Stabilized IgG4 antibody and its use

Mutating residues 219, 220, and 228 in the hinge region of IgG4 antibodies stabilizes them against reduction, significantly reducing half-antibody formation and enhancing manufacturing stability.

JP7870729B2Active Publication Date: 2026-06-05MEDIMMUNE LLC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
MEDIMMUNE LLC
Filing Date
2021-03-29
Publication Date
2026-06-05

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Abstract

The present disclosure relates to an antibody of the IgG4 class comprising two heavy chains, each of which comprises a human IgG4 constant region comprising a mutation. The present disclosure further relates to a method of treating a disorder or condition using an IgG4 antibody comprising two heavy chains, each of which comprises a human IgG4 constant region comprising a mutation.
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