Peripheral nerve stimulation for restless legs syndrome

Non-invasive peripheral nerve stimulation with personalized parameter adjustment using surface EMG sensing effectively treats RLS and PLMD by addressing variability in patient responses, achieving a 6.64-point reduction in RLS severity and improved response rates.

JP7864348B2Active Publication Date: 2026-05-25NOCTRIX HEALTH INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
NOCTRIX HEALTH INC
Filing Date
2020-10-02
Publication Date
2026-05-25

AI Technical Summary

Technical Problem

Existing electrical nerve stimulation therapies for conditions like Restless Legs Syndrome (RLS) and Periodic Leg Movement Disorder (PLMD) face variability in effectiveness due to individual patient responses, leading to challenges in establishing safe and reliable nerve activation, and current treatments often have significant side effects or require invasive medical devices.

Method used

A method involving non-invasive peripheral nerve stimulation (NPNS) using high-frequency pulsed electrical stimulation, coupled with surface EMG sensing to determine personalized stimulation parameters, including frequency and current levels, to effectively treat RLS and PLMD by identifying and adjusting to individual patient thresholds.

Benefits of technology

The method significantly reduces RLS symptoms by personalizing nerve stimulation, improving treatment efficacy and reducing side effects, as demonstrated by a 6.64-point reduction in RLS severity and increased response rate in clinical trials.

✦ Generated by Eureka AI based on patent content.

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Abstract

A system and method for treating patients with symptoms of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) using high-frequency stimulation by applying high-frequency pulsed electrical stimulation therapy signals to the peroneal nerve or its branches, where the therapy signals exceed the motor threshold of muscles stimulated by the peroneal nerve or its branches. Surface electromyography (sEMG) responses to the nerve stimulation can be used to assess patient responsiveness to the nerve stimulation or to assess nerve stimulation efficacy, for example, to compare various nerve stimulation parameter settings and select between such settings to address or balance one or more goals. The sEMG responses can be obtained with the muscle at rest or during muscle activation.
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