A method for electrochemical synthesis of 1h-indazole, 1h-indazole n-oxide and their derivatives
A novel electrochemical synthesis using a Zn or Pb cathode and RVC anode in a methanol-acetonitrile solvent system addresses the challenges of regioselective functionalization in 1H-indazole synthesis, achieving high-yield derivatives with functional groups at the C3 position without toxic precursors.
Patent Information
- Authority / Receiving Office
- KR · KR
- Patent Type
- Patents
- Current Assignee / Owner
- PUSAN NAT UNIV IND UNIV COOPERATION FOUND
- Filing Date
- 2024-04-17
- Publication Date
- 2026-07-21
AI Technical Summary
Conventional methods for synthesizing 1H-indazole and 1H-indazole N-oxide face challenges in regioselective functionalization at the C3 position due to low reactivity and reigoselectivity, and existing electrochemical methods require toxic hydrazine or azide precursors.
A novel electrochemical synthesis method using a Zn or Pb cathode and RVC anode in a mixed solvent of methanol and acetonitrile with potassium acetate, allowing for the electrolysis of oximes to regioselectively introduce functional groups like carbon, oxygen, and sulfur at the C3 position of 1H-indazole derivatives.
The method enables high-yield synthesis of 1H-indazole and 1H-indazole N-oxide derivatives, facilitating the introduction of functional groups at the C3 position, overcoming the limitations of conventional methods and avoiding the use of toxic precursors.
Smart Images
Figure R1020240051627_ABST