Method and system for selectively coupling a blood sampling pressure device

Abstract

Selective coupling of a bladder and a bucket of a blood separation system includes mating an integrated connector of the bladder with a receiver disposed within the bucket without disassembling the bucket from the blood separation system. The receiver has a locking receptacle and is attached to a portion of the bucket. The integrated connector of the bladder selectively engages with the receiver. When engaged, the connector locks into the receiver via a locking latch. To remove the bladder from the bucket, an operator releases the locking latch and removes the bladder from the bucket without disassembling the bucket and bladder. The engagement and disengagement are accomplished with a quick interconnection motion. The integrated connector and receiver are valveless and do not impede a fluid flow path from a fluid source to the bladder.

Description

[Technical Field]

[0001] (CROSS-REFERENCE TO RELATED APPLICATIONS) This application claims priority to U.S. Patent Application No. 17 / 975,180, filed October 27, 2022, which claims the benefit of U.S. Provisional Patent Application No. 63 / 280,049, filed November 16, 2021. The entire disclosure of the above application is incorporated herein by reference.

[0002] This section provides background information related to the present disclosure that is not necessarily prior art.

[0003] FIELD OF THE DISCLOSURE The present disclosure relates generally to blood separation systems, and more particularly to the attachment of pressure bladders to centrifuge buckets in blood separation systems. [Background technology]

[0004] Blood collection and processing plays a critical role in the global healthcare system. In traditional large-scale blood collection, blood is withdrawn from a donor or patient, separated into various blood components by centrifugation, filtration, or elutriation, and stored in sterile containers for infusion into the patient for therapeutic applications. The separated blood components typically include fractions including red blood cells, white blood cells, platelets, and plasma. Separation into blood components can be performed continuously during collection or, particularly for processing of whole blood samples, after collection in batches. Separation of blood into its various components under highly sterile conditions is important for many therapeutic applications. Summary of the Invention [Problem to be solved by the invention]

[0005] This section provides a general overview of the disclosure and is not an exhaustive disclosure of the entire scope or all features. [Means for solving the problem]

[0006] At least one exemplary embodiment relates to a selective coupling assembly. The selective coupling assembly includes a bucket, a bladder, and a connector. The bucket has a wall and a receiver. The wall extends from an open end of the bucket to a closed end of the bucket. The wall at least partially defines a cavity between the open end and the closed end. The receiver is attached to the wall. The receiver has a body and a latch plate. The body has a receptacle and a receiver lumen extending between a first side of the body and a second side of the body. The receiver lumen has a lumen axis. The latch plate is slidably attached to the body. The latch plate has an opening, with an opening axis parallel to the lumen axis. The bladder has a sealed expandable chamber and a fluid port communicating from an interior volume of the sealed expandable chamber to the outside of the bladder. The connector is attached to the bladder. At least a portion of the connector is within the fluid port. The connector has a base and a plug. The plug protrudes from the base. The connector has a connector lumen formed in the base and the plug. The connector lumen provides a fluid flow path from the interior volume of the sealed expandable chamber to the exterior of the bladder.

[0007] In at least one exemplary embodiment, at least a portion of the receptacle is within the wall.

[0008] In at least one exemplary embodiment, the plug further includes a recess and a groove, the recess being spaced a first distance from the base of the plug, the groove being formed around the periphery of the plug, and the groove being spaced a second distance from the base of the plug.

[0009] In at least one exemplary embodiment, the connector further includes an O-ring at least partially disposed within the groove.

[0010] In at least one exemplary embodiment, the connector comprises a plastic material and is attached to the bladder via at least one weld.

[0011] In at least one exemplary embodiment, the connector is configured to move between an engaged state with the receiver and an unlocked state with the receiver, wherein in the engaged state the bladder is coupled to the bucket and in the unlocked state the bladder is separated from the bucket.

[0012] In at least one exemplary embodiment, in the locked state, the plug is at least partially disposed within the receptacle and a portion of the latch plate is within the recess of the plug.

[0013] In at least one exemplary embodiment, in the locked state, a fluid flow path is between the interior volume of the sealed expandable chamber and the receiver lumen of the receiver, the fluid flow path being unobstructed by a valve between the bladder and the receiver.

[0014] At least one exemplary embodiment relates to a bladder assembly comprising a flexible member and a connector. The flexible member has a sealed expandable chamber. The flexible member has a fluid port communicating from an interior volume of the sealed expandable chamber to an exterior of the sealed expandable chamber. The connector is attached to the flexible member and is at least partially within the fluid port. The connector has a base and a plug. The plug protrudes from the base. The connector defines a connector lumen that passes through the base and the plug. The connector lumen provides a fluid flow path from the interior volume of the sealed expandable chamber to an exterior of the flexible member.

[0015] In at least one exemplary embodiment, the connector is attached to the flexible member via a seal that surrounds the fluid port and joins a portion of the flexible member to the base of the connector.

[0016] At least one example embodiment relates to a method of coupling a bladder to a bucket, the method comprising inserting a bladder having an integrated connector into a hollow portion of the bucket, the method further comprising aligning the integrated connector with a receptacle in a wall of the bucket, the method further comprising moving the integrated connector into the receptacle, and the method further comprising applying a force to the integrated connector to engage a latch of the receptacle with a portion of the integrated connector to reduce or prevent axial movement of the integrated connector relative to the receptacle.

[0017] In at least one exemplary embodiment, moving the integrated connector into the receiver includes inserting a selective coupling tool into the hollow portion of the bucket, moving the integrated connector into the receiver further includes moving the selective coupling tool into contact with a portion of the integrated connector, and moving the integrated connector into the receiver further includes manipulating the selective coupling tool to move the integrated connector toward the receiver.

[0018] In at least one exemplary embodiment, moving the selective coupling tool into contact with a portion of the integrated connector includes positioning the selective coupling tool relative to a top surface of the bucket, and further including aligning indicia on a shaft of the selective coupling tool with a reference point on the top surface of the bucket.

[0019] In at least one exemplary embodiment, the bladder has a sealed expandable chamber and a fluid port leading from an interior volume of the sealed expandable chamber to the exterior of the bladder.

[0020] In at least one exemplary embodiment, the integrated connector includes a base and a plug, the plug protruding from the base, and a connector lumen passing through the base and the plug, the connector lumen providing a fluid flow path from the interior volume of the sealed expandable chamber to the exterior of the bladder.

[0021] At least one example embodiment relates to a method for separating a bladder from a bucket, the method comprising inserting a selective coupling tool at least partially into a hollow portion of the bucket in an area between the bladder and a wall of the bucket. The method further comprises engaging the selective coupling tool with a latch plate of a receptacle at least partially residing in the wall of the bucket. The method further comprises moving the selective coupling tool to move the latch plate from a locked state to an unlocked state. In the locked state, a portion of the latch plate is engaged with a portion of a connector of the bladder. In the unlocked state, the portion of the latch plate is disengaged from the portion of the connector of the bladder. The method further comprises moving the connector away from the receptacle to separate the bladder from the bucket.

[0022] In at least one exemplary embodiment, the engaging step includes aligning a pin of the selective coupling tool with a corresponding hole formed in the latch plate, and further including inserting at least a portion of the pin into the corresponding hole.

[0023] In at least one exemplary embodiment, the aligning step includes aligning indicia on a shaft of the selective coupling tool with a reference point on a top surface of the bucket.

[0024] In at least one exemplary embodiment, the engaging step includes contacting the selective coupling tool with a flange of the latch plate.

[0025] At least one exemplary embodiment relates to a selective coupling tool. The selective coupling tool includes a shaft and a bifurcated extension. The shaft extends from a proximal end to a distal end. The bifurcated extension protrudes from the distal end. The bifurcated extension has a first side and a second side opposite the first side. The bifurcated extension includes a cradle and a protrusion. The cradle has a contact surface between the first side and the second side. The protrusion is on the second side.

[0026] In at least one exemplary embodiment, the protrusion is a frustoconical protrusion.

[0027] In at least one exemplary embodiment, the protrusion is a plate.

[0028] In at least one exemplary embodiment, the selective coupling tool further comprises a handle and indicia, the handle connected to the proximal end of the shaft, the indicia being on the shaft.

[0029] In at least one exemplary embodiment, the indicia are etched into a portion of the shaft, and the indicia extend around at least a portion of the outer surface of the shaft.

[0030] At least one exemplary embodiment relates to a blood separation device. The blood separation device includes a rotor, a bucket, a receiver, a bladder, and a connector. The bucket is attached to the rotor. The bucket includes a wall and a receiver. The wall extends from an open end of the bucket to a closed end of the bucket. The wall defines a cavity between the open end and the closed end. The receiver is attached to the wall. The receiver has a body and a latch plate. The body has a receptacle and a receiver lumen extending between a first side of the body and a second side of the body. The receiver lumen has a lumen axis. The latch plate is slidably attached to the body. The latch plate has an opening, with an opening axis parallel to the lumen axis. The bladder has a sealed expandable chamber and a fluid port extending between an interior volume of the sealed expandable chamber and the outside of the bladder. The connector is attached to the bladder, at least a portion of the connector is within the fluid port, the connector has a base, a plug, and a connector lumen, the plug protrudes from the base, the connector lumen passes through the base and the plug, and the connector lumen provides a fluid flow path from the interior volume of the sealed expandable chamber to the outside of the bladder.

[0031] At least one exemplary embodiment relates to a selective coupling assembly. The selective coupling assembly includes a receiver, a bladder, and a connector. At least a portion of the receiver is within a wall of a bladder holder. The receiver includes a body and a latch plate. The body includes a receptacle and a first lumen extending from a first side of the body to a second side of the body. The first lumen has a lumen axis. The latch plate is slidably attached to the body. The latch plate has an opening with an opening axis parallel to the lumen axis. The bladder includes an expandable chamber and a fluid port communicating from an interior volume of the expandable chamber to the outside of the bladder. The connector is attached to the bladder. At least a portion of the connector is within the fluid port. The connector includes a base and a plug. The plug protrudes from the base. The connector defines a connector lumen through the base and the plug. The connector lumen provides a fluid flow path from the interior volume of the expandable chamber to the exterior of the bladder.

[0032] In at least one exemplary embodiment, the bladder is configured to be moved from a first position outside the bladder holder to a second position inside the bladder holder, and the receiver is at least partially within the bladder holder.

[0033] In at least one exemplary embodiment, the connector is configured to be moved between an locked state with the receiver and an unlocked state with the receiver, wherein the locked state couples the bladder to the bladder holder, and the unlocked state separates the bladder from the bladder holder, and the connector is configured to be moved between the locked and unlocked states from an interior region of the bladder holder.

[0034] In at least one exemplary embodiment, the connector is configured to be moved between the locked and unlocked states without the use of a tool.

[0035] In at least one exemplary embodiment, the connector is configured to be moved between the locked and unlocked states by inserting a tool into the region from outside the bladder holder.

[0036] In at least one exemplary embodiment, the bladder holder is a bucket of a separation device, and the wall extends from an open end of the bucket to a closed end of the bucket.

[0037] At least one exemplary embodiment relates to an interconnect assembly. The interconnect assembly includes a receiver and a connector. The receiver has a body and a latch plate. The body has a receptacle and a receiver cavity extending between a first side of the body and a second side of the body. The receiver has a cavity with a cavity axis. The latch plate is slidably attached to the body. The latch plate has an opening with an opening axis parallel to the cavity axis. The connector has a base and a plug. The plug protrudes from the base. The connector defines a connector cavity through the base and the plug.

[0038] In at least one exemplary embodiment, the interconnect assembly further includes a bladder having an expandable chamber and a fluid port communicating from an interior volume of the expandable chamber to an exterior of the bladder, and the connector is operably attached to the fluid port such that the connector lumen provides a fluid flow path from the interior volume of the expandable chamber to an exterior of the bladder.

[0039] In at least one exemplary embodiment, the plug further includes a recess and a flexible portion. The recess is spaced a first distance from the base of the plug. The flexible portion is disposed around the periphery of the plug. The flexible portion is configured to form a seal between the plug and the receptacle. The flexible portion is spaced a second distance from the base.

[0040] In at least one exemplary embodiment, the flexible portion is a resiliently flexible ridge that projects from the plug.

[0041] A blood separation system can be used to automate the process of blood componentization. In at least one exemplary embodiment, this process is performed by loading blood bags into a metal bucket and rotating it about an axis of rotation to separate the blood into components. Once separated, the various components may be squeezed out of the bucket by forcing fluid within the blood bag using a bladder (e.g., inflatable, pneumatic, hydraulic, etc.) also located inside the bucket (e.g., positioned adjacent to and in contact with the outside of the blood bag). These bladders must be replaced as part of routine scheduled maintenance for the blood separation system. To replace a bladder, a maintenance technician must completely remove each bucket from the blood separation system to access and loosen the nuts and screws that secure the bladder within the bucket. This process is time-consuming, complicated, and poses inherent risks to the maintenance technician. This process can take several hours to complete. As can be appreciated, maintaining the system and replacing the bladders is an expensive and frustrating task for the maintenance technician.

[0042] It is to address these and other problems that the embodiments presented herein are designed.

[0043] In at least some embodiments, the present disclosure describes methods, devices, and systems for selectively coupling (e.g., attaching and / or detaching) a bladder to a bucket without requiring complete disassembly of the bucket from a blood separation system. In one example, a receiver (e.g., a locking receiver) is attached to a portion of the bucket, and a separate connector is attached to the bladder that selectively engages with the receiver. When engaged, the connector locks to the receiver via a locking latch. To disengage the bladder from the bucket, an operator can release the locking latch and remove the bladder from the bucket without disassembling the bucket and / or bladder. Engagement and disengagement can be performed in a rapid interconnection operation that takes less than one minute to complete.

[0044] A connector (e.g., a mating plug, etc.) may be attached to a bladder (e.g., an inflatable bladder, etc.). The connector may have a base and a mating plug protruding from the base. The connector may be injection molded, welded (e.g., radio frequency (RF), ultrasonic, etc.) to the bladder, or otherwise attached (e.g., glued, adhesively bonded, fused, fastened, etc.). For example, the base of the connector may be a flat sheet or planar body that is attached to the body of the bladder.

[0045] The receiver may be attached or otherwise formed during fabrication or manufacturing of the bucket and / or blood separation system. That is, the receiver is attached (or affixed) to the bucket, becoming part of the bucket or bucket assembly. The receiver of the bucket may include an opening configured to receive at least a portion of the mating connector of the bladder. In at least one exemplary embodiment, the receiver may include a spring-loaded latch and a locking latch plate. The receiver may include a receptacle or opening configured to receive at least a portion of the mating plug of the connector. In at least one exemplary embodiment, the receiver includes a spring-loaded latch having a plate disposed perpendicular to the axis of the receptacle. The plate may include an opening similar in size to the opening of the receiver. The opening of the plate may be concentrically positioned relative to the opening of the receiver when the plate is in the unlocked position. In one example, the plate is positioned such that the edge of the opening in the plate does not block the area of ​​the opening in the receiver when in the unlocked position. In either case, the plate can be shifted relative to the opening of the receptacle when the plate is in the locked position, such that the opening in the plate is eccentrically positioned relative to the opening in the receptacle, and in the locked position, the edge of the opening in the plate blocks a portion of the area of ​​the opening in the receptacle.

[0046] When the mating plug (of the bladder) is inserted into the receptacle of the receiver (of the bucket) and pushed into the trigger position, the connector presses a trigger pin that moves a spring-loaded latch and plate in the receiver from the unlocked position to the locked position, thereby engaging the plate with a receiving groove in the connector. The receiving groove may be provided around the periphery of the mating plug or a portion thereof. In one example, the receiving groove may be configured as a recess in the body of the mating plug. When engaged, at least a portion of the edge of the opening in the plate may be inserted into the recess in the body of the mating plug, preventing movement of the mating plug along the axis of the opening in the receiver and the axis of the mating plug.

[0047] When disengaging the bladder from the bucket, the engagement procedure is reversed. For example, an operator unlatches (e.g., by hand or with a tool) the spring-loaded latch, which moves the plate from the locked position to the released position so that the plate disengages from the connector's receiving groove. If configured as a recess in the body of the mating plug, disengaging the plate completely disengages the edge of the plate's opening from the recess in the body of the mating plug, allowing movement of the mating plug along the axis of the receiver's opening and the axis of the mating plug. In some examples, the spring-loaded latch holds the plate in the released position and resets the trigger pin. While in the released position, the mating plug is disengaged from the receiver and the bladder is completely separated from the bucket. As can be appreciated, the present method, apparatus, and system enable rapid replacement of bladders during maintenance operations, saving time over traditional disassembly techniques and providing a reliable interconnection that can be performed without disassembly. In particular, the methods, apparatus, and systems described herein enable rapid selective coupling (e.g., connecting and disconnecting) of bladders and buckets within a timeframe of seconds or minutes (e.g., 1-2 minutes), rather than the hours required by conventional systems (e.g., requiring complex disassembly procedures of 2 hours or more).

[0048] In at least one exemplary embodiment, the connector includes a lumen (e.g., a fluid channel or conduit) extending through the mating plug and the base. The lumen is in fluid communication with the interior volume of the bladder. The lumen is unobstructed (e.g., valveless) and provides an unobstructed, unrestricted flow path through the connector (e.g., a flow path not restricted by sealing or flow-restricting valves). Similarly, the receptacle or opening of the receiver may form a portion of a hollow channel or lumen extending through the receiver. This lumen of the receiver may be valveless and provides an unobstructed, unrestricted flow path through the receiver (e.g., a flow path not restricted by sealing or flow-restricting valves). In at least one exemplary embodiment, a fluid (e.g., pneumatic fluid, hydraulic fluid, etc., and / or a combination thereof) is transferred along the flow path to the lumen of the receiver. When the connector is engaged with the receiver, the fluid flows via the flow path through the receiver into the lumen of the connector and into the interior volume of the bladder, or vice versa. When fluid is moved into the bladder, the bladder increases in size (e.g., expands, enlarges, expands, etc.), and when fluid is moved out of the bladder (e.g., by pumping or drawing fluid out of the bladder along a flow path), the bladder decreases in size (e.g., deflates, shrinks, contracts, etc.).

[0049] Further areas of applicability will become apparent from the description provided herein. The description and specific examples in this summary are intended for purposes of illustration only and are not intended to limit the scope of the present disclosure.

[0050] The drawings herein are for purposes of illustrating selected embodiments only, not all possible embodiments, and are not intended to limit the scope of the present disclosure. [Brief explanation of the drawings]

[0051] [Figure 1] FIG. 1 is a perspective view of a rotor of a separation device according to at least one embodiment. [Figure 2]FIG. 2 is a schematic illustration of a partial diametric cross-section of the separation device of FIG. 1 according to at least one exemplary embodiment. [Figure 3] FIG. 3 is an illustration of a top view of the rotor of FIG. 1 according to at least one exemplary embodiment. [Figure 4] FIG. 4 is a schematic illustration of a cross section along a radial plane of a separation cell of the rotor of FIG. 1 according to at least one example embodiment. [Figure 5] FIG. 5 is a schematic illustration of a cross-section along a radial plane of another separation cell according to at least one exemplary embodiment. [Figure 6] FIG. 6 is a cross-sectional view of a separation device having a rotor and a single separation cell according to at least one example embodiment. [Figure 7] FIG. 7 is a partial cross-sectional view of the separation device of FIG. 6 according to at least one exemplary embodiment. [Figure 8] 8A-8C are partial cross-sectional views of the selective coupling assembly of the separation device of FIG. 6, according to at least one exemplary embodiment. FIG. 8A shows the selective coupling assembly in a released (or disengaged or unlocked) state. FIG. 8B shows the selective coupling assembly in an intermediate (or partially engaged) state. FIG. 8C shows the selective coupling assembly in a locked (or engaged) state. [Figure 9] 9A-9D illustrate a selective bonding tool according to at least one exemplary embodiment: FIG. 9A is a perspective view from a first side of the selective bonding tool; FIG. 9B is a perspective view from a second side of the selective bonding tool; FIG. 9C is a partial perspective view from the first side of the selective bonding tool; and FIG. 9D is a partial perspective view from the second side of the selective bonding tool. [Figure 10] 10 is a partial elevational view of the separation device of FIG. 6 having a selective coupling assembly guided from an unlocked state toward a locked state by the selective coupling tool of FIGS. 9A-9D, according to at least one exemplary embodiment. [Figure 11]11A-11B are views of the selective coupling assembly of FIG. 6 in a locked state, according to at least one exemplary embodiment. FIG. 11A is a perspective view of a connector (shown in dotted lines) and a receiver of the selective coupling assembly. FIG. 11B is a perspective view of the receiver. [Figure 12] 12A-12B are views of the selective coupling assembly of FIG. 11A in a locked state before being unlocked by the selective coupling tool of FIGS. 9A-9D, according to at least one exemplary embodiment. FIG. 12A is a perspective view of the selective coupling assembly in a locked state with the tool engaged with a portion of the receiver. FIG. 12B is a perspective view of the tool engaged with a portion of the receiver in a locked state. [Figure 13] FIG. 13 is a perspective view of the selective coupling assembly of FIG. 12A in a disengaged state with the selective coupling tool of FIGS. 9A-9B engaged with a portion of a receiver, according to at least one exemplary embodiment. [Figure 14] 14A-14B are cross-sectional views of another selective coupling assembly having a mating plug and a receiver, according to at least one exemplary embodiment, with Fig. 14A showing the mating plug engaged with the receiver and Fig. 14B showing the mating plug disengaged from the receiver. [Figure 15] 15A-15B are cross-sectional views of yet another selective coupling assembly having a mating plug and a receiver, according to at least one exemplary embodiment, with Fig. 15A showing the mating plug engaged with the receiver and Fig. 15B showing the mating plug disengaged from the receiver. [Figure 16] 16A-16B are cross-sectional views of yet another selective coupling assembly having a mating plug and a receiver, according to at least one exemplary embodiment, with Fig. 16A showing the mating plug engaged with the receiver and Fig. 16B showing the mating plug disengaged from the receiver. [Figure 17]17A-17D illustrate another selective bonding tool, according to at least one exemplary embodiment: FIG. 17A is a perspective view from a first side of the selective bonding tool; FIG. 17B is a perspective view from a second side of the selective bonding tool; FIG. 17C is a partial perspective view from the first side of the selective bonding tool; and FIG. 17D is a partial perspective view from the second side of the selective bonding tool. [Figure 18] 18A-18B are diagrams relating to unlocking the selective coupling assembly using the tool of FIGS. 17A-17D , according to at least one exemplary embodiment. FIG. 18A is a perspective view of the selective coupling assembly in a locked state. FIG. 18B is a perspective view of the selective coupling assembly in a locked state with the tool engaged with the selective coupling assembly prior to being moved to an unlocked state. [Figure 19] 19A-19B are schematic partial cross-sectional views of another separation device having a channel for facilitating use of a selective coupling tool, according to at least one exemplary embodiment. Fig. 19A shows the selective coupling assembly with the tool partially within the channel. Fig. 19B shows the selective coupling assembly with the tool within the channel and in contact with a receiver on the selective coupling assembly. [Figure 20] FIG. 20 is a flowchart of a method for engaging a bladder with a separation cell of a separation device according to an embodiment of the present disclosure. [Figure 21] FIG. 21 is a flowchart of a method for disengaging a bladder from a separation cell of a separation device according to an embodiment of the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0052] Corresponding reference characters indicate corresponding parts shown in the several views of the drawings.

[0053] Exemplary embodiments will be described in more detail with reference to the accompanying drawings.

[0054] The exemplary embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope to those skilled in the art. Numerous specific details are set forth, such as examples of specific components, devices, and methods, to provide a thorough understanding of the embodiments of the present disclosure. It will be apparent to those skilled in the art that specific details are not necessary, that the exemplary embodiments can be embodied in many different forms, and that none of these should be construed as limiting the scope of the present disclosure. In some exemplary embodiments, well-known processes, well-known device structures, and well-known technologies are not described in detail.

[0055] The terminology used herein is for the purpose of describing particular exemplary embodiments only and is not intended to be limiting. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms unless the context clearly dictates otherwise. The terms "comprises," "comprising," "including," and "having" are inclusive and thus specify the presence of stated features, entities, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. The method steps, processes, and operations described herein should not be construed as necessarily requiring performance in the particular order described or illustrated, unless specifically identified as such. It should also be understood that additional or alternative steps may be employed.

[0056] When an element or layer is referred to as "on," "engaged with," "connected to," or "coupled to" another element or layer, it may be directly on, directly engaged with, directly connected to, or directly coupled to the other element or layer, or intervening elements or layers may be present. Conversely, when an element is referred to as "directly on," "directly engaged with," "directly connected to," or "directly coupled to" another element or layer, there are no intervening elements or layers present. Other terms used to describe relationships between elements should be interpreted similarly (e.g., "between" vs. "directly between," "adjacent" vs. "directly adjacent," etc.). As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0057] Terms such as "first," "second," and "third" may be used herein to describe various elements, components, regions, layers, and / or sections, but these elements, components, regions, layers, and / or sections should not be limited by these terms. These terms are used only to distinguish one element, component, region, layer, or section from another region, layer, or section. Terms such as "first," "second," and other numerical terms, when used herein, do not imply a sequence or order unless clearly indicated by context. Thus, a first element, first component, first region, first layer, or first section described below could also be referred to as a second element, second component, second region, second layer, or second section without departing from the teachings of the exemplary embodiments.

[0058] Spatial terms such as "inside," "outside," "beneath," "below," "lower," "upper," and "above" are used herein for ease of description when describing the relationship of one element or feature to another element(s) or feature(s), as shown in the figures. Spatial terms may be intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures were inverted, elements described as being "beneath" or "beneath" other elements or features would correspondingly change to "above" the other elements or features. Thus, for example, the term "below" can encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees to another orientation), and the spatial descriptions used herein should be interpreted accordingly.

[0059] At least one embodiment of the present disclosure relates to an apparatus for separating separate volumes of a complex liquid (e.g., blood) in parallel (or simultaneously) by centrifugation, the apparatus comprising: a centrifuge configured to receive a plurality of separation bags, each containing a different volume of the complex liquid; component transfer means for transferring at least one separated component from each separation bag to a satellite bag connected to the separation bag; first balancing means for initially balancing the rotor if the weights of the four separation bags are different; and second balancing means for balancing the rotor if the weight of the separated components transferred to the satellite bags causes the rotor to become unbalanced.

[0060] 1 illustrates a rotor 100 of a separation device (e.g., centrifuge 200 of FIG. 2) according to at least one exemplary embodiment. Rotor 100 generally includes one or more (e.g., four as shown) separation cells 102. In at least one exemplary embodiment, separation cells 102 are identical to one another. Each separation cell 102 includes a container 104 (also interchangeably referred to herein as a "bucket"). Each of containers 104 may have the general shape of a rectangular parallelepiped.

[0061] Each of the separation cells 102 may further include a lid 106. In at least one exemplary embodiment, the lid 106 is a hinged side lid. In at least one exemplary embodiment, the lid 106 comprises an upper portion of the outer wall of the container 104. The lid 106 is dimensioned such that, when open, a liquid-filled (or full) separation bag (e.g., separation bag 400 in FIGS. 4-5 ) can be easily loaded into the separation cell 102. The container 104 may include a fastening and locking means (not shown) that allows the lid 106 to be fastened or locked to the rest of the container 104.

[0062] In at least one exemplary embodiment, each separation cell 102 further includes first and second pinch valves 108, 110 (collectively referred to as a "pair of pinch valves 108, 110").

[0063] Rotor 100 may further include a storage means, such as a central vessel 120. In at least one exemplary embodiment, central vessel 120 is subdivided into multiple satellite vessels 122, as shown. Satellite vessels 122 may be arranged around a central cavity 124.

[0064] Rotor 100 may further include a turntable 130. In at least one exemplary embodiment, turntable 130 has a frusto-conical shape. Rotor 100 may further include a manifold 132. Manifold 132 may have a generally circular shape or a generally circular arrangement. In at least one exemplary embodiment, manifold 132 is disposed near a periphery 134 of turntable 130. In at least one exemplary embodiment, manifold 132 forms a ring within turntable 130e (not shown). In at least one exemplary embodiment, manifold 132 is referred to as a "peripheral circular manifold."

[0065] 2 , in at least one exemplary embodiment, rotor 100 is part of a separation device such as a centrifuge 200. Rotor 100 is supported by bearing assemblies 202 to facilitate rotation of rotor 100 about a first axis or axis of rotation 204. Rotor 100 includes a cylindrical rotor shaft 206 extending along a second axis or shaft longitudinal axis 208. A pulley 210 is connected to rotor shaft 206. Central vessel 120 is connected to an upper end 212 of rotor shaft 206. Thus, shaft longitudinal axis 208 coincides with both rotation axis 204 and a third longitudinal axis or vessel longitudinal axis 214 of central vessel 120.

[0066] In at least one exemplary embodiment, the turntable 130 flares below the opening of the central vessel 120. The separation cells 102 are mounted on the turntable 130 in a symmetrical arrangement about the axis of rotation 204.

[0067] In at least one exemplary embodiment, centrifuge 200 further includes a motor 220. Motor 220 may be coupled to rotor 100 by a belt 222. Belt 222 may be engaged in a groove 224 of pulley 210 to facilitate rotation of rotor 100 about axis of rotation 204 by motor 220.

[0068] Each separation cell 102 has a central longitudinal axis 226. In at least one exemplary embodiment, the separation cells 102 are mounted on the turntable 130 such that their respective central longitudinal axes 226 intersect the rotation axis 204 and are positioned at approximately the same distance from the rotation axis 204 and / or such that the angles between the central longitudinal axes 226 of the separation cells are approximately the same (e.g., about 90 degrees). The positions of the separation cells 102 on the turntable 130 may be adjusted to balance the rotor 100, for example, to evenly distribute weight on the turntable when the separation cells 102 are empty. In at least one exemplary embodiment, the separation cells 102 are inclined relative to the rotation axis 204 at an acute angle equal to the angle of the frustum geometrically defining the turntable 130.

[0069] Each container 104 defines a hollow portion 230. In at least one exemplary embodiment, the hollow portion 230 is sized and shaped to loosely accommodate a separation bag (e.g., separation bag 400 of FIGS. 4-5) containing (or filled with) a liquid. The hollow portion 230 (also referred to herein as a "separation compartment 230") is defined by a bottom wall located farthest from the rotation axis 204, a lower wall closest to the turntable 130, an upper wall opposite the lower wall, and two side walls.

[0070] In at least one exemplary embodiment, cavity portion 230 includes a main portion extending from a bottom wall and having a generally rectangular parallelepiped shape with rounded corners, and an upper portion having a generally prism shape with a triangular base that converges to a point. Thus, the upper portion of cavity portion 230 is defined by two pairs of opposing walls that converge toward central longitudinal axis 226 at the center of cavity portion 230. In at least one exemplary embodiment, this design may facilitate radial expansion of a thin layer of small components of a complex fluid (e.g., platelets in whole blood) after separation by centrifugation, making the small components more easily detectable at the top of the separation bag (e.g., separation bag 400 of FIGS. 4-5).

[0071] Centrifuge 200 further includes a component transfer means for transferring at least one separated component from each separation bag (e.g., separation bag 400 of FIGS. 4-5) to a connected satellite bag (e.g., satellite bag 502 of FIG. 5). The component transfer means, in at least one exemplary embodiment, can include a squeezing system for squeezing the separation bag in separation compartment 230 and transferring the separated component into the satellite bag, as described in more detail below.

[0072] In at least one exemplary embodiment, the squeezing system includes a flexible partition 232 (also interchangeably referred to herein as a "bladder") selectively coupled to each of the containers 104 to define an expandable chamber 234 within the hollow portion thereof. More specifically, the flexible partition 232 is dimensioned to line the bottom wall of the hollow portion 230 and at least a portion (e.g., a majority) of the lower wall of the hollow portion 230 closest to the turntable 130. Each container 104 can include a respective flexible partition 232.

[0073] In at least one exemplary embodiment, the squeezing system further includes a manifold 132. Each of the expandable chambers 234 is fluidly connected to the manifold 132 by a supply channel 236 that penetrates the wall of the respective vessel 104 near the bottom of the vessel.

[0074] In at least one exemplary embodiment, the squeezing system further includes a hydraulic pumping station 240. The hydraulic pumping station 240 may be configured to pump hydraulic fluid into and / or out of each of the expandable chambers 234 in the separation cells 102. The hydraulic fluid is selected to have a density slightly higher than the densest component of the complex liquid being separated (e.g., red blood cells if the complex liquid is blood). As a result, during centrifugation, the hydraulic fluid in each expandable chamber 234, whatever its volume, generally remains in the outermost portion of each separation cell 102. In at least one exemplary embodiment, the hydraulic pumping station 240 is connected to each of the expandable chambers 234 by ducts 244 via rotary seals or fluid couplings 242. The ducts pass through the rotor shaft 206, the bottom and sidewalls of the central vessel 120, and radially from the rim of the central vessel 120, through the turntable 130, and connect to the manifold 132.

[0075] In at least one exemplary embodiment, hydraulic pump station 240 includes a piston pump having a piston 246 movable within a hydraulic cylinder 248 fluidly connected to a duct 244 via a rotating seal 242. Piston 246 may be actuated by a stepper motor 250 that moves a lead screw 252 coupled to a rod of piston 246. Hydraulic cylinder 248 is also connected to a hydraulic fluid reservoir 254. Hydraulic fluid reservoir 254 may have a path controlled by a valve 256. Valve 256 may be configured to selectively allow hydraulic fluid to be introduced into or withdrawn from a hydraulic circuit that includes hydraulic cylinder 248, duct 244, and expandable chamber 234. In at least one exemplary embodiment, a pressure gauge 258 is connected to the hydraulic circuit to measure the hydraulic pressure therein.

[0076] In at least one exemplary embodiment, the centrifuge 200 further includes four pairs of first and second pinch valve members 108, 110. The pairs of pinch valve members 108, 110 may be attached to the rotor 100 around the opening of the central container 120. Each pair of pinch valve members 108, 110 faces its associated separation cell 102. The pinch valve members 108, 110 may be configured to selectively block or allow the flow of liquid through a flexible plastic tube (e.g., tube 506 in FIG. 5 ) and to facilitate selective sealing and cutting of the flexible plastic tube.

[0077] Each of the pinch valve members 108, 110 includes an elongated cylindrical body and a head portion having a groove 260. The groove 260 may be defined by a fixed upper jaw (not shown) and a lower jaw (not shown) that is movable between open and closed positions. The groove 260 is sized so that tubing (e.g., tubing 506 in FIG. 5) of one or more bag sets can snugly engage the groove when the lower jaw is in the open position. The elongated body may include a mechanism (not shown) for moving the lower jaw and is connected to a radio frequency generator that provides the energy necessary to seal and cut the tubing (e.g., made of plastic).

[0078] In at least one exemplary embodiment, the pinch valve members 108, 110 are mounted inside the central vessel 120 adjacent to its inner surface with their longitudinal axes generally parallel to the axis of rotation 204 and with their heads projecting above the rim of the central vessel 120. In at least one exemplary embodiment, electrical power is supplied to the pinch valve members 108, 110 through a slip ring array 270 mounted around the bottom of the rotor shaft 206.

[0079] In at least one exemplary embodiment, centrifuge 200 further includes a first balancing means for initially balancing rotor 100 when separation bags (e.g., separation bag 400 of FIGS. 4-5) included in separation cell 102 have different weights. The first balancing means includes substantially the same components as the elements of the component transfer means described above, namely, four expandable hydraulic chambers (e.g., similar to hydraulic chamber 234) interconnected by a manifold (e.g., similar to manifold 132), and a hydraulic pumping station (e.g., similar to hydraulic pumping station 240) for pumping hydraulic fluid into the hydraulic chambers through ducts (e.g., similar to duct 244) connected to the manifold. To initially balance the rotor 100, whose four separation cells 102 contain four respective volumes of composite liquids that do not have the same weight (because the four volumes are unequal and / or the liquid densities vary slightly for each volume), the hydraulic pumping station is controlled to pump a predetermined volume of hydraulic fluid into the interconnected hydraulic chambers at the start of the separation process, selected to balance the rotor 100 in the most unbalanced situation. For whole blood, determining this balancing volume takes into account the maximum difference in volume between two donations and the maximum difference in hematocrit (i.e., density) between the two donations. Under centrifugal force, the hydraulic fluid is distributed unevenly among the four separation cells 102 according to the difference in weight of the separation bags, balancing the rotor 100. To achieve a desired or optimal initial balance, the volume of the hollow portion 230 of the separation cell 102 may be selected so that the hollow portion 230 does not become full after a determined amount of hydraulic fluid is pumped into the interconnected expandable chambers 234, regardless of the volume of the separation bag contained therein.

[0080] In at least one exemplary embodiment, the centrifuge 200 further includes a second balancing means for balancing the rotor 100 when the weights of components transferred to satellite bags (e.g., satellite bag 502 in FIG. 5 ) in the central container 120 are different. For example, if two blood donations have the same hematocrit but different volumes, the volume of plasma extracted from each donation will be different, and the same is true when two blood donations have the same volume but different hematocrit. In at least one exemplary embodiment, the second balancing means includes four flexible rectangular pouches 280 interconnected by four tubing sections (not shown). Each tubing section connects two adjacent pouches 280 at the bottom. The pouches 280 contain a volume of balancing liquid having a density close to that of the composite liquid. The volume of balancing liquid is selected to balance the rotor 100 in its most unbalanced state. The four pouches 280 are sized to cover the inner surface of the central container 120 and to have an internal volume larger than the volume of the balancing liquid so that the balancing liquid can spread freely within the pouches 280. In operation, for example, if four satellite bags (e.g., satellite bags 502 in FIG. 5 ) adjacent to the four pouches 280 receive different volumes of plasma components, the four satellite bags will be subjected to centrifugal force and pressed unevenly against the four pouches 280, resulting in the balancing liquid being unevenly distributed within the four pouches 280 to compensate for the weight differences within the satellite bags.

[0081] In at least one exemplary embodiment, the centrifuge further includes a controller 290 including a control unit (e.g., a microprocessor, a controller, etc.) and memory (e.g., a computer-readable memory, etc.) for providing the microprocessor with information and programmed instructions regarding various separation protocols (e.g., a protocol for separating plasma and blood cell components, or a protocol for separating plasma, platelet, and red blood cell components) and the operation of the device in accordance with such separation protocols. In particular, the microprocessor is programmed to receive information regarding centrifugation speeds at which the rotor 100 should be rotated during various stages of the separation process (e.g., a component separation stage, a plasma expression stage, a platelet suspension in the plasma fraction stage, a platelet expression stage, etc.), and information regarding various transfer flow rates at which the separated components should be transferred from a separation bag (e.g., separation bag 400 in FIGS. 4-5 ) to a satellite bag (e.g., satellite bag 502 in FIG. 5 ). Information regarding the various transfer flow rates may be expressed, for example, as hydraulic fluid flow rates in the hydraulic circuit or as the rotational speed of the stepper motor 250 of the hydraulic pump station 240. The microprocessor may be further programmed to receive information from the pressure gauge 258 and from the four pairs of sensors 310, 312, either directly or via memory, and to control the centrifuge motor 220, the stepper motor 250 of the hydraulic pump station 240, and the four pairs of pinch valve members 108, 110 to operate the separation apparatus in accordance with a selected separation protocol.

[0082] 3, in at least one exemplary embodiment, the top of each separation cell 102 includes walls 300 that converge toward a respective central longitudinal axis 226. In at least one exemplary embodiment, walls 300 converge toward a plurality of channels 302 (e.g., three as shown) that open at the top of vessel 104. Channels 302 may be cylindrical channels. Channels 302 may extend generally parallel to one another.

[0083] In at least one exemplary embodiment, the centrifuge 200 further includes four pairs of sensors for monitoring the separation of various components occurring within each separation bag as the device operates. Each sensor pair includes a first sensor, i.e., bag sensor 310, and a second sensor, i.e., tube sensor 312. The sensors 310, 312 may be embedded in the lid 106 of the container 104 of each separation cell 102. The sensors 310, 312 may be mounted along the central longitudinal axis 226 of the container 104. The bag sensor 310 may be located farther from the axis of rotation 204 than the tube sensor 312. In at least one exemplary embodiment, when a separation bag (e.g., separation bag 400 in FIGS. 4-5) is placed in the container 104 and the lid 106 is closed, the bag sensor 310 faces the upper triangular portion of the separation bag, and the tube sensor 312 faces the proximal end of the tube (e.g., tube 506 in FIG. 5). Bag sensor 310 may be configured to detect blood cells in the liquid. Tube sensor 312 may be configured to detect the presence or absence of liquid in the tube as well as detect blood cells in the liquid. Each of sensors 310, 312 may include a photocell including an infrared LED and a photodetector. In at least one exemplary embodiment, power is provided to sensors 310, 312 through slip ring array 270 ( FIG. 2 ) mounted around a lower portion of rotor shaft 206 ( FIG. 2 ).

[0084] As shown in FIG. 4 , each container 104 may be configured to house a respective separation bag 400. The containers 104 may have fastening means for fastening the separation bag 400 within the separation cell 102. In at least one exemplary embodiment, the fastening means includes one or more (e.g., two as shown) pins 410 and one or more corresponding recesses 412. The pins 410 may protrude from an inner surface 414 of the lid 106 near a top 416 of the separation cell 102. The recesses 412 may be formed in an inner surface 418 of the container 104. The pins 410 may be spaced apart and sized to be received in one or more holes 420 in an upper edge (e.g., two upper corners) of the separation bag 400.

[0085] In at least one exemplary embodiment, centrifuge 200 (FIG. 2) is configured for use with bag set 500. As shown in FIG. 5, bag set 500 includes separation bag 400 and multiple satellite bags 502. Separation bag 400 and satellite bags 502 may be flexible. In at least one exemplary embodiment, separation bag 400 is used sequentially for collection independent or remote from centrifuge 200 and then for separation within centrifuge 200. Satellite bags 502 may be used within centrifuge 200 to receive separated components.

[0086] In at least one exemplary embodiment, the separation bag 400 is connected to tubing (not shown), which may optionally have a needle (not shown) at its distal end for blood donation. The satellite bag 502 may be connected to the separation bag 400 by tubing 506 and, optionally, a breakable stopper (not shown) between the separation bag 400 and the satellite bag 502. Pinch valve members 108, 110 (FIGS. 1-3) are disposed in each of the tubing 506 leading to the satellite bag 502.

[0087] In at least one exemplary embodiment, as shown in FIG. 5 , the separation cell 102′ includes a container 104′ for the separation bag 400 integrated with a satellite bag container 510. The separation cell 102′ and container 104′ are the same as the separation cell 102 and container 104 of FIGS. 1-3 unless otherwise noted below. The satellite bag container 510 defines a satellite cavity 512 having a rectangular parallelepiped shape. The satellite cavity 512 may be configured to accommodate one of the pouches 280 of the balancing assembly described above. The separation bag container 104′ is overlaid on the satellite bag container 510 such that the openings of both containers 104′, 510 are coplanar and facing the axis of rotation 204 (FIGS. 2-3) when the containers are attached to the turntable 130 (FIGS. 1-3).

[0088] In at least one exemplary embodiment, the bag set 500 includes a separation bag 400 for receiving a separate volume of whole blood from a donor and two satellite bags 502. The first satellite bag is configured to receive plasma and platelet components from the whole blood, and the second satellite bag is configured to receive a red blood cell component of the whole blood. In at least one other exemplary embodiment, the bag set 500 includes a separation bag 400 for receiving a separate volume of whole blood from a donor and three satellite bags 502. The first satellite bag is configured to receive the plasma component of the whole blood, the second satellite bag is configured to receive the platelet component of the whole blood, and the third satellite bag is configured to receive the red blood cell component of the whole blood. In at least one other exemplary embodiment, the plurality of satellite bags 502 includes more than three satellite bags. The bag set 500 may include a three-way connector on the tubing between the separation bag 400 and a portion of the satellite bag 502. When the separation bag 400 is in the container 104', the tubing 506 extends through each channel 302. One or more of the satellite bags 502 may be fluidly connected to a filter 520, such as a leukoreduction filter.

[0089] While described with reference to at least one arrangement of a separation cell 102 of a centrifuge 200, it should be understood that embodiments of the selective coupling assemblies described herein may be utilized in any fluid processing, separation, and / or analysis system and are not limited to the separation apparatus described herein. Additionally or alternatively, embodiments of the present disclosure may be employed for any coupling between components within a bucket or within any partially enclosed volume with limited access. For example, a bucket may include a deep container portion, i.e., a hollow portion that is accessible only on one side, has a small cross-sectional area, a narrow width or length, or has a limited volume. In some examples, a bucket may be sized such that an operator cannot reach the hollow portion and reach the bottom wall of the bucket. In either case, the selective coupling assemblies described herein are used to quickly couple one component to another within a bucket with limited volume and space.

[0090] Figure 6 illustrates a separator apparatus 600 according to at least one exemplary embodiment. Separator apparatus 600 is the same as separator apparatus 200 of Figure 2, except for the presence of an optional coupling assembly, described below, that couples the bladder to the bucket.

[0091] In at least one exemplary embodiment, separation apparatus 600 includes a rotor 602 and at least one separation cell 604 (e.g., as shown, a single separation cell 604). Separation cell 604 includes buckets 606 (also referred to as containers or bladder holders). As described above, buckets 606 of separation cell 604 are positioned at an angle relative to an axis of rotation 608 of rotor 602. Separation apparatus 600 includes a selective coupling assembly 620 (also referred to as a "quick connector," "QC connector," or "interconnect assembly"). Selective coupling assembly 620 includes a connector 622 and a receiver 624. In at least one exemplary embodiment, connector 622 is associated with a flexible bulkhead or bladder 626, and receiver 624 is associated with bucket 606.

[0092] As shown in FIG. 7 , receiver 624 of selective coupling assembly 620 may be attached to at least one wall 700 of bucket 606. In at least one exemplary embodiment, receiver 624 is at least partially within bucket wall 700. Receiver 624 may be disposed adjacent to bottom wall 702 of bucket 606. Receiver 624 may be made from a polymer (e.g., plastic), a metal, or any combination thereof. In at least one exemplary embodiment, the metal of receiver 624 includes aluminum, steel, titanium, or any combination thereof. Receiver 624 includes a locking member, a lumen therethrough, and / or one or more external seals, as described in more detail below.

[0093] As shown, connector 622 is attached to bladder 626. In at least one exemplary embodiment, connector 622 includes a body 704 having a flat base 706 and a mating plug 708 extending from flat base 706. Connector 622 has or defines a first lumen 710 therethrough.

[0094] Connector 622 may be formed from or attached to bladder 626. For example, flat base 706 of connector 622 may be welded (e.g., ultrasonically) and / or adhesively bonded to bladder 626. In at least one exemplary embodiment, the connected portions are formed from a polymer (e.g., a plastic material).

[0095] In at least one exemplary embodiment, the flat base 706 of the connector 622 is sandwiched between and attached to the inner and outer walls or layers of the bladder 626. For example, the wall 712 of the bladder 626 corresponds to a laminate having one or more layers. In this case, holes are formed through the layers, and the flat base 706 is between two or more layers of the laminate. The layers of the laminate may be attached to the flat base 706 by adhesive bonding, fusion bonding, and / or welding using RF or ultrasound. Once attached, the interior volume of the bladder 626 is sealed from the exterior of the bladder 626 by contact at the periphery of the flat base 706. However, the first lumen 710 may pass through the mating plug 708 to provide a fluid flow path 720 into the interior volume of the bladder 626 within a defined space.

[0096] When connected to receiver 624, fluid flow path 720 is formed between a fluid source (e.g., a liquid supply or a gas supply) and the interior volume of bladder 626. Fluid flow path 720 is unobstructed at the interconnected portions of selective coupling assembly 620. In at least one exemplary embodiment, there are no valves or seals disposed in the fluid flow path within selective coupling assembly 620. That is, fluid flow path 720 does not include valves or seals.

[0097] 8A-8C illustrate a selective coupling assembly 620 in various states of engagement and disengagement, according to at least one exemplary embodiment. The connector 622 includes an engagement plug 708 protruding from a flat base 706. The engagement plug 708 includes a first annular groove 800 (also referred to herein as an "O-ring groove 800") formed therein that at least partially receives and accommodates (or is configured to at least partially receive and accommodate) an O-ring 802. When the engagement plug 708 is engaged with the receiver 624, the O-ring 802 of the connector 622 can reduce or prevent leakage of hydraulic fluid or pneumatic gas flowing along a fluid flow path 720 (shown in FIG. 7) between the fluid source and the interior volume of the bladder 626. The engagement plug 708 may further include a locking recess 804, which is an annular groove as shown. An axial center location of the locking recess 804 is a first distance 806 from the flat base 706. The axial center point of the annular groove 800 is a second distance 808 from the flat base 706. The second distance 808 is greater than the first distance 806.

[0098] In at least one exemplary embodiment, receiver 624 generally includes a base 810 and an automatic latch assembly, such as a spring-loaded latch 812. Spring-loaded latch 812 includes a latch plate 814 and a trigger pin 818. Latch plate 814 is slidably mounted to base 810. Latch plate 814 includes a main portion 820 and a flange 822. Main portion 820 defines a receiving opening 824. Main portion 820 is configured to receive at least a portion of mating plug 708 of connector 622. Main portion 820 is further configured to receive at least a portion of trigger pin 818.

[0099] Base 810 has or defines a first receptacle or connector receptacle 826. In at least one exemplary embodiment, base 810 includes an inner annular protrusion or barb 828. Connector receptacle 826 is defined in a radial region between annular wall 830 and inner annular protrusion 828. Inner annular protrusion 828 has a second bore or receiver bore 832 formed therein. Receiving opening 824 of latch plate 814 is concentrically disposed with respect to connector receptacle 826 and second bore 832.

[0100] Base 810 further defines a second receptacle, or trigger pin receptacle 840. Trigger pin receptacle 840 receives at least a portion of trigger pin 818. A first spring 842 (e.g., a compression spring) is at least partially received within trigger pin receptacle 840. First spring 842 engages base 810 and trigger pin 818. In at least one exemplary embodiment, first spring 842 extends between a bottom wall 844 of trigger pin receptacle 840 and a bottom surface 846 of trigger pin 818. In at least one exemplary embodiment, trigger pin 818 has or defines a recess 847. Recess 847 is at least partially defined by bottom surface 846 of trigger pin 818. Recess 847 may be configured to receive a portion of first spring 842. In at least one exemplary embodiment, the first spring 842 is configured to bias the trigger pin 818 in a first or outward direction 848. The first direction 848 is generally parallel to a longitudinal axis 849 of the trigger pin 818.

[0101] In at least one exemplary embodiment, trigger pin 818 has or defines a first stepped portion or first annular groove 850 and a second portion or second annular groove 852. First annular groove 850 is formed closer to bottom surface 846 than second annular groove 852. That is, the distance between second annular groove 852 and bottom surface 846 is longer than the distance between first annular groove 850 and bottom surface 846. Trigger pin 818 has a first diameter at first annular groove 850, a second diameter at second annular groove 852, and a third diameter at outermost surface 854. The first diameter is smaller than the third diameter. The second diameter is smaller than the first diameter (and the third diameter). Trigger pin 818 has a top surface 856.

[0102] The receiver 624 further includes a second spring 860 (e.g., a compression spring). The second spring 860 engages the base 810 and the latch plate 814. The second spring 860 is positioned between the flange 822 of the latch plate 814 and an outer surface 862 of the base 810. The second spring 860 is configured to bias the latch plate 814 in a second or locking direction 864. The second direction 864 is generally perpendicular to the first direction 848.

[0103] The spring-loaded latch 812 is configured to move between a released, disengaged, or unlocked position (shown in FIG. 8A ) and a locked or engaged position (or locked or engaged state) (shown in FIG. 8C ). In the released position, the latch plate 814 is open so that the receiving opening 824 can receive the mating plug 708 of the connector 622. For example, the first annular groove 850 of the trigger pin 818 receives the first edge or pin edge 870 of the latch plate 814 in the released position. When the trigger pin 818 is moved along a line parallel to the longitudinal axis 849, the first annular groove 850 of the trigger pin 818 moves into the receiving opening 624 and the second annular groove 852 of the trigger pin 818 is positioned to coincide with the latch plate 814. Such positioning of the trigger pin 818 causes the second spring 860 to translate, slide, or otherwise move the latch plate 814 from the released position (FIG. 8A) along the second direction 864 to the latched position (FIG. 8C). After the latch plate 814 translates, a first edge 870 of the latch plate 814 is at least partially within the second annular groove 852.

[0104] 8C shows mating plug 708 of connector 622 locked into latch plate 814 of receiver 624. At least in the illustrated exemplary embodiment, this locking occurs when a second edge or locking edge 872 of latch plate 814 (as shown in FIG. 8C ) engages plug surface 874 of mating plug 708. Latch plate 814, including second edge 872, is at least partially positioned within locking recess 804 of connector 622.

[0105] FIG. 8A shows a detailed cross-sectional view of the connector 622 and receiver 624 of the selective coupling assembly 620 in a disengaged state. When coupling the connector 622 to the receiver 624, the mating plug 708 is supported or guided by a tool (e.g., tool 900 in FIGS. 9A-9D and tool 1700 in FIGS. 17A-17D ) inserted into the space between the bladder 626 and the bucket 606, as indicated by arrow 880 in FIG. 8A . Further details of the above-described guiding and alignment are described below. Among other things, the tool allows an operator to align the axis of the mating plug 708 with the axis of the connector receptacle 826 and / or the second lumen 832. However, in some instances, a tool may not be required when coupling and / or separating the connector 622 from the receiver 624. In either case, the bladder 626 is coupled or uncoupled while the bladder 626 and integrated connector 622 are positioned within a receiving volume portion of a bladder holder (e.g., a bucket, etc.) having a receiving portion 624 provided therein.

[0106] Figure 8B illustrates an intermediate or partially engaged state in which the mating plug 708 is partially within the connector receptacle 826 and the spring-loaded latch 812 is in a disengaged state. As shown in Figure 8B, the mating plug 708 of the connector 622 is brought into contact with the connector receptacle 826 of the receiver 624 such that the first lumen 710 of the connector 622 is concentric with the second lumen 832 of the receiver 624. As the bladder 626 and connector 622 move toward the receiver 624 (e.g., to a seated position), at least a portion of the bladder 626 and / or connector 622 contacts the trigger pin 818, causing the latch plate 814 to move into an engaged position with the locking recess 804 of the mating plug 708, as shown in Figure 8C. In this position, the connector 622 is prevented from moving along the axis of the first and second lumens 710, 832, and the bladder 626 is locked to the receiver 624 and bucket 606 in this position.

[0107] Once engaged, separation of the bladder 626 from the bucket 606 is accomplished by releasing the latch plate 814 of the receiver 624. Releasing the latch plate 814 may involve inserting a tool (e.g., a coupling tool) into the space between the wall 700 (shown in FIG. 7 ) on which the receiver 624 is disposed and the bladder 626, as described in more detail below. The coupling tool is then engaged with an actuation feature (e.g., a hole, slot, tab, etc.) located on the latch plate 814, and the coupling tool is moved to disengage the latch plate 814 from the recess or groove of the engagement plug. With reference to FIG. 8C , this movement corresponds to a movement direction from the upper left side to the lower right side of the figure. When the latch plate 814 is moved a certain distance in this direction, the trigger pin 818 translates toward the bladder 626, locking the latch plate 814 in the released position (shown in FIGS. 8A-8B ). The direction of movement may be a push or pull direction, depending, for example, on the placement of receiver 624 within bucket 606 and / or other design choices.

[0108] In some examples, the bladder 626 can be separated from the bucket 606 by releasing the latch plate 814 of the receiver 624 without the need for a separate tool. Releasing the latch plate 814 can include actuating the latch plate 814 of the receiver 624 such that the latch plate 814 disengages from the locking recess 804 of the engagement plug 708.

[0109] 9A-9D illustrate a tool 900 (also referred to as a "selective coupling tool") that may be used to facilitate locking and / or unlocking a connector 622 and its associated bladder 626 to a receiver 624 and its associated bucket 606 (FIG. 6). The tool 900 has a shaft 902 extending from a proximal end 904 to a distal end 906. A handle 908 is disposed at the proximal end 904 of the shaft 902. A coupling end 910 is disposed at the distal end 906 of the shaft 902.

[0110] In at least one exemplary embodiment, tool 900 includes indicia configured to indicate insertion depth into bucket 606 (shown in FIG. 6 ). In the exemplary embodiment shown, shaft 902 is provided with first indicia 912 and second indicia 914, as shown. Indicia 912, 914 are longitudinally spaced apart from one another. In at least one exemplary embodiment, first indicia 912 indicates an insertion depth for locking selective coupling assembly 620 (shown in FIG. 6 ), and second indicia 914 indicates an insertion depth for unlocking selective coupling assembly 620. In at least one exemplary embodiment, the indicia are etched into shaft 902.

[0111] In at least one exemplary embodiment, as best shown in FIG. 9C , the tool 900 includes features that facilitate locking of the selective coupling assembly 620 (shown in FIG. 6 ). The coupling end 910 of the tool 900 may include a bifurcated extension 916 that protrudes from the distal end 906 of the shaft 902. The bifurcated extension 916 may be U-shaped or horseshoe-shaped. The bifurcated extension 916 extends between a first side 918 of the coupling end 910 (shown in FIG. 9C ) and a second side 920 of the coupling end 910 (shown in FIG. 9D ).

[0112] The bifurcated extension 916 is provided with a cradle 922 configured to engage an outer surface of the mating plug 708 (shown in FIG. 7 ) of the connector 622 (shown in FIG. 7 ), as described in more detail below. The cradle 922 may include one or more arcuate contact surfaces 924 sized to match the size of the outer diameter of the mating plug 708 of the connector 622. In at least one other exemplary embodiment, the cradle includes one or more arcuate contact surfaces sized to have a diameter larger than the outer diameter of the mating plug 708 of the connector 622. The cradle 922 is used to assist the operator in moving the mating plug 708 into the receiver 624 (shown in FIG. 7 ).

[0113] In at least one exemplary embodiment, as best shown in FIG. 9D , the tool 900 may include one or more release features that engage with the latch plate 814 (shown in FIG. 8A ) to facilitate unlocking of the selective coupling assembly 620 (shown in FIG. 6 ). In at least one exemplary embodiment, the release features include one or more release pins 930 that protrude from a surface 932 of the second side 920 of the coupling end 910 of the tool 900. In at least one exemplary embodiment, the pins 930 extend generally perpendicular to the bottom surface 932 of the coupling end 910. The pins 930 are sized and shaped to engage with corresponding features (e.g., holes, slots, etc.) in the latch plate, as described in more detail below. In at least one exemplary embodiment, the release pins 930 have a frusto-conical shape.

[0114] As described above, tool 900 may be used to facilitate locking of selective coupling assembly 620 (shown in FIG. 6 ). FIG. 10 illustrates an arrangement for locking selective coupling assembly 620, according to at least one exemplary embodiment. After bladder 626 is inserted into bucket 606 (shown in FIG. 6 ), tool 900 is inserted into region or space 1000 between bladder 626 and receiver 624. Tool 900 is moved toward selective coupling assembly 620. In at least the illustrated exemplary embodiment, tool 900 is moved in second direction 864. Cradle 922 ( FIGS. 9C-9D ) of selective coupling tool 900 receives outer surface 1004 of engagement plug 708 such that arcuate contact surface 924 contacts outer surface 1004. Connector 622, along with bladder 626, is moved in a third or inward direction 1006 opposite first direction 848 (FIG. 8A) toward receiver 624. During movement in third direction 1006, tool 900 moves engagement plug 708 toward receiving opening 824 of receiver 624. Once engagement plug 708 is moved and inserted into receiving opening 824, tool 900 is removed from region 1000 and bladder 626 is pushed further in third direction 1006 into a locked or fully engaged state with receiver 624.

[0115] 11A-11B, in the locked state, the engagement plug 708 is at least partially within the receiving opening 824. The pin edge 870 of the latch plate 814 is at least partially within the second annular groove 852 (FIG. 8A) of the trigger pin 818. The locking edge 872 of the latch plate 814 is at least partially within the locking recess 804 of the engagement plug 708. This engagement axially locks the connector 622 in the receiver 624.

[0116] 11B , the trigger pin 818 is at least partially within a slot 1100 in the latch plate 814. In the illustrated exemplary embodiment, the slot 1100 is formed in the locking edge 872 such that the slot 1100 communicates with the receiving opening 824. A main portion 820 of the latch plate 814 extends between a first end 1110 and a second end 1112. The main portion 820 of the latch plate 814, including the first end 1110, is at least partially within the channel 1114 of the base 810. The first end 1110 may include an arcuate surface 1116. A flange 822 may extend from the second end 1112. The latch plate 814 has one or more release openings 1120 formed therein.

[0117] As described above, tool 900 ( FIGS. 9A-9D ) can be used to facilitate unlocking of selective coupling assembly 620. As shown in FIGS. 12A-12B , tool 900 can be moved toward selective coupling assembly 620. At least in the illustrated exemplary embodiment, tool 900 is moved in second direction 864 and inserted into region 1000 (shown in FIG. 10 ) between connector 622 and receiver 624. Tool 900 is then moved in third direction 1006 to at least partially insert pin 930 ( FIGS. 9A and 9C ) of tool 900 into release opening 1120 ( FIG. 11B ) of latch plate 814. With pin 930 within release opening 1120, tool 900 is translated in a fourth direction, or unlocking direction 1200, opposite second direction 864. Engagement of pin 930 of tool 900 with latch plate 814 causes latch plate 814 to move with tool 900 in fourth direction 1200 .

[0118] 13 shows the selective coupling assembly 620 in a released state, with the tool 900 still engaged with the latch plate 814. In the released state, the connector receptacle 826 of the base 810 is generally concentric with the receiving opening 824 of the latch plate 814. Stated differently, the plate edge 1300 is moved closer to, and overlaps or coincides with, the annular wall 830 in the base 810 of the receiver 624. In this position, the mating plug 708 of the connector 622 is moved in a first direction 848 to be removed from the receiver 624, as shown in FIG.

[0119] While connector 622 is shown having an O-ring 802 (shown in FIG. 8A ) configured to form a seal against annular wall 830 of receiver 624, it should be understood that different or additional sealing elements or features may be used to reduce or prevent leakage of hydraulic actuation fluid or pneumatic gas flowing along fluid flow path 720 (shown in FIG. 7 ) between the fluid source and the interior volume of bladder 626. For example, the mating plug may include a sealing feature and / or a compliant portion (e.g., configured as a resiliently bendable or flexible ridge) that can provide a seal (e.g., airtight, liquidtight, etc.) between the connector and receiver. In some examples, the sealing feature may be a separate component attached to, insert molded with, and / or co-molded with the mating plug. In one example, the sealing feature may be integrally formed from the material of the mating plug.

[0120] 14A-14B illustrate another selective coupling assembly 1400, according to at least one exemplary embodiment. The selective coupling assembly 1400 may be the same as the selective coupling assembly 620 of FIG. 6, except as specifically defined below. The selective coupling assembly 1400 includes a connector 1402 and a receiver 1404. The receiver 1404 has or defines a connector receptacle 1406 (FIG. 14B) configured to receive a portion of the connector 1402. The connector receptacle 1406 is at least partially defined by an annular wall 1408.

[0121] The connector 1402 includes a flat base 1420 and a mating plug 1422. The mating plug 1422 defines first and second annular grooves 1424, 1426 that at least partially receive first and second O-rings 1428, 1430. When the connector 1402 is mated with the connector receptacle 1406, first and second annular seals 1440, 1442 are formed between the annular wall 1408 and the first and second O-rings 1428, 1430, respectively.

[0122] The connector 1402 defines a first lumen, or connector lumen 1448, that extends through both the planar base 1420 and the mating plug 1422. An annular lumen surface 1450 at least partially defines the first lumen 1448. The receiver 1404 includes an inner annular protrusion or barb 1452. The inner annular protrusion 1452 protrudes into the connector receptacle 1406 and defines a second lumen 1454. When the connector 1402 is engaged with the receiver 1404, the inner annular protrusion 1452 is at least partially located within the first lumen 1448. A third annular seal 1456 is formed between the inner annular protrusion 1452 and the lumen surface 1450. Thus, the selective coupling assembly 1400 has both an inner seal (ie, the third seal 1456) and an outer seal (ie, the first and second seals 1440, 1442).

[0123] 15A-15B illustrate another selective coupling assembly 1500, according to at least one exemplary embodiment. The selective coupling assembly 1500 may be the same as the selective coupling assembly 620 of FIG. 6, except as otherwise defined below. The selective coupling assembly 1500 includes a connector 1502 and a receiving portion 1504. The receiving portion 1504 defines a connector receptacle 1506 (FIG. 15B) configured to receive a portion of the connector 1502.

[0124] The connector 1502 includes a flat base 1520 and a mating plug 1522. The connector 1502 defines a first lumen 1558 that extends through both the flat base 1520 and the mating plug 1522. The annular luminal surface 1550 at least partially defines the first lumen 1548.

[0125] The receiver 1504 includes an inner annular protrusion or barb 1552. The inner annular protrusion 1552 protrudes into the connector receptacle 1506 and defines a second lumen 1554. When the connector 1502 is engaged with the receiver 1504, the inner annular protrusion 1552 is at least partially located within the first lumen 1548. An annular seal 1556 is formed between the inner annular protrusion 1552 and the lumen surface 1550. Thus, the selective coupling assembly 1400 has only an inner seal (i.e., seal 1656).

[0126] 16A-16B illustrate another selective coupling assembly 1600, according to at least one exemplary embodiment. The selective coupling assembly 1600 may be the same as the selective coupling assembly 620 of FIG. 6, except as specifically defined below. The selective coupling assembly 1600 includes a connector 1602 and a receiver 1604. The receiver 1604 defines a connector receptacle 1606 (FIG. 16B) configured to receive a portion of the connector 1602. The connector receptacle 1606 is at least partially defined by an annular wall 1608.

[0127] The connector 1602 includes a flat base 1620 and a mating plug 1622. The mating plug 1622 has first and second annular grooves 1624, 1626 formed therein that at least partially receive first and second O-rings 1628, 1630. When the connector 1602 is mated with the connector receptacle 1606, first and second annular seals 1640, 1642 are formed between the annular wall 1608 and the first and second O-rings 1628, 1630, respectively. Thus, the selective coupling assembly 1600 has only outer seals (i.e., the first and second seals 1640, 1642).

[0128] 17A-17D illustrate a tool 1700 (also referred to as a "selective coupling tool") that may be used to facilitate locking and / or unlocking a connector and its associated bladder to a receiver and its associated bucket. The tool 1700 includes a shaft 1702 extending from a proximal end 1704 to a distal end 1706. A handle 1708 is disposed at the proximal end 1704. A coupling end 1710 is disposed at the distal end 1706 of the shaft 1702. In at least one exemplary embodiment, the tool 1700 further includes indicia (e.g., indicia 1712, 1714 in FIGS. 9A-9B ) configured to indicate insertion depth into the bucket.

[0129] In at least one exemplary embodiment, as best shown in FIG. 17C , the tool 1700 includes features that facilitate locking of the selective coupling mechanism. The coupling end 1710 of the tool 1700 may include a bifurcated extension 1720 protruding from the distal end 1706 of the shaft 1702. The bifurcated extension 1720 may be U-shaped or horseshoe-shaped. The bifurcated extension 1720 includes a cradle 1722 configured to engage the outer surface of the mating plug of the connector. The cradle 1722 may include one or more arcuate contact surfaces 1724 sized to match the outer diameter of the mating plug of the connector. In at least one other exemplary embodiment, the cradle includes one or more arcuate contact surfaces sized to have a diameter larger than the outer diameter of the mating plug of the connector. The cradle 1722 is used to assist the operator in moving the mating plug into the receiver.

[0130] 17D , the tool 1700 can include one or more release features that engage with the latch plate to facilitate unlocking of the selective coupling mechanism. In at least one exemplary embodiment, the release feature includes a protrusion, such as a transverse plate 1730, that protrudes from a surface 1732 of the coupling end 1710 of the tool 1700. In at least one exemplary embodiment, the plate 1730 extends generally perpendicular to the surface 1732 of the coupling end 1710. The plate 1730 is sized and shaped to engage a corresponding feature (e.g., a flange) on the latch plate, as described in more detail below.

[0131] As described above, tool 1700 can be used to facilitate locking and / or unlocking of the selective coupling assembly. Tool 1700 can be used in the same manner as tool 900 to facilitate locking the selective coupling assembly using cradle 1722.

[0132] 18A illustrates a receiver 624' according to at least one exemplary embodiment. Receiver 624' is the same as receiver 624 of FIG. 6 (including like features with like reference numerals), except that receiver 624' is attached to a bucket (not shown) rotated 180 degrees relative to the bucket about central axis 1800. Receiver 624' is shown in a locked position.

[0133] As shown in FIG. 18B , tool 1700 can be used to facilitate unlocking of receiver 624′. Tool 1700 is moved toward receiver 624′ until plate 1730 of tool 1700 engages flange 822 of latch plate 814. Tool 1700 is moved in fourth direction 1200, translating latch plate 814 in fourth direction 1200. As latch plate 814 translates, pin edge 870 ( FIG. 8A ) of latch plate 814 clears second annular groove 852 of trigger pin 818, which is urged in first direction 848 by first spring 842 ( FIG. 8A ). This holds latch plate 814 in the unlocked state.

[0134] In at least one exemplary embodiment, the separation device can include features, such as channels, to facilitate the use of a selective binding tool. Figures 19A-19B show a separation device 1900, in accordance with at least one exemplary embodiment. Separation device 1900 is identical to separation device 600 of Figure 6, except as otherwise defined below. Separation device includes a receptacle 624'.

[0135] In at least one exemplary embodiment, separation apparatus 1900 includes buckets 1902 that at least partially define rod translation channels 1904. Rod translation channels 1904 may include holes, grooves, openings, or other features. Rod translation channels 1904 are aligned with portions of latch plates 814. Rod translation channels 1904 may be formed in sidewalls 1906 of each bucket 1902, for example, to extend from a top of the bucket (not shown) to a location 1908 adjacent latch plate 814 of receiver 624′.

[0136] A tool rod or release rod 1920 is movable within the rod translation channel 1904. In the exemplary embodiment shown, the rod translation channel 1904 can receive at least a portion of the rod 1920 such that the rod 1920 can contact the flange 822 of the latch plate 814. The tool 1920 may be used to release the receiver 624′ as described with reference to FIGS. 18A-18B . Thus, the receiver 624′ can be released without inserting a tool into the space between the bladder 626 and the side wall 1906.

[0137] In at least one exemplary embodiment, tool 1920 remains within sidewall 1906 and is moved from a non-contacting position shown in Figure 19A to a contacting position shown in Figure 19B. Additionally or alternatively, tool 1920 is selectively received within rod translating channel 1904 (e.g., during a maintenance operation) and moved within rod translating channel 1904 until an end of tool 1920 contacts latch plate 814, as shown in Figure 19B.

[0138] 20 is a flowchart of a method 2000 for engaging a bladder with a separation cell of a separation device, according to an embodiment of the present disclosure. Method 2000 begins, in S2004, by inserting a bladder including a connector (e.g., an integrated connector) into an area between the bladder and the bucket. In at least one exemplary embodiment, S2004 is performed during initial setup of the separation device and / or during maintenance of the separation device. In at least one exemplary embodiment, the bladder is inserted such that the connector located at the bottom of the bladder is inserted first into the space of the hollow portion and then lowered until it is adjacent to a receptacle in the bucket.

[0139] Next, method 2000 proceeds to S2008, where the mating plug of the connector is aligned with the receptacle of the bucket. In at least one exemplary embodiment, a tool, such as tool 900 ( FIGS. 9A-9D ), tool 1700 ( FIGS. 17A-17D ), or tool 1920 ( FIGS. 19A-19B ), is used by the operator to assist in aligning the mating plug with the receptacle. For example, the length of the tool shaft is set so that when the mating end of the tool is inserted into the bucket and moved toward the bottom wall of the bucket, the tool's cradle is positioned approximately concentric with the receptacle's receiving opening with the tool's handle positioned adjacent the top of the bucket. In at least one exemplary embodiment, the tool shaft includes graduations, marks, or other indicia that allow the operator to determine the depth from the top of the bucket to the mating end of the tool. During S2008, the tool's cradle is supported by the cradle, contacting a portion of the outer diameter of the mating plug of the connector. When aligned, the axis of the mating plug is approximately collinear with the axis of the receiving opening (e.g., within a radius of about 3 millimeters to about 5 millimeters, as measured about the axis of the receiving opening). This step corresponds to at least the mating plug positions shown in FIGS. 8A, 10, and 13.

[0140] Once aligned with the receiver, method 2000, in S2012, moves the mating plug of the connector toward the receiver (e.g., the receiving opening) until the receiver latches and locks the mating plug in place. S2012 corresponds to the engagement of the connector with the receiver as described in FIGS. 8A-8C. In at least one exemplary embodiment, a tool is used to move the mating plug toward the receiver. For example, a selective coupling tool is moved, rotated, and / or pivoted at a handle to move a cradle of the coupling end that is in contact with the mating plug toward the receiver. In some examples, the bladder is pushed against the connector so that a trigger pin releases a latch plate and the mating plug is locked in place (e.g., as shown in at least FIGS. 8C and 11A). This pushing of the bladder may be performed by inserting a tool into the space behind the bladder and connector in the bucket and manipulating the tool to apply a force against the bladder that engages the connector with the receiver.

[0141] 21 is a flowchart of a method 2100 for disengaging a bladder from a bucket of a separation device, according to at least one embodiment. Method 2100 may be performed, for example, during a maintenance operation (such as by a worker) or a bladder replacement operation.

[0142] Method 2100 begins in S2104 by inserting a tool, such as tool 900 (FIGS. 9A-9D), tool 1700 (FIGS. 17A-17D), or tool 1920 (FIGS. 19A-19B), into the space between the bladder and the receptacle of the bucket. During this step, the bladder is connected to the receptacle, as shown in FIG. 8C. In at least one exemplary embodiment, the tool is moved within the space between the bladder and the receptacle of the bucket and / or the wall of the bucket until the mating end of the tool contacts the connector. In at least one exemplary embodiment, the tool is inserted into the bucket with the release pin facing the receptacle of the bucket.

[0143] The method 2100 then proceeds to S2108, where a tool is engaged with the latch plate of the receiver. In at least one exemplary embodiment, the tool is moved such that the release pin is at least partially inserted into the release hole of the latch plate.

[0144] In S2112, once the release pin is engaged with the latch plate, the selective coupling tool is moved in a release direction to unlock the engagement plug from the receiver, the release direction being dependent on the orientation of the receiver and latch plate within the bucket.

[0145] Once the latch plate has moved to the release position, method 2100 proceeds to S2116, where the mating plug of the connector is removed from the receptacle, physically separating the bladder from the bucket. Removing the mating plug may include moving the connector away from the receptacle. Once removed from the receptacle, the bladder and integrated connector are removed from the bucket. If part of a bladder replacement or maintenance operation, the operator may decide to insert and install a new or repaired bladder with an integrated connector, as described in connection with method 2000 of FIG. 20 . As will be appreciated, methods 2000 and 2100 are performed repeatedly throughout the life of the separation device.

[0146] Any of the steps, functions, and operations described herein may be performed continuously and automatically.

[0147] Although the flowcharts have been discussed and illustrated with respect to a particular sequence of events, it should be understood that modifications, additions, and omissions can be made to this sequence without substantially affecting the operation of the disclosed embodiments, configurations, and aspects.

[0148] Exemplary systems and methods of the present disclosure have been described in connection with a coupling between a bladder and a fluid supply. However, to avoid unnecessarily obscuring the present disclosure, the foregoing description omits certain known structures and devices. This omission should not be construed as limiting the scope of the disclosure as set forth in the claims. Specific details are set forth to provide an understanding of the present disclosure. However, it should be understood that the present disclosure may be practiced in a variety of ways other than the specific details set forth herein.

[0149] Many variations and modifications of the present disclosure may be employed: some features of the present disclosure may be provided without other features.

[0150] References herein to “one embodiment,” “embodiment,” “exemplary embodiment,” “some embodiments,” etc., mean that the described embodiment may include a particular feature, structure, or characteristic, but not all embodiments necessarily include that particular feature, structure, or characteristic. Furthermore, the above do not necessarily refer to the same embodiment. Furthermore, it should be noted that when a particular feature, structure, or characteristic is described in connection with one embodiment, the description of such feature, structure, or characteristic may apply to any other embodiment, unless otherwise noted and / or unless it will be readily apparent to one skilled in the art from the detailed description. The present disclosure, in its various embodiments, configurations, and aspects, includes components, methods, processes, systems, and / or apparatus substantially as illustrated and described herein, including various embodiments, subcombinations, and / or subsets thereof. After understanding the present disclosure, those skilled in the art will understand how to make and use the systems and methods disclosed herein. In various embodiments, configurations and / or aspects, the present disclosure includes providing apparatus and processes in the absence of items not shown and / or described herein, or in various embodiments, configurations and / or aspects thereof, including the absence of items that may have been used in previous apparatuses or processes, for example, to improve performance, ease of use, and / or reduce implementation costs.

[0151] The foregoing description of the present disclosure has been provided for purposes of illustration and description. It is not intended to limit the disclosure to the form or forms disclosed herein. For example, in the foregoing Detailed Description, various features of the present disclosure are grouped together in one or more embodiments, configurations, and / or aspects for the purpose of streamlining the disclosure. Features of the embodiments, configurations, or aspects of the present disclosure may be combined in alternative embodiments, configurations, or aspects other than those described above. This method of disclosure is not to be interpreted as reflecting an intention that the claimed disclosure requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment, configuration, or aspect. Accordingly, the following claims are hereby incorporated into this Detailed Description, with each claim standing on its own as a separate preferred embodiment of the present disclosure.

[0152] Furthermore, while the description of the present disclosure includes a description of one or more embodiments, configurations, or aspects, and certain variations and modifications, other variations, combinations, and modifications are within the scope of the present disclosure, e.g., may be within the skill and knowledge of a person skilled in the art after understanding the present disclosure. It is intended to entitle, to the extent permitted, the inclusion of other embodiments, configurations, and / or aspects that include alternative and / or equivalent structures, functions, ranges, or steps in place of those set forth in the claims, regardless of whether such alternative and / or equivalent structures, functions, ranges, or steps are disclosed herein, and without any intention to offer any patentable subject matter to the public.

[0153] An exemplary aspect relates to a selective coupling assembly comprising a bucket, a bladder, and a connector, the bucket having a sidewall extending from an open end of the bucket to a closed end of the bucket, a cavity portion disposed between the open end of the bucket and the closed end of the bucket, and a receiver attached to the sidewall, the receiver having a body and a latch plate slidably attached to the body, the body including a receiver cavity passing from a first side of the body to a second side of the body and a receiver opening disposed around the receiver cavity, the latch plate having a latch plate that is slidably attached to the body and a receiving hole extending from the opening to the latch plate. and an opening axis disposed parallel to the axis of the receiving portion lumen, the bladder having a sealed expandable chamber and a fluid port disposed in the bladder leading from an internal volume portion of the sealed expandable chamber to the outside of the bladder, the connector being attached (or affixed) to the bladder and at least partially disposed within the fluid port, the connector having a base, an engaging plug protruding from the base, and a connector lumen passing through the base and the engaging plug, the connector lumen providing a fluid flow path leading from the internal volume portion of the sealed expandable chamber to the outside of the bladder.

[0154] In any one or more of the above aspects, at least a portion of the receiver is disposed within the sidewall. In any one or more of the above aspects, the mating plug further includes at least one recess disposed a first distance from the base of the mating plug and a groove formed around the mating plug and disposed a second distance from the base of the mating plug. In any one or more of the above aspects, the connector further includes an O-ring disposed at least partially within the groove. In any one or more of the above aspects, the connector is made from a polymer (e.g., a plastic material), and the connector is attached to the bladder via at least one weld. In any one or more of the above aspects, the connector is movable between an engaged state with the receiver and an unlocked state with the receiver, wherein in the engaged state the bladder is fixedly coupled to the bucket and in the unlocked state the bladder is separated from the bucket. In any one or more of the above aspects, in the locked state, the engagement plug is at least partially disposed within the receiving opening of the receiver, and a portion of the latch plate is disposed within the at least one recess of the engagement plug. In any one or more of the above aspects, in the locked state, a fluid flow path is formed between the interior volume of the sealed expandable chamber and the receiver lumen of the receiver, the fluid flow path being unobstructed by a valve between the bladder and the receiver. In any one or more of the above aspects, the engagement plug further includes at least one recess disposed a first distance from the base of the engagement plug and a flexible portion disposed around the engagement plug, the flexible portion corresponding to a seal between the engagement plug and the receiving opening, the flexible portion being disposed a second distance from the base of the engagement plug. In any one or more of the above aspects, the flexible portion is a resiliently flexible ridge protruding from the engagement plug.

[0155] An exemplary aspect relates to a bladder assembly comprising a flexible member and a connector, the flexible member having a sealed expandable chamber and a fluid port communicating from an internal volume of the sealed expandable chamber to an outside of the sealed expandable chamber, the connector being attached (or affixed) to the flexible member and at least partially disposed within the fluid port, the connector having a base and an engaging plug protruding from the base, the connector having a connector lumen formed through the base and the engaging plug, the connector lumen providing a fluid flow path from the internal volume of the sealed expandable chamber to an outside of the flexible member.

[0156] In any one or more of the above aspects, the connector is attached (or affixed) to the flexible member via a seal that surrounds the fluid port and joins a portion of the flexible member to the base of the connector.

[0157] An exemplary aspect is a method of coupling a bladder to a bucket, the method comprising the steps of inserting a bladder including an integrated connector into a hollow portion of the bucket, aligning the integrated connector with a receiver located on a sidewall of the bucket, moving the integrated connector toward the receiver, and applying a locking force to the integrated connector to engage a latch of the receiver with a portion of the integrated connector and prevent axial movement of the integrated connector relative to the receiver.

[0158] In any one or more of the above aspects, moving the integrated connector toward the receiver includes inserting a selective coupling tool into the hollow portion of the bucket, moving the selective coupling tool to contact a portion of the integrated connector, and manipulating the selective coupling tool to move the integrated connector toward the receiver. In any one or more of the above aspects, moving the selective coupling tool to contact a portion of the integrated connector includes positioning the selective coupling tool relative to a top surface of the bucket and aligning a scale on a shaft of the selective coupling tool with a reference point on the top surface of the bucket. In any one or more of the above aspects, the bladder has a sealed expandable chamber and a fluid port disposed in the bladder communicating from an interior volume of the sealed expandable chamber to an outside of the bladder. In any one or more of the above aspects, the integrated connector includes a base, a mating plug protruding from the base, and a connector lumen passing through the base and the mating plug, the connector lumen providing a fluid flow path from the interior volume of the sealed expandable chamber to the outside of the bladder.

[0159] An exemplary aspect relates to a method for separating a bladder from a bucket, the method comprising the steps of: inserting an end of a selective coupling tool into a hollow portion of the bucket in a space between the bladder and a sidewall of the bucket; engaging the end of the selective coupling tool with a latch plate of a receiver at least a portion of which is disposed on the sidewall of the bucket; moving the selective coupling tool in a release direction to move the latch plate from a locked state to a released state, wherein in the locked state a portion of the latch plate engages with a portion of a connector of the bladder and in the released state the portion of the latch plate disengages from the portion of the connector of the bladder; and moving the connector of the bladder in a direction away from the receiver to separate the bladder from the bucket.

[0160] In any one or more of the above aspects, engaging the end of the selective coupling tool with the latch plate of the receiver includes aligning a pin located on the end of the selective coupling tool with a corresponding hole located on the latch plate and inserting a portion of the pin into the corresponding hole located on the latch plate. In any one or more of the above aspects, aligning the pin located on the end of the selective coupling tool with the corresponding hole located on the latch plate includes positioning the selective coupling tool relative to a top surface of the bucket and aligning a scale on a shaft of the selective coupling tool with a reference point on the top surface of the bucket.

[0161] An exemplary embodiment relates to a selective coupling tool comprising a shaft extending from a proximal end to a distal end, a bifurcated extension protruding from the distal end and having a first side and a second side opposite the first side, the bifurcated extension having a cradle with a contact surface extending from the first side to the second side, and a release pin protruding from the second side.

[0162] In any one or more of the above aspects, the release pin is a frustoconical protrusion. In any one or more of the above aspects, further comprising a handle connected to the proximal end of the shaft and at least one scale disposed along a length of the shaft. In any one or more of the above aspects, the at least one scale is etched into a portion of the shaft and circumscribes at least a portion of an outer surface of the shaft.

[0163] An exemplary aspect relates to a blood separation device comprising a rotor, a bucket, a receiver, a bladder, and a connector, wherein the bucket is attached to the rotor and has a sidewall extending from an open end of the bucket to a closed end of the bucket and a hollow portion disposed between the open end of the bucket and the closed end of the bucket, the receiver is attached to the sidewall, the receiver has a body and a latch plate slidably attached to the body, the body has a receiver lumen passing from a first side of the body to a second side of the body and a receiver opening disposed around the receiver lumen, and the latch plate The bladder has an opening and an opening axis arranged parallel to the axis of the receiving portion lumen, the bladder has a sealed expandable chamber and a fluid port disposed in the bladder and communicating from an internal volume portion of the sealed expandable chamber to the outside of the bladder, the connector is attached (or adhered) to the bladder, at least a portion of the connector is disposed within the fluid port, the connector has a base, an engaging plug protruding from the base, and a connector lumen passing through the base and the engaging plug, the connector lumen providing a fluid flow path from the internal volume portion of the sealed expandable chamber to the outside of the bladder.

[0164] In any one or more of the above aspects, the base includes a planar base portion and is generally flat.

[0165] An exemplary aspect relates to a selective coupling assembly, the selective coupling assembly comprising a receiver, a bladder, and a connector, at least a portion of the receiver being disposed within a sidewall of a bladder holder, the receiver having a body and a latch plate slidably attached to the body, the body including a receiver lumen passing from a first side of the body to a second side of the body and a receiver opening disposed around the receiver lumen, the latch plate having an opening and an opening axis disposed parallel to an axis of the receiver lumen, has an expandable chamber and a fluid port disposed in the bladder communicating from an interior volume portion of the expandable chamber to an exterior of the bladder, the connector is attached (or otherwise attached) to the bladder, at least a portion of the connector is disposed within the fluid port, the connector has a base, an engaging plug protruding from the base, and a connector lumen passing through the base and the engaging plug, the connector lumen providing a fluid flow path from the interior volume portion of the expandable chamber to an exterior of the bladder.

[0166] In any one or more of the above aspects, the bladder is movable from a disengaged position that positions the bladder outside the receiving volume of the bladder holder to a retained position that positions the bladder inside the receiving volume of the bladder holder, the receiving portion being at least partially disposed within the receiving volume of the bladder holder. In any one or more of the above aspects, the connector is movable between an engaged state with the receiving portion and an unlocked state with the receiving portion, wherein in the engaged state the bladder is fixedly coupled to the bladder holder and in the unlocked state the bladder is separated from the bladder holder, and the connector is movable between the engaged state and the unlocked state from within the space inside the receiving volume of the bladder holder. In any one or more of the above aspects, the connector is movable between the engaged state and the unlocked state without the use of a tool. In any one or more of the above aspects, the connector is movable between the locked state and the unlocked state by inserting a tool from outside the receiving volume of the bladder holder into a space inside the receiving volume of the bladder holder. In any one or more of the above aspects, the bladder holder is a bucket of a separation device, the sidewall extends from an open end of the bucket to a closed end of the bucket, and the receiving volume is disposed between the open end of the bucket and the closed end of the bucket.

[0167] An exemplary aspect relates to an interconnect assembly comprising a receiver and a connector, the receiver having a body and a latch plate slidably attached to the body, the body having a receiver cavity passing from a first side of the body to a second side of the body and a receiver opening disposed around the receiver cavity, the latch plate having an opening and an opening axis disposed parallel to the axis of the receiver cavity, and the connector having a base, an engaging plug protruding from the base, and a connector cavity passing through the base and the engaging plug.

[0168] One or more of the above aspects further include a bladder having an expandable chamber and a fluid port disposed in the bladder leading from an interior volume portion of the expandable chamber to an exterior of the bladder, the connector being operably attached to the fluid port such that the connector lumen provides a fluid flow path leading from the interior volume portion of the expandable chamber to an exterior of the bladder.

[0169] Any one or more of the above aspects / embodiments substantially as disclosed herein.

[0170] Any one or more of the above aspects / embodiments substantially as disclosed herein may optionally be combined with any one or more of the other aspects / embodiments substantially as disclosed herein.

[0171] One or more means configured to carry out any one or more of the above aspects / embodiments substantially as disclosed herein.

[0172] Any one or more of the foregoing features disclosed herein.

[0173] Any one or more of the foregoing features substantially as disclosed herein.

[0174] Any one or more of the features substantially as disclosed herein may be combined with any one or more of the other features substantially as disclosed herein.

[0175] Combinations of any one of the above aspects / features / embodiments with any one or more of the other aspects / features / embodiments.

[0176] Use of any one or more of the above aspects or features disclosed herein.

[0177] The foregoing description of the embodiments has been provided for purposes of illustration and description. It is not intended to be exhaustive or to limit the present disclosure. Individual elements or features of a particular embodiment are generally not limited to that particular embodiment and, even if not specifically shown or described, may be interchangeable and used in selected embodiments, where applicable. The same may be modified in many ways. Such modifications should not be considered a departure from the present disclosure, and all such variations are intended to be included within the scope of the present disclosure.

Claims

1. A selective coupling assembly, the selective coupling assembly comprising: Bucket and With Vlada, A connector and Equipped with The bucket is a wall extending from an open end of the bucket to a closed end of the bucket, the wall at least partially defining a cavity between the open end and the closed end; a receiver attached to the wall; and The receiving portion is a body having a receptacle and a receiving lumen; a latch plate slidably attached to the body; and the receiver lumen extends between the first side of the body and the second side of the body and has a lumen axis; the latch plate has an opening and an opening axis parallel to the bore axis; The bladder a sealed expandable chamber; a fluid port communicating from the interior volume of the sealed expandable chamber to the exterior of the bladder; and the connector is attached to the bladder, at least a portion of the connector being within the fluid port; The connector comprises: A base and a plug protruding from the base; and the connector defines a connector lumen in the base and the plug, the connector lumen providing a fluid flow path from the interior volume of the sealed expandable chamber to the exterior of the bladder; Selective coupling assembly.

2. 2. The selective coupling assembly of claim 1, At least a portion of the receptacle is within the wall. Selective coupling assembly.

3. 3. The selective coupling assembly of claim 2, The plug is a recess disposed a first distance from the base of the plug; a groove formed around the plug and spaced a second distance from the base of the plug; further comprising Selective coupling assembly.

4. 4. The selective coupling assembly of claim 3, The connector further includes an O-ring at least partially disposed within the groove. Selective coupling assembly.

5. 5. The selective coupling assembly of claim 4, the connector comprises a plastic material; the connector is attached to the bladder via at least one weld; Selective coupling assembly.

6. 6. The selective coupling assembly of claim 5, the connector is movable between an engaged state with the receiving portion and an unlocked state with the receiving portion, In the locked state, the bladder is coupled to the bucket; In the unlocked state, the bladder is separated from the bucket. Selective coupling assembly.

7. 7. The selective coupling assembly of claim 6, In the locked state, the plug is at least partially disposed within the receptacle, and a portion of the latch plate is within the recess of the plug. Selective coupling assembly.

8. 8. The selective coupling assembly of claim 7, In the locked state, a fluid flow path exists between the interior volume of the sealed expandable chamber and the receiver lumen of the receiver; the fluid flow path is unobstructed by a valve between the bladder and the receptacle; Selective coupling assembly.

9. 1. A bladder assembly comprising: a flexible member; A connector and Equipped with the flexible member has a sealed expandable chamber and a fluid port communicating from an interior volume of the sealed expandable chamber to an exterior of the sealed expandable chamber; the connector is attached to the flexible member and is at least partially within the fluid port; The connector comprises: A base and a plug protruding from the base; and the connector defines a connector lumen passing through the base and the plug, the connector lumen providing a fluid flow path from the interior volume of the sealed expandable chamber to an exterior of the flexible member; Bladder assembly.

10. 10. The bladder assembly of claim 9, the connector is attached to the flexible member via a seal, the seal surrounding the fluid port and joining a portion of the flexible member to the base of the connector; Bladder assembly.

11. 1. A blood separation device, comprising: A rotor, Bucket and A receptor and With Vlada, A connector and Equipped with the bucket is attached to the rotor and has a wall extending from an open end of the bucket to a closed end of the bucket, the wall defining a cavity between the open end and the closed end; The receiver is attached to the wall; The receiving portion is a body having a receptacle and a receiving lumen; a latch plate slidably attached to the body; and the receiver lumen extends between a first side of the body and a second side of the body, the receiver lumen having a lumen axis; the latch plate has an opening and an opening axis parallel to the bore axis; The bladder a sealed expandable chamber; a fluid port extending between an interior volume of the sealed expandable chamber and an exterior of the bladder; and the connector is attached to the bladder, at least a portion of the connector being within the fluid port; The connector comprises: A base and a plug protruding from the base; a connector lumen through the base and the plug; and the connector lumen provides a fluid flow path from the interior volume of the sealed expandable chamber to the exterior of the bladder. Blood separation device.

12. A selective coupling assembly, the selective coupling assembly comprising: A receptor and With Vlada, A connector and Equipped with At least a portion of the receptacle is within a wall of the bladder holder; The receiving portion is a body having a receptacle and a first lumen; a latch plate slidably attached to the body; and the first lumen extends from a first side of the body to a second side of the body, the first lumen having a lumen axis; the latch plate has an opening and an opening axis parallel to the bore axis; The bladder an expandable chamber; a fluid port communicating from the interior volume of the expandable chamber to the exterior of the bladder; and the connector is attached to the bladder, at least a portion of the connector being within the fluid port; The connector comprises: A base and a plug protruding from the base; and the connector defines a connector lumen through the base and the plug, the connector lumen providing a fluid flow path from the interior volume of the expandable chamber to the exterior of the bladder; Selective coupling assembly.

13. 13. The selective coupling assembly of claim 12, the bladder is configured to be moved from a first position outside the bladder holder to a second position inside the bladder holder; the receptacle is at least partially within the bladder holder. Selective coupling assembly.

14. 14. The selective coupling assembly of claim 13, the connector is configured to be moved between an engaged state with the receiving portion and an unlocked state with the receiving portion; In the locked state, the bladder is coupled to the bladder holder; In the unlocked state, the bladder is separated from the bladder holder; the connector is configured to be moved between the locked and unlocked states from an interior region of the bladder holder. Selective coupling assembly.

15. 15. The selective coupling assembly of claim 14, the connector is configured to be moved between the locked and unlocked states without the use of a tool. Selective coupling assembly.

16. 15. The selective coupling assembly of claim 14, the connector is configured to be moved between the locked and unlocked states by inserting a tool into the region from outside the bladder holder. Selective coupling assembly.

17. 15. The selective coupling assembly of claim 14, the bladder holder is a bucket of a separation device; the wall extends from the open end of the bucket to the closed end of the bucket; Selective coupling assembly.

18. 1. An interconnect assembly, the interconnect assembly comprising: A receptor and A connector and Equipped with the receiver includes a body having a receptacle and a receiver bore, a latch plate slidably attached to the body, and a pin having an annular groove formed therein, the receiver bore extending between a first side of the body and a second side of the body, the receiver bore having a bore axis, and the latch plate having an opening with an opening axis parallel to the bore axis; The connector comprises: A base and a plug protruding from the base; the connector defines a connector lumen extending through the base and the plug; the interconnect assembly is variable between a locked state and an unlocked state; In the locked state, a portion of the latch plate is located within the annular groove. Interconnect assembly.

19. 20. The interconnect assembly of claim 18, the interconnect assembly further comprising a bladder having an expandable chamber and a fluid port communicating from an interior volume of the expandable chamber to an exterior of the bladder, the connector being operably attached to the fluid port such that the connector lumen provides a fluid flow path from the interior volume of the expandable chamber to an exterior of the bladder; Interconnect assembly.

20. 20. The interconnect assembly of claim 18, The plug is a recess disposed a first distance from the base of the plug; a flexible portion disposed about the plug and configured to form a seal between the plug and the receptacle; and the flexible portion is spaced a second distance from the base; Interconnect assembly.

21. 21. The interconnect assembly of claim 20, the flexible portion is a resiliently flexible ridge protruding from the plug; Interconnect assembly.

Images