6,7-Dihydro-5H-benzo[7]annulene derivatives, methods of production thereof, pharmaceutical preparations containing them, and use thereof for the production of medicinal products

Abstract

The invention relates to Compound of general formula (I),R1, R2, R3 and R4 independently of one another stand for hydrogen or fluorine, wherein at least one substituent selected from R1, R2, R3 and R4 stands for fluorine, R5, R6 and R7 independently of one another stand for hydrogen, fluorine, chlorine, bromine, methyl, ethyl, trifluoromethyl or nitrile X is selected from the group comprising H, C^Cg-alkyl·, C3-C8-cycloaikyl-, C2-C6-alkenyl, C2-C6-a)kynyl, C-(-Cg~alkyl-S(O)2-, C-|-Cgalkylcarbonyl-, phenyl-C2-C8-alkyl-, which optionally can be substituted once, twice or multiply with - OH, halogen, -CN, -NR8R9, C(O)NR10R11- N(R10)C(O)NR10R11, -CrC6haloalkpxy, -Cτ -C6-alkoxy, -C(Ο)OH, CpOOCCpCg-alkyl or -C(O)OBenzyl, and optionally * hydrogen atoms can also be replaced with deuterium atoms, R8 and R9 stand for CrC6-alkyl, C3-C7- cycloalkyl, phenyl or benzyl, optionally substituted with halogen rr deuterium, R10 and R11 stand for hydrogen or CrC&-alkyl, C3-C7-cycloalkyl, phenyl or benzyl optionally substituted with halogen or deuterium, Y stands for a per- or partially-fluorinated CpC^alkyl or per- or partially-fluorinated C3C8-cycloalkyl, m stands for 4, 5, 6 or 7, n stands for 2, 3, 4, 5 or 6, p stands for 0, 1 or 2, q stands for 0, 1, 2, 3, 4, 5 or 6