weight of the composition, such as 20 to 40% by weight of the composition. 〔33〕 The oral pouched product according to any one of [1] to

[32] , wherein the pouch composition contains water and water-insoluble fiber in a weight ratio of 3.0 or less, such as 2.5 or less, such as 2.0 or less, such as 1.5 or less, such as 1.0 or less. 〔34〕 The oral pouched product according to any one of [1] to

[33] , wherein the pouch composition comprises a water-insoluble fiber selected from pea fiber, powdered cellulose, and a combination thereof, and a flavoring composition in an amount of 10% by weight or less of the pouch composition. 〔35〕 The oral pouched product according to any one of [1] to

[34] , wherein the pouch composition further comprises nicotine. 〔36〕 The oral pouched product according to any one of [1] to

[35] , wherein the nicotine is selected from the group consisting of nicotine salts, nicotine free base, nicotine bound to an ion exchanger such as an ion exchange resin such as nicotine polacrilex resin, nicotine inclusion complexes or any non-covalently bound nicotine, nicotine bound to a zeolite, nicotine bound to a cellulose such as microcrystalline cellulose, or starch microspheres, and mixtures thereof. 〔37〕 The oral pouched product according to any one of [1] to [6], wherein the nicotine comprises non-salt nicotine. 〔38〕 The oral pouched product according to any one of [1] to

[37] , wherein the nicotine comprises free base nicotine. 〔39〕 The oral pouched product according to any one of [1] to

[38] , wherein the nicotine comprises nicotine mixed with an ion exchange resin. 〔40〕 The oral pouched product according to any one of the above [1] to

[39] , wherein the nicotine comprises free base nicotine mixed with an ion exchange resin, the weight ratio between the free base nicotine and the ion exchange resin being 0.1 to 2.0, preferably 0.5 to 2.0, and most preferably about 0.67 to 1.0. 〔41〕 The oral pouched product according to any one of [1] to

[40] , wherein the nicotine comprises a nicotine salt. 〔42〕 The oral pouched product according to any one of [1] to

[41] above, wherein the nicotine comprises nicotine bound to an ion exchange resin. 〔43〕 The oral pouched product according to any one of [1] to

[42] , wherein the nicotine comprises synthetic nicotine. 〔44〕 The oral pouched product according to any one of [1] to

[43] above, wherein the nicotine content among a series of at least 10 oral pouches comprising the pouch composition has a relative standard deviation (RSD) of 10% or less, preferably at most 8%, more preferably at most 6%, even more preferably at most 4%, and most preferably at most 2%. 〔45〕 The oral pouched product according to any one of [1] to

[44] , wherein the pouch composition comprises nicotine in an amount of at least 0.1% by weight of the pouch composition, such as at least 0.2% by weight. 〔46〕 The pouched oral product according to any one of [1] to

[45] , wherein the pouch composition contains nicotine in an amount of 0.1 to 5.0% by weight of the pouch composition, such as 0.2 to 4.0% by weight of the pouch composition, for example, 1.0 to 2.0% by weight of the pouch composition. 〔47〕 The oral pouched product according to any one of [1] to

[46] above, wherein the pouch composition does not contain tobacco, tobacco fiber, or fiber derived from tobacco. 〔48〕 The oral pouched product according to any one of [1] to

[47] , wherein the liquid flavoring composition at least partially covers a surface of the powdered composition. 〔49〕 The oral pouched product according to any one of [1] to

[48] , wherein the liquid flavoring composition is at least partially adsorbed onto the surface of the powdered composition. 〔50〕 The pouch composition has a bulk density of at most 0.8 g / cm3, such as at most 0.7 g / cm3, such as at most 0.6 g / cm3, such as at most 0.5 g / cm3. The oral pouched product according to any one of [1] to

[49] above. 〔51〕 The oral pouched product according to any one of the above [1] to

[50] , wherein the pouch composition has a bulk density of 0.2 g / cm3 to 0.8 g / cm3, such as 0.3 g / cm3 to 0.7 g / cm3, such as 0.3 g / cm3 to 0.6 g / cm3, such as 0.4 to 0.5 g / cm3. 〔52〕 The oral pouched product according to any one of [1] to

[51] above, wherein the pouch composition further comprises a pH control agent, such as a basic pH control agent, such as a basic buffering agent. 〔53〕 The oral pouched product according to any one of [1] to

[52] above, wherein the pouch composition comprises an alkaline buffering agent. 〔54〕 The pouch composition comprises the pH control agent in an amount of less than 5% by weight of the pouch composition, for example, less than 4% by weight of the pouch composition, for example, less than 2% by weight of the pouch composition, for example, less than 1% by weight of the pouch composition, or for example, no pH control agent. The oral pouched product according to any one of [1] to

[53] . 〔55〕 The pouch composition is adapted to provide a pH of at least 8.0, such as a pH of at least 8.2, such as a pH of at least 8.5, such as a pH of at least 8.7, such as a pH of at least 9.0, when 2.0 grams of the pouch composition is added to 20 mL of 0.02 M potassium dihydrogen phosphate buffer (pH adjusted to 7.4). The oral pouched product according to any one of [1] to

[54] . 〔56〕 The oral pouched product according to any one of [1] to

[55] , wherein the pH control agent is selected from the group consisting of acetic acid, adipic acid, citric acid, fumaric acid, glucono-δ-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentaposodium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, magnesium oxide, or any combination thereof. 〔57〕 The oral pouched product according to any one of [1] to

[56] , wherein the pH control agent is a basic buffer and / or a basic pH control agent such as sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, or any combination thereof. 〔58〕 The oral pouched product according to any one of [1] to

[57] , wherein the pouch composition comprises a glidant such as silicon dioxide, for example in an amount of 0.5 to 5% by weight of the composition, for example 1 to 3% by weight of the composition. 〔59〕 The oral pouched product according to any one of [1] to

[58] , wherein the composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof, and the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, for example, 10 to 60% by weight of the pouch composition. 〔60〕 the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof; the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, such as 10 to 60% by weight of the pouch composition, and the composition further comprises water-insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; The oral pouched product according to any one of [1] to

[59] above. 〔61〕 the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof; the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, such as 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and The water-insoluble composition comprises or consists of a water-insoluble fiber, such as a water-insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof; The oral pouched product according to any one of [1] to

[60] above. 〔62〕 the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof; the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, such as 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and the water insoluble composition comprises or consists of a water insoluble fiber, such as a water insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof, and the pouch composition comprises a flavoring in an amount of 0.01 to 15% by weight of the pouch composition, such as 0.1 to 15% by weight of the pouch composition, such as 1 to 10% by weight of the pouch composition, such as 3 to 10% by weight of the pouch composition; The oral pouched product according to any one of [1] to

[61] above. 〔63〕 the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof; the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, such as 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and the water insoluble composition comprises or consists of a water insoluble fiber, such as a water insoluble vegetable fiber, such as wheat fiber, oat fiber, pea fiber, powdered cellulose, or a combination thereof, the pouch composition comprises a flavoring in an amount of 0.01-15% by weight of the pouch composition, such as 0.1-15% by weight of the pouch composition, such as 1-10% by weight of the pouch composition, such as 3-10% by weight of the pouch composition, and the flavoring is oil-based; The oral pouched product according to any one of [1] to

[62] above. 〔64〕 the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof; the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, such as 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and the pouch composition comprises a pH control agent selected from the group consisting of acetic acid, adipic acid, citric acid, fumaric acid, glucono-δ-lactone, gluconic acid, lactic acid, malic acid, maleic acid, tartaric acid, succinic acid, propionic acid, ascorbic acid, phosphoric acid, sodium orthophosphate, potassium orthophosphate, calcium orthophosphate, sodium diphosphate, potassium diphosphate, calcium diphosphate, pentasodium triphosphate, pentaposodium triphosphate, sodium polyphosphate, potassium polyphosphate, carbonic acid, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, magnesium carbonate, magnesium oxide, or any combination thereof; The oral pouched product according to any one of [1] to

[63] above. 〔65〕 the pouch composition comprises a sugar alcohol selected from the group consisting of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, hydrogenated starch hydrolysates, isomalt, or any combination thereof; the composition comprises the sugar alcohol in an amount of 1 to 80% by weight of the pouch composition, such as 5 to 70% by weight of the pouch composition, such as 10 to 60% by weight of the pouch composition; the composition further comprises water insoluble fiber in an amount of 5 to 50% by weight of the pouch composition, such as 10 to 30% by weight of the pouch composition; and the pouch composition comprises a basic pH control agent, such as a basic buffer, and / or a pH control agent that is sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, magnesium carbonate, or any combination thereof; The oral pouched product according to any one of [1] to

[64] above. 〔66〕 The oral pouched product according to any one of [1] to

[65] , wherein the membrane of the pouch contains water-insoluble fiber of a different origin from the water-insoluble fiber contained in the pouched product. 〔67〕 The oral pouched product according to any one of [1] to

[66] , wherein the water-insoluble fiber of the film and the water-insoluble fiber of the pouch composition both comprise natural fibers. 〔68〕 The oral pouched product according to any one of [1] to

[67] , wherein the water-insoluble fiber of the film and the water-insoluble fiber of the pouch composition are both natural fibers. 〔69〕 1. An oral pouched product comprising a pouch, a powdered composition and a liquid flavoring composition, said liquid flavoring composition covering at least a portion of a surface of said powdered composition. 〔70〕 The oral pouched product according to any one of

[69] and [1] to

[68] . 〔71〕 1. A method for producing an oral pouched product, the method comprising: Providing a powdered composition; mixing the powdered composition with water; adding a liquid flavor composition to the mixture of water and the powdered composition; adding the resulting mixture to a saliva-permeable pouch; The method includes: 〔72〕 72. The method of claim 71, further comprising the step of sealing the pouch. 〔73〕 The method according to claim 71 or 72, wherein nicotine is added to the mixture of water and the powdered composition before adding the liquid flavoring composition. 〔74〕 The method according to any one of

[71] to

[73] above, wherein a glidant is added after the addition of the liquid flavor composition. 〔75〕 The method according to any one of

[71] to

[74] above for producing the oral pouched product according to any one of [1] to

[70] above. 〔76〕 The oral pouched product according to any one of [1] to

[70] , wherein the water-insoluble fiber has a density of 50 to 500 grams per liter, for example, 100 to 400 grams per liter, for example, 200 to 300 grams per liter.

Claims

1. An oral pouched product comprising: Saliva-permeable pouch and pouch composition Including, The pouch composition comprises: a powdered composition comprising a powdered flavoring composition; Nicotine in an amount of at least 0.1% by weight of the pouch composition; Water, A liquid flavoring composition; Including, The pouch composition is free of tobacco, tobacco fiber, and tobacco-derived fiber; and The oral pouched product, wherein the liquid flavor composition is added to the powdered composition after the water.

2. 10. The oral pouched product of claim 1, wherein said pouch composition comprises said powdered flavor composition in an amount of at least 1% by weight of said pouch composition.

3. 3. The oral pouched product of claim 1 or 2, wherein said pouch composition comprises said liquid flavor composition in an amount of at least 0.01% by weight of said pouch composition.

4. An oral pouched product according to any one of claims 1 to 3, wherein the powdered composition comprises at least one sugar alcohol.

5. 5. The oral pouched product of claim 4, wherein the at least one sugar alcohol is selected from xylitol, maltitol, mannitol, erythritol, isomalt, sorbitol, lactitol, and mixtures thereof.

6. 6. Oral pouched product according to any one of claims 4 to 5, wherein said pouch composition comprises said at least one sugar alcohol in an amount of at least 1% by weight of said pouch composition.

7. 7. Oral pouched product according to any one of claims 1 to 6, wherein the powdered composition comprises water insoluble fibre selected from wheat fibre, pea fibre, rice fibre, maize fibre, oat fibre, tomato fibre, barley fibre, rye fibre, sugar beet fibre, buckwheat fibre, potato fibre, cellulose fibre, apple fibre, cocoa fibre, bran fibre, bamboo fibre, powdered cellulose and any combination thereof.

8. 8. An oral pouched product according to any one of claims 1 to 7, wherein the pouch composition comprises water in an amount of at least 5% by weight of the pouch composition.

9. 9. The oral pouched product of any one of claims 1 to 8, wherein the pouch composition comprises a water insoluble fiber selected from pea fiber, powdered cellulose and combinations thereof, and a flavoring composition in an amount of 10% or less by weight of the pouch composition.

10. 10. The oral pouched product of claim 9, wherein the nicotine is selected from the group consisting of nicotine salts, nicotine free base, nicotine bound to an ion exchanger, nicotine inclusion complexes or any non-covalently bound nicotine, nicotine bound to zeolites, nicotine bound to cellulose or starch microspheres, and mixtures thereof.

11. 11. An oral pouched product according to any one of claims 1 to 10, wherein the pouch composition comprises nicotine in an amount of at least 0.2% by weight of the pouch composition.

12. An oral pouched product according to any one of claims 1 to 11, wherein the liquid flavouring composition is at least partially adsorbed onto the surface of the powdered composition.

13. 13. The oral pouched product of any one of claims 1 to 12, wherein the pouch composition further comprises a pH controlling agent.

14. 1. A method for producing an oral pouched product, the method comprising: Providing a powdered composition comprising a powdered flavoring composition; mixing the powdered composition with water; adding a liquid flavor composition to the mixture of water and the powdered composition; adding the resulting mixture to a saliva-permeable pouch to form a pouch composition; Including, The method of claim 1, wherein the pouch composition is free of tobacco, tobacco fiber, and tobacco-derived fiber, and comprises nicotine.

15. The method of claim 14, further comprising sealing the pouch.

16. 16. The method of claim 14 or 15, wherein the pouch composition comprises the powdered flavor composition in an amount of at least 1% by weight of the pouch composition.

17. The method of any one of claims 14 to 16, wherein the pouch composition comprises the liquid flavorant composition in an amount of at least 0.01% by weight of the pouch composition.

18. The method according to any one of claims 14 to 17, wherein the powdered composition comprises at least one sugar alcohol.

19. 19. The method of claim 18, wherein the at least one sugar alcohol is selected from xylitol, maltitol, mannitol, erythritol, isomalt, sorbitol, lactitol, and mixtures thereof.

20. 20. The method of any one of claims 18 to 19, wherein the pouch composition comprises the at least one sugar alcohol in an amount of at least 1% by weight of the pouch composition.

21. 21. The method of any one of claims 14 to 20, wherein the powdered composition comprises water insoluble fibre selected from wheat fibre, pea fibre, rice fibre, maize fibre, oat fibre, tomato fibre, barley fibre, rye fibre, sugar beet fibre, buckwheat fibre, potato fibre, cellulose fibre, apple fibre, cocoa fibre, bran fibre, bamboo fibre, powdered cellulose and any combination thereof.

22. The method of any one of claims 14 to 21, wherein the pouch composition comprises water in an amount of at least 5% by weight of the pouch composition.

23. 23. The method of any one of claims 14 to 22, wherein the pouch composition comprises a water insoluble fiber selected from pea fiber, powdered cellulose, and combinations thereof, and a flavoring composition in an amount of 10% or less by weight of the pouch composition.

24. 24. The method of any one of claims 14 to 23, wherein the pouch composition comprises nicotine in an amount of at least 0.1% by weight of the pouch composition.

25. 25. The method according to any one of claims 14 to 24, wherein the nicotine is selected from the group consisting of nicotine salts, nicotine free base, nicotine bound to ion exchangers, nicotine inclusion complexes or any non-covalently bound nicotine, nicotine bound to zeolites, nicotine bound to cellulose or starch microspheres, and mixtures thereof.

26. The method according to any one of claims 14 to 25, wherein the liquid flavouring composition is at least partially adsorbed onto the surface of the powdered composition.

27. The method of any one of claims 14 to 26, wherein the pouch composition further comprises a pH control agent.

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