Mixing vial

Abstract

To provide medical and dental vials for storage, mixing and delivery of drugs such as buffered anesthetic solutions.SOLUTION: A mixing vial 10 includes: a hollow interior chamber 14; a neck part 16 having a distal open end 18 and a proximal open end 20; and a stopper 22 positioned in a sealing relationship, the stopper 22 having a hollow interior chamber with an open end 28 and a dislodgeable plug 30 positioned in and sealing the open end.SELECTED DRAWING: Figure 3

Description

Technical Field

[0001] This application relates to chemical vials. More specifically, this application relates to medical and dental vials for the storage, mixing, and delivery of drugs such as buffered anesthetic solutions.

Background Art

[0002] For various reasons, some drugs are stored and transported in two parts and then must be mixed immediately before administration. For example, powdered steroids may be mixed with various excipients immediately before injection, and local anesthetics may be mixed with a NaHCO3 buffer solution immediately before injection. In addition, some drugs require agitation immediately before injection and therefore require a headspace for effective agitation. At the same time, however, the gas in the headspace is susceptible to oxidative degradation during storage. These drugs benefit from vials that eliminate the headspace during storage but provide a headspace for agitation immediately before injection.

[0003]

[0004] Local anesthetic solutions exert their effect by blocking the transmission of nerve signals in the area of the nerve where the solution has accumulated. Generally, anesthetic solutions must be acidified to an acidic pH of about 4.0 (similar to vinegar) in order to obtain an appropriate shelf life. This acidic solution is painful to the patient when injected, which is yet another reason why people dislike having injections in a dental office or clinic. In addition, since the drug does not exert any effect at this low "storage" pH, the patient's body slowly adjusts to it after injection until numbness begins. <00000合である。 ​​​​​​​​​​​​You must wait a few minutes for the pH to rise to the pH of body tissues (approximately 7.4).

[0005] The solid evidence is that the pH of the anesthetic is raised to near-neutral immediately before injection ("buffering"). This indicates that not only is the pain associated with the injection significantly reduced, but the latency of the anesthetic effect is also greatly reduced. Many inventors have made cushioning widely common in both dentistry and medicine over the decades. Attempts have been made to enact legislation, but currently, for many reasons, none of the methods are satisfactory. I haven't done that.

[0006] An 8.4% sodium bicarbonate (NaHCO3) aqueous solution is used to buffer anesthetics. It is the most common solution used. NaHCO3 solution and local anesthetic solution are typically used for anesthesia. The drug is mixed in a ratio of approximately 9 parts to 1 part of NaHCO3 solution.

[0007] When dermatologists, plastic surgeons, and other physicians buffer anesthetics, they first administer the anesthetic solution via Draw the solution from one vial into a syringe, and then draw the NaHCO3 solution from another vial. Add NaHCO3 solution to the syringe. After each patient, each of their respective... Unused anesthetics and NaHCO3 solutions in the container must be discarded along with the needles and syringes. This protocol typically wastes over 90% of NaHCO3, and Two vials are required. In addition, this mixed protocol is prone to human error. In short, inappropriate drug ratios, sterility violations, and the intent to transfer single-patient drug vials to other patients. This can lead to protocol violations, including graphic "reuse," resulting in harmful medical consequences. The method is also somewhat complicated, time-consuming, and uneconomical. However, the risks Furthermore, despite the time and financial costs, many physicians believe that if properly implemented, Buffering anesthetics makes a significant difference in patient comfort.

[0008] A system for a physician to aspirate and mix anesthetic drugs using only one vial. It would be preferable to aspirate from one vial instead of two vials, saving valuable time. This saves time, makes the process safer, and reduces the cost of additional vials and extra buffer solution. As a result, the use of cushioning becomes more widespread, increasing patient comfort.

[0009] In the oral environment, particular skill is required, and there is a possibility of administering multiple injections to the same patient. Dentists typically use reusable, handheld metal syringes to inject anesthetic solutions. This syringe has been developed and integrated into a single design and is used in dentistry and oral surgery. This accounts for almost all syringes in use. This syringe is attached to the syringe. A disposable hollow injection needle and a "cartridge" or "cartridge" containing an anesthetic solution that can be placed inside a syringe. It is used with a special glass drug vial called a "carple". When placed in the syringe, the cartridge is punctured by the rear end of the needle, so the solution enters the needle It can flow out through. The cartridge is pushed by a push rod on the syringe. It has a driven piston. Therefore, when the dentist pushes the push rod, the piston moves The solution is driven through the attached needle.

[0010] The cartridge has the shape of a long, slender barrel. Most glass drugs are contained in the cartridge. Pack-type elastomers that are fastened using a crimp metal cap, a method typical for vials. One end is sealed with a membrane. The marked and important difference between a dental cartridge and a typical drug vial is size. The capacity of a dental cartridge is typically less than 2 ml, mainly due to the constraints imposed by the syringe fitting in the operator's hand and its use intraorally, whereas a typical drug vial has a capacity of 10 - 100 ml. And the important difference is size. The capacity of a dental cartridge is typically less than 2 ml, mainly due to the constraints imposed by the syringe fitting in the operator's hand and its use intraorally, whereas a typical drug vial has a capacity of 10 - 100 ml. One end is sealed with a membrane. The marked and important difference between a dental cartridge and a typical drug vial is size. The capacity of a dental cartridge is typically less than 2 ml, mainly due to the constraints imposed by the syringe fitting in the operator's hand and its use intraorally, whereas a typical drug vial has a capacity of 10 - 100 ml. One end is sealed with a membrane. The marked and important difference between a dental cartridge and a typical drug vial is size. The capacity of a dental cartridge is typically less than 2 ml, mainly due to the constraints imposed by the syringe fitting in the operator's hand and its use intraorally, whereas a typical drug vial has a capacity of 10 - 100 ml.

[0011] A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols. A dentist who buffers an anesthetic usually uses one of two commercially available systems. Both of these systems add significant time and cost to the procedure. The per - injection product cost of the currently commercially available systems is several times that of the non - buffered protocol. In one system for dental use, the dentist is required to use a syringe / needle combination that is quite different from the widely - used standard system in the industry. This system also requires a countertop device to hold both the anesthetic solution and the NaHCO3 solution in separate vials and load them into a disposable syringe / needle combination. This is time - consuming, costly, and its use is prone to violate the operator's ergonomics as well as aseptic and pharmacological protocols.

[0012] In another system for dental use, an injector is used to introduce NaHCO3 into a standard dental cartridge. This system requires separately loading NaHCO3 into each cartridge, which is time - consuming and, in some states, is legally prohibited except by a licensed pharmacist. In addition, this system causes a significant loss of the available drug amount in the cartridge and is also prone to operator error as well as aseptic and pharmacological protocol violations. In another system for dental use, an injector is used to introduce NaHCO3 into a standard dental cartridge. This system requires separately loading NaHCO3 into each cartridge, which is time - consuming and, in some states, is legally prohibited except by a licensed pharmacist. In addition, this system causes a significant loss of the available drug amount in the cartridge and is also prone to operator error as well as aseptic and pharmacological protocol violations. In another system for dental use, an injector is used to introduce NaHCO3 into a standard dental cartridge. This system requires separately loading NaHCO3 into each cartridge, which is time - consuming and, in some states, is legally prohibited except by a licensed pharmacist. In addition, this system causes a significant loss of the available drug amount in the cartridge and is also prone to operator error as well as aseptic and pharmacological protocol violations. In another system for dental use, an injector is used to introduce NaHCO3 into a standard dental cartridge. This system requires separately loading NaHCO3 into each cartridge, which is time - consuming and, in some states, is legally prohibited except by a licensed pharmacist. In addition, this system causes a significant loss of the available drug amount in the cartridge and is also prone to operator error as well as aseptic and pharmacological protocol violations. In another system for dental use, an injector is used to introduce NaHCO3 into a standard dental cartridge. This system requires separately loading NaHCO3 into each cartridge, which is time - consuming and, in some states, is legally prohibited except by a licensed pharmacist. In addition, this system causes a significant loss of the available drug amount in the cartridge and is also prone to operator error as well as aseptic and pharmacological protocol violations. This is likely to result in a violation of the rotocol rules.

[0013] Despite these drawbacks, both systems have found a limited market, and the buffer is dental This has proven to be highly desirable from the perspective of both medical and dental patients. The buffering process takes more time. To eliminate costs, make it cheaper, safer, and more similar to current surgical protocols. This will lead to wider use, benefiting both patients and dentists.

[0014] In the case of steroids, doctors usually use a special glass chamber divided into two chambers. A glass vial is provided. This glass vial has a plunger mechanism, which the physician pushes by hand. The contents of the chamber are mixed. "Act-O-Vial" is a special vial for these special vials. This is a typical example. Act-O-Vial consists of seven parts, and a specially shaped glass bar It requires an ial and equipment.

[0015] Act-O-Vial and similar specialty vials also have headspace for agitation. Used with drugs that benefit from having no headspace while storing what is needed. In this case, the fluid in the first chamber is stored without headspace, and then the second chamber... This allows for agitation by utilizing the headspace within the chamber.

[0016] In particular, mixing drugs in situ, including buffering local anesthetics and mixing steroids for injection. There is still a need to provide a quicker and cheaper method for mixing or stirring. Yes. Therefore, as follows, namely, the use of dental syringes that can be manufactured more easily. To provide a suitable mixed cartridge for use, each cartridge is blown individually around the mandrel. Instead of using complex shapes that would otherwise require cutting, extruded hollow glass tubes cut to a predetermined length are used. This requires fewer and simpler parts, thereby improving the filling and density of dental cartridges. To simplify the closing process, and to avoid contamination of the clean or sterile assembly lines required for the manufacture of dental cartridges. Eliminate the use of metal crimp caps for sealing, along with any metal debris and dust that may contaminate the drug. Provides the maximum internal volume for accommodating gas headspace and dental cartridges. Promotes the ability to eliminate the oxidative degradation associated with drugs, minimizing damage during drug storage. A minimal, simple component provides a mixed dental cartridge that gives the maximum internal volume for [purpose]. When mixing drugs, to provide a mixture or stirring of drugs used in medicine or dentistry. Reduces the possibility of operator error and violation of sterile or pharmacological protocols, making manufacturing difficult. Rather than requiring difficult, specially shaped vials or multi-part sealing mechanisms, typical medical Mixing vial stopper that can be used with vials and typical crimp-on caps. It provides time and cost savings, and facilitates the precise distribution of materials to be mixed for the operator. To avoid errors, to promote the use of buffered local anesthetics, in clinics and dental offices. To reduce the pain and waiting time associated with the administration of local anesthesia, various embodiments of the present invention are provided. It is desirable that this be done.

[0017] Other advantages of one or more embodiments are as per the following disclosures and claims, as interpreted in conjunction with the accompanying drawings. This will become clear from the scope. [Overview of the project] [Means for solving the problem]

[0018] The mixing vial has a vial stopper with an integrated, hollow chamber, and can be removed. A stopper can be used to separate the hollow stopper chamber from the vial chamber. Mixing of the contents of the vial chamber and the contents of the vial chamber, or in the resulting headspace It may be removed to allow stirring of the drug. [Brief explanation of the drawing]

[0019] [Figure 1] This is a side view of a conventional needle / syringe device used in conjunction with the vial of the present invention. [Figure 2] This is a perspective view of a conventional vial having a single chamber. [Figure 3] This is a disassembled and assembled vertical cross-sectional view of an embodiment of the mixing vial of the present invention, which has a removable stopper and needle (cutout) in a sealed position. [Figure 4] Figure 3 shows a vertical cross-sectional view of the embodiment, with the stopper and needle (shown in the cutaway) removed, the needle inserted into the vial to remove the stopper. [Figure 5] This is a side view of a conventional dental cartridge needle / syringe device used in conjunction with the cartridge of the present invention. [Figure 6] Figure 5 is a disassembled and assembled cross-sectional view of a conventional dental cartridge needle / syringe device. [Figure 7] This is a perspective view of a conventional dental cartridge having a single chamber. [Figure 8] This is a cross-sectional view of an embodiment of the mixing vial of the present invention in the form of a cartridge with a needle inserted inside, and the needle is shown as a cutout. [Figure 9] Figure 8 is a cross-sectional view of an embodiment in which the subcutaneous syringe plunger of the syringe is inserted through it into a piston having a hollow chamber, and the needle is inserted inside after the stopper has been removed, with the needle shown as a cutaway. [Figure 10]This is a cross-sectional view of an embodiment of the mixing vial of the present invention in the form of a cartridge with a needle inserted inside, the stopper being removed by the needle to perform mixing of the contents of two chambers. [Modes for carrying out the invention]

[0020] Referring to the drawings, Figure 1 shows a conventional prior art syringe / needle device, and Figure 2 The conventional prior art vial is shown below. The syringe / needle device in Figure 1 is disclosed below. Suitable for use in conjunction with embodiments of the mixing vial of the present invention, as described in more detail below. Conventional prior art vials do not have two chambers or stoppers, as described. It is indicated by purpose.

[0021] Figures 3 and 4 show the mixing vial of the present invention, indicated by reference numeral 10. Al10 is an economically feasible and time-saving drug that doctors administer before injection. It does not interfere with established surgical protocols and does not require new or unfamiliar surgical instruments. This method provides the ability to buffer local anesthetics.

[0022] Roughly speaking, the mixing vial 10 consists of a hollow internal chamber 14 and an open end at the tip 1 The container 12 is a substantially barrel-shaped container having a neck portion 16 having an 8 and a base end open end 20. An elastomer stopper 22 with a chamber is positioned inside the neck portion 16, and inside the neck portion 16 It is in a sealed relationship with the opposing side wall 24.

[0023] The stopper 22 having a chamber has a hollow internal chamber 26 and an open base end 28, A removable stopper 30 is placed inside the open end 28 to seal it. The annular edge 32 of 30 is an annular extension within the radially inward-extending stopper flange 36 of the stopper 22. It fits tightly into groove 34. The container 12 is made of glass, plastic, or a material suitable for the purposes of this invention. It may be made of any other material suitable for use. The stopper 22 is adjacent to the surface and Elastomer-based materials, including typical vial stopper materials for this use, that properly seal. It may be made of plastic or rubber material. The stopper 30 is PTFE, or the stopper 22 It is made of any material or combination of materials that is suitable for sealing and can withstand needle penetration. It may also be the case that the stopper 30 has an elastomer body and an edge to prevent needle penetration. Therefore, a PTFE receiving plate 31 is attached to the needle side.

[0024] The stopper 22 has a radially outward-extending annular flange 38 and is held in place by a metal clip 40. It is held in place on the neck portion 16. The metal clip 40 is held on the annular shoulder portion 42 on the neck portion 16. The neck portion 16 is secured with a clip, and the flange 38 is pressed against the side 45 of the tip of the neck portion 16.

[0025] As shown in Figures 3 and 4, the internal chamber 14 of the container 12 contains the solution 50, for example, local It contains an anesthetic solution or a physiological saline solution. The internal chamber 26 of the stopper 22 contains powder 5 2. It contains, for example, NaHCO3 or a powdered steroid preparation.

[0026] During operation, the mixing vial 10 of the present invention is used in the following manner. First, the present invention Prepare a mixing vial, and keep the two chambers separate to be mixed immediately before injection. The vial is filled with the appropriate drug or other substance to which it is desirable to combine. Inverting the syringe, the physician uses a typical disposable medical syringe 53 as shown in Figure 1. As shown in Figures 3 and 4, insert the syringe needle 55 into the stopper 22 which has a chamber. The doctor then inserts the syringe needle into the chamber 26 of the stopper 22 and the stopper 30 into the mixing chamber. It must be confirmed that Al 10 has been removed into chamber 14. The stopper 30 may float to the top of the solution being mixed, or it may remain in the solution and the drug It may be configured to help with mixing. Also, shake vial 10 to help with mixing. It may be done to provide a visual indication of mixing or premature seal failure by coloring or clouding. (Clouding) The reagent may be added to either chamber. The Alstopper assembly configuration eliminates the headspace gas in either one of the chambers. This allows the physician to dispense the pre-mixed drug solution from the inverted vial into a syringe. It is dispensed into the container and administered to the patient using a typical method.

[0027] Referring to Figures 5 and 6, the conventional dental cartridge 59 shown in Figure 7, etc. The conventional syringe 57 for use with vials configured as cartridges Conventional cartridge syringes also differ from the present invention, as further described below. It is useful for use with cartridge-type mixing vials.

[0028] As shown in Figures 8 and 9, the mixing vial 110 is in the form of a cartridge and is hollow. It has an internal chamber 114 and a neck portion 116, with a front end open end 118 and a base end open end 12 It has a roughly barrel-shaped container 112 having 0. The neck portion 116 is at the base end of the container 112 It is a part of the container 112, and is simply an extended part of the container tubular structure, and the wall thickness of the container 112 and The diameter is not reduced due to the neck portion 116. Elastomer, stopper with chamber The piston 122 is positioned inside the neck portion 116 and is in a sealed relationship with the inner opposing wall 124 of the neck portion 116. It is located there.

[0029] The stopper piston 122, which has a chamber, has a hollow internal chamber 126 and an open tip 12 A removable stopper 130 is located inside the open end 128 and has 8, and seals it. Therefore, the annular edge 132 of the plug 30 extends radially inward from the stopper 122. It fits tightly into the annular groove 134 in the flange 136. The container 112 is made of glass, plastic. It may be made of black, or any other material suitable for use in accordance with the purposes of the present invention. The topper piston 122 is made of elastomer plastic or that properly seals with the adjacent surface. The stopper piston 122 may be made of rubber material. The stopper 130 may be made of PTFE or rubber. Any material suitable for sealing and capable of withstanding penetration by the subcutaneous syringe plunger 146 It may be made of a combination of these. For example, the stopper 130 has an elastomer body and an edge It is also possible to attach a PTFE receiving plate 131 to the subcutaneous syringe side to prevent penetration of the subcutaneous syringe. It is attached. The stopper 130 may take the form of a sphere, a convex disc, or other form, and is mixed. It may be used for stirring chemical substances. The stopper piston 122 is sealed and safe For qualitative purposes, it may have annular ribs 138 or other auxiliary parts.

[0030] The open end 118 of the container 112 is held in place by a metal clip 140. It is sealed by a sealing cap 133.

[0031] When using, the medical mixing vial or cartridge 110 is placed inside the syringe 57. As a result, as shown in Figure 9, the cap 133 will be punctured by the needle 142. Then, move the push rod 146 downwards and first drill a hole in the stopper 122. Next, remove the stopper 130 as shown in Figure 9. Thus, the stopper 122 Mix the buffering agent and other chemical reagents 148 in chamber 126 with the solution 150 in chamber 114. This makes it possible to do so. Subsequently, the drug mixture manipulates the push rod 146 further downwards. The injection is administered to the patient by the action, and the shoulder portion 152 of the push rod 146 is a stopper 122 It is pressed against the stopper 122, slides down the container 112, and passes through the needle 142 to the container 11 Push downwards to act as a piston that hydraulically expels the liquid inside.

[0032] Another embodiment is shown in Figure 10. As shown in Figure 10, the mixing vial 210 is This is a typical syringe cartridge, comprising a hollow internal chamber 214 and an open end 2 at the tip. A substantially barrel-shaped container 21 has a neck portion 216 having 18 and a base end open end 220. It has 2. The neck portion 216 is a part of the container 212 that is at the tip of the container 212, and the container Since the wall thickness and diameter of 212 do not change due to the neck portion 216, it is simply an expansion of the container tubular structure. This is the part. An elastomer stopper 222 with a chamber is placed inside the neck part 216. The neck portion 216 is in a sealed relationship with the inner opposing wall 224. The stopper 222 extends radially outward. It has an annular flange 238 and ribs 239 and 241, and during storage and transport, container 21 It is held in place in the neck portion 216 by friction with 2. During use, the s The retention of the topper 222 is ensured by the proximal end-facing surface 260 of the syringe 57.

[0033] The stopper 222, which has a chamber, has a hollow internal chamber 226 and an open base end 228. A removable stopper 230 is placed inside the open end 228 to seal it. Therefore, the annular edge portion 232 of the plug 230 extends radially inward from the stopper flap 222. It fits tightly into the annular groove 234 inside flange 236. The base end side of stopper flange 236 is If the plug 230 gets caught on the base end side of the flange 236 after it has been removed from the groove 234 It may have radial grooves 237 for providing flow.

[0034] Container 212 is made of glass, plastic, or any other material suitable for use in accordance with the purposes of the present invention. It may be made of other materials. The stopper 222 is properly sealed with the adjacent surface. Typical vial stopper materials used include elastomer plastics or other materials. It may be made of a material. The stopper 230 is suitable for sealing with PTFE or stopper 222. Furthermore, it may be made of any material or combination of materials that can withstand the penetration of a needle. The stopper 230 may have an elastomer body and an edge, and to prevent the needle from penetrating, the needle side A PTFE receiving plate 233 is attached. The stopper 222 is an annular rib or other It may have an auxiliary part that can seal and hold. The neck portion 216 seals and holds the stopper 222 It may have inner opposing grooves, shelf-like sections, or flanges to assist in holding.

[0035] The open base end 220 of the container 212 is sealed by the piston 252. 52 is shown with a hollow recess 254 in the tip side, and the hollow recess 254 is a mixing vial An additional volume is added to the internal chamber 214 of 210, and the piston 252 is aligned towards the tip. This prevents damage to the base end of the needle 142 during advancement.

[0036] When using, the mixing vial or cartridge 210 is placed inside the syringe 144. As shown in Figure 10, the stopper 222 will be punctured by the needle 142. Subsequently, when the proximal end opposing syringe surface 260 comes into contact with the stopper tip side surface 240, the needle 142 This removes the plug 230 from the stopper 222, preventing hydraulic removal. Therefore, the stopper Chemical reagents 248 such as buffering material in chamber 226 of PA222 are local in chamber 214 It becomes possible to mix it with anesthetic solutions such as 250. The mixture is then dispensed using a syringe. The shrod 146 is operated toward the tip of the piston 252, and the liquid is passed through the needle 142. It is injected into the patient by being expelled under pressure.

[0037] Embodiments of the present invention have been disclosed, but the present invention is subject to modification and alteration, and the present invention is Those skilled in the art will understand that the patent is limited only to the claims below. For example, as an alternative to the disclosed embodiment, the vial may have two chambers instead of It may also have three or more chambers to allow for the mixing of more components. The chemical It may function to enhance the in-situ mixing of substances. The materials used may be solids, solid powders, fluids, gases, or mixtures of any or all of the above. It may be a substance. A coloring reagent, a turbidity reagent, or other reagent may be used to mix or char the components. Leakage in the seal between the plugs or to the outside may be visually indicated. The plug to be removed is It may be primarily rigid, having rigid or elastic parts, or primarily elastic, having rigid parts. The stopper is mainly elastic, or mainly rigid, having an elastic or rigid part. It is also acceptable. Any of the parts may improve, simplify, or improve the manufacturing of these parts. Features that shorten, improve, simplify, or shorten the overall assembly of the device. May include. Any part or the entire device may enhance the visual appeal of the device. It may include a mark. In this embodiment, the container or any part of the container is approximately circular in one plane. Although described as having a specific cross-sectional shape, it may have any other cross-sectional shape that makes it usable. You may do so.

Claims

1. A syringe cartridge container having a hollow internal chamber with a tubular portion having an open tip end and an open base end, A mixing vial comprising a stopper, which is sealed within the tubular portion and has a hollow internal chamber having an open end, a removable stopper positioned within the open end to seal the open end, the stopper of which may be removed by a syringe needle to allow mixing of the contents of the stopper chamber and the contents of the container chamber.

2. The vial according to claim 1, wherein the stopper is made entirely of an elastomer material.

3. The vial according to claim 1, wherein the container contains an anesthetic agent, and the internal chamber of the stopper contains a buffering reagent.

4. A mixing vial suitable for use in a cartridge syringe, A syringe cartridge container having a hollow internal chamber with a tubular portion having an open tip end and an open base end, A stopper is disposed in a sealed manner within the tip of the tubular portion, having a hollow internal chamber with an open base end, a removable plug disposed within the open end, and sealing the open end; A vial for mixing, including the contents.

5. The vial according to claim 4, wherein the piston having a hollow recess in the side surface of the tip seals the open end on the base side of the container.

6. The vial according to claim 4, wherein the inner diameter of the container that receives the stopper is uniform over the entire length of the container.

7. The vial according to claim 4, wherein the stopper is made of a homogeneous elastomer material.

8. The vial according to claim 7, wherein the stopper has an annular shelf-like portion having an inwardly facing annular groove for receiving the edge of the plug.

9. The vial according to claim 4, wherein the cartridge contains an anesthetic, and the internal chamber of the stopper contains a buffer solution.

10. The vial according to claim 4, wherein the stopper is rigid and comprises a perforated elastomer stopper that seals the front open end and an elastomer stopper having a rigid receiving plate that seals the base open end.

Images