Carbonated aerosol topical skin preparation

Abstract

To provide a carbonated aerosol topical skin application comprising stably emulsified ceramide lipids and having excellent moisturizing and coating properties.SOLUTION: Provided is a carbonated aerosol topical skin application consisting of an aerosol stock solution comprising the following components (A) to (D) and a propellant comprising component (E). (A) Ceramide lipid. (B) An ionic surfactant. (C) A water-soluble polymer. (D) Water. (E) Carbon dioxide gas.SELECTED DRAWING: None

Description

[Technical Field]

[0001] This invention relates to a carbonated aerosol skin preparation. [Background technology]

[0002] The stratum corneum, the outermost layer of the skin, has the function of maintaining skin flexibility and a smooth appearance by suppressing the entry of external substances and the evaporation of moisture from within the skin, while also retaining moisture itself. In the spaces between the keratinocytes that make up the stratum corneum, lipids called intercellular lipids are present, filling the gaps between the keratinocytes.

[0003] Approximately 50% of the lipid composition of intercellular lipids in the stratum corneum is ceramide lipid, and it is known that a decrease in ceramide lipids can lead to undesirable skin conditions such as rough skin, dry skin, and aging skin. Therefore, it is believed that supplementing with ceramide lipids topically can improve the condition of the stratum corneum, which has lost its function.

[0004] However, ceramide lipids have high crystalline properties and high melting points, making them difficult to stabilize in formulations. Therefore, in order to stably incorporate ceramides into topical skin preparations, it has been proposed to combine them with specific surfactants or water-soluble polymers (see, for example, Patent Documents 1 and 2).

[0005] Carbon dioxide is known to promote blood circulation and have a warming effect, and aerosol-type cosmetics using carbon dioxide as a propellant are used. For example, Patent Document 3 discloses an aerosol cosmetic that uses carbon dioxide as a propellant and contains a solid lipid, a powder of a specific particle size, and a nonionic surfactant, and has excellent skin penetration. [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] Japanese Patent Publication No. 2008-81407 [Patent Document 2] Japanese Patent Application Laid-Open No. 2012-214469 [Patent Document 3] Japanese Patent Application Laid-Open No. 2018-43932 [Summary of the Invention] [Problems to be Solved by the Invention]

[0007] Therefore, the present inventors examined an aerosol topical skin preparation containing ceramide lipid and using carbon dioxide gas as an aerosol agent. However, it was found that an emulsion containing ceramide lipid has a problem that the emulsion stability is impaired when carbon dioxide gas coexists, and particularly at high temperatures, the ceramide lipid is likely to precipitate, making it impossible to spray from the aerosol container.

[0008] Therefore, the present invention relates to a carbon dioxide aerosol topical skin preparation in which ceramide lipid is stably emulsified and which is excellent in moisture retention and spreadability. [Means for Solving the Problems]

[0009] The present inventors have found that by using carbon dioxide gas as an aerosol agent and combining ceramide lipid with an ionic surfactant and a water-soluble polymer, an aerosol topical skin preparation excellent in emulsion stability, moisture retention and spreadability can be obtained.

[0010] The present invention provides a carbon dioxide aerosol topical skin preparation comprising an aerosol stock solution containing the following components (A) to (D) and an aerosol agent containing a component (E). (A) Ceramide lipid (B) Ionic surfactant (C) Water-soluble polymer (D) Water (E) Carbon dioxide gas [Effects of the Invention]

[0011] The carbon dioxide aerosol topical skin preparation of the present invention has ceramide lipid stably emulsified and has excellent moisture retention and spreadability. [Modes for Carrying Out the Invention]

[0012] ●Aerosol stock solution The aerosol stock solution in the carbonated aerosol topical skin preparation of the present invention contains the following components (A) to (D).

[0013] 〔Component (A): Ceramide lipid〕 As the ceramide lipid of component (A), either natural ceramide or pseudo-ceramide may be used, and it preferably contains one or more selected from those represented by the following general formula (1) or (2).

[0014] Natural ceramide is represented by the general formula (1) and may be natural-derived ceramides or synthetic compounds having the same structure.

[0015]

Chemical formula

[0016] 〔In the formula, R 1 represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms which may be substituted with a hydroxyl group; Z 1 represents a methylene group or a methine group; X 1 , X 2 , and X 3 each independently represent a hydrogen atom, a hydroxyl group or an acetoxy group; X 4 represents a hydrogen atom or forms an oxo group together with an adjacent oxygen atom (however, when Z 1 is a methine group, either X 1 or X 2 is a hydrogen atom and the other does not exist. When X 4 forms an oxo group, X 3 does not exist.); R 2 represents a hydroxymethyl group or an acetoxymethyl group; R 3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 4represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms, which may be substituted with a hydroxyl group, or a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms, which may be substituted with a hydroxyl group, esterified to the ω-terminus of the alkyl group; the dashed line indicates that it may be an unsaturated bond.

[0017] In general formula (1), preferably, R 1 R is a linear alkyl group having 7 to 19 carbon atoms, more preferably 13 to 15 carbon atoms; 4 Examples include compounds in which a linear alkyl group having 9 to 27 carbon atoms may be substituted with a hydroxyl group, or a linear alkyl group having 9 to 27 carbon atoms to which linoleic acid is ester-bonded. Also, X 4 It is preferable that R represents a hydrogen atom or forms an oxo group with an oxygen atom. In particular, 4 Preferred members include tricosyl, 1-hydroxypentadecyl, 1-hydroxytricosyl, heptadecyl, 1-hydroxyundecyl, and nonacosyl groups in which linoleic acid is ester-bonded to the ω position.

[0018] The natural ceramide is preferably one or more selected from ceramides Type 1 to 7 (e.g., porcine and human ceramides described in Figure 2 of J. Lipid Res., 24:759 (1983) and Figure 4 of J. Lipid Res., 35:2069 (1994)) in which sphingosine, dihydrosphingosine, phytosphingosine, or sphingadienine are amidated. Furthermore, N-alkyl forms (e.g., N-methyl forms) of these are also included.

[0019] These natural ceramides may be optically active in the natural form (D(-)), in the unnatural form (L(+)), or a mixture of the natural and unnatural forms. The relative stereochemistry of the above compounds may be that of the natural form, or other unnatural forms, or a mixture thereof. In particular, one or more compounds selected from CERAMIDE1, CERAMIDE2, CERAMIDE3, CERAMIDE5, CERAMIDE6II (all INCI, 8th Edition) and those represented by the following formula are preferred.

[0020] [ka]

[0021] These may be either natural extracts or synthetic products, and commercially available products can be used. When using commercially available natural ceramides, one or more selected from Ceramide I, Ceramide III, Ceramide IIIA, Ceramide IIIB, Ceramide IIIC, Ceramide VI (all from Cosmo Farm Co., Ltd.), Ceramide TIC-001 (Takasago International Corporation), CERAMIDE II (Quest International Co., Ltd.), DS-Ceramide VI, DS-CLA-Phytoceramide, C6-Phytoceramide, DS-ceramide Y3S (DOOSAN Corporation), and CERAMIDE2 (Sederma Corporation) are preferred.

[0022] [ka]

[0023] Pseudoceramides are represented by general formula (2).

[0024] [ka]

[0025] [In the formula, R 5 X represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group or hydrogen atom having 10 to 22 carbon atoms, which may be substituted with a hydroxyl group; X 5 R represents a hydrogen atom, an acetyl group, or a glyceryl group; 6 R represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms, which may be substituted with a hydroxyl group or an amino group, or a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms, which may be substituted with a hydroxyl group, esterified to the ω-terminus of the hydrocarbon group; 7 This represents a hydrogen atom, or an alkyl group with a total of 1 to 30 carbon atoms, which may be substituted with a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, or an acetoxy group.

[0026] R 6 Particularly preferred are nonyl, tridecyl, pentadecyl, undecyl groups with linoleic acid ester-bonded to the ω position, pentadecyl groups with linoleic acid ester-bonded to the ω position, pentadecyl groups with 12-hydroxystearic acid ester-bonded to the ω position, and undecyl groups with methyl-branched isostearic acid amide-bonded to the ω position.

[0027] R 7 R 5 If is a hydrogen atom, it is an alkyl group having a total of 10 to 30 carbon atoms, preferably 12 to 20 carbon atoms, which may be substituted with a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, or an acetoxy group, and R 5 If is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 10 to 22 carbon atoms, which may be substituted with a hydroxyl group, it is preferable that it be a hydrogen atom or an alkyl group having a total of 1 to 8 carbon atoms, which may be substituted with a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, or an acetoxy group. 7 The hydroxyalkoxy group or alkoxy group is preferably one having 1 to 7 carbon atoms.

[0028] As a pseudo-ceramide represented by general formula (2), R is shown in the following formula.5 is a hexadecyl group, X 5 is a hydrogen atom, R 6 is a pentadecyl group, R 7 Those in which the group is a hydroxyethyl group (i.e., N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide); R 5 is a hexadecyl group, X 5 is a hydrogen atom, R 6 is a nonyl group, R 7 Preferably, one or more of those in which the group is a hydroxyethyl group (i.e., N-(hexadecyloxyhydroxypropyl)-N-hydroxyethyldecanamide) are selected, with the former being more preferred.

[0029] [ka]

[0030] The content of component (A) in the aerosol concentrate is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.075% by mass or more, even more preferably 0.1% by mass or more, and also preferably 15% by mass or less, more preferably 10% by mass or less, even more preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less. The specific range of the content of component (A) in the aerosol concentrate is preferably 0.001 to 15% by mass, more preferably 0.010 to 10% by mass, even more preferably 0.075 to 5.0% by mass, and even more preferably 0.1 to 3.0% by mass.

[0031] [Ingredient (B): Ionic surfactant] As the ionic surfactant for component (B), any of anionic surfactants, cationic surfactants, or amphoteric surfactants can be used.

[0032] Anionic surfactants include carboxylate types such as N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, polyoxyethylene alkyl ether carboxylic acids, acyl lactic acid, N-acyl methylalanine, N-acyl sarcosine, diacyl amino acids and their salts; sulfonate types such as alkanesulfonic acids, α-olefin sulfonic acids, α-sulfo fatty acid methyl esters, acyl isethionic acid, alkyl sulfosuccinic acid, N-acyl methyl taurine and their salts; alkyl sulfates, polyoxyethylene alkyl sulfates, alkyl ether sulfates, polyoxyethylene alkyl ether sulfates, and fats. It is preferable to include one or more selected from sulfate types such as acid alkanolamide sulfates and their salts; and phosphate types such as alkyl phosphates, polyoxyethylene alkyl ether phosphates and their salts. From the viewpoint of improving emulsification stability, it is preferable to include one or more selected from N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, diacyl glutamate lysine, alkyl sulfosuccinic acid, N-acylmethyl taurine, alkyl sulfates, polyoxyethylene alkyl sulfates, alkyl phosphates, polyoxyethylene alkyl ether phosphates and their salts.

[0033] Of these, it is preferable to include one or more selected from N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, diacyl glutamate lysine, alkyl sulfosuccinic acid, N-acylmethyl taurine, alkyl sulfate esters, polyoxyethylene alkyl sulfate esters, polyoxyethylene alkyl ether phosphate, and salts thereof. Furthermore, it is more preferable to include one or more selected from N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, diacyl glutamate lysine, alkyl sulfosuccinic acid, N-acylmethyl taurine, polyoxyethylene alkyl sulfate esters, polyoxyethylene alkyl ether phosphate, and salts thereof. It is even more preferable to include one or more selected from N-acyl amino acids, fatty acids, diacyl glutamate lysine, N-acylmethyl taurine, polyoxyethylene alkyl ether phosphate, and salts thereof, with N-acyl amino acids and N-acylmethyl taurine being more preferable, and it is even more preferable to include sodium N-stearoyl glutamate and sodium N-stearoyl-N-methyl taurine.

[0034] Examples of N-acylmethyltaurines and their salts include N-myristoyl-N-methyltaurine, N-lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine, and their salts. Examples of N-acylamino acids and their salts include N-acylglutamic acids such as N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid, and N-myristoyl-L-glutamic acid, and their salts. Examples of fatty acids and their salts include fatty acids with 12 to 24 carbon atoms such as lauric acid, palmitic acid, and stearic acid, and their salts. Examples of alkyl ether carboxylic acids and their salts include polyoxyethylene lauryl ether acetate and its salts. Examples of diacylglutamic acid lysine and its salts include dilauroylglutamic acid lysine and its salts. Examples of alkyl sulfosuccinic acids and their salts include di-2-ethylhexyl sulfosuccinic acid and its salts. Examples of alkyl sulfate esters and their salts include lauryl sulfate and its salts. Examples of polyoxyethylene alkyl sulfate esters and their salts include polyoxyethylene lauryl sulfate and its salts. Examples of alkyl phosphates and their salts include monomyristyl phosphate, monostearyl phosphate, di(C12-15)pareth-8-phosphate and their salts. Examples of polyoxyethylene alkyl phosphates and their salts include polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate and their salts.

[0035] Examples of salt structures that make up these salts include alkali metal salts such as sodium salts and potassium salts; basic amino acid salts such as L-arginine salts, L-histidine salts, and L-lysine salts; and alkanolamine salts such as triethanolamine salts. These anionic surfactants can be used individually or in combination of two or more.

[0036] The cationic surfactant preferably contains one or more selected from sphingosine salts, aliphatic amine salts, quaternary ammonium salts, DL-pyrrolidone carboxylates, alkylamidoamines, and their salts. More preferably, from the viewpoint of improving moisturizing effect and emulsion stability, it contains one or more selected from sphingosine salts, monoC12-24 alkyltrimethylammonium salts, diC12-24 alkyldimethylammonium salts, diacylethylhydroxyethylmonium methosulfate, acylarginine ethylpyrrolidone carboxylate, and alkylamidoamine salts. Even more preferably, it contains one or more selected from phytosphingosyl methyl ammonium salts, distearyldimethylammonium chloride, and behenamidopropyldimethylamine lactate.

[0037] Examples of mono-C12-24 alkyltrimethylammonium salts include lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, and behenyltrimethylammonium chloride. Examples of di-C12-24 alkyldimethylammonium salts include dilauryldimethylammonium chloride, distearyldimethylammonium chloride, and dibehenyldimethylammonium chloride. Examples of diacylethylhydroxyethylmonium methosulfate include dicocoylethylhydroxyethylmonium methosulfate. Examples of acylarginine ethylpyrrolidone carboxylate salts include cocoylarginine ethylpyrrolidone carboxylate. Examples of alkylamidoamine salts include N-(3-(dimethylamino)propyl)docosanamide (also known as behenamidopropyldimethylamine) and its salts. One or more of these cationic surfactants can be used.

[0038] Among the cationic surfactants used in the present invention, sphingosine salts are composed of sphingosine compounds and acidic substances. As sphingosine compounds, naturally derived sphingosine compounds or synthetic products having the same structure, and their derivatives (hereinafter referred to as natural-type sphingosine) or pseudo-type sphingosine compounds having a sphingosine structure (hereinafter referred to as pseudo-type sphingosine) are preferred.

[0039] Examples of natural sphingosine include natural sphingosine, dihydrosphingosine, phytosphingosine, sphingadienine, dehydrosphingosine, dehydrophytosphingosine, and their N-alkyl forms (e.g., N-methyl forms). These sphingosines may be the optically active natural form (D(+) form), the optically active unnatural form (L(-) form), or a mixture of natural and unnatural forms. The relative stereochemistry of the above compounds may be that of the natural form, or other unnatural forms, or a mixture thereof. Furthermore, PHYTOSPHINGOSINE (INCI name; 8th Edition) and those represented by the following formula are preferred.

[0040] [ka]

[0041] These can be either natural extracts or synthetic compounds, and commercially available products can be used. Examples of commercially available natural sphingosine include D-Sphingosine (4-Sphingenine) (SIGMA-ALDRICH), DS-phytosphingosine (DOOSAN), and phytosphingosine (Cosmofarm).

[0042] Specific examples of pseudo-sphingosine include the following pseudo-sphingosine(i) to (iv), and 1-(2-hydroxyethylamino)-3-isostearyloxy-2-propanol.

[0043] [ka]

[0044] As for sphingosine compounds, natural sphingosine, phytosphingosine, and pseudo-sphingosine are preferred, pseudo-sphingosine is more preferred, and pseudo-sphingosine(ii) and 1-(2-hydroxyethylamino)-3-isostearyloxy-2-propanol are even more preferred.

[0045] Examples of acidic substances that constitute salts with these natural sphingosine, phytosphingosine, and pseudo-sphingosine include acidic amino acids such as glutamic acid and aspartic acid; inorganic acids such as phosphoric acid and hydrochloric acid; monocarboxylic acids such as acetic acid; dicarboxylic acids such as succinic acid; and oxycarboxylic acids such as citric acid, lactic acid, and malic acid. Among these, succinate, lactate, and glutamate salts of natural sphingosine, phytosphingosine, or pseudo-sphingosine (pseudo-sphingosine(II), 1-(2-hydroxyethylamino)-3-isostearyloxy-2-propanol) are preferred, glutamate salts of natural sphingosine, phytosphingosine, or pseudo-sphingosine are more preferred, and phytosphingosine glutamate salts are even more preferred.

[0046] Examples of amphoteric surfactants include phospholipids, alkyldimethylamine oxides, alkylcarboxybetaines, alkylsulfobetaines, amide amino acid salts, and alkylamidopropyl betaines. Among these, alkylamidopropyl betaines, soybean phospholipids, and hydrogenated soybean phospholipids are preferred, with hydrogenated soybean phospholipids being even more preferred.

[0047] The content of component (B) in the aerosol concentrate is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.075% by mass or more, even more preferably 0.15% by mass or more, and also preferably 5.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 0.75% by mass or less, and even more preferably 0.50% by mass or less. The specific range of the content of component (B) in the aerosol concentrate is preferably 0.01 to 5.0% by mass, more preferably 0.05 to 2.0% by mass, even more preferably 0.075 to 0.75% by mass, and even more preferably 0.15 to 0.50% by mass.

[0048] The mass ratio (A) / (B) of component (A) to component (B) in the aerosol stock solution is preferably 0.003 or higher, more preferably 0.03 or higher, even more preferably 0.3 or higher, and also preferably 100 or lower, more preferably 30 or lower, and even more preferably 15 or lower, from the viewpoint of improving emulsification stability, moisturizing effect, and applicability. The specific range of the mass ratio (A) / (B) of component (A) to component (B) in the aerosol stock solution is preferably 0.003 to 100, more preferably 0.03 to 30, and even more preferably 0.3 to 15.

[0049] [Component (C): Water-soluble polymer] The water-soluble polymer of component (C) is not limited as long as it is commonly used in topical skin preparations, and examples include plant-derived polymers, microbial polymers, mucopolysaccharides, cellulose-based polymers, starch-based polymers, vinyl-based polymers, acrylic polymers, and polyoxyethylene-based polymers. The weight-average molecular weight of the water-soluble polymer of component (C) is preferably 10,000 or more. The weight-average molecular weight is measured using a gel permeation chromatography (GPC)-multi-angle laser light scattering detection (MALLS) system with polyethylene oxide as the standard substance.

[0050] Examples of plant-derived polymers include gum arabic, locust bean gum, guar gum, karaya gum, carrageenan, pectin, agar, and starch (rice, corn, potato, wheat). Examples of microbial polymers include xanthan gum and gellan gum. Examples of mucopolysaccharides include hyaluronic acid, tuberose polysaccharide, and Tremella fuciformis polysaccharide. Examples of cellulosic polymers include methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose stearoxyl ether, nitrocellulose, sodium cellulose sulfate, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, and sodium hydroxypropyl sulfonate. Examples of starch-derived polymers include carboxymethyl starch and methylhydroxypropyl starch. Examples of vinyl-derived polymers include polyvinyl methyl ether and polyvinylpyrrolidone. Examples of acrylic polymers include alkyl-modified carboxyvinyl polymers, carboxyvinyl polymers, sodium polyacrylate, polyethyl acrylate, polyacrylamide, acrylic acid / alkyl acrylate copolymer, acrylic acid / alkyl methacrylate copolymer, (sodium acrylate / sodium acryloyldimethyl taurate) copolymer, polyacrylate crosspolymer-6, N,N-dimethylaminoethyl methacrylate diethyl sulfate / N,N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. Examples of polyoxyethylene polymers include polyethylene oxide. Of these, microbial polymers, cellulose polymers, and acrylic polymers are preferred from the viewpoint of improving emulsification stability and coatability.

[0051] As microbial polymers, xanthan gum and gellan gum are preferred, with xanthan gum being more preferred. As cellulosic polymers, hydroxypropyl methylcellulose, hydroxyethylcellulose, and hydroxypropyl methylcellulose stearoxy ether are preferred, with hydroxypropyl methylcellulose and hydroxypropyl methylcellulose stearoxy ether being more preferred. As acrylic polymers, alkyl-modified carboxyvinyl polymers, carboxyvinyl polymers, acrylic acid / (meth)acrylate alkyl copolymers, N,N-dimethylaminoethyl methacrylate diethyl sulfate / N,N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymers, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymers are preferred, with (acrylic acid / alkyl acrylate (C10-30)) copolymers being more preferred. Here, the (acrylic acid / alkyl (C10-30) acrylate) copolymer is a copolymer of C10-30 alkyl acrylic acid and acrylic acid, methacrylic acid, or a lower alkyl ester thereof, crosslinked with sucrose allyl ether or pentaerythritol allyl ether. Commercial products such as Pemlen TR-1, Pemlen TR-2, Carbopol ETD2020, Carbopol 1342, and Carbopol 1382 (all from Lubrizol Advanced Materials) can be used.

[0052] Of these, component (C) preferably contains one or more selected from hydroxypropyl methylcellulose, hydroxypropyl methylcellulose stearoyl ether, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, acrylic acid / (meth)acrylate alkyl copolymer, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, and more preferably contains one or more selected from hydroxypropyl methylcellulose, (acrylic acid / alkyl acrylate (C10-30)) copolymer, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer.

[0053] The content of component (C) in the aerosol concentrate is preferably 0.010% by mass or more, more preferably 0.025% by mass or more, even more preferably 0.050% by mass or more, even more preferably 0.075% by mass or more, and also preferably 2.0% by mass or less, more preferably 0.60% by mass or less, even more preferably 0.30% by mass or less, and even more preferably 0.20% by mass or less. The specific range of the content of component (C) in the aerosol concentrate is preferably 0.010 to 2.0% by mass, more preferably 0.025 to 0.60% by mass, even more preferably 0.050 to 0.30% by mass, and even more preferably 0.075 to 0.20% by mass.

[0054] The mass ratio (A) / (C) of component (A) to component (C) in the aerosol stock solution is preferably 0.01 or higher, more preferably 0.10 or higher, even more preferably 0.50 or higher, even more preferably 0.75 or higher, and even more preferably 1.0 or higher, and also preferably 150 or lower, more preferably 100 or lower, even more preferably 40 or lower, even more preferably 30 or lower, and even more preferably 20 or lower. The specific range of the mass ratio (A) / (C) of component (A) to component (C) in the aerosol stock solution is preferably 0.01 to 150, more preferably 0.10 to 100, even more preferably 0.50 to 40, even more preferably 0.75 to 30, and even more preferably 1.0 to 20.

[0055] The mass ratio (C) / (B) of component (C) to component (B) in the aerosol stock solution is preferably 0.01 or higher, more preferably 0.05 or higher, even more preferably 0.10 or higher, even more preferably 0.20 or higher, and also preferably 10 or lower, more preferably 5 or lower, even more preferably 1.5 or lower, and even more preferably 0.8 or lower. The specific range of the mass ratio (C) / (B) of component (C) to component (B) in the aerosol stock solution is preferably 0.01 to 10, more preferably 0.05 to 5, even more preferably 0.10 to 1.5, and even more preferably 0.20 to 0.8.

[0056] [Component (D): Water] The water content of component (D) in the aerosol stock solution is preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 70% by mass or more, even more preferably 75% by mass or more, and also preferably 98% by mass or less, more preferably 95% by mass or less, even more preferably 90% by mass or less, and even more preferably 85% by mass or less. The specific range of the content of component (D) in the aerosol stock solution is preferably 50 to 98% by mass, more preferably 60 to 95% by mass, even more preferably 70 to 90% by mass, and even more preferably 75 to 85% by mass.

[0057] [Nonionic surfactants] The aerosol concentrate may further contain a nonionic surfactant. Examples of nonionic surfactants include sorbitan fatty acid esters (e.g., sorbitan monostearate), glycerin fatty acid esters (e.g., glyceryl monostearate), polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyethylene glycol fatty acid esters, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene(20) sorbitan monostearate (polysorbate 60)), polyoxyethylene alkyl ethers, alkyl glyceryl ethers, and polyoxyethylene alkyl ethers. Examples include ethylene sorbitol fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid esters, polyoxyethylene phytostanol ether, polyoxyethylene phytosterose ether, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene-modified organopolysiloxane, and polyoxyalkylene-alkyl copolymerized organopolysiloxane.

[0058] Of these, sorbitan fatty acid esters, glycerin fatty acid esters, alkyl glyceryl ethers, and polyoxyethylene sorbitan fatty acid esters are preferred from the viewpoint of improving moisturizing effect and emulsification stability; sorbitan C12-22 fatty acid esters, glycerin mono-C12-22 fatty acid esters, mono-C12-22 alkyl glyceryl ethers, and polyoxyethylene sorbitan C12-22 fatty acid esters are more preferred; and polyoxyethylene sorbitan monostearate and sorbitan monostearate are even more preferred.

[0059] [Other optional ingredients] The aerosol concentrate may further contain liquid oils at 25°C, polyhydric alcohols, thickeners, preservatives, powders, ethanol, antioxidants, pigments, pH adjusters, fragrances, humectants, blood circulation promoters, cooling agents, antiperspirants, disinfectants, whitening agents, anti-inflammatory agents, skin activators, etc. These agents are not limited to their individual uses; they can be repurposed for other uses or used in combination with other uses depending on the purpose. For example, an antiperspirant may be used as a fragrance, or it may be used to provide the combined effects of both an antiperspirant and a fragrance.

[0060] Examples of liquid oils at 25°C include hydrocarbon oils, silicone oils, ester oils, ether oils, and fluorine oils. From the viewpoint of improving emulsification stability and applicability, hydrocarbon oils, ester oils, and silicone oils are preferred, hydrocarbon oils, monoester oils, triester oils, and silicone oils are more preferred, and monoester oils, triester oils, and silicone oils are even more preferred. Specifically, examples include linear or branched hydrocarbon oils such as light isoparaffin, liquid paraffin, liquid isoparaffin, squalane, and squalene; silicone oils such as cyclomethicone, dimethicone, trisiloxane methyltrimethicone, ethyltrisiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, and higher alcohol-modified organopolysiloxane; monoester oils such as isononyl isononanoate, isotridecyl isononanoate, and alkyl benzoate (C12-15), which is an ester of benzoic acid with an aliphatic alcohol having 12 to 15 carbon atoms; diester oils such as neopentyl glycol dicaprate; triester oils such as tri(caprylic / capric acid) glyceryl and triglyceryl 2-ethylhexanoate; ether oils such as alkyl-1,3-dimethylbutyl ether, dicaprylyl ether, and dicaprylyl ether; and fluorine oils such as fluoropolyether and perfluoroalkyl ether silicone. These may also be derived from plants or other natural sources. Furthermore, liquid UV absorbers are also included in liquid oils at 25°C.

[0061] From the viewpoint of improving usability, the content of liquid oil at 25°C in the aerosol concentrate is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, and also preferably 5.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably 1.0% by mass or less. The specific range of the content of liquid oil at 25°C in the aerosol concentrate is preferably 0.01 to 5.0% by mass, more preferably 0.05 to 3.0% by mass, and even more preferably 0.1 to 1.0% by mass.

[0062] As polyhydric alcohols, any polyhydric alcohol commonly used in cosmetics is acceptable, for example, dihydric alcohols such as ethylene glycol, propylene glycol, propanediol, 1,3-butylene glycol, 1,3-propanediol, dipropylene glycol, polyethylene glycol, and polypropylene glycol; and trihydric or higher polyhydric alcohols such as glycerin and sorbitol. Of these, from the viewpoint of improving applicability, propylene glycol, propanediol, 1,3-butylene glycol, 1,3-propanediol, and dipropylene glycol are more preferred as dihydric polyhydric alcohols, glycerin is more preferred as a trihydric or higher polyhydric alcohol, 1,3-propanediol, dipropylene glycol, and glycerin are even more preferred, and the inclusion of glycerin is even more preferred.

[0063] The polyhydric alcohol content in the aerosol concentrate is preferably 1% by mass or more, more preferably 2% by mass or more, even more preferably 5% by mass or more, even more preferably 10% by mass or more, and also preferably 50% by mass or less, more preferably 40% by mass or less, even more preferably 30% by mass or less, and even more preferably 20% by mass or less. 1 to 50% by mass is preferred, 2 to 40% by mass is more preferred, 5 to 30% by mass is even more preferred, and 10 to 20% by mass is even more preferred.

[0064] The pH adjusting agent may contain one or more pH adjusting agents selected from the group consisting of organic acids, organic acid salts, amino acids, amino acid salts, amines, and inorganic acids, inorganic acid salts, and inorganic bases. Examples of organic acids include glycolic acid, citric acid, malic acid, succinic acid, tartaric acid, and lactic acid, and examples of their salts include potassium salts and sodium salts. Examples of amino acids include glutamic acid, aspartic acid, arginine, and lysine, and examples of their salts include sodium salts, hydrochloride salts, and succinate salts. Examples of amines include aliphatic amines such as monoethanolamine, triethanolamine, methylamine, ethylamine, trimethylamine, triethylamine, ethylenediamine, and tetramethylethylenediamine. Examples of inorganic acids include phosphoric acid, and examples of inorganic acid salts include potassium dihydrogen phosphate and disodium hydrogen phosphate. Examples of inorganic bases include alkali metal hydroxides such as lithium hydroxide, sodium hydroxide, and potassium hydroxide. Of these, amino acids are preferred from the viewpoint of moisturizing properties, and arginine is more preferred.

[0065] ● Propellant [Component (E): Carbon dioxide] In this invention, the propellant contains carbon dioxide, component (E). In addition to carbon dioxide, other propellants can be used in combination. Examples of propellants other than carbon dioxide include liquefied petroleum gas (ethane, propane, ethylene, isobutane, n-butane, propylene, etc., and mixtures thereof (e.g., mixtures of isobutane and propane, propane and butane, etc.)), ether-based propellants (dimethyl ether, etc.), fluorocarbons (fluorocarbons, chlorofluorocarbons, bromochlorofluorocarbons, etc.), compressed gases (nitrogen, air, mixtures thereof, etc.), and fluorocarbon gases (monochlorodifluoroethane, tetrafluoroethane, etc.), with nitrogen, dimethyl ether, and liquefied petroleum gas being particularly preferred. When using other propellants in combination with carbon dioxide, component (E), any of them can be used alone or in combination of two or more.

[0066] When using propellants other than carbon dioxide (component (E)) as a propellant, from the viewpoint of not impairing the effect of carbon dioxide, the ratio of carbon dioxide (component (E)) in the total propellant is preferably 20% or more, more preferably 40% or more, even more preferably 60% or more, and even more preferably 80% or more, based on volume in the gaseous state (1013.25 hPa, 25°C).

[0067] ● Carbonated aerosol topical skin preparation The carbonated aerosol skin preparation of the present invention can be manufactured by preparing an aerosol stock solution containing components (A) to (D) and filling it into a pressure-resistant container together with a propellant containing component (E). The preferred form of discharge is a foam type, where the solution is dispensed as a foam.

[0068] The ratio of (E) carbon dioxide to 100 parts by mass of aerosol stock is preferably 0.01 parts by mass or more, more preferably 0.10 parts by mass or more, even more preferably 0.125 parts by mass or more, even more preferably 0.25 parts by mass or more, even more preferably 0.5 parts by mass or more, even more preferably 1.0 part by mass or more, and also preferably 5.0 parts by mass or less, more preferably 3.0 parts by mass or less.

[0069] Furthermore, the mass ratio (E) / (A) of component (E) to component (A) in the carbonated aerosol skin topical preparation of the present invention is preferably 0.005 or higher, more preferably 0.10 or higher, even more preferably 0.2 or higher, and also preferably 3000 or lower, more preferably 300 or lower, and even more preferably 30 or lower, from the viewpoint of improving the emulsification stability and applicability of component (A).

[0070] The pH of the carbonated aerosol topical skin preparation of the present invention immediately after dispensing is preferably 7.0 or lower, more preferably 6.5 or lower, and even more preferably 6.0 or lower, from the viewpoint of emulsification stability. Furthermore, from the viewpoint of skin irritation, it is preferably 2.0 or higher, more preferably 3.0 or higher, and even more preferably 4.0 or higher. In this invention, the pH immediately after dispensing refers to the pH measured 1 minute after dispensing from the aerosol container under a 25°C environment.

[0071] When the carbonated aerosol skin topical preparation of the present invention is of the foam type, the viscosity of the dispensed foam is preferably 0.2 Pa·s or more, more preferably 0.5 Pa·s or more, more preferably 2.0 Pa·s or more, even more preferably 5.0 Pa·s or more, and also preferably 30 Pa·s or less, more preferably 20 Pa·s or less, and even more preferably 10 Pa·s or less, from the viewpoint of improving applicability.

[0072] [How to use] The carbonated aerosol topical skin preparation of the present invention is applied in an appropriate amount to the skin, especially to the skin of the entire body excluding the scalp, preferably to the face, body, limbs, etc., more preferably to the skin of the hands and feet. It may be applied by taking it in your hand and spreading it on the target area, or it may be dispensed directly onto the target area. In the case of the foam type, it is preferable to take it in your hand and apply it without crushing the foam. It is especially preferable to apply it to areas with thick stratum corneum and prone to dryness, such as the hands, feet, fingers, heels, elbows, and knees. The amount to be applied is preferably about 1 g for both hands.

[0073] With respect to the embodiments described above, preferred embodiments of the present invention are further disclosed below.

[0074] <1> A carbonated aerosol skin preparation comprising an aerosol concentrate containing the following ingredients (A) to (D) and a propellant containing ingredient (E). (A) Ceramide lipids (B) Ionic surfactants (C) Water-soluble polymer (D) Water (E) Carbon dioxide

[0075] <2> The ceramide lipid of component (A) preferably comprises one or more selected from those represented by the following general formulas (1) or (2). <1> The carbonated aerosol skin preparation described above.

[0076] [ka]

[0077] [In the formula, R 1 represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms, which may be substituted with a hydroxyl group; Z 1 X indicates a methylene group or methine group; 1 , X 2 , and X 3 Each of these independently represents a hydrogen atom, a hydroxyl group, or an acetoxy group; X 4 It either represents a hydrogen atom or, together with an adjacent oxygen atom, forms an oxo group (however, Z 1 When it is a methine group, X 1 and X 2 One of them is a hydrogen atom, and the other does not exist. 4 When X forms an oxo group, 3 It does not exist. );R 2 R indicates a hydroxymethyl group or an acetoxymethyl group; 3 R represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; 4 represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms, which may be substituted with a hydroxyl group, or a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms, which may be substituted with a hydroxyl group, esterified to the ω-terminus of the alkyl group; the dashed line indicates that it may be an unsaturated bond.

[0078] [ka]

[0079] [In the formula, R 5X represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group or hydrogen atom having 10 to 22 carbon atoms, which may be substituted with a hydroxyl group; X 5 R represents a hydrogen atom, an acetyl group, or a glyceryl group; 6 R represents a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms, which may be substituted with a hydroxyl group or an amino group, or a linear or branched saturated or unsaturated fatty acid having 8 to 22 carbon atoms, which may be substituted with a hydroxyl group, esterified to the ω-terminus of the hydrocarbon group; 7 This represents a hydrogen atom, or an alkyl group with a total of 1 to 30 carbon atoms, which may be substituted with a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, or an acetoxy group.

[0080] <3> The content of component (A) in the aerosol concentrate is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.075% by mass or more, even more preferably 0.1% by mass or more, and also preferably 15% by mass or less, more preferably 10% by mass or less, even more preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less. <1> or <2> The carbonated aerosol skin preparation described above.

[0081] <4> Component (B) preferably comprises at least one selected from anionic surfactants selected from N-acyl amino acids, fatty acids, alkyl ether carboxylic acids, diacyl glutamate lysine, alkyl sulfosuccinic acid, N-acyl methyl taurine, alkyl sulfate esters, polyoxyethylene alkyl sulfate esters, alkyl phosphate esters, polyoxyethylene alkyl ether phosphate and their salts, cationic surfactants selected from sphingosine salts, aliphatic amine salts, quaternary ammonium salts, DL-pyrrolidone carboxylate salts, alkylamidoamines and their salts, and amphoteric surfactants selected from alkylamidopropyl betaine, soybean phospholipids and hydrogenated soybean phospholipids. <1> ~ <3> A carbonated aerosol skin preparation described in any one of the items.

[0082] <5> The content of component (B) in the aerosol concentrate is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.075% by mass or more, even more preferably 0.15% by mass or more, and also preferably 5.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 0.75% by mass or less, and even more preferably 0.50% by mass or less. <1> ~ <4> A carbonated aerosol skin preparation described in any one of the items.

[0083] <6> The mass ratio (A) / (B) of component (A) to component (B) in the aerosol concentrate is preferably 0.003 or higher, more preferably 0.03 or higher, even more preferably 0.3 or higher, and also preferably 100 or lower, more preferably 30 or lower, and even more preferably 15 or lower. <1> ~ <5> A carbonated aerosol skin preparation described in any one of the items.

[0084] <7> Component (C) preferably comprises one or more selected from plant-derived polymers, microbial polymers, mucopolysaccharides, cellulosin-based polymers, starch-based polymers, vinyl-based polymers, acrylic polymers, and polyoxyethylene-based polymers, more preferably one or more selected from hydroxypropyl methylcellulose, hydroxypropyl methylcellulose stearoxy ether, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, acrylic acid / (meth)acrylate alkyl copolymer, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. <1> ~ <6> A carbonated aerosol skin preparation described in any one of the items.

[0085] <8> The content of component (C) in the aerosol concentrate is preferably 0.010% by mass or more, more preferably 0.025% by mass or more, even more preferably 0.050% by mass or more, even more preferably 0.075% by mass or more, and also preferably 2.0% by mass or less, more preferably 0.60% by mass or less, even more preferably 0.30% by mass or less, and even more preferably 0.20% by mass or less. <1> ~ <7> A carbonated aerosol skin preparation described in any one of the items.

[0086] <9> The mass ratio (A) / (C) of component (A) to component (C) in the aerosol stock solution is preferably 0.01 or higher, more preferably 0.10 or higher, even more preferably 0.50 or higher, even more preferably 0.75 or higher, even more preferably 1.0 or higher, and also preferably 150 or lower, more preferably 100 or lower, even more preferably 40 or lower, even more preferably 30 or lower, and even more preferably 20 or lower. <1> ~ <8> A carbonated aerosol skin preparation described in any one of the items.

[0087] <10> The mass ratio (C) / (B) of component (C) to component (B) is preferably 0.01 or higher, more preferably 0.05 or higher, even more preferably 0.10 or higher, even more preferably 0.20 or higher, and also preferably 10 or lower, more preferably 5 or lower, even more preferably 1.5 or lower, and even more preferably 0.8 or lower. <1> ~ <9> A carbonated aerosol skin preparation described in any one of the items.

[0088] <11> The water content of component (D) in the aerosol concentrate is preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 70% by mass or more, even more preferably 75% by mass or more, and also preferably 98% by mass or less, more preferably 95% by mass or less, even more preferably 90% by mass or less, and even more preferably 85% by mass or less. <1> ~ <10> A carbonated aerosol skin preparation described in any one of the items.

[0089] <12> Furthermore, the aerosol concentrate contains polyhydric alcohols. <1> ~ <11> A carbonated aerosol skin preparation described in any one of the items.

[0090] <13> The polyhydric alcohol is preferably one or more selected from ethylene glycol, propylene glycol, propanediol, 1,3-butylene glycol, 1,3-propanediol, dipropylene glycol, polyethylene glycol, polypropylene glycol, glycerin, and sorbitol; more preferably one or more selected from propylene glycol, propanediol, 1,3-butylene glycol, 1,3-propanediol, dipropylene glycol, and glycerin; even more preferably one or more selected from 1,3-propanediol, dipropylene glycol, and glycerin; and even more preferably glycerin. <12> The carbonated aerosol skin preparation described above.

[0091] <14> The polyhydric alcohol content in the aerosol concentrate is preferably 1% by mass or more, more preferably 2% by mass or more, even more preferably 5% by mass or more, even more preferably 10% by mass or more, and also preferably 50% by mass or less, more preferably 40% by mass or less, even more preferably 30% by mass or less, and even more preferably 20% by mass or less. <12> or <13> The carbonated aerosol skin preparation described above.

[0092] <15> The mass ratio (E) / (A) of component (E) to component (A) is preferably 0.005 or more, more preferably 0.10 or more, even more preferably 0.2 or more, and also preferably 3000 or less, more preferably 300 or less, and even more preferably 30 or less. <1> ~ <14> A carbonated aerosol skin preparation described in any one of the items.

[0093] <16> The ratio of component (E) to 100 parts by mass of aerosol concentrate is preferably 0.01 parts by mass or more, more preferably 0.10 parts by mass or more, even more preferably 0.125 parts by mass or more, even more preferably 0.25 parts by mass or more, even more preferably 0.5 parts by mass or more, and even more preferably 1.0 part by mass or more, and also preferably 5.0 parts by mass or less, more preferably 3.0 parts by mass or less. <1> ~ <15> A carbonated aerosol skin preparation described in any one of the items.

[0094] <17> The pH immediately after discharge is preferably 7.0 or lower, more preferably 6.5 or lower, even more preferably 6.0 or lower, and also preferably 2.0 or higher, more preferably 3.0 or higher, and even more preferably 4.0 or higher. <1> ~ <16> A carbonated aerosol skin preparation described in any one of the items. [Examples]

[0095] Examples 1-51, Comparative Examples 1-5 Aerosol concentrates were prepared according to the formulations shown in Tables 1-8. The resulting compositions were filled into pressure-resistant containers (100 mL aerosol glass test bottles), sealed, and then pressurized with component (E) to produce aerosol topical skin preparations. The high-temperature storage stability of these carbonated aerosol topical skin preparations was evaluated according to the following methods and criteria.

[0096] <Method for evaluating high-temperature storage stability> After storing the aerosol compatible bottles in a constant temperature bath at 45°C for 30 days, they were returned to 25°C, and then their appearance and dispensing performance were checked according to the following evaluation criteria. <Evaluation Criteria> A: No change, can be dispensed. B: Slightly thickens but remains fluid and can be dispensed. C: Thickens but remains fluid and can be dispensed. D: Fluidity decreases, but no precipitation occurs, and it can be dispensed. E: Dispensing impossible due to precipitation or gelation.

[0097] <Method for evaluating foam viscosity> The foam was dispensed to a full volume into a 20 mL plastic cup and measured using a VISCOMETER TVB10 viscometer (25°C, rotor No. 3, 12 rpm, 10 s).

[0098] <Measurement of pH immediately after dispensing> Under 25°C conditions, approximately 5g of the aerosol topical skin preparation was dispensed from a pressure-resistant container and placed into a 20mL plastic cup. One minute after dispensing, the pH was measured using a pH meter (LAQUA F-74).

[0099] <Method for evaluating moisturizing effect> Approximately 1g of the aerosol topical skin preparation was dispensed onto the inner side of the upper arm and spread with the palm of the hand. The moisturizing effect after application was evaluated by five expert panelists on a scale of 2 points for very moisturizing, 1 point for moisturizing, and 0 points for not moisturizing at all. The total scores are shown in the table.

[0100] <Method for evaluating applicability> Approximately 1g of the aerosol topical skin preparation was dispensed onto the inner side of the upper arm, and its spreadability was evaluated by five expert panelists on a scale of easy to spread (2 points), somewhat easy to spread (1 point), and difficult to spread (0 points). The total scores are shown in the table.

[0101] <Method for evaluating penetration> Approximately 1g of the aerosol topical skin preparation was dispensed onto the inner side of the upper arm and spread on the palm of the hand. The ease with which the preparation was absorbed into the skin was evaluated by five expert panelists on a scale of 2 points for easy absorption, 1 point for moderate absorption, and 0 points for poor absorption. The total scores are shown in the table.

[0102] <Method for evaluating the sustained moisturizing effect on excessively dry skin> Five expert panelists with dry shins washed their shins five times with soap, then dispensed approximately 1g of aerosol topical skin preparation onto their shins and spread it with their hands. After spending one hour in a room at 20°C and 40% humidity, they evaluated the moistness of their shins on a scale of 2 points for very moist, 1 point for moist, and 0 points for not moist. The total scores are shown in the table.

[0103] [Table 1]

[0104] [Table 2]

[0105] [Table 3]

[0106] [Table 4]

[0107] [Table 5]

[0108] [Table 6]

[0109] [Table 7]

[0110] [Table 8]

[0111] *1: Sphingolipid E ​​(manufactured by Kao Corporation) *2: Nikkor SMT (manufactured by Nikko Chemicals Co., Ltd.) *3: Leodor TW-S120V (manufactured by Kao Corporation) *4: Leodor SP-S10V (manufactured by Kao Corporation) *5: PEMULEN TR1 (manufactured by Lubrizol Advanced Materials) *6: San Jerose 90L (manufactured by Daido Chemical Industries Co., Ltd.) *7: Carbopol 980 (manufactured by Lubrizol Advanced Materials) *8: LIPIDURE-PMB (manufactured by NOF Corporation) *9: Metrozes 90SH15000 (manufactured by Shin-Etsu Chemical Co., Ltd.) *10: Keldent (manufactured by DSP Gokyo Food & Chemical Co., Ltd.) *11: Polymer KG30 (manufactured by Kao Corporation) *12: Phytosphingosine (manufactured by Evonik Nutrition & Care) *13: VARISOFT TA 100 (manufactured by Evonik Nutrition & Care) *14: NIKKOL Amidoamine MPB PLUS (manufactured by Nikko Chemicals Co., Ltd.) *15: Amisoft HS-11P (manufactured by Ajinomoto Co., Inc.) *16: COATSOME NC-21 (manufactured by NOF Corporation)

Claims

1. A carbonated aerosol skin preparation comprising an aerosol concentrate containing the following components (A) to (D) and a propellant containing component (E), The content of component (A) is 0.075 to 5.0% by mass. The mass ratio (A) / (B) of component (A) to component (B) is between 0.2 and 15. The mass ratio (A) / (C) of component (A) to component (C) is 0.01 or more and 40 or less. The mass ratio (C) / (B) of component (C) to component (B) is 0.20 or more and 0.8 or less. Carbonated aerosol skin preparation. (A) Ceramide lipids (B) Ionic surfactant selected from the following (B1) anionic surfactant, (B2) cationic surfactant, and (B3) amphoteric surfactant. (B1) Anionic surfactant comprising one or more selected from N-acyl amino acids, N-acylmethyl taurine, and their salts. (B2) Cationic surfactant containing one or more selected from sphingosine salts and quaternary ammonium salts (B3) Amphoteric surfactant selected from hydrogenated soybean phospholipids (C) A water-soluble polymer comprising one or more selected from hydroxypropyl methylcellulose, hydroxypropyl methylcellulose stearoyl ether, carboxyvinyl polymer, acrylic acid / (meth)acrylate alkyl copolymer, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. (D) Water (E) Carbon dioxide

2. The carbonated aerosol skin preparation according to claim 1, wherein the content of component (B) in the aerosol concentrate is 0.01% by mass or more and 5.0% by mass or less.

3. The carbonated aerosol skin preparation according to claim 1 or 2, wherein the content of component (C) in the aerosol concentrate is 0.010% by mass or more and 2.0% by mass or less.

4. A carbonated aerosol skin preparation according to any one of claims 1 to 3, wherein the content of component (D) in the aerosol concentrate is 75% by mass or more and 85% by mass or less.

5. Furthermore, the carbonated aerosol skin preparation according to any one of claims 1 to 4, which contains a polyhydric alcohol in the aerosol concentrate.

6. A carbonated aerosol skin preparation according to any one of claims 1 to 5, wherein the mass ratio (E) / (A) of component (E) to component (A) is 0.25 or more and 30 or less.

7. The carbonated aerosol skin preparation according to any one of claims 1 to 6, wherein the ratio of component (E) to 100 parts by mass of the aerosol concentrate is 0.01 parts by mass or more and 5.0 parts by mass or less.

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