composition for inhibiting stain adhesion

Abstract

To provide an appropriate stain deposition inhibitory effect and a good use feeling, and reduce environmental impact.SOLUTION: A stain deposition inhibitory composition contains extract from at least one naturally derived component selected from Rosa canina fruit extract, Prunus mume fruit extract, Malva sylvestris extract, Ginkgo biloba extract, Centella asiatica extract, Uncaria gambir extract, and Paeonia lactiflora extract, as an active ingredient.SELECTED DRAWING: None

Description

[Technical Field]

[0001] This invention relates to a composition for inhibiting stain adhesion. [Background technology]

[0002] Tooth discoloration is known to be caused by the formation and adhesion of pigment deposits called stains to the teeth. Conventionally, stain-inhibiting compositions using vegetable oils, surfactants, polymer compounds, etc., have been proposed to suppress the adhesion of stains to teeth.

[0003] Patent Document 1 describes a stain adhesion inhibitor made from vegetable oil. Patent Document 2 describes a whitening gel containing a bleaching agent, an emulsifier, a gelling agent, a wetting agent, and a disinfectant consisting of a plant extract. The plant extract described is an extract of the plant Salvador persica.

[0004] Patent Document 3 describes a dental plaque and stain inhibitor containing plant-derived proteoglycans. [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Japanese Patent Publication No. 2019-112377 [Patent Document 2] Special Publication No. 2020-514247 [Patent Document 3] Japanese Patent Publication No. 2021-50147 [Overview of the Initiative] [Problems that the invention aims to solve]

[0006] Incidentally, stain-inhibiting compositions are required to provide a suitable stain-inhibiting effect and a good user experience, while also minimizing their impact on the environment.

Means for Solving the Problem

[0007] The composition for suppressing stain adhesion for solving the above problem has, as an active ingredient, an extract of at least one kind of natural-derived component selected from turnip extract, plum fruit extract, safflower extract, ginkgo extract, field bindweed extract, asiasarum extract, and peony extract.

[0008] In the above composition for suppressing stain adhesion, it is preferable that the extract of the natural-derived component is an extract extracted with 1,3-butylene glycol. In the above composition for suppressing stain adhesion, it is preferable that it does not substantially contain a bleaching agent.

Effect of the Invention

[0009] According to the composition for suppressing stain adhesion of the present invention, a preferable stain adhesion suppressing effect can be obtained, and since it is a water-soluble component, it is also easy to formulate into a preparation. In addition, a good feeling in use can be obtained. Furthermore, the impact on the environment can be reduced.

Mode for Carrying Out the Invention

[0010] Hereinafter, an embodiment in which the composition for suppressing stain adhesion according to the present invention (hereinafter, also simply referred to as "composition") is embodied will be described. The composition has, as an active ingredient, an extract of at least one kind of natural-derived component selected from turnip extract, plum fruit extract, safflower extract, ginkgo extract, field bindweed extract, asiasarum extract, and peony extract.

[0011] By using the extract of the above natural-derived component as an active ingredient, the adhesion of stains to teeth can be preferably suppressed. In addition, since the above natural-derived components are all water-soluble plant extracts, they are also easy to formulate into a preparation. In addition, a good feeling in use can be obtained. Furthermore, by using the extract of the above natural-derived component as an active ingredient, the impact on the environment can be reduced.

[0012] The extracts of natural origin components will be described below. <Extracts of Natural Origin Components> (Rose Extract) Rose extract is an extract obtained by extracting from the fruits of Rosa multiflora Thunb., which is a Rosaceae plant, using an extraction solvent. There are no particular restrictions on the rose extract, and commercially available rose extracts can be used.

[0013] (Plum Fruit Extract) Plum fruit extract is an extract obtained by extracting from the fruits of Prunus mume Sieb. et Zucc., which is a Rosaceae plant, using an extraction solvent. There are no particular restrictions on the plum fruit extract, and commercially available plum fruit extracts can be used.

[0014] (Malva Verticillata Extract) Malva verticillata extract is an extract obtained by extracting from the flowers of Malva verticillata L., which is a Malvaceae plant, using an extraction solvent. There are no particular restrictions on the malva verticillata extract, and commercially available malva verticillata extracts can be used.

[0015] (Ginkgo Extract) Ginkgo extract is an extract obtained by extracting from the leaves of Ginkgo biloba L., which is a Ginkgoaceae plant, using an extraction solvent. There are no particular restrictions on the ginkgo extract, and commercially available ginkgo extracts can be used.

[0016] (Bellflower Extract) Bellflower extract is an extract obtained by extracting from the leaves and stems of Campanula medium L., which is a Campanulaceae plant, using an extraction solvent. There are no particular restrictions on the bellflower extract, and commercially available bellflower extracts can be used.

[0017] (Rubia Cordifolia Extract) Rubia cordifolia extract is an extract obtained by extracting from the leaves and young branches of Morinda citrifolia L., which is a Rubiaceae plant, using an extraction solvent. There are no particular restrictions on the rubia cordifolia extract, and commercially available rubia cordifolia extracts can be used.

[0018] (Paeonia Lactiflora Extract) Peony extract is an extract obtained by extracting the roots of the peony plant, which belongs to the Paeoniaceae family, using an extraction solvent. There are no particular restrictions on the type of peony extract used, and commercially available peony extract can be used.

[0019] The extracts of the above-mentioned naturally derived ingredients may be used individually or in combination of two or more. <Extraction solvent> The extraction solvent used for extracting extracts of naturally derived ingredients is not particularly limited, but it is preferably a water-soluble solvent. A water-soluble solvent means water or an organic solvent that is miscible with water.

[0020] Specific examples of water-soluble solvents include, for example, water, methanol, ethanol, propanol, butanol, propanol, isopropanol, propylene glycol, 1,3-butylene glycol, isoprene glycol, ethylene glycol, diethylene glycol, acetone, and the like.

[0021] The type of water is not particularly limited and can include, for example, distilled water, pure water, ultrapure water, purified water, and tap water. The above water-soluble solvents may be used individually or in combination of two or more. Among these, using 1,3-butylene glycol makes it possible to reduce the amount of alcohol used, such as ethanol. Therefore, the appeal of being alcohol-free can be enhanced.

[0022] The following describes the method for extracting extracts from naturally derived ingredients. <Method for extracting naturally derived ingredient extracts> The method for extracting extracts from naturally derived ingredients is not particularly limited, and known extraction methods can be employed. For example, the naturally derived ingredients may be subjected to predetermined processing before being extracted using the extraction solvent. Specific examples of predetermined processing include, for example, grinding, cutting, roasting, and drying. When extracting with the extraction solvent, the extraction solvent may be heated as appropriate.

[0023] The heating temperature of the extraction solvent is not particularly limited, but is preferably 0°C or higher, more preferably 30°C or higher. It is also preferably 100°C or lower, and more preferably 80°C or lower.

[0024] The extraction time is not particularly limited, but is preferably 10 minutes or more, and more preferably 30 minutes or more. It is also preferably within 24 hours, and more preferably within 5 hours.

[0025] After extraction with an extraction solvent, the extracted extract may be separated as appropriate. The method of separating the extracted extract is not particularly limited and can be performed by means of filtration, centrifugation, etc. The extracted extract may be used as is or concentrated. After concentration, the extract may be freeze-dried, spray-dried, granulated, or dried to produce a powder. The extract powder may be granulated to produce granules or fine granules.

[0026] <Content in the treatment agent> The content of the extract of naturally derived ingredients relative to the total mass of the treatment agent is not particularly limited. The content of the extract of naturally derived ingredients is preferably 0.1% by mass or more, more preferably 0.5% by mass or more. It is also preferably 10% by mass or less, and more preferably 5% by mass or less.

[0027] As described later, when the extract of naturally derived ingredients is in powder form, it is preferable to ensure that the content ratio of the extract of naturally derived ingredients falls within the above numerical range when dissolving it in a solvent such as water for use.

[0028] The content of the extraction solvent relative to the total mass of the processing agent is not particularly limited. The content of the extraction solvent is preferably 90% by mass or more, more preferably 95% by mass or more. It is also preferably 99.9% by mass or less, and more preferably 99.5% by mass or less.

[0029] When 1,3-butylene glycol is used as the extraction solvent, the content of 1,3-butylene glycol relative to the total mass of the treatment agent is not particularly limited. The 1,3-butylene glycol content is preferably 30% by mass or more, more preferably 35% by mass or more, and even more preferably 40% by mass or more. Furthermore, it is preferably 70% by mass or less, more preferably 65% ​​by mass or less, and even more preferably 60% by mass or less.

[0030] <Other ingredients> Depending on the intended use, form, and application, the composition may also contain other components besides those mentioned above, such as disinfectants, antibacterial agents, surfactants, thickeners, stabilizers, preservatives, sweeteners, pH adjusters, antioxidants, fragrances, colorants, etc. Known components that can be incorporated into compositions may be used for each of these components. These components may be used individually or in combination of two or more.

[0031] However, in order to reduce the environmental impact, it is preferable that the content of artificially synthesized components, so-called synthetic components, in the other components is small. It is even preferable that synthetic components are substantially absent. Substantially absent means that their presence at an impurity level is acceptable.

[0032] The synthetic components should include, for example, high-molecular-weight compounds. Furthermore, it is preferable that surfactants and bleaching agents are not included. Specific examples of bleaching agents include, for example, sodium bicarbonate and potassium bicarbonate.

[0033] Furthermore, in order to improve the user experience, it is preferable that the content of vegetable oils in the other ingredients be small. It is even preferable that the product contains virtually no vegetable oils. The following are specific examples of other ingredients.

[0034] Specific examples of fungicides include cetylpyridinium chloride hydrate and hinokitiol. Specific examples of antibacterial agents include parabens, sodium benzoate, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, minocycline hydrochloride, isopropylmethylphenol, benzalkonium chloride, and benzethonium chloride.

[0035] Specific examples of surfactants include nonionic surfactants, anionic surfactants, and amphoteric surfactants. (Nonionic surfactant) Specific examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters such as sorbitan stearate and sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan laurate (also called polysorbate 20), polyoxyethylene sorbitan stearate (also called polysorbate 60), and polyoxyethylene sorbitan oleate (also called polysorbate 80), fatty acid alkanolamides such as lauric acid diethanolamide, and polyoxyethylene Examples include polyoxyethylene alkyl ethers such as lencheryl ether and polyoxyethylene oleyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, alkyl glycosides such as lauryl glycoside and decyl glycoside, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil (with an average number of added moles of ethylene oxide of 10, 20, 40, and 60), glycerin fatty acid esters, and polyoxyethylene propylene block copolymers.

[0036] (Anionic surfactant) Specific examples of anionic surfactants include sulfate ester salts such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate, sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate, acyl amino acid salts such as sodium cocoyl sarcosinate and sodium lauroyl methylalanine, and sodium cocoyl methyl taurate.

[0037] (Amphoteric surfactant) Specific examples of amphoteric surfactants include amino acid-type amphoteric surfactants such as N-lauryldiaminoethylglycine and N-myristyldiethylglycine, and betaine-based amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, N-alkyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine salt, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

[0038] Specific examples of thickening agents include sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, sodium alginate, xanthan gum, hydroxyethylcellulose, crystalline cellulose, hydroxypropyl methylcellulose, methylcellulose, and propylene glycol alginate. Thickening agents are also called binders.

[0039] Specific examples of stabilizers include sodium edetate, sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, and magnesium sulfate.

[0040] Specific examples of preservatives include, for example, 1,2-dibromo-2,4-dicyabutane, photosensitizers, isothiazolone derivatives, hydantoin derivatives, parabens, sodium benzoate, and phenol.

[0041] Specific examples of sweeteners include saccharin, sodium saccharin, acesulfame potassium, stevia extract, palatinose, palatinose, erythritol, maltitol, xylitol, and lactitol.

[0042] Specific examples of pH adjusters include, for example, citric acid, phosphoric acid, malic acid, pyrophosphate, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, etc.

[0043] Specific examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters. The fragrance may be natural or synthetic. It may also be a single fragrance or a blended fragrance.

[0044] Specific examples of fragrances include l-menthol, d-carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, fennel oil, cinnamon oil, cinnamaldehyde, peppermint oil, vanillin, and others.

[0045] Specific examples of colorants include legally approved pigments such as Green No. 1, Green No. 3, Blue No. 1, Yellow No. 4, Yellow No. 5, Red No. 102, and Red No. 3, as well as sodium copper chlorophyll and titanium dioxide.

[0046] <Application form, dosage form, and use of the composition> The application form of the composition is not particularly limited, and it can be used, for example, as a pharmaceutical product, a designated quasi-drug, or a cosmetic product.

[0047] The dosage form of the composition is not particularly limited and can be prepared as appropriate in solid, semi-solid, or liquid form. Examples of solid or semi-solid forms include powder, paste, or liquid, which are in accordance with the dosage forms of toothpaste specified by the Japan Toothpaste Manufacturers Association.

[0048] The use of the composition is not particularly limited, and known uses can be adopted as appropriate. Examples of uses for the composition include toothpaste, toothpaste powder, liquid toothpaste, moisturizing toothpaste, mouthwash, etc.

[0049] <Mechanism and Effects> The function and effects of the composition of this embodiment will now be described. (1) The composition contains as an active ingredient an extract of at least one naturally derived ingredient selected from rosehip extract, plum fruit extract, mallow extract, ginkgo extract, centella asiatica extract, catechu extract, and peony extract.

[0050] By using extracts of the above-mentioned naturally derived ingredients as active ingredients, the adhesion of stains to teeth can be effectively suppressed. Furthermore, since all of the above-mentioned naturally derived ingredients are water-soluble plant extracts, they can be easily incorporated into formulations. In addition, a pleasant user experience can be obtained. Moreover, by using extracts of the above-mentioned naturally derived ingredients as active ingredients, the environmental impact can be reduced.

[0051] (2) The extract of the naturally derived ingredient is an extract obtained with 1,3-butylene glycol. Therefore, it is possible to reduce the amount of alcohol used, such as ethanol. As a result, the appeal of being alcohol-free can be enhanced.

[0052] (3) The treatment agent contains virtually no bleaching agent. Therefore, the environmental impact can be further reduced. [Examples]

[0053] The following are examples to illustrate the structure and effects of the present invention in more detail, but the present invention is not limited to these examples. The compositions of Examples 1-7 and Comparative Examples 1-3 shown in Table 1 were prepared by extracting extracts of each naturally derived component according to conventional methods. A mixed solvent of purified water and 1,3-butylene glycol was used as the extraction solvent. In Table 1, the numbers to the right of each component represent the content (mass %) of each component.

[0054] The type and amount of naturally derived extracts, and the type and amount of extraction solvent, should be listed in the "Naturally Derived Extracts" column and the "Extraction Solvent" column, respectively.

[0055] [Table 1] (Evaluation test) The compositions of Examples 1-7 and Comparative Examples 1-3 were evaluated for their stain-inhibiting effect and usability. The evaluation methods and results are shown below.

[0056] (Method for evaluating the stain adhesion inhibition effect) A known hydroxyapatite disc (hereinafter also referred to as HAP disc) was immersed in distilled water for 2 minutes, and then air-dried for 2 hours to obtain a pre-adhesion HAP disc. The pre-adhesion HAP disc was examined using a colorimeter (Konica Minolta Sensing CR-241) to determine the color difference (L * value, a * value, b * The value is measured, and each obtained measurement is L * 0, a * 0, b * I set it to 0.

[0057] Next, an adhesion treatment was performed to apply the stain to the HAP disc before adhesion. The adhesion treatment involved immersion in a 2% bovine serum albumin aqueous solution for 10 minutes, deionized water for 1 minute, a 0.2% chlorhexidine hydrochloride gluconate solution for 2 minutes, deionized water for 1 minute, a 0.5% sample solution for 2 minutes, deionized water for 1 minute, a 0.3% ammonium iron citrate aqueous solution for 2 minutes, deionized water for 1 minute, a black tea solution for 10 minutes, and deionized water for 1 minute. This treatment was repeated 10 times.

[0058] The HAP disk after the adhesion treatment was air-dried for 2 hours to obtain the HAP disk after adhesion. For the HAP disk after adhesion, the color difference (L * value, a * value, b * value) was measured using the above color difference meter, and each obtained measurement value was designated as L * 1, a * 1, b * 1.

[0059] ΔE s was determined using the following formula (1). ΔE s = ((L * 1 - L * 0) 2 - (a * 1 - a * 0) 2 - (b * 1 - b * 0) 2 ) 1 / 2 ···(1) Also, as a comparative test, adhesion treatment was performed in the same manner as above using distilled water instead of the sample solution. For the HAP disk after adhesion, the color difference (L * value, a * value, b * value) was measured using the above color difference meter, and ΔE w was determined in the same manner as formula (1) in the comparative test.

[0060] Using ΔE s measured using each sample solution and ΔE w measured in the comparative test, the stain adhesion inhibition rate was determined from the following formula (2). Stain adhesion inhibition rate (%) = (1 - ΔE s / ΔE w ) × 100···(2) The stain adhesion inhibition effect was evaluated according to the following evaluation criteria. The results are shown in Table 1.

[0061] Furthermore, a higher stain adhesion inhibition rate indicates that stains are less likely to adhere, thus making a stain adhesion inhibition effect desirable. • Evaluation criteria for stain adhesion inhibition effect ◎ (Excellent): Stain adhesion inhibition rate is 30% or higher. ○○ (Good): Stain adhesion inhibition rate is 20% or more but less than 30% ○ (Acceptable): Stain adhesion inhibition rate is 10% or more but less than 20% × (Not acceptable): Stain adhesion inhibition rate is less than 10% (Method for evaluating user experience) The user experience was evaluated by sensory evaluation conducted by four monitors. First, 10 mL of the treatment agent for each example and comparative example was placed in the mouth and rinsed for 1 minute. The user experience at that time was evaluated on a 3-point scale according to the following evaluation criteria. The average of the evaluation values ​​of the four people was calculated, and the results are shown in Table 1.

[0062] • Evaluation criteria for user experience 3 points: It has no irritation or stickiness in the mouth and feels natural to use. Points 2: There is a slight irritation or sticky feeling in the mouth, but it is not a problem for use.

[0063] 1 point: The product causes a strong irritation or sticky feeling in the mouth, resulting in an unpleasant user experience. • Evaluation criteria for average score ○○ (Good): 2.5 points or more ○ (Acceptable): 2 points or more, less than 2.5 points × (Not acceptable): Less than 2 points (Evaluation results) Table 1 shows that Comparative Examples 1-3 all had a stain adhesion inhibition rate of less than 10%, indicating a small stain adhesion inhibition effect.

[0064] In contrast, all of Examples 1 to 7 showed a stain adhesion inhibition rate of 10% or more, confirming that a suitable stain adhesion inhibition effect can be obtained. Furthermore, because it is a water-soluble component, it was easy to incorporate into formulations. In addition, it was confirmed that it had a good feel when used. Moreover, because it uses extracts of naturally derived components as active ingredients, it can reduce the environmental impact compared to synthetic components.

Claims

1. A stain-inhibiting composition characterized by containing an extract of at least one naturally derived ingredient selected from mallow extract and catechu extract as an active ingredient.

2. The stain adhesion inhibitory composition according to claim 1, wherein the extract of the naturally derived component is an extract obtained by extracting with 1,3-butylene glycol.

3. A stain-inhibiting composition according to claim 1 or 2, which does not contain a bleaching agent.

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