Protein removal composition and method for producing the same

Abstract

Provided is a composition for removing protein which meets sewage disposal standards. More specifically, provided is a composition for removing protein comprising at least one substance selected from the group consisting of: organic acids and / or salts thereof; and organic peroxy acids and / or salts thereof, said composition having a pH value of 4.0-10.0.

Description

Technical Field

[0001] The present invention relates to a composition for removing proteins suitable for sterilizing and cleaning medical devices, and a method for producing the same.

Background Art

[0002] Conventionally, acidic or alkaline chemicals have been used for sterilizing and cleaning medical devices, and an aqueous peracid solution is one of them. However, since acidic or alkaline chemicals are used, their waste liquids are discharged without meeting the sewage discharge standards, and there are many examples of damage to concrete sewer pipes. Damage to sewer pipes can not only prevent sewage from being discharged but also cause road subsidence, and urgent countermeasures are required. Under such circumstances, the Tokyo Metropolitan Sewerage Bureau announced a warning about dialysis drainage and sewer pipes in January 2019. The Tokyo Metropolitan Sewerage Bureau requires that the sewage discharge standards for drainage be within the range where the hydrogen ion concentration (pH) exceeds 5 and is less than 9.

[0003] As compositions for sterilizing and cleaning used for sterilizing and cleaning medical devices, an acidic peracetic acid aqueous solution (Patent Document 1), an acidic oxidant-containing composition having aluminum corrosion inhibition properties (Patent Document 2), an alkaline cleaning preparation (Patent Document 3), etc. are known. However, these compositions do not necessarily meet the sewage discharge standards for drainage. In addition, in the cleaning of medical devices, it is necessary to remove proteins adhering to used medical devices, but these compositions do not have sufficient protein removal power. Therefore, there is still a need for a cleaning agent that does not damage the water distribution pipes and has sufficient protein removal power.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

[0005] There is a need for a protein removal composition that ensures wastewater meets sewage discharge standards. [Means for solving the problem]

[0006] As a result of diligent research, the inventors have found that they can provide a protein removal composition that ensures wastewater meets sewage discharge standards.

[0007] In other words, the present invention includes the following embodiments. <1> It comprises one or more selected from the group consisting of organic acids and / or salts thereof, and perorganic acids and / or salts thereof, The pH value is between 4.0 and 10.0. A composition for protein removal. <2> The protein removal composition according to claim 1, wherein the pH value is 5 or higher. <3> The protein removal composition according to claim 1 or 2, wherein the organic acid is selected from acetic acid, citric acid, and malic acid. <4> The protein removal composition according to any one of claims 1 to 3, wherein the perorganic acid is peracetic acid. <5> The protein removal composition according to any one of claims 1 to 4, comprising the aforementioned organic acid and / or a salt thereof in an amount of 0.1 to 70% by mass. <6> The protein removal composition according to any one of claims 1 to 5, comprising the aforementioned perorganic acid and / or a salt thereof in an amount of 0.001 to 15% by mass. <7> Furthermore, the protein removal composition according to any one of claims 1 to 6, comprising persulfate and / or a salt thereof. <8> The protein removal composition according to claim 7, wherein the persulfate is selected from ammonium persulfate, sodium persulfate, potassium persulfate, and oxone (2KHSO5·KHSO4·K2SO4). <9> The protein removal composition according to claim 7 or 8, wherein the persulfate and / or salt thereof is contained in an amount of 0.01 to 60% by mass. <10> A protein removal dilution composition comprising the protein removal composition according to any one of claims 1 to 9 and water. <11> The protein removal dilution composition according to claim 10, comprising the aforementioned organic acid and / or a salt thereof in an amount of 0.01 to 10% by mass. <12> The protein removal dilution composition according to claim 10 or 11, wherein the perorganic acid and / or salt thereof is contained in an amount of 0.0001 to 0.1% by mass. <13> The protein removal dilution composition according to any one of claims 10 to 12, comprising the persulfate and / or salt thereof in an amount of 0.001 to 1% by mass. [Effects of the Invention]

[0008] According to the present invention, a protein removal composition can be provided in which the wastewater meets the sewage discharge standards. The composition of the present invention has a pH value that meets the sewage discharge standards, so the wastewater after use can be discharged without the need for neutralization treatment, and it has sufficient protein removal power. [Modes for carrying out the invention]

[0009] 1. Composition for protein removal In one embodiment of the present invention, the protein removal composition comprises one or more selected from the group consisting of organic acids and / or salts thereof, and perorganic acids and / or salts thereof.

[0010] In one embodiment of the present invention, the protein removal composition may have a pH value of 4.0 to 10.0. In one embodiment of the present invention, the pH value of the protein removal composition may be, for example, 4.0, 4.5, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, etc., but is not limited to these values. In one embodiment of the present invention, the pH value of the protein removal composition may be, for example, 4.0 to 10.0, 4.0 to 9.5, 4.0 to 9.0, 4.0 to 8.5, 4.0 to 8.0, 4.0 to 7.5, 4.0 to 7.0, 4.0 to 6.5, 4.0 to 6.0. In one embodiment of the present invention, the pH value of the protein removal composition may be 4.5 to 10.0, 4.5 to 9.5, 4.5 to 9.0, 4.5 to 8.5, 4.5 to 8.0, 4.5 to 7.5, 4.5 to 7.0, 4.5 to 6.5, or 4.5 to 6.0. In another embodiment of the present invention, the pH value of the protein removal composition may be 5.0 to 10.0, 5.0 to 9.5, 5.0 to 9.0, 5.0 to 8.5, 5.0 to 8.0, 5.0 to 7.5, 5.0 to 7.0, 5.0 to 6.5, or 5.0 to 6.0. In one embodiment of the present invention, the pH value of the protein removal composition may be 5.1 to 10.0, 5.1 to 9.5, 5.1 to 9.0, 5.1 to 8.5, 5.1 to 8.0, 5.1 to 7.5, 5.1 to 7.0, 5.1 to 6.5, or 5.1 to 6.0. In another embodiment of the present invention, the pH value of the protein removal composition may be 5.2 to 10.0, 5.2 to 9.5, 5.2 to 9.0, 5.2 to 8.5, 5.2 to 8.0, 5.2 to 7.5, 5.2 to 7.0, 5.2 to 6.5, or 5.2 to 6.0. In one embodiment of the present invention, the pH value of the protein removal composition may be 5.3 to 10.0, 5.3 to 9.5, 5.3 to 9.0, 5.3 to 8.5, 5.3 to 8.0, 5.3 to 7.5, 5.3 to 7.0, 5.3 to 6.5, or 5.3 to 6.0. In another embodiment of the present invention, the pH value of the protein removal composition may be 5.4 to 10.0, 5.4 to 9.5, 5.4 to 9.0, 5.4 to 8.5, 5.4 to 8.0, 5.4 to 7.5, 5.4 to 7.0, 5.4 to 6.5, or 5.4 to 6.0.In one embodiment of the present invention, the pH value of the protein removal composition may be 5.5 to 10.0, 5.5 to 9.5, 5.5 to 9.0, 5.5 to 8.5, 5.5 to 8.0, 5.5 to 7.5, 5.5 to 7.0, 5.5 to 6.5, 5.5 to 6.0. In a preferred embodiment of the present invention, the pH value of the protein removal composition is 5.0 or more. In a preferred embodiment of the present invention, the pH value of the protein removal composition is 5 or more and 10 or less. In another preferred embodiment of the present invention, the pH value of the protein removal composition is 5 or more and 9 or less. In another preferred embodiment of the present invention, the pH value of the protein removal composition is more than 5 and less than 9.

[0011] In one embodiment of the present invention, the protein removal composition contains one or more selected from the group consisting of an organic acid and / or its salt, and a peroxy organic acid and / or its salt. The pH value of the composition may be 4.0 to 10.0.

[0012] In one embodiment of the present invention, the above protein removal composition may further contain persulfuric acid and / or its salt.

[0013] Hereinafter, each component will be described.

[0014] By including one or more selected from the group consisting of an organic acid and / or its salt, and a peroxy organic acid and / or its salt, the protein removal composition of the present invention can adjust the pH value of the protein removal composition to 4.0 to 10.0. In one embodiment of the present invention, the protein removal composition may contain an organic acid and / or its salt. In another embodiment of the present invention, the protein removal composition may contain a peroxy organic acid and / or its salt. In yet another embodiment of the present invention, the protein removal composition may contain an organic acid and / or its salt, and a peroxy organic acid and / or its salt.

[0015] (1) Organic acid and / or its salt Organic acids and / or salts thereof that can be used in the protein removal composition of the present invention include, but are not limited to, carboxylic acids such as acetic acid and / or salts thereof, citric acid and / or salts thereof, malic acid and / or salts thereof, lactic acid and / or salts thereof, succinic acid and / or salts thereof, glutaric acid and / or salts thereof, 2-hydroxyisobutyric acid and / or salts thereof, propionic acid and / or salts thereof, butanoic acid and / or salts thereof, pentanoic acid and / or salts thereof, hexanoic acid and / or salts thereof, heptanoic acid and / or salts thereof, and octanoic acid and / or salts thereof. In one embodiment of the present invention, the organic acid and / or salt thereof can be selected from acetic acid and / or salts thereof, citric acid and / or salts thereof, and malic acid and / or salts thereof. Organic acids and / or salts thereof that are commonly used in the art can be used in the protein removal composition of the present invention. In a preferred embodiment of the present invention, the organic acid and / or salt thereof may be acetic acid and / or salts thereof. In another preferred embodiment of the present invention, the organic acid and / or its salt may be citric acid and / or its salt. In yet another preferred embodiment of the present invention, the organic acid and / or its salt may be malic acid and / or its salt.

[0016] <Acetic acid and / or its salts> The acetic acid and / or salt thereof used in the protein removal composition of the present invention can be those commonly used in the art. The acetic acid salt is not particularly limited as long as it is an acetate salt that is alkaline when prepared as an aqueous solution, and examples include sodium acetate, potassium acetate, lithium acetate, beryllium acetate, magnesium acetate, aluminum acetate, calcium acetate, rubidium acetate, strontium acetate, cesium acetate, barium acetate, and ammonium acetate.

[0017] <Citric acid and / or its salts> The citric acid and / or salt thereof used in the protein removal composition of the present invention can be those commonly used in the art. The salt of citric acid is not particularly limited as long as it is a citrate that is alkaline when prepared as an aqueous solution, and examples include monosodium citrate, disodium citrate, trisodium citrate, monopotassium citrate, dipotassium citrate, tripotassium citrate, lithium citrate, beryllium citrate, magnesium citrate, aluminum citrate, calcium citrate, rubidium citrate, strontium citrate, cesium citrate, barium citrate, monoammonium citrate, diammonium citrate, and triammonium citrate.

[0018] <Malic acid and / or its salts> The malic acid and / or salt thereof used in the protein removal composition of the present invention can be those commonly used in the art. The malic acid salt is not particularly limited as long as it is an alkaline malate salt when prepared in aqueous solution, and examples include monosodium malate, disodium malate, monopotassium malate, dipotassium malate, lithium malate, beryllium malate, magnesium malate, aluminum malate, calcium malate, rubidium malate, strontium malate, cesium malate, barium malate, monoammonium malate, and diammonium malate.

[0019] The concentration of the organic acid and / or its salt in the protein removal composition of the present invention may be 0.1 to 70% by mass, preferably 0.5 to 60% by mass, more preferably 1 to 55% by mass, and even more preferably 5 to 50% by mass.

[0020] (2) Perorganic acids and / or salts thereof Examples of percarboxylic acids that can be used in the protein removal composition of the present invention include, but are not limited to, peracetic acid and / or its salt, performic acid and / or its salt, perpropionic acid and / or its salt, perbutanoic acid and / or its salt, perpentanoic acid and / or its salt, perhexanoic acid and / or its salt, perheptanoic acid and / or its salt, peroctanoic acid and / or its salt, percitric acid and / or its salt, permalic acid and / or its salt, perlactic acid and / or its salt, persuccinic acid and / or its salt, perglutaric acid and / or its salt, and perglutaric acid and / or its salt. Perorganic acids commonly used in the art can be used as perorganic acids in the protein removal composition of the present invention. In one embodiment of the present invention, the perorganic acid and / or its salt may be peracetic acid and / or its salt. <Peracetic acid> As the protein removal composition of the present invention and / or salt thereof, those commonly used in the art may be used.

[0021] The concentration of perorganic acid and / or its salt in the protein removal composition of the present invention may be 0.001 to 15% by mass. In one embodiment of the present invention, the concentration of peracetic acid in the protein removal composition may be, for example, 0.001% by mass, 0.005% by mass, 0.01% by mass, 0.1% by mass, 0.3% by mass, 0.4% by mass, 0.5% by mass, 0.6% by mass, 1.0% by mass, 3.0% by mass, 4.0% by mass, 5.0% by mass, 10% by mass, or 15% by mass, but is not limited to these. In one embodiment of the present invention, the concentration of peracetic acid in the protein removal composition is, for example, 0.001 to 15% by mass, 0.001 to 10% by mass, 0.001 to 5% by mass, 0.001 to 3% by mass, 0.005 to 15% by mass, 0.005 to 10% by mass, 0.005 to 5% by mass, 0.005 to 3% by mass, 0.01 to 15% by mass, 0.01 to 10% by mass, 0.01 to 5% by mass, 0.01 to 3% by mass, 0.1 to 15% by mass, 0.1 to 10% by mass, 0.1 to 5% by mass, 0 The concentration may be 0.1-3% by mass, 0.3-15% by mass, 0.3-10% by mass, 0.3-5% by mass, 0.3-3% by mass, 0.4-15% by mass, 0.4-10% by mass, 0.4-5% by mass, 0.4-3% by mass, 0.5-15% by mass, 0.5-10% by mass, 0.5-5% by mass, 0.5-3% by mass, 0.6-15% by mass, 0.6-10% by mass, 0.6-5% by mass, 0.6-3% by mass, 1.0-15% by mass, 1.0-10% by mass, 1.0-5% by mass, 1.0-3% by mass, etc. In one embodiment of the present invention, the concentration of perorganic acid and / or its salt in the protein removal composition is preferably 0.001-10% by mass, more preferably 0.005-5% by mass, and even more preferably 0.01-3% by mass.

[0022] (3) Hydrogen peroxide The protein removal composition of the present invention may further contain hydrogen peroxide as an optional component. In the protein removal composition of the present invention, hydrogen peroxide itself has bactericidal and cleaning properties, and therefore not only contributes to enhancing the bactericidal and cleaning effect of the entire composition, but also contributes to the generation and maintenance (stability in aqueous solution) of a sufficient amount of peracetic acid through an equilibrium reaction with acetic acid. Therefore, the bactericidal and cleaning effect of the composition of the present invention can be further enhanced by combining acetic acid and hydrogen peroxide.

[0023] The concentration of hydrogen peroxide in the protein removal composition of the present invention may be 0.001 to 25% by mass, preferably 0.005 to 20% by mass, more preferably 0.01 to 15% by mass, and even more preferably 0.02 to 10% by mass. If the concentration of hydrogen peroxide is too low, the amount of peracetic acid produced by the equilibrium reaction with acetic acid may not be sufficient, and the sterilization and cleaning effect of the present invention may not be fully exhibited. On the other hand, if the concentration of hydrogen peroxide is too high, the above effect will not be enhanced, and a safety problem may arise.

[0024] (4) Persulfuric acid and / or salts thereof The protein removal composition of the present invention may optionally contain persulfuric acid and / or its salts. By further containing persulfuric acid and / or its salts, the protein removal composition of the present invention has good protein removal ability while meeting wastewater discharge standards.

[0025] The persulfate and / or salt thereof that can be used in the protein removal composition of the present invention are not particularly limited as long as they provide good protein removal power while meeting wastewater discharge standards, but examples include ammonium persulfate, sodium persulfate, potassium persulfate, oxone (2KHSO5·KHSO4·K2SO4), potassium hydrogen persulfate, and persulfate. In one embodiment of the present invention, the persulfate and / or salt thereof may be ammonium persulfate. In one embodiment of the present invention, the persulfate and / or salt thereof may be sodium persulfate. In one embodiment of the present invention, the persulfate and / or salt thereof may be potassium persulfate. In one embodiment of the present invention, the persulfate and / or salt thereof may be oxone.

[0026] The concentration of persulfate and / or its salt in the protein removal composition of the present invention may be 0.01 to 60% by mass. In one embodiment of the present invention, the concentration of persulfate and / or its salt in the protein removal composition may be, for example, 0.01% by mass, 0.02% by mass, 0.03% by mass, 0.04% by mass, 0.05% by mass, 0.1% by mass, 0.2% by mass, 0.3% by mass, 0.4% by mass, 0.5% by mass, 0.6% by mass, 1.0% by mass, 2.0% by mass, 3.0% by mass, 4.0% by mass, 5.0% by mass, 10% by mass, 11% by mass, 12% by mass, 13% by mass, 14% by mass, 15% by mass, 20% by mass, 25% by mass, 30% by mass, 35% by mass, 40% by mass, 45% by mass, 50% by mass, 55% by mass, or 60% by mass, but is not limited to these values. In one embodiment of the present invention, the concentration of persulfuric acid and / or its salt in the protein removal composition may be, for example, 0.01 to 60% by mass, 0.03 to 50% by mass, 0.04 to 40% by mass, 0.05 to 30% by mass, 0.06 to 20% by mass, 0.07 to 10% by mass, and so on. In one embodiment of the present invention, the concentration of persulfuric acid and / or its salt in the protein removal composition may preferably be 0.08 to 7.5% by mass, more preferably 0.09 to 5% by mass, and even more preferably 0.1 to 2.5% by mass.

[0027] (5) Other ingredients The protein removal composition of the present invention may further contain, as needed, additives such as stabilizers, surfactants, thickeners, fragrances, colorants, hydrolytic enzymes, etc., which are commonly used in disinfectants and cleaning agents. In the protein removal composition of the present invention, the residue other than organic acids and / or their salts, perorganic acids and / or their salts, optional hydrogen peroxide, optional persulfuric acid and / or its salts, and additives added as needed is mainly water. Examples of stabilizers include, but are not limited to, phosphorus-based stabilizers, carboxylic acid-based stabilizers, and stanates.

[0028] The protein removal composition of the present invention can be used as is without dilution, or it can be diluted to any concentration to become a diluted protein removal composition. Water is usually used as the diluent. Examples of water used as the diluent include pure water, ultrapure water, distilled water, purified water, water for injection, and tap water. The dilution ratio is not particularly limited, as long as it is a dilution ratio that allows the diluted protein removal composition to exhibit a bactericidal and cleaning effect at a concentration, but it is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0029] 2. Dilution composition for protein removal The protein removal dilution composition of the present invention comprises one or more selected from the group consisting of organic acids and / or salts thereof, and perorganic acids and / or salts thereof, and further comprises additional water as a diluent. The details of each component are as described above.

[0030] The protein removal dilution composition of the present invention can be prepared by diluting the above-mentioned protein removal composition with water. As described above, the dilution ratio is not particularly limited, as long as it is a dilution ratio that can produce a concentration that exhibits a protein removal effect as a protein removal dilution composition, but is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0031] In one embodiment of the present invention, the protein removal dilution composition may have a concentration of perorganic acid and / or its salt of 0.0001 to 0.1% by mass, preferably 0.001 to 0.05% by mass, more preferably 0.002 to 0.04% by mass, even more preferably 0.003 to 0.03% by mass, and so on.

[0032] In one embodiment of the present invention, the protein removal dilution composition may have a concentration of organic acid and / or its salt of 0.01 to 10% by mass, preferably 0.05 to 6% by mass, more preferably 0.1 to 5.5% by mass, and even more preferably 0.2 to 5% by mass.

[0033] In one embodiment of the present invention, if the protein removal dilution composition contains persulfuric acid and / or a salt thereof, the concentration of persulfuric acid and / or a salt thereof may be 0.001 to 1% by mass, preferably 0.003 to 0.8% by mass, more preferably 0.004 to 0.6% by mass, and even more preferably 0.005 to 0.5% by mass.

[0034] In one embodiment of the present invention, the protein removal dilution composition contains 0.01 to 10% by mass of an organic acid and / or its salt, The pH value of the aforementioned composition may be between 4.0 and 10.0.

[0035] In one embodiment of the present invention, the protein removal dilution composition contains 0.0001 to 0.1% by mass of perorganic acid and / or its salt, The pH value of the aforementioned composition may be between 4.0 and 10.0.

[0036] In one embodiment of the present invention, the protein removal dilution composition contains 0.01 to 10% by mass of an organic acid and / or its salt, and 0.0001 to 0.1% by mass of a perorganic acid and / or its salt. The pH value of the aforementioned composition may be between 4.0 and 10.0.

[0037] In one embodiment of the present invention, the protein removal dilution composition contains 0.01 to 10% by mass of an organic acid and / or its salt, and 0.001 to 1% by mass of persulfuric acid and / or its salt. The pH value of the aforementioned composition may be between 4.0 and 10.0.

[0038] In one embodiment of the present invention, the protein removal dilution composition contains 0.0001 to 0.1% by mass of perorganic acid and / or its salt, and 0.001 to 1% by mass of persulfuric acid and / or its salt. The pH value of the aforementioned composition may be between 4.0 and 10.0.

[0039] In one embodiment of the present invention, the protein removal dilution composition contains 0.01 to 10% by mass of an organic acid and / or its salt, 0.0001 to 0.1% by mass of a perorganic acid and / or its salt, and 0.001 to 1% by mass of a persulfuric acid and / or its salt. The pH value of the aforementioned composition may be between 4.0 and 10.0.

[0040] 3. Method for producing protein removal composition and protein removal dilution composition In one embodiment of the present invention, a method for producing a protein removal composition comprises at least the following components: (i) One or more selected from the group consisting of organic acids and / or salts thereof, and perorganic acids and / or salts thereof, (ii) Hydrogen peroxide, which is an optional component, (iii) Persulfate and / or a salt thereof, which is an optional component The method may include a mixing step in which the components are mixed. This manufacturing method does not generate neutralization heat and has good workability. The components are as described above. The order in which the components are mixed is arbitrary, and in the protein removal composition of the present invention, the mixed components are in equilibrium.

[0041] The acetate salt mentioned above can be any acetate salt that is alkaline when prepared as an aqueous solution. For example, sodium acetate, potassium acetate, lithium acetate, beryllium acetate, magnesium acetate, aluminum acetate, calcium acetate, rubidium acetate, strontium acetate, cesium acetate, barium acetate, and ammonium acetate can be used, but are not limited to these. In one embodiment of the present invention, the acetate salt may be sodium acetate. In another embodiment of the present invention, the acetate salt may be potassium acetate.

[0042] In one embodiment of the present invention, a method for producing a protein removal composition comprises at least the following components: (i) One or more selected from the group consisting of organic acids and / or salts thereof, and perorganic acids and / or salts thereof, (ii) Hydrogen peroxide, which is an optional component, (iii) Persulfate and / or a salt thereof, which is an optional component (iii) Alkali and The method may include a mixing step of mixing the components. In this manufacturing method, neutralization heat is generated, increasing the parallel transfer velocity and accelerating the reaction. The components are as described above. The order in which the components are mixed is arbitrary, and in the protein removal composition of the present invention, the mixed components are in equilibrium.

[0043] Examples of alkalis that can be used include, but are not limited to, sodium hydroxide, potassium hydroxide, lithium hydroxide, beryllium hydroxide, magnesium hydroxide, aluminum hydroxide, calcium hydroxide, rubidium hydroxide, strontium hydroxide, cesium hydroxide, barium hydroxide, and ammonia. In one embodiment of the present invention, the alkali may be sodium hydroxide. In another embodiment of the present invention, the alkali may be potassium hydroxide.

[0044] The above manufacturing method using alkali may include a step of mixing one or more selected from the group consisting of organic acids and / or their salts, and perorganic acids and / or their salts, with alkali, and then optionally mixing in hydrogen peroxide solution at 30-50°C. In this manufacturing method, neutralization heat is generated, and by utilizing the neutralization heat generated by mixing one or more selected from the group consisting of organic acids and / or their salts, and perorganic acids and / or their salts, with alkali, hydrogen peroxide solution can be mixed in at 30-50°C, thereby increasing the parallel transfer rate and accelerating the reaction.

[0045] In one embodiment of the present invention, the method for producing a protein removal composition is the following steps (A) and (B): Step (A) A step of mixing at least one selected from the group consisting of (i) organic acids and / or salts thereof, and perorganic acids and / or salts thereof, (ii) hydrogen peroxide as an optional component, (iii) persulfuric acid and / or salts thereof as an optional component, and (iv) an alkali as an optional component; Step (B) A step in which the aqueous solution (a) obtained in step (A) is allowed to stand for one day or more. It may include the following. The aqueous solution (a) obtained in step (A) is allowed to stand in step (B) until it reaches equilibrium. In embodiments using acetate, the temperature at which it is allowed to stand in step (B) is preferably 20 to 60°C, but more preferably 20 to 50°C. The time at which it is allowed to stand in step (B) is preferably one day or more, and may be, for example, two days or more, three days or more, five days or more, ten days or more, thirty days or more, etc. In embodiments using alkali, as described above, the reaction can be accelerated by the generation of neutralization heat.

[0046] In yet another embodiment of the present invention, a method for producing a protein removal composition is the following steps (C) to (E): Step (C) A step of mixing at least one selected from the group consisting of (i) organic acids and / or salts thereof, and perorganic acids and / or salts thereof, (ii) hydrogen peroxide as an optional component, and (iii) persulfuric acid and / or salts thereof as an optional component; Step (D) is a step in which the aqueous solution (c) obtained in step (C) is left to stand for one day or more to obtain aqueous solution (d); Step (E) A step of mixing the aqueous solution (d) obtained in step (D), (iv) alkali, and water. It may include the following. The aqueous solution (c) obtained in step (C) is allowed to stand until it reaches equilibrium. The temperature at which it is allowed to stand in step (D) is preferably 20 to 60°C, but more preferably 20 to 50°C. The time at which it is allowed to stand in step (D) is preferably one day or more, and may be, for example, two days or more, three days or more, five days or more, ten days or more, thirty days or more, etc. After that, (iv) alkali and water are mixed into the aqueous solution (d) that has reached equilibrium.

[0047] In one embodiment of the present invention, a method for producing a protein removal dilution composition comprises at least the following components: (i) One or more selected from the group consisting of organic acids and / or salts thereof, and perorganic acids and / or salts thereof, (ii) Hydrogen peroxide, which is an optional component, (iii) Persulfate and / or a salt thereof, which is an optional component (iv) Arbitrarily with an alkali, A mixing process in which the following are mixed, Dilution step to dilute the resulting mixture It may include the following. Each component is as described above. In the method for producing the protein removal dilution composition of the present invention, the dilution step may include mixing the mixture obtained in the mixing step with water. Examples of water used as a diluent include pure water, ultrapure water, distilled water, purified water, water for injection, and tap water.

[0048] 5. Sterilization and cleaning method using a protein removal composition The protein removal composition or protein removal dilution composition of the present invention can be used as is without dilution, or diluted to any concentration, and used for purposes such as disinfecting and cleaning medical devices, water pipes, beverage and food containers, industrial wastewater, cooling water for air conditioning equipment, clothing, cooking utensils, tableware, bathrooms, kitchens, washing machines, bath boilers, furniture, and pets.

[0049] One embodiment of the present invention provides a method for sterilizing and cleaning medical instruments using the protein removal composition or the protein removal dilution composition. In the sterilization and cleaning method of the present invention, the method for sterilizing and cleaning the medical instruments may be any of the following: immersion, spraying, coating, liquid flow, circulation, or sealing. In the sterilization and cleaning method of the present invention, the amount of the protein removal composition or protein removal dilution composition used and the sterilization and cleaning time can be appropriately selected according to the type and amount of microorganisms, the concentration of the protein removal composition or protein removal dilution composition, etc.

[0050] In the sterilization and cleaning method of the present invention, the medical instruments include, but are not limited to, dialysis instruments, endoscopic instruments, surgical instruments, obstetric and urological instruments, anesthesia equipment, ventilators, dental instruments, and injection needles. In the sterilization and cleaning method of the present invention, the medical instruments are preferably dialysis instruments.

[0051] The protein removal composition and protein removal dilution composition of the present invention are suitable because they are less corrosive to objects to be sterilized and cleaned, such as medical instruments and water pipes, and therefore a rust-preventive effect can be expected. In addition to the protein removal effect and rust-preventive effect described above, the protein removal composition and protein removal dilution composition of the present invention can also be expected to have a sterilizing effect, a scale removal effect, and a biofilm removal effect, and furthermore, they have the advantage of being low-odor. [Examples]

[0052] Examples of the present invention are shown below. However, these examples are illustrative of the embodiments of the present invention and are not intended to limit the scope of the present invention.

[0053] <Method for Measuring Hydrogen Peroxide Concentration in Protein Removal Composition> In the present invention, the hydrogen peroxide concentration of the protein removal composition (peracetic acid composition) was determined by redox titration. Specifically, about 0.1 g of the sample was precisely weighed and placed in a 250 mL Erlenmeyer flask. 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid were added to prepare a test solution. A few drops of ferroin test solution were added to this test solution, and it was titrated with a 0.1 mol / L cerium(IV) sulfate solution to calculate the hydrogen peroxide concentration.

[0054] <Method for Measuring Acetic Acid and Peracetic Acid Concentrations in Protein Removal Composition> In the present invention, the acetic acid concentration and peracetic acid concentration of the protein removal composition were determined by neutral titration. Specifically, about 0.1 g of the sample of the protein removal composition was precisely weighed and placed in a 100 mL beaker. Approximately 50 mL of pure water was added to prepare a test solution. This test solution was titrated with a 0.1 mol / L sodium hydroxide solution, and the acetic acid concentration was calculated from the added amount at the first inflection point, and the peracetic acid concentration was calculated from the added amount from the first inflection point to the second inflection point.

[0055] <pH Measurement> The protein removal composition was appropriately diluted with pure water to prepare 50 g of a sample solution. The pH of each sample solution was measured using a pH meter (LAQUA, D-71S, manufactured by Horiba, Ltd.).

[0056] <Protein Removal Test> A protein removal composition was appropriately diluted with pure water to prepare 50 g of sample solution. A washing evaluation indicator (Nescos IC W·I, manufactured by Sakura Color Products Corporation) was immersed in each sample solution for 60 minutes, then washed with 10 mL of pure water and dried at room temperature. The color difference (ΔEab) from the clean white area of ​​the washing evaluation indicator was measured using a handheld spectrophotometer (NF555, manufactured by Nippon Denshoku Industries Ltd.) set to a 1C light source and a 2-degree field of view. The protein removal rate was calculated by setting the color difference of the unwashed washing evaluation indicator to 100 and using the ratio of the color difference after washing.

[0057] <Example 1> 39.9 g of pure water, 10.0 g of 80% by mass acetic acid (manufactured by Showa Denko K.K.), and 50.1 g of sodium acetate trihydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) were mixed in a PE container to obtain a protein removal composition containing 8.0% by mass acetic acid and 30.2% by mass sodium acetate, as described in Example 1 of Table 1.

[0058] <Example 2> In the same manner as in Example 1, 62.7 g of pure water, 8.8 g of citric acid monohydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.), and 28.5 g of trisodium citrate dihydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) were mixed in a PE container to obtain a protein removal composition containing 8.0% by mass of citric acid and 25.0% by mass of trisodium citrate, as described in Example 2 of Table 1.

[0059] <Example 3> 8.1 g of pure water, 0.02 g of 60% by mass 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, manufactured by Italmatch Japan Co., Ltd., product name: Dayquest 2010), 0.01 g of disodium ethylenediaminetetraacetate dihydrate (EDTA·2Na·2H2O, manufactured by MP Biomedicals, Inc.), 12.5 g of 80% by mass acetic acid (manufactured by Showa Denko K.K.), 17.4 g of 35% by mass hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Company, Inc., product name: Dia Power HP), and 62.0 g of sodium acetate trihydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) were mixed in a PE container. After mixing, the mixture was aged at 25°C for 7 days to obtain a protein removal composition containing 5.8% by mass of hydrogen peroxide, 8.6% by mass of acetic acid, 0.45% by mass of peracetic acid, 33.6% by mass of sodium acetate, 0.01% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 0.01% by mass of disodium ethylenediaminetetraacetate, as described in Example 4 of Table 1.

[0060] <Example 4> 23.0 g of pure water, 0.02 g of 60% by mass 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP, manufactured by Italmatch Japan Co., Ltd., product name: Dayquest 2010), 0.01 g of disodium ethylenediaminetetraacetate dihydrate (EDTA·2Na·2H2O, manufactured by MP Biomedicals, Inc.), 10.0 g of 80% by mass acetic acid (manufactured by Showa Denko K.K.), 17.4 g of 35% by mass hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Company, Inc., product name: Dia Power HP), and 49.6 g of sodium acetate trihydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) were mixed in a PE container. After mixing, the mixture was aged at 25°C for 7 days to obtain a protein removal composition containing 5.8% by mass of hydrogen peroxide, 7.6% by mass of acetic acid, 0.40% by mass of peracetic acid, 29.9% by mass of sodium acetate, 0.01% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid, and 0.01% by mass of disodium ethylenediaminetetraacetate, as described in Example 4 of Table 1.

[0061] <Example 5> In the same manner as in Example 1, 40.0 g of the protein removal composition described in Example 4 of Table 1 and 3.9 g of a 48% by mass sodium hydroxide solution (manufactured by Kanto Chemical Co., Ltd.) were mixed in a PE container to obtain the protein removal composition described in Example 5 of Table 1.

[0062] <Example 6> In the same manner as in Example 1, 40.0 g of the protein removal composition described in Example 4 of Table 1 and 4.3 g of a 48% by mass sodium hydroxide solution (manufactured by Kanto Chemical Co., Ltd.) were mixed in a PE container to obtain the protein removal composition described in Example 6 of Table 1.

[0063] <Example 7> In the same manner as in Example 1, 40.0 g of the protein removal composition described in Example 4 of Table 1 and 4.6 g of a 48% by mass sodium hydroxide solution (manufactured by Kanto Chemical Co., Ltd.) were mixed in a PE container to obtain the protein removal composition described in Example 7 of Table 1.

[0064] <Example 8> In the same manner as in Example 1, 62.5 g of pure water, 25.0 g of the protein removal composition described in Example 4 of Table 1, and 12.5 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 8 of Table 1.

[0065] <Example 9> In the same manner as in Example 1, 37.5 g of pure water, 50.0 g of the protein removal composition described in Example 4 of Table 1, and 12.5 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 9 of Table 1.

[0066] <Example 10> In the same manner as in Example 1, 47.5 g of pure water, 50.0 g of the protein removal composition described in Example 4 of Table 1, and 2.5 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 10 of Table 1.

[0067] <Example 11> In the same manner as in Example 1, 49.5 g of pure water, 50.0 g of the protein removal composition described in Example 4 of Table 1, and 0.5 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 11 of Table 1.

[0068] <Example 12> In the same manner as in Example 1, 49.7 g of pure water, 50.0 g of the protein removal composition described in Example 4 of Table 1, and 0.25 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 12 of Table 1.

[0069] <Example 13> In the same manner as in Example 1, 49.9 g of pure water, 50.0 g of the protein removal composition described in Example 4 of Table 1, and 0.13 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 13 of Table 1.

[0070] <Example 14> In the same manner as in Example 1, 50.0 g of pure water, 50.0 g of the protein removal composition described in Example 4 of Table 1, and 0.025 g of ammonium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 14 of Table 1.

[0071] <Example 15> In the same manner as in Example 1, 62.5 g of pure water, 25.0 g of the protein removal composition described in Example 4 of Table 1, and 12.5 g of sodium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 15 of Table 1.

[0072] <Example 16> In the same manner as in Example 1, 62.5 g of pure water, 25.0 g of the protein removal composition described in Example 4 of Table 1, and 12.5 g of potassium persulfate (manufactured by Mitsubishi Gas Chemical Company, Inc.) were mixed in a PE container to obtain the protein removal composition described in Example 16 of Table 1.

[0073] <Example 17> In the same manner as in Example 1, 62.5 g of pure water, 25.0 g of the protein removal composition described in Example 4 of Table 1, and 12.5 g of a persulfate compound (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., product name: Oxon) were mixed in a PE container to obtain the protein removal composition described in Example 17 of Table 1.

[0074] <Comparative Example 1> In the same manner as in Example 1, 62.5 g of pure water and 37.5 g of 80% by mass acetic acid (manufactured by Showa Denko K.K.) were mixed in a PE container to obtain the protein removal composition described in Comparative Example 1 of Table 1.

[0075] <Comparative Example 2> In the same manner as in Example 1, 67.2 g of pure water and 32.8 g of citric acid monohydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) were mixed in a PE container to obtain the protein removal composition described in Comparative Example 2 of Table 1.

[0076] <Comparative Example 3> In the same manner as in Example 1, 20.9 g of pure water, 0.2 g of pyrophosphate (manufactured by Junsei Chemical Co., Ltd., product name: Diphosphate), 46.5 g of 80% by mass acetic acid (manufactured by Showa Denko K.K.), and 32.4 g of 35% by mass hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Co., Ltd., product name: Dia Power HP) were mixed in a PE container. After mixing, the mixture was aged at 25°C for 7 days to obtain a protein removal composition containing 8.0% by mass of hydrogen peroxide, 32.5% by mass of acetic acid, 6.0% by mass of peracetic acid, and 0.2% by mass of pyrophosphate, as described in Comparative Example 3 of Table 1.

[0077] <Comparative Example 4> In the same manner as in Example 1, 69.0 g of pure water, 0.2 g of pyrophosphate (manufactured by Junsei Chemical Co., Ltd., product name: Diphosphate), 13.0 g of 80% by mass acetic acid (manufactured by Showa Denko K.K.), and 17.8 g of 35% by mass hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Co., Ltd., product name: Dia Power HP) were mixed in a PE container. After mixing, the mixture was aged at 25°C for 7 days to obtain a protein removal composition containing 5.9% by mass of hydrogen peroxide, 9.8% by mass of acetic acid, 0.72% by mass of peracetic acid, and 0.2% by mass of pyrophosphate, as described in Comparative Example 4 of Table 1.

[0078] <Examples 101-1 to 101-5> The protein removal composition obtained in Example 1 was diluted with pure water at the dilution ratios shown in Table 2, and pH measurement and protein removal tests were performed to calculate the pH and protein removal rate. The results are shown in Table 2.

[0079] <Examples 102-1 to 102-2, 103, 104-1 to 104-6, 105 to 117, Comparative Examples 101 to 104> Similar to Example 101-1, the solution was diluted using the dilution ratios listed in Table 2, pH measurement and protein removal tests were performed, and the pH and protein removal rate were calculated. The results are shown in Table 2.

[0080] [Table 1]

[0081] [Table 2]

[0082] As described above, the present invention has demonstrated that it is possible to provide a protein removal composition that ensures wastewater meets sewage discharge standards. Furthermore, the protein removal composition of the present invention is a groundbreaking composition that can improve protein removal power without reducing the scale removal effect inherent in organic acids and perorganic acids.

Claims

1. It contains organic acids and their salts, perorganic acids and / or their salts, persulfuric acid and / or its salts, and hydrogen peroxide. The pH value is 4.0 to 6.

0. The total amount of the aforementioned organic acids and their salts is 5 to 50% by mass. The total amount of the aforementioned perorganic acids and their salts is contained in an amount of 0.01 to 3% by mass. The total amount of the persulfate and its salts is contained in an amount of 0.01 to 20% by mass. A protein removal composition for medical devices, comprising the hydrogen peroxide in an amount of 0.02 to 10% by mass.

2. The protein removal composition according to claim 1, wherein the pH value is 5 or higher.

3. The protein removal composition according to claim 1 or 2, wherein the organic acid is selected from acetic acid, citric acid, and malic acid.

4. The protein removal composition according to any one of claims 1 to 3, wherein the perorganic acid is peracetic acid.

5. The persulfate is ammonium persulfate, sodium persulfate, potassium persulfate, and oxone (2KHSO4). ５ ・KHSO ４ ・K ２ SO ４ A protein removal composition according to any one of claims 1 to 4, selected from ).

6. A protein removal dilution composition comprising the protein removal composition according to any one of claims 1 to 5 and water.

7. The protein removal dilution composition according to claim 6, wherein the total amount of the organic acid and its salt is 0.01 to 10% by mass.

8. The protein removal dilution composition according to claim 6 or 7, wherein the total amount of the perorganic acid and its salts is 0.0001 to 0.1% by mass.

9. The protein removal dilution composition according to any one of claims 6 to 8, wherein the total amount of the persulfate and its salts is contained in an amount of 0.001 to 1% by mass.

10. A method for producing a protein removal composition, The protein removal composition comprises organic acids and their salts, perorganic acids and / or their salts, and persulfuric acid and / or its salts. The pH value is between 4.0 and 10.

0. The aforementioned manufacturing method is Step (C) A step of mixing at least (i) an organic acid and its salt, and perorganic acid and / or its salt, (ii) hydrogen peroxide as an optional component, and (iii) persulfuric acid and / or its salt; Step (D): A step in which the aqueous solution (c) obtained in step (C) is left to stand for one day or more to obtain aqueous solution (d); A method for producing a protein removal composition, comprising the steps of: (E) mixing the aqueous solution (d) obtained in step (D), (iv) alkali, and water.

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