Supplements for beauty and improving disease symptoms

Abstract

To provide a supplement that can be taken orally, is highly safe, has no risk of causing a side effect, and has an excellent effect on removing wrinkles and blemishes, whitening, improving atopic dermatitis, and improving cold symptoms, and that is inexpensive and easy to manufacture.SOLUTION: Each component such as propolis powder, amino acid (L-cystine powder, L-arginine, L-tryptophan, etc.), biotin powder, maltitol, citric acid, fragrance, pullulan, etc. was measured and mixed so as to have a predetermined blending ratio. Thereafter, the mixed composition was measured to a predetermined amount and solidified by applying a pressure to make a tablet-type supplement.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a supplement (health food) that can be taken orally and has effects such as reducing wrinkles and blemishes on the skin, whitening the skin, and improving cold symptoms. [Background technology]

[0002] As skin care lotions for preventing facial skin aging and achieving wrinkle and blemish removal and whitening effects, those containing antioxidants such as vitamin C, vitamin E, SOD (superoxide dismutase), and catalase, anti-inflammatory agents such as glycyrrhizinic acid, various ultraviolet absorbers, cell activating components such as α-hydroxycarboxylic acid, placenta extract, and γ-amino-β-hydroxybutyric acid, extracellular matrix components such as collagen, elastin, and hyaluronic acid, moisturizers such as urea, and those containing physiologically active components, as in Patent Document 1, have been proposed.

[0003] Meanwhile, health foods that have medicinal effects for treating and improving skin conditions such as blemishes, freckles, wrinkles, and atopic dermatitis have been developed, consisting of alcohol extracts of plants such as Japanese angelica, Miyama angelica, Angelica keiskei, Aloe arborescens, Hypericum perforatum, Houttuynia cordata, mulberry, Balsam pumila, Red jasmine, and Loquat (Patent Document 2). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2009-120521 [Patent Document 2] Japanese Patent Application Publication No. 10-295325 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the above-mentioned conventional skin care lotions do not necessarily have sufficient effects on wrinkles, age spots, or whitening, and if used in large amounts to achieve sufficient wrinkle, age spots, or whitening effects, they can cause strong irritation to the skin and, in some cases, can even cause inflammation.On the other hand, it is difficult to say that conventional health foods such as those described in Patent Document 2 above are sufficiently effective in treating skin age spots, wrinkles, and skin diseases such as atopic dermatitis.

[0006] The object of the present invention is to provide a supplement that can be taken orally, that overcomes the problems of the above-mentioned conventional skin care lotions and supplements, that is highly safe and does not pose any risk of inducing side effects, that has excellent effects in removing wrinkles and blemishes, whitening effects, improving atopic dermatitis, and improving cold symptoms, and that can be produced inexpensively and easily. [Means for solving the problem]

[0007] Among the present inventions, the invention described in claim 1 is a method for producing a medicament for the treatment of ulcerative colitis, comprising at least propolis, amino acids and biotin. The amino acids contained in the supplement are L-cystine, L-arginine, L-tryptophan, L-methionine, L-lysine hydrochloride, and L-threonine, and the amount of biotin contained in the propolis is 0.1% or more but less than 0.2%. It is characterized by the following.

[0008] The invention described in claim 2 is the invention described in claim 1, The amino acid is formulated so that the daily intake is 1,000 mg or more and less than 7,000 mg, the propolis is formulated so that the daily intake is 80 mg or more and less than 900 mg, and the biotin is formulated so that the daily intake is 0.1 mg or more and less than 0.5 mg. It is characterized by the following.

[0009] The invention described in claim 3 is characterized in that, in the invention described in claim 1 or claim 2, the amount of biotin mixed with the propolis is 0.1% or more and less than 0.2%. [Effects of the Invention]

[0010] The supplement according to the present invention can be produced inexpensively and easily, and has the effects of reducing skin blemishes, removing wrinkles, whitening the skin, and improving the symptoms of atopic dermatitis in people of a wide range of ages, regardless of gender.The supplement according to the present invention also has the effect of improving the symptoms of colds and influenza in people of a wide range of ages, regardless of gender. DETAILED DESCRIPTION OF THE INVENTION

[0011] An embodiment of the supplement according to the present invention will be described in detail below. In the following description, the symbol "~" used in relation to the content or amount of each ingredient generally means that the value on the left is equal to or greater than the value on the right and less than the value on the right.

[0012] The supplement of the present invention is characterized by containing at least propolis, amino acids, and biotin. The amino acids to be contained in the supplement of the present invention are preferably L-type amino acids from 21 types of amino acids: alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and GABA (γ-aminobutyric acid), or derivatives thereof such as hydrochlorides and sulfates.

[0013] Among these amino acids, the use of one or a mixture of two or more of cystine, arginine, tryptophan, or their derivatives is preferred, since a small amount can be used to achieve high wrinkle and blemish removal effects, skin beautifying and whitening effects, etc. Furthermore, the use of a mixture of cystine, arginine, and tryptophan is even more preferred, since it achieves extremely high wrinkle and blemish removal effects, skin beautifying and whitening effects, and the use of a mixture of cystine, arginine, tryptophan, lysine (L-lysine) or their hydrochlorides, threonine, and methionine is particularly preferred, since it achieves extremely high wrinkle and blemish removal effects, skin beautifying and whitening effects, etc.

[0014] The supplement of the present invention preferably contains 1,000 to 7,000 mg of the above amino acids (and / or their derivatives) as a total daily intake equivalent, more preferably 2,000 to 6,000 mg, and particularly preferably 2,500 to 4,000 mg. If the amount of amino acids (equivalent to the daily intake) is less than 1,000 mg, the synergistic effect with propolis and biotin is not obtained, and sufficient effects such as wrinkle and blemish removal, skin beautification, and whitening are not obtained, which is undesirable. However, if the amount of amino acids (equivalent to the daily intake) exceeds 7,000 mg, it is uneconomical and may cause severe skin irritation, which is undesirable.

[0015] The propolis contained in the supplement of the present invention is a sticky substance secreted by plants that bees collect and use to build their nests, commonly known as bee tar. The supplement of the present invention preferably contains 80 to 900 mg of propolis, equivalent to a daily intake of 80 to 900 mg of solids, and more preferably 150 to 500 mg of solids. It is also preferable to use a powder with a solids concentration of 40 to 60% by mass (obtained by drying and solidifying an ethanol extract solution) as the propolis, as this facilitates tableting under pressure.

[0016] Furthermore, the supplement of the present invention must contain biotin. Biotin is vitamin B7, a water-soluble vitamin classified as a B vitamin. Biotin extracted from beans, egg yolk, yeast, etc. can be suitably used. The supplement of the present invention is believed to exhibit excellent effects on removing blemishes and wrinkles, whitening the skin, and improving the symptoms of atopic dermatitis and colds, due to the synergistic effect of biotin and the propolis.

[0017] The supplement of the present invention preferably contains 0.1 to 0.5 mg of biotin, and more preferably 0.3 to 0.5 mg of biotin, calculated as a solid content equivalent to the daily intake. Furthermore, it is preferable to use a powder of an extract (a mixture with lactose hydrate, starch, cellulose, etc.) with a concentration of 1 to 3% by mass as the biotin, since this facilitates tableting under pressure.

[0018] On the other hand, the ratio of biotin to propolis (pure component) in the supplement of the present invention is not particularly limited, but if the ratio is adjusted to 0.07 to 0.35% by mass, the interaction between propolis and biotin will be significant, and greater effects on removing blemishes and wrinkles from the skin, whitening effects, and improving symptoms of atopic dermatitis and colds will be obtained, so this is preferable, and a ratio of 0.10 to 0.20% by mass is even more preferable.

[0019] Furthermore, in addition to the essential ingredients of propolis, amino acids, and biotin, the supplement of the present invention can contain ingredients commonly used in supplements, such as preservatives, UV absorbers, antioxidants, sweeteners, and flavorings, as needed. [Example]

[0020] The supplements according to the present invention will be described in more detail below with reference to examples, but the present invention is not limited to the embodiments of the examples, and can be appropriately modified within the scope of the present invention. In addition, the evaluation methods of the physical properties and characteristics in the examples are as follows.

[0021] <Wrinkle and blemish removal effects> The subjects (3 people) were asked to take the supplements prepared in each example and comparative example for a certain period of time (once a day for 14 days), and then the condition of the facial skin of each subject was subjected to a sensory evaluation using the following 4-point scale (the average score (◎, ○, △, ×) of the evaluation results of the 3 subjects was used as the final evaluation result). ○: Sufficient reduction effect is observed on wrinkles around the eyes and forehead and skin blemishes. △: A slight reduction in wrinkles around the eyes and forehead and skin blemishes is observed. ×: Almost no reduction effect was observed on wrinkles around the eyes and forehead or skin blemishes.

[0022] <Whitening effect> After taking the supplements for a certain period of time as described above, the subjects (3 people) were given a sensory evaluation of the changes in facial skin color using the following 4-point scale (the average of the evaluation results of the 3 subjects (○, △, ×) was used as the final evaluation result). ○: Sufficient whitening is observed on the skin of the entire face. △: Slight whitening of the skin over the entire face. ×: No whitening was observed on the skin of the entire face.

[0023] <Improvement of atopic dermatitis> The supplements of each example and comparative example were taken by subjects (10 people) with atopic dermatitis for a certain period of time (once a day for 14 days), and then a questionnaire was administered to determine whether or not there was any improvement in the symptoms of atopic dermatitis. The number of subjects who answered that there was an improvement was used to evaluate the supplements on a four-point scale as follows: ◎: 6 or more subjects responded that there was an improvement effect ○: 4 or 5 subjects responded that there was an improvement effect △: 2 or 3 subjects responded that there was an improvement effect ×: 1 or 0 subjects responded that there was an improvement effect

[0024] <Improving cold symptoms> The supplements of each example and each comparative example were taken (once a day) by subjects (10 subjects) who had developed cold symptoms. After recovery, they were asked to survey whether or not the supplements had improved their cold symptoms. The number of subjects who answered that they had improved their cold symptoms was used to evaluate the supplements on a four-point scale as follows: ◎: 6 or more subjects responded that there was an improvement effect ○: 4 or 5 subjects responded that there was an improvement effect △: 2 or 3 subjects responded that there was an improvement effect ×: 1 or 0 subjects responded that there was an improvement effect

[0025] [Example 1] <Preparation of supplements> The following components were thoroughly mixed and dried to obtain a mixed composition.

[0026] <Supplement ingredients> Propolis powder (solid concentration 50% by mass): 11.1 parts by mass ·amino acid L-cystine powder (solid concentration per 100 parts by weight): 18.5 parts by weight L-arginine (solid concentration 100 parts by mass): 18.5 parts by mass L-tryptophan (solid concentration per 100 parts by weight): 18.5 parts by weight Biotin powder (solid concentration: approximately 1.0 part by weight, mixture with lactose hydrate, corn starch, crystalline cellulose, etc.): 0.89 parts by weight Maltitol: 9.63 parts by weight Citric acid: 15.6 parts by weight ·Fragrance: 4.4 parts by mass Pullulan: 1.1 parts by weight Other sweeteners: 1.7 parts by weight

[0027] Thereafter, the mixed composition was weighed to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Example 1. The blending amounts of each component of the obtained supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 600mg (solid propolis: 300mg) ·amino acid L-cystine: 1,000mg L-arginine: 1,000mg L-tryptophan: 1,000mg Biotin powder: 48 mg (solid biotin: 0.48 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners (aspartame, etc.): 92mg

[0028] The obtained supplement of Example 1 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the above-mentioned methods. The evaluation results are shown in Table 1 together with the composition of the supplement.

[0029] [Example 2] <Preparation of supplements> A mixed composition was obtained in the same manner as in Example 1, except that the blending ratio of the amino acid components was changed as follows. ·amino acid L-cystine powder (solid concentration per 100 parts by weight): 18.5 parts by weight L-arginine (solid concentration 100 parts by mass): 13.0 parts by mass L-tryptophan (solid concentration per 100 parts by weight): 5.6 parts by weight L-methionine (solid concentration per 100 parts by weight): 18.5 parts by weight

[0030] The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Example 2. The amounts of each ingredient in the resulting supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 600mg (solid propolis: 300mg) ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-methionine: 1,000mg Biotin powder: 48 mg (solid biotin: 0.48 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 92mg

[0031] The obtained supplement of Example 2 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the methods described above. The evaluation results are shown in Table 1, along with the composition of the supplement.

[0032] [Example 3] <Preparation of supplements> A mixed composition was obtained in the same manner as in Example 1, except that the blending ratio of the amino acid components was changed as follows. ·amino acid L-cystine powder (solid concentration per 100 parts by weight): 18.5 parts by weight L-arginine (solid concentration 100 parts by mass): 13.0 parts by mass L-tryptophan (solid concentration per 100 parts by weight): 5.6 parts by weight L-methionine (solid concentration per 100 parts by weight): 14.8 parts by weight L-Lysine hydrochloride (solid concentration per 100 parts by weight): 1.9 parts by weight ·L-threonine (solid concentration 100 parts by mass): 1.9 parts by mass

[0033] The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Example 3. The amounts of each ingredient in the resulting supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 600mg (solid propolis: 300mg) ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-methionine: 1,000mg L-lysine hydrochloride: 100mg L-Threonine: 100mg Biotin powder: 48 mg (solid biotin: 0.48 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 92mg

[0034] The obtained supplement of Example 3 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the above-mentioned methods. The evaluation results are shown in Table 1 together with the composition of the supplement.

[0035] [Example 4] <Preparation of supplements> A mixed composition was obtained in the same manner as in Example 1, except that the blending ratio of the amino acid components was changed as follows. ·amino acid L-cystine powder (solid concentration per 100 parts by weight): 18.5 parts by weight L-arginine (solid concentration 100 parts by mass): 13.0 parts by mass L-tryptophan (solid concentration per 100 parts by weight): 5.6 parts by weight L-methionine (solid concentration per 100 parts by weight): 9.3 parts by weight L-Lysine hydrochloride (solid concentration per 100 parts by weight): 4.6 parts by weight ·L-threonine (solid content concentration 100 parts by mass): 4.6 parts by mass

[0036] The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Example 4. The amounts of each ingredient in the resulting supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 600mg (solid propolis: 300mg) ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-Methionine: 500mg L-lysine hydrochloride: 250mg L-Threonine: 250mg Biotin powder: 48 mg (solid biotin: 0.48 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 92mg

[0037] The obtained supplement of Example 4 was then evaluated for its "wrinkle removal and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the above-mentioned methods. The evaluation results are shown in Table 1 together with the composition of the supplement.

[0038] [Example 5] <Preparation of supplements> A mixed composition was obtained in the same manner as in Example 1, except that the blending ratio of biotin powder was changed as follows. Biotin powder (solid concentration: approximately 1.0 part by weight, mixture with lactose hydrate, corn starch, crystalline cellulose, etc.): 0.45 parts by weight

[0039] The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Example 5. The amounts of each ingredient in the resulting supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 600mg (solid propolis: 300mg) ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-Methionine: 500mg L-lysine hydrochloride: 250mg L-Threonine: 250mg Biotin powder: 24 mg (solid biotin: 0.24 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 116mg

[0040] The obtained supplement of Example 5 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the methods described above. The evaluation results are shown in Table 1, along with the composition of the supplement.

[0041] [Example 6] <Preparation of supplements> Mixed compositions were obtained in the same manner as in Example 1, except that the blending ratio of propolis powder was changed as follows: Propolis powder (solid concentration 50 parts by weight): 7.4 parts by weight

[0042] The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Example 6. The amounts of each ingredient in the resulting supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 400mg (solid propolis: 200mg) ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-Methionine: 500mg L-lysine hydrochloride: 250mg L-Threonine: 250mg Biotin powder: 48 mg (solid biotin: 0.48 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 292mg

[0043] The obtained supplement of Example 6 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the methods described above. The evaluation results are shown in Table 1, along with the composition of the supplement.

[0044] <Comparative Example 1> <Preparation of supplements> A mixed composition was obtained in the same manner as in Example 2, except that propolis powder was not added when mixing the components. The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Comparative Example 1. The blending amounts of each component of the obtained supplement (corresponding to the daily intake amount) are as follows: ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-methionine: 1,000mg Biotin powder: 48 mg (solid biotin: 0.48 mg) Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 92mg

[0045] The obtained supplement of Comparative Example 1 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the methods described above. The evaluation results are shown in Table 1, along with the composition of the supplement.

[0046] <Comparative Example 1> <Preparation of supplements> A mixed composition was obtained in the same manner as in Example 2, except that biotin powder was not added when mixing the components. The mixed composition was then weighed out to a fixed amount (5.4 g) and compressed to form tablets of the supplement of Comparative Example 2. The blending amounts of each component of the obtained supplement (corresponding to the daily intake amount) are as follows: Propolis powder: 600mg (solid propolis: 300mg) ·amino acid L-cystine: 1,000mg L-arginine: 700mg L-tryptophan: 300mg L-methionine: 1,000mg Maltitol: 520mg Citric acid: 840mg ·Fragrance: 240mg Pullulan: 60mg Other sweeteners: 92mg

[0047] The obtained supplement of Comparative Example 2 was then evaluated for its "wrinkle and blemish removal effect," "skin whitening effect," "atopic dermatitis improvement effect," and "cold symptom improvement effect" using the methods described above. The evaluation results are shown in Table 1, along with the composition of the supplement.

[0048] [Table 1]

[0049] Table 1 shows that the supplements of Examples 1 to 6, which contain propolis, amino acids, and biotin, are effective in removing blemishes and wrinkles from the skin, whitening the skin, and improving atopic dermatitis. It can also be seen that the supplements of Examples 1 to 6 are effective in improving cold symptoms. In contrast, the supplement of Comparative Example 1, which does not contain propolis, and the supplement of Comparative Example 2, which does not contain biotin, did not provide effective skin removal of blemishes and wrinkles, whitening the skin, improving atopic dermatitis, or improving cold symptoms. [Industrial Applicability]

[0050] Since the supplement of the present invention has the excellent effects as described above, it can be suitably used as a supplementary food for reducing wrinkles and blemishes on the skin, whitening the skin, improving atopic dermatitis, ameliorating cold symptoms, etc.

Claims

1. A supplement containing at least propolis, amino acids, and biotin, The amino acids include L-cystine, L-arginine, L-tryptophan, L-methionine, L-lysine hydrochloride, and L-threonine; A supplement characterized in that the amount of biotin contained in the propolis is 0.1% or more but less than 0.2%.

2. The amino acid is formulated so that the daily intake is 1,000 mg or more but less than 7,000 mg, and The propolis is formulated so that the daily intake amount is 80 mg or more but less than 900 mg, and 2. The supplement according to claim 1, characterized in that it is formulated so that the daily intake of biotin is 0.1 mg or more but less than 0.5 mg.

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