Method for mixing substances, vape liquid, and device for generating vape liquid

Abstract

To provide a mixing method of substances difficult to precipitate crystals of a fat soluble substance.SOLUTION: A mixing method executes: a first mixing step of mixing a first liquid and a fat soluble substance in a state heated to 70°C or higher; a first additive charging step of adding a first additive to a substance obtained in the first mixing step; and a second mixing step of adding a second liquid to a substance obtained in the first additive charging step and stirring it. The first liquid is composed of PG (propylene glycol). The second liquid is composed of VG (vegetable glycerin). The fat soluble substance is composed of cannabinoids, mainly CBD (cannabidiol). The first additive has a hydrogen bonding term in the Hansen solubility parameters having a value between a hydrogen bonding term of the first liquid and a hydrogen bonding term of the fat soluble substance, and has a polarization term in the Hansen solubility parameters having a value between a polarization term of the first liquid and a polarization term of the fat soluble substance.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a method for mixing substances and the like.

Background Art

[0002] Conventionally, as in Patent Document 1, liquid compositions for electronic cigarettes and the like have been proposed.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, when containing a fat-soluble substance such as CBD (cannabidiol) at a high concentration, it was necessary to avoid precipitation of crystals.

[0005] Therefore, an object of the present invention is to provide a method for mixing substances and the like in which crystals of fat-soluble substances are less likely to precipitate.

Means for Solving the Problems

[0006] The mixing method according to the present invention includes a first mixing step of mixing a first liquid and a fat-soluble substance in a state heated to 70°C or higher, a first additive input step of adding a first additive to the substance obtained in the first mixing step, and a second mixing step of adding a second liquid to the substance obtained in the first additive input step and performing stirring. The first liquid is composed of PG (propylene glycol). The second liquid is composed of VG (vegetable glycerin). The fat-soluble substance is composed of cannabinoids mainly including CBD (cannabidiol). The first additive has a hydrogen bonding term in the Hansen solubility parameter that is between the hydrogen bonding term of the first liquid and the hydrogen bonding term of the fat-soluble substance, and a polarization term in the Hansen solubility parameter that is between the polarization term of the first liquid and the polarization term of the fat-soluble substance.

[0007] The substance obtained in the second mixing step contains a high concentration of the fat-soluble substance. However, since the first additive is mixed therein, even if a certain period of time has elapsed since the substance obtained in the second mixing step was formed, the possibility of crystallization of the fat-soluble substance can be reduced. Therefore, it becomes possible to produce a substance (such as an e-liquid) containing a high concentration of a fat-soluble substance without significantly changing the composition ratio of the first liquid and the second liquid. Since the composition ratio of the first liquid and the second liquid is not significantly changed, when the substance obtained in the second mixing step is used as an e-liquid of an electronic cigarette, the flavor and amount of smoke can be easily set to a desired level.

[0008] Preferably, the first additive contains at least one of triacetin, L-menthol, ethyl p-hydroxybenzoate, and butyl benzoate.

[0009] More preferably, in the first additive addition step, 4 wt% or more and 6 wt% or less of the first additive is added to the substance obtained in the second mixing step.

[0010] As the mixing method, before performing the second mixing step, an emulsifier addition step may be performed in which an emulsifier is added to a substance obtained by mixing the first liquid, the fat-soluble substance, and the first additive, and stirring is performed.

[0011] By performing the emulsifier addition step before the second mixing step, even when the fat-soluble substance is contained at a high concentration, crystallization and separation are less likely to occur.

[0012] The first mixing step and the first additive addition step may be performed simultaneously.

[0013] More preferably, the substance obtained in the second mixing step is used as an e-cigarette vape liquid. The mixing method performs a second additive input step in which a second additive is added before or after the first additive input step. The second additive is composed of a fragrance.

[0014] More preferably, a fat-soluble substance is prepared so that the concentration is 10% or more and 30% or less. The concentration is a value obtained by multiplying the content of the fat-soluble substance by 100 and dividing it by the volume of the substance obtained in the second mixing step.

[0015] More preferably, in the first additive input step, when the concentration of the fat-soluble substance is high, more first additives are added compared to when the concentration of the fat-soluble substance is low.

[0016] The e-cigarette vape liquid according to the present invention is composed of a first liquid composed of PG (propylene glycol), a fat-soluble substance composed mainly of cannabinoids containing CBD (cannabidiol), and a first additive having a hydrogen bond term in the Hansen solubility parameter between the hydrogen bond terms of the first liquid and the fat-soluble substance and a polarization term in the Hansen solubility parameter between the polarization terms of the first liquid and the fat-soluble substance, and a second liquid composed of VG (vegetable glycerin) are mixed.

[0017] The e-cigarette vape liquid according to the present invention is composed of a first liquid composed of PG (propylene glycol), a fat-soluble substance composed mainly of cannabinoids containing CBD (cannabidiol), and a first additive having a hydrogen bond term in the Hansen solubility parameter between the hydrogen bond terms of the first liquid and the fat-soluble substance and a polarization term in the Hansen solubility parameter between the polarization terms of the first liquid and the fat-soluble substance, an emulsifier, and a second liquid composed of VG (vegetable glycerin) are mixed.

[0018] The vapor liquid generation device for electronic cigarettes according to the present invention includes a first liquid composed of PG (propylene glycol), a fat-soluble substance composed of cannabinoids mainly including CBD (cannabidiol), a first additive having a hydrogen bond term in the Hansen solubility parameter that is a value between the hydrogen bond term of the first liquid and the hydrogen bond term of the fat-soluble substance, and a polarization term in the Hansen solubility parameter that is a value between the polarization term of the first liquid and the polarization term of the fat-soluble substance, a second liquid composed of VG (vegetable glycerin), a container used to mix at least the first liquid and the fat-soluble substance, and a heat transfer part used to warm the container.

Advantages of the Invention

[0019] As described above, according to the present invention, it is possible to provide a method for mixing substances in which crystals of the fat-soluble substance are less likely to precipitate.

Brief Description of the Drawings

[0020]

Figure 1

Figure 2

Figure 3

Figure 4

Modes for Carrying Out the Invention

[0021] Hereinafter, this embodiment will be described with reference to the drawings (see FIGS. 1 and 2). Note that the embodiments are not limited to the following embodiments. In principle, the content described in one embodiment is also applicable to other embodiments. In addition, each embodiment and each modification can be combined as appropriate.

[0022] (Mixing device 1) The mixing device 1 in this embodiment (a device for generating e-cigarette vape liquid) includes a container 10, a heat transfer part 20, a stirring part 30, a first liquid 41a, a second liquid 41b, a fat-soluble substance 43, a first additive 45a, and a second additive 45b (see FIG. 1). The mixing device 1 is used for generating e-cigarette vape liquid and the like.

[0023] (Container 10) The container 10 is a container for mixing materials for generating vape liquid. The container 10 is used for mixing at least the first liquid 41a and the fat-soluble substance 43.

[0024] (Heat transfer part 20) The heat transfer part 20 is a device for transferring heat to the container 10 and is used for heating the container 10 to 70°C or higher in the first mixing step described later. The heat transfer part 20 is composed of, for example, a heating device using fire. However, the heat transfer part 20 may be composed of other devices such as an electric heater.

[0025] (Stirring part 30) The stirring part 30 is composed of a stirring rod or the like and is used for stirring when mixing the first liquid 41a and the fat-soluble substance 43 put into the container 10. However, the stirring is not limited to the form using a stirring rod and may be performed by other methods. For example, the stirring part 30 may have a configuration including a stirrer device 30a and a rotor 30b.

[0026] (First liquid 41a) The first liquid 41a is composed of PG (propylene glycol).

[0027] (Second liquid 41b) The second liquid 41b is composed of VG (vegetable glycerin). For example, the first liquid 41a and the second liquid 41b are prepared so as to have a volume ratio of 3:7 or 4:6. However, this volume ratio may be other values.

[0028] (Fat-soluble substance 43) The fat-soluble substance 43 is composed mainly of cannabinoids with CBD (cannabidiol). The fat-soluble substance 43 is prepared so that its concentration is 10% or more and 30% or less. The concentration mentioned here is represented by the content (mg) of the fat-soluble substance 43 ÷ the volume (ml) of the substance (mixture of the first liquid 41a, the second liquid 41b, the fat-soluble substance 43, the first additive 45a, and the second additive 45b) after the stirring process described later × 100.

[0029] (First additive 45a) Under the condition of 25°C, the first additive 45a has a hydrogen bond term δH in the Hansen solubility parameter that is a value (9 - 10.1) between the hydrogen bond term δH of the first liquid 41a and the hydrogen bond term δH of the fat-soluble substance 43 in the Hansen solubility parameter, and the polarization term δP in the Hansen solubility parameter is a value (4.5 - 6) between the polarization term δP of the first liquid 41a and the polarization term δP of the fat-soluble substance 43 in the Hansen solubility parameter. Also, it is desirable that the first additive 45a has a dispersion term δD in the Hansen solubility parameter of a value of 16 - 18.2 under the condition of 25°C. For example, the first additive 45a contains at least one of triacetin, L-menthol, ethyl p-hydroxybenzoate, and butyl benzoate. The first additive 45a is used in an amount of 4 weight percent or more and 6 weight percent or less with respect to the substance (mixture of the first liquid 41a, the second liquid 41b, the fat-soluble substance 43, the first additive 45a, and the second additive 45b) after the stirring process described later. By setting the first additive 45a to about 4 to 6% by weight, the fat-soluble substance 43 with a concentration of about 30% can be incorporated into the mixed liquid of the first liquid 41a and the second liquid 41b without crystallization.

[0030] (Second additive 45b) The second additive 45b is composed of a fragrance.

[0031] Therefore, the vape liquid of the electronic cigarette in this embodiment is composed of at least a first liquid 41a composed of PG (propylene glycol), a second liquid 41b composed of VG (vegetable glycerin), a fat-soluble substance 43 composed of cannabinoids mainly containing CBD (cannabidiol), and a first additive 45a having a value of the hydrogen bonding term δH in the Hansen solubility parameter between the hydrogen bonding term δH of the first liquid 41a and the hydrogen bonding term δH of the fat-soluble substance 43, and having a value of the polar term δP in the Hansen solubility parameter between the polar term δP of the first liquid 41a and the polar term δP of the fat-soluble substance 43, which are mixed together.

[0032] (Mixing method) Next, the procedure of the mixing method for generating the vape liquid based on the first liquid 41a, etc. will be described (see Figure 2). First, the first liquid 41a and the fat-soluble substance 43 are put into the container 10. While being heated to 70°C or higher by the heat transfer unit 20, the substances in the container 10 are mixed using the stirring unit 30 (first mixing step S11). After the first mixing step S11, the first additive 45a is put into the container 10 (first additive input step S12). That is, the first additive 45a is added to the substances (first liquid 41a, fat-soluble substance 43) obtained in the first mixing step S11. Note that the first mixing step S11 and the first additive input step S12 may be performed simultaneously. In this case, the first liquid 41a, the fat-soluble substance 43, and the first additive 45a are put into the container 10, and while being heated to 70°C or higher by the heat transfer unit 20, the substances in the container 10 are mixed using the stirring unit 30.

[0033] Before the first additive input step S12 or after the first additive input step S12, a second additive 45b is input into the container 10 (second additive input step S13). That is, the second additive 45b is added to the substance obtained in the first mixing step S11 (first liquid 41a, fat-soluble substance 43), or to the substance obtained in the first additive input step S12 (first liquid 41a, fat-soluble substance 43, first additive 45a). However, the second additive input step S13 may be omitted. After the first additive input step S12 and the second additive input step S13, a second liquid 41b is input into the container 10, and using the stirring unit 30, the mixture inside the container 10 is stirred (second mixing step S14). That is, the second liquid 41b is added to the substance obtained in the first additive input step S12 and the second additive input step S13 (first liquid 41a, fat-soluble substance 43, first additive 45a, second additive 45b), and using the stirring unit 30, it is stirred. By the second mixing step S14, a vape liquid containing the fat-soluble substance 43 is generated. Note that the first additive input step S12, the second additive input step S13, and the second mixing step S14 may be performed in a state heated by the heat transfer unit 20, or may be performed in a non-heated state. Also, the second additive input step S13 may be performed after the second mixing step S14.

[0034] (Effect of mixing the first additive 45a) The hydrogen bond term δH in the Hansen solubility parameter of the mixed solution (the first mixed solution) of the first liquid 41a and the second liquid 41b without adding the first additive 45a such as triacetin shows a value between the hydrogen bond term δH in the Hansen solubility parameter of the first liquid 41a and the hydrogen bond term δH in the Hansen solubility parameter of the second liquid 41b. That is, the hydrogen bond term δH in the Hansen solubility parameter of the first mixed solution shows a value higher than the hydrogen bond term δH in the Hansen solubility parameter of the first liquid 41a composed of PG (propylene glycol). On the other hand, the hydrogen bond term δH in the Hansen solubility parameter of the fat-soluble substance 43 shows a value lower than the hydrogen bond term δH in the Hansen solubility parameter of the first liquid 41a composed of PG (propylene glycol).

[0035] Also, the polar term δP in the Hansen solubility parameter of the first mixed solution shows a value between the polar term δP in the Hansen solubility parameter of the first liquid 41a and the polar term δP in the Hansen solubility parameter of the second liquid 41b. That is, the polar term δP in the Hansen solubility parameter of the first mixed solution shows a value higher than the polar term δP in the Hansen solubility parameter of the first liquid 41a composed of PG (propylene glycol). On the other hand, the polar term δP in the Hansen solubility parameter of the fat-soluble substance 43 shows a value lower than the polar term δP in the Hansen solubility parameter of the first liquid 41a composed of PG (propylene glycol).

[0036] Therefore, even if the fat-soluble substance 43 is dissolved in the first mixed solution, crystallization is likely to occur.

[0037] The mixed solution (second mixed solution) of the first liquid 41a and the second liquid 41b with the first additive 45a such as triacetin added shows lower values of the hydrogen bonding term δH and the polarization term δP in the Hansen solubility parameter compared to the first mixed solution. In particular, when the content ratio (weight percentage) of the first additive 45a is increased, the hydrogen bonding term δH and the polarization term δP in the Hansen solubility parameter of the second mixed solution show low values, that is, values close to the hydrogen bonding term δH and the polarization term δP in the Hansen solubility parameter of the fat-soluble substance 43. Therefore, compared with the form in which the fat-soluble substance 43 is dissolved in the first mixed solution, even when the fat-soluble substance 43 is dissolved in the second mixed solution, crystallization is less likely to occur.

[0038] The vape liquid contains a high concentration (10% or more) of the fat-soluble substance 43, but due to the mixing of the first additive 45a, the possibility of the fat-soluble substance 43 crystallizing can be reduced even after a certain period of time has passed since the vape liquid was produced. Therefore, it becomes possible to produce a vape liquid containing a high concentration of the fat-soluble substance 43 without significantly changing the composition ratio of the first liquid 41a and the second liquid 41b. Since the composition ratio of the first liquid 41a and the second liquid 41b is not significantly changed, the flavor and amount of smoke when the vape liquid is used in an e-cigarette can be easily set to the desired level.

[0039] When the concentration of the fat-soluble substance 43 is high, it is necessary to make the composition of the second mixed solution closer to the composition of the fat-soluble substance 43 compared to when the concentration of the fat-soluble substance 43 is low. Therefore, when the concentration of the fat-soluble substance 43 is high, it is desirable to increase the content ratio of the first additive 45a (add more of the first additive 45a) compared to when the concentration of the fat-soluble substance 43 is low.

[0040] (Application example of the mixing method) An emulsifier input step S15 of inputting an emulsifier 47 such as a sucrose ester may be performed at a stage prior to the second mixing step S14. For example, the following forms can be considered (see FIGS. 3 and 4). The first mixing step S11 and the first additive input step S12 are performed simultaneously. That is, the first liquid 41a, the fat-soluble substance 43, and the first additive 45a are put into the container 10 and mixed in a state heated to 70°C or higher. Then, in the emulsifier input step S15, 4 to 6% by weight of the emulsifier 47 is added, and stirring is performed until the emulsifier 47 is completely dissolved. Thereafter, the second mixing step S14 is performed, and stirring is performed at a rotational speed of 1000 to 1500 rpm using the stirring unit 30 including the stirrer device 30a. Then, the second additive input step S13 is performed.

[0041] (Effect of adding the emulsifier input step S15) By performing the emulsifier input step S15 before the second mixing step S14, even when the fat-soluble substance 43 is contained at a high concentration (for example, 30% by weight), crystallization and separation are less likely to occur.

[0042] Although some embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the gist of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalent scope thereof.

Explanation of reference numerals

[0043] 1 Mixing device (device for generating e-cigarette vape liquid) 10 Container 20 Heat transfer section 30 Stirring section 30a Stirrer device 30b Rotor 41a First liquid 41b Second liquid 43 Fat-soluble substance 45a First additive 45b Second additive 47 Emulsifier S11 First mixing step S12 First Additive Input Step S13 Second Additive Input Step S14 Second Mixing Step

Claims

1. A first mixing step of mixing a first liquid and a fat-soluble substance in a state heated to 70°C or higher; A first additive input step in which a first additive is added to the first liquid and the fat-soluble substance; A mixing method for performing a second mixing step in which a second liquid is added to the substance obtained by mixing the first liquid, the fat-soluble substance, and the first additive and stirring is performed, The first liquid is composed of PG (propylene glycol), The second liquid is composed of VG (vegetable glycerin), The fat-soluble substance is composed of cannabinoids mainly including CBD (cannabidiol), The first additive has a value of the hydrogen bond term in the Hansen solubility parameter between the hydrogen bond term of the first liquid and the hydrogen bond term of the fat-soluble substance, and the polarization term in the Hansen solubility parameter has a value between the polarization term of the first liquid and the polarization term of the fat-soluble substance. Mixing method.

2. The mixing method according to claim 1, wherein the first additive includes at least one of triacetin, L-menthol, ethyl p-hydroxybenzoate, and butyl benzoate.

3. In the first additive input step, the first additive is input in an amount of 4 wt% or more and 6 wt% or less with respect to the substance obtained in the second mixing step. The mixing method according to claim 1 or claim 2.

4. Before performing the second mixing step, an emulsifier input step is performed in which an emulsifier is added to the substance obtained by mixing the first liquid, the fat-soluble substance, and the first additive and stirring is performed. The mixing method according to any one of claims 1 to 3.

5. The mixing method according to any one of claims 1 to 4, wherein the first mixing step and the first additive input step are performed simultaneously.

6. The substance obtained in the second mixing step is used as an e-cigarette vape liquid, The mixing method performs a second additive input step in which a second additive is added before or after the first additive input step, The mixing method according to any one of claims 1 to 5, wherein the second additive is composed of a fragrance.

7. The fat-soluble substance is prepared so that the concentration is 10% or more and 30% or less, The concentration is a value obtained by multiplying 100 by the content of the fat-soluble substance divided by the volume of the substance obtained in the second mixing step. The mixing method according to any one of claims 1 to 6.

8. In the first additive addition step, when the concentration of the fat-soluble substance is high, more first additives are added than when the concentration of the fat-soluble substance is low. The mixing method according to any one of claims 1 to 7.

9. A first liquid composed of PG (propylene glycol), A fat-soluble substance composed mainly of cannabinoids containing CBD (cannabidiol), A first additive having a value of the hydrogen bonding term in the Hansen solubility parameter between the hydrogen bonding term of the first liquid and the hydrogen bonding term of the fat-soluble substance, and the polarization term in the Hansen solubility parameter having a value between the polarization term of the first liquid and the polarization term of the fat-soluble substance, A vape liquid for electronic cigarettes, which is composed of a mixture of a second liquid composed of VG (vegetable glycerin).

10. A first liquid composed of PG (propylene glycol), A fat-soluble substance composed mainly of cannabinoids containing CBD (cannabidiol), A first additive having a value of the hydrogen bonding term in the Hansen solubility parameter between the hydrogen bonding term of the first liquid and the hydrogen bonding term of the fat-soluble substance, and the polarization term in the Hansen solubility parameter having a value between the polarization term of the first liquid and the polarization term of the fat-soluble substance, An emulsifier, A vape liquid for electronic cigarettes, which is composed of a mixture of a second liquid composed of VG (vegetable glycerin).

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