Cleansing composition

Abstract

To provide alcohol-free cleansing compositions for cleaning dental appliances.SOLUTION: A dental appliance cleansing composition comprises (a) fatty acid isopropyl ester, (b) polyoxyethylene sorbitan ester, (c) second sorbitan ester, wherein the cleansing composition does not contain methanol, ethanol or isopropyl alcohol. A dental appliance cleansing wipe is impregnated with the composition. Also provided is use of the dental appliance cleansing composition or wipe for cleaning dental appliances and dentures.SELECTED DRAWING: None

Description

【Technical Field】 【0001】 The present invention relates to novel dental appliance cleansing compositions, particularly alcohol-free compositions. The present invention also relates to dental appliance wipes impregnated with the cleansing composition and its use in the cleaning of removable dental appliances. 【Background Art】 【0002】 Many wearers of removable dental appliances complain that they have to clean them frequently throughout the day. Cleaning is particularly common after meals, where wearers often experience food particles trapped under the dental appliance, which can be irritating and uncomfortable. To remove food particles, wearers generally use a toothbrush or rinse the dental appliance with water. Both approaches require water and may require removal of the dental appliance, which is inconvenient when not at home. Further, repeated brushing of dentures with toothpaste has been found to cause scratches on denture acrylic (Kiesow et al., Journal of Prosthetic Dentistry, 2016, Vol. 115, No. 2, pp. 189-198). 【0003】 Denture wearers are known to use various cleansing methods, including the use of mouthwashes containing alcohol (ethanol) (Axe AS et al., Journal of Prosthetic Dentistry. 2016 Feb;115(2):183-8). However, the use of both mouthwashes containing alcohol and isopropyl alcohol (IPA) has been found to cause damage to denture materials (Kiesow et al., Journal of Prosthetic Dentistry, 2016, Vol. 115, No. 2, pp. 189-198). Further, the use of alcohol may also be undesirable for some wearers of dental appliances, for example, for cultural or religious reasons, while compositions containing alcohol may be undesirable for children wearing orthodontic retainers, for example. 【Prior Art Documents】 [Non-patent literature] 【0004】 [Non-Patent Document 1] Kiesow et al., Journal of Prosthetic Dentistry, 2016, Vol. 115, No. 2, pp. 189-198 [Non-Patent Document 2] Ax AS et al., Journal of Prosthetic Dentistry.2016 Feb;115(2):183~8 [Overview of the project] [Problems that the invention aims to solve] 【0005】 Therefore, there is a need for an alternative cleansing method that does not require water or rinsing, does not damage denture materials, and can be used individually when not at home. Since Kiesow et al. have shown that alcohol causes damage to the polymethyl methacrylate (PMMA) component of dentures, an alcohol-free cleansing composition is also desirable. 【0006】 U.S. Patent No. 8,632,636 discloses a wet wipe for cleaning removable dental instruments, which comprises a physiologically acceptable cleansing composition comprising a water-insoluble substrate and ethyl alcohol. [Means for solving the problem] 【0007】 In one aspect, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) Second sorbitan ester A dental instrument cleansing composition comprising, The present invention provides a dental instrument cleaning composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0008】 In another embodiment, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) Second sorbitan ester A dental instrument cleansing composition comprising, This invention provides a dental instrument cleaning composition that does not contain alcohol. 【0009】 In another embodiment, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) Second sorbitan ester A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0010】 In another embodiment, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) Second sorbitan ester A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain alcohol. 【0011】 In another embodiment, the present invention provides the use of the dental instrument cleansing composition or the dental instrument wipes specified above for cleaning dental instruments. [Modes for carrying out the invention] 【0012】 The composition of the present invention has been found to provide effective cleaning of dental instruments and significant removal of microorganisms while minimizing damage to dental instrument materials. 【0013】 The composition of the present invention includes an isotropic microemulsion chassis with high solvation ability, which can be easily dispersed in water, is orally acceptable, has a high cost-effectiveness, and contains materials that are easily supplied. The microemulsion exhibits extremely low interfacial tension characteristics and has a large interfacial area, so it can be useful for cleaning and microbial removal. 【0014】 In particular, the present invention a) Isopropyl fatty acid ester, b) Polyoxyethylene sorbitan ester, and c) A second sorbitan ester A dental instrument cleansing composition containing Provided is a dental instrument cleansing composition that does not contain methanol, ethanol, and isopropyl alcohol. 【0015】 In another aspect, the present invention a) Isopropyl fatty acid ester, b) Polyoxyethylene sorbitan ester, and c) A second sorbitan ester A dental instrument cleansing composition containing Provided is a dental instrument cleansing composition that does not contain alcohol. [[ID=​​​​​​​​​​​​​​​​​​​​a) Isopropyl fatty acid esters selected from isopropyl palmitate, isopropyl myristate, and combinations thereof, b) Polyoxyethylene sorbitan esters selected from polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), polysorbate 85 (TWEEN85) and combinations thereof, and c) A second sorbitan ester selected from sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), and combinations thereof. A dental instrument cleansing composition containing, The present invention provides a dental instrument cleaning composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0018】 In one aspect, the present invention is a) Isopropyl fatty acid esters selected from isopropyl palmitate, isopropyl myristate, and combinations thereof, b) Polyoxyethylene sorbitan esters selected from polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), polysorbate 85 (TWEEN85), and combinations thereof. c) A second sorbitan ester selected from sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), and combinations thereof, and d) A solvent selected from propylene glycol, water, and mixtures thereof A dental instrument cleansing composition containing, The present invention provides a dental instrument cleaning composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0019】 In one aspect, the present invention is a) Isopropyl myristate, b) Polysorbate 80, and c) Sorbitan laurate A dental instrument cleansing composition containing, The present invention provides a dental instrument cleaning composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0020】 In one aspect, the present invention is a) Isopropyl myristate, b) Polysorbate 80, c) Sorbitan laurate, and d) A solvent selected from propylene glycol, water, and mixtures thereof A novel dental instrument cleansing composition comprising, This invention provides a novel dental instrument cleaning composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0021】 In one embodiment, the present invention provides a novel dental instrument cleaning composition as defined in any of the above embodiments, which does not contain alcohol, for example, a novel alcohol-free dental instrument cleaning composition. 【0022】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, wherein a fatty acid isopropyl ester is present in an amount of 2 to 70% w / w, preferably 5 to 65% w / w. In one embodiment, when the dental instrument cleansing composition does not contain water as a solvent, the fatty acid isopropyl ester is present in an amount of 10 to 65% w / w. In another embodiment, when the dental instrument cleansing composition contains water as a solvent, the fatty acid isopropyl ester is present in an amount of 3 to 15% w / w, preferably 5 to 7% w / w. 【0023】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, wherein polyoxyethylene sorbitan ester is present in an amount of 0.5 to 45% w / w, preferably 0.7 to 40% w / w. In one embodiment, when the dental instrument cleansing composition does not contain water as a solvent, polyoxyethylene sorbitan ester is present in an amount of 10 to 45% w / w, preferably 12 to 40% w / w. In another embodiment, when the dental instrument cleansing composition contains water as a solvent, polyoxyethylene sorbitan ester is present in an amount of 0.5 to 4% w / w, preferably 1 to 2% w / w. 【0024】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, wherein the second sorbitan ester is present in an amount of 0.5 to 65% w / w, preferably 0.7 to 60% w / w. In one embodiment, when the dental instrument cleansing composition does not contain water as a solvent, the second sorbitan ester is present in an amount of 10 to 65% w / w, preferably 12 to 60% w / w. In another embodiment, when the dental instrument cleansing composition contains water as a solvent, the second sorbitan ester is present in an amount of 0.5 to 4% w / w, preferably 1 to 2% w / w. 【0025】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, wherein the second sorbitan ester is not itself another polyoxyethylene sorbitan ester. 【0026】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, further comprising at least one solvent. Suitable solvents include water, propylene glycol, and combinations thereof. 【0027】 In a further embodiment, the dental instrument cleansing composition defined in any of the above embodiments contains at least one solvent in an amount of 0.2 to 95% w / w, preferably 0.7 to 90% w / w. 【0028】 In a further embodiment, the dental instrument cleansing composition defined in any of the above embodiments contains propylene glycol in an amount of 0.2 to 15% w / w, preferably 0.7 to 12% w / w. 【0029】 In a further embodiment, the dental instrument cleansing composition defined in any of the above embodiments contains water in an amount of 70 to 95% w / w, preferably 80 to 95% w / w, and more preferably 85 to 90% w / w. 【0030】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, further comprising at least one aroma oil or fragrance oil. Suitable aroma oils or fragrance oils for use in the present invention include, but are not limited to, spearmint, menthol, peppermint, and mixtures thereof. In a further embodiment, the dental instrument cleansing composition comprises at least one aroma oil or fragrance oil selected from spearmint, peppermint, and mixtures thereof. In a further embodiment, the dental instrument cleansing composition comprises spearmint oil and peppermint oil. In a further embodiment, the dental instrument cleansing composition comprises at least one aroma oil or fragrance oil in an amount of 0.1 to 2.0% w / w, preferably 0.2 to 1.0% w / w. 【0031】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the aforementioned embodiments, further comprising at least one preservative. In another embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the aforementioned embodiments, further comprising at least one preservative selected from potassium sorbate, sodium benzoate, phenoxyethanol, cetylpyridinium chloride, and combinations thereof. In a further embodiment, the dental instrument cleansing composition comprises at least one preservative selected from potassium sorbate, phenoxyethanol, and combinations thereof, preferably a combination of potassium sorbate and phenoxyethanol. In a further embodiment, the at least one preservative is present in an amount of 0.05 to 1.5% w / w, preferably 0.1 to 1.0% w / w, and more preferably 0.25 to 0.75% w / w. 【0032】 In one embodiment, the present invention provides a dental instrument cleaning composition as defined in any of the above embodiments, further comprising a sweetener selected from sodium saccharin, aspartame, sucralose, and stevia, preferably sodium saccharin. The sweetener is present in an amount of, for example, 0.05% w / w, depending on the taste. 【0033】 In one embodiment, the present invention provides a dental instrument cleansing composition as defined in any of the above embodiments, further comprising a pH adjusting agent, for example, citric acid, sodium hydroxide, or sodium citrate, preferably citric acid. The dental instrument cleansing composition may further contain a metal ion sequestering agent such as disodium EDTA. In one embodiment, the pH adjusting agent or metal ion sequestering agent is present at less than 1% w / w. 【0034】 In one embodiment, the present invention provides a dental instrument wipe impregnated with a cleansing composition as defined in any of the above embodiments. 【0035】 In one aspect, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) Second sorbitan ester A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0036】 In another embodiment, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) Second sorbitan ester A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain alcohol. 【0037】 In another embodiment, the present invention is a) Fatty acid isopropyl ester, b) Polyoxyethylene sorbitan ester, c) A second sorbitan ester, and d) A solvent selected from propylene glycol, water, and mixtures thereof. A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0038】 In one aspect, the present invention is a) Isopropyl fatty acid esters selected from isopropyl palmitate, isopropyl myristate, and combinations thereof, b) Polyoxyethylene sorbitan esters selected from polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), polysorbate 85 (TWEEN85) and combinations thereof, and c) A second sorbitan ester selected from sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), and combinations thereof. A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0039】 In one aspect, the present invention is a) Isopropyl fatty acid esters selected from isopropyl palmitate, isopropyl myristate, and combinations thereof, b) Polyoxyethylene sorbitan esters selected from polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), polysorbate 85 (TWEEN85) and combinations thereof, and c) A second sorbitan ester selected from sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), and combinations thereof, and d) A solvent selected from propylene glycol, water, and mixtures thereof A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0040】 In one aspect, the present invention is a) Isopropyl myristate, b) Polysorbate 80, and c) Sorbitan laurate A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0041】 In another embodiment, the present invention is a) Isopropyl myristate, b) Polysorbate 80, c) Sorbitan laurate, d) A solvent selected from propylene glycol, water, and mixtures thereof A dental instrument wipe impregnated with a cleansing composition containing, The present invention provides dental instrument wipes impregnated with a cleansing composition that does not contain methanol, ethanol, or isopropyl alcohol. 【0042】 In another embodiment, the present invention provides a dental instrument wipe impregnated with a cleansing composition as defined in any of the above embodiments, wherein the cleansing composition does not contain alcohol, for example, an alcohol-free cleansing composition. 【0043】 definition The terms “wash,” “cleansing,” or “wash” are used herein synonymously to mean the removal of food particles, dirt, pathogens / microorganisms and other oral residues by wiping and / or washing action, as well as the breath-freshening function of the formulations of the present invention. 【0044】 The term “dental appliance” as used herein means dentures or partial dentures, artificial teeth, removable orthodontic bridges and both upper and lower denture bases, orthodontic fixation devices and appliances, protective mouthguards, night guards for preventing teeth grinding and / or temporomandibular joint (TMJ) disorders, etc. 【0045】 In this specification, the term "dental instrument cleanser" means a preparation for use outside the mouth to clean dental instruments. 【0046】 The term "microemulsion" as used herein means a clear, thermodynamically stable, isotropic liquid mixture of oil and surfactant in combination with an auxiliary surfactant. Microemulsions may be water-free or in a diluted form. Once diluted, microemulsions have uniform submicron-sized particles. 【0047】 The term "wipe" as used herein means woven and nonwoven substrates, as well as sponges, and insoluble substrates including, for example, cellulose substrates. Nonwoven substrates are preferred. Nonwoven means that the layer is composed of fibers that are not woven into a fabric but are bonded together by mechanical, thermal, or chemical entanglement, forming a sheet or mesh structure. The insoluble substrate is preferably a viscose polyester blend, a viscose polypropylene blend, or a viscose polyester polypropylene blend, more preferably a viscose polypropylene blend, and even more preferably a 65% viscose-35% polypropylene blend. Insoluble substrates can be obtained from a wide variety of commercially available materials. A preferred wipe according to the present invention is a wipe sold by NOVONETTE® Thermal Bond, Suominen. The insoluble substrate is not limited to any form, specific pattern, design, or shape. It may be flat, patterned, or embossed, and may be any size or shape. The wipe of the present invention is preferably 11 cm × 15 cm or 15 cm × 20 cm. The insoluble substrate must not be torn or disintegrated, and should be disposed of or discarded after a single use. 【0048】 In this specification, the term "wet wipe" refers to an insoluble substrate to which the dental instrument cleansing composition according to the present invention is added in and on. When added, the wet wipe contains a sufficient amount of the cleansing composition to wet, moisten, and soak. That is, the addition rate to the wipe is at least 2.0 grams of the cleansing composition per gram of dry substrate. 【0049】 The term "fatty acid isopropyl ester" as used herein means an ester of isopropanol with a suitable fatty acid such as myristic acid or palmitic acid. Isopropyl myristate is an ester of isopropanol with myristic acid (tetradecanoic acid) and is also known as propan-2-yltetradecanoate, tetradecanoate 1-methylethyl, or isopropyl myristate. Isopropyl palmitate is an ester of isopropanol with palmitic acid (hexadecanoic acid) and is also known as propan-2-ylhexadecanoate, isopropylhexadecanoate, hexadecanoate isopropyl, or hexadecanoate 1-methylethyl. 【0050】 Examples of polyoxyethylene sorbitan esters according to the present invention include polysorbate 20 (TWEEN20), polysorbate 21 (TWEEN21), polysorbate 40 (TWEEN40), polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), and polysorbate Polysorbate 85 (TWEEN85) and combinations thereof, preferably selected from the group consisting of polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), polysorbate 85 (TWEEN85) and combinations thereof, more preferably polysorbate 80. 【0051】 Examples of the second sorbitan ester according to the present invention include sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan tristearate (SPAN65), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), sorbitan oleate (SPAN80), sorbitan sesquioleate (SPAN83), sorbitan trioleate (SPAN85), sorbitan isostearate (SPAN120), and combinations thereof, preferably selected from the group consisting of sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), and combinations thereof, and more preferably sorbitan monolaurate (SPAN20). 【0052】 Preferably, the present invention is b) Polyoxyethylene sorbitan esters are selected from polysorbate 60 (TWEEN60), polysorbate 65 (TWEEN65), polysorbate 80 (also known as polyoxyethylene (20) monooleate sorbitan or TWEEN80), polysorbate 81 (TWEEN81), polysorbate 85 (TWEEN85) and combinations thereof, and c) The second sorbitan ester is selected from sorbitan monostearate (also known as sorbitan stearate or SPAN60), sorbitan monolaurate (SPAN20), sorbitan palmitate (SPAN40), and combinations thereof, or b) The polyoxyethylene sorbitan ester is selected from polysorbate 20 (TWEEN20), polysorbate 21 (TWEEN21), polysorbate 40 (TWEEN40), and combinations thereof; c) The second sorbitan ester is selected from sorbitan oleate (SPAN80), sorbitan sesquioleate (SPAN83), sorbitan trioleate (SPAN85), sorbitan isostearate (SPAN120), and combinations thereof. The present invention provides a dental instrument cleansing composition or a dental instrument wipe impregnated with a cleansing composition as defined in any of the above embodiments. 【0053】 wipe The wet wipes according to the present invention are prepared by wetting the dry substrate with at least 1 gram of the composition per gram of dry substrate. Preferably, the dry substrate is wetted with at least 2.0 grams, more preferably at least 3.0 grams, and even more preferably at least 2.7 grams or 3.5 grams of the composition per gram of dry substrate. 【0054】 The wipes according to the present invention may be packaged individually as single wipes or as multi-packs. When the wipes are packaged as single wipes, each wipe may be packaged in an individual pouch, and several such pouches may be placed in a box, for example, 1, 14, 15, 20, 28, 30, or 40 pouches in a box. When the wipes are packaged as multi-packs, some wipes (for example, 20, 25, 30, 40, 50, or 70) may be packaged in a resealable container, such as a pack or container that can be resealed using an adhesive label or a plastic lid. 【0055】 The packaging contents of the wet wipes according to the present invention must protect the product from loss of fragrance and / or solvent. They must not interact with the product to produce adverse effects on either the cleansing composition or the properties of the packaging. The packaging of the wet wipes according to the present invention may be in any suitable form. Preferably, the packaging contents may include an aluminum barrier lamination and a tightly sealing cap. The packaging may be in any suitable size and shape, and preferably should be small and easily portable. [Examples] 【0056】 experiment The following examples of compositions according to the present invention are illustrative only and do not limit the scope of the invention. Various changes and modifications to the disclosed embodiments will be obvious to those skilled in the art, and such changes and modifications may be made as long as they do not depart from the spirit of the invention and the scope of the appended claims. 【0057】 Manufacturing method The compositions according to the present invention can be prepared by mixing the components in appropriate relative amounts in any convenient order (see the examples below). Preferably, the oil layer and the water layer are formed separately and then the two layers are combined. 【0058】 The wet wipes according to the present invention can be prepared by preparing a dry, insoluble substrate of appropriate size, and then contacting the substrate with a cleansing composition, for example, by spray dispersion. Once prepared, the wet wipes are transferred to an airtight, resealable container of appropriate size and then sealed. 【0059】 Examples 1 to 3 illustrate cleansing compositions of the present invention that do not contain water. 【0060】 [Table 1] 【0061】 Examples 4 to 8 illustrate the cleansing compositions of the present invention that contain propylene glycol and water. 【0062】 [Table 2] 【0063】 Reference Example A 【0064】 [Table 3] 【0065】 Reference example A is a typical alcohol-free mouthwash preparation. 【0066】 Test data Biofilm formation on the acrylic surface of dentures most frequently occurs when the denture cleaning regimen is not followed properly. Colonizing biofilm cells, particularly those of the fungus Candida, are considered a major cause of Candida-associated denture stomatitis. This infection occurs in over 65% of denture wearers. Clinically, it is observed as an erythematous area on the palate that comes into contact with the denture mounting surface. 【0067】 Clearly, strict adherence to an appropriate denture cleansing regimen is key to preventing Candida-related denture stomatitis. Generally, such a cleansing plan involves immersing the dentures in an appropriate cleanser. Furthermore, the denture surface can be brushed using a toothbrush with a dedicated toothpaste or gel. 【0068】 The objective of this study is to use an in vitro approach to evaluate the efficiency of dental wipes impregnated with the compositions of Example 6 and Example 8 in removing microorganisms from acrylic denture bases. 【0069】 Materials and methods Formation of microbial biofilms on acrylic surfaces Pre-adjusted denture acrylic square (1cm) by immersing in sterilized artificial saliva at 37°C for 24 hours. 2 The acrylic samples were immersed in a prepared and standardized microbial inoculum at 37°C for 72 hours. After incubation, the contaminated acrylic samples were immersed in sterile water for 5 minutes to remove loosely bound / floating microorganisms. 【0070】 Microbial removal using cleansing wipes To implement a standardized "wiping" procedure, cleansing wipes were attached to the surface of a dental material polishing machine. This instrument had a rotating turntable that could be operated at speeds between 50 and 600 revs / min. The diameter of the turntable was 300 mm, thus ideally accommodating large or small specimens. In this study, the cleansing wipes were placed on the surface of the rotating turntable so as to rotate with the turntable's movement. A stationary arm bearing a load was mounted on the turntable, holding an acrylic square in a fixed position in direct contact with the cleansing wipes. Variations in the degree of wiping were achieved by maintaining a constant rotation and varying the time. In this study, the ability of the cleansing wipes to remove microbial colonization was evaluated by wiping for 60 seconds and / or 10 seconds at 100 revs / min, or by rinsing with warm water in a standardized flow. The control was an acrylic surface that had never been exposed to the wiping method. 【0071】 After wiping, microorganisms on the acrylic surface were fixed in 4% (v / v) formalin for 24 hours. Images stained with propidium iodide from each test group were examined using a confocal laser scanning microscope (CLSM). The images were converted to black and white binary, and the range percentage was determined using ImageJ software (Rasband, WS, ImageJ, US National Institutes of Health, Bethesda, Maryland, USA, http: / / imagej.nih.gov / ij / , 1997-2014). Quantitative data analysis was performed using SPSS Statistics (v20) (IBM). To compare colony formation areas between treatment groups, composite analyses were performed using the Kruskal-Wallis test and the Mann-Whitney-Wilcoxon test. Significant differences were determined at the 0.05 level. 【0072】 The two studies were conducted using different treatments. 【0073】 Research 1 The following samples were evaluated. 1. Not wiped off 2. Wipe with reference example A for 10 seconds. 3. Wipe with reference example A for 60 seconds. 4. Wipe for 10 seconds in Example 6. 5. Wipe with the solution from Example 6 for 60 seconds. 【0074】 result Table 1 shows the quantitative results of acrylic colony formation, assessed for 15 fields of view (five from each of three replicated acrylic specimens). 【0075】 [Table 4] 【0076】 The Shapiro-Wilk test showed that the data were not normally distributed (P<0.0001). ANOVA revealed a significant difference in the level of colonization among the test groups (P=0.02). Using the Turkey-Posthoc test in one-way ANOVA, it was shown that compared to the unwiped control, there was a significant reduction in remaining colonization with 60-second wiping by Comparative Example A (P=0.012), 10-second wiping by Example 6 (P=0.037), and 60-second wiping by Example 6 (P=0.002). There was no evidence of a significant reduction between the unwiped control and 10-second wiping by Reference Example A (P=0.304). 【0077】 conclusion It was clear that wiping the denture acrylic surface with both the wipes from Comparative Example A and Example 6 for 60 seconds resulted in significant removal of microorganisms compared to the unwiped control. Furthermore, a significant reduction in microbial removal was also determined by using the wipe from Example 6 for 10 seconds. 【0078】 This removal study demonstrates that the physical action of wiping denture acrylic with a wipe impregnated with the composition according to the present invention for 10 seconds results in improved removal compared to a wipe impregnated with a typical mouthwash solution. 【0079】 Research 2 The following samples were evaluated. 1. Not wiped off 2. Rinse with water for 10 seconds. 3. Wipe for 10 seconds as in Example 8. 【0080】 result Table 2 shows the quantitative results of acrylic colony formation, assessed for 150 fields of view (five from each of 30 replicated acrylic specimens). 【0081】 [Table 5] 【0082】 The Shapiro-Wilk test showed that the data were not normally distributed (P<0.0001). The Kruskal-Wallis test on independent samples showed a significant difference in colony formation between the test groups (P<0.0001). The Mann-Whitney-Wilcoxon test, comparing unwiped controls with washed samples, revealed a significant reduction in residual colony formation with 10-second wiping (P<0.0001) and 10-second rinsing with running water (P=0.018) as in Example 8. The significant reduction in colony formation was also evident in the wiped samples compared to the rinsed samples (P=0.013). 【0083】 conclusion This study revealed that wiping acrylic contaminated with microorganisms for 10 seconds using Example 8 resulted in significant removal of microorganisms compared to both the unwiped control and the sample rinsed with water. The present invention encompasses the following embodiments. (Embodiment 1) a. Fatty acid isopropyl ester, b. Polyoxyethylene sorbitan ester, c. Second sorbitan ester A dental instrument cleansing composition comprising, A dental instrument cleaning composition that does not contain methanol, ethanol, or isopropyl alcohol. (Embodiment 2) The dental instrument cleansing composition according to Embodiment 1, wherein the fatty acid ester isopropyl ester is selected from isopropyl palmitate, isopropyl myristate, and combinations thereof. (Embodiment 3) A dental instrument cleansing composition according to Embodiment 1 or 2, wherein the polyoxyethylene sorbitan ester is selected from polysorbate 20, polysorbate 21, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 81, polysorbate 85, and combinations thereof. (Embodiment 4) A dental instrument cleansing composition according to any one of Embodiments 1 to 3, wherein the second sorbitan ester is selected from sorbitan monostearate, sorbitan tristearate, sorbitan monolaurate, sorbitan palmitate, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan isostearate, and combinations thereof. (Embodiment 5) A dental instrument cleansing composition according to any one of Embodiments 1 to 4, wherein the composition further comprises a solvent selected from propylene glycol, water, and mixtures thereof. (Embodiment 6) A dental instrument cleansing composition according to any one of Embodiments 1 to 5, wherein, when the cleansing composition does not contain water as a solvent, a fatty acid isopropyl ester is present in an amount of 10 to 65% w / w. (Embodiment 7) The dental instrument cleansing composition according to any one of Embodiments 1 to 6, wherein, when the cleansing composition contains water as a solvent, fatty acid isopropyl ester is present in an amount of 3 to 15% w / w. (Embodiment 8) A dental instrument cleansing composition according to any one of Embodiments 1 to 7, wherein, when the cleansing composition does not contain water as a solvent, polyoxyethylene sorbitan ester is present in an amount of 10 to 45% w / w. (Embodiment 9) A dental instrument cleansing composition according to any one of Embodiments 1 to 8, wherein, when the cleansing composition contains water as a solvent, polyoxyethylene sorbitan ester is present in an amount of 0.5 to 4% w / w. (Embodiment 10) The dental instrument cleansing composition according to any one of Embodiments 1 to 9, wherein, when the cleansing composition does not contain water as a solvent, a second sorbitan ester is present in an amount of 10 to 65% w / w. (Embodiment 11) A dental instrument cleansing composition according to any one of Embodiments 1 to 10, wherein, when the cleansing composition contains water as a solvent, a second sorbitan ester is present in an amount of 0.5 to 4% w / w. (Embodiment 12) A dental instrument cleansing composition according to any one of Embodiments 1 to 11, further comprising at least one preservative selected from potassium sorbate, sodium benzoate, phenoxyethanol, cetylpyridinium chloride, and combinations thereof. (Embodiment 13) A dental instrument cleansing wipe impregnated with the composition described in any one of Embodiments 1 to 12. (Embodiment 14) Use of a dental instrument cleansing composition according to any one of Embodiments 1 to 12 or a dental instrument cleansing wipe according to Embodiment 13 for cleaning dental instruments. (Embodiment 15) Use of a dental instrument cleansing composition according to any one of Embodiments 1 to 12 or a dental instrument cleansing wipe according to Embodiment 13 for cleaning dentures.

Claims

[Claim 1] a. Fatty acid isopropyl esters in amounts of 3 to 15% w / w, selected from isopropyl palmitate, isopropyl myristate, and combinations thereof. b. Polyoxyethylene sorbitan ester in an amount of 0.5 to 4% w / w, and c. A second sorbitan ester selected from sorbitan monostearate, sorbitan monolaurate, sorbitan palmitate, and combinations thereof, in an amount of 0.5 to 4% w / w. A dental instrument cleansing composition comprising, A dental instrument cleaning composition comprising 0.7 to 12% w / w propylene glycol and 85 to 90% w / w water, and free from methanol, ethanol, and isopropyl alcohol. [Claim 2] The dental instrument cleansing composition according to claim 1, wherein the polyoxyethylene sorbitan ester is selected from polysorbate 20, polysorbate 21, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 81, polysorbate 85, and combinations thereof. [Claim 3] The dental instrument cleansing composition according to claim 1 or 2, further comprising at least one preservative selected from potassium sorbate, sodium benzoate, phenoxyethanol, cetylpyridinium chloride, and combinations thereof. [Claim 4] A dental instrument cleansing wipe impregnated with the composition according to any one of claims 1 to 3. [Claim 5] Use of the dental instrument cleansing composition according to any one of claims 1 to 3 for cleaning dental instruments. [Claim 6] Use of the dental instrument cleansing wipe according to claim 4 for cleaning dental instruments. [Claim 7] Use of the dental instrument cleansing composition according to any one of claims 1 to 3 for cleaning dentures. [Claim 8] Use of the dental instrument cleansing wipe according to claim 4 for cleaning dentures.

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