Tricyclic compounds as inhibitors of KRAS

Abstract

Disclosed are compounds of Formula I, methods of using the compounds to inhibit KRAS activity, and pharmaceutical compositions containing such compounds. The compounds are useful for treating, preventing, or ameliorating diseases or disorders associated with KRAS activity, such as cancer. TIFF2023509795000646.tif67154

Description

[Technical Field]

[0001] Related Applications This application claims priority to U.S. Provisional Patent Application No. 62 / 959,536, filed January 10, 2020, and U.S. Provisional Patent Application No. 63 / 052,274, filed July 15, 2020, the contents of each of which are hereby incorporated by reference in their entirety.

[0002] FIELD OF THE INVENTION The present disclosure provides compounds, as well as compositions and methods of use thereof, that modulate KRAS activity and are useful in the treatment of various diseases, including cancer. [Background technology]

[0003] Background of the Invention Ras proteins are part of a family of small GTPases that are activated by growth factors and various extracellular stimuli. The Ras family regulates intracellular signaling pathways that are involved in cell growth, migration, survival, and differentiation. Activation of RAS proteins at the cell membrane leads to the binding of key effectors and the initiation of a cascade of intracellular signaling pathways, including the RAF and PI3K kinase pathways. Somatic mutations in RAS can lead to uncontrolled cell growth and malignant transformation, while RAS protein activation is tightly regulated in normal cells (Simanshu, D. et al., Cell 170.1 (2017): pp. 17-33).

[0004] The Ras family consists of three members: KRAS, NRAS, and HRAS. RAS-mutated cancers account for approximately 25% of human cancers. KRAS is the most commonly mutated isoform, accounting for 85% of all RAS mutations, while NRAS and HRAS mutations are found in 12% and 3% of all RAS-mutated cancers, respectively (Simanshu, D. et al., Cell 170.1 (2017):17-33). KRAS mutations are prevalent in the top three most lethal types of cancer: pancreatic (97%), colorectal (44%), and lung (30%) (Cox, AD et al., Nat Rev Drug Discov (2014) 13:828-51). The majority of RAS mutations occur at amino acid residues 12, 13, and 61. The frequency of specific mutations varies between RAS gene isoforms, with G12 and Q61 mutations prevalent in KRAS and NRAS, respectively, and G12, G13, and Q61 mutations occurring most frequently in HRAS. Furthermore, the spectrum of mutations in RAS isoforms differs between cancer types. For example, KRAS G12D mutations predominate in pancreatic cancer (51%), followed by colorectal adenocarcinoma (45%) and lung cancer (17%), while KRAS G12V mutations are associated with pancreatic cancer (30%), followed by colorectal adenocarcinoma (27%) and lung adenocarcinoma (23%) (Cox, AD et al., Nat Rev Drug Discov (2014) 13: 828-51). In contrast, KRAS G12C mutations predominate in non-small cell lung cancer (NSCLC), accounting for 11-16% of lung adenocarcinomas and 2-5% of pancreatic and colorectal adenocarcinomas (Cox, AD et al., Nat. Rev. Drug Discov. (2014) 13: 828-51). Genomic studies across hundreds of cancer cell lines have demonstrated that cancer cells containing KRAS mutations are highly dependent on KRAS function for cell growth and survival (McDonald, R. et al., Cell 170 (2017): 577-592).The role of mutant KRAS as an oncogenic driver is further supported by extensive in vivo experimental evidence showing that mutant KRAS is required for the development and maintenance of initial tumors in animal models (Cox, AD et al., Nat Rev Drug Discov (2014) 13: 828-51). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] US20090216029 [Patent Document 2] US2017 / 0107216 [Patent Document 3] US2017 / 0145025 [Patent Document 4] US2017 / 0174671 [Patent Document 5] US2017 / 0174679 [Patent Document 6] US2017 / 0320875 [Patent Document 7] US2017 / 0342060 [Patent Document 8] US2017 / 0362253 [Patent Document 9] US2018 / 0016260 [Patent Document 10] WO2002 / 000196 [Non-patent literature]

[0006] [Non-Patent Document 1] Simanshu, D. et al., Cell 170.1 (2017): pp. 17-33 [Non-patent document 2] Cox, AD et al., Nat Rev Drug Discov (2014) 13: pp. 828-51. [Non-patent document 3] McDonald, R. et al., Cell 170 (2017): 577–592

Non-patent document 4

Non-patented document 5

Non-patent document 6

Non-patent document 7

Non-patent document 8

Non-patent document 9

Non-patent document 10

Non-patent document 11

Non-patent document 12

Non-patent document 13

Non-patent document 14

Non-patent document 15

Non-patent document 16

Non-patent document 17

Non-patent document 18

Non-patent document 19

Non-patent document 20

Non-patent document 21

Non-patent document 22

Non-patent document 23

Non-patent document 24

Non-patented document 25

Non-patent document 26

Non-patent document 27

Non-patent document 28

Non-patent document 29

Non-patent document 30

Non-patent document 31

Non-patent document 32

Non-patent document 33

Non-patent document 34

Non-patented document 35

Non-patent document 36

Non-patent document 37

Non-patent document 38

Non-patent document 39

Non-patent document 40

[0007] Taken together, these findings suggest that KRAS mutations play an important role in human cancer; therefore, the development of inhibitors targeting mutant KRAS may be useful in the clinical treatment of diseases characterized by KRAS mutations. [Means for solving the problem]

[0008] The present disclosure relates, inter alia, to compounds of formula I:

[0009] [ka]

[0010] or a pharmaceutically acceptable salt thereof, wherein the constituent variables are defined herein.

[0011] The present disclosure further provides a pharmaceutical composition comprising a compound of the present disclosure or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.

[0012] The present disclosure further provides a method for inhibiting KRAS activity, comprising administering to an individual a compound of the present disclosure or a pharmaceutically acceptable salt thereof.The present disclosure also provides the use of the compounds described herein in the manufacture of a medicament for use in a therapeutic method.The present disclosure also provides the compounds described herein for use in a therapeutic method.

[0013] The present disclosure further provides a method of treating a disease or disorder in a patient, the method comprising administering to the patient a therapeutically effective amount of a compound of the present disclosure, or a pharmaceutically acceptable salt thereof. DETAILED DESCRIPTION OF THE INVENTION

[0014] Detailed Description compound In one aspect, the present disclosure provides a compound of formula I:

[0015] [ka]

[0016] or a pharmaceutically acceptable salt thereof (In the formula, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, CN, OR a1 , S.R. a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 ,OC(O)R b1 , OC(O)NR c1 R d1 , N.R. c1 R d1 , N.R. c1 C(O)R b1 , N.R. c1 C(O)OR a1 , N.R. c1 C(O)NR c1 R d1 , N.R. c1 S(O)R b1 , N.R. c1 S(O)2R b1 , N.R. c1 S(O)NR c1 R d1 , S(O)R b1 , S(O)NR c1 R d1 , S(O)2R b1 , S(O)NR c1 R d1 and BR h1 R i1 wherein C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 2 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a2 , S.R. a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 ,OC(O)R b2 , OC(O)NR c2 R d2 , N.R. c2 R d2 , N.R. c2 C(O)R b2 , N.R. c2 C(O)OR a2 , N.R. c2 C(O)NR c2 R d2 , C(=NR e2 )R b2 , C(=NOR a2 )R b2 , C(=NR e2 )NR c2 R d2 , N.R. c2 C(=NR e2 )NR c2 R d2 , N.R. c2 C(=NR e2 )R b2 , N.R. c2 S(O)R b2 , N.R. c2 S(O)2R b2 , N.R. c2 S(O)NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O)2Rb2 , S(O)NR c2 R d2 , and B.R. h2 R i2 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is selected from =O and =S; R 3 is H, C 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 alkylene; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , C(=NR e3 )R b3 , C(=NOR a3 )R b3 , C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )R b3 , N.R. c3 S(O)R b3 , N.R. c3 S(O)2R b3 , N.R. c3 S(O)NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O)2R b3 , S(O)NR c3 R d3 , and B.R. h3 R i3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R 5 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 alkylene; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a6 , S.R. a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , C(=NR e6 )R b6 , C(=NOR a6 )R b6 , C(=NR e6 )NR c6 R d6 , N.R. c6 C(=NR e6 )NRc6 R d6 , N.R. c6 C(=NR e6 )R b6 , N.R. c6 S(O)R b6 , N.R. c6 S(O)2R b6 , N.R. c6 S(O)NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O)2R b6 , S(O)NR c6 R d6 , and B.R. h6 R i6 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C1~3 Alkylene, Halo, D, CN, NO2, OR a7 , S.R. a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7 , C(=NR e7 )R b7 , C(=NOR a7 )R b7 , C(=NR e7 )NR c7 R d7 , N.R. c7 C(=NR e7 )NR c7 R d7 , N.R. c7 C(=NR e7 )R b7 , N.R. c7 S(O)R b7 , N.R. c7 S(O)2R b7 , N.R. c7 S(O)NR c7 R d7 , S(O)R b7 , S(O)NR c7 R d7 , S(O)2R b7 , S(O)NR c7 R d7 , and B.R. h7 R i7 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is C 3~10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 aryl and 5-10 membered heteroaryl; the 4-14 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-14 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a10 , S.R. a10 , C(O)R b10 , C(O)NR c10R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 , N.R. c10 C(O)NR c10 R d10 , C(=NR e10 )R b10 , C(=NOR a10 )R b10 , C(=NR e10 )NR c10 R d10 , N.R. c10 C(=NR e10 )NR c10 R d10 , N.R. c10 S(O)R b10 , N.R. c10 S(O)2R b10 , N.R. c10 S(O)NR c10 R d10 , S(O)R b10 , S(O)NR c10 R d10 , S(O)2R b10 , S(O)NR c10 R d10 , and B.R. h10 R i10 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 11and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 11 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a11 , S.R. a11 , C(O)R b11 , C(O)NR c11 R d11 , C(O)OR a11 ,OC(O)R b11 , OC(O)NR c11 R d11 , N.R. c11 R d11 , N.R. c11 C(O)R b11 , N.R. c11 C(O)OR a11 , N.R. c11 C(O)NR c11 R d11 , N.R. c11 S(O)R b11 , N.R. c11 S(O)2R b11 , N.R. c11 S(O)NR c11 R d11 , S(O)R b11 , S(O)NR c11 R d11 , S(O)2R b11 , S(O)NR c11 R d11 and BR h11 R i11 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 12 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 12 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a12 , S.R. a12 , C(O)R b12 , C(O)NR c12 R d12 , C(O)OR a12 ,OC(O)R b12 , OC(O)NR c12 R d12 , N.R. c12 R d12 , N.R. c12 C(O)R b12 , N.R. c12 C(O)OR a12 , N.R. c12 C(O)NR c12 R d12 , N.R. c12 S(O)R b12 , N.R. c12 S(O)2R b12 , N.R. c12 S(O)NR c12 R d12 , S(O)R b12 , S(O)NR c12 R d12 , S(O)2R b12 , S(O)NR c12 Rd12 and BR h12 R i12 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a20 , S.R. a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , N.R. c20 C(O)NR c20 R d20 , C(=NR e20 )R b20 , C(=NOR a20 )R b20 , C(=NR e20 )NR c20 R d20 , N.R.c20 C(=NR e20 )NR c20 R d20 , N.R. c20 S(O)R b20 , N.R. c20 S(O)2R b20 , N.R. c20 S(O)NR c20 R d20 , S(O)R b20 , S(O)NR c20 R d20 , S(O)2R b20 , S(O)NR c20 R d20 , and B.R. h20 R i20 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3Alkylene, Halo, D, CN, OR a21 , S.R. a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , N.R. c21 C(O)NR c21 R d21 , N.R. c21 S(O)R b21 , N.R. c21 S(O)2R b21 , N.R. c21 S(O)NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 , S(O)2R b21 , S(O)NR c21 R d21 and BR h21 R i21 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 22 is C 1~6 Alkyl, C 2~6 Alkenyl, C2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a22 , S.R. a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , N.R. c22 R d22 , N.R. c22 C(O)R b22 , N.R. c22 C(O)OR a22 , N.R. c22 C(O)NR c22 R d22 , N.R. c22 S(O)R b22 , N.R. c22 S(O)2R b22 , N.R. c22 S(O)NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 , S(O)2R b22 , S(O)NR c22 R d22 and BR h22 R i22 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 23 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 23 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a23 , S.R. a23 , C(O)R b23 , C(O)NR c23 R d23 , C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , N.R. c23 R d23 , N.R. c23 C(O)R b23 , N.R. c23 C(O)OR a23 , N.R. c23 C(O)NR c23 R d23 , N.R. c23 S(O)R b23 , N.R. c23 S(O)2R b23 , N.R. c23 S(O)NR c23 R d23 , S(O)R b23 , S(O)NR c23R d23 , S(O)2R b23 , S(O)NR c23 R d23 and BR h23 R i23 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 24 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 24 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a24 , S.R. a24 , C(O)R b24 , C(O)NR c24 R d24 , C(O)OR a24 ,OC(O)R b24 , OC(O)NR c24 R d24 , N.R. c24 R d24 , N.R. c24 C(O)R b24 , N.R. c24 C(O)OR a24 , N.R. c24 C(O)NR c24 R d24 , N.R. c24 S(O)R b24 , N.R. c24 S(O)2R b24, N.R. c24 S(O)NR c24 R d24 , S(O)R b24 , S(O)NR c24 R d24 , S(O)2R b24 , S(O)NR c24 R d24 and BR h24 R i24 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a30 , S.R. a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , N.R. c30 C(O)NRc30 R d30 , N.R. c30 S(O)R b30 , N.R. c30 S(O)2R b30 , N.R. c30 S(O)NR c30 R d30 , S(O)R b30 , S(O)NR c30 R d30 , S(O)2R b30 , S(O)NR c30 R d30 and BR h30 R i30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a31 , S.R.a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , N.R. c31 S(O)R b31 , N.R. c31 S(O)2R b31 , N.R. c31 S(O)NR c31 R d31 , S(O)R b31 , S(O)NR c31 R d31 , S(O)2R b31 , S(O)NR c31 R d31 and BR h31 R i31 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 32 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 , S.R. a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32 C(O)OR a32 , N.R. c32 C(O)NR c32 R d32 , N.R. c32 S(O)R b32 , N.R. c32 S(O)2R b32 , N.R. c32 S(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 and BR h32 R i32 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 50 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a50 , S.R. a50 , C(O)R b50 , C(O)NR c50 R d50 , C(O)OR a50 ,OC(O)R b50 , OC(O)NR c50 R d50 , N.R. c50 R d50 , N.R. c50 C(O)R b50 , N.R. c50 C(O)OR a50 , N.R. c50 C(O)NR c50 R d50 , N.R. c50 S(O)R b50 , N.R. c50 S(O)2R b50 , N.R. c50 S(O)NR c50 R d50 , S(O)R b50 , S(O)NR c50 R d50 , S(O)2R b50 , S(O)NR c50 R d50 and BR h50 R i50 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 , S.R. a51 , C(O)R b51 , C(O)NR c51 R d51 , C(O)OR a51 ,OC(O)R b51 , OC(O)NR c51 R d51 , N.R. c51 R d51 , N.R. c51 C(O)R b51 , N.R. c51 C(O)OR a51 , N.R. c51 C(O)NR c51 R d51 , N.R. c51 S(O)R b51 , N.R. c51 S(O)2R b51 , N.R. c51 S(O)NR c51 R d51 , S(O)R b51 , S(O)NR c51 R d51 , S(O)2R b51 , S(O)NR c51 R d51 and BR h51 R i51 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, C 6~10 Aryl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R52 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 52 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a52 , S.R. a52 , C(O)R b52 , C(O)NR c52 R d52 , C(O)OR a52 ,OC(O)R b52 , OC(O)NR c52 R d52 , N.R. c52 R d52 , N.R. c52 C(O)R b52 , N.R. c52 C(O)OR a52 , N.R. c52 C(O)NR c52 R d52 , N.R. c52 S(O)R b52 , N.R. c52 S(O)2R b52 , N.R. c52 S(O)NR c52 R d52 , S(O)R b52 , S(O)NR c52 R d52 , S(O)2R b52 , S(O)NR c52 R d52 and BR h52 R i52 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 60 is C1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a60 , S.R. a60 , C(O)R b60 , C(O)NR c60 R d60 , C(O)OR a60 ,OC(O)R b60 , OC(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , N.R. c60 C(O)OR a60 , N.R. c60 C(O)NR c60 R d60 , N.R. c60 S(O)R b60 , N.R. c60 S(O)2R b60 , N.R. c60 S(O)NR c60 R d60 , S(O)R b60 , S(O)NR c60 R d60 , S(O)2R b60 , S(O)NR c60 R d60 and BR h60 R i60 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 61 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a61 , S.R. a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 ,OC(O)R b61 , OC(O)NR c61 R d61 , N.R. c61 R d61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)R b61 , N.R. c61 S(O)2R b61 , N.R. c61 S(O)NR c61 R d61 , S(O)Rb61 , S(O)NR c61 R d61 , S(O)2R b61 , S(O)NR c61 R d61 and BR h61 R i61 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 62 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 62 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a62 , S.R. a62 , C(O)R b62 , C(O)NR c62 R d62 , C(O)OR a62 ,OC(O)R b62 , OC(O)NR c62 R d62 , N.R. c62 R d62 , N.R. c62 C(O)R b62 , N.R. c62 C(O)OR a62 , N.R. c62 C(O)NR c62 R d62 , N.R. c62 S(O)R b62 , N.R.c62 S(O)2R b62 , N.R. c62 S(O)NR c62 R d62 , S(O)R b62 , S(O)NR c62 R d62 , S(O)2R b62 , S(O)NR c62 R d62 and BR h62 R i62 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 70 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a70 , S.R. a70 , C(O)R b70 , C(O)NR c70 R d70 , C(O)OR a70 ,OC(O)R b70 , OC(O)NR c70 R d70 , N.R. c70 R d70 , N.R. c70 C(O)R b70 , N.R. c70 C(O)ORa70 , N.R. c70 C(O)NR c70 R d70 , N.R. c70 S(O)R b70 , N.R. c70 S(O)2R b70 , N.R. c70 S(O)NR c70 R d70 , S(O)R b70 , S(O)NR c70 R d70 , S(O)2R b70 , S(O)NR c70 R d70 and BR h70 R i70 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 71 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 71 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3Alkylene, Halo, D, CN, OR a71 , S.R. a71 , C(O)R b71 , C(O)NR c71 R d71 , C(O)OR a71 ,OC(O)R b71 , OC(O)NR c71 R d71 , N.R. c71 R d71 , N.R. c71 C(O)R b71 , N.R. c71 C(O)OR a71 , N.R. c71 C(O)NR c71 R d71 , N.R. c71 S(O)R b71 , N.R. c71 S(O)2R b71 , N.R. c71 S(O)NR c71 R d71 , S(O)R b71 , S(O)NR c71 R d71 , S(O)2R b71 , S(O)NR c71 R d71 and BR h71 R i71 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 72 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 72 is C 1~6 Alkyl, C 2~6 Alkenyl, C2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a72 , S.R. a72 , C(O)R b72 , C(O)NR c72 R d72 , C(O)OR a72 ,OC(O)R b72 , OC(O)NR c72 R d72 , N.R. c72 R d72 , N.R. c72 C(O)R b72 , N.R. c72 C(O)OR a72 , N.R. c72 C(O)NR c72 R d72 , N.R. c72 S(O)R b72 , N.R. c72 S(O)2R b72 , N.R. c72 S(O)NR c72 R d72 , S(O)R b72 , S(O)NR c72 R d72 , S(O)2R b72 , S(O)NR c72 R d72 and BR h72 R i72 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a1 , R b1 , R c1 and R d1 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c1 and R d1 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h1 and R i1 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h1 and R i1 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a2 , R b2 , R c2 and R d2 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached, R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e2 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h2 and R i2 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h2 and R i2 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a3 , R b3 , R c3 and Rd3 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e3 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h3 and R i3 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atomh3 and R i3 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; Each R j3 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R j3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R b6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached, R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: Each R e6 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h6 and R i6 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h6 and R i6 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a7 , R b7 , R c7 and R d7 are H and C, respectively. 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c7 and R d7 together with the N atom to which they are attached, R 70 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e7 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h7 and R i7 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h7 and R i7together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c10 and R d10 together with the N atom to which they are attached, R 11 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e10 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h10 and R i10 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h10 and R i10 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a11 , R b11 , R c11 and R d11 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 12 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c11 and R d11 together with the N atom to which they are attached, R 12 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h11 and R i11 are OH and C, respectively. 1~6 Alkoxy and C 1~6haloalkoxy; or any R bonded to the same B atom h11 and R i11 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a12 , R b12 , R c12 and R d12 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h12 and R i12 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h12 and R i12 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl;1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c20 and R d20 together with the N atom to which they are attached, R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e20 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h20 and R i20 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h20 and R i20 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a21 , Rb21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c21 and R d21 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h21 and R i21 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h21 and R i21 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a22 , R b22 , R c22 and R d22 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 23 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c22 and R d22 together with the N atom to which they are attached, R 23 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h22 and R i22 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h22 and R i22 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a23 , R b23 , R c23 and R d23 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 24 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c23 and R d23 together with the N atom to which they are attached, R 24 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h23 and R i23 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h23 and R i23 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a24 , R b24 , R c24 and R d24 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h24 and R i24 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h24 and R i24 together with the B atoms to which they are bonded,1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h30 and R i30 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h30 and R i30 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a31 , R b31, R c31 and R d31 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached, R 32 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h31 and R i31 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h31 and R i31 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a32 , R b32 , R c32 and R d32 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c32 and R d32 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h32 and R i32 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h32 and R i32 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a50 , R b50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c50 and Rd50 together with the N atom to which they are attached, R 51 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h50 and R i50 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h50 and R i50 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a51 , R b51 , R c51 and R d51 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 52 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c51 and R d51 together with the N atom to which they are attached, R 52 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h51 and R i51 are OH and C, respectively.1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h51 and R i51 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a52 , R b52 , R c52 and R d52 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c52 and R d52 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h52 and R i52 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h52 and R i52 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a60 , R b60 , R c60and R d60 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c60 and R d60 together with the N atom to which they are attached, R 61 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h60 and R i60 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h60 and R i60 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a61 , R b61 , R c61 and R d61 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 62 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c61 and R d61 together with the N atom to which they are attached, R 62 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h61 and R i61 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h61 and R i61 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a62 , R b62 , R c62 and R d62 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c62 and Rd62 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h62 and R i62 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h62 and R i62 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a70 , R b70 , R c70 and R d70 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 71 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c70 and R d70 together with the N atom to which they are attached, R 71 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Rh70 and R i70 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h70 and R i70 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a71 , R b71 , R c71 and R d71 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 72 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c71 and R d71 together with the N atom to which they are attached, R 72 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h71 and R i71 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h71 and R i71 together with the B atoms to which they are bonded,1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a72 , R b72 , R c72 and R d72 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c72 and R d72 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h72 and R i72 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h72 and R i72 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; Each R g D, OH, NO2, CN, halo, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, C 3~6 Cycloalkyl-C 1~2Alkylene, C 1~6 Alkoxy, C 1~6 Haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, Cyano-C 1~3 Alkyl, H2N-C 1~3 Alkyl, Amino, C 1~6 Alkylamino, di(C 1~6 Alkyl)amino, thio, C 1~6 Alkylthio, C 1~6 Alkylsulfinyl, C 1~6 Alkyl sulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl) carbamyl, carboxy, C 1~6 Alkyl carbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 Alkylcarbonyloxy, aminocarbonyloxy, C 1~6 Alkylaminocarbonyloxy, di(C 1~6 alkyl)aminocarbonyloxy, C 1~6 Alkyl sulfonyl amino, amino sulfonyl, C 1~6 Alkylaminosulfonyl, di(C 1~6 Alkyl)aminosulfonyl, aminosulfonylamino, C 1~6 Alkylaminosulfonylamino, di(C 1~6 Alkyl)aminosulfonylamino, aminocarbonylamino, C 1~6 Alkylaminocarbonylamino, di(C 1~6 alkyl)aminocarbonylamino; However, Cy 1 is other than 3,5-dimethylisoxazol-4-yl, 3,5-dimethyl-1H-pyrazol-4-yl or 4-(1-oxo-2-propen-1-yl)phenyl).

[0017] In one embodiment, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 H, D, C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, CN, OR a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 ,OC(O)R b1 , OC(O)NR c1 R d1 , N.R. c1 R d1 , N.R. c1 C(O)R b1 , N.R. c1 C(O)OR a1 , S(O)2R b1 and S(O)NR c1 R d1 C is selected from 1~6 Alkyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 2 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a2 , S.R. a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)OR a2 ,OC(O)R b2 , OC(O)NR c2 R d2 , N.R. c2 R d2 , N.R. c2 C(O)R b2 , N.R. c2 C(O)OR a2, N.R. c2 C(O)NR c2 R d2 , N.R. c2 S(O)2R b2 , N.R. c2 S(O)NR c2 R d2 , S(O)2R b2 and S(O)NR c2 R d2 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl;1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , N.R. c3 S(O)2R b3 , N.R. c3 S(O)NR c3 R d3 , S(O)2R b3 and S(O)NRc3 R d3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 cycloalkyl, and 4- to 10-membered heterocycloalkyl; 1~6 Alkyl, C 3~10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , S(O)2R b6 and S(O)NR c6 R d6 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is H, C 1~6 Alkyl, C1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a7 , S.R. a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7 , N.R. c7 S(O)2R b7 , N.R. c7 S(O)NR c7 R d7 , S(O)2R b7 and S(O)NR c7 R d7 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is selected from 4-14 membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of a 4-14 membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; and a 4-14 membered heterocycloalkyl is selected from R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR a10 , S.R. a10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 , N.R. c10 C(O)NR c10 R d10 , N.R. c10 S(O)2R b10 , N.R. c10 S(O)NR c10 R d10 , S(O)2R b10 and S(O)NR c10 R d10 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 11 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a11 , C(O)R b11 , C(O)NR c11 R d11 , C(O)OR a11 ,OC(O)R b11 , OC(O)NR c11 R d11 , N.R. c11 R d11 , N.R. c11 C(O)R b11 , N.R.c11 C(O)OR a11 , S(O)2R b11 and S(O)NR c11 R d11 are independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR a20 , S.R. a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , N.R. c20 C(O)NR c20 R d20 , N.R. c20 S(O)2R b20 , N.R. c20 S(O)NR c20 R d20 , S(O)2R b20 and S(O)NR c20 R d20 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a21, C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , S(O)2R b21 and S(O)NR c21 R d21 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 22 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , N.R. c22 R d22 , N.R. c22 C(O)R b22 , N.R. c22 C(O)OR a22 , S(O)2R b22 and S(O)NR c22 R d22 are independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a30 , S.R. a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , S(O)2R b30 and S(O)NR c30 R d30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl and 4-10 membered heterocycloalkyl, halo, D, CN, OR a31 , C(O)Rb31 , C(O)NR c31 R d31 , C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , S(O)2R b31 and S(O)NR c31 R d31 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 32 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32 C(O)OR a32 , S(O)2R b32 and S(O)NR c32 R d32 are independently selected from; Each R 50 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 , C(O)Rb50 , C(O)NR c50 R d50 , C(O)OR a50 ,OC(O)R b50 , OC(O)NR c50 R d50 , N.R. c50 R d50 , N.R. c50 C(O)R b50 , N.R. c50 C(O)OR a50 , S(O)2R b50 and S(O)NR c50 R d50 wherein C is independently selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a51 , C(O)R b51 , C(O)NR c51 R d51 , C(O)OR a51 ,OC(O)R b51 , OC(O)NR c51 R d51 , N.R. c51 R d51 , N.R. c51 C(O)R b51 , N.R. c51 C(O)OR a51 , S(O)2R b51 and S(O)NR c51 R d51 wherein C is independently selected from 1~6 Each alkyl is R 52 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 52 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a52 , C(O)Rb52 , C(O)NR c52 R d52 , C(O)OR a52 ,OC(O)R b52 , OC(O)NR c52 R d52 , N.R. c52 R d52 , N.R. c52 C(O)R b52 , N.R. c52 C(O)OR a52 , S(O)2R b52 and S(O)NR c52 R d52 are independently selected from; Each R 60 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , S.R. a60 , C(O)R b60 , C(O)NR c60 R d60 , C(O)OR a60 ,OC(O)R b60 , OC(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , N.R. c60 C(O)OR a60 , S(O)2R b60 and S(O)NR c60 R d60 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 61 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 ,OC(O)R b61 , OC(O)NR c61 R d61 , N.R. c61 R d61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , S(O)2R b61 and S(O)NR c61 R d61 are independently selected from; Each R 70 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a70 , C(O)R b70 , C(O)NR c70 R d70 , C(O)OR a70 ,OC(O)R b70 , OC(O)NR c70 R d70 , N.R. c70 R d70 , N.R. c70 C(O)R b70 , N.R. c70 C(O)OR a70 , S(O)2R b70 and S(O)NR c70 R d70 are independently selected from; R a1 , R b1 , R c1 and R d1 are H and C, respectively. 1~6 Alkyl, C 1~6 haloalkyl; 1~6 Each alkyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a2 , Rb2 , R c2 and R d2 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached, R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R j3 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R j3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R b6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached, R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a7 , R b7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl and C 1~6 haloalkyl; 1~6 Each alkyl is R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 independently selected from cycloalkyl and 4- to 10-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c10 and R d10 together with the N atom to which they are attached, R 11 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a11 , R b11 , R c11 and Rd11 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 independently selected from cycloalkyl and 4- to 10-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c20 and R d20 together with the N atom to which they are attached, R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R b21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a22 , R b22 , R c22 and R d22 are H and C, respectively. 1~6 Alkyl and C 1~6independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R b31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 7-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached, R 32 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a32 , R b32 , R c32 and R d32 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a50 , R b50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c50 and R d50 together with the N atom to which they are attached, R 51 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a51 , R b51 , R c51 and R d51 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 52 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a52 , R b52 , R c52 and R d52 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a60 , R b60 , R c60 and R d60 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c60 and R d60 together with the N atom to which they are attached, R 61 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a61 , R b61 , R c61 and R d61 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a70 , R b70 , R c70 and R d70 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; Each R g D, OH, CN, halo, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, C 3~6 Cycloalkyl-C 1~2 Alkylene, C 1~6 Alkoxy, C 1~6 Haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, Cyano-C 1~3 Alkyl, H2N-C 1~3 Alkyl, Amino, C 1~6 Alkylamino, di(C 1~6 Alkyl)amino, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl) carbamyl, carboxy, C 1~6 Alkyl carbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 Alkylcarbonyloxy and di(C 1~6 alkyl)aminosulfonyl.

[0018] In another embodiment, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN; R 2 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a2 and NR c2 R d2 Selected from; Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each independently have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 and S(O)2R b3 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R5 is H, C 1~6 Alkyl and C 1~6 haloalkyl; 1~6 Each alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 and S(O)2R b6 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, ORa7 and NR c7 R d7 Selected from; Cy 2 are selected from 4-10 membered heterocycloalkyl, each independently having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; a ring-forming carbon atom of a 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; a 4-10 membered heterocycloalkyl is selected from R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 and S(O)2R b10 are independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20C(O)OR a20 and S(O)2R b20 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a21 and NR c21 R d21 are independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 and S(O)2R b30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a31 and NR c31 R d31 are independently selected from; Each R 50 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 and NR c50 R d50 wherein C is independently selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a51 and NR c51 R d51 are independently selected from; Each R 60 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , C(O)R b60 , C(O)NR c60 R d60 , C(O)OR a60 ,OC(O)R b60 , OC(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , N.R. c60 C(O)OR a60 and S(O)2R b60are independently selected from; R a2 , R c2 and R d2 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5-10 membered heteroaryl; or any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R j3 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R j3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R b6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached, R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a10 , R b10 , R c10 and R d10 are H and C, respectively.1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c50 and R d50 together with the N atom to which they are attached, R 51 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a51 , R c51 and R d51 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; R a60 , R b60 , R c60 and R d60 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5-10 membered heteroaryl; or any R bonded to the same N atom c60 and R d60 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group.

[0019] In yet another embodiment, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 H, D, C 1~3 Alkyl, C 1~3 selected from haloalkyl, halo, and CN; R 2 is H, C 1~3 Alkyl, C 1~3 selected from haloalkyl, phenyl, 5-6 membered heteroaryl, halo, D and CN; Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, or 3 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is H, C 1~3 Alkyl, C 1~3 haloalkyl, phenyl, and 5- to 6-membered heteroaryl; 1~3 Alkyl, phenyl and 5-6 membered heteroaryl are each R 30 and optionally substituted with 1 or 2 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, halo, D, CN, OR a3 and NR c3 R j3 C is selected from 1~3 Alkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, C 6~10 Aryl and 5- to 6-membered heteroaryl are each R 30 and optionally substituted with 1 or 2 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H, C 1~3 Alkyl and C 1~3 haloalkyl;1~3 Alkyl is R 50 and optionally substituted with 1 or 2 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, OR a6 and NR c6 R d6 C is selected from 1~3 Alkyl, C 3~6 Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl are each R 60 and optionally substituted with 1 or 2 substituents independently selected from: R 7 is H, C 1~3 Alkyl, C 1~3 selected from haloalkyl, halo, D and CN; Cy 2 is selected from 4- to 6-membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; a ring-forming carbon atom of a 4- to 6-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; and a 4- to 6-membered heterocycloalkyl is selected from R 20 and optionally substituted with 1 or 2 substituents independently selected from: Each R 10 is C 1~3 Alkyl, C 1~3 Haloalkyl, Halo, D, CN, OR a10 and NRc10 R d10 are independently selected from; Each R 20 is C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl, C 1~3 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 and NR c20 R d20 wherein C is independently selected from 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Each alkynyl is R 21 and optionally substituted with 1 or 2 substituents independently selected from: Each R 21 is C 1~3 Alkyl, C 1~3 independently selected from haloalkyl, halo, D, and CN; Each R 30 is C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 and NR c30 R d30 wherein C is independently selected from 1~3 Alkyl, C 3~6 Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl are each R 31 and optionally substituted with 1 or 2 substituents independently selected from: Each R 31 is C 1~3 Alkyl, C 1~3 independently selected from haloalkyl, halo, D and CN; Each R 50 is C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6independently selected from cycloalkyl, 4- to 6-membered heterocycloalkyl, halo, D, and CN; 1~3 Alkyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 51 and optionally substituted with 1 or 2 substituents independently selected from: Each R 51 is C 1~3 Alkyl, C 1~3 independently selected from haloalkyl, halo, D and CN; Each R 60 is C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a60 and NR 60 R d60 are independently selected from; R a3 and R c3 are H and C, respectively. 1~3 Alkyl and C 1~3 haloalkyl; 1~3 Alkyl is R 30 and optionally substituted with 1 or 2 substituents independently selected from: Each R j3 is C 1~3 Alkyl, and C 1~3 haloalkyl; 1~3 Alkyl is R 30 and optionally substituted with 1 or 2 substituents independently selected from: R a6 , R c6 and R d6 are H and C, respectively. 1~3 Alkyl and C 1~3 haloalkyl; 1~3 Alkyl is R 60 and optionally substituted with 1 or 2 substituents independently selected from: R a10 , R b10 , R c10 and R d10are H and C, respectively. 1~3 Alkyl and C 1~3 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl and C 1~3 haloalkyl; 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Each alkynyl is R 21 and optionally substituted with 1 or 2 substituents independently selected from: R a30 , R c30 and R d30 are H and C, respectively. 1~3 Alkyl and C 1~3 haloalkyl; 1~3 Each alkyl is R 31 and optionally substituted with 1 or 2 substituents independently selected from: R a60 , R c60 and R d60 are H and C, respectively. 1~3 Alkyl and C 1~3 haloalkyl.

[0020] In yet another embodiment, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 is H, C 1~6 selected from alkyl, 5-10 membered heteroaryl, halo, and CN; Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10aryl and 6- to 10-membered heteroaryl; 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is C 1~6 Alkyl, C 6~10 aryl and 5-10 membered heteroaryl; 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl and OR a3 C is selected from 1~6 Alkyl, 4-10 membered heterocycloalkyl and C 6~10 Each aryl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H and C 1~6 alkyl; 1~6 Alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~6 alkyl, 4- to 10-membered heterocycloalkyl, and 5- to 10-membered heteroaryl; 1~6 Alkyl, 4- to 10-membered heterocycloalkyl, and 5- to 10-membered heteroaryl are each R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is a halo; Cy 2 is selected from 4-10 membered heterocycloalkyl; R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, halo, CN and OR a10 are independently selected from; Each R 20 is C 1~6 Alkyl, CN, OR a20 , C(O)R b20 and C(O)NR c20 R d20 wherein C is independently selected from 1~6 Alkyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is CN; Each R 30 is C 1~6 Alkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, OR a30 and NR c30 R d30 wherein C is independently selected from 1~6 Alkyl, 4- to 10-membered heterocycloalkyl, and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 is alkyl; Each R 50 is a 4- to 10-membered heterocycloalkyl; R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6 is alkyl; Each R 60 is C 1~6 Alkyl, 4-10 membered heterocycloalkyl, OR a60 and NR c60 R d60 are independently selected from; Each R a3 is C 1~6 alkyl, and R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R a10 H, and C 1~6 independently selected from alkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl and C 2~6 alkenyl; 1~6 Alkyl and C 2~6 Each alkenyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a30 , R c30 and R d30 are H and C, respectively. 1~6 independently selected from alkyl, R a60 , R c60 and R d60 are H and C, respectively. 1~6 alkyl.

[0021] In another aspect, the present disclosure provides a compound of Formula I or a pharmaceutically acceptable salt thereof: (In the formula, each ---- independently represent a single bond or a double bond; X is N or CR 7 and; Y is N or C; R 1 and R 2 are H, D, and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, halo, CN, OR a , S.R. a , C(O)R b , C(O)NR c R d , C(O)OR a ,OC(O)R b , OC(O)NR c R d , N.R. c R d , N.R. c C(O)R b , N.R. c C(O)OR a , N.R. c C(O)NR c R d , N.R. c S(O)R b , N.R. c S(O)2R b , N.R. c S(O)NR c R d , S(O)R b , S(O)NR c R d , S(O)2R b , S(O)NR c R d and BR h R i wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 6-membered heteroaryl are each R gand optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is selected from =O and =S; R 3 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 alkylene; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , C(=NR e3 )Rb3 , C(=NOR a3 )R b3 , C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )R b3 , N.R. c3 S(O)R b3 , N.R. c3 S(O)2R b3 , N.R. c3 S(O)NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O)2R b3 , S(O)NR c3 R d3 , and B.R. h3 R i3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R 5 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 alkylene; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl, 5-10 membered heteroaryl, halo, CN, OR a6 , S.R. a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , N.R. c6 S(O)R b6 , N.R. c6 S(O)2R b6 , N.R. c6 S(O)NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O)2R b6 , S(O)NR c6 R d6 and BR h6 R i6 wherein C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a7 , S.R. a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7 , C(=NR e7 )R b7 , C(=NOR a7 )R b7 , C(=NR e7 )NR c7 R d7 , N.R. c7 C(=NR e7 )NR c7 R d7 , N.R. c7 C(=NR e7 )R b7 , N.R. c7 S(O)R b7 , N.R. c7 S(O)2R b7 , N.R. c7 S(O)NR c7 R d7 , S(O)R b7 , S(O)NR c7 R d7 , S(O)2R b7 , S(O)NR c7 R d7 , and B.R. h7 R i7 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is C 3~10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 aryl and 5-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-14 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-14 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a10 , S.R. a10 , C(O)R b10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 , N.R. c10 C(O)NR c10 R d10 , C(=NR e10 )R b10 , C(=NOR a10 )R b10 , C(=NR e10 )NR c10 R d10 , N.R. c10 C(=NR e10 )NR c10 R d10 , N.R. c10 S(O)R b10 , N.R. c10 S(O)2R b10 , N.R. c10 S(O)NR c10 R d10 , S(O)R b10 , S(O)NR c10 R d10 , S(O)2R b10 , S(O)NR c10 R d10 , and B.R. h10 R i10 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 11 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a11 , S.R. a11 , C(O)R b11 , C(O)NR c11 R d11 , C(O)OR a11 ,OC(O)R b11 , OC(O)NR c11 R d11 , N.R. c11 R d11 , N.R. c11 C(O)R b11 , N.R. c11 C(O)OR a11 , N.R. c11 C(O)NR c11 R d11 , N.R. c11 S(O)R b11 , N.R. c11 S(O)2R b11 , N.R. c11 S(O)NR c11 R d11 , S(O)R b11 , S(O)NR c11 R d11 , S(O)2Rb11 , S(O)NR c11 R d11 and BR h11 R i11 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 12 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 12 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a12 , S.R. a12 , C(O)R b12 , C(O)NR c12 R d12 , C(O)OR a12 ,OC(O)R b12 , OC(O)NR c12 R d12 , N.R. c12 R d12 , N.R. c12 C(O)R b12 , N.R. c12 C(O)OR a12 , N.R. c12 C(O)NR c12 R d12 , N.R. c12 S(O)R b12 , N.R. c12 S(O)2R b12 , N.R. c12S(O)NR c12 R d12 , S(O)R b12 , S(O)NR c12 R d12 , S(O)2R b12 , S(O)NR c12 R d12 and BR h12 R i12 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a20 , S.R. a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , N.R. c20 C(O)NR c20 Rd20 , C(=NR e20 )R b20 , C(=NOR a20 )R b20 , C(=NR e20 )NR c20 R d20 , N.R. c20 C(=NR e20 )NR c20 R d20 , N.R. c20 S(O)R b20 , N.R. c20 S(O)2R b20 , N.R. c20 S(O)NR c20 R d20 , S(O)R b20 , S(O)NR c20 R d20 , S(O)2R b20 , S(O)NR c20 R d20 , and B.R. h20 R i20 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a21 , S.R. a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , N.R. c21 C(O)NR c21 R d21 , N.R. c21 S(O)R b21 , N.R. c21 S(O)2R b21 , N.R. c21 S(O)NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 , S(O)2R b21 , S(O)NR c21 R d21 and BR h21 R i21 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3Each alkylene is represented by R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, OR a30 , S.R. a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , N.R. c30 C(O)NR c30 R d30 , N.R. c30 S(O)R b30 , N.R. c30 S(O)2R b30 , N.R. c30 S(O)NR c30 R d30 , S(O)R b30 , S(O)NR c30 R d30 , S(O)2R b30 , S(O)NR c30 R d30 and BR h30 R i30 wherein C is independently selected from 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a31 , S.R. a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , N.R. c31 S(O)Rb31 , N.R. c31 S(O)2R b31 , N.R. c31 S(O)NR c31 R d31 , S(O)R b31 , S(O)NR c31 R d31 , S(O)2R b31 , S(O)NR c31 R d31 and BR h31 R i31 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 32 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a32 , S.R. a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32C(O)OR a32 , N.R. c32 C(O)NR c32 R d32 , N.R. c32 S(O)R b32 , N.R. c32 S(O)2R b32 , N.R. c32 S(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 and BR h32 R i32 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 50 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a50 , S.R. a50 , C(O)R b50 , C(O)NR c50 R d50 , C(O)OR a50 ,OC(O)R b50 , OC(O)NR c50 Rd50 , N.R. c50 R d50 , N.R. c50 C(O)R b50 , N.R. c50 C(O)OR a50 , N.R. c50 C(O)NR c50 R d50 , N.R. c50 S(O)R b50 , N.R. c50 S(O)2R b50 , N.R. c50 S(O)NR c50 R d50 , S(O)R b50 , S(O)NR c50 R d50 , S(O)2R b50 , S(O)NR c50 R d50 and BR h50 R i50 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a51 , S.R. a51 , C(O)Rb51 , C(O)NR c51 R d51 , C(O)OR a51 ,OC(O)R b51 , OC(O)NR c51 R d51 , N.R. c51 R d51 , N.R. c51 C(O)R b51 , N.R. c51 C(O)OR a51 , N.R. c51 C(O)NR c51 R d51 , N.R. c51 S(O)R b51 , N.R. c51 S(O)2R b51 , N.R. c51 S(O)NR c51 R d51 , S(O)R b51 , S(O)NR c51 R d51 , S(O)2R b51 , S(O)NR c51 R d51 and BR h51 R i51 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, C 6~10 Aryl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 52 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 52 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a52 , S.R. a52 , C(O)R b52 , C(O)NR c52 R d52 , C(O)OR a52,OC(O)R b52 , OC(O)NR c52 R d52 , N.R. c52 R d52 , N.R. c52 C(O)R b52 , N.R. c52 C(O)OR a52 , N.R. c52 C(O)NR c52 R d52 , N.R. c52 S(O)R b52 , N.R. c52 S(O)2R b52 , N.R. c52 S(O)NR c52 R d52 , S(O)R b52 , S(O)NR c52 R d52 , S(O)2R b52 , S(O)NR c52 R d52 and BR h52 R i52 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 70 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, NO2, ORa70 , S.R. a70 , C(O)R b70 , C(O)NR c70 R d70 , C(O)OR a70 ,OC(O)R b70 , OC(O)NR c70 R d70 , N.R. c70 R d70 , N.R. c70 C(O)R b70 , N.R. c70 C(O)OR a70 , N.R. c70 C(O)NR c70 R d70 , N.R. c70 S(O)R b70 , N.R. c70 S(O)2R b70 , N.R. c70 S(O)NR c70 R d70 , S(O)R b70 , S(O)NR c70 R d70 , S(O)2R b70 , S(O)NR c70 R d70 and BR h70 R i70 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 71 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 71 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a71 , S.R. a71 , C(O)R b71 , C(O)NR c71 R d71 , C(O)OR a71 ,OC(O)R b71 , OC(O)NR c71 R d71 , N.R. c71 R d71 , N.R. c71 C(O)R b71 , N.R. c71 C(O)OR a71 , N.R. c71 C(O)NR c71 R d71 , N.R. c71 S(O)R b71 , N.R. c71 S(O)2R b71 , N.R. c71 S(O)NR c71 R d71 , S(O)R b71 , S(O)NR c71 R d71 , S(O)2R b71 , S(O)NR c71 R d71 and BR h71 R i71 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 72 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 72 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, halo, D, CN, OR a72 , S.R. a72 , C(O)R b72 , C(O)NR c72 R d72 , C(O)OR a72 ,OC(O)R b72 , OC(O)NR c72 R d72 , N.R. c72 R d72 , N.R. c72 C(O)R b72 , N.R. c72 C(O)OR a72 , N.R. c72 C(O)NR c72 R d72 , N.R. c72 S(O)R b72 , N.R. c72 S(O)2R b72 , N.R. c72 S(O)NR c72 R d72 , S(O)R b72 , S(O)NR c72 R d72 , S(O)2R b72 , S(O)NR c72 R d72 and BR h72 R i72 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a , R b , R c and R d are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c and R d together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h and R i are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h and R i together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a3, R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e3 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h3 and R i3 are OH and C, respectively. 1~6 Alkoxy and C 1~6haloalkoxy; or any R bonded to the same B atom h3 and R i3 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a6 , R b6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h6 and R i6 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h6 and R i6 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a7 , R b7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c7 and R d7 together with the N atom to which they are attached, R 70 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e7 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h7 and R i7 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h7 and R i7 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c10 and R d10 together with the N atom to which they are attached, R 11 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e10 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h10 and R i10 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h10 and R i10 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a11 , R b11 , R c11 and R d11 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 12 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c11 and R d11 together with the N atom to which they are attached, R 12forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h11 and R i11 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h11 and R i11 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a12 , R b12 , R c12 and R d12 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h12 and R i12 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h12 and R i12 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c20 and R d20 together with the N atom to which they are attached, R 21 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R e20 are H, CN, and C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 1~6 Alkylthio, C 1~6 Alkylsulfonyl, C 1~6 Alkyl carbonyl, C 1~6 Alkylaminosulfonyl, Carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl)carbamyl, aminosulfonyl, C 1~6 Alkylaminosulfonyl and di(C 1~6 alkyl)aminosulfonyl; R h20 and R i20 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h20 and R i20together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a21 , R b21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c21 and R d21 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h21 and R i21 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h21 and R i21 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a30 , R b30 , Rc30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h30 and R i30 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h30 and R i30 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a31 , R b31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached, R 32 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h31 and R i31 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h31 and R i31 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a32 , R b32 , R c32 and R d32 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c32 and Rd32 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h32 and R i32 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h32 and R i32 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a50 , R b50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c50 and R d50 together with the N atom to which they are attached, R 51 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h50and R i50 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h50 and R i50 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a51 , R b51 , R c51 and R d51 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 52 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c51 and R d51 together with the N atom to which they are attached, R 52 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h51 and R i51 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h51 and R i51 together with the B atoms to which they are bonded, 1~6Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a52 , R b52 , R c52 and R d52 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c52 and R d52 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h52 and R i52 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h52 and R i52 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a70 , R b70 , R c70 and R d70 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 71 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c70 and R d70 together with the N atom to which they are attached, R 71 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R h70 and R i70 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h70 and R i70 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a71 , R b71 , R c71 and R d71 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl; 1~6 Alkyl C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6Cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl are each R 72 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c71 and R d71 together with the N atom to which they are attached, R 72 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R h71 and R i71 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h71 and R i71 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; R a72 , R b72 , R c72 and R d72 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c72 and R d72 together with the N atom to which they are attached, R g forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Rh72 and R i72 are OH and C, respectively. 1~6 Alkoxy and C 1~6 haloalkoxy; or any R bonded to the same B atom h72 and R i72 together with the B atoms to which they are bonded, 1~6 Alkyl and C 1~6 forming a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from haloalkyl; Each R g D, OH, NO2, CN, halo, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, C 3~6 Cycloalkyl-C 1~2 Alkylene, C 1~6 Alkoxy, C 1~6 Haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 Alkoxy-C 1~3 Alkoxy, HO-C 1~3 Alkoxy, HO-C 1~3 Alkyl, Cyano-C 1~3 Alkyl, H2N-C 1~3 Alkyl, Amino, C 1~6 Alkylamino, di(C 1~6 Alkyl)amino, thio, C 1~6 Alkylthio, C 1~6 Alkylsulfinyl, C 1~6 Alkyl sulfonyl, carbamyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl) carbamyl, carboxy, C 1~6 Alkyl carbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 Alkylcarbonyloxy, aminocarbonyloxy, C 1~6Alkylaminocarbonyloxy, di(C 1~6 alkyl)aminocarbonyloxy, C 1~6 Alkyl sulfonyl amino, amino sulfonyl, C 1~6 Alkylaminosulfonyl, di(C 1~6 Alkyl)aminosulfonyl, aminosulfonylamino, C 1~6 Alkylaminosulfonylamino, di(C 1~6 Alkyl)aminosulfonylamino, aminocarbonylamino, C 1~6 Alkylaminocarbonylamino and di(C 1~6 alkyl)aminocarbonylamino; However, Cy 1 is other than 3,5-dimethylisoxazol-4-yl or 3,5-dimethyl-1H-pyrazol-4-yl).

[0022] In one embodiment, each ---- independently represent a single bond or a double bond; X is N or CR 7 and; Y is N or C; R 1 and R 2 are H, D, and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a , S.R. a , C(O)R b , C(O)NR c R d , C(O)OR a ,OC(O)R b , OC(O)NR c R d , N.R. c R d , N.R. c C(O)R b , N.R. c C(O)OR a , N.R. c C(O)NR c R d , N.R.c S(O)2R b , S(O)2R b and S(O)NR c R d wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is selected from =O and =S; R 3 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 alkylene; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R.c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , N.R. c3 S(O)2R b3 , S(O)2R b3 and S(O)NR c3 R d3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R 5 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3-6 cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, CN, OR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , N.R. c6 S(O)2R b6 , S(O)2R b6 and S(O)NR c6 R d6 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C1~6 Haloalkyl, C 3~6 Cycloalkyl and 4-6 membered heterocycloalkyl, halo, D, CN, OR a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7 , N.R. c7 S(O)2R b7 , S(O)2R b7 and S(O)NR c7 R d7 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is a 4- to 14-membered heterocycloalkyl; the 4- to 14-membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of the 4- to 14-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; the 4- to 14-membered heterocycloalkyl is optionally substituted by R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a10 , C(O)R b10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 , N.R. c10 C(O)NR c10 R d10 , N.R. c10 S(O)2R b10 , S(O)2R b10 and S(O)NR c10 R d10 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 11 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a11 , C(O)R b11 , C(O)NR c11 R d11 , C(O)OR a11 ,OC(O)R b11 , OC(O)NR c11 R d11 , N.R. c11 R d11 , N.R. c11 C(O)R b11 , N.R. c11 C(O)OR a11 , S(O)2R b11 and S(O)NR c11 R d11 are independently selected from; Each R 20 is C1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , N.R. c20 C(O)NR c20 R d20 , N.R. c20 S(O)2R b20 , S(O)2R b20 and S(O)NR c20 R d20 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R.c21 C(O)OR a21 , S(O)2R b21 and S(O)NR c21 R d21 are independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , N.R. c30 C(O)NR c30 R d30 , N.R. c30 S(O)2R b30 , S(O)2R b30 and S(O)NR c30 R d30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , N.R. c31 S(O)2R b31 , S(O)2R b31 and S(O)NR c31 R d31 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 32 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, ORa32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32 C(O)OR a32 , S(O)2R b32 and S(O)NR c32 R d32 are independently selected from; Each R 50 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a50 , C(O)R b50 , C(O)NR c50 R d50 , C(O)OR a50 ,OC(O)R b50 , OC(O)NR c50 R d50 , N.R. c50 R d50 , N.R. c50 C(O)R b50 , N.R. c50 C(O)OR a50 , S(O)2R b50 and S(O)NR c50 R d50 are independently selected from; Each R 70 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, NO2, OR a70 , C(O)R b70 , C(O)NR c70 R d70 , C(O)OR a70 ,OC(O)R b70 , OC(O)NR c70 R d70 , N.R.c70 R d70 , N.R. c70 C(O)R b70 , N.R. c70 C(O)OR a70 , S(O)2R b70 and S(O)NR c70 R d70 are independently selected from; R a , R b , R c and R d are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R b6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached, R g forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a7 , R b7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c7 and Rd7 together with the N atom to which they are attached, R 70 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c10 and R d10 together with the N atom to which they are attached, R 11 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a11 , R b11 , R c11 and R d11 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c20 and R d20 together with the N atom to which they are attached, R 21 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R b21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and Rd30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R b31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 independently selected from cycloalkyl and 4- to 6-membered heterocycloalkyl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached, R 32 forming a 4-, 5-, or 6-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a32 , R b32 , R c32 and R d32 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a50 , R b50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; Ra70 , R b70 , R c70 and R d70 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; Each R g D, OH, CN, halo, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl, C 1~6 Alkoxy, C 1~6 Haloalkoxy, C 1~3 Alkoxy-C 1~3 Alkyl, C 1~3 HO-C 1~3 Alkyl, Cyano-C 1~3 Alkyl, H2N-C 1~3 Alkyl, Amino, C 1~6 Alkylamino, di(C 1~6 Alkyl)amino, C 1~6 Alkylsulfonyl, C 1~6 Alkylcarbamyl, di(C 1~6 Alkyl) carbamyl, carboxy, C 1~6 Alkyl carbonyl, C 1~6 Alkoxycarbonyl, C 1~6 Alkylcarbonylamino, C 1~6 Alkoxycarbonylamino, C 1~6 Alkylcarbonyloxy, C 1~6 Alkylaminocarbonyloxy, di(C 1~6 alkyl)aminocarbonyloxy, C 1~6 Alkylaminocarbonylamino and di(C 1~6 alkyl)aminocarbonylamino.

[0023] In another embodiment, each ---- independently represent a single bond or a double bond; X is N or CR 7 and; Y is N or C; R 1 and R 2 are each independently H or halo; Cy 1 is C 6~10 aryl or 6- to 10-membered heteroaryl, both of which are R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 3 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 selected from aryl and 5-10 membered heteroaryl; R 4 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl and OR a3 heterocycloalkyl and aryl are each selected from R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O and R 5 is H; R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist, and R6 is H; R 7 is H or halo; Cy 2 is R 20 is a 4- to 10-membered heterocycloalkyl optionally substituted by 1 or 2 substituents independently selected from Each R 10 is C 1~6 Alkyl, halo and OR a10 are independently selected from; R 20 is C 1~6 Alkyl, C(O)R b20 , C(O)OR a20 and OC(O)R b20 Selected from; Each R 30 is a 4- to 10-membered heterocycloalkyl, a 5- to 10-membered heteroaryl, halo, OR a30 and NR c30 R d30 heterocycloalkyl and heteroaryl are each independently selected from R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 31 is C 1~6 is alkyl; R a3 is R 30 C optionally substituted with 1, 2, 3 or 4 substituents independently selected from 1~6 is alkyl; R a10 is H; R a20 and R b20 are H and C, respectively. 1~6 Alkyl and C 2~6 alkenyl; R a30 , R c30 and R d30 are each independently H or C 1~6 It is alkyl.

[0024] In another embodiment of Formula I, each ----independently represent a single bond or a double bond; X is N, CH or C-halo; Y is N or C; R 1 and R 2 are each independently H or halo; Cy 1 is C 6~10 aryl or 6-10 membered heteroaryl, both of which are C 1~6 optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, halo, and OH; Or, Cy 1 is C 6~10 aryl or 6-10 membered heteroaryl, both of which are C 4~10 optionally fused to a cycloalkyl or a 4-10 membered heterocycloalkyl; R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 3 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 selected from aryl and 5-10 membered heteroaryl; R 4 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl and OC 1~6 alkyl; alkyl, heterocycloalkyl and aryl are each selected from 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, OH, OC 1~6 Alkyl, NH2, NH(C 1~6 alkyl) and N(C 1~6 alkyl)2; R 5 N ---- YR 6is a single bond and Y is C, then YR 6 is C=O and R 5 is H; R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist, and R 6 is H; Cy 2 is C 1~6 Alkyl, C(O)H, C(O)C 1~6 Alkyl, C(O)C 2~6 Alkenyl, C(O)OH, C(O)OC 1~6 Alkyl, C(O)OC 2~6 Alkenyl, OC(O)H, OC(O)C 1~6 Alkyl and OC(O)C 2~6 and 4-10 membered heterocycloalkyl optionally substituted with 1 or 2 substituents independently selected from alkenyl; alkyl optionally substituted with CN.

[0025] In one embodiment, X is CR 7 In another embodiment, Y is N. In yet another embodiment, Y is C and R 6 is ═O. In yet another embodiment, R 2 is halo. In one embodiment, R 7 is halo. In another embodiment, R 2 and R 7 In yet another embodiment, both of Cy and 1 is C 6~10 aryl or 6- to 10-membered heteroaryl, and the aryl and heteroaryl are each R 10 In yet another embodiment, R 4 is ═O. In one embodiment, R 1 is H.

[0026] In another embodiment, the compound of formula I is a compound of formula II:

[0027] [ka]

[0028] or a pharmaceutically acceptable salt thereof.

[0029] In yet another embodiment of Formula I and Formula II, ---- independently represent a single bond or a double bond; Y is N or C; R 1 and R 2 are H, D, and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a and NR c R d are independently selected from; Cy 1 is C 6~10 aryl and 6-10 membered heteroaryl; each 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of a 6-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 and S(O)2R b3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R 5 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a6 and NR c6 R d6 Selected from; R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a7 and NR c7 R d7 Selected from; Cy 2 is a 4- to 10-membered heterocycloalkyl; the 4- to 10-membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of the 4- to 10-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; the 4- to 10-membered heterocycloalkyl is optionally substituted by R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a10 , C(O)R b10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 and S(O)2R b10 are independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C1~6 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 and S(O)2R b20 are independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 and S(O)2R b30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a31 and NR c31 R d31 are independently selected from; R a , R c and R d are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, and C 1~6 independently selected from haloalkyl; R a7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 independently selected from haloalkyl; R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl.

[0030] In another embodiment, each ---- independently represent a single bond or a double bond; Y is N or C; R 1 and R 2 are each independently H or halo; Cy 1 is C 6~10 aryl or 6- to 10-membered heteroaryl, both of which are R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 4 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl and OR a3 heterocycloalkyl and aryl are each selected from R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O and R 5 is H; R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist, and R 6 is H; R 7 is H or halo; Cy 2 is R 20 is a 4- to 10-membered heterocycloalkyl optionally substituted by 1 or 2 substituents independently selected from Each R 10 is C 1~6 Alkyl, halo and OR a10 are independently selected from; R 20 is C(O)R b20 and; Each R 30 is a 4- to 10-membered heterocycloalkyl, a 5- to 10-membered heteroaryl, halo, OR a30 and NR c30 R d30 heterocycloalkyl and heteroaryl are each independently selected from R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 31 is C 1~6 is alkyl; R a3 is R 30 C optionally substituted with 1, 2, 3 or 4 substituents independently selected from 1~6 is alkyl; R a10 is H; R b20 is H, C 1~6 Alkyl or C 2~6 is alkenyl, R a30 , R c30 and R d30 are each independently H or C 1~6 It is alkyl.

[0031] In yet another embodiment, ---- represents a single or double bond; Y is N or C; R 1 and R 2 are each independently H or halo; Cy 1 is C 6~10 aryl or 6- to 10-membered heteroaryl, both of which are R 10 and optionally substituted with 1 or 2 substituents independently selected from: R 4 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl and OR a3 heterocycloalkyl and aryl are each selected from R 30 and optionally substituted with 1 or 2 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O and R 5 is H; R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist, and R 6 is H; R 7 is H or halo; Cy 2 is R 20 is a 4- to 6-membered heterocycloalkyl optionally substituted by 1 or 2 substituents independently selected from Each R 10 is C 1~6 Alkyl, halo and OR a10 are independently selected from; R 20 is C(O)R b20 , C(O)OR a20 and OC(O)R b20Selected from; Each R 30 Ha, Hello, OR a30 , N.R. c30 R d30 are independently selected from; R a3 is R 30 C optionally substituted with 1, 2, 3 or 4 substituents independently selected from 1~6 is alkyl; R a10 is H; R a20 and R b20 are H and C, respectively. 1~6 Alkyl and C 2~6 alkenyl; R a30 , R c30 and R d30 are each independently H or C 1~6 It is alkyl.

[0032] In one embodiment, the compound of formula I is a compound of formula Ia:

[0033] [ka]

[0034] or a pharmaceutically acceptable salt thereof.

[0035] In another embodiment, the compound of formula I is a compound of formula Ib:

[0036] [ka]

[0037] or a pharmaceutically acceptable salt thereof.

[0038] In yet another embodiment, the compound of formula I is a compound of formula Ic:

[0039] [ka]

[0040] or a pharmaceutically acceptable salt thereof.

[0041] In yet another embodiment, the compound of formula I is a compound of formula Id:

[0042] [ka]

[0043] or a pharmaceutically acceptable salt thereof.

[0044] In one embodiment, the compound of formula I is a compound of formula Ie:

[0045] [ka]

[0046] or a pharmaceutically acceptable salt thereof.

[0047] In another embodiment, the compound of formula I is a compound of formula If:

[0048] [ka]

[0049] or a pharmaceutically acceptable salt thereof.

[0050] In yet another embodiment, the compound of formula I is a compound of formula Ig:

[0051] [ka]

[0052] or a pharmaceutically acceptable salt thereof.

[0053] In yet another embodiment, the compound of formula I is a compound of formula Ih:

[0054] [ka]

[0055] or a pharmaceutically acceptable salt thereof.

[0056] In one embodiment, the compound of formula I is a compound of formula Ii:

[0057] [ka]

[0058] or a pharmaceutically acceptable salt thereof.

[0059] In another embodiment, the compound of formula I is a compound of formula Ij:

[0060] [ka]

[0061] or a pharmaceutically acceptable salt thereof.

[0062] In yet another embodiment, the compound of formula I is a compound of formula Ik:

[0063] [ka]

[0064] or a pharmaceutically acceptable salt thereof.

[0065] In yet another embodiment, the compound of formula I is a compound of formula Im:

[0066] [ka]

[0067] or a pharmaceutically acceptable salt thereof.

[0068] In one embodiment, the compound of formula II is a compound of formula IIa:

[0069] [ka]

[0070] or a pharmaceutically acceptable salt thereof.

[0071] In another embodiment, the compound of formula II is a compound of formula IIb:

[0072] [ka]

[0073] or a pharmaceutically acceptable salt thereof.

[0074] In yet another embodiment, the compound of formula II is a compound of formula IIc:

[0075] [ka]

[0076] or a pharmaceutically acceptable salt thereof.

[0077] In one embodiment of a compound of Formula I or a pharmaceutically acceptable salt thereof, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN; R 2 is H, C 1~6 Alkyl, C 1~6Haloalkyl, Halo, D, CN, OR a2 and NR c2 R d2 C is selected from 1~6 Alkyl is R 22 and optionally substituted with 1 or 2 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3does not exist; R 4 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 and S(O)2R b3 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H, C 1~6 Alkyl and C 1~6 haloalkyl; 1~6 Each alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~6 Alkyl and C 1~6 haloalkyl; R 7 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a7 and NR c7 R d7 Selected from; Cy 2 is selected from 4-10 membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; a ring-forming carbon atom of a 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; a 4-10 membered heterocycloalkyl is selected from R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, halo, D, CN, OR a10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 and S(O)2R b10 are independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 and S(O)2R b20 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a21 and NR c21 R d21 are independently selected from; Each R 22 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D and CN; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R.c30 C(O)R b30 , N.R. c30 C(O)OR a30 and S(O)2R b30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a31 and NR c31 R d31 are independently selected from; Each R 50 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 and NR c50 R d50 wherein C is independently selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a51 and NR c51 R d51 are independently selected from; R a2 , R c2 and R d2 are H and C, respectively. 1~6 Alkyl, C1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 independently selected from aryl and 5-10 membered heteroaryl; or any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group; R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R j3 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R j3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 51and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c50 and R d50 together with the N atom to which they are attached, R 51 forming a 4-, 5-, or 6-membered heterocycloaryl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a51 , R c51 and R d51 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 and independently selected from cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 4- to 7-membered heterocycloalkyl.

[0078] In another embodiment of the compound of Formula I or a pharmaceutically acceptable salt thereof, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 H, D, C 1~3 Alkyl, C 1~3 selected from haloalkyl, halo, and CN; R 2 is H, C 1~3 Alkyl, C 1~3 haloalkyl, halo, D, and CN; 1~3 Alkyl is R 22 and optionally substituted with 1 or 2 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, or 3 ring-forming heteroatoms independently selected from N and O; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, or 3 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is H, C 1~3 Alkyl, C 1~3 haloalkyl, phenyl, and 5- to 6-membered heteroaryl; 1~3 Alkyl, phenyl and 5-6 membered heteroaryl are each R 30 and optionally substituted with 1 or 2 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, C 6~10 Aryl, 5-6 membered heteroaryl, halo, D, CN, OR a3 and NR c3 R j3 C is selected from 1~3 Alkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, C 6~10 Aryl and 5- to 6-membered heteroaryl are each R 30and optionally substituted with 1 or 2 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H, C 1~3 Alkyl and C 1~3 haloalkyl; 1~3 Alkyl is R 50 and optionally substituted with 1 or 2 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~3 Alkyl and C 1~3 haloalkyl; R 7 is H, C 1~3 Alkyl, C 1~3 selected from haloalkyl, halo, D, and CN; Cy 2 is selected from 4- to 6-membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; a ring-forming carbon atom of a 4- to 6-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; a 4- to 6-membered heterocycloalkyl is selected from R 20 and optionally substituted with 1 or 2 substituents independently selected from: Each R 10 is C 1~3 Alkyl, C 1~3 Haloalkyl, C 3-5 Cycloalkyl, halo, D, CN, OR a10 and NR c10R d10 are independently selected from; Each R 20 is C 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl, C 1~3 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 and NR c20 R d20 wherein C is independently selected from 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Each alkynyl is R 21 and optionally substituted with 1 or 2 substituents independently selected from: Each R 21 is C 1~3 Alkyl, C 1~3 Haloalkyl, Halo, D, CN, OR a21 and NR c21 R d21 are independently selected from; Each R 22 is C 1~6 Alkyl, C 1~6 independently selected from haloalkyl, halo, D and CN; Each R 30 is C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 and NR c30 R d30 wherein C is independently selected from 1~3 Alkyl, C 3~6 Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl are each R 31 and optionally substituted with 1 or 2 substituents independently selected from: Each R 31 is C 1~3 Alkyl, C 1~3independently selected from haloalkyl, halo, D and CN; Each R 50 is C 1~3 Alkyl, C 1~3 Haloalkyl, C 3~6 independently selected from cycloalkyl, 4- to 6-membered heterocycloalkyl, halo, D, and CN; 1~3 Alkyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 51 and optionally substituted with 1 or 2 substituents independently selected from: Each R 51 is C 1~3 Alkyl, C 1~3 independently selected from haloalkyl, halo, D and CN; R a3 and R c3 are H and C, respectively. 1~3 Alkyl and C 1~3 haloalkyl; 1~3 Alkyl is R 30 and optionally substituted with 1 or 2 substituents independently selected from: Each R j3 is C 1~3 Alkyl, and C 1~3 haloalkyl; 1~3 Alkyl is R 30 and optionally substituted with 1 or 2 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~3 Alkyl and C 1~3 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~3 Alkyl, C 2~3 Alkenyl, C 2~3 Alkynyl and C 1~3 haloalkyl; 1~3 Alkyl, C2~3 Alkenyl and C 2~3 Each alkynyl is R 21 and optionally substituted with 1 or 2 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a30 , R c30 and R d30 are H and C, respectively. 1~3 Alkyl and C 1~3 haloalkyl; 1~3 Each alkyl is R 31 It may be substituted with one or two substituents independently selected from:

[0079] In yet another embodiment of the compound of Formula I, or a pharmaceutically acceptable salt thereof, each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 is H, C 1~6 Alkyl, C 1~6 haloalkyl, halo, and CN; 1~6 Alkyl is R 22 and optionally substituted with 1 or 2 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6- to 10-membered heteroaryl; 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4is =O; R 3 is C 1~6 Alkyl, C 6~10 aryl and 5-10 membered heteroaryl; 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl and OR a3 C is selected from 1~6 Alkyl, 4-10 membered heterocycloalkyl and C 6~10 Each aryl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H and C 1~6 alkyl; 1~6 Alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is selected from H; R 7 is selected from H and halo; Cy 2is selected from 4-10 membered heterocycloalkyl; R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, halo, CN and OR a10 are independently selected from; Each R 20 is C 1~6 Alkyl, CN, OR a20 , C(O)R b20 and C(O)NR c20 R d20 wherein C is independently selected from 1~6 Alkyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Haloalkyl, Halo, CN, OR a21 and NR c21 R d21 are independently selected from; Each R 22 is CN, Each R 30 is C 1~6 Alkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, OR a30 and NR c30 R d30 wherein C is independently selected from 1~6 Alkyl, 4- to 10-membered heterocycloalkyl, and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 is alkyl; Each R 50 is a 4- to 10-membered heterocycloalkyl; R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1~6is alkyl; Each R a3 is C 1~6 alkyl, and R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R a10 H, and C 1~6 independently selected from alkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 alkynyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1~6 independently selected from alkyl; R a30 , R c30 and R d30 are H and C, respectively. 1~6 alkyl.

[0080] In yet another embodiment of the compound of Formula I or a pharmaceutically acceptable salt thereof, each ---- represents a single or double bond; X is N or CR 7 and; Y is N; or R 1 H, D, C 1~6 Alkyl, C 1~6 selected from haloalkyl, halo, and CN; R 2 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5-10 membered heteroaryl, halo, D, CN, OR a2 and NR c2 R d2 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a single bond, R 4 is =O; R 3 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N ---- CR 4 is a double bond, R 3 does not exist; R 4 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5-10 membered heteroaryl, halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 and S(O)2R b3 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is C=O; R 5 is H, C 1~6 Alkyl and C 1~6 haloalkyl; 1~6 Each alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 and S(O)2R b6 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a7 and NR c7 R d7 C is selected from 1~6 Alkyl is R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is selected from 4-10 membered heterocycloalkyl, each having 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; a ring-forming carbon atom of a 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; a 4-10 membered heterocycloalkyl is selected from R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 and S(O)2R b10 are independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 and S(O)2R b20 wherein C is independently selected from 1~6Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a21 and NR c21 R d21 are independently selected from; Each R 22 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a22 and NR c22 R d22 wherein C is independently selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 23 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 23 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a23 and NR c23 R d23 are independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, ORa30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 and S(O)2R b30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C 1~6 Haloalkyl, Halo, D, CN, OR a31 and NR c31 R d31 are independently selected from; Each R 50 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 and NR c50 R d50 are independently selected from; Each R 60 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , C(O)R b60 , C(O)NRc60 R d60 , C(O)OR a60 ,OC(O)R b60 , OC(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , N.R. c60 C(O)OR a60 and S(O)2R b60 wherein C is independently selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 61 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a61 and NR c61 R d61 are independently selected from; Each R 70 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a70 and NR c70 R d70 are independently selected from; R a2 , R c2 and R d2 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached, R 22 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R j3 is C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R j3 together with the N atom to which they are attached, R 30 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R b6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached, R 60 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from: R a7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c7 and R d7 together with the N atom to which they are attached, R 70 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a22 , R c22 and R d22 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 23 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c22 and R d22 together with the N atom to which they are attached, R 23 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a23 , R c23 and R d23 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a50 , R c50 and R d50 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a60 , R b60 , R c60 and R d60 are H and C, respectively. 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c60 and R d60 together with the N atom to which they are attached, R 61 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a61 , R c61 and R d61 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl; R a70 , Rc70 and R d70 are H and C, respectively. 1~6 Alkyl and C 1~6 independently selected from haloalkyl;

[0081] In another embodiment of Formula II, ---- represents a single or double bond; Y is N or C; R 1 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a1 and NR c1 R d1 Selected from; R 2 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a2 and NR c2 R d2 Selected from; Cy 1 is C 6~10 aryl and 6-10 membered heteroaryl; each 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of a 6-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 and S(O)2R b3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N ---- YR 6 is a single bond and Y is C, then YR 6 is selected from C=O and C=S; R 5 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl; R 5 N ---- YR 6 is a double bond and Y is N, then R 5 and R 6 does not exist; R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist; R 6 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a6 and NR c6 R d6 Selected from; R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a7 and NR c7 R d7 Selected from; Cy 2 is a 4- to 10-membered heterocycloalkyl; the 4- to 10-membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of the 4- to 10-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; the 4- to 10-membered heterocycloalkyl is optionally substituted by R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 and S(O)2R b10 are independently selected from; Each R 20 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 and S(O)2R b20 are independently selected from; Each R 30 is C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 and S(O)2R b30 wherein C is independently selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1~6 Alkyl, C2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, D, CN, OR a31 and NR c31 R d31 are independently selected from; R a1 , R c1 and R d1 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 independently selected from haloalkyl; R a2 , R c2 and R d2 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 independently selected from haloalkyl; R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached, R 30forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a6 , R c6 and R d6 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a7 , R c7 and R d7 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 independently selected from haloalkyl; R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, and C 1~6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 2~6Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: or any R bonded to the same N atom c30 and R d30 together with the N atom to which they are attached, R 31 forming a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a31 , R c31 and R d31 are H and C, respectively. 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl and C 1~6 haloalkyl.

[0082] Further embodiments of the formulas provided herein are provided below.

[0083] In one embodiment, R 1 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a , S.R. a , C(O)R b , C(O)NR c R d , C(O)OR a ,OC(O)R b , OC(O)NR c R d , N.R. c R d , N.R. c C(O)R b , N.R. c C(O)OR a , N.R. c C(O)NR c R d, N.R. c S(O)2R b , S(O)2R b and S(O)NR c R d C is selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g It may be substituted with one or two substituents independently selected from:

[0084] In another embodiment, R 1 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a , S.R. a , C(O)R b , C(O)NR c R d , C(O)OR a ,OC(O)R b , OC(O)NR c R d , N.R. c R d , N.R. c C(O)R b , N.R. c C(O)OR a , N.R. c C(O)NR c R d , N.R. c S(O)2R b , S(O)2R b and S(O)NR c R d is selected from.

[0085] In one embodiment, R 1 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a1 , S.R. a1 , C(O)R b1 , C(O)NR c1 Rd1 , C(O)OR a1 ,OC(O)R b1 , OC(O)NR c1 R d1 , N.R. c1 R d1 , N.R. c1 C(O)R b1 , N.R. c1 C(O)OR a1 , N.R. c1 C(O)NR c1 R d1 , N.R. c1 S(O)2R b1 , S(O)2R b1 and S(O)NR c1 R d1 C is selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g It may be substituted with one or two substituents independently selected from:

[0086] In another embodiment, R 1 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a1 , S.R. a1 , C(O)R b1 , C(O)NR c1 R d1 , C(O)OR a1 ,OC(O)R b1 , OC(O)NR c1 R d1 , N.R. c1 R d1 , N.R. c1 C(O)R b1 , N.R. c1 C(O)OR a1 , N.R. c1 C(O)NR c1 R d1 , N.R. c1 S(O)2R b1 , S(O)2R b1 and S(O)NR c1 R d1is selected from.

[0087] In yet another embodiment, R 1 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 In yet another embodiment, R is selected from haloalkyl, halo, and CN. 1 H, D and C 1~3 In one embodiment, R 1 is H.

[0088] In another embodiment, R 2 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a , S.R. a , C(O)R b , C(O)NR c R d , C(O)OR a ,OC(O)R b , OC(O)NR c R d , N.R. c R d , N.R. c C(O)R b , N.R. c C(O)OR a , N.R. c C(O)NR c R d , N.R. c S(O)2R b , S(O)2R b and S(O)NR c R d C is selected from 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl is R g It may be substituted with one or two substituents independently selected from:

[0089] In another embodiment, R 2 is H, C1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a2 and NR c2 R d2 In another embodiment, R 2 is H, C 1~3 Alkyl, C 1~3 In another embodiment, R is selected from haloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, and CN. 2 is H, C 1~3 It is selected from alkyl, 5-6 membered heteroaryl, halo and CN.

[0090] In yet another embodiment, R 2 H, D, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, Halo, CN, OR a , S.R. a , C(O)R b , C(O)NR c R d , C(O)OR a ,OC(O)R b , OC(O)NR c R d , N.R. c R d , N.R. c C(O)R b , N.R. c C(O)OR a , N.R. c C(O)NR c R d , N.R. c S(O)2R b , S(O)2R b and S(O)NR c R d is selected from.

[0091] In yet another embodiment, R 2 H, D, C 1~6 Alkyl, C1~6 In another embodiment, R is selected from haloalkyl, halo, and CN. 2 is C 1~6 Alkyl, C 1~6 In one embodiment, R is selected from haloalkyl and halo. 2 is halo. In another embodiment, R 2 is chloro.

[0092] In one embodiment, R 2 is H, C 1~6 Alkyl, C 1~6 haloalkyl, halo, and CN; 1~6 Alkyl is R 22 It may be substituted with one or two substituents independently selected from:

[0093] In yet another embodiment, Cy 1 is C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0094] In yet another embodiment, Cy 1 is C 6~10aryl and 6-10 membered heteroaryl; each 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, or 3 ring-forming heteroatoms independently selected from N, O, and S; N and S are optionally oxidized; a ring-forming carbon atom of a 6-10 membered heteroaryl is optionally substituted by oxo to form a carbonyl group; C 6~10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0095] In one embodiment, Cy 1 is selected from phenyl, naphthalenyl, quinolinyl, isoquinolinyl, indazolyl, chromanyl, 2,3-dihydro-1H-indenyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, and pyridinyl; phenyl, naphthalenyl, quinolinyl, isoquinolinyl, indazolyl, chromanyl, 2,3-dihydro-1H-indenyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, and pyridinyl are each selected from R 10 In one embodiment, Cy is optionally substituted with 1, 2, or 3 substituents independently selected from 1 is selected from phenyl, naphthalenyl, and indazolyl; phenyl, naphthalenyl, quinolinyl, isoquinolinyl, indazolyl, chromanyl, 2,3-dihydro-1H-indenyl, and 2,3-dihydrobenzo[b][1,4]dioxinyl are, respectively, R 10 In another embodiment, R 10 is halo or OH.

[0096] In yet another embodiment, Cy 1 is selected from 3-hydroxy-naphthalen-1-yl, 2-fluoro-6-hydroxyphenyl, 2-fluoro-3-hydroxyphenyl and 5-methyl-1H-indazol-4-yl.

[0097] In another embodiment, Cy 1 is C6~10 aryl or 6- to 10-membered heteroaryl, both of which are substituted by one or two R 10 In yet another embodiment, Cy 1 is one or two R 10 C optionally substituted with 6~10 In yet another embodiment, R 10 is halo. In one embodiment, Cy 1 is one or two R 10 In another embodiment, R 10 is C 1~6 In yet another embodiment, Cy is selected from alkyl, halo, and OH. 1 is a 5- to 10-membered heteroaryl, provided that Cy 1 is other than 3,5-dimethylisoxazol-4-yl or 3,5-dimethyl-1H-pyrazol-4-yl.

[0098] In one embodiment, X is N. In another embodiment, X is CR 7 is.

[0099] In yet another embodiment, R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl and 4-6 membered heterocycloalkyl, halo, D, CN, OR a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7、 NR c7 S(O)2R b7 , S(O)2R b7 and S(O)NR c7 R d7 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0100] In yet another embodiment, R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~6 Cycloalkyl and 4-6 membered heterocycloalkyl, halo, D, CN, OR a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7 、 NR c7 S(O)2R b7 , S(O)2R b7 and S(O)NR c7 R d7 is selected from.

[0101] In one embodiment, R 7 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6Haloalkyl, C 3~6 Cycloalkyl and 4-6 membered heterocycloalkyl, halo, D, CN, OR a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 ,OC(O)R b7 , OC(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , N.R. c7 C(O)NR c7 R d7 、 NR c7 S(O)2R b7 , S(O)2R b7 and S(O)NR c7 R d7 is selected from.

[0102] In another embodiment, R 7 H, D, C 1~6 Alkyl, C 1~6 In one embodiment, R is selected from haloalkyl, halo, and CN. 7 is selected from H and halo. In yet another embodiment, R 7 is halo. In yet another embodiment, R 7 is fluoro.

[0103] In one embodiment, R 3 N ---- CR 4 is a single bond, R 4 is ═O. In another embodiment, R 3 N ---- CR 4 is a single bond, R 4 is =S. In yet another embodiment, R 3 N ---- CR 4 If is a double bond, R 3 does not exist.

[0104] In yet another embodiment, R 3 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5- to 10-membered heteroaryl; 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0105] In one embodiment, R 3 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 aryl and 5-10 membered heteroaryl. In another embodiment, R 3 is H, C 1~6 Alkyl, C 1~6 haloalkyl, phenyl, and 5- to 6-membered heteroaryl; 1~6 Alkyl, phenyl and 5-6 membered heteroaryl are each R 30 In another embodiment, R 3 is C 1~6 alkyl, phenyl, and 5- to 6-membered heteroaryl; 1~3 Alkyl, phenyl and 5-6 membered heteroaryl are each R 30 It may be substituted with one or two substituents independently selected from:

[0106] In another embodiment, R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 1~6 Haloalkyl, C 3~10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , N.R. c3 S(O)2R b3 , S(O)2R b3 and S(O)NR c3 R d3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0107] In yet another embodiment, R 4 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5-10 membered heteroaryl, halo, D, CN, OR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 C(O)R b3 and S(O)2R b3 C is selected from 1~6 Alkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0108] In yet another embodiment, R 4 is H, C 1~6 Alkyl, C 1~6 Haloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 and NR c3 R d3 C is selected from 1~6 Alkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0109] In another embodiment, R 4 is H, C 1~6 Alkyl, C 2~6 Alkenyl, C 2~6Alkynyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene, 5-10 membered heteroaryl-C 1~3 Alkylene, Halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , N.R. c3 S(O)2R b3 , S(O)2R b3 and S(O)NR c3 R d3 C is selected from 1~6 Alkyl, C 2~6 Alkenyl, C 2~6 Alkynyl, C 3~10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6~10 Aryl, 5-10 membered heteroaryl, C 3~10 Cycloalkyl-C 1~3 Alkylene, 4-10 membered heterocycloalkyl-C 1~3 Alkylene, C 6~10 Aryl-C 1~3 Alkylene and 5-10 membered heteroaryl-C 1~3 Each alkylene is represented by R 30and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0110] In yet another embodiment, R 4 is H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R j3 , N.R. c3 C(O)R b3 , and S(O)2R b3 wherein said C is selected from 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0111] In yet another embodiment, R 4 is H, C 1-6 Alkyl, C 1-6 Haloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a3 , and NR c3 R j3 wherein said C is selected from 1-6 Alkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0112] In one embodiment, R 4 is H, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5- to 10-membered heteroaryl, and OR a3 wherein said 4 to 10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 30 It may be substituted with one or two substituents independently selected from:

[0113] In one embodiment, R 4 is H, 4-10 membered heterocycloalkyl, C 6-10 Aryl and OR a3 wherein said 4 to 10 membered heterocycloalkyl, and C 6-10 Each aryl is R 30 In another embodiment, R 4 is selected from H, 1-(methylpyrrolidin-2-yl)methoxy, 1-(methyl-1H-pyrazol-5-yl)methoxy, 3-(dimethylamino)azetidin-1-yl, 3-hydroxynaphthalen-1-yl, and 2-fluoro-6-hydroxyphenyl.

[0114] In one embodiment, R 4 is selected from 3-(dimethylamino)-azetidin-1-yl, 3-(dimethylamino)-3-methylazetidin-1-yl, ((S)-1-methylpyrrolidin-2-yl)methoxy, ((S)-1-(dimethylamino)propan-2-yl)oxy, and 2-methyl-1H-imidazol-1-yl.

[0115] In one embodiment, R 4 is H, 4-10 membered heterocycloalkyl, C 6-10 Aryl and OR a3 wherein heterocycloalkyl and aryl are each selected from one or two R 30 In another embodiment, R 4 is one or two R 30C optionally substituted with 6-10 In yet another embodiment, R 30 is independently OH or halo. In another embodiment, R 4 is one or two R 30 and optionally substituted 4- to 10-membered heterocycloalkyl.

[0116] In yet another embodiment, R 4 is OR a3 and; R a3 is R 30 C replaced with 1-6 is alkyl; R 30 is a 4- to 6-membered heterocycloalkyl or a 5- to 10-membered heteroaryl, both of which are C 1-3 It may be substituted with alkyl.

[0117] In one embodiment, R 30 is C 1-3 In another embodiment, R 30 is C 1-3 It is a pyrazole which may be substituted with alkyl.

[0118] In yet another embodiment, R 4 is NR c30 R d30 In yet another embodiment, R c30及び R d30 are C 1-3 It is alkyl.

[0119] In yet another embodiment, Y is N. In yet another embodiment, Y is C. In another embodiment, R 5 N ---- YR 6 is a single bond, Y is C, and YR 6 is C=O. In yet another embodiment, R 5 N ---- YR 6 is a single bond, Y is C, and YR6 In yet another embodiment, R 5 N ---- YR 6 is a single bond, Y is N, and YR 6 is NH. In another embodiment, R 5 N ---- YR 6 is a double bond, Y is N, and R 5 and R 6 is absent. In another embodiment, R 5 N ---- YR 6 is a double bond and Y is C, then R 5 does not exist.

[0120] In one embodiment, R 5 is H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 aryl, and 5- to 10-membered heteroaryl, wherein said C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 50 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0121] In another embodiment, R 5 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 cycloalkyl, and 4- to 6-membered heterocycloalkyl; 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 50 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0122] In yet another embodiment, R 5 is H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-6 In yet another embodiment, R 5 is H. In another embodiment, R 5 is H, C 1-6 Alkyl, and C 1-6 haloalkyl; wherein said C 1-6 Alkyl is R 50 In another embodiment, R 5 is H, C 1-3 alkyl; wherein said C 1-3 Alkyl is R 50 It may be substituted with one or two substituents independently selected from:

[0123] In one embodiment, R 6 H, D, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, CN, OR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , N.R. c6 S(O)2R b6 , S(O)2R b6 , and S(O)NRc6 R d6 wherein said C is selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R g and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0124] In another embodiment, R 6 is H, C 1-3 Alkyl, C 1-3 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, OR a6 , and NR c6 R d6 wherein said C is selected from 1-3 Alkyl, C 3-6 Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl are each R 60 In another embodiment, R 6 is H, C 1-3 alkyl, 4- to 6-membered heterocycloalkyl, and 5- to 6-membered heteroaryl; 1-3 Alkyl, 4- to 6-membered heterocycloalkyl, and 5- to 6-membered heteroaryl are each R 60 In yet another embodiment, R 6 is H, C 1-6 Alkyl, C 1-6 Haloalkyl, OR a6 , and NR c6 R d6 is selected from.

[0125] In another embodiment, R 6 H, D, C 1-6 Alkyl, C 1-6 Haloalkyl, OR a6 , and NR c6 Rd6 wherein said C is selected from 1-6 Alkyl is R g It may be substituted with one or two substituents independently selected from:

[0126] In yet another embodiment, R 6 H, D, C 1-6 Alkyl, C 1-6 Haloalkyl, OR a6 , and NR c6 R d6 In yet another embodiment, R 6 is H.

[0127] In one embodiment, Cy 2 is a 4- to 14-membered heterocycloalkyl; wherein the 4- to 14-membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein N and S are optionally oxidized; wherein a ring-forming carbon atom of the 4- to 14-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; wherein the 4- to 14-membered heterocycloalkyl is 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0128] In another embodiment, Cy 2 is a 4- to 10-membered heterocycloalkyl; wherein the 4- to 10-membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein N and S are optionally oxidized; wherein a ring-forming carbon atom of the 4- to 10-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; wherein the 4- to 10-membered heterocycloalkyl is 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0129] In yet another embodiment, Cy 2is a 4- to 6-membered heterocycloalkyl; wherein the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of the 4- to 6-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; wherein the 4- to 6-membered heterocycloalkyl is 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0130] In yet another embodiment, Cy 2 is selected from 4-(piperidin-1-yl)prop-2-en-1-one, 3-(piperidin-1-yl)prop-2-en-1-one, 3-(azetidin-1-yl)prop-2-en-1-one, and 3-(pyrrolidin-1-yl)prop-2-en-1-one. 2 is 4-(piperidin-1-yl)prop-2-en-1-one. In another embodiment, Cy 2 is 3-(piperidin-1-yl)prop-2-en-1-one. In yet another embodiment, Cy 2 is 3-(azetidin-1-yl)prop-2-en-1-one. 2 is 3-(pyrrolidin-1-yl)prop-2-en-1-one.

[0131] In one embodiment, Cy 2 is one or two R 20 In yet another embodiment, R 20 is C(O)R b20 is.

[0132] In one embodiment, Cy 2 teeth

[0133] [Table 1]

[0134] is selected from.

[0135] In another embodiment, Cy 2 teeth

[0136] [Table 2]

[0137] Selected from (wherein n is 0, 1 or 2).

[0138] In yet another embodiment, Cy 2 teeth,

[0139] [Table 3]

[0140] Selected from (wherein n is 0, 1 or 2).

[0141] In one embodiment, Cy 2 Cy 2 In one embodiment, Cy 2 Cy 2 In one embodiment, Cy 2 Cy 2 In one embodiment, Cy 2 Cy 2 In one embodiment, Cy 2 Cy 2 -e.

[0142] In some embodiments, n is 0. In some embodiments, n is 1. In some embodiments, n is 2.

[0143] In another embodiment, Cy 2 Cy 2 -a, Cy 2 -b, Cy 2 -c, Cy 2 -d, and Cy 2-e, where n is 0.

[0144] In one embodiment, Cy 2 Cy 2 In another embodiment, Cy 2 Cy 2 In yet another embodiment, Cy 2 Cy 2 In yet another embodiment, Cy 2 Cy 2 -d1. In some embodiments, n is 0. In other embodiments, n is 1. In yet other embodiments, n is 2.

[0145] In another embodiment, each R 10 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a10 , C(O)R b10 , C(O)NR c10 R d10 , C(O)OR a10 ,OC(O)R b10 , OC(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 , N.R. c10 C(O)NR c10 R d10 , N.R. c10 S(O)2R b10 , S(O)2R b10 , and S(O)NR c10 R d10 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0146] In another embodiment, each R 10 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a10 , C(O)NR c10 R d10 , C(O)OR a10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , and S(O)2R b10 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 11 It may be substituted with one or two substituents independently selected from:

[0147] In yet another embodiment, each R 10 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, Halo, D, CN, OR a10 , and NR c10 R d10 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is R 11 It may be substituted with one or two substituents independently selected from:

[0148] In yet another embodiment, each R 10 is C 1-6 Alkyl, C 1-6Haloalkyl, Halo, D, CN, OR a10 , and NR c10 R d10 In one embodiment, each R 10 is C 1-6 Alkyl, Halo, and OR a10 In another embodiment, each R 10 is independently selected from methyl, fluoro, and hydroxyl. 10 are independently selected from F, Cl, CH3 and CF3.

[0149] In yet another embodiment, each R 11 is C 1-6 Alkyl, C 1-6 Haloalkyl, Halo, D, CN, OR a11 , C(O)R b11 , C(O)NR c11 R d11 , C(O)OR a11 ,OC(O)R b11 , OC(O)NR c11 R d11 , N.R. c11 R d11 , N.R. c11 C(O)R b11 , N.R. c11 C(O)OR a11 , S(O)2R b11 , and S(O)NR c11 R d11 In yet another embodiment, each R 11 is C 1-6 Alkyl, C 1-6 Haloalkyl, Halo, D, CN, OR a11 , and NR c11 R d11 are independently selected from

[0150] In some embodiments, each R 20 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , N.R. c20 C(O)NR c20 R d20 , N.R. c20 S(O)2R b20 , S(O)2R b20 , and S(O)NR c20 R d20 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0151] In another embodiment, each R 20 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 , S(O)2R b20 , and S(O)NR c20 R d20 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0152] In another embodiment, each R 20 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 ,OC(O)R b20 , OC(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , and S(O)2R b20 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is R 21 In another embodiment, each R 20 is C 1-3 Alkyl, C 2-3 Alkenyl, C 2-3 Alkynyl, C 1-3 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 , and NR c20 R d20 wherein C is independently selected from 1-3 Alkyl, C 2-3 Alkenyl, and C 2-3 Each alkynyl is R 21In another embodiment, each R 20 is C 1-3 Alkyl, CN, OR a20 , C(O)R b20 , and C(O)NR c20 R d20 wherein C is independently selected from 1-3 Each alkyl is R 21 It may be substituted with one or two substituents independently selected from:

[0153] In yet another embodiment, each R 20 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 , S(O)2R b20 , and S(O)NR c20 R d20 are independently selected from

[0154] In some embodiments, each R 20 is C 1-6 Alkyl, CN, OR a20 , and C(O)NR c20 R d20 wherein C is independently selected from 1-6 Alkyl is R 21 It may be substituted with one or two substituents independently selected from:

[0155] In yet another embodiment, each R 20 is C 1-6 Alkyl, CN, C(O)R b20 , C(O)OR a20 , and S(O)2R b20 In one embodiment, each R 20 is C(O)R b20In another embodiment, each R 20 is prop-2-en-1-one.

[0156] In some embodiments, each R 21 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, Halo, D, CN, OR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , S(O)2R b21 , and S(O)NR c21 R d21 In another embodiment, each R 21 is C 1-6 Alkyl, C 1-6 Haloalkyl, halo, D, CN, and OR a21 In another embodiment, each R 21 is C 1-3 Alkyl, C 1-3 In another embodiment, each R 21 is CN.

[0157] In yet another embodiment, each R 21 is C 1-6 Haloalkyl, Halo, CN, OR a21 , and NR c21 R d21 In yet another embodiment, each R 21 are independently selected from CF3, F, Cl, CN, OH, OCH3, NH2, NHCH3, and N(CH3)2.

[0158] In one embodiment, R 22 is CN.

[0159] In yet another embodiment, each R 30 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C 1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene, 5-10 membered heteroaryl-C 1-3 Alkylene, Halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , N.R. c30 C(O)NR c30 R d30 , N.R. c30 S(O)2R b30 , S(O)2R b30 , and S(O)NR c30 R d30 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, C 3-10 Cycloalkyl-C 1-3 Alkylene, 4-10 membered heterocycloalkyl-C1-3 Alkylene, C 6-10 Aryl-C 1-3 Alkylene and 5-10 membered heteroaryl-C 1-3 Each alkylene is represented by R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0160] In yet another embodiment, each R 30 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 ,OC(O)R b30 , OC(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , S(O)2R b30 , and S(O)NR c30 R d30 wherein C is independently selected from 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0161] In some embodiments, each R 30 is C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , and NR c30 R d30 wherein C is independently selected from 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0162] In another embodiment, each R 30 is a 4- to 10-membered heterocycloalkyl, a 5- to 10-membered heteroaryl, a halo, OR a30 , and NR c30 R d30 wherein the 4- to 10-membered heterocycloalkyl and the 5- to 10-membered heteroaryl are each independently selected from R 31 In another embodiment, each R 30 is C 1-3 Alkyl, C 1-3 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 , and NR c30 R d30 wherein C is independently selected from 1-3 Alkyl, C 3-6 Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl are each R 31 In another embodiment, each R 30 is C 1-3 Alkyl, 4-6 membered heterocycloalkyl, 5-6 membered heteroaryl, halo, OR a30 , and NR c30 R d30 wherein C is independently selected from 1-3Alkyl, 4- to 6-membered heterocycloalkyl, and 5- to 6-membered heteroaryl are each R 31 It may be substituted with one or two substituents independently selected from:

[0163] In yet another embodiment, each R 31 is C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , N.R. c31 S(O)2R b31 , S(O)2R b31 , and S(O)NR c31 R d31 wherein said C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 32 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0164] In yet another embodiment, each R 31 is C 1-6 Alkyl, Halo, D, CN, OR a31 , and NR c31 R d31 In one embodiment, each R31 is independently C 1-6 In another embodiment, each R 31 are independently methyl.

[0165] In some embodiments, each R 50 is C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a50 , and NR c50 R d50 wherein C is independently selected from 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl and 5- to 10-membered heteroaryl are each R 51 In another embodiment, each R 50 is C 1-3 Alkyl, C 1-3 Haloalkyl, C 3-6 independently selected from cycloalkyl, 4- to 6-membered heterocycloalkyl, halo, D, and CN; 1-3 Alkyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 51 In another embodiment, each R 50 is a 4- to 6-membered heterocycloalkyl; wherein each of said 4- to 6-membered heterocycloalkyl is R 51 It may be substituted with one or two substituents independently selected from:

[0166] In some embodiments, each R 51 is C 1-6 Alkyl, C 1-6 Haloalkyl, Halo, D, CN, OR a51 , and NR c51 R d51In another embodiment, each R 51 is C 1-3 Alkyl, C 1-3 In one embodiment, each R 51 is C 1-3 It is alkyl.

[0167] In some embodiments, each R 60 is C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , C(O)R b60 , C(O)NR c60 R d60 , C(O)OR a60 ,OC(O)R b60 , OC(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , N.R. c60 C(O)OR a60 , and S(O)2R b60 In one embodiment, each R 60 is C 1-3 Alkyl, C 1-3 Haloalkyl, C 3-6 Cycloalkyl, 4-6 membered heterocycloalkyl, halo, D, CN, OR a60 , and NR c60 R d60 In one embodiment, each R 60 is C 1-3 Alkyl, 4-6 membered heterocycloalkyl, OR a60 , and NR c60 R d60 are independently selected from

[0168] In another embodiment, each R 60 is C 1-6 Alkyl, C 1-6Haloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR a60 , C(O)NR c60 R d60 and NR c60 R d60 wherein C is independently selected from 1-6 Alkyl and 4- to 10-membered heterocycloalkyl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0169] In yet another embodiment, each R 61 is C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a61 , and NR c61 R d61 In yet another embodiment, each R 61 is independently selected from 4- to 6-membered heterocycloalkyl.

[0170] In some embodiments, each R a3 , R b3 , R c3 and R d3 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 1-6 haloalkyl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0171] In some embodiments, each R j3 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 1-6haloalkyl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0172] In another embodiment, each R a3 , R b3 , R c3 and R d3 is H, C 1-6 Alkyl, and C 1-6 haloalkyl; wherein said C 1-6 Alkyl is R 30 It may be substituted with one or two substituents independently selected from:

[0173] In another embodiment, each R j3 is H, C 1-6 Alkyl, and C 1-6 haloalkyl; wherein said C 1-6 Alkyl is R 30 It may be substituted with one or two substituents independently selected from:

[0174] In yet another embodiment, each R a3 is independently C 1-6 alkyl; 1-6 Alkyl is R 30 In yet another embodiment, each R a3 are independently methyl; wherein said methyl is R 30 is substituted with one substituent independently selected from

[0175] In some embodiments, each R a10 , R b10 , R c10 and R d10 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C1-6 Haloalkyl, C 3-6 cycloalkyl, and 4- to 6-membered heterocycloalkyl; 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0176] In another embodiment, each R a10 , R b10 , R c10 and R d10 is H, C 1-6 Alkyl, and C 1-6 In yet another embodiment, each R a10 H, and C 1-6 In yet another embodiment, each R a10 are independently H.

[0177] In some embodiments, each R a20 , R b20 , R c20 and R d20 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Haloalkyl, C 3-6 cycloalkyl, and 4- to 6-membered heterocycloalkyl; 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from:

[0178] In another embodiment, each R a20 , R b20 , R c20 and R d20is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 haloalkyl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is R 21 It may be substituted with one or two substituents independently selected from:

[0179] In yet another embodiment, each R b20 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 In yet another embodiment, each R b20 is independently C 2-6 In one embodiment, each R b20 are independently ethylenyl (vinyl).

[0180] In some embodiments, each R b20 is C 2-6 Alkenyl and C 2-6 alkynyl; wherein said C 2-6 Alkenyl and C 2-6 Each alkynyl is R 21 In another embodiment, each R b20 is C 2-3 Alkenyl and C 2-3 alkynyl; wherein said C 2-3 Alkenyl, and C 2-3 Each alkynyl is R 21 It may be substituted with one or two substituents independently selected from:

[0181] In another embodiment, each R a30 , R b30 , R c30 and R d30 is H, C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, and C 1-6 haloalkyl; wherein said C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is R 31 and optionally substituted with 1, 2, or 3 substituents independently selected from:

[0182] In yet another embodiment, each R a30 , R b30 , R c30 and R d30 is H, C 1-6 Alkyl, and C 1-6 haloalkyl; wherein said C 1-6 Alkyl is R 31 In yet another embodiment, each R a30 , R c30 and R d30 H, and C 1-6 In yet another embodiment, each R a30 , R c30 and R d30 is independently selected from H and methyl.

[0183] In another embodiment, each R a60 , R b60 , R c60 and R d60 is H, C 1-6 Alkyl, and C 1-6 haloalkyl. In one embodiment, each R a60 , R c60 and R d60 is H, C 1-3 Alkyl, C 1-3 haloalkyl.

[0184] In another embodiment, Cy 1is other than 3,5-dimethylisoxazol-4-yl, 3,5-dimethyl-1H-pyrazol-4-yl or 4-(1-oxo-2-propen-1-yl)phenyl.

[0185] In another embodiment, the compound of the formula herein is a compound of the formula: or a pharmaceutically acceptable salt thereof.

[0186] In another embodiment, the compound of formula I is 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(2-fluoro-3-hydroxyphenyl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(5-methyl-1H-indazol-4-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)azetidin-1-yl)prop-2-en-1-one; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methyl-1H-pyrazol-5-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(1-acryloylpiperidin-4-yl)-8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 1-(4-(8-chloro-6-fluoro-4,7-bis(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-4,7-bis(2-fluoro-6-hydroxyphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)-piperidin-1-yl)prop-2-en-1-one; and 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one is selected from.

[0187] In another embodiment, the compound of formula I is 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-2-methyl-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-(1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-fluoro-2-methyl-phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(o-tolyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidine-2-carboxamide; 1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidine-2-carbonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)-6-chloronaphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)-6-methylnaphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-(1H-pyrazol-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 1-(1-acryloylazetidin-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-(2-isopropyl-4-methyl-pyridin-3-yl)-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione; 1-(1-acryloylazetidin-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-(2-isopropyl-4-methyl-pyridin-3-yl)-3-((1-methylpyrrolidin-2-yl)methyl)-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione; 1-(1-acryloylazetidin-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)-4-methylpyrrolidin-1-yl)prop-2-en-1-one; 1-((trans)-3-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one; 1-((trans)-3-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-4-methylpyrrolidin-1-yl)prop-2-en-1-one; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-2-yl)acetonitrile; 1-(1-acryloylpyrrolidin-3-yl)-8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-methyl-1,5-dihydro-4H-imidazo[4,5-c]quinolin-4-one; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-8-methyl-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3,8-diazabicyclo[3.2.1]octan-8-yl)-8-chloro-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(5-methyl-1H-indazol-4-yl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(5-hydroxy-2-methylphenyl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(3-fluoro-2-methylphenyl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2,3-dimethylphenyl)-6-fluoro-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2,3-dihydro-1H-inden-4-yl)-6-fluoro-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-phenyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-2-((dimethylamino)methyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinoline-8-carbonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-hydroxy-2,3-dimethylphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-hydroxy-2-methylphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2-chloro-5-hydroxyphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-fluoro-5-hydroxyphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-fluorophenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2-chlorophenyl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2-chloro-3-fluorophenyl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,4-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,5-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(chroman-8-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-methoxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(4-fluoro-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(8-methyl-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-5-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-8-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(quinolin-8-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(quinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-2-(hydroxymethyl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(2-(2-aminoethyl)-1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-2-(piperidin-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-2-(1-methyl-1H-imidazol-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; and 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-2-yl)tetrahydro-2H-thiopyran 1,1-dioxide is selected from.

[0188] In yet another embodiment, the compound of formula I is 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(5-methyl-2,5-diazaspiro[3.4]octan-2-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(5-methyl-2,5-diazaspiro[3.4]octan-2-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-4-fluorophenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(5-chloro-4-methylpyridin-3-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(5-chloro-2-methoxy-4-methylpyridin-3-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(3-oxomorpholino)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(4-methyl-2-oxopiperazin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(2-oxopiperidin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 3-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 3-(8-chloro-1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(3-chloro-2-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(4-methylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(m-tolyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(4,5-dimethylpyridin-3-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(m-tolyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(4-fluoro-2,3-dimethylphenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2-cyclopropylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((R)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(2-methyl-1H-imidazol-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(2-methyl-1H-imidazol-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(2-methyl-1H-imidazol-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-7-(4-fluorophenyl)-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(6-fluoro-7-(4-fluorophenyl)-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(4-(((S)-1-(dimethylamino)-propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(4-(3-(dimethylamino)-azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-1,5-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-8-methyl-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4-(dimethylamino)but-2-enoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4-(dimethylamino)but-2-enoyl)-4-(6-fluoro-8-methyl-4-(2-methyl-1H-imidazol-1-yl)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 1-((2S,4S)-1-Acryloyl-2-(cyanomethyl)piperidin-4-yl)-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carbonitrile; 1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carbonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(2-methylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(2-methylpyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(4-fluoro-3-methylphenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)aceto...

Claims

1. Compounds of Formula I: 【Chemistry 1】 or a pharma- ceutically acceptable salt thereof (In the formula, Each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 alkylene, halo, D, and CN; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 5-10 membered heteroaryl; each of the 4-10 membered heterocycloalkyl and the 5-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 5-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N----CR 4 If ---- is a single bond, R 4 is selected from =O and =S; R 3 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 alkylene; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N----CR 4 If ---- is a double bond, R 3 does not exist; R 4 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , O.C.(O)R b3 , O-C(O)NR c3 Rd3, NR c3 C(O)R b3 , N.R. c3 C(O)OR a3 , and N.R. c3 C(O)NR c3 Rd3; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a single bond and Y is C, YR 6 is selected from C=O and C=S; R 5 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 alkylene; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a double bond and Y is N, R 5 and R 6 does not exist; R 5 N----YR 6 When ---- is a double bond and Y is C, R 5 does not exist; R 6 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 alkylene; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a7 , S.R. a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 , O.C.(O)R b7 , O-C(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , and N.R. c7 C(O)NR c7 Rd7; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is a 4- to 14-membered heterocycloalkyl; the 4- to 14-membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; N and S are optionally oxidized; a ring-forming carbon atom of the 4- to 14-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; the 4- to 14-membered heterocycloalkyl is optionally substituted by R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a10 , S.R. a10 , C(O)R b10 , C(O)NR c10 R d10 , C(O)OR a10 , O.C.(O)R b10 , O-C(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 and N.R. c10 C(O)NR c10 Rd10 is independently selected from 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 11 is selected independently from the halo; Each R 20 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a20 , S.R. a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 , O.C.(O)R b20 , O-C(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , and N.R. c20 C(O)NR c20 Rd20 is independently selected from 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a21 , S.R. a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 , O.C.(O)R b21 , O-C(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , and N.R. c21 C(O)NR c21 R d21 are independently selected from; Each R 22 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 independently selected from alkylene, halo, D, and CN; 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 23 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 23 is CN; Each R 30 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a30 , S.R. a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 , O.C.(O)R b30 , O-C(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , N.R. c30 C(O)OR a30 , and N.R. c30 C(O)NR c30 Rd30; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; Each R 50 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 alkylene; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; Each R 60 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a60 , S.R. a60 , C(O)R b60 , C(O)NR c60 R d60 , C(O)OR a60 , O.C.(O)R b60 , O-C(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , N.R. c60 C(O)OR a60 , and N.R. c60 C(O)NR c60 Rd60; 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 61 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 independently selected from alkylene; Each R 70 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 independently selected from alkylene; R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl, and C 2～6 Each alkynyl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a7 , R b7 , R c7 and R d7 are H and C, respectively. 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 independently selected from aryl and 5-10 membered heteroaryl; R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl, and C 2～6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R b21 , R c21 and R d21 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Each alkynyl is R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a60 , R b60 , R c60 and R d60 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl, and C 2～6 Each alkynyl is R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: However, Cy 1 is other than 3,5-dimethylisoxazol-4-yl, 3,5-dimethyl-1H-pyrazol-4-yl or 4-(1-oxo-2-propen-1-yl)phenyl).

2. Each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl, 5-10 membered heteroaryl, halo, D, and CN; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 22 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 1 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 6-10 membered heteroaryl; each of the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; N and S are optionally oxidized; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl are optionally substituted by oxo to form a carbonyl group; C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N----CR 4 If ---- is a single bond, R 4 is =O; R 3 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 5- to 10-membered heteroaryl; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N----CR 4 If ---- is a double bond, R 3 does not exist; R 4 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , O.C.(O)R b3 , O-C(O)NR c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , and N.R. c3 C(O)NR c3 Rd3; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a single bond and Y is C, YR 6 is C=O; R 5 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 cycloalkyl, and 4 to 10 membered heterocycloalkyl; 1～6 Alkyl, C 3～10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a double bond and Y is N, R 5 and R 6 does not exist; R 5 N----YR 6 When ---- is a double bond and Y is C, R 5 does not exist; R 6 , H, C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 alkylene; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 60 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 7 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a7 , S.R. a7 , C(O)R b7 , C(O)NR c7 R d7 , C(O)OR a7 , O.C.(O)R b7 , O-C(O)NR c7 R d7 , N.R. c7 R d7 , N.R. c7 C(O)R b7 , N.R. c7 C(O)OR a7 , and N.R. c7 C(O)NR c7 Rd7; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 70 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Cy 2 is selected from 4- to 14-membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; N and S are optionally oxidized; a ring-forming carbon atom of a 4- to 14-membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; and a 4- to 14-membered heterocycloalkyl is selected from R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR a10 , S.R. a10 , C(O)NR c10 R d10 , C(O)OR a10 , O.C.(O)R b10 , O-C(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , N.R. c10 C(O)OR a10 , and N.R. c10 C(O)NR c10 Rd10 is independently selected from 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 11 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 11 is selected independently from the halo; Each R 20 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, halo, D, CN, OR a20 , S.R. a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 , O.C.(O)R b20 , O-C(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , N.R. c20 C(O)OR a20 , and N.R. c20 C(O)NR c20 Rd20 is independently selected from 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl and 4- to 10-membered heterocycloalkyl are each R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, Halo, D, CN, OR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 , O.C.(O)R b21 , O-C(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , and N.R. c21 C(O)ORa21 independently selected from; Each R 22 is C 1～6 Alkyl, C 1～6 independently selected from haloalkyl, halo, D, and CN; Each R 30 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene, 5-10 membered heteroaryl-C 1～3 Alkylene, Halo, D, CN, OR a30 , S.R. a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 , O.C.(O)R b30 , O-C(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , and N.R. c30 C(O)ORa30; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, C 3～10 Cycloalkyl-C 1～3 Alkylene, 4-10 membered heterocycloalkyl-C 1～3 Alkylene, C 6～10 Aryl-C 1～3 Alkylene and 5-10 membered heteroaryl-C 1～3 Each alkylene is R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; Each R 50 is C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl, and 5- to 10-membered heteroaryl; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1～6 Alkyl and C 1～6 independently selected from haloalkyl; Each R 60 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a60 , S.R. a60 , C(O)R b60 , C(O)NR c60 R d60 , C(O)OR a60 , O.C.(O)R b60 , O-C(O)NR c60 R d60 , N.R. c60 R d60 , N.R. c60 C(O)R b60 , and N.R. c60 C(O)ORa60; 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 61 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl, and C 2～6 Each alkynyl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl, and C 2～6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R b21 , R c21 and R d21 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 Each alkynyl is R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a60 , R b60 , R c60 and R d60 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 Each alkynyl is R 61 and optionally substituted with 1, 2, 3 or 4 substituents independently selected from 2. The compound of claim 1.

3. Each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 , H, C 1～6 Alkyl, C 1～6 haloalkyl, halo, D and CN; 1～6 Alkyl is R 22 and optionally substituted with 1 or 2 substituents independently selected from: Cy 1 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 6-10 membered heteroaryl; the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl each have at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; the ring-forming carbon atoms of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N----CR 4 If ---- is a single bond, R 4 is =O; R 3 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 5- to 10-membered heteroaryl; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 3 N----CR 4 If ---- is a double bond, R 3 does not exist; R 4 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5-10 membered heteroaryl, halo, D, CN, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)OR a3 , O.C.(O)R b3 , O-C(O)NR c3 R d3 , N.R. c3 C(O)R b3 , and N.R. c3 C(O)ORa3; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a single bond and Y is C, YR 6 is C=O; R 5 is H, C 1～6 Alkyl and C 1～6 haloalkyl; 1～6 Each alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a double bond and Y is N, R 5 and R 6 does not exist; R 5 N----YR 6 When ---- is a double bond and Y is C, R 5 does not exist; R 6 , H, C 1～6 Alkyl and C 1～6 haloalkyl; R 7 , H, C 1～6 Alkyl, C 1～6 Haloalkyl, Halo, D, CN, OR a7 and N.R. c7 R d7 Selected from; Cy 2 is selected from 4- to 10-membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; a ring-forming carbon atom of a 4- to 10-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; a 4- to 10-membered heterocycloalkyl is selected from R 20 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 10 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, halo, D, CN, OR a10 , C(O)NR c10 R d10 , C(O)OR a10 , O.C.(O)R b10 , O-C(O)NR c10 R d10 , N.R. c10 R d10 , N.R. c10 C(O)R b10 , and N.R. c10 C(O)ORa10 are independently selected from; Each R 20 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 , O.C.(O)R b20 , O-C(O)NR c20 R d20 , N.R. c20 R d20 , N.R. c20 C(O)R b20 , and N.R. c20 C(O)ORa20; 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1～6 Alkyl, C 1～6 Haloalkyl, Halo, D, CN, OR a21 and N.R. c21 R d21 are independently selected from; Each R 22 is C 1～6 Alkyl, C 1～6 independently selected from haloalkyl, halo, D and CN; Each R 30 is C 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl, halo, D, CN, OR a30 , C(O)R b30 , C(O)NR c30 R d30 , C(O)OR a30 , O.C.(O)R b30 , O-C(O)NR c30 R d30 , N.R. c30 R d30 , N.R. c30 C(O)R b30 , and N.R. c30 C(O)ORa30; 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1～6 Alkyl, and C 1～6 independently selected from haloalkyl; Each R 50 is C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl, and 5- to 10-membered heteroaryl; 1～6 Alkyl, C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 51 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 51 is C 1～6 Alkyl, and C 1～6 independently selected from haloalkyl; R a3 , R b3 , R c3 and R d3 are H and C, respectively. 1～6 Alkyl and C 1～6 haloalkyl; 1～6 Each alkyl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl, and C 1～6 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1～6 Alkyl and C 1～6 independently selected from haloalkyl; R a30 , R b30 , R c30 and R d30 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl, C 2～6 Alkynyl and C 1～6 haloalkyl; 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 Each alkynyl is R 31 and optionally substituted with 1, 2, 3 or 4 substituents independently selected from 3. The compound according to claim 1 or 2, or a pharma- ceutically acceptable salt thereof.

4. The compound of formula I may be prepared by reacting a compound of formula II: 【Chemistry 2】 or a pharma- ceutically acceptable salt thereof.

5. Each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 is H, C 1～3 Alkyl, C 1～3 haloalkyl, halo, D and CN; 1～3 Alkyl is R 22 and optionally substituted with 1 or 2 substituents independently selected from: Cy 1 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 6-10 membered heteroaryl; each of the 4-10 membered heterocycloalkyl and the 6-10 membered heteroaryl has at least one ring-forming carbon atom and 1, 2 or 3 ring-forming heteroatoms independently selected from N and O; a ring-forming carbon atom of the 6-10 membered heteroaryl and the 4-10 membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 6- to 10-membered heteroaryl are each R 10 and optionally substituted with 1, 2 or 3 substituents independently selected from: R 3 N----CR 4 If ---- is a single bond, R 4 is =O; R 3 , H, C 1～3 Alkyl, C 1～3 haloalkyl, phenyl, and 5- to 6-membered heteroaryl; 1～3 Alkyl, phenyl and 5- to 6-membered heteroaryl are each R 30 and optionally substituted with 1 or 2 substituents independently selected from: R 3 N----CR 4 If ---- is a double bond, R 3 does not exist; R 4 , H, C 1～3 Alkyl, C 1～3 Haloalkyl, C 3～6 Cycloalkyl, 4-6 membered heterocycloalkyl, C 6～10 aryl, 5- to 6-membered heteroaryl, halo, D, CN, and ORa3; 1～3 Alkyl, C 3～6 Cycloalkyl, 4-6 membered heterocycloalkyl, C 6～10 Aryl and 5- to 6-membered heteroaryl are each R 30 and optionally substituted with 1 or 2 substituents independently selected from: R 5 N----YR 6 When ---- is a single bond and Y is C, YR 6 is C=O; R 5 is H, C 1～3 Alkyl and C 1～3 haloalkyl; 1～3 Alkyl is R 50 and optionally substituted with 1 or 2 substituents independently selected from: R 5 N----YR 6 When ---- is a double bond and Y is N, R 5 and R 6 does not exist; R 5 N----YR 6 When ---- is a double bond and Y is C, R 5 does not exist; R 6 , H, C 1～3 Alkyl and C 1～3 haloalkyl; R 7 , H, C 1～3 Alkyl, C 1～3 selected from haloalkyl, halo, D, and CN; Cy 2 is selected from 4- to 6-membered heterocycloalkyl, each having at least one ring-forming carbon atom and 1, 2, 3 or 4 ring-forming heteroatoms independently selected from N, O and S; a ring-forming carbon atom of a 4- to 6-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; a 4- to 6-membered heterocycloalkyl is selected from R 20 and optionally substituted with 1 or 2 substituents independently selected from: Each R 10 is C 1～3 Alkyl, C 1～3 Haloalkyl, C 3-5 Cycloalkyl, halo, D, CN, OR a10 and N.R. c10 R d10 are independently selected from; Each R 20 is C 1～3 Alkyl, C 2～3 Alkenyl, C 2～3 Alkynyl, C 1～3 Haloalkyl, Halo, D, CN, OR a20 , C(O)R b20 , C(O)NR c20 R d20 , C(O)OR a20 and N.R. c20 R d20 Independently selected from the group consisting of C 1～3 Alkyl, C 2～3 Alkenyl and C 2～3 Each alkynyl is R 21 and optionally substituted with 1 or 2 substituents independently selected from: Each R 21 is C 1～3 Alkyl, C 1～3 Haloalkyl, Halo, D, CN, OR a21 and N.R. c21 R d21 are independently selected from; Each R 22 is C 1～6 Alkyl, C 1～6 independently selected from haloalkyl, halo, D and CN; Each R 30 is C 1～3 Alkyl, C 1～3 Haloalkyl, C 3～6 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, D, CN, OR a30 and N.R. c30 R d30 Independently selected from the group consisting of C 1～3 Alkyl, C 3～6 Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl are each R 31 and optionally substituted with 1 or 2 substituents independently selected from: Each R 31 is C 1～3 Alkyl, and C 1～3 independently selected from haloalkyl; Each R 50 is C 1～3 Alkyl, C 1～3 Haloalkyl, C 3～6 cycloalkyl, and 4- to 6-membered heterocycloalkyl; 1～3 Alkyl, C 3～6 Cycloalkyl and 4- to 6-membered heterocycloalkyl are each R 51 may be substituted with one or two substituents selected from Each R 51 is C 1～3 Alkyl, and C 1～3 independently selected from haloalkyl; R a3 and R c3 are H and C, respectively. 1～3 Alkyl and C 1～3 haloalkyl; 1～3 Alkyl is R 30 and optionally substituted with 1 or 2 substituents independently selected from: R a10 , R b10 , R c10 and R d10 are H and C, respectively. 1～3 Alkyl and C 1～3 independently selected from haloalkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1～3 Alkyl, C 2～3 Alkenyl, C 2～3 Alkynyl and C 1～3 haloalkyl; 1～3 Alkyl, C 2～3 Alkenyl and C 2～3 Each alkynyl is R 21 and optionally substituted with 1 or 2 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1～6 Alkyl and C 1～6 independently selected from haloalkyl; R a30 , R c30 and R d30 are H and C, respectively. 1～3 Alkyl and C 1～3 haloalkyl; 1～3 Each alkyl is R 31 5. The compound according to claim 4, or a pharma- ceutically acceptable salt thereof, optionally substituted with 1 or 2 substituents independently selected from:

6. Each ---- represents a single or double bond; X is N or CR 7 and; Y is N or C; R 1 is H; R 2 is H, C 1～6 Alkyl and C 1～6 haloalkyl, halo, and CN; 1～6 Alkyl is R 22 and optionally substituted with 1 or 2 substituents independently selected from: Cy 1 is C 3～10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl and 6- to 10-membered heteroaryl; each independently R 10 and optionally substituted with 1, 2, 3 or 4 substituents selected from; R 3 N----CR 4 If ---- is a single bond, R 4 is =O; R 3 is C 1～6 Alkyl, C 6～10 aryl and 5-10 membered heteroaryl; each independently R 30 and optionally substituted with 1, 2, 3 or 4 substituents selected from; R 3 N----CR 4 If ---- is a double bond, R 3 does not exist; R 4 is H, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl and OR a3 C is selected from 1～6 Alkyl, 4-10 membered heterocycloalkyl and C 6～10 Each aryl is R 30 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a single bond and Y is C, YR 6 is C=O; R 5 H and C 1～6 alkyl; 1～6 Alkyl is R 50 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R 5 N----YR 6 When ---- is a double bond and Y is N, R 5 and R 6 does not exist; R 5 N----YR 6 When ---- is a double bond and Y is C, R 5 does not exist; R 6 is H; R 7 is selected from H and halo; Cy 2 is 4 to 10 membered heterocycloalkyl, and independently R 20 and optionally substituted with 1, 2, 3 or 4 substituents selected from; Each R 10 is C 1～6 Alkyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, halo, CN and OR a10 are independently selected from; Each R 20 is C 1～6 Alkyl, CN, OR a20 , C(O)R b20 and C(O)NR c20 R d20 Independently selected from the group consisting of C 1～6 Alkyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 21 is C 1～6 Haloalkyl, Halo, CN, OR a21 and N.R. c21 R d21 are independently selected from; Each R 22 is CN, Each R 30 is C 1～6 Alkyl, 4-10 membered heterocycloalkyl, 5-10 membered heteroaryl, halo, OR a30 and N.R. c30 R d30 Independently selected from the group consisting of C 1～6 Alkyl, 4- to 10-membered heterocycloalkyl, and 5- to 10-membered heteroaryl are each R 31 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: Each R 31 is C 1～6 is alkyl; Each R 50 is 4 to 10 membered heterocycloalkyl, and independently R 51 and optionally substituted with 1, 2, 3 or 4 substituents selected from; Each R 51 is C 1～6 is alkyl; Each R a3 is C 1～6 alkyl, and each independently R 30 and optionally substituted with 1, 2, 3 or 4 substituents selected from; Each R a10 H, and C 1～6 independently selected from alkyl; R a20 , R b20 , R c20 and R d20 are H and C, respectively. 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 alkynyl; 1～6 Alkyl, C 2～6 Alkenyl and C 2～6 Each alkynyl is R 21 and optionally substituted with 1, 2, 3, or 4 substituents independently selected from: R a21 , R c21 and R d21 are H and C, respectively. 1～6 independently selected from alkyl; R a30 , R c30 and R d30 are H and C, respectively. 1～6 3. The compound of claim 1 or 2, or a pharma- ceutically acceptable salt thereof, wherein: R is independently selected from the group consisting of aryl, aryl, aryl and aryl;

7. The compound of formula II may be a compound of formula IIa: 【Chemistry 3】 or a pharma- ceutically acceptable salt thereof.

8. The compound of formula II may be prepared by reacting a compound of formula IIb: 【Chemistry 4】 or a pharma- ceutically acceptable salt thereof.

9. The compound of formula II may be a compound of formula IIc: 【Chemistry 5】 or a pharma- ceutically acceptable salt thereof.

10. The compound of formula I may be a compound of formula Ig: 【Chemistry 6】 or a pharma- ceutically acceptable salt thereof.

11. The compound of formula I may be a compound of formula Ie: 【Chemistry 7】 or a pharma- ceutically acceptable salt thereof.

12. R 2 is H, C 1～3 Alkyl, C 1～3 The compound of claim 1 or 4, wherein the alkyl group is selected from haloalkyl, phenyl, 5-6 membered heteroaryl, halo, D and CN.

13. R 2 is C 1～6 Alkyl, C 1～6 13. The compound of claim 12, selected from haloalkyl and halo.

14. Cy 1 is C 6～10 is selected from aryl and 6- to 10-membered heteroaryl; the 6- to 10-membered heteroaryl has at least one ring-forming carbon atom and 1, 2, or 3 ring-forming heteroatoms independently selected from N, O, and S; N and S may be oxidized; a ring-forming carbon atom of the 6- to 10-membered heteroaryl may be substituted by oxo to form a carbonyl group; C 6～10 Aryl and 6- to 10-membered heteroaryl are each R 10 5. The compound according to claim 1 or 4, optionally substituted with 1, 2 or 3 substituents independently selected from:

15. The compound according to any one of claims 1 to 3, wherein X is N.

16. X is CR 7 The compound according to any one of claims 1 to 3,

17. R 7 is halo.

18. R 3 N----CR 4 ---- is a single bond, and R 4 The compound of any one of claims 1 to 3, wherein is =O.

19. R 3 N----CR 4 ---- is a double bond, and R 3 The compound according to any one of claims 1 to 3, wherein is absent.

20. R 3 is H, C 1～6 Alkyl, C 1～6 haloalkyl, phenyl, and 5- to 6-membered heteroaryl; 1～6 Alkyl, phenyl and 5- to 6-membered heteroaryl are each R 30 The compound according to any one of claims 1 to 3, optionally substituted with 1 or 2 substituents independently selected from:

21. R 4 is H, C 1～6 Alkyl, C 1～6 Haloalkyl, 4-10 membered heterocycloalkyl, C 6～10 aryl, 5-10 membered heteroaryl, halo, D, CN, and ORa3; 1～6 Alkyl, 4-10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 30 5. The compound according to claim 1 or 4, optionally substituted with 1, 2 or 3 substituents independently selected from:

22. R 4 is H, 4-10 membered heterocycloalkyl, C 6～10 Aryl, 5-10 membered heteroaryl and OR a3 said 4 to 10 membered heterocycloalkyl, C 6～10 Aryl and 5- to 10-membered heteroaryl are each R 30 22. The compound of claim 21, optionally substituted with 1 or 2 substituents independently selected from:

23. The compound according to any one of claims 1 to 6, wherein Y is N.

24. The compound according to any one of claims 1 to 6, wherein Y is C.

25. R 5 N----YR 6 ---- is a single bond, Y is C, and YR 6 The compound according to any one of claims 1 to 6, wherein is C=O.

26. R 5 N----YR 6 ---- is a double bond, Y is C, and R 5 The compound according to any one of claims 1 to 6, wherein is absent.

27. R 5 N----YR 6 ---- is a double bond, Y is N, and R 5 and R 6 The compound according to any one of claims 1 to 6, wherein is absent.

28. R 5 H and C 1～6 alkyl; 1～6 Alkyl is R 50 The compound according to any one of claims 1 to 6, optionally substituted with 1 or 2 substituents independently selected from:

29. R 5 is H.

30. Cy 2 is a 4- to 6-membered heterocycloalkyl; the 4- to 6-membered heterocycloalkyl has at least one ring-forming carbon atom and 1 or 2 ring-forming heteroatoms independently selected from N, O and S; a ring-forming carbon atom of the 4- to 6-membered heterocycloalkyl may be substituted by oxo to form a carbonyl group; the 4- to 6-membered heterocycloalkyl is R 20 5. The compound of claim 1 or 4, optionally substituted with 1, 2, 3 or 4 substituents independently selected from:

31. Cy 2 teeth 【Table 1】 is selected from 31. The compound of claim 30, wherein n is 0, 1 or 2.

32. The compound of formula I is 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(2-fluoro-3-hydroxyphenyl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(5-methyl-1H-indazol-4-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)azetidin-1-yl)prop-2-en-1-one; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methyl-1H-pyrazol-5-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(1-acryloylpiperidin-4-yl)-8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 1-(4-(8-chloro-6-fluoro-4,7-bis(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-4,7-bis(2-fluoro-6-hydroxyphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one; 1-(4-(8-chloro-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)-piperidin-1-yl)prop-2-en-1-one; and 1-(4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-1-yl)prop-2-en-1-one The compound according to any one of claims 1 to 11, selected from:

33. The compound of formula I is 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-2-methyl-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-(1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-fluoro-2-methyl-phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(o-tolyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidine-2-carboxamide; 1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidine-2-carbonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)-6-chloronaphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)-6-methylnaphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-(1H-pyrazol-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 1-(1-acryloylazetidin-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-(2-isopropyl-4-methyl-pyridin-3-yl)-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione; 1-(1-acryloylazetidin-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-(2-isopropyl-4-methyl-pyridin-3-yl)-3-((1-methylpyrrolidin-2-yl)methyl)-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione; 1-(1-acryloylazetidin-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione; 1-(3-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methylpyrrolidin-2-yl)-methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)-4-methylpyrrolidin-1-yl)prop-2-en-1-one; 1-((trans)-3-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one; 1-((trans)-3-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-4-methylpyrrolidin-1-yl)prop-2-en-1-one; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-2-yl)acetonitrile; 1-(1-acryloylpyrrolidin-3-yl)-8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-5-methyl-1,5-dihydro-4H-imidazo[4,5-c]quinolin-4-one; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-8-methyl-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3,8-diazabicyclo[3.2.1]octan-8-yl)-8-chloro-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(5-methyl-1H-indazol-4-yl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(5-hydroxy-2-methylphenyl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-6-fluoro-7-(3-fluoro-2-methylphenyl)-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2,3-dimethylphenyl)-6-fluoro-4-((1-methyl-pyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-7-(2,3-dihydro-1H-inden-4-yl)-6-fluoro-4-((1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-phenyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-2-((dimethylamino)methyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinoline-8-carbonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-hydroxy-2,3-dimethylphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-hydroxy-2-methylphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2-chloro-5-hydroxyphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-fluoro-5-hydroxyphenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-fluorophenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2-chlorophenyl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2-chloro-3-fluorophenyl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,4-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,5-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(chroman-8-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-methoxy-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(4-fluoro-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(8-methyl-naphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-7-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-5-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-8-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(quinolin-8-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-(1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(quinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-2-(hydroxymethyl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(2-(2-aminoethyl)-1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethyl-amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-2-(piperidin-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-2-(1-methyl-1H-imidazol-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; and 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-2-yl)tetrahydro-2H-thiopyran 1,1-dioxide The compound according to any one of claims 1 to 11, selected from:

34. The compound of formula I is 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(5-methyl-2,5-diazaspiro[3.4]octan-2-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(5-methyl-2,5-diazaspiro[3.4]octan-2-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-4-fluorophenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(5-chloro-4-methylpyridin-3-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(5-chloro-2-methoxy-4-methylpyridin-3-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(3-oxomorpholino)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(4-methyl-2-oxopiperazin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(2-oxopiperidin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 3-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 3-(8-chloro-1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(3-chloro-2-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(4-methylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(m-tolyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(4,5-dimethylpyridin-3-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(m-tolyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-2-methylbenzonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(4-fluoro-2,3-dimethylphenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(2-cyclopropylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((R)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(2-methyl-1H-imidazol-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(2-methyl-1H-imidazol-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(2-methyl-1H-imidazol-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(4-fluorophenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-6-fluoro-7-(4-fluorophenyl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-7-(4-fluorophenyl)-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(6-fluoro-7-(4-fluorophenyl)-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(4-(((S)-1-(dimethylamino)-propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(((S)-1-(dimethylamino)propan-2-yl)oxy)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(4-(3-(dimethylamino)-azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-1,5-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-6-fluoro-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-8-methyl-4-(2-methyl-1H-imidazol-1-yl)-7-phenyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4-(dimethylamino)but-2-enoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4-(dimethylamino)but-2-enoyl)-4-(6-fluoro-8-methyl-4-(2-methyl-1H-imidazol-1-yl)-7-(2-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-((E)-4,4-difluorobut-2-enoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(2-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)azetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-7-(2,3-dimethylphenyl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 1-((2S,4S)-1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carbonitrile; 1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinoline-8-carbonitrile; 2-((2S,4S)-1-Acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(2-methylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(2-methylpyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(isoquinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-6-fluoro-7-(4-fluoro-3-methylphenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-(2-fluoroacryloyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(5,6-dimethyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6-fluoro-7-(4-fluoro-3-methylphenyl)-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-7-(5-methyl-1H-indazol-4-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4,4-difluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(6-fluoro-5-methyl-1H-indazol-4-yl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(6-fluoro-5-methyl-1H-indazol-4-yl)-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-methoxybut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S)-1-acryloyl-4-(8-chloro-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(m-tolyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-Acryloyl-4-(8-chloro-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(m-tolyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-Acryloyl-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-(but-2-ynoyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-Acryloyl-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(ethyl(methyl)amino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-acryloyl-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-acryloyl-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S)-1-(but-2-ynoyl)-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-Acryloyl-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(ethyl(methyl)amino)-azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 8-(1-((2S)-1-acryloyl-2-(cyanomethyl)piperidin-4-yl)-8-chloro-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-7-yl)-1-naphthonitrile; 2-((2S)-1-acryloyl-4-(7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-(but-2-ynoyl)-4-(7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-acryloyl-4-(7-(8-chloronaphthalen-1-yl)-4-(3-(ethyl(methyl)amino)azetidin-1-yl)-6-fluoro-8-methyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-(but-2-ynoyl)-4-(7-(8-chloronaphthalen-1-yl)-4-(3-(ethyl(methyl)amino)azetidin-1-yl)-6-fluoro-8-methyl-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S)-1-acryloyl-4-(7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-8-(trifluoromethyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-8-(trifluoromethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)-piperidin-4-yl)-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)propanenitrile; 3-(7-(6-chloro-5-methyl-1H-indazol-4-yl)-1-((2S,4S)-2-(cyanomethyl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)propanenitrile; 2-((2S,4S)-1-acryloyl-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(5-fluoroquinolin-8-yl)-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-7-(3-chloro-2-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)propanenitrile; 3-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-7-(2-chloro-3-methylphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)propanenitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(3-chloro-2-methoxyphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(3-chloro-2-methoxyphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-7-(2-methoxy-3-methylphenyl)-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-methoxy-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-(trifluoromethyl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 3-(1-((2S,4S)-1-(but-2-ynoyl)-2-(cyanomethyl)piperidin-4-yl)-7-(3-chloro-2-methoxyphenyl)-6-fluoro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-8-yl)propanenitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(2-methyl-1H-imidazol-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)-3-methylazetidin-1-yl)-6-fluoro-8-methyl-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(3-oxomorpholino)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(3-oxomorpholino)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(7-(2-chloro-3-methylphenyl)-6-fluoro-8-methyl-4-(3-oxomorpholino)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-1-((E)-4-fluorobut-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)-1-((E)-4-(dimethylamino)but-2-enoyl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methyl-2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(8-chloronaphthalen-1-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(6-fluoro-5-methyl-1H-indazol-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-7-(6-chloro-5-methyl-1H-indazol-4-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(1-methylisoquinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(8-chloro-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-methylisoquinolin-4-yl)-1H-imidazo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6,8-dichloro-7-(5-fluoroquinolin-8-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(5-fluoroquinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(6,8-dichloro-7-(3-chloro-2-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6,8-dichloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(5-fluoroquinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(5-fluoroquinolin-8-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6,8-dichloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(quinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6,8-dichloro-7-(2,3-dichlorophenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6,8-dichloro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(quinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-(but-2-ynoyl)-4-(6,8-dichloro-7-(6-fluoroquinolin-8-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(6,8-dichloro-7-(2,3-dichlorophenyl)-4-(3-(dimethylamino)azetidin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(2-chloro-3-methylphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-Acryloyl-4-(6,8-dichloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(quinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-4-(3-(dimethylamino)azetidin-1-yl)-7-(6-fluoroquinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(2,3-dichlorophenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(2-chloro-3-methylphenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(3-chloro-2-methylphenyl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(quinolin-8-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(6-fluoroquinolin-8-yl)-4-(((S)-1-methylpyrrolidin-2-yl)methoxy)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 2-((2S,4S)-1-acryloyl-4-(6,8-dichloro-7-(3-chloro-2-methoxyphenyl)-4-(3-(dimethylamino)azetidin-1-yl)-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)piperidin-2-yl)acetonitrile; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(7-fluoronaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-2-ethyl-6-fluoro-7-(7-fluoro-3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-8-yl)propanenitrile; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-(3-(dimethylamino)azetidin-1-yl)-7-(3-hydroxynaphthalen-1-yl)-6-phenoxy-1H-imidazo[4,5-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(6-benzyl-1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-(3-(dimethylamino)azetidin-1-yl)-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-2-yl)-N,N-dimethylpropanamide; 4-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-2-(2-(methylamino)ethyl)-8-(1H-pyrazol-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)naphthalen-2-ol; 3-(1-((endo)-2-((1H-pyrrol-2-yl)methyl)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-2-ethyl-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-8-yl)propanenitrile; 5-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-2-(3-(dimethylamino)-3-oxopropyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-4-yl)-2-fluoro-N-methylbenzamide; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-imidazo[4,5-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanobenzyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-2-yl)-N,N-dimethylpropanamide; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-((3-oxomorpholino)methyl)-1H-imidazo[4,5-c]quinolin-8-yl)propanenitrile; 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-8-(2-cyanoethyl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-1H-imidazo[4,5-c]quinolin-2-yl)-N-methyl-N-(pyridin-2-ylmethyl)propanamide; and 3-(1-((endo)-2-azabicyclo[2.1.1]hexan-5-yl)-4-(3-(dimethylamino)azetidin-1-yl)-6-fluoro-7-(3-hydroxynaphthalen-1-yl)-2-(2-(piperazin-1-yl)thiazol-4-yl)-1H-imidazo[4,5-c]quinolin-8-yl)propanenitrile; or a pharma- ceutically acceptable salt thereof The compound according to any one of claims 1 to 11, selected from:

35. A pharmaceutical composition comprising a compound according to any one of claims 1 to 34, or a pharma- ceutically acceptable salt thereof, and at least one pharma- ceutically acceptable carrier or excipient.

36. 36. The pharmaceutical composition of claim 35 for inhibiting KRAS activity.

37. 36. The pharmaceutical composition of claim 35 for treating a disease or disorder associated with the activity of KRAS interacting.

38. The pharmaceutical composition according to claim 35, for treating a disease or disorder associated with the activity of a KRAS protein having a G12C mutation.

39. 36. The pharmaceutical composition of claim 35 for treating cancer in a patient.

40. 40. The pharmaceutical composition of claim 39, wherein the cancer is selected from carcinoma, hematological cancer, sarcoma, and glioblastoma.

41. The pharmaceutical composition described in claim 40, wherein the cancer is a blood cancer selected from myeloproliferative neoplasms, myelodysplastic syndromes, chronic and juvenile myelomonocytic leukemia, acute myeloid leukemia, acute lymphocytic leukemia, and multiple myeloma.

42. The pharmaceutical composition of claim 40, wherein the cancer is a carcinoma selected from pancreatic, colorectal, lung, bladder, gastric, esophageal, breast, head and neck, cervical, skin and thyroid.

43. 38. The pharmaceutical composition of claim 37, wherein the disease or disorder is an immunological or inflammatory disorder.

44. 44. The pharmaceutical composition of claim 43, wherein the immunological or inflammatory disorder is a Ras-associated lymphoproliferative disorder or juvenile myelomonocytic leukemia caused by a somatic mutation of KRAS.

Images