Lysophosphatidic acid-containing composition

Abstract

To provide a composition having reduced stimulation of lysolecithin containing lysophosphatidic acid, and a cosmetic preparation or a topical skin preparation containing the composition.SOLUTION: A composition contains the following components (A)-(C). The inventive composition has reduced stimulation and various bioactive actions, so that is can be suitably used for a cosmetic preparation or a topical skin preparation. (A) lysolecithin containing lysophosphatidic acid, (B) a polyhydric alcohol and (C) at least one selected from hydroxides, oxides and chlorides of polyvalent metals.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a composition for cosmetics or external skin preparations containing lysophosphatidic acid, and cosmetics or external skin preparations containing the composition.

Background Art

[0002] Lysophosphatidylcholine has long been used as an emulsifier or emulsification aid in cosmetics or external skin preparations, and because of its high solubility in polyhydric alcohols such as glycerin, it is generally distributed as a polyhydric alcohol solution from the perspective of usability in the fields of cosmetics or external skin preparations. In recent years, research focusing on the functions of various lysophospholipids such as lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), lysophosphatidylserine (LPS), lysophosphatidylinositol (LPI), and lysophosphatidic acid (LPA) has been actively conducted. Under such circumstances, lysophosphatidylcholine with an increased lysophosphatidic acid content has been developed by a method using an enzyme (Patent Document 1). Regarding lysophosphatidic acid, it has been reported to have physiologically active effects useful in the fields of cosmetics or external skin preparations, such as promoting collagen production (Patent Document 1), promoting aquaporin gene expression (Patent Document 2), promoting ceramide production, and promoting tight junction formation (Non-Patent Document 1), but its use in the fields of cosmetics or external skin preparations has not progressed sufficiently.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Patent Document 3

Non-Patent Documents

[0004]

Non-Patent Document 1

[0005] The present inventors conducted various studies to promote the use of lysophosphatidic acid in the cosmetics field and found that lysolecithin containing lysophosphatidic acid has the drawback of being highly irritating. Therefore, the object of the present invention is to provide a composition that reduces the irritancy of lysolecithin containing lysophosphatidic acid, and to provide a cosmetic or topical skin preparation containing said composition. [Means for solving the problem]

[0006] The inventors of the present invention conducted extensive research to solve the above problems and found that a composition containing the following components (A) to (C) solves the aforementioned problems, thus completing the present invention. (A) Lysolecithin containing lysophosphatidic acid (B) Polyhydric alcohols (C) One or more selected from polyvalent metal hydroxides, oxides, and chlorides. [Effects of the Invention]

[0007] The compositions of the present invention have reduced irritancy and possess various physiologically active properties, and are therefore preferably used in cosmetics or topical skin preparations. [Modes for carrying out the invention]

[0008] The present invention relates to a composition for cosmetics or topical skin preparations containing the following components (A) to (C). (A) Lysolecithin containing lysophosphatidic acid (B) Polyhydric alcohols (C) One or more selected from polyvalent metal hydroxides, oxides, and chlorides.

[0009] Component (A) used in the present invention is lysolecithin containing lysophosphatidic acid and is a component that exhibits physiological activity. There are no particular restrictions on the fatty acids that form the lysolecithin of the present invention, but specifically, saturated fatty acids such as myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, and lignoceric acid; unsaturated fatty acids such as myristoleic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, erucic acid, and docosahexaenoic acid are preferred, and palmitic acid, stearic acid, oleic acid, linoleic acid, and linolenic acid are more preferred. Furthermore, the lysophosphatidic acid contained in component (A) may be in the form of salts of potassium, sodium, ammonium, triethylamine, monoethanolamine, diethanolamine, triethanolamine, lysine, arginine, etc.

[0010] There are no particular restrictions on the manufacturing method of component (A) of the present invention, and any component manufactured by known methods can be used. Specifically, it can be manufactured by enzymatically lysating lecithin containing phosphatidic acid. As the lecithin containing phosphatidic acid used in the manufacture of component (A) of the present invention, naturally occurring lecithin containing phosphatidic acid obtained from soybeans, sunflowers, etc. (for example, soybean lecithin contains about 7% by mass of phosphatidic acid) can be used as is, but it is preferable to use lecithin obtained from soybeans, rapeseed, sunflowers, safflower, peanuts, cottonseed, corn, rice, barley, egg yolk, etc., or lecithin obtained by purifying these to increase the phosphatidylcholine content, and then treating it with phospholipase D in water or a mixture of water and an organic solvent to increase the phosphatidic acid content. Component (A) of the present invention can be produced by reacting lecithin containing such phosphatidic acid with phospholipase A1 or phospholipase A2 in water or a mixture of water and an organic solvent to lyso-decompose it. The lecithin used above may be hydrogenated.

[0011] Lysolecithin obtained by the method described above may be in which the fatty acid at the sn-1 position of the glycerol skeleton has been hydrolyzed, or in which the fatty acid at the sn-2 position has been hydrolyzed. In the present invention, any type of lysolecithin may be used, or a mixture thereof may be used. Furthermore, lysolecithin obtained by the method described above may contain lysophospholipids such as lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylserine, and lysophosphatidylinositol in addition to lysophosphatidic acid, depending on the type of lecithin used as a raw material. Depending on the degree of purification, it may also contain un-lysinated phospholipids such as phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol. There are no particular restrictions on component (A) used in the present invention as long as it contains lysophosphatidic acid, and it is also preferable to use components that contain various lecithin-derived components other than lysophosphatidic acid as described above.

[0012] There are no particular restrictions on the content of lysophosphatidic acid in component (A) of the present invention, but from the viewpoint of further exhibiting the physiological activity of lysophosphatidic acid, it is preferably 15% by mass or more, more preferably 20% by mass or more. The content of lysophosphatidic acid can be measured using HPLC under the following conditions. Column: CAPCELL PAK NH2 (4.6mm I.D. × 250mm) Detector: UV (205nm) Temperature: 40℃ Mobile phase: Acetonitrile / Methanol / 10mM ammonium phosphate solution / Phosphoric acid =620 / 290 / 90 / 1 Flow rate: 1.3mL / min

[0013] The polyhydric alcohol component (B) used in this invention is added to improve usability by dissolving component (A) to form a liquid composition, thereby facilitating handling, dissolution in a medium, and dispersion of component (A) during formulation. Specifically, this includes dihydric alcohols such as ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol; and trihydric alcohols such as glycerin, trimethylolpropane, and 1,2,6-hexanetriol. Examples include sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, and mannitol; glyceryl ethers such as ethylglycerin, butylglycerin, hexylglycerin, and ethylhexylglycerin; and polyhydric alcohol polymers such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, and polyglycerin. These may be used individually or in combination of two or more. Of these, glycerin is the most preferred component from the viewpoint of solubility of component (A), and it is desirable that component (B) contains 50% by mass or more, preferably 60% by mass or more, and more preferably 70% by mass or more of glycerin.

[0014] Component (C) used in the present invention is one or more selected from polyvalent metal hydroxides, oxides and chlorides, and component (C) is blended for the purpose of reducing the irritation of component (A). The polyvalent metal may be any one selected from zinc, aluminum, calcium, barium, magnesium and iron, preferably zinc or aluminum. Specific examples thereof include zinc hydroxide, zinc oxide, zinc chloride, aluminum hydroxide, aluminum oxide, aluminum chloride, calcium hydroxide, calcium oxide, calcium chloride, barium hydroxide, barium oxide, barium chloride, magnesium hydroxide, magnesium oxide, magnesium chloride, iron hydroxide, iron oxide, iron chloride, etc., and preferably zinc hydroxide, zinc oxide, zinc chloride, aluminum hydroxide, aluminum oxide, aluminum chloride.

[0015] Regarding the contents of components (A) to (C) in the composition of the present invention, there is no particular limitation. Specifically, the content of component (A) may be 1 to 35% by mass, the content of component (B) may be 61.5 to 99.89% by mass, and the content of component (C) may be 0.01 to 3.5% by mass. Preferably, the content of component (A) is 5 to 30% by mass, the content of component (B) is 67 to 94.95% by mass, and the content of component (C) is 0.05 to 3% by mass.

[0016] The method for producing the composition of the present invention is not particularly limited, and it can be produced by stirring and mixing components (A) to (C). At this time, it is preferably carried out while heating to about 50 to 130°C.

[0017] Since the composition of the present invention has reduced irritation and various physiological activities, it can be preferably used in the applications of cosmetics or external skin preparations. There is no particular limitation on the blending amount of the composition of the present invention in cosmetics or external skin preparations, and it is usually preferably blended at about 0.01 to 60% by weight, more preferably 0.05 to 30% by weight.

[0018] The cosmetic or topical skin preparation of the present invention may optionally contain water and additives commonly used in cosmetics, such as oily bases, moisturizers / texture enhancers, surfactants, polymers / thickeners / gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant / animal / microbial extracts, UV absorbers, antibacterial / preservatives, chelating agents, pH adjusters / acids / alkalis, solvents / propellants, antipruritics, exfoliating / solubilizing agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory agents, hair growth agents / blood circulation promoters / stimulants, hormones, anti-wrinkle / anti-aging agents, irritation relievers, cooling agents, warming agents, powders, pigments / colorants / dyes / pigments, fragrances, etc., in amounts that do not impair the effects of the present invention.

[0019] As oily bases, higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachidodecanol, behenyl alcohol, jojoba alcohol, chymyl alcohol, cerachidodecanol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimergol, etc.; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, Undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and other higher fatty acids, as well as metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, and sodium salts thereof, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin Hydrocarbons such as α-olefin oligomers, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, and olive oil. Vegetable oils such as castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, peach kernel oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.; animal waxes such as whale wax, lanolin, orange roughy oil, etc.Lanolins such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, and (cetyl lanolyl) acetate; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin; Phospholipids such as gophospholipids, phosphatidic acid, cyclic lysophosphatidic acid or its salts, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroyl sarcosinate isopropyl, etc. Acyl sarcosinate alkyl Sterol esters such as cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palimitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolate, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, Monoalcoholic carboxylic acid esters such as ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolinate, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc.; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, diisostearyl malate;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicaprylic trioctanoate Neopentyl glycol dioctanoate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate / sebacate), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearate / stearate / rosinate), diglyceryl diisostearate, polyglyceryl tetraisostearate Polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucic acid / isostearate / ricinoleic acid), diglyceryl oligoester (hexyldecanoic acid / sebacic acid), glycol distearate (ethylene glycol distearate), polyhydric alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dieopentanoate and 2,4-diethyl-1,5-pentanediol dieopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dimer dilinoleate, dima Dimer acids or dimer ol derivatives such as diisostearyl dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil of dimer dilinoleate, and hydroxyalkyl dimer dilinoleyl ether;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethylaminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone Silicones such as corn rubber, amino-modified silicones like aminopropyl dimethicone and amodimethicone, cationic-modified silicones, polyether-modified silicones like dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfuric acid-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cationic-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amide-alkyl-modified silicones, amino glycol-modified silicones, aminophenyl-modified silicones, and polysiloxane-oxyalkylene copolymers are preferred; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are also preferred.

[0020] As moisturizers and texture enhancers, polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol / propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; and sugars such as sorbitol, xylitol, erythritol, mannitol, and maltitol. Glucolic compounds; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrins, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycan Sugars and their derivatives such as cogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, kerato sulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts;Amino acids and their salts such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, collagen, fish collagen, atelocollagen, gelatin, elastin, collagen-degraded peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptides, keratin-degraded peptides, hydrolyzed keratin, conchiolin-degraded peptides, hydrolyzed conchiolin, silk protein-degraded peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degraded peptides, small Protein peptides and their derivatives such as wheat proteolytic peptides, hydrolyzed wheat protein, casein proteolytic peptides, and acylated peptides; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides, and palmitoyl tetrapeptides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycosides, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, air Preferred ingredients include animal and plant extracts such as rustin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose extract, yarrow extract, eucalyptus extract, and sweet clover extract; and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, sphingoglycolipids, and ceramide and glycoceramide-containing extracts.

[0021] Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymeric surfactants. There are no particular restrictions on the HLB of surfactants; those with a low HLB of around 1 to a high HLB of around 20 can be used, and combinations of low and high HLB surfactants are also preferred. Examples of preferred surfactants include, among anionic surfactants, fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methylalanine, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamate methylalanine; and sodium cocoyl glutamate, triethanolamine cocoyl glutamate, and sodium lauroyl glutamate. Acyl amino acid salts such as sodium myristoyl glutamate, sodium stearoyl glutamate, palmitoyl aspartate ditriethanolamine, cocoyl alanine triethanolamine, sodium dilauroyl glutamate lysine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinate esters such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty acid amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as hydrogenated coconut oil fatty acid glycerin sulfate sodium; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and sodium dioctyl sulfosuccinate;Alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate, triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooleth phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or their salts; carboxylic acid-modified silicones, phosphate-modified silicones, sulfuric acid-modified silicones, etc. Lycorn-based anionic surfactants, etc.; nonionic surfactants include various polyoxyethylene alkyl ethers with different polyoxyethylene addition numbers, such as laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), beheneth (polyoxyethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), octyldodeceth (polyoxyethylene octyldodecyl ether), etc.; polyoxyethylene alkylphenyl ethers Castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyloglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl. ) Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocottonseed oil fatty acid glycerin, monoerucate glycerin, sesquioleate glycerin, α,α'-oleate pyroglutamate glycerin, monostearate glycerin malic acid and other glycerin fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, 8 stearate , same 10, polyglyceryl-6 distearate, same 10, polyglyceryl-2 tristearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 isostearate, same 3, same 4, same 5, same 6, same 8, same 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), same 3, same 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, same 3, Polyglycerin fatty acid esters such as Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, Polyglyceryl-10 decaoleate; Ethylene glycol monofatty acid esters such as Ethylene glycol monostearate; Propylene glycol monofatty acid esters such as Propylene glycol monostearate; Pentaerythritol partial fatty acid ester; Sorbitol partial fatty acid ester; Maltitol partial fatty acid ester; Maltitol ether;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan penta-2-ethylhexyl diglycerol sorbitan, sorbitan tetra-2-ethylhexyl diglycerol sorbitan; sugar derivative partial esters such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides Glycolipids such as mannosylerythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleate such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate. Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate, and other polyoxyethylene sorbitan fatty acid esters; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate, and other polyoxyethylene sorbitol fatty acid esters; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chymyl alcohol, cerakyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids;Polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA). Examples include: alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, sugar-modified silicones, and other silicone-based nonionic surfactants; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, and cetrimonium chloride. Alkyltrimethylammonium chlorides such as lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amide amines and their salts such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl etheramines and their salts or quaternary salts such as stearoxypropyldimethylamine; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidium salts; alkyl etheramine mononium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmolyphonium salts; polyamine fatty acid derivatives;Silicone-based cationic surfactants such as aminopropyl dimethicone and amodimethicone (amino-modified silicones), cationic-modified silicones, cationic-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, etc.; amphoteric surfactants such as N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaines such as alkyldimethyl taurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Phosphingolipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants, etc.; polymeric surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers; and various silicone-based surfactants are preferred.

[0022] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed gum, carrageenan, galactan, gum arabic, tara gum, tamarind, fercerelan, karaya gum, okra gum, tragacanth gum, pectin, pectic acid and its salts, alginic acid and its salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosa Agar, cassia seed extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, carboxylated cellulose nanofiber, carboxymethylated cellulose nanofiber, phosphate-esterified cellulose nanofiber, sulfonated cellulose nanofiber, sodium cellulose sulfate, dialkyldimethylammonium sulfur Cellulose and its derivatives such as cellulose acid, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, and methyl starch; starch derivatives such as hydroxypropyltrimonium chloride starch and aluminum corn starch octenyl succinate; alginate derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpyridone-vinyl alcohol copolymer, and polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, and polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer and (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, and (alkyl acrylate / diacetone acrylamide) copolymer AMP;Polyvinyl acetate partially saponified, maleic acid copolymer; vinylpyrrolidone dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as ethyl polyacrylate, carboxyvinyl polymer, salts such as polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-39, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylamide copolymer, polyquaternium-47, etc. Copolymers of lylic acid, methyl acrylate, methacrylamidopropyltrimethylammonium chloride, choline methacrylate ester polymer; cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimonium chloride, and other cationized polysaccharides; polyethyleneimine; cationic polymers; polymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and butyl methacrylate copolymers, etc.; polymer emulsions such as acrylic resin emulsions, ethyl polyacrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate;Preferred materials include anhydrous silicic acid, fuzzy silica (ultrafine particle anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl metal phosphates, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

[0023] Preferred antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Antioxidants include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as monostearate, monopalmitate, dipalmitate, and tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; and ascorbic acid Preferred materials include ascorbic acid derivatives such as sulfuric acid esters and tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinyl acetate, retinyl palmitate, and hydrogenated retinol; vitamin E compounds such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanidin, catechin, ellagic acid, quercetin, and apple polyphenols; and coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, and platinum nanocolloids.

[0024] Whitening agents include hydroquinone glycosides and their esters such as arbutin and α-arbutin; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbic acid phosphate salt and magnesium ascorbic acid phosphate salt; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; and ascorbic acid esters such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid. Preferred materials include: ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; tranexamic acid derivatives such as tranexamic acid, tranexamic acid cetyl, and tranexamic acid amide; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, willow extract, and saxifrage extract.

[0025] Vitamins and their derivatives include vitamin A compounds such as retinol, retinyl acetate, and retinyl palmitate; vitamin B compounds such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acid compounds, nicotinic acid compounds such as nicotinamide and benzyl nicotinate, and choline compounds; vitamin C compounds such as ascorbic acid and its sodium salts; vitamin D; vitamin E compounds such as α, β, γ, and δ-tocopherols; other vitamins such as pantothenic acid and biotin; and ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred materials include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as tetraisopalmitic ascorbate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, alkyl ascorbic acid ethers such as ethyl ascorbate, ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters, ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate esters, tocotrienols, and various other vitamin derivatives.

[0026] Plant, animal, and microbial extracts include iris extract, angelica extract, Thujopsis dolabrata extract, asparagus extract, avocado extract, Hydrangea macrophylla extract, almond extract, marshmallow extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, fig extract, fennel extract, turmeric extract, oolong tea extract, bearberry extract, rosehip extract, Echinacea leaf extract, Enmeisou extract, scutellaria extract, phellodendron bark extract, Coptis japonica extract, barley extract, ginseng extract, St. John's wort extract, and Lamium album. Grass extract, Ononis extract, Nasturtium extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Arctium extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Artemisia capillaris extract, Oat extract, Chloranthus extract, Licorice extract, Oil-soluble licorice extract, Kiwi extract, Kelp extract, Wood ear mushroom extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora flavescens extract, Gardenia extract, Sasa veitchii extract, Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentian extract, Geranium thunbergii extract, black tea extract, yeast extract, Magnolia bark extract, coffee extract, burdock extract, rice extract, rice fermentation extract, rice bran fermentation extract, rice germ oil, comfrey extract, collagen, lingonberry extract, Asarum sieboldii extract, Bupleurum chinense extract, umbilical cord extract, saffron extract, sage extract, soapwort extract, bamboo extract, hawthorn extract, sunflower extract Kiss, Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, birch extract, white fungus extract, horsetail extract, stevia extract, stevia ferment, iris extract, ivy extract, hawthorn extract, elderberry extract, yarrow extract, peppermint extract, sage extract, mallow extract, chuanxiong extract, swertia japonica extract, mulberry bark extract, rhubarb extract,Soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cogongrass extract, citrus peel extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, Ophiopogon extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, Isodon japonicus extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, Poria cocos extract, butcher's broom extract, grape extract, grape seed extract Preferred extracts include those of kiss, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, cypress extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, lemon balm extract, seaweed extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi mushroom extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and Sanguisorba officinalis extract.

[0027] UV absorbers include benzoic acid-based UV absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxypara-aminobenzoate ethyl ester, N,N-diethoxypara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate butyl ester, and N,N-dimethylpara-aminobenzoate ethyl ester; anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based UV absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; and octyl cinnamate. Cinnamic acid-based UV absorbers such as ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxy cinnamate (cinoxate), cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, ferulic acid and its derivatives;Benzophenone-based UV absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydro Xy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzarazine; dianisioylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butyl methoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanic acid; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; Preferred materials include benzotriazole (nyl), 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, and other hydantoin derivatives, phenylbenzimidazol sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

[0028] As antibacterial and preservative agents, parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalconium chloride Preferred substances include benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenols, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol and other phenols; phenylethyl alcohol, photosensitizers, antimicrobial zeolites, and silver ions. However, when used as an antimicrobial agent or preservative for preservation purposes, from the viewpoint of safety for cosmetics or topical skin preparations, it is more preferable to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkylglyceryl ethers such as 2-ethylhexylglyceryl ether.

[0029] Preferred chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and their sodium salts; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0030] Preferred pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0031] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and di Preferred propellants include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, and carbon dioxide.

[0032] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, and glycolic acid. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringent agents include citric acid, tartaric acid, lactic acid, potassium aluminum sulfate, tannic acid, and caffeine. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0033] Preferred anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, gingerol, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate; γ-oryzanol, nicotinic acid and derivatives such as nicotinamide, benzyl nicotinate, inositol hexanicotinate, and nicotinic alcohol; allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmamanol and its glycosides; and minoxidil. Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0034] Anti-wrinkle and anti-aging agents include: ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as monostearate, monopalmitate, dipalmitate, and tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucosides and their fatty acid esters such as ascorbic acid-2-glucoside; and ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate. Preferred materials include: Vitamin A compounds such as retinol, retinyl acetate, retinyl palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanidin, pantothenic acid, panthenol, soy saponin, revelastol, isoflavone, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolysate, adenosine 5'-monophosphate, phosphatidylinositol, sodium trifluoride isopropyl oxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetate, tranexamic acid and its derivatives.

[0035] Preferred irritation-reducing agents include mannosylerythritol lipid, diethylene glycol dimer dilinoleate oligomer ester, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, and polypropylene glycol. Preferred cooling agents include menthol, camphor, menthyl lactate, monomentyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, and derivatives thereof. Preferred warming agents include vanillin and its derivatives, vanillyl nonanoate, gingerol, capsicum tincture, capsicum extract, benzyl nicotinate, methyl nicotinate, phenyl nicotinate, tocopherol nicotinate and other nicotinic acid derivatives, capsaicin, watercress extract, sansho pepper extract, ginger extract, and canthari extract.

[0036] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium dioxide, fine and ultrafine titanium dioxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fuzzy silica (ultrafine anhydrous silicic acid), and titanium mica. Preferred materials include inorganic powders of various sizes and shapes such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorphlogopite, fine particle composite powders, gold, aluminum, and inorganic powders that have been hydrophobized or hydrophilized by treating them with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents; organic powders of various sizes and shapes such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, Teflon® powder, and other organic powders and surface-treated powders, as well as organic-inorganic composite powders.Preferred inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as 1Na, 2Na, and 3Na phosphates, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0037] As pigments, colorants, dyes, and dyes, these include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402 Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223 , Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 40 No. 4, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange 20 Statutory dyes such as No. 5, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5, etc.; Acid Other acid dyes such as Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and lower titanium oxide;Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin Natural pigments and dyes such as tin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidative dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-,m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and their salts; auto-oxidative dyes such as indoline; and dihydroxyacetone are preferred.

[0038] The fragrance ingredients include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-esuper, isobutylquinoline, iris oil, ylone, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragol, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carbone, camphor, canone, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedyl acetate, terepinel acetate, and pt-butylcyclohexyl acetate. Lu, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanol, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, α-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Peruvian Balsam, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzoate Preferred examples include synthetic and natural fragrances such as benzoate, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, liral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances.

[0039] In addition to tap water and purified water, preferred types of water include hard water, soft water, natural water, deep-sea water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and clustered water.

[0040] In addition to these, it is possible to include known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, formulation ratios, and amounts, such as ingredients listed in the Cosmetic Raw Material Standards, Cosmetic Ingredient Formulation Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Material Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Compendium, etc., as well as ingredients listed in Japanese and foreign patent gazettes and patent publications (including published and republished gazettes) belonging to the International Patent Classification IPC A61K7 and A61K8 classifications.

[0041] Examples of cosmetic compositions of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, fragrance cosmetics, and body cosmetics. Cosmetics of the present invention can be manufactured according to conventional methods.

[0042] To further describe the types of cosmetics of the present invention, preferred hair cosmetics include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, anti-dandruff shampoos, hair color shampoos, and rinse-integrated shampoos; hair care products such as rinses, conditioners, treatments, hair packs, leave-on treatments, hair mists, and hair oils; hair styling products such as hair foams, hair mousses, hair sprays, hair waxes, hair gels, hair creams, water greases, setting lotions, pomades, and hair sticks; hair dyes such as color lotions, hair color treatments, hair manicures, and oxidative hair dyes; and hair tonics, hair liquids, hair blowers, split end coats, permanent wave agents, straight perm agents, hair bleaches, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, and hair growth agents.

[0043] Skin cosmetics include toners such as softening toners, astringent toners, cleansing toners, multi-layer toners, and liposome toners; lotions such as emollient lotions, moisturizing lotions, milky lotions, nourishing lotions, nourishing milks, skin moisturizers, moisturizing emulsions, massage lotions, exfoliating smoothers, elbow lotions, hand lotions, and body lotions; emollient creams, nourishing creams, nourishing creams, vanishing creams, moisturizing creams, night creams, massage creams, cleansing creams, makeup creams, base creams, pre-makeup creams, sunscreen creams, suntan creams, hair removal creams, deodorant creams, shaving creams, and exfoliating creams. Preferred products include skincare cosmetics such as creams including softening creams, moisturizing gels, whitening gels, all-in-one gels, moisturizing essences, whitening essences, moisturizing serums, whitening serums, and other beauty serums; sunscreen cosmetics such as sun protectors, sun protectors, UV care milks, and sunscreens; packs and masks such as peel-off packs, powder packs, washing packs, oil packs, and cleansing masks; cleansing cosmetics such as cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, and cleansing oils; and facial cleansers such as paste facial cleansing foams, gel facial cleansing foams, foaming facial cleansing foams, facial cleansing powders, cosmetic soaps, clear soaps, medicated soaps, liquid soaps, and shaving soaps.

[0044] Preferred makeup products include lipstick, lip gloss, foundation, blush, face powder, concealer, eyeliner, mascara, eyeshadow, eyebrow pencil, eyebrow products, nail polish, nail polish remover, and nail treatment.

[0045] Preferred fragranced cosmetics include perfumes, fragrances, parfums, eau de parfums, eau de toilettes, eau de colognes, solid perfumes, fragrance powders, fragranced soaps, body lotions, and bath oils.

[0046] Preferred body cosmetics include body washes such as body shampoos, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks, deodorizing cosmetics, bleaching agents, hair removal agents, bath additives, and insect repellents such as insect repellent sprays.

[0047] The present invention can be used as a topical skin preparation in the form of an ointment, lotion, cream or gel, patch, liniment, or liquid application. It can also be used as an oral cosmetic such as toothpaste or mouthwash.

[0048] Preferred dosage forms for the cosmetic or topical skin preparation of the present invention include emulsified cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type, as well as oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.

[0049] The present invention will be further described in detail by the following examples, but the present invention is not limited thereto.

[0050] Synthesis Example 1: Synthesis of Lysophosphatidic Acid-Containing Lysolecithin In a 200 mL reaction vessel equipped with a stirrer, thermometer, gas inlet tube, and condenser, 21 g of soybean lecithin (SLP-PC70, manufactured by Tsuji Oil Co., Ltd.), 23.8 g of n-heptane, and 31.5 g of ethyl acetate were charged and dissolved by stirring at 40°C. Next, 0.7 g of phospholipase D (manufactured by Meito Sangyo Co., Ltd.), 36.4 g of 1.0 M sodium acetate buffer (pH 6.5), and 0.21 g of calcium chloride were charged and the reaction was carried out by stirring at 40°C for 20 hours. After the reaction, 16.6 g of ethanol was added and stirred for 0.5 hours, then 22.5 g of 10 wt% sodium chloride aqueous solution was added and stirred, and the mixture was allowed to stand and separated. 280 g of acetone was added to the resulting upper layer, and the precipitated solid was filtered off and dried to obtain lecithin containing sodium phosphatidic acid as a yellow viscous solid. In a 200 mL reaction vessel equipped with a stirrer, thermometer, gas inlet tube, and condenser, 14.0 g of the yellow viscous solid obtained above, 34.0 g of n-heptane, and 22.5 g of ethyl acetate were charged and dissolved by stirring at 40°C. Next, 0.21 g of phospholipase A2 (Nagase 10P / R, manufactured by Nagase Chemtec), 7.0 g of 1.0 M sodium acetate buffer (pH 6.5), and 0.14 g of calcium chloride were charged and the reaction was carried out by stirring at 40°C for 20 hours. After the reaction, 36.4 g of ethanol was added and stirred for 0.5 hours, then 25.9 g of 10 wt% sodium chloride aqueous solution was added and stirred, and the mixture was allowed to stand and separated. 415 g of acetone was added to the resulting lower layer, and the precipitated solid was filtered off and dried to obtain lysolecithin containing sodium lysophosphatidic acid as a yellow solid (yield 45%). The lysophosphatidic acid content was 25.8% by mass. The fatty acid composition was 30% palmitic acid, 7% stearic acid, 13% oleic acid, 42% linoleic acid, 3% linolenic acid, and 5% other.

[0051] Synthesis Example 2: Synthesis of Lysophosphatidic Acid-Containing Lysolecithin The synthesis was carried out in the same manner as in Synthesis Example 1, except that phospholipase A2 was replaced with phospholipase A1 (manufactured by Mitsubishi Food Chemical Co., Ltd.), and lysolecithin containing sodium lysophosphatidic acid was obtained as a yellow solid (yield 48%). The lysophosphatidic acid content was 26.3% by mass. The fatty acid composition was palmitic acid 11%, stearic acid 3%, oleic acid 20%, linoleic acid 61%, linolenic acid 4%, and others 1%.

[0052] Example 1: Preparation of the composition of the present invention The composition of the present invention was obtained by stirring and mixing 2.5 g of lysophosphatidic acid-containing lysolecithin obtained in Synthesis Example 1, 7.375 g of glycerin, and 0.125 g of aluminum hydroxide at 70°C for 3 hours.

[0053] Example 2 Preparation of the composition of the present invention The composition of the present invention was obtained by stirring and mixing 2.5 g of lysophosphatidic acid-containing lysolecithin obtained in Synthesis Example 1, 7.375 g of glycerin, and 0.125 g of zinc oxide at 70°C for 3 hours.

[0054] Example 3 Preparation of the composition of the present invention The composition of the present invention was obtained by stirring and mixing 2.5 g of lysophosphatidic acid-containing lysolecithin obtained in Synthesis Example 2, 7.375 g of glycerin, and 0.125 g of aluminum hydroxide at 70°C for 3 hours.

[0055] Example 4 Preparation of the composition of the present invention The composition of the present invention was obtained by stirring and mixing 2.5 g of lysolecithin containing lyrisophosphatidic acid obtained in Synthesis Example 2, 7.375 g of glycerin, and 0.125 g of zinc oxide at 70°C for 3 hours.

[0056] Comparative Example 1: Preparation of comparative composition A comparative composition was obtained by stirring 2.5 g of lysolecithin containing lysophosphatidic acid, obtained in Synthesis Example 1, and 7.5 g of glycerin at 70°C for 3 hours.

[0057] Comparative Example 2: Preparation of comparative compositions 2.5 g of lysophosphatidic acid-containing lysolecithin obtained in Synthesis Example 2 and 7.5 g of glycerin were stirred and mixed at 70°C for 3 hours to obtain a comparative composition.

[0058] <Stimuli Assessment> For each test substance listed in Table 1, a 1% or 10% aqueous solution was prepared and used as the test solution. The irritation of the obtained test solutions was evaluated using the SIRC-STE method, which is included in the OECD test guidelines (TG491), as an alternative to the Draize test using rabbits, which was a commonly used method for evaluating irritation to the eyes and mucous membranes. Test method Rabbit corneal epithelial cells (SIRCs) were placed in a 96-well plate in a 6.0 × 10⁶ format. 3 Cells were seeded in 200 μL of solution at a concentration of cells / well and cultured for 4 days. After culturing, the culture medium was removed, and 200 μL each of 5% physiological saline solution of the test solution, 0.05% physiological saline solution of the test solution, and physiological saline as a control were added. After exposure for 5 minutes, the test samples were removed and washed three times with PBS(-). Then, 200 μL of 0.5 mg / mL MTT solution was added and reacted for 2 hours. After removing the MTT solution, 200 μL of isopropanol containing 0.04 mol / L hydrochloric acid was added to extract formazan for 1 hour. After extraction, the absorbance at 570 nm (OD570) of the extract was measured using a microplate reader, and the cell viability was calculated using the following formula with the average OD570 of the three wells. The experiment was performed three times, and the results are shown in Table 1 as the average cell viability obtained in each experiment.

[0059]

number

[0060] [Table 1]

[0061] The results in Table 1 show that the compositions of the present invention containing components (A) to (C) had higher cell viability and lower irritancy compared to compositions that did not contain component (C).

[0062] <Evaluation of physiological activity> Normal human epidermal keratinocytes were placed in a 24-well plate in a 1.0 × 10⁶ arrangement. 5 Cells were seeded at a concentration of cells / well and cultured in HuMedia-KB2 medium (Kurabo Industries Ltd.) for 16 hours. Then, each test substance listed in Table 1 was added to the medium at a concentration of 25 ppm, and cultured for a further 4 hours. Subsequently, the gene expression levels of various proteins (standardized by GAPDH) were measured by real-time PCR. As a control, the gene expression levels of various proteins were similarly measured without the addition of the test substances. The results are shown in Table 2 as relative values, using the average of 3 wells and setting the control expression level to 100.

[0063] [Table 2]

[0064] Table 2 shows that the composition of the present invention significantly increased the gene expression levels of HAS3, CLDN1, CLDN4, OCLN, ZO-2, INV, and TGM compared to the control. CLDN1, CLDN4, OCLN, ZO-2, and TGM were expressed more in the composition than in the control which did not contain component (C). HAS3 is a hyaluronic acid synthase abundant in the epidermis, and increased HAS3 gene expression leads to increased hyaluronic acid production in the epidermis. CLDN1, CLDN4, OCLN, and ZO-2 are proteins that form tight junctions, which govern cell adhesion, and increased gene expression levels of these proteins lead to increased tight junction formation. INV is a protein that forms the cornified envelope, an insoluble membrane surrounding keratinocytes, and TGM is an enzyme that acts during the formation of the cornified envelope; increased gene expression levels of these proteins lead to increased maturation of the cornified envelope.

[0065] The following cosmetic composition was prepared using the composition of the present invention. The resulting cosmetic composition has excellent moisturizing and penetrating properties and prevents fine lines and rough skin.

[0066] Example 5: Moisturizing lotion Component Amount (wt%) -------------------------------------- Part A Composition of Example 1 0.5 BG 5.0 1,2-Pentanediol 3.0 Purified water 20.0 Part B Neosolue-Aqulio (Nippon Seika) 1.0 Glucosylceramide 0.5 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) Parts A and B were mixed uniformly at approximately 40°C. A and B were then mixed to form a homogeneous liquid.

[0067] Example 6: Moisturizing lotion Component Amount (wt%) -------------------------------------- Composition of Example 2 3.0 Phenoxyethanol 0.4 Sodium citrate (appropriate amount) Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) All ingredients were mixed at approximately 40°C, and sodium citrate was added to achieve a pH of 6.5-7.0 to create a homogeneous solution.

[0068] Example 7: Moisturizing lotion Component Amount (wt%) -------------------------------------- Composition of Example 4 1.0 Phenoxyethanol 0.4 Hydroxyethylcellulose 0.2 Carbomer 0.1 Arginine 0.1 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) All components were uniformly mixed at approximately 40°C to obtain a homogeneous liquid.

[0069] Example 8: Moisturizing lotion Component Amount (wt%) ------------------------------------- Part A Composition of Example 3 0.5 Diglycerin 1.0 Glycerin 8.0 BG 3.0 Plandool-LG2 (Nippon Seika) 0.1 Plandool-ISS (Nippon Fine Chemical) 0.05 Cholesterol 0.1 Part B Purified water 30.0 C part Maltitol solution 1.0 Betaine 0.5 α-Glucan oligosaccharide 0.1 Pullulan 0.5 Tuberose polysaccharide 0.01 Hydroxypropyl methylcellulose stearoxy ether 0.05 (Acrylates / C10-30 Alkyl Acrylate) Crosspolymer 0.05 Arginine 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A and B were heated to 70°C each. Part A was added to Part B while stirring with a homomixer (7000 rpm) to prepare a nano-dispersion. The dispersion was then further dispersed using a high-pressure emulsifier (Mizuho Industries Microfluidizer). After cooling, pre-mixed Part C was added to create a homogeneous liquid.

[0070] Example 9: Moisturizing lotion Component Amount (wt%) ------------------------------------- Part A Composition of Example 3 3.5 Diglycerin 1.0 Glycerin 8.0 Plandool-LG2 (Nippon Seika) 0.1 Plandool-ISS (Nippon Fine Chemical) 0.05 Phytosterol 0.1 Tocopherol 0.05 Part B Purified water 30.0 C part Betaine 0.5 Nicotinamide 5.0 Tranexamic acid (Nippon Seika) 1.0 Phenoxyethanol 0.2 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A and B were heated to 70°C each. Part A was added to Part B while stirring with a homomixer (7000 rpm) to prepare a nano-dispersion. After cooling, pre-mixed Part C was added to create a homogeneous solution.

[0071] Example 10: Moisturizing lotion Component Amount (wt%) -------------------------------------- Part A Composition of Example 1 5.0 BG 2.0 1,2-Pentanediol 3.0 Purified water 20.0 Part B Neosolue-Aqulio (Nippon Seika) 1.0 Tranexamic acid (Nippon Seika) 2.0 Phenoxyethanol 0.4 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) Parts A and B were mixed uniformly at approximately 40°C. A and B were then mixed to form a homogeneous liquid.

[0072] Example 11: Moisturizing lotion Component Amount (wt%) -------------------------------------- Part A Phytopresome-MEL (Nippon Seika) 0.8 PrimeLipid-PI (Nippon Fine Chemical) 1.0 BG 5.0 Glycerin 10.0 1,2-Hexanediol 3.0 Part B Purified water, in an amount that totals 100. C part Composition of Example 1 7.0 Sodium cyclic lysophosphatidic acid 0.001 Neosolue-AquaS (Nippon Fine Chemical) 1.0 PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin 0.5 Polyquaternium-51 0.5 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water 20.0 -------------------------------------- (Preparation method) Parts A and B were heated to 70°C each. Part A was added to part B while stirring with a homomixer (7000 rpm) to prepare the nanovesicle liquid. After further cooling, part C, which had been mixed beforehand, was added to create a homogeneous liquid.

[0073] Example 12: Whitening lotion Component Amount (wt%) -------------------------------------- Composition of Example 1 10.0 Glycerin 8.0 1,3-Propanediol 7.0 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 Arbutin (Nippon Seika) 1.0 Ethanol 3.0 DPG 2.0 Methyl Gluceth-10 2.0 Dipotassium glycyrrhizate 0.05 Tremoist-TP (Nippon Fine Chemical) 0.01 Xanthan gum 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Citric acid 0.1 Sodium citrate 0.2 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to obtain a homogeneous liquid.

[0074] Example 13: Whitening lotion Component Amount (wt%) -------------------------------------- Part A Composition of Example 4 5.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Tranexamic acid (Nippon Seika) 2.0 Nicotinamide 5.0 Phytic acid 0.3 Purified water 20.0 Part B BG 5.0 Tripropylene glycol 2.0 Sodium hyaluronate 0.01 DPG 2.0 Carbomer 0.01 Phenoxyethanol 0.4 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) Parts A and B were each measured into containers and stirred with a paddle at room temperature to obtain a homogeneous liquid. Part A was then mixed with part B to obtain a homogeneous liquid.

[0075] Example 14: Gel lotion Component Amount (wt%) ------------------------------------- Part A Composition of Example 1 3.0 Glycerin 10.0 Sorbitol solution (70%) 5.0 PEG-10 Dimethicone 0.4 Glucose 1.0 BG 3.0 Purified water 20.0 Part B Pullulan 0.2 Ethylhexylglycerin 0.2 Polymethacryloyl lysine 0.05 Crystalline cellulose powder 0.1 Locust bean gum 0.03 Hydroxyethylcellulose 0.05 Xanthan gum 0.05 Sodium hyaluronate 0.01 Tranexamic acid (Nippon Seika) 2.0 Carbomer 0.06 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) Parts A and B were each measured into containers and stirred with a paddle at room temperature to obtain a homogeneous liquid. Part A was then mixed with part B to obtain a homogeneous liquid.

[0076] Example 15: Transparent Gel Component Amount (wt%) ------------------------------------- Part A Composition of Example 2 2.0 PrimeLipid-PI (Nippon Fine Chemical) 0.2 Glycerin 5.0 PPG-6 Decyltetradeceth-30 0.2 PEG-30 Phytosterol 0.3 Purified water 30.0 Part B PEG-4M 0.2 Methylgluceth-10 1.0 Pyridoxine hydrochloride 0.05 Ethylhexylglycerin 0.2 Phenoxyethanol 0.4 Tranexamic acid (Nippon Seika) 2.0 Tremoist-TP (Nippon Fine Chemical) 0.01 Hydrolyzed collagen 0.01 Purified water, in an amount that totals 100. (Dimethyltaurate Ammonium Acrylate / Vinylpyrrolidone) Copolymer 0.05 (Acrylates / C10-30 Alkyl Acrylate) Crosspolymer 0.15 Arginine 0.25 -------------------------------------- (Preparation method) Parts A and B were each measured into containers and stirred with a paddle at room temperature to obtain a homogeneous liquid. Part A was then mixed with part B to obtain a homogeneous liquid.

[0077] Example 16: Scalp Lotion Component Amount (wt%) -------------------------------------- Composition of Example 1 3.0 Maltitol solution 0.5 PEG-60 Hydrogenated Castor Oil 0.3 Ethanol 10.0 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Betaine 0.2 Hydroxypropyl chitosan solution 0.05 Carrot extract 0.1 Pyridoxine hydrochloride 0.05 Panthenol 0.1 Dipotassium glycyrrhizinate 0.1 Phenoxyethanol 0.3 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to obtain a homogeneous liquid.

[0078] Example 17: Scalp Lotion Component Amount (wt%) ------------------------------------- Composition of Example 1 2.0 1,2-Hexanediol 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Tocopherol acetate 0.05 Menthol 0.1 Betaine 0.2 Swertia japonica extract 0.1 Stephania tetrandra root extract 0.003 Hinokitiol 0.1 PCA-Na 0.1 Carbomer 0.01 K hydroxide 0.01 Pentasodium pentetate 0.05 Phenoxyethanol 0.4 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to obtain a homogeneous liquid.

[0079] Example 18: Hair growth agent Component Amount (wt%) ------------------------------------- Glycerin 2.0 Composition of Example 2 1.0 PEG-60 Hydrogenated Castor Oil 0.3 Betaine 0.5 Ethanol 20.0 Menthol 0.1 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Orange oil 0.05 Panthenyl ethyl ether 0.2 Carrot extract 1.0 Sophora angustifolia extract 2.0 Chlorella extract 1.0 Trehalose 0.5 Nicotinamide 1.0 Piroctone olamine 0.1 Dipotassium glycyrrhizinate 0.1 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to obtain a homogeneous liquid.

[0080] Example 19: Hair growth agent Component Amount (wt%) ------------------------------------- Composition of Example 4 4.0 Phytopresome-MEL (Nippon Seika) 1.0 Neosolue-Aqulio (Nippon Seika) 0.5 DPG 2.0 Lactic acid 0.1 Tremoist-TP (Nippon Fine Chemical) 0.01 Ethanol 10.0 Menthol 0.1 Menthyl glyceryl ether 0.15 Panthenyl ethyl ether 0.2 Camphor 0.1 Cordyceps sinensis extract 1.0 Swertia japonica extract 1.0 Loquat leaf extract 1.0 Hydrolyzed hyaluronic acid 0.02 Sodium cyclic lysophosphatidic acid 0.001 Chili pepper extract 0.01 Betaine 0.3 Trehalose 0.2 Cymene-5-ol 0.1 Tocopherol acetate 0.05 β-Glycyrrhetinic acid 0.05 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) All ingredients were weighed into a container and stirred with a paddle at room temperature to obtain a homogeneous liquid.

[0081] Example 20: Whitening lotion Component Amount (wt%) -------------------------------------- Part A Plandool-DP (Nippon Fine Chemical) 1.0 Cetyl ethylhexanoate (Nippon Seika) 10.0 Cetanol 1.2 Dimethicone 100 cs 3.0 Myristyl alcohol 2.0 Oleyl alcohol 1.0 Part B Stearoxyhydroxypropylmethylcellulose 0.1 Xanthan gum 0.1 Sodium citrate (appropriate amount) Purified water 20.0 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 Glycerin 8.0 D part 3-O-ethyl ascorbic acid (Nippon Seika) 0.5 Tranexamic acid (Nippon Seika) 2.0 Nicotinamide 5.0 Composition of Example 2 1.0 Purified water 5.0 Part E Phenoxyethanol 0.2 Methylparaben 0.15 Phytic acid 0.5 Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) Parts A and E were heated to approximately 70°C and dissolved uniformly. Part B was stirred to make a viscous liquid. Part C was heated to approximately 70°C and dispersed uniformly. Part A was added to Part C while stirring in a homodisperser, and then Part E was added while stirring. Parts D and B were added at approximately 50°C, stirred to mix uniformly, and the pH was adjusted to 6.5-7.0 with sodium citrate.

[0082] Example 21 Emulsion Component Amount (wt%) ------------------------------------- Part A Glycerin 3.0 Diglycerin 1.0 BG 5.0 Phytocompo-C (Nippon Fine Chemical) 1.5 Part B Triethylhexanoin (Nippon Seika) 3.0 LUSPLAN SR-DM4 (Nippon Seika) 0.5 Hydrogenated polyisobutene 3.5 Isododecane 1.5 Cetostearyl alcohol 1.0 Alkali alcohol 0.1 Jojoba alcohol 3.0 Kimyl alcohol 0.3 Cerakill alcohol 0.1 Hexyldecanol 0.5 C part (Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate) Copolymer 0.2 Tremoist-TP (Nippon Fine Chemical) 0.03 Carbomer 0.1 Potassium hydroxide 0.2 Purified water 30.0 D part Neosolue-AquaS (Nippon Fine Chemical) 0.5 Polyquaternium-51 1.0 Composition of Example 4 1.0 Tranexamic acid (Nippon Seika) 2.0 Nicotinamide 5.0 Methylparaben 0.15 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A, B, and D were mixed separately and heated to approximately 70°C to uniformly dissolve and disperse. Part C was mixed in and stirred to form a viscous liquid. Part B was added to Part A while stirring in a homodisperser, then Part D was added and emulsified. The mixture was cooled to approximately 50°C, Part C was added, stirred, and cooled to approximately 40°C.

[0083] Example 22: Skincare Cream Component Amount (wt%) ------------------------------------- Part A Composition of Example 2 1.0 Sodium cyclic lysophosphatidic acid 0.01 Glycerin 9.0 DPG 5.0 Tripropylene glycol 2.0 Sucrose stearate 1.5 Part B (C13-15) Alkane 8.0 Vaseline 10.0 Pentaerythrityl tetraisostearate 5.0 Astaxanthin 0.01 Cetyl PG hydroxyethyl palmitamide 0.05 Dipentaerythrityl hexahydroxystearate 1.0 C part Carbomer 0.1 K hydroxide 0.07 Xanthan gum 0.1 Purified water 10.0 D part Phenoxyethanol 0.4 Ethylhexylglycerin 0.2 Methylparaben 0.05 Nicotinamide 5.0 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A, B, and D were mixed separately and heated to approximately 70°C to uniformly dissolve and disperse. Part C was mixed in and stirred to form a viscous liquid. Part B was added to Part A while stirring in a homodisperser, then Part D was added and emulsified. The mixture was cooled to approximately 50°C, Part C was added, stirred, and cooled to approximately 40°C.

[0084] Example 23: Skincare Cream Component Amount (wt%) ------------------------------------- Part A Sugar squalane 10.0 Stearic acid 1.0 Plandool-ISS (Nippon Fine Chemical) 1.0 Macadamia nut oil 3.0 Hydrogenated rapeseed alcohol 2.0 Cetearyl olivate 1.0 Olive oil fatty acid sorbitan 0.8 Polyglyceryl-10 oleate 1.0 Part B Acrylic acid / alkyl methacrylate copolymer 0.1 K hydroxide 0.07 (Acryloyldimethyltaurate ammonium / Beheneth-25 Methacrylate Crosspolymer 0.2 Tremoist-SL (Nippon Seika) 1.0 Purified water 20.0 Hydrolyzed polyγ-glutamic acid K 0.1 Sodium polyglutamate 0.1 Oligopeptide-24 0.05 C part PrimeLipid-PI (Nippon Fine Chemical) 1.0 Composition of Example 3 0.5 Propanediol 10.0 PEG-8 5.0 PEG-2M 2.0 Glyceryl caprylate 0.8 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A and C were mixed separately and heated to approximately 70°C to uniformly dissolve and disperse. Part B was added and stirred to form a viscous liquid. Part C was added to Part A while stirring with a homomixer and emulsified. After cooling to approximately 50°C, Part B was added and stirred, and the mixture was cooled to approximately 40°C.

[0085] Example 24: Skincare Cream Component Amount (wt%) ------------------------------------- Part A Plandool-MAS (Nippon Seika) 2.0 Plandool-LG1 (Nippon Seika) 1.0 Paraffin wax 3.0 Shea butter 3.0 Squalane 8.0 Cetanol 1.8 Hydrogenated Cocoglycerides 0.8 Glyceryl stearate 1.0 Behenyl alcohol 1.5 Sorbitan stearate 1.0 Polyglyceryl-10 laurate 1.0 PEG-60 Glyceryl Isostearate 1.0 Methyl glucose sesquistearate 1.5 Part B Xanthan gum 0.1 Hydroxyethylcellulose 0.1 Crystalline cellulose powder 0.3 Stearoxyhydroxypropylmethylcellulose 0.1 Tranexamic acid (Nippon Seika) 2.0 Purified water 20.0 C part Glycerin 8.0 DPG 5.0 Sorbitol 2.0 Composition of Example 1 2.5 Neosolue-Aqulio (Nippon Seika) 1.0 Methylparaben 0.15 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A and C were mixed separately and heated to approximately 70°C to uniformly dissolve and disperse. Part B was added and stirred to form a viscous liquid. Part C was added to Part A while stirring with a homomixer and emulsified. After cooling to approximately 50°C, Part B was added and stirred, and the mixture was cooled to approximately 40°C.

[0086] Example 25: Skincare Cream Component Amount (wt%) ------------------------------------- Part A Glycerin 12.0 BG 3.0 Phytocompo-PP (Nippon Fine Chemical) 2.5 Part B Olive fruit oil 3.0 Olive oil 1.5 Shea butter 1.0 Pentaerythrityl tetraethylhexanoate (Nippon Seika) 3.0 Sucrose stearate 0.8 Cetearyl glucoside 1.2 Behenyl alcohol 1.5 Ascorbyl tetrahexyldecanoate 7.0 Isopropyl lauroyl sarcosinate 2.0 Hydrogenated Cocoglycerides 3.0 Cetanol 2.5 Sorbitan stearate 0.8 C part Xanthan gum 0.05 Tremoist-SL (Nippon Seika) 1.0 Tuberose polysaccharide 0.01 Water-soluble collagen 0.05 Hydrolyzed collagen 0.5 Sodium pyrosulfite 0.03 Composition of Example 3 3.5 Arbutin (Nippon Seika) 1.0 Tranexamic acid (Nippon Seika) 1.0 Purified water 10.0 D part Neosolue-Aqulio (Nippon Seika) 1.0 Propanediol 3.0 Methylparaben 0.1 Glyceryl caprylate 1.0 Purified water, in an amount that totals 100. ------------------------------------- (Preparation method) Parts A, B, and D were mixed separately and heated to approximately 70°C to uniformly dissolve and disperse. Part C was mixed in and stirred to form a viscous liquid. Part B was added to Part A while stirring in a homodisperser, then Part D was added and emulsified. The mixture was cooled to approximately 50°C, Part C was added, stirred, and cooled to approximately 40°C.

[0087] Example 26: Skincare Cream Component Amount (wt%) ------------------------------------ Part A Neosolue-DiSM (Nippon Seika) 5.0 Jojoba oil 2.0 Plandool-H (Nippon Fine Chemical) 1.0 Neosolue-MCT (Nippon Seika) 3.0 LUSPLAN DD-DHR (Nippon Seika) 1.0 Plandool-SUN (Nippon Fine Chemical) 1.3 Propylene glycol stearate 0.6 Squalane 3.0 Behenyl alcohol 2.0 Liquid isoparaffin 0.5 Carnauba wax 0.3 Corn oil 0.3 Rapeseed oil 1.0 Sunflower oil 1.0 wheat germ oil 1.0 Flaxseed oil 0.1 Cottonseed oil 0.1 Soybean oil 0.1 Shea butter 0.5 Stigmasterol 1.0 Stigma 1.0 Dihydrocholesterol 0.1 Lanosterol 0.1 Dihydrolanosterol 0.1 Cholesteryl nonanoate 0.1 Cholesteryl stearate 0.1 Cholesteryl isostearate 1.0 Cholesteryl oleate 0.1 12-Cholesteryl hydroxystearate 0.1 Long-chain branched fatty acid cholesteryl 0.3 Octyldodecyl myristate 1.0 Octyldodecyl isostearate 1.0 Dimer dilinoleic acid hydrogenated castor oil 1.0 Hydroxyalkyl dimer dilinoleyl ether 1.0 Tetra(hydroxystearic acid / isostearate)dipentaerythrityl 0.5 Rice bran oil fatty acid phytosteryl 0.5 Phenylentrimethicone 1.0 Diphenyldimethicone 1.0 Methylhydrogenpolysiloxane 1.0 Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone 0.5 Dimethicone 50cs 0.3 Polyoxyethylene Methylpolysiloxane Copolymer 1.0 Ferulic Acid Tocopherol 0.1 Tocopherol Phosphate Ester 0.1 Tocotrienol 0.1 Tannin 0.01 Sesamin 0.01 Proanthocyanidin 0.01 Grapuridin 0.01 Grapuren 0.01 Licorice 0.01 Isolicorice 0.01 Lactoferrin 0.01 Gingerol 0.01 Zingerone 0.01 Part B (Acryloyldimethyl Taurine / Beheneth-25 Methacrylate) Copolymer 0.2 Crystalline Cellulose 0.1 Gellan Gum 0.1 Carboxyvinyl Polymer 0.1 Potassium Hydroxide 0.08 Purified Water 20.0 Part C Phytocompo-PP (Nippon Fine Chemical) 1.0 Composition of Example 1 0.5 Polyglyceryl-10 Stearate 0.5 Glycerin 7.0 DPG 7.0 Part D Citric Acid 0.07 Sodium Citrate Appropriate Amount EDTA-2Na 0.05 Pentetate 5Na 0.03 Phenoxyethanol 0.4 Purified Water An Amount That Totals 100 -------------------------------------- (Preparation method) Part A was mixed and heated to approximately 70°C to dissolve uniformly. Part B was mixed and stirred to form a viscous liquid. Part C was mixed and heated to approximately 70°C to disperse uniformly. Part D was mixed and heated to approximately 70°C to dissolve uniformly. Part A was added to Part C while stirring with a homogenizer, then Part D was added and emulsified. After cooling to approximately 50°C, Part B was added and stirred to dissolve uniformly.

[0088] Example 27: Skincare Cream Component Amount (wt%) -------------------------------------- Part A Plandool-G (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Seika) 1.5 Diethylhexyl sebacate (Nippon Seika) 8.0 Diisopropyl sebacate (Nippon Seika) 2.0 Theobroma grandiflorum seed butter 3.0 Batyl isostearate 2.0 Shea butter 3.0 (Dimethicone / Vinyl Dimethicone) Crosspolymer 0.3 (Vinyl dimethicone / Lauryl dimethicone) crosspolymer 0.5 (Dimethicone / PEG-10 / 15) Crosspolymer 0.5 (PEG-15 / Lauryl Dimethicone) Crosspolymer 0.2 (Alkyl acrylate / dimethicone) copolymer 0.1 Isostearyl pivalate 0.1 Pentaerythrityl tetraethylhexanoate (Nippon Seika) 0.1 Stearyl alcohol 3.5 Cetanol 1.3 Coconut fatty acid sucrose 1.0 Polyglyceryl-3 Methylglucose Distearate 0.8 Glyceryl Trifatty Acid (C10-18) 3.0 Squalane 3.0 Dimethicone 100cs 1.0 Tocopherol 0.1 Ascorbyl Tetrahexyldecanoate 8.0 Tocopheryl Ascorbyl Phosphate 2.0 Placenta Extract 1.0 Oryzanol 0.3 Phytosphingosine 0.0001 Coenzyme Q10 0.03 Carotene 0.05 Lycopene 0.01 Astaxanthin 0.01 Lutein 0.01 Fullerene 0.001 Peanut Oil 0.1 Rice Bran Oil 1.0 Hydrogenated Castor Oil 0.3 Jojoba Oil 2.0 Orange Raffia Oil 1.0 Liquid Lanolin (Nippon Seika) 1.0 Lanolin (Nippon Seika) 1.0 Polyoxyethylene Lanolin 1.0 Lanolin Alcohol (Nippon Seika) 0.3 Lanolin Alcohol Acetate 0.1 Cholesteryl Acetate 0.1 Octocrylene 0.5 Sorbitan Sesquistearate 1.2 Part B Tremoist-TP (Nippon Seika) 0.05 Water-Soluble Collagen 0.05 Hydrolyzed Collagen 0.5 Glutathione 0.3 Arbutin (Nippon Seika) 3.0 Nicotinamide 5.0 Part C Composition of Example 2 1.0 Propanediol 10.0 PPG-9 Diglyceryl 2.0 Diglycerin 1.0 Sodium pyrosulfite 0.1 Imidazolinium urea 0.1 Polyvinylpyrrolidone 0.1 Pullulan 0.1 Polyvinyl alcohol 0.1 Dehydroacetic acid 0.1 PEG-32 1.0 Polyglycerin-10 1.0 Pentasodium pentetate 0.05 Phenoxyethanol 0.4 1,2-Pentanediol 2.0 Succinic acid 0.05 Sodium succinate (appropriate amount) Purified water, in an amount that totals 100. -------------------------------------- (Preparation method) Part A was heated to approximately 70°C and dissolved uniformly. Part B was homogenized using some purified water. Part C was heated to approximately 70°C and dispersed. While stirring with a homomixer at approximately 70°C, Part A was gradually added to Part C and emulsified. After cooling to approximately 40°C, Part B was added and mixed uniformly, and the pH was adjusted to 6.5-7.0 with sodium succinate.

[0089] Example 28 Emulsion Component Amount (wt%) -------------------------------- Part A Phytocompo-SP (Nippon Fine Chemical) 10.0 Lysolecithin (Nippon Seika) 0.1 Composition of Example 2 3.5 Part B Squalane 4.0 Neosolue-MCT (Nippon Seika) 4.0 α-olefin oligomer 2.5 Dimethicone 5cs 3.5 Cetanol 1.5 Glyceryl stearate 1.0 C part Hydroxyproline 0.05 Citric acid 0.01 Sodium citrate 0.09 Arbutin (Nippon Seika) 3.0 Phenoxyethanol 0.3 Methylparaben 0.1 Acrylic acid / alkyl methacrylate copolymer 0.1 K hydroxide 0.1 Purified water, in an amount that totals 100. ----------------------------------- (Preparation method) Parts A, B, and C were each taken and heated to approximately 70°C, then mixed uniformly. Part B was gradually added to part A while stirring with a homodisperser, and then part C was added at approximately 70°C and emulsified. After that, it was cooled to approximately 40°C.

[0090] Example 29: Cleansing Gel Component Amount (wt%) --------------------------------- Part A Composition of Example 2 2.5 1,2-Pentanediol 1.0 Cetyl ethylhexanoate (Nippon Seika) 10.0 Plandool-S (Nippon Fine Chemical) 1.0 Dihydrocholeth-30 (Nippon Seika) 2.0 LUSPLAN DD-IS (Nippon Fine Chemical) 8.0 PEG-25 Hydrogenated Castor Oil 20.0 Octyldodeceth-20 15.0 Glycerin 16.0 BG 5.0 Part B Phenoxyethanol 0.5 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) Part A was heated to approximately 80°C and dissolved. Part B was heated to approximately 80°C. Part B was gradually added to Part A while stirring, and after mixing, it was cooled to 40°C.

[0091] Example 30: Cleansing Cream Component Amount (wt%) --------------------------------- Part A Plandool-LG2 (Nippon Seika) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Ceresin 6.0 Composition of Example 2 0.5 PEG-12 Isostearate 3.0 Sorbitan sesquioleate 1.5 Polyoxyethylene sorbitan oleate 0.3 Polyglyceryl-10 laurate 0.3 Microcrystalline wax 2.0 Tocopherol 0.05 Part B Neosolue-Aqua (Nippon Fine Chemical) 0.5 DPG 5.0 EDTA 3Na 0.02 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) Part A was heated to approximately 80°C and dissolved. Part B was heated to approximately 80°C. Part B was gradually added to Part A while stirring, and after mixing, it was cooled to 40°C.

[0092] Example 31: Facial Cleansing Foam Component Amount (wt%) --------------------------------- Part A Composition of Example 2 1.0 (Coconut fatty acid / hydrogenated beef tallow fatty acid) sodium glutamate 30.0 Cocoyl glycine K 5.0 Plandool-LG2 (Nippon Seika) 0.2 Lauric acid diethanolamide 3.0 Tocopherol 0.1 PEG-8 5.0 PEG-32 10.0 Glycerin 14.0 Part B Glyceryl caprylate 1.0 Hexanediol 1.0 Polyquaternium-51 1.0 Tremoist-SL (Nippon Seika) 0.5 Crystalline cellulose 0.3 Polyquaternium-7 0.8 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) Part A was heated to approximately 80°C and dissolved. Part B was heated to approximately 80°C. Part B was gradually added to Part A while stirring, and after mixing, it was cooled to 40°C.

[0093] Example 32: Body Shampoo Component Amount (wt%) --------------------------------- Composition of Example 2 1.0 Sodium Cocoyl Methyl Taurate 10.0 Sodium Lauroyl Hydrolyzed Silk 6.0 Sodium lauroyl methylalanine 10.0 Sodium cocoamphoacetate (30%) 4.0 Cocamidopropyl betaine (30%) 10.0 Sodium olefin (C14-16) sulfonate 5.0 Polyquaternium-10 1.3 Guar hydroxypropyltrimonium chloride 0.8 Sodium acetylated hyaluronate 0.02 Cocamide DEA 3.0 Glycerin 5.0 Methylparaben 0.2 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) All ingredients were heated to approximately 80°C and stirred until uniform.

[0094] Example 33: Non-silicone shampoo Component Amount (wt%) --------------------------------- Composition of Example 4 1.0 Plandool-LG2 (Nippon Seika) 0.03 Neosolue-AquaS (Nippon Fine Chemical) 0.1 Tremoist-SL (Nippon Seika) 0.5 Sodium laureth-4 carboxylate (28%) 10.0 Laureth-6 carboxylic acid 4.0 Cocamidopropyl betaine (30%) 10.0 Sodium Lauroyl Methylalanine (30%) 5.0 Cocamide methyl MEA 3.0 PEG-7 Glyceryl Cocoate 5.0 Sodium hydroxide 1% solution 0.5 Polyquaternium-10 0.8 Glycol distearate 0.5 Polyquaternium-7 0.5 EDTA-2Na 0.05 Phenoxyethanol 0.4 Sodium benzoate 0.2 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) All ingredients were heated to approximately 80°C and stirred until uniform.

[0095] Example 34: Hand soap Component Amount (wt%) -------------------------------- Part A Sodium cocoyl isethionate 1.0 Glycerin 50.0 Composition of Example 2 1.0 Part B Sodium lauroyl sarcosinate 12.0 Sodium myristoylmethyltaurate 2.0 Polyglyceryl-6 laurate 2.0 Coconut oil fatty acid diethanolamide 2.0 PEG-7 Coconut Oil Fatty Acid Glyceryl 2.0 Sorbitol 8.0 Hydrolyzed conchiolin 0.1 1,3-Butylene glycol 8.0 Phenoxyethanol 0.8 Ethanol 3.0 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) Part A was heated to approximately 80°C and dissolved. Part B was added to Part A, heated to approximately 80°C, uniformly dissolved, and then cooled.

[0096] Example 35: Leave-in hair treatment Component Amount (wt%) ------------------------------------- Part A Composition of Example 2 1.0 Polyquaternium-37 2.0 Squalane 2.0 PPG-3 Caprylyl Ether 2.0 Microcrystalline wax 0.1 Lanolin alcohol 0.2 Montan Wax 0.1 Polyethylene wax 0.1 Woodrow 0.2 Ceresin 0.1 PG dicaprate 1.0 Almond oil 0.5 Ethylhexyl ethylhexanoate 1.0 Candelilla wax extract 0.1 Octyldodecyl erucate 4.5 Tocopherol acetate 0.02 Elcalactone MCT (Nippon Seika) 2.0 Dipentaerythrityl tripolyhydroxystearate 1.5 PPG-5 Phytosteryl 0.5 Glycerin 4.0 Sorbitol 2.0 Phenoxyethanol 0.5 Part B Hydrolyzed hyaluronic acid 0.1 Panthenol 0.1 Hydroxypropyltrimonium hyaluronate 0.01 Polyquaternium-11 0.2 Glycosyltrehalose 0.1 Glyceryl glucoside 0.3 Arginine 0.1 C part Purified water, in an amount that totals 100. Hydroxypropyl starch phosphate 1.0 -------------------------------------- (Preparation method) Part C was uniformly dispersed and heated to approximately 80°C. Next, Part A was heated to approximately 80°C and dissolved. Part A was added to Part C while stirring, and after uniform mixing, it was cooled to approximately 40°C. Then, Part B was added to each and mixed uniformly.

[0097] Example 36: Leave-in scalp / hair treatment Component Amount (wt%) -------------------------------------- Part A Composition of Example 2 1.5 Neosolue-Aqulio (Nippon Seika) 1.0 Ethanol 40.0 Glycyrrhetinic acid 0.02 Elcalactone DES (Nippon Seika) 1.5 PEG / PPG-20 / 20 Dimethicone 0.2 PEG-12 Dimethicone 0.4 Hydrogenated retinol 0.1 Pyridoxine trishexyldecanoate 0.05 Bisglyceryl ascorbate 0.3 Hexyl 3-glyceryl ascorbate 0.3 Part B Triethanolamine 0.1 Purified water, in an amount that totals 100. (Acrylates / C10-30 Alkyl Acrylate) Crosspolymer 0.4 Carbomer 0.05 Tremoist-SL (Nippon Seika) 1.0 (Acryloyldimethyltaurate Ammonium / VP) Copolymer 0.05 (Acryloyldimethyltaurate ammonium / Beheneth-25 Methacrylate Crosspolymer 0.1 Hydroxypropyl chitosan 0.1 Methylparaben 0.1 Phenoxyethanol 0.2 C part 3-O-ethyl ascorbic acid (Nippon Seika) 0.3 Nicotinamide 0.3 Pyridoxine hydrochloride 0.1 Caffeine 0.1 Glucosyltrehalose 0.1 Purified water 10.0 -------------------------------------- (Preparation method) Part A was heated to approximately 50°C and dissolved. Next, Part B was uniformly dispersed to form a viscous liquid. Part A was added to Part B while stirring and mixed uniformly. Then Part C was added and mixed uniformly.

[0098] Example 37: Shampoo Component Amount (wt%) -------------------------------- Part A Composition of Example 2 3.0 PPG-3 Caprylyl Ether 0.2 Ammonium laureth sulfate 5.0 Sodium laureth sulfate (25%) 10.0 Lauryl hydroxysultaine (30%) 10.0 Potassium laurate 1.0 Glycol distearate 0.5 Toluene sulfonic acid 0.3 Stearoxypropyldimethylamine 0.5 PPG-17 0.3 Dimethicone 0.1 PEG-9 Dimethicone 0.1 Amodimethicone 0.1 Diethylhexyl sebacate (Nippon Seika) 1.0 Neopentyl glycol diethylhexanoate 0.4 Lanolin fatty acid 0.3 Isodecyl glyceryl ether 0.4 Miconazole nitrate 0.75 Cocamide MEA 1.0 Laureth-4 0.3 Laureth-16 0.2 Steerless-6 0.2 Phenoxyethanol 0.3 Part B Malic acid 0.1 Methylparaben 0.2 Phosphate 0.03 Sodium benzoate 0.3 Arginine 0.4 Purified water, in an amount that totals 100. C part Polyquaternium-10 0.2 Guar hydroxypropyltrimonium chloride 0.1 Tremoist-SL (Nippon Seika) 3.0 Purified water 6.7 -------------------------------- (Preparation method) Part A was uniformly mixed at approximately 80°C. Part B, which had been set aside, was heated to approximately 60°C and made uniform. Part B was gradually added to Part A while stirring, and after it was uniformly mixed, it was cooled to approximately 50°C. Part C was then added and uniformly mixed.

[0099] Example 38: Leave-on hair treatment Component Amount (wt%) -------------------------------- Part A Composition of Example 2 1.0 Neosolue-Aqulio (Nippon Seika) 2.0 Cetanol 3.8 Caprylyl glucoside (50%) 1.5 Glycerin 4.0 Phenoxyethanol 0.5 Part B Ethanol 5.0 C part Polyquaternium-6 0.6 Polyquaternium-7 0.4 Polyquaternium-39 0.5 Purified water, in an amount that totals 100. -------------------------------- (Preparation method) Part C was heated to approximately 80°C and dissolved. Next, Part A was heated to approximately 80°C and dissolved. Part A was added to Part C while stirring, and after uniform mixing, it was cooled to approximately 40°C. Then, Part B was added and uniform mixing was performed.

[0100] Example 39 Lipstick Component Amount (wt%) --------------------------------- Composition of Example 2 0.5 LUSPLAN SR-DM4 (Nippon Seika) 7.0 Hydrogenated polyisobutene 5.0 Triethylhexanoin (Nippon Seika) 10.0 Neosolue-MCT (Nippon Seika) Amount that totals 100 Dialkyl carbonate (C14, 15) 3.0 Dextrin palmitate 0.9 Sodium stearoyl lactate 0.9 Cetyl ethylhexanoate (Nippon Seika) 24.0 Dimethicone 50cs 5.0 Plandool-MAS (Nippon Seika) 2.0 Ceresin 8.5 Candelilla Raw 4.0 Sorbitan sesquioleate 0.15 Hydrogen dimethicone 2.0 Ethanol 0.1 Tocopherol 0.5 Nylon-12 2.0 (Ethylene / Propylene) Copolymer 0.5 Barium sulfate 1.0 Iron oxide 2.0 Mica 2.0 Titanium dioxide 1.0 --------------------------------- (Preparation method) After uniformly heating, stirring, and mixing all the ingredients, the mixture was filled into molds and rapidly cooled.

[0101] Example 40: Lip balm Component Amount (wt%) --------------------------------- Plandool-H (Nippon Fine Chemical) 10.0 Plandool-LG3 (Nippon Seika) 5.0 Polyglyceryl-2 diisostearate 15.0 Composition of Example 2 4.0 Squalane: an amount that totals 100 12-Hydroxystearic acid 5.0 Silylated silica 3.0 Menthol 0.5 Fragrance (appropriate amount) Antioxidant (appropriate amount) --------------------------------- (Preparation method) All ingredients were heated to approximately 90°C, mixed uniformly, and then cooled.

[0102] Example 41 Foundation Component Amount (wt%) -------------------------------- Plandool-S (Nippon Fine Chemical) 1.0 Plandool-G (Nippon Fine Chemical) 0.1 Plandool-SUN (Nippon Fine Chemical) 0.1 Plandool-MAS (Nippon Seika) 0.1 Plandool-ISS (Nippon Fine Chemical) 0.1 Composition of Example 4 2.0 Cyclomethicone 3.5 Trimethylsiloxysilicate 1.5 Talc 24.0 Iron oxide 1.9 Titanium dioxide 20.0 Tocopherol 0.1 Ethylhexyl methoxycinnamate 1.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Phenoxyethanol 0.4 Amount of mica that totals 100 -------------------------------- (Preparation method) All ingredients were stirred and mixed uniformly before being molded.

[0103] Example 42: Solid powder foundation Component Amount (wt%) --------------------------------- Part A Plandool-H (Nippon Fine Chemical) 2.0 YOFCO MAC (Nippon Seika) 0.1 Plandool-LG1 (Nippon Seika) 0.1 Plandool-LG2 (Nippon Seika) 0.1 Plandool-LG4 (Nippon Seika) 0.1 LUSPLAN PI-DA (Nippon Fine Chemical) 3.0 Cetyl ethylhexanoate (Nippon Seika) 3.0 Composition of Example 2 3.0 Squalane 1.6 Part B Lecithin-treated sericite 20.0 Boron nitride 10.0 Mica 3.0 Silica 2.0 Dimethicone 3.0 Nylon-12 3.0 Talc 10.0 Titanium dioxide 10.0 Amount of iron oxide that totals 100 --------------------------------- (Preparation method) Part A was heated and mixed. Part B was placed in a separate container and mixed and dispersed. Part A was added to Part B, mixed uniformly, and then molded.

[0104] Example 43: Liquid Foundation Component Amount (wt%) --------------------------------- Part A Composition of Example 2 7.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Octyltriazone 1.5 Ethylhexyl methoxycinnamate 1.0 Quaternium-18 hectorite 0.5 Part B Cyclomethicone 25.0 Polyether-modified silicone mixture 5.0 (Manufactured by Toray Dow Corning Silicone Co., Ltd., BY22-008M) Polyglyceryl-2 isostearate 1.0 Titanium oxide / iron oxide mixture 12.5 Mica 6.0 C part Glycerin 5.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Methylparaben 0.2 Tranexamic acid (Nippon Seika) 2.0 Purified water, in an amount that totals 100. --------------------------------- (Preparation method) Part A was heated to approximately 80°C and thoroughly dispersed. Part B, also heated to approximately 80°C, was added to this, and then Part C, further heated to approximately 80°C, was added. The mixture was emulsified and dispersed using a homogenizer, and then stirred and cooled to room temperature.

[0105] Example 44 Foundation Component Amount (wt%) ------------------------------------ Part A Composition of Example 2 1.0 Isododecane 10.0 Neosolue-MCT (Nippon Seika) 4.0 Ethylhexyl Methoxycinnamate 3.0 Plandool-SUN (Nippon Fine Chemical) 1.0 Plandool-LG2 (Nippon Seika) 1.0 Plandool-LG4 (Nippon Seika) 1.0 Vaseline 1.0 Isotridecyl isononanoate 2.0 Ascorbyl tetrahexyldecanoate 0.1 Dextrin palmitate 0.3 Sorbitan isostearate 1.5 Tribehenin 0.5 (butyl acrylate / glycol dimethacrylate) crosspolymer, silica, (Methyl methacrylate / glycol dimethacrylate) crosspolymer mixture 2.0 Boron nitride 1.0 Polysorbate 20 2.0 PEG-60 Hydrogenated Castor Oil 1.0 Disteardimonium hectorite (20%) 2.5 Polypropylsilsesquioxane and cyclopentasiloxane mixture 1.0 Mica 15.0 Talc 4.0 Zinc oxide 5.0 Titanium dioxide 10.0 Iron oxide 1.5 Part B Amount of water that totals 100 DPG 4.0 Maltitol (75% solution) 1.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Sodium chloride 1.0 BG 1.0 Tremoist-SL (Nippon Seika) 1.0 Ethanol 0.5 Phenoxyethanol 0.3 ------------------------------------ (Preparation method) Part A was heated to approximately 70°C and thoroughly stirred to ensure uniform dispersion. Part B was heated to approximately 70°C and made uniform, then Part B was added to Part A, stirred at approximately 70°C to emulsify, and cooled to approximately 40°C.

[0106] Example 45: Sunscreen Cosmetic Component Amount (wt%) ----------------------------------- Part A FINEX-33W (Sakai Chemical Industry) 5.0 STR-100W (Sakai Chemical Industry) 5.0 Purified water, in an amount that totals 100. BG 7.0 Disodium edetate 0.05 Triethanolamine 1.0 Part B Oxybenzone 3.0 Octyl paramethoxycinnamate 5.0 t-Butylmethoxybenzoylmethane 3.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Composition of Example 2 3.0 Diethylhexyl sebacate (Nippon Seika) 8.0 Plandool-H (Nippon Fine Chemical) 2.0 Plandool-SUN (Nippon Fine Chemical) 2.0 Plandool-MAS (Nippon Seika) 0.1 Plandool-LG1 (Nippon Seika) 0.1 Plandool-LG2 (Nippon Seika) 0.1 Plandool-LG3 (Nippon Seika) 0.1 Plandool-LG4 (Nippon Seika) 0.1 LUSPLAN PI-DA (Nippon Fine Chemical) 3.0 Cetyl ethylhexanoate (Nippon Seika) 3.0 Diisopropyl sebacate (Nippon Seika) 5.0 Dimethicone 2cs 5.0 Sucrose stearate 1.5 Polyglyceryl-10 stearate 2.0 Stearyl alcohol 3.0 Batyl alcohol 1.0 Stearic acid 3.0 Glyceryl monostearate 3.0 Ethyl polyacrylate 1.0 Phenoxyethanol 0.5 ----------------------------------- (Preparation method) Part A was heated to approximately 80°C and thoroughly dispersed. Part B, also heated to approximately 80°C, was added to this, and the mixture was emulsified and dispersed using a homogenizer, then stirred and cooled to room temperature.

[0107] Example 46: Sunscreen Cosmetic Component Amount (wt%) ----------------------------------- Part A BG 10.0 Glycerin 9.0 Phytocompo-PP (Nippon Fine Chemical) 1.0 Octocrylene 4.0 Octyl salicylate 4.0 Diethylamino hydroxybenzoyl hexyl benzoate 2.25 t-Butyl methoxydibenzoylmethane 1.0 Diethylhexyl sebacate (Nippon Seika) 3.0 Pentaerythrityl tetraethylhexanoate (Nippon Seika) 2.0 Diisopropyl sebacate (Nippon Seika) 1.0 Behenyl alcohol 2.0 Cetearyl alcohol 2.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol 0.05 Part B Neosolue-AquaS (Nippon Fine Chemical) 1.0 Methylparaben (appropriate amount) Amount of water that totals 100 C part Carbomer (2%) 5.0 Tremoist-SL (Nippon Seika) 10.0 DIS-AB-10W (Sakai Chemical Industry) 5.0 Composition of Example 2 0.2 ----------------------------------- (Preparation method) Heat and dissolve parts A and B separately at approximately 70°C. Gradually add part B to part A and emulsify. Cool while stirring, and mix in part C at 45°C.

[0108] Example 47 Cosmetic Oil Component Amount (wt%) -------------------------------- Neosolue-DiSM (Nippon Seika) Amount that totals 100 Composition of Example 2 2.0 PrimeLipid-PI (Nippon Fine Chemical) 1.0 Octyldodecanol 40.0 Plandool-LG2 (Nippon Seika) 3.0 Ceramide 2 1.0 Ceramide 5 1.0 Cholesterol 5.0 Preservative (appropriate amount) -------------------------------- (Preparation method) All ingredients were stirred and mixed at approximately 90°C, and then allowed to cool.

[0109] In the above formulation, the details of the ingredients listed under the product name are as follows: Plandool-H: Dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Plandool-S: Dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Plandool-G: Dimer dilinoleyl dimer dilinoleate bis(behenyl / isostearyl / phytosteryl) Plandool-DP: Bis-diglyceryl polyacyladipate-2 Plandool-ISS: Phytosteryl isostearate Plandool-SUN: Phytosteryl sunflower seed oil fatty acids Plandool-MAS: Macadamia nut oil fatty acid phytosteryl Plandool-LG1: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) Plandool-LG2: Lauroyl glutamate di(phytosteryl / octyldodecyl) Plandool-LG3: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) Plandool-LG4: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) 〇LUSPLAN DD-IS: Dimer Dilinoleyl Diisostearate 〇LUSPLAN PI-DA: Dimer dilinoleate di(isostearyl / phytosteryl) LUSPLAN DD-DHR: Dimer Dilinoleyl Hydrogenated Rosin Condensate LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, Caprylic / Capric triglyceride Neosolue-Aqulio: Bisethoxydiglycol Cyclohexanedicarboxylic Acid 〇Neosolue-Aqua: (Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10, Glycerin 〇Neosolue-AquaS: (Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10, Glycerin 〇Neosolue-DiSM: Diisostearyl malate Neosolue-MCT: ​​Caprylic / Capric Triglyceride 〇Phytocompo-PP: Hydrogenated lecithin, phytosterols 〇Phytocompo-C: Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II Phytocompo-SP: Hydrogenated lecithin, phytosterols, BG, glycerin 〇Phytopresome MEL: Glycolipids, hydrogenated lecithin, BG, purified water 〇Elcalactone MCT: γ-Docosalactone, Caprylic / Capric Triglyceride 〇 Elcalactone DES: γ-docosalactone, diethyl sebacate Tremoist-TP: Tremella fuciformis polysaccharide 〇Tremoist-SL: Tremella fuciformis polysaccharide aqueous solution (1%) YOFCO MAC: Macadamia nut oil fatty acid cholesteryl PrimeLipid-PI: Hydrogenated lecithin, phytosterols, lecithin, tocopherols STR-100W: Titanium dioxide, hydrated silica FINEX-33W: Zinc oxide, hydrated silica 〇DIS-AB-10W: Titanium dioxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone

Claims

1. A composition for cosmetics or external skin preparations containing the following components (A) to (C), wherein the content of component (A) is 1 to 35% by mass, the content of component (B) is 61.5 to 99.89% by mass, and the content of component (C) is 0.01 to 3.5% by mass. (A) Lysolecithin containing lysophosphatidic acid (B) Polyhydric alcohols (C) One or more selected from polyvalent metal hydroxides, oxides, and chlorides

2. The composition according to claim 1, characterized in that component (A) contains 15% by mass or more of lysophosphatidic acid.

3. The composition according to claim 1 or 2, characterized in that component (B) contains 50% by mass or more of glycerin.

4. The composition according to any one of claims 1 to 3, characterized in that the polyvalent metal of component (C) is selected from zinc, aluminum, calcium, barium, magnesium, and iron.

5. The composition according to any one of claims 1 to 4, characterized in that the polyvalent metal of component (C) is zinc or aluminum.

6. A cosmetic or topical skin preparation containing the composition described in any one of claims 1 to 5.

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