Anti-SLC3a2-APIS antigen-binding proteins and methods of use thereof

Abstract

The present disclosure provides monospecific antigen-binding proteins that bind humanSLC3A2-APISand bispecific antigen-binding proteins that bind toSLC3A2-APISand CD3 (SLC3A2-APISxCD3). In certain embodiments, the disclosed bispecific antigen-binding proteins include a first antigen-binding domain that bindsSLC3A2-APISand a second antigen-binding domain that binds CD3. In some embodiments, the disclosed antigen-binding proteins inhibit tumor growth. In some embodiments, the disclosed antigen-binding proteins ameliorate one or more symptoms of a myelodysplastic syndrome.