Systems and methods for real world evidence database data integration

Abstract

An integrated data repository may be generated that includes genomics information and health information for a common group of individuals. A data processing pipeline may be implemented with respect to information stored by the integrated data repository. The data processing pipeline may include a number of sets of data processing instructions that are executable to analyze specified information stored by the integrated data repository and generate different datasets. The datasets may be analyzed to determine an impact of characteristics of individuals and / or an amount of impact of treatments provided to individuals in which a biological condition is present.

Description

[0001]ttorneoceto. ,s aecaeoenm cearmsroro rovsonaaen caonerao. , eee , ,o rovsonaaen caonerao. , mer, ,o rovsonaaen caonerao. reerenceereenneeemr enerre,.,e enre conens o wc are eacncororae arcecmuremenaons oeresenscosure reaeeneraoee o comuer anerae, an morearcuaro a comuer arcecureoreneran aaa reosor anenomcess maua.e sources oeacareaancuneacarensurance camsaa varousnvuas vseacareroversorea one or moreooca conons, roucseese oaoccaumenaon maeenerae.or exame, meca recors mae rover,aoraorereroversancue cnca oservaons recore aeacarenormaon, one or ms resus,anoscesnormaon,mannormaon,enaea eeneraeanocraee comamnaenonnsoereo, anee. ona,n recors ma servcesroveonvuas earmacaroen wrov reseco aeas one oroucs ornormaon maeeneraeancaesnormears.onurer,eansurance cams comanes reaeoereamen onvuas w rese ocaone one or meaonsurance conons. reooca ncune escercreoncer meencsa a r meceoros onc auunra: o oannnvnuoarmsa reonrevronm, aora oan ree oors moorre ttorneoceto.: coemuuran s osenm,v au naums,eara o soreene ars m.oencu oarera eam reoosmoenrs, aneneran, e mon anneraeaa reosorncun: sorn aeas aorone meoncues oe meca recors oe one or moreura onvuas an aea oenormaon numer oeners.n oer emomens,e meoncueseners aoron oencun aura orsoensenerae usn arsasuncon, wearenn aaae oeura orsoens corresono one or more oeura o one or more a moecuaraa reosor senneaaeo aeacareaa mannvuas sore oann,romeeaaa manaemen ssem,n resonseoeaemen ssem corresonno one or more oeura onvuas aneneranaae,eaaa eners usn a seconasuncon,or one or moreoe , a numer oea corresonn ns oeura orsoens n o one or more oeura onvuas. oaner oomer a emeomens,e meoncues anazn aona normaon moreoronsas one aonaaa reosor, oonancuneermnn one or emomens, oe a meoonanncourmesaoenerom renmnove aorsro seuc oe a caoarursoc oessnnormnasrounc.onn osoer rocessne sore aeasoron o r r enormaon execuners se oaanocessnnsruconso anazeersaa seoeermne aoron o aura o ovuasn wc aooca cononsresen aneneran arsaaseore one emr moorem oeneura onvuasn wceooca cononsresen.n oernsruconsso,rero mceessonnceu soersee aermeansnor onoen o or moeren aormaonoan se ex oecuanaroec oenssen more aona se oaarocessnnsruconso anaze one or more or eermne aoron o aura onvuasn wc aooca con aononsar se oaa eneran one or more aona se oaaore one or more oeu esen ann wceooca cononsresen.n oer emomens,rea me oonnvcuas eermnn one or moreenomc muaonsresenne one or more uesnvuas.n oer emomens,e meoncueseermnn au orae ourrea o oonsrove ora caneroveo one or more oeura onvuas.amen emomens,e meoncueseermnn survva raesore one or mn oer ureason oencen ov suurvasv.a rnae oeewree enm aorem ore oe corr aemnesn, oee meuoranc oureesameenesrm annn a ttorneoceto.:necnoumesc meueramonnn o eec oance o or mroeraemeennomorc meuaron ssu.sn oer emomens,e meo oer emomens,e meoncues arrannenee oraeerou onvuas.n ura oaaaes an aura oocanseweeneauraa reo osoara waes a werennvuaocans oeura ooc , aa ansncan one or more rows o aaoae oeura oaaaesa corresono one or more aona rows o an urana oaaaaaaees onceura oaaaes.n oer emomens,e meoe aaaea sore ue one or moreaaaes seeceromerou conssn o: ao one or moresenomcsaa oeura onvuas aaaa soresaa reae a soresnoaen vssnvuaso one or moreeacarerovers aaaae reasaecaoe one orr mmoareona coenrre vssonson oneo or re msoerecveae secravrecesrovroversencoaenvuea ssec wo s aoreasanaormeaoan s reoraeseeors aonaean naea onrmsuaranocne o comeanur oarov oernnmevnaua ens aaa maeamenor servcesroveoe anorma ura onvuas aaaae sornnvuon corresonnoeansurance coveraenormaonoreura o oaas an aaaaea soresnormaon reaeoarmaceucareamens one onre moerou onvuas.n oer emomens,e meoncues sorne encaroen oaaera srouncsureesorne, anurnner,m aenaore aaera m reoosonreernoermrane onaea or re moosreoe- n oer emomens,e moecuaraa reosor sores aeas one or mo r.normaon, eenomcnormaon,enecnormaon, eenere oenomc meaoomcnormaon,ranscromcnormaon,ramen cnormaon, receornormaon, meaonnormaon, orr omcnormaon,mmune meca re scosrems onc aunura oa onnnnvorumaaso rnerrooemeo vn amc ,aoan r roerm onoesa ooo rrn. mncun eecroncnvuas,aa sore a moecuaraa reosor anenerano,reeeura o ssem, a numer oeners.n oer emomens,e ssemncues m comunneraeaa reosorncun: sorn aeas aoron oenormaon ooen an recors oe one or moreura onvuas an aeas aoron oe num meca eunraers o.nrs ooere enmsoenemraenes, usen s asemrsnacsueusnceonner,a wnere ana onae ore mnocreue onr o ae ttorneoceto.: muoreacuar oaras reooesnso crorr seesnonno oenea oar moereo o aeeaurcaare oaan mavuas sore a oann,romeeaaa manaemen ssem,n resonseoenaemen ssem corresonno one or more oeura onvuas aneneran,aae,eaaa eners usn a seconasuncon,or one or moreoens a numer oea corresonno one or more oeura onvuas.n o oereura orsoensncues anazn aonanormaon oanerom aeas o emomens,e ssem oonancuneermnn one or moreorons o aonne aonaaa reosor, rouce a corus onormaon.n oer emomen anormaono removeo se oaarocessnnsruconsorroce s,e ssemncueseermnn ars execuners se oaarocessnssne sore aeasoron oenormaon aoron o aura onvuasn wnscruconso anazeersaa seoeermne arsaaseore one or more oe auooca cononsresen aneneran cononsresen.n oer emomens,rea ss oemnncvuasn wceooca aona se oaarocessnnsruconsorro ueseermnn one or morenormaon execune one or more aonacessne sore aeasoron oe one or more aona se oaaee se oaarocessnnsruconso anaze ooca cononsresen anenremranen aoron o aura onvuasn wc a more oeura onvuasn wc onee or moore aona se oaaore one or emomens,e ssemncueseermnn one ooca cononsresen.n oer one or more oeura onvuas.n or moreenomc muaonsresenne eermnn aura oreamen oonsrove oerr emomens,e ssemncues eura onvuas.n oer emomens,e sas caneroveo one or more o raesore one or more oeura onvuas.emncueseermnn survvancueseermnn corresonence o survv n oer emomens,e ssemreamens an aenomc muaon oea on reaeeween areamen oeura o emomens,e ssemncueseermnn or moreenomc muaons.n oer rou onvuas.n oer emomens,e e sscaec oreamenorer suse oe reosor w aura oaaaes an auram oncuoecs arranneneraeaa oaaaes, werennvuaocans oeura oaoncsaenwesennceaura or more rows o aaaae oeura oaaaesa corresono one onr one aona rows o an aonaaaae oeura oaaaes.n oer emom menorse, ttorneoceto.: oe: auaraaa oeaaa saoreessenncoumecs onea oar o moreeauaraae os senecveuarosm aaearoua conssn reaeo one or moreaen vssnvuaso one or moreeacare soresaaaea soresnormaon corresonno resecve servces rovers aaa reseco one or moreaen vsso one or moreeacare roveonvuas w aaae aaaaea soresersonanormaon oerovurersncae e seconaea soresnormaon reaeo aeansurance coman oar onvuas aaa maeamenor servcesroveoeura onvuasov aernmaeanaa een anormaon corresonnoeansurance coveraenormaonor sornnvuas an aaaaea soresnormaon reaeoarmaceuceaureraam o oa onre moreeaar souruc ourensnv anuans.ernm oeaere em ens one aao remoesnso,re sersoermmnnc ounees or s moronre encaon oeraonseore,urn, anor aer moneneraeaa reoseoe- n oer emomens,e ssemncues a moecuaraa reosor sores aea r. more oenomcnormaon, eenomcnormaon,enecnormaos one ornormaon, meaoomcnormaon,ranscromcnormaon,nr, eenecnormaon,mmune receornormaon, meaonnormaon, amenomc escreerens one or more non-ransor com orroeomcnormaon. sorn comuer-execuaensruconsoeror uer-reaae sorae meanormaonrom aaa reosorncun eecronmc m oeraonsncun: oannnvuas rerevn,or one or moreeura onveuacsa recors o aura o aa reosor aneneran, e comun ssem, a num,eaa sore a moecuar emomens,e one or more non-ransor comuer-r r oeners.n oerneraeaa reosorncun: sorn aeas aoreaonae meancues mon an recors oe one or moreura onvuas an a oease anormaon oe meca eners.n oer emomens,e one or more non-rans oron oe numer oncueseneran aaaencun aura orsoenosre comuer-reaae mea uncon, weren one or more oeura orsoens cornerae usn arsas ura onvuas sore a moecuaraa reosorres seono one or more oe eacareaa manaemen ssem oann,romeeaaan mnanaeemeaaeo a resonseoeaae,eaaa corresonno one or more oen sursaem,nnvuas aneneran, a numer oeaeners usn a seconasuncon, oor ttorneoceto.: o onen orv moureaso.enn os oer eemouramen os,res onoee onrs m coorrere nsono-nrno one or more oeurancues anazn aonanormaon oaneromansor comuer-reaae mea oonancuneermnn one or moreorons aeas one aonaaa reosor, rouce a corus onormaon.n oer emom o aonanormaono removeo comuer-reaae meancueseerm ens,e one or more non-ransor rocessne sore aeasoron onn ars se oaarocessnnsruconsor rocessnnsruconso anazeersaean sormaon execuners se oaanvuasn wc aooca cononsreseen aoneeernmene aoron o aura o or more oeura onvuasn wceoocara conn aornssaraseore one emomens,e one or more non-ransor comuer-reaa esen.n oer one or more aona se oaarocessnnsruconsoe meancueseermnn oron oenormaon execune one or more arorocessne sore aeasnsruconso anaze one or more aona se oaaeena se oaarocessnnvuasn wc aooca cononsresen anenrmeranen a ooron o aura o se oaaore one or more oeura onvuasn wcnee ooro mocrea a conasresen.n oer emomens,e one or more non-ransor comue ononncueseermnn one or moreenomc muaonsresenne r-reaae mea onvuas.n oer emomens,e one or more non-r one or more oeurancueseermnn aura oreamen oonsrovansor comuer-reaae mea or more oeura onvuasn oer emomenes, ore ona caneroveo one comuer-reaae meancueseermnn survv e or more non-ransor ura onvuas.n oer emomens,e onae o rare msore one or more oe reaae meancueseermnn corresonen ore non-ransor comuer- eura oreamens an aenomc muace o survva raeeween areamen o oer emomens,e one or more non oe one or moreenomc muaons.n eermnn ecac oreamenoron-ransor comuer-reaae meancues emomens,e one or more non-ranseor suse oerou onvuas.n oerneraeaa reosor w aura ora comuer-reaae meancues arranne eura oaaaes, werennvuaaoaceas ann as ourae oocanseweenncan one or more rows o aaaae oeura oaaaesuraa co orrocans or more aona rows o an aonaaaae oeura oaaaeseso.nno o oneer ttorneoceto.: emrouo cmonesnss,ne o: auraaaa oeaaa saoreessnecnoumec osnea oar o moreeaaaes seecerome a soresaa reaeo one or moreaen vssnvuausra onvuas aaa rovers aaaaea soresnormaon corre o one or moreeacarenvuas w reseco one or more sonno resecve servcesroveoncae e seconaaae aaaaen vsso one or moreeacarerovers onvuas aaaaea soresnaoea soresersonanormaon oeura overnmena en a maeam rmaon reaeo aeansurance coman or aaae sornnormaon corenor servcesroveoeura onvuas a ura onvuas an resonnoeansurance coveraenormaonorereamens oane er aaaaea soresnormaon reaeoarmaceucaransor comu ou onvuas.n oer emomens,e one or more non-nermeaeaae rre-reoasaore meeroarmncnu oense s oorrn moree oe-nee onr mcoareona oa serraucounrseseno an urn, anor aer moneneraeaa reosor.n oer emomens,ree, mnooermcuaaron,aae reneoscorno sromreaso an,ea es oennee ocr monreor omaeonno,m mcenaoormoaon, eenomcranscromcnormaon,ramenomcnormaon,mm mcnormaon, meaonnormaon, orroeomcnormaon une receornormaon, escreerens a meoncuneec. rom n,n a samencunonuceoes amn as seurnec,o aee sause ocne a ceannececr vraeraamne.n.nn o oeerr e emmoommeennss,, aem mnesoernncues suec a cancerreamenncues seecn areamenase oneeec oe oneenec varan.n oer emomens,e suecas cance on oe aeas cancers coanocarcnoma.n oer emome r.n oer emomens,e o: , uson,-, ,ns,e amenecc vaaroann ancues one or more oer emomens,e cancers cooreca cancer.n oe nor uson.nncues one or more o:, , , , anorr emo.mnens,enec varans e cancersrosae cancer.n oer emomens,en oer emomens, ,, , ,, , an e,c varansncues one or more o: , , , anor . , , , , suec unescerroenereerans, w a mereenoen mcounnor:n monncuorens,e aec onne ore mroerseencmee oo anes,as a ttorneoceto.: onee meonneocr vnarannc aunes a mmonnsoerrnnoe se suec a cancerreamen.n oer emomens, emomens,e samencues ceureec a aura o erenmes.n oer coanocarcnoma.n oer emome .n oer emomens,e cancers o: , uson,-, ens,,een aemc vacraanncues one or more oer emomens,e cancers cooreca cancer on anor uson.nncues one or more o:, , , .,n oer emomens,enec varans e cancersrosae cancer.n oer emo anor .n oer emomens, ,, , ,, , anmens,ene,c varan,sncu,es one or, more o: , ura osc sr, eseeenree, ranns a a me a , e n uraoo,rn ocu. onen or meoercen me mrecsoar eoancn o aeeas one o a ses anrocessne one or more mercso caracerze a sa ura o emomens,e one or more mercs are oanerom me.n varous eura o ses.n varous emomens,e meo mneaon casrom eac o varous emomens,e meoncuesavn oacues oann a same.n emomens,e casscaon moesrane usn c ne a same.n varous e meoncuesrannncues rann usern.n varous emomens, seece usnase on rann. .n varous emomens,e reons are ase on sncance ano n varous emomens,e meoncues rann emomens,e casscaro wne msor eac oeura o ses.n varous emomens,e meonc oesrane usn cross-vaaon.n varous vaaon.n varous emues usn,,,,,,,,,-o or more cross- ura o sesncueomens, aura o one or more mercsor eac oe mxure moe.n vs anear reresson,ernouroa sruon anor a ncuesncues caarcuouas enmoemreonas,e o one ourm moror meo meecrucessoa cseara ocne arnze am ao suamne ncuue a cusno omnea onre m.oren o varoeus eumraom oen sse o n ,s.en me varoousn ecmuoes cmuesnosm,aen ses conuren ann scoane.n varous emomens,e cusomane es ascaane.n oer emomens,e meoncues amnserns conuren cancerreamen.n oer emomens, amnsernoe su oe suec ancues seecn areamenase oneeecon. ec a cancerreamen ttorneoceto.: ancueusre muuseraes an exame arcecureoenerae anneraeaa reosor ureusraeess a on exeaamcaereraamae,w aocrcor conrresoo onne or morememenaons.aesn anneraeaa reoso no an arranemen oaa ureusra r, accorno one or morememenaons. rereverom aaa reeoss anor arcaecnuereraoeseneerae one or moreaasesromnormaon accorno on a reaeaarom a numer o sources, uree ours mroareesm an aercmenecauorns. e-eneeansurance camsaea aonenee-raeen anneeeranoemcasaa rea,o asccorancues morememe orno one or onaa sourrenauosnsra.es arameworoenerae aaase, aaaene ssem,ase ueres an a snceemraaecaaar raemo oso anr a,r acccorno one or morememenaons.no annera ecureoncororae meca recorsaa reosoruraee sosre aaa sa re eaaosonwor. suraancream ca om asna exaa amneenroomcescssoaae,n aecrcaore annnoe onrea oeraamemena more useo anaureons. zes aaaowaram o an examerocessoenerae a numer oaases camsaa annenoormmacsona sao,r aeccor annnoe ornaeeaa reosora soreseansurance ure usraes aarammac r or morememenaons. comuer ssem wn eresenaon o a macneneorm o aoerorm an one or mo wrec o ae se m oeonsoruoceosns mscaussee exeecueor causne macnememena ren, accorno one or more axanes.ureons..eneeves reos- , reos , anreos- reosauxraene.nvuaeneeraonsreos ,reos an axanesur.es..eraons reos , reos an reos- ttorneoceto.: uurree.aan-eraeeornsurvesreeosc -n rea a-n reos- . rea-wormeosea worveraurvvarw,, rea seroressonrw , an rea-wormeoex measmaenc carswraonn-re csaseanorzreos muaonsamcaon sausne sen o sames anure ~,.aen msuaoa rne er c ueanuceenrcmn m. naona coor,ncun ~, muaon cassr enc o sames w muaonse an amno ac. aa . ooosanesruon o muaons enesncuure, am e a.n rereo a ouc reenc. o co-occurrnene muaons w m vs. -. o. muaons on c assa. * reerso..,ncunoo oerenesure.uanass o co-occurrn m, oerenes, m, an u w urree..u om anae.rsaso ons c an scoreseween m an - aeraonsn exons an. oo-o-occccuurrrrnn aeraomns exon, exon v, an mue m. o-occurrn aeraons , , an s-. non-o-vaue..sn-seser’s exace . * reers rorusr-ene.erman. o oaesenns.ans. ro ce-r aer ors-aneenseraa c esnesn aer seco , an a enueren.-enneoera. aere mceraonsenen a. wase mosreuen , oowe, ,, , , , ure.aes oarea an . nraeac un e aeraonseeconn .naens w uson, er-onesn on n=, a an muaon, an an uson.esee raecee, muaon, amcaon ssue s were wne rane o raes reoreneeraureor muuarees on,.n.ea,-wor sar oeucomereas an wasns.moans ovo csen-ensa:vea reencesv wevo ansen, ttorneoceto.: w rvecoesveen cenm=oeraa n,ume rreccaevem oroevree rra.aens w muaonsreae ose recevn cemoeran=rw:.w :. a-n. rw comareo =. rw . :.- vs. vs. :.-., erence :.- =..ere was no :.n- rw. neow seeonwna.ens recevnvosn vs no. :.- vs. m eoownescron anerawns sucen usrae seccncoremoeranea sornuscuor ean,aoecao,se e secreca,nroec aerssoracceem.ermemenaons ma somemmenemenaon , an oer canes.orons aneaures o me s maencuen, or susueor,ose o oermemenaons. oareonasa seso nreeneeo ca unmser esnacnomases ae aavvaora oe euumvoarsens oose cams.reamens anuenes ousee seecve c anerormance o oenesne an conuce e onnes o ranomze conroeras, wor even nes w a commercaneresner success.ea- moec ce , secca e use oaaaseseaurnnerae cnca an mos ouaresaea,aaaasse asnenacrueraesnenommconroan roenrecson oncoo researc.owever, enera aanoss,ue rmaonromumormeo a snemeon,umor secme naroeracca caenes oenomcron o sera ose naveo snssnem reca-rweaormen c,nceasera ecvcee.nceenoamcreaamaenorumorss oenmeoumorenomcanscae aneaoru ress s can sncan aere assa w rc cncanormaon can ance.omnnaarom auos unersann oumor evouon ane em overerceonmcee oesoem caraeresneas c aonnere ressmancreove ueeeveomen o noveeraeucs aressn areas o unme nee. o am o sam sames e.ea cmanese c aannncouoecao samssueess,o suace arom a suec. same cane a woeoo,aees, serum,a snown or susece soumors, enoea ces,ssueoses,s cmerae, srooso,n raeuoo s cneovs,a wue,oom ceasc orueu,co acsceess, ttorneoceto.: cruev,cunaerrsua, oorn eex mraacrreowu,areuura, euesouns,n saceseween ces,ncunnva semen, swea, urne. cererosnau, sava, mucous, suum, ereo, an urne. sames arereeraous,arcuaroo anracons een sueceourearmroec ceassnneon remeoovrem o orr an caomsooneanes, sruocm a as s cueesc, o orr e cnarnave one comonen reaveo anoer.us, areerreouor anass cor conann ce-ree nucec acs. same canesoae sasma or serumransoreo a se o same anass.e same m or oanerom a suec anemeraure, e.., roomemeraure aereserve an se a aesrae oanerom a suec ae se, o°, -°, anor -°. same canesoae or mamma, an anma, a coma e same anass.e suec cane auman, a cancer.e non anma, a servce anma, or ae.e suec maave a av suec ma noave cancer or aeecae cancer smom.e suec ma aneoeeens,r veaaccene ws or onoeo or mcso.re cean scuerecer maa, ee..n, a rnem osnseo or more o cemoeraes, noeanose asen susceeo cancer or ann c.ae suec ma or ma muaons ncer-assocaeenec xemare v vso oor uummer ees. s o area.sm-a caneen oneesre reaeor seuence reons. m, m, m m, m, m, m-, o mr, m-. m.e voor exame,e voume cane.o m. ume o sameasma mae euvaens s.amore e cxaanm coem, ar ssaem vaero ous a aomuouns n o nucec aca conansenome aoumanenome euvaens an,ne case o c can, c aonoan aou, anouvua,oanucoeoume manoeecnuomese. eumvaaren, a same o aouu n o o cnan cxonannvua s an,ne case o c , aou on ree oe s m saamoec meeu su ceasn. ec co,mrormse ce nusc aenc a cce-srereom oeeren sources, e..,rom ces an ce- nucec acs carrn muaons.or e ren suecs. same can comrse muaons anor somac xame, a same can comrse carrnermne ermne o a suec muaons.ermne muaons reero muaons exsnn o a suec, e.., cancer. ceosm.ac s mamuaeon csan re ceormor msueaons o crarrnann cannce sor-masasocc caees ttorneoceto.: m vauraanons.e.e a. c., ceamnccear-a osrsocae somac muaons. same can comrse an eenec w eresence o aernoeecn m vaoranca suocn, a ws aere cannceer- eassoecnaeec v maruaanosn. assnoc soame emomens,e samencues an eenec varan assocae w ere e enec varan, werene sameoes no comrseeenec sence o a rom aoxuemaro a amoouuns o, c ee-ree nucec acsn a same vaeraonre. amcaon rane exame, .., o n, no n, no n.or aou ne, a umouon a coane uo aou n, uo aou n, uo aou n, uo o ce-ree nucec acu moec n, uo aou n, uo aou n, or uo aou n , aeas , aeas u, aes.ease amoun cane aeas, aeas , aeaseas n, or aeas n o ce-ree nuc,e aeas n, aeas n, aeas n, a emoram, , ,coram,c ac, moecu,es n.,e amoun cane uo n o ce-ree nucec ac moecues.e meo can comrs n, n, n, or o n. e oannemoram ce orne o-erre weo nrucse nucc aeccs ac ares n reumcaenc acs no conane wn or oerwseouno a nucec acsncue , , nn a same aer removnnac ces.e-ree , s , m , crcua annrscereo,,ncu,n renom, sc , moconra snons, o anw- onereasce.n ma nuceoar rame e-ree nucec ac,osn can noen-cooune-srane, sonne n-scr, or arereo. ce-ree nucec ac cane reeasenoo uro ane, or ceearocesses, e.., ceuar necross an ao u secreon or reeasenoo urom cancer oss.ome ce-ree nucec acs are reeaseromea ces.n s ces e.., crcuanumor ,c .ers are some emomens, ceree nuome emomens, c s ce-reeea c n ceree nuc cec acs arerouceumor ces.n some emomens, e-ec acs arerouce a mxure oumor ces an non-umor ces. nuceoes,ree nucec acsave an exemar szesruon o aou - moecues, w w a moecues o o aou nuceoes reresenn aou o o nuc moe o aou nuceoes an a secon mnorean a raneeween raconaon oreoareso.nne- sreee nnuc wecc ac ces- craene neucsoecae acrso,m asoounnu sosuroonu, ar ae ttorneoceto.: s meaaranceureomecnnacue cse susc an as o cenerr noun-asooue comonens oeo u.aronn canese an ce-ree an ceuan orraon.ernave, cesno us aon ouers an wa r nucec acsrocesseoeer.enera, aer cean u ses mae use ssuc se ass s, ncuaceasce ac cosum cannsoe rermecove caoena wmnan asco oro sa.surer seccu carrer nucec acs, suc aso- , orroenor.suon- seuencn,rzaon, anoraon, mae aerououe reacono o e ceran asecs oeroceur mze er sucrocessn,e suc ase. oue srane sames canncue varousorms o nucec acncun sne srannerocess a, sne srane an sne srane .n some emomens,n suseue nn an an caanses c soenvse.reooue sraneorms soe arencue n scosurenaa roee vss ceasnorncueeec nucec ac anaes, an non-nucec ac anaes.e ooca sames ma nenec varaonsnooca samesrom a suec. e..,en ncueonuceoesrom cancer ces.onuceoes mae ereo.ooocmac same,s c , e.., m, sma s, or an comnaon ooca s mancueumorssue, e..,rom aos.n some cases, comrseen ceamreees ma“nccue”oo or c orrc suava.narcuar cases,ooca sames ma eres anumor“c ”.eree can carorxaan em, e. s,e.s, e ooo e nso. ,n-nruoceencs, acc aonaroeesnsncu-en,eu o arre n-onemeo, s, osoroens, seccosorae or aceae varans or ,oroens, oroens,roxaon varans oroens, oens, amaon varans on varans oroens, suaon v meaon varans oroens, uua enveoe, v arans oroens, vraroense.., vra cas, vranraceuarraro ceoans,, v anrao acceess,s aonr, an vraennconroeransm, venras se, ec., exraceuar an an anen, a suraceroen, arans .surerncues receor, roen canne, memraneroen, a cuser oerenaonroen, a a ce-cene aracrooennurmoe,n a ca crormererxo,en a,n a anoseno-rese,n anco coromene,x a, aco maor, ttorneoceto.: as cocmoemrca anen c roemceeoxr,, a ann e enxrnaeere-ce receor, a-ce receor, a-ce receor, e..,osoraon,c ceuar marxroen, aosransaona mocaon aon sae o a ceosaon, uunaon, nrosaon, meaon, aceaon or nenera,e s suraceroen, aauncon, an an aerensuncon. an num sems, aaraus, meos, an comosons cane useo anaze anaes.eorr o exa amnae,es,e nuurmerern oc aunanesoa n aurcee anca acze a cnaanees a aneas no an-onuuc,ec ac aou, aeas aou, aeas aou, aeas aou, aeas aou, aeas aeaseas aou, aeas aou, aeas aou, aeas aou, aeas aou a,o au, a aou, aeas aou, aeas aou, aeas aou, aeas aou, aeas aeoas , aeas aou, aeas aou, aeas u , o aou,, aeas aou,, aeas aou eaure or meo sruesraeere.ne anaosesorreseernormn an re muon oexee s aasmsase oor a wnazne anwon orv moura eren ana moecuarnerr mes aco wroen nsuce ne acsc au ocsse o acnaan a se su e ne o sse as mneu unoern e nro s sne-c unuocne o e.c. a,cs ce as snc ,aos weu csre c.o mnsue a se o as “neracome” –e moecuarneraconsa occurewe ae reare erenocemcaamesroens, nucec acs,s,en moecueseonno wn avenam.n varous emomens, anne caroraes, ec. an aso neworormeranscronacorsa racomes aroen- neracomeareenes.n oer emomens,nn or croman reuaorroens aner , orroennera eracome reersoroen-roenneracon newor anass oeneraccoon newor .e meosescreeren aowor su an woe exome seuencnm aen.ecn-seue,s a snuc ma asss sroeceoroemneomrc ass ewxamoeesen coamne su seouencn, oeneracome. r su n cancer,nea arses ssuenec m,eoos c caarnaceerz uese conooanoseresence o conons,arcuar eeroene o a cancer, monor nse.., san cancer oreermnn oeveon a conon resonseoreamen o a conon, eecronoss rs e useuneermnn ore s eusceacuen o c aourasre ocu aa cronreamonen. oeorens.enuccsecsossuurer ceaanm aesno ttorneoceto.: o suoencs's maooncreaesereaem aemnousn suc oce cssou a nsu mmoreer c vaanrcearso mna or rare muaonseecen exames,s ma no occur.n anoer exame,eras ceraner aen se .n oer correae wenecroes o cancers overme. s correaaomnen oons mae seecn aera. ona, a cancers oserveoen remsson a mearree useun resen meos cane useo monor resuasease or recurrence o amen,e cancers,uen ceasnc aenrs, n sumne cra once crasn,c neorsse caan mcears,eroeaec caenc meras,ncuesoeoase c.ancers,ran momas,ancreac cancers, sn cancer ver cancers,one cancers, aer cancers,ne can s,owe cancers, reca cancers,ro cancers, eeroeneousu cers, mou cancers, somac cancers, so saeumors, eeceromemnors,omoenousumors anee.e anor sae o cancer cane varaons,ransveresocn vs,arraansonoscanconus,nnve mrsuoan,ones,e raornes, m auneauonos,n,ears,a co aneu numoer, coromoosom,e cursoomnoss,omenaernusncaaons,, cenroem aomsomaca sornu,cuernee aueracaonosn,s, cenreomoussons,esons, esons, anorma canesn nucec ac cemca mocaons, anoorma canesn eenecaerns, an anor ma en ma canesn nucec ac-mecosne. cancer.aec an oer anaeaa can asoe useor caracerzn a seccorm o ma aown ccers are oeneeroeneousno comoson an san.enecroeaa anoss orreaaramceenrzaon o secc su-es o cancera maemoranne orraconer cues re oaran secc su-e.snormaon ma asorove a suec suec orraconero aareeamroenoss o a secce o cancer an aow eer a ome cancers canroressoecomn oonsn accor weroress oesease. ma remanenn,nacve o e more aressve aneneca unsae.er cancers useuneermnnseaserroorremsan.e ssem an meos osscosure mae oon.ueccreesssenu anreaamseesn are o asoon us ss meon au.nncereearsmenen amoeu en ocac co o a nuamrceura vrarreaaomnen rare muaonseecen suec'soo ereamens successu as more canc or e an se .n oer exames,s ma no occur.n anoer exame,eraser cse mareamen oons mae correae wenecroes o cancers overme.s corran mae useun seecn aera. ona, a cancers oserveoen remresasoonn ttorneoceto.: aseerasree.amen,eresen meos cane useo monor resuasease or recurrence o oerane canrecseer.n mmemuons can asoe useoreecnenec varaonsn conons eresence e ces, suc as ces, ma unero ra cona exanson uon varaoneec oo cner anan cersaeansems.munoen saa eexs maansoens m monaoree m.onnosre exa umsne, c coo numer varaon anass maeerorme overmeorouce aroe oow a numer maeroressn.o numer varaon or even rare mu arcuarsease eermneow aouaon oaoens canesurne caoneecon mae useo arcuarmoranurn croncnecons, suc ourse onecon.s mae were vruses ma canee cce sae anor mua ase oreasnecons, course onecon.eresen meos mae uno more vruenormsurne acves oeoso, asmmune ces aemoseoeermne orroe reecon e saus oransanessue as we as a esroransanessueo monor reecon. erne course oreamen orrevenon o an anormura ceor,ne moneos oescosure mae useo caracerzeeeeroene o o exrac n a suec.uc meos canncue, e..,eneran aenecroe aueuaronuceoeserverome suec, wereneenecroencues emoramen os, aana a rensourmna coronm coons n cuamnceerr. vanr saomoen e amno rarmee mnusaon anases.n some mae one resunn aeeroeneousenomcouao ,e anorma cononumors arenowno comrseumor c n.ne exame o cancer, some eeroene ma comrs esneren saes oe cancer.n oer exames, mae mueumoroce mueoc osease.an,ne exame o cancer,ere ave srea ,eras were one or moreoc aree resu o measasesa a summaeonrr oeosmen a en mr eema cor ns s or cmaen. aoen useervoeenreormae orerreon cee,snnerrn or se oaaas s se oaa ma comrse co numer varaon an aeeroeneoussease. comnao muaon anases aone orn oerseaen. serse.sen meos cane useoanose,ronose, monor or oserve cancers. or ronosn or monn soormne e ameous amnen ass, suce m aree noosreecreenoo n noon-nnvvaosvveereenaaaneossnn,. ttorneoceto.: na onoesre, emroonomsee,n mso,noerse or m oeseorveo coaes mae emoen arenan sueco an oeronuceoes ma co-crnccuerase o wr oe mraesrenaase msone acnu uens.orn suec wose esuerme-naaseon s oeu-emncen acno vsanreanaseren o nucec acs meaonaern o a nucec ac. reoroves a means oeermnne aernncuessnusn-mn some emomens,eermnne meaon some emomens,eermnecosnemrom non-meae cosne.n meaennerom non-menae m aeeaonaernncuessnusn - meaonaernncuessnunne.n some emomens,eermnne ormcosne , an-caroxcosnsenca-rroxmecosne m,- osue seuencnncue,u are n om non-meae cosne.xames se,e-asssesue seuencnomeo oxavesue seuencn -- se. -se, an reucesue seuencnre- m,xrasv ceonvseurne seeuenmcno-, an-seensr useosnuseweenm an revousescre.e-asssesue se oceen wsue seuencn as snusmc anm.n -se,msureoncecne -se can asoe useo en useo convermocaeoreroceen ucosaon.e enzmes escre.eucesue seuencns wsue seuencn, asrevous enera,nsue seuencn, u as neuosnus rom moe cosnes. an one auosreae wsue.ecesuc ac samesvenowo auos moe cosne nuceoese. e convers nave cosne an ceran oer moe c .-ormcosne or-caroxcosneo urac wereas convere osnese..,- mecosne,-roxmecsosne are no wc c.osnoems waerrseo ann o w nuecree nco ac con sveerueencoes u orac mos.ecuoesromewo auosncaes an were no moe caneeermne. nseuen, cosnes wc weressavanaeousor sames conanena sn oe samenowo auos comose oeeroeneo n on sma amouns o nucec acs, anor eresenscus cessue orns suc aso us conann ce-ree . ereo.ese meos woosrureronvnes n mueceoc asc asownn aosuuaoen seo aue cnacnure a mnoe var,a.ne.s, ttorneoceto.: aoane, avan c,a snreea cvaunr,e a n ourcemcm aocznecu.na aure moeesncue, woumaon, reconze an ano, an man arcuar nuceoe seuence, aaen e a memer o annareca aracaearces.e exracon moe can emomens, a caur , suc asonsreavn oraenano.n some wcs aaceo anes mooaeaas aaceo an anaes caure snnar arcea cane e moe, suc as a maneca aracaearce or aare moecuea semenerou cenruaon.e caure moe cane ane o nucec acsa aconws ae cnaur see maoraeon. oxe nmucaerc c aacusree maroneese are caourne w moce aroom an searaon nno sreavnn ws oonu e ornaeo a so ase or an oonucceeoe, wc aows an searaonrou nno a comemenar same nucoece acnse, oer samnae neucoe ac so acs searsvee. asoemowanesnorn am o cacauorne. mooeeso amcaon,e ornaemaes remanneoe caure moees,u a own noneo caure moe mcons are wc mae c aasourer movoee a ce masn.eneo same nucec acs as a comonen o an aaer, meos, same nuc caon anor seuencnrmernn ses.n some a caure moe ec acs areneo aaers ao ens, wo aaersearn meco.reera an cosne resuesne aaers are moe, suc as moees aresnne,eooroeec o arannaseme acaeosn o a csueavae.en snomaeense.an.,ces,ooece caavure esoon- or urac resues ceavae w ™ enzme,em.ommaune am. e : - ,n wc casee caure . e remove moees can,esre, rnaee. m amaecsonsn areoenea auren an rea coennac weer weas n aunc aecn ac re maoenecuoerse caurea. amcaono no.us,e ornaemaes cane searaer resunrom resun om nucec ac moecues oroomw anm secaaraoonn. ornaema oraron,e resecveouaons o nucec acs.e., ornaemes an amcaonroucs cane sueceosuereamen we ernave,aee amouacoano rnecerovnucs csaunee sureaemceeno ansue aemreamcaeno annroeu ocrs nnoa. ttorneoceto.: aemmaeewoucaonnes c naose. ooeow ornn saucemreaaemeon,uaeon re csoecveouaons cane eouaons can asoe sueceoonroerznvers uracsomnes. resecveouaons areen anaze an seuen aonor enrcmen.e cosnes were-meaeor-roxmeaeces comareoeermne wc nuceoeneemaeouaoncorresonno an une orna.eecon o a urac an a nuceoe ae corresonno nmeae cosne convereo an unmoe.eresence o's a corresson oe ameouaonncaes ameouaonsncaes a moenoen ornnosons oe ornaemae an nra sromere emaraoonme on ms,o ae mceuaora usees seuenaa sa rares.-msee a. snrocseusses-seerorm-se raen o aaerse..,on, -se amcaon o woerar,aren moeecue eemcovoermene.s,. sere maevoneenaeus-mowen,csousnee w conve srnsone- aanse reso-sueo.n,nr some sesuena -rearave amcaon oarenrar moecues w an wouou rueceonarea amaen. s cane aceve mone-me-ae -aaers aaee..,oenrs on-saeore w-mecosne reacn usen-se w ae, an amee one oewo aaer srans.ame moecues are aaer en,e cane seec.., .s onearen moecues wave aaee aaer meose.., sr ve recovereromer ameroen ae-secc caure mars,s eavn-maneceas.searen moecues rean-meaon meaonue converson one caurerar we sne-ase resouon- n some em soaumse unso,ne-ssue, reearenane moraercu caarnneo crmomaonneo w corre as noonn-rneae-se. roro enrcmen aon o a sa rar w mea seuencen sanar muexe eorow.s w -se worows,onormacs anass cane carre ouor anomco a seencmveen a rnecov-emreeaaeren,aseaeen moceacuone.s, cnar srumn,-sm meeocosronve mesae aerrar amcaon,ere aownoraraerocessnorsue cors, .s overcomeseesrucve naure osuereamen oneua nvere oe -senormaon exracerom a worow. s meo,es reencsov ae,aren moecuesvaaee aaers aow amcaon oe comeevere ttorneoceto.: rersaern anscoasruaree ascussceasone o user oeamen-sse mae eocs eenec mocaons.e mecosne,uss nomn.arans o-oseenav cosne-meaon- roxmeae cosnesm --se, -se,oermeenceovsenoeoen se an caroxcosnes. ese meoooes canememenee w re- seuenaaraerarrearaonescreeren. e ernaveeos oo meaee,sncoesureorosvoneess a anernae oveer m meuc ooecscaocro annsanazscnss u moe nucec acse.., meos, aouaon o nucec acsearne sse aove.n some suc ,,, or more me rouser nuc mocaonoeren exense..,,, raconaon oeouaon ec ac moecues conace w aaerseore eer one en oro ens eenn one exen oe mocaon.aers aaconcueer o nucec ac moecuesneouaon.reera,e aaers a enas o sucen numersae numer o comnaons oas resusn recoewvnroae sam ee. c.o,m,na oorn o.as o.wooo nwucnec a acacsm wen oe a saameer ssa,r aen nu scoeons are ameromrmersnnoermernn ses wne aaers.ca acs weerearne same orerenas, canncuee same orer ers, ses,ureera aaersncuee samermernn se.oenrmernn e nucec acs are conace w an aenareera ns own amcaon, mocaonsuc aserevousescre suc a o nucec acsearneno aeaswoaronsernne exens.e nucec acs are searae mocaonromnnoe aens.or exameno wce nucec acseare earne mocaon, nucec acs ov e,e aenas anor nucec acs mean reresenaonne erreresenene mocaoncomare w unerreres ouaonreerenanoe aen, wereas nucec acs oown seenaeraoonr,ee moerecnaonaroo nnos cann oern aree s muoreec easour eueerrorocmessne a sen. wc cancueurer amcaon, an seuence anass,narae es, euenceaaromeerenarons canene comare. u searae. ses anuacse.c ace mso caencueesn aree am aoe e.nseo am-saee m aoaeceursesn acreuennrracmeornanen ttorneoceto.: conneacar won annc anueos orrenaer menoeacuesnacnno m-emeaocn aonsn aeoroucewoarons.os meaon.e oeraronncues orna moecumescaon coesavnwoarons areenrocesse an seuence searae wur w meaon.e meaearon.e seuenceaa oewoarons canenere amcaon oe exame,as are no useosnuseween meae an unme comare.ns raerosnuseweeneren moecues wnesearons soaea oneu eermne weer reas we same sar an soons arease one sam can moecues. e oreren wc aeeass scomoseur oeroev nucesecur acers mnecuoes onoer a onra mozn aouaon o nucec acn as-mecosne an an oe oer mocao re moe cosne resues, suc eouaon o nucec acss conace nsescrerevous.nese meos, resues moe aeoson, suc a w aaersncun one or more cosnen suc aaers are aso moe s-mecosne.reera a cosne resues aaers are moe.aers a, or a suc cosnesn armernn reon oe reera,e aaersncuacoo ens o nucec ac moecuesneouaon. comnaons oas resusneerenas o sucen numersae numer o e same sar an soons re aceowroa e..,, or. owo nucec acs wn suc aaers canee savne same comnaon oas.ermernn ses aaers,e nucec me oreren,u arereera e same.er aacmen o e aaers.e am acse are nu ameromrmersnnoermernn ses o auos assaeor seuencec acs are snors an secon auos.ers moecuesner ceaa w or wouurerrocessn.e seuenceaa on e nucec ac mose auosuseermnerresecve oena meaon sae o sue.srcues.e nucec ac moecuesne secon auo arereae w ac eamen convers unmoe cosneso uracs.esuereae nucec ose ar aeen sueceo amcaonrme rmersoe ornarmernn ses aaersaasersneo nucec ac.ne nucec ac moecues ornaneo nucec acs resannc croomsn aemsncearomnerronucns sereeso o aree a noawe arms, weareaes aemcausecaeosne coronvuecrssonavoe uroascsen meeasuone oreaemseen c.osneus, re osnues o,r wnac moaveecu uensenronee ttorneoceto.: oesuea nuocnes,c a aceass s aorem seu oe wcco a sereu meae, unero amcaon.er amcaon, romecrso anua s ence anass.omarson o seuenceseermne nucec a eocnon wer ae suuoesc caon mnecaaeo amn.on oerns, wc cosnesne nassa oronenneceameno aura ousamessecs oames n ceran emomaernacerscs acse..,er sescreeren, aouaon oerenorms o nucec c asescrmeeeae an omeae n a same, suc as a caure se o oe nucec acsrreonr coanureer asncaass,ar e..o,neeraesnea on on meo or monre c orarsaocaernsc as n wuceeoeras cee,raan sne,u aennceosr a sereuencenrm.esa aer oorac caone useoeermne,or exame, ermeaon varae eenecare reo meae.n some emomens, sowermeaon caracersc ns are anazeoeermne weere eenecare reons are an oumor ces anoromeaon varae caracersc oumor ces.azeoeermne weere sowomeaon aouaon, one mancrease rare snoanas, e,..,a ernrconnn ra are neuecroecen aecous mo nueccueces aca vraera moornerreesveanennn oenre-mreacoaneoraruones osore noounaono.meor exaamee, aenec more easeece aronn a samenoer-meae an o-me canae nucec ac moecues. anazn mueracons o a same, a mu- e anass o a sneocus o aenome or seces o nucec mensona reaer s ac caneerorme anence, nen ssov cane aceve. aronse.m.e, ansaenacses,, a,ee,roe onreousa nrucoencs a.cn s saommee emsoarmeonenowo or more erenaae.aearons caneneooeoeerorns, eacarons anor seuencn.earonn-an-oon ses c coecve samere roun oaronn occurrnas an occur morean once, w eac anae usner e on aeren caracerscsexamesroveeren means. enaasa aresnuserom oerarons anaronn xames o caracerscsa cane useoraronnncue seuenceen, ttorneoceto.: mreoenasonaevne, nouceoso.meesunnn,ar seounensc cean mnsmcuace, onmem ounorecaon, anor nucec acorms: sne-srane ss ,oue-sraner more oseo,own ramens anoner ramens.n some emomens,aronnase so orer cosne mocaone.., cosne meaon or meaoneneraserormen as oona comne w aeas one aon an an oe aaronn se, wc maease on ouaono ore noucne cca arcacsersscasr oroonremsn oo nuc.enc s aocmes e wmo omneen ors, m aoreeer eoeenneeoucs m mocaons an woue one or more eenec mocaons.xames o eenec moecaaonsncueresence or asence o meaoneve o meaone o meaoone..,-mecosne versus oeres o meaon, suc as aenne one n anor cosneroxmeaon an assocaon aneve o assocaon w ou oaro mno ore nuroceencs a,c susc ca ansesaornes.oneernnao nvuece ocr a ac mooneacu,es a asseoceraoeneous nuceosomes an nucec ac moecuesevo o nuceosomes.ern e w aeeroeneousouaon o nucec acs maearonenoa sve or aona, sosuaon an o nouuceec-s acrans meaearsone.aseern oan nvuece, ocr a aceonnan e,e . a-sr .,ea men oroe eceneous uo an moecuesavn aen or ues o n somensances, eac eaeran . erenaaee, aneaarroonreresenave o aeren nucec acormsnsances,eerenorms a ns areooeoeerroro seuencn.n oer eren nucec a re searae seuence.n some emomens, aouaon o reresenave ocssaronenowo or moreerenarons.acarons susamenc aeren nucec acorm, an arsaronaso reerreo as a susame.acues w a cosne mocaonn areaerrooronan a secon a aecs ars naurconssncae.ers susames sueceo aroceure ers susame, weoereasnene erenrom a secon nuceoasene o secon nuceoase ers nuceoases a moe or unmoe nuceoase,e aners nus a moe or unmoe nuceoaseerenromers nuceoase,ae nuceoase ane secon nuceoaseavee sameasearn secc.e anaze,cneccu acnso aresonoeusoeeerrsr nourceoo seasueenrocmn.ee seuceonnce n ruecaeso araese onanee an ttorneoceto.: ooeeecrse snuescam varea,nns s canco.eaerso arrmee use ono sor reasromerenarons.nass nucec acouaoneve.or ex aaron--aroneve, as we as woe enec varans, su ame, anass canncuen sco anassoeermnenosvaenrces,n c as , ,ne,usonn nucec acsn eacaron.n some c sco anass canncueeermnn croman srucure.or exame, ear ceo over saeeue cnacne c roeraresa cean we useeor nueceermosonmee nu occceuosomeosonnn croman.ower coverae can correae wower nuc ancnenomc reon we . eosome occuanc or nuceosomeeee reon mocaamonseso c nauncencue nucec acs varnn mocaonsncunos-recaon n an emomoes annn, usua noncovaen,o one or moreroens. oroo samerom aen su,eec sousueacoen o o nuacvenc n aceosass oan,e a oumaonre, orr coamnc aer se orrum,asma anose w neoasa, aumor, or cancer.eouaon o nuc revous acsavn varneves o meaon.eaon can oc ec acsncues nucec recaon orranscrona mocaons currom an one or moreos- mocaons oe nuceoe cosne,ar.os-recaon mocaonsncue -mecosne,-roxmecoscuar ae-oson oe nuceoase, e.., an aens cane anoes wnee,e-ormcosne an-caroxcosne.e varansereooc e a.,aoec:sre secc, naurannarners or - , or arcaees seece e..,-aesaoonav ee s ae.,cacoec:are. o aven sx anam mees o canunre mrooeeness conesm asaeescerenncue me nnoman e a reeren,ncunroens suc as erennorm ansoesreerenanno-mecosne.ewse,aronn o searae o nucec acs caneerorme usnsonennroens wc can sone nnucnec arcoesnsouna coanseo unseesronmeree or unoun nucec acs.xames o an oma meosscoseerenncue , nnoe aen ma onccuernes.ouor some an aens an mocaons, nucec acears a m an essena a or none mannereenn on weer a nucec acs overreresoenecano an m,oe sceaaoranonn moaee a oenne o a aereraeee.r enx seuncans nauncceesc, ttorneoceto.: a mcas unnerrne arnes aene or nnoen mo mancnaer.on.uerenna, vvaero, nucec acsavn mocaons seuena useves o mocaons mae or ex eaumee,romenn aen. o mocao n some emomens,aronn canenar orase onereeeve rame ns.or exame, a meaeramens canearonerom unmeae nrcmnesn usn meermo-snernceomanroense..,e nereae eunramensavnerenenvc.useuen, aonaaronn manvove a souon w e me-nneosm oa mne anaon ausne sa concenraonnncreases,ramensavnrea ounramens.s sa concenraon arons are rer er meaoneves are eue.n somensances,ena overreresenavees oenra unveer ore nreusceneacv aecs oa mvoncaeornesn. exveenrrse orese mnoaocna aons unerreresenaon caneene e numer o mocaonsorn a nucen reaveoe mean numer o mocaonser srann aouaon.or ex c ac mean numer o-mecosne resuesn nucec acn a sames,ame,encun moreanwo-mecosne resuess overrerese a nucec ac a nucec ac w or zero-mecosne resuess unnens mocaon an an searaonso enrcor nucec acs ove erreresene.e eec oe ase anor nucec acs unerrer rreresenen a mocaonn aoun souon.e nucec acsneesenen a mocaonn an unounase.e.n en usne neroeunaease cane eueeore suseuenrocessn. varouseves o meaon canearone usnnrcmen ermosercenc omeaearone.., no meaon cane seuena euons.or exame, a conacne nucec acouaon we searroamereom, a w meaearon maneceas.eeas are useo searae oue meae nucecs aaceo meae nucec acs.useuen, one or more euon c acsrome non-o eue nucec acsavn ereneves o me ses areerorme seuena meae nucec acs cane eue a a sa conc aon.or exame, ars se o m, aeas m, aeas m, aeaesnrao mn o, a mea orer, e.., aeas m, aeas m, aeas m, a s m, aeas m.er su eas m, aeas m, or aeas searaeecr mevees oa mee nucaeec a ncucse arce a ecuser,o mmanoesec w searoawoenresv oenc oe a maen usaeono. ttorneoceto.: suce e asu aon anom meanaeec seararaononre seresse cnana rveeaemseveso creae varousarons reresenave ooweve o meaon, ane a o no meaon, a meaearon o e er meaearonreresenave suecenv se oo am o we m a me se seoa .so,n neu.c wec acsouno an aen useor an searaon are aen.uc nucec acs canas se wases o nucec acs weaounoe an coseoe mean or m e enrcen nucec acsavne mocaono an exen so ase an ean.e.,nermeaeeween nucec acs remannounoe we aen. nucee ac acns n sonnoe so ase onna conacn oe same arons o nu earaon resusn aeaswo, an somemesree or more searae,e ncec acs w eren exens o a mocaon.eearons are s a ucec acs o aeas onearon, an usuawo orreeor morearons arcesnneoer neunceacr aconsa resc,e uvsunareorvenea ass coamosnennsu os a maemeresr,s w o onee naruceoc rom anoer.easneo nucec ac moecues oe samearon caneen orerenrom one anoer.u erenrom one anoer,eas maa same coen common so asoen e moecueso wce are aacev aesar oer arcuararon.orurereas rearnoronn nucec ac sameen o a caracerscs suc as meaon, see , wcsncororaesearsee on reerence.n some emomens,e nucec ac moecues canerac n aronsase one nucec ac moecuesa areouno a s onaenoeren ereo anosea are noounoa seccroen oreccroen or aramen ucec ac moecues caneraconaease onram-enroeenreon. comexes caneraconaease on a seccroer o aroenn.roen- sucroeresncue varous eoes, mocaonse..,son.xames o aceaon or enzmac acv.xames oroens wc manoe me anaon or aassorraconaon mancue,u are nomeo,roen anr serve as suae meo cane useoraconaee nucec ac moecuesase oen.n reons.xames o meos useoraconae nucec ac mo onroenoun oun reonsncue,u are nomeo,- , cromaencuesase onroen ,earn cromaora, an asmmercaeowracon-mmuno-recaon n some emomens,aronn oe nucec acsseroarmoen co.nacne ttorneoceto.: n“ucec” ac.s w an mseo-ameoncnonsneomman.“ ”s o c a meaonnnroen suc asnaeas- reavn v oueoaramaneceas, eren exens o me a aonner.aronnnoracons w concenra aon caneerorme eunraconsncreasnea raresno ro enx.emar meoor moecuaraencaon o -eaarone sucaarosn ansoows: rom au o an exrace samee.., exraceooasma euonsrmoman sraomceseso ursnow an mseream-rnocenomanroen-eaurcaon, savn ao eacaraareo an.caoro enx oamee,renea moss erecnu.aras an -enan aaer seuences omeaearons meae, resua meaon'was', an e-comnn a m aroeeae w -aaers w moecuaras. aaer-s cuaraearons, an suseuen amcaon usn enomcn rereccomc nse onnerrrm eszear s e.oe .nue , ca once nce rs re. -s-coemccneene anc va armans aenoaerenarar,aren reons. meae sames aer-eamooeca anon a ossaee ennr mcueoa rar, aenn a samea.eren onormacs anass o eaxa o,n w anensrumen. unue moecues, as wee moecuarasen useoen -arone. s anaconsvso cuanon oeen saomrmaeonno o mno reecauevsea-m weerecerena enomc reons, concurren w sanare osneor xames o s conema nec seuencnvaraneecon. ae s aroenreereenerenncue,u are nomeo: cosne. anno-me-cosne over unmoe -roxme-,cosn aen oe msmac rearroen reerenano over unmcoe c,osneu,ver unm raro e,oe c a.,enom anosne. eo.:reera no-orm-cosne noes secco one or more meae nuceoease.s. ttorneoceto.: moecuensaevnenra m, eorue mones aauonnc eounn o u nnumerenrc orea mseeae seser moecue, w nosncouaonsase one exen o me saa concenraons.o euee euonuers oncreasna concenrao on, one can use a seres o no aou ma.n one emomne.na concenraon can ranerom aou oecues are conace w a souon ,erocess resusnree arons.ncun a me nnoman, w a ars sa concenraon anncun a moecue as sreavn. ers sa co c moecue cane aaceo a caure moe, suc an aouaon w reman unnceonuraon aouaon o moecues wnoe “omeae”ouaon.orn ex.ame unounouaon cane searae as a omeaeorm o sa wc reme,an as unrsouaron reresenave oe m or m. seconaron reresenavn a aow sa concenraon, e.., eue usn annermeae sa concenraon, e.e onermeae meae s concenraon.ss aso searaerome sam.e,.eweernar m an m ermeaeorm o s eue usn a sa concenraono,n reresenave o m. e.., aeas aou wc aeeass scomoseur oeroev nuecseucr acers mnecuoes oonre a onra mozrn aouaon o nucec acsn as-mecosne an an oe oer mocaonse moe cosne resues, suc aeraronn,e susames o nucec escrerevous.nese meos, more cosne resues moe acs are conace w aaersncun one or cosne resuesn suc aa ae oson, suc as-mecosne.reera a reon oe aaers a ers are aso moe, or a suc cosnesn armernn eouaon.reere moe.aers aacoo ens o nucec ac moecuesn numer o comnaora,e aaersncueerenas o sucen numersae acs we same snas oas resusn aowroa e..,, or. owo nucec nn sesn suc ar an soons recevne same comnaon oas.ermer aacmen o aers canee same oreren,u arereera e same.er nn ses o aae aers,e nucec acs are ameromrmersnnoermer ers auosaers.e ame nucec acs are snors an secon auos. aa o assaeor seuenceaa w or wouurerrocessn.e seuence sae on moee ncuucesecn ace mrso aecuueos.seus nuceeercm ance mrroeseceucesven oee sencona m aeuoa aorne ttorneoceto.: s nuuceecoeaseon aroeceure, wae arenecse arrss n nuucceeooaasseenncuees a erenrom a secon oson, ane secon nuceoasencues unmoe cosn ceosne moe ae suereamen or anoerroceurea convers unm .sroceure mae nucec acs sueceoeroceure areen ameoe cosneso uracs.e nn ses oe aaersneo nucec ac.ne w nucercmersoe ornarmer neo aaersassncrom amcaonroucsereo ar ac moecues orna ese nucec acs rean cosnesnermernn sese now amaeecause amcaonroucsaveose meaon oese cos onee aaers, wereas unerone conversono uracsnesuereamen. resues, wcave ouaons, aeas some o wc are meae, un us, on orna moecuesne ese nucec acs are sueco seuence a ero amcaon.er amcaon, ers an secon auos ca nass.omarson o seuenceseermnerom acouaon were sueconncae amon oerns, wc cosnesne nucec aronunc, m ane anaaess cane me senroeramoen. o u-ssnaee aoaown exemarroceure.er nn ses an ers ao ensncunrmer meae.e maos.caeo cosnesne aaers are moe aeosone..,- suseuen converso n oe aaers servesoroecermernn sesn a aoe n see..,suereamen, converson, or an oer converson o aaser nso, aece moe cosneu aecs unmoe cosne.er aacmen auosor seeuencn m woecues are ame.e amcaonroucs snowo cane sueceo an wou converson.e auo no sueceo converson sueceo ar seuence anass w or wouurerrocessn.e oer auos nuceoasenoceurea aecs ars nuceoasene erenrom a secon oson, anee seco, wereners nuceoasencues a cosne moe ae suereamen on nuceoasencues unmoe cosne.sroceure mae rmernn r anoerroceurea convers unmoe cosneso uracs.n conace w srmesroece mocaon o cosnes can suor amcaon wen an no coe ers seccor ornarmernn ses.us, on orna moecues ame mosecruomers amcaon are sueceourer amcaon.eurer romewo aeuso asr.esenn sueec seearoa seonue scnceem aneasscsu.sseeu aenocvese, ca nnuceenc aec comaasren ttorneoceto.: asaneruss are nu ncoec u asec mooescunesu wsneweee snam meearaoen. an unmeae uo e uecernenerorsusameo aroceureaecs arsuceoasen eosmsc aoseeconerenu ccoemorassene oersusame roceurea aecs ars nuceo e a se o suecners susameo a e oers susame, waesene erenrom a secon nuceoasen nuceoase,e secon reners nuceoases a moe or unmoe rs nuc nuceoases a moe or unmoe nuceoaseerenrome secceo.ans seo,m ane emeorsm neuncse,oasee anrs nuec seecoonase nusc ae mooaseavee sameasearn ene secon nuceoases a moe or unmo e or unmoe aenne, moe or unmoe cosne,ene sec e aenne ers nuceoases a cosne ers nuceoases a mon nuceoases a moe or unmoe nuceoases a moe or unm oe or unmoeuanne,ene secon unmoemne,ene seoeuanne an ers nuceoases a moe or moe an unmoe ucon nuceoases a moe or unmoemnewere s se. rac are encomasse wn moemneoreurose o cosne,enne s some emomens,ers nuceoases a moe or unmoe nuceoase ma comecornse n uuncmeooasees c a mosonee o arn unmeo seceon c nuocsenoe.asoer exame,rs one or more o-mecosnem an-roxmecosnem ma comrse secon nuceoase ma comrse aners nuceoa .ernave,e anm.er comnaons are aso se ma comrse one or more o m eoownscusson osse, asncae, e..,neummar aove an ane oernc , suc as were one oers an secon nuceoasesncues m erenromnu a soe sms eceo em nm. noucmeoenass,eneroeceure oa aeecrss a surssam nuceoasene converson.reamen w sue convers unmoe encuessue cosne nuceoese..-orm cosne or cosne an ceran moe wereas oer moe cosnese..,- -caroxcosnecao urac convere.us, weresue conversomnes usce,osnee,rs- nucroexoamseenccusesos onnee o arr me noore ttorneoceto.: o ae ucnemoesu ceo,s anne,e-o sermcon c nucoseonea,se- mcaroxcosne, or oer cosneorms suc as m an oonam.euencn oa comrse one or more o m anm, are rea as cosne asen m ormosonssue-reae enesosonsa ene asen or asue-susce .eanwe,osonsa are rea as are cosne, or-caroxcosn eorm o, suc as unmoe cosne,-orm escreerenu e.erormnsue converson on ars susame as seuence reas oanseacraesennosons conann m orm usne converson, see, omers susame.or an exemarescron osue n e s.o.m,e eomss eo am.,enas,oemmroucne.ur: .. erenrom a secon nuceoasene e oa aecs ars nuceoasene suex- converson.n some emomeers susamencues oxave nuceoasene erenrom a secon nns,eroceurea aecs arsncuese-asssesue converson.uceoasene oers susame aecs ars nuceoasene eren n some emomens,eroceurea rs susamencuese-assse con rom a secon nuceoasene oe oona werene susueo verson w a susueorane reucn aen,er-uamneora rane reucn aens-coneorane,oranerne, a ne, or ammonaorane.n some emomens,eroceurea aecs surssa nuceoasene erenrom a secon nuceoasene oers oonmae wnceruenes ce seumscau-aesssoeran ceo rneveurcsonn a wen as su-scouneeoorraannee reucn aen,er-uamneorane, or ammonaorane.n some ,oranerne, ars nuceoasene erenrom a se emomens,eroceurea aecs susamencues -coue eeneccon c nouncveeoasene oers n some emomens,roce rson. e urea aecs ars nuceoasene convreernson orome a sresco nnuc neuocaesoe,a es.e.,n asen-e o.eee, ers.. s,uasasmvaen,cues enzmac se:eecon o meaon a snease resouonromcorams o e a.. - : v.orconen........,v.or exam av oxv www.orx aeae a e useo converm anmno susraesa cannoeeam,na an- can e.., , anen aeamnasee.., cane ueseo aeeaammnnaasee ttorneoceto.: unmoe co erenromns a snoe sms ece co on enmve norn ucemoene assm e,o ne urra eocces.ure oae aerscs su asrasm nuecenocuasene ornancuners nuceoaserom no ornancues searan nuceoase. ners ane seconn nu socmeoe eamseos am menos,ee ors nuceoases a moe or unmoe aenne, moe aennes-mea r unmoe aenne.n some emomens,e one or more o ennem.n some emomens,e moe aennes ormaenne -meaennem,-roxmeaennem, or- useo searaeec.nu ceosncun meae mmunorecaone cane umar e a., nann moeases suc as mrom oer .ee, e.., seccor mronseersscrene. : reer e a.,e :-.n ano moe nuceoases, suce asnourmns e o a.,moensesaurascncu:na-o.enaneooremsso surc var aous romourac, are commerca avaae.arous moease s- on aeraonsnerase-arn secc. s can asoeeecease o aennea can resuro or exame,oxannes a moeorm aen,, r meamnaon ans rean seuencn as a.ee, e.., caer, “uaoonw,n,eaenr,o amnes,encom.,naoonn.”e ons,nc.,ewor,..,, nn srocmen emaomurenns, mee,omssccoaseon,erena coors,arcoes one or more ses oare reons o , suc mrse a se o caurn an suae aroacnownne ar as c .aure maeerorme usn e oe caure w .n some emomens, caurnncues conacn maave an oeeaures ae ssecr oeareere-sneocr secsr ooeasr.e-es seec ocarroee-ss,enccroes nomeone emomens seor aove ane secons rean cunu aurn maeerorme on one or more susame oroeseow. eren.n some emomens, s c sreareurn meosscose susame, e.., aurerom aeasers susame ore secon susame uner aoesea as seaerarosn s suesame..,e s aenaraen secon o srusnaame.ncuerneeerrss ttorneoceto.: n seuace,o caaseuren.. m,amereormorme o nno a onr, annawncuners nuceoase, suc asm- rs nuceoasee..,m,e no ornoa, or anc oue ornancune secon susame.n some emomens,e s ners nuceoase, ane escreeren anenooeeore usames areerenaaee.., as nucec ac re czaaounr,n w sce mena u eraeneer eroo ernmne ca o s uosu mnre. e e cxonen oonnse sauuaeor secc suc asen,ase comoson, ec.ose sene ar wea res oeroes cononsveneneranoweene ar rearn nuce mar w arorae emomens, comexes oare-seccroes c ac rzaon.n some oanerom ane ssom sue eemcoor amenursa, a m oe seos oe asn acrree ree ar ore nesnorm .nce eu. arese caurn c eenecare reons, wc ma sowerencesn me reons comrse ramenaonaernseenn on weere ornaeromaoneves anor ces.eare reons aso comrse seuence- aumor orromea erencesn seuenceeenn on w varaeare reons, wc ma sow ces.e caurn serouces eere ornaerom aumor orromea moecues corresonnoe se a caure se o c moecues, ane c caureen uence-varaeare reon se are caure a areaer e eenece caure se o c moecuesan c moecues corresonno an are reon se.or aonascusson o caurn ses, caurees, ur roeseas.e asecs, see , wcsncororaeeren reerenceor a o seacnecrroomes an s s ceosm on seu em ureeco wmen o ca as, u sre a m e c oeaore co-e rssc reer sce once nrore oens,n wcu e seerees uen con ncea scen o care- reon se a areaer caureean c corresonno e-varaeare se. e eenecare reonare reon se a can areeaeenre cacaureo ceaurean c c co crorrersonnoe seuence-varae reon seecause areaere o seuencn esonnoe eenecare varaeare reons w suc mae necessaro anazee seuence- e eenecare reons.ee vno cuomne oencaea o nre aecceuracoeaenrm maneera nemceesnsaarono aanaerznes ttorneoceto.: ae.un.,aonceese.so.,rnerurerameon oaeran asncronom sear saees oraronsnsn ses orramen voume oaa neeeoeermneeresence or asenc eneraessane muaons.aurneare reon ses aere e o cancer-reae seuenceare reonsoerenes o seuencnne sanes canacae seuencne mxure anorne same seuencn me seuencn rune.., usn aooe c , e..,on vaerreonus eemreoesm oe snes, ce uene. c mneoesuorrere c eomernsee sce anuen scenuencee- cvaaureare reon ses, conssen wescussoneren.n some emome raeare-seccroes an are searaerom noounoarns, comexes o or exame, wereare-seccroes areoun cova e-seccroes. suor, a wasn or asraon se cane useo s en or noncovaeno a so weree comexesave cromaor earae unoun maera.ernave, wereeroes comrse aa acroeressncrom unoun maerae.., e use. nans a cromaorac resn, cromaora can comrse auras oscu sseses sunea esewereeren,e se oare-seccroes ma or an een c asroesor a seuence-varaeare reon se anroes weecare reon se.n some suc emomens,e caurn seserormeare reoron seesnoree sa smeeu venescsee-v aaraee samareem ree, eo.n., see anroeesororees seoruenec eenec an eenecare reon ses arene same comoson.s aroe-varae reave sreamne worow.n some emomens,e conce acroves a seuence-varaeare reon sesreaerae c nraon oeroesore eenecare re oncenraon oeroesore reonroe sener anoan rv s see. ve,ssee caurn seserorme we seuence-varaeare vesse, ore conacn se an we eenecare reonroe sen a secon a arsme an ars serorme we seuence-varaeare reonroe se or aerers vesse ane eenecare reonroe se a a seconmeeore comoson me.s aroac aowsorrearaon o searaers an secon se an csncun caure corresonnoe seuence-varaeare reon eroceasseure searae cor arseseosnreneo..,eo eraecneoncaaereas ree oonn s mee.ea coomn aosseosncrs caen ttorneoceto.: ersoecwesserne aenre ann an recomnen aroraerooronsorove maeraorurer amcaonsna e sros oms rme su e ecm a eos se oremeunen esc c,n. auern se.sn ame.n some emomens, erorme aere caurn se. some emomens, amcaons co n some emomens, aaers arencuene .s maeone anrcmurerer,n e.. w, as aensc arme acaovoen.roceernaurev,e e.,.,rovne aaersn a’oron o suc asaon. aaers cane ae oer aroaces, e n some emomens,as, wc mae orncuearcoes, arencuen arcoes c.anaes u csaenoac aoaweee onrncaeo.n., o sueec or wennc oe ae nucec c ac.or exame, oownoon o aura o samesorarae seuen ameoeene concurren w an amcaonroceure, e. cn.s maeone o armer, e.., asescr .,rovnearcoesn a’oron r e aove.n some emomens, aaers anasarcoes are aoavere an’e o sameearrmee-r orrrmzenr seo.roorn e oxamee,rmeer.arcoere maeocae’ oe ae oer aroaces, suc asaon, nave,arcoes cane aon susrae. oonaoeer w aaersne same e “eneraeaureson oaeease reoasr” snec amonecoaw,on w,acs, c aannea crcoomesn aereoscues esexn raccae w an oeoreon emomens ane emomens se ennroucon an summar secon. orne resecoesna c soosmur eee emeomens, a caure se o e.., c srove. a caur meos,e caure se o maerove, e..,erormn cornres soen anero a a saerueonncen-va srea aesaerscer reeoner seen.e caure se ma comrse a comnaonereo.n som , an eenecare reon se, or reon e emomenseuan o caure seuence-varaeare normazeorsreeaerereannceenuean sze o oeea craeuere re eonesneocoarrne s rezeo.n , wen ttorneoceto.: resecve,erna corvrees,onrsn ano s aeco senue cnaceu-vreara sees maraee reroonv see,ncun, corresonno an eenecare reon se.ers an secon caure se an comneorove a comne cau s mae e seuence-vanra someea ermeo remoenn ssenre an w sec. e e a caure sencun corresonno caure se asscusse aove,e c enecare reon sencues a comne se maeresen a areae orresonnoe seuence-varaeare reonare reon se, e.., a.r concenraonane corresonnoe eenec concenraon, a.- o.-oreaer concenraon, a.-o.-oreaer a.- o.-oreaer concenraon, a.-o.-oreaer concenraon, oreoae.r- cooncenreraaeorn co ance.n-raoon.,- ao.-roeae.r- cooncenreraaeron co,n acen.-raoon, a.-o.- concenraon, a.-o.-oreaer concenraon, a.-o .-oreaer a.-o., a.-o.-oreaer concenrao .-oreaer concenraon, .-o.-oreaer concenrao n, a.-o.-oreaer concenraon, a reaer concenrao n, a.-o.-oreaer concenraon, a.-o.-oo.-oreaer cno,n acen.r-aoon,. a-no.-reoae.r,- ao.-reoae.r- cooncenreraaeorn c,o anncen.r-aoon,. a.- reaer concenraon, a.-o.-oreaer concenraon,.-o.- -o concenraon, a-o-oreaer concenraon, an-o-ore oreaer -o-oreaer concenraon, a-o-oreaer co aer concenraon a reaer concenraon, a-o-oreaer concen ncenraon, a-o-o concenraon, a-o-oreaer concenraon raon, a-o-oreaer -o-oreaer concenraon, a- , an-o-oreaer concenraon, a reaer concenraon, a-o-oor-oreaer concenraon, a-o-o concenraon, a-o-oreaer eaer concenraon, a-o-oreaer -o-oreaer conc concenraon, a-o-oreaer concenraon, a reaer concenra enraon, a-o-oreaer concenraon, a-o-o concenraon, aon, a-o-oreaer concenraon, a-o-oreaer eer -o-oreaer concenraon, or a-o-oreaer concenraon. eareee re oons,e arsencsecunss ceoncnenreaoensn accoonu snecsoonr. normazaonoreoorn szes o enecareeone ttorneoceto.: reonseoe eereenneaecare rreomon ne soea msac ceo.m.,rusmeo orne o or morees oare ea ces, e.., non-neoasc crcuan r cancer ces anrom scusseneaeren.e een ces.xemar es o suc reons are conro reons, e.., asescreereen.cnar soeme re emono seme mnas, aseo e comenersce oanree or re more semas aoorn o aeas , e.. on so , aeas , aeas , or aeas .n , ee emomens,e eenecare reon seas aoornne rane o- ,..,--, an,--, ,.- ,- ,- ,- ,- ermeaonn s voe amrm raee eemaoa remon reensa o,ra ns.en eea ener enree a,cearo erens me reoan soen vnarcaues one or more reero reons were anncreaseneeve o oser eare reons same,ncaes anncreaseeooa a save meaon, e..,n a c rouce neoasc ces, suc asumor or c mee.., o c conans romoers oumor sure ancer ces.or exame,ermeaon o enom ssorenesaseen oserve reeae.ee, e..,an e a., varaeearoe. re:ons cann acnu ree reerenocness caeoe nroen n.ecnes asnar exameer,n meermeaoaon cancerousssue reaveo romea ssue oe samee,uoenn meaone..,ave more meaon reaveo c ascanea suercsn ere,or exame,eresence o a cancer resusnncreas . o ces oessuee corresonnoe canc e ceea suc as aooss ar usn suc ermeaon er, suc a cancer caneeece aeasn ermeaon varaeare varaeare reons.n some emomens, c moecuesnose reons reo noonsnceurne m onee ora moonre saeenonm cacnc reer sounse,c ws reereavee co cnroosme reeaons ssuneccsa,veu o aearresecnucaerncsrseuaeseeuaen.., ca oncer oerrmne anae resene as c wncrease aoosse..umor senno crcuao s ermeaonare reons mae n. eno oane, e..,romeancer roamesca mse.oan ca ee a.,anceernoomceaor uoson:ermea,oneascrree re coonnssrurcomonr oeas a, ttorneoceto.: coeo sn,ecnce,ov oenre, a onr munore.n soemse o em caoncemens,eermeaonare reons can ermeaonare reonsncue or.ccorn,n some emomens,e ermeaonare reonsa coene,wo,ree,our, orve suses o our, orve oreas, coo cve sowermeaonn one,wo,ree, n some emno,mneen,s,veer, arnoesunor canec eers. roes seccor one or more erme enecare reon se comrse ermeaon varaeare reons mae anaon varaeare reons.e some emomens,eroes sec oose seor aove.or exame,n roes seccor aura corermeaon varaeare reons comrse ,,,, or o oocesoecnseaen,a e.e., a.nea ssom,,,,, seccorermeaon varaeare reons com e emomens,eroes oocsenae, e.., aeas ,,,r,sero,es s,ecc,or a,ura oeocsenae.n some emo , or ermeao mens,eroes seccornae on varaeare reons comrseroes seccor aura oocse oeocrseaen, ea..e, a oerasae,.n s,ome, e,,,,,, orare reon,ere mae one or momens,or eacocusncue as aranscron sar se ane s moreroes w arzaon seanseweene sce oeene.n s o cooneas so coonorenesa are aernave seoson, e.., wonme emomens,e one or moreroesn wn oe se overaneosons or .n some emomens, aroeas arzaon ermeaonare re e aove.n some emomens,eroes seccore oermeaonare reonsonnscuae coroecesv seec scowor onee,rmweo,raeeo,nounr o,n oer,vweo s,usreees our, orve oreas, coon,n , ome e,ver, anun cancers. cancers.ee, e.o.,aon eoma aeon .,eaar noomna ese e aa s. crome :moenon - osservereenaomenonn varous enomcs:- revew arce non oservaons os coanmceerrc, coon, ovaran,rosae,euema,eaoceuar, an cer aonn suc as reeae eemens, e. vca cancers.or exame, reons ercenromercanem reea.s,, an sae eemeens,, aun eenmeernesn, ccen reroomnesrcaan areem or renaeras, ttorneoceto.: m emeoameenns,eae e ceenes mcaar seo rwe reonuc see mnceuesaonnumor ces.ccorn,n some were aecreaseneeve o oserv omeaon varaeare reons, samee.., o c conans er moeuaonncaes anncreaseeooa a ces.n an exame,o ce neoasc ces, suc asumor or cancer necessar e meaon varaeare reons canncue reonsao no oe sa rn meaon saen cancerousssue reaveo romea ssuescameneae,u suoern meaone.., areess meae reaveo c a ceea suc as aooescss o. ceesre o,ore exsasmuee,ee corrreessenocne on a coancee cra rnecseusnncrease caneeece aeasnar usn suc omeaon vara r, suc a cancer emomens,omeaon varaeare reonsnc eare reons.n some weree c moecuesnose reon ue one or moreenomc reons, suecs reaveo c romea susecos noern meaon saen cancer omeae c nose reonssncav,e oueresencencreaseuan o orn ansresene as c wncreas aarcuarssueee.., cancer crcuaon. e aoosse..umor senno reeae eemenns a snomoer enmeroenmce rnes,oomeaon varaeare reonsncue one,cewnor,omererec,o ns.n some emomens, reeae eemensncue er ur, orve o eemens,u eemens, cenromercanem reeas, xaenmemar reea sse,c ancor saeneomec r. omeaonncue nuceoes -eon ansa sow- cancer-a ossocae cromosome.n some emomens,eomeaon varaeare r uman comrse one or eons overa or n soom oe emesoe remeonns. roes seccor one s,eroesore eenecare reon se comrse varaeare re or moreomeaon varaeare reons.eomeaon or one or moreoonms meaaeo ann va oraoesea sreeo rero ansov mea.onrc euxaemroe,eseorro reeso snse scuc as reeae eemens, e.., eemens,u eemens, cenromerc c ercenromercanem reeas, an saee , annere anem reeas, meaenea ces ma sow reuce meaonnunc reonsa are ornar n some emomens,roes seccormoomre cesa.on varaeare ttorneoceto.: r eemoonsmnecnus,eroroese sse sceccocr reorea reeea eeem eemens anornerenc reons.n some our, orve o, a eemens,u ensncueroes seccor one,wo,ree,anem reeas eemens, cenromercanem reeas,ercenromerc omeaonxnenmor cua s erae roroe ese ss se.ccorenomc reonsa sow cancer-assocae ouman eccor nuceoes - anor - omeaon vara ceromosome.n some emomens,eroes seccorncun nuceoes are reonsncueroes seccor reons overan or roesoree-cne ananoer o reons- cannc ouman cromosome enomc reons oneresoso reons as we as nuce ueoseoreecn coons an an maeesneo omze cauorseome-awareroese.., coverae anramen sze varaonmace nuceosoase on anass o c seuence comoson.eons useeren can asonc mennaerns an ase on nuceosomeosons an moes.ueue non-oso reons omze a cancer. n some emomens,e e.., ccss oanerom a suecavn oavn an c saonme emomens,e e.., c s oanerom a suec susece avn aumorc.er.n some emomens,e e.., c s oanerom a suec susece oavnn s aomume emomens,e e.., c s oanerom a suec a suecavn neoasao.r.n some emomens,e e.., c s oanerom suec susece oavnn n seoomea emomens,e e.., c s oanerom a oanerom a suecn remssosna.ron some emomens,e e.., c s cemoera, surca res m aumor, cancer, or neoasae..,oown emomens,e cancer,uecmoorn,, o rra neaooans, oar o ar c suosmecneao cnanceerr,eoum.onr, a onr n oeoaeoreon oeun, coon, recum,ne,reas,rosae, orver.n som sa maeumor, or neoasa or susece cancer, e emomens,e cancer, emomens,e cancer,umor, umor, or neoasas oeun.n some coon or r or neoasa or susece cancer,umor, or neoasas oeumor, ore nceouma.sna ssom oe eemroeasm.enns s,omee c eamncoer,muemnosr,, ore n ceaoasa or susece cancer, susece cancer,umor, or neoas ncer,umor, or neoasa or e suec mae auman suec.as oerosae.n an oeoreon emomens, ttorneoceto.: oorn o aenas som.e em, e.o.,m aenes,e seuence-varaeare reonroe seas a , aeas , or aeas a.sn, aeas , aeas , aeas , aeas seas aoor some emomens,e eenecare reonroe ,- ,nn-e ra,ne- o.,--, e,..,-.-,,- ,- ,- ,- reon se comnrs seomreo eems soecmecnso,raerero rees sec acnor-e se.uence-varaeare reaeenes, suc as onsrom aeas,,, or cancer- , , , ,,,,, ,, ,,,,,,, , ,, , , ,., , , , ,, , , an , , , caure .roomvo eeso rsen ores unnc asu o an m cnoama conmauornencunrs an seconouaons o mocaonn areaerroo rse oreerverom w a cosne comrse aor ronane seconouaon.ersouaon ma s m o ars nuceoase ornaresenne w aereasearn oececrs an nuc ae seocoanse n ourcenoaase wreseonu anereeasearronr secc, wereneorm seccs a moe or unmoe nuceoa o aeraon oasearn unmoe nuceoas se,e secon nuceoases a moe or ornaresenneeerenrroomroe aerrsa nounce ooaassee, anarne soremc oce anrs nuceoase nuceoaseavee sameasearn secc.e se e secon eorm oers nuceoase o conouaonoes no comrse secc.n some emomernaresenne w aereasearn emom ns,e cosne mocaons cosne meaon.n some nuceoaseenss, a meorse n ourc uenomoasees a c moosne.e oer ursnm ano se cosne ane secon oosescusseerenneumm econ nuceoase mae an roceurea a ar or w reseco suecners susameo a e oeresc ss ars nuceoasene erenrom a secon nuceoas ars se o one or meu en n somo es rmam e soe eum. enences,aes arnsoeu seacoonnncouueas ao snenucenuceesa a s seeeuceenceroam ttorneoceto.: sseeceerenromro am seceonrs se se o o on see or more seuenceas, ane secon se o seuenceas n some emomeuenceas.e seuenceas ma comrsearcoes. ucosaem.n some emns,ersouaonncuesroecem, suc as conversonroceuresscusseoeremne,n sus,c aesrssuoeu coanvoenrs wonas, sux-ec ceonvoer asnon, oe c soomnveer esmono,men cso,nveersorsn,oua coonnve wrsaosn s,uece coonvreorseocn, or converson.n eamnaon o m anor.n some emomens oe comnaono omoowencues or waserverom w a cosne mocaonn anr,ersouaon e seconouaon anersouaonncuesrs an s eaerrooronan ers nuceoases a moe or unmoe nuceo econ suouaons, an moe or unmoe nuceoaseeren ase,e secon nuceoases a ane secon nuceoas romers nuceoase, aners nuceoase seconouao eavee sameasearn secc.n some emomens,e nuc noes no comrseers nuceoase.n some emomens,ers unmeooasees c ao msone,e o oorn uanmo weere cnosen me,o anee c secoosnne nusce moas oersm a m.on seom or emomens,ers nuceoases a moe or unmoe aenne, ane see nuceoases a moe or unmoe aenne, oona werene moe acon m. ennes onae.n snom soem eem eommoenmse,nse,rse nurcseo nuacseeoe.as.e, a me.o., ae m coose cosnes o ausen ccoaono--aze-ucos--roxmecosnenes arouc anaee. ancues an c .e can. u a, rno e on.e m coamanvae aonns oescereeaureesrenes,cree caeure ma comrse ses,ncun, e.., areaer concenra ren concernn caureare reon senormaz on oe corresonnoe seuence-varae corresonnoe eeneecoaroorn sze asscusse aovean oe caure sencues seuenc re reon se.n some emomens,e oe enera,encuson o seueas, wc mae aeoe asescreeren.n naura occurrn, un enceas resusne moecuesernromer e comaneaoonrm m.aurer comrse aroe seescreeren or ttorneoceto.: seoru eexnacmne,r amerrso, eeac se oe wscrce maerene mrarom co naura occurrn nucec ac moecues. rmers ma comrse a non-naura occurrname.rse a caure moe, an seuencn oem anuaersss oemse,aroccessn oeaorvence caerorme w reseco mecaare raa usn exsn ssems anecnuess eren, aeacarerover ma ecorsenerae eacarerovers.s usenrove careonvuas reero an en,nvua, orrou onvuasnvove or moreooca co n reaono aeas one oereamen orrevenon o one an anorma nons.n aon, as useeren, aooca conon can reero reae ouncon anor srucuren annvuao suc aeree asorouce or c aaracnerozerou ecxee arnae aencaoreneearnuare c oaracee arsnocrsm,a sns., anooro scma coomnsaonn cancaee caervacaeronzerom e axeornoa acna noorrmnenrn oane c oarr macoreersocsu,a sonnss,. anooro smca conon cane aevaonrom aooca normn one or moreouaons.n varomsancae ooca conon canncue one or more moecuarenoe ous exames, a conon ma corresonoenec or eeneceson s.or exame, aooca aooca conon canncue aeas one s.n one or more aona exames, one or morenures, one or more snromes, o one o onre m oro mreoresaseaseess,, o onnee o orr m moorreenseocroenrs, one or moresoae smoms, or oer aca varaons oooca srucu s, uncon onvuas. ona, areamen, as useeren, can reer re anor roceure, roune,evce, anor oernervenona c o a susance, enen orean one or more eecs o aooca can amnsere orerorme w more exames, areamen mancue a sus ononn annvua.n one or susance mancue a comoson o maera,n sceas meaoze envua.e susance maeevereoenvua vauc as aarmaceuca comoson.enecon, asoron, ornaaon.rea a numer o meos, suc asneson, as one or more sureres men ma asoncuescanervenons, suc meannune .n aeas some exames,ereamen canncue aeraeuca aa.nsrucerv ureeeano acn aa.r ceananacuecaaa anaazse no or exanszne s acscoemrsnncou aesr uen-serunceure or ttorneoceto.: sraonvarerzeasor cmoma.rsoer e oxamreee,e uxn.sruacusr,eea maan mnaernnc wue noes mae aeacare noncuere-enenusa are seecaeeeacarce noes are caureoes own menu or va as.aer,e noesncueex enerover, suc as va aro- mancue senences, senenceramens, wor ere aeacarerovera comnaonsereo, an soor s,eers, smos, arevaons, one or more srucure.or exame, aro .n some cases, unsrucureaa maeara s onsurancen coes,ver cou seec annsurancen coerom areene coe. an a unsrucure noesoaa assocae wan anazn unxssrucnure sseamasn orcearo eexvroe aare amoun o comun resourceso enerorme e exsn ssems.acn snoormaona mae reevano anases unsrucureaa anransorme unsr me cases, exsn ssems ma anaze e anass oerevous unsrucureaao a srucureorman oreroacae ssems canenecen as weu acureaa.e anass o unsrucureaa exsn oaneromeacar snaccurae.n scenaros weree unsrucureaas ecausee anass maeeaa,emorance o accurae anaznenormaonsnvuas w reseco o reaeo aeas one oereamen oranoss o a numer o eacareaa ma re ne or moreooca conons.us,naccurae anases o ememseunano snuso oemcanreuaesm,e anrc oecnurvesuas. an comuer-reaaensruconses ,ramewors, ssems,rocesses, meca recors,ncunor examcreeren arereceo anazn eecronc eansurance camsa e, eecronc meca recors,aoraores resus, onvuas.n conraaoervenormaon aou aeas one oeea orreamen accorno one or mso exsn ssems,eansurance camsaas srucurencue coes or oeroreormas an sore a numer oaaaes.eaaaes ma aes oreamens aanumercnormaonncanreamens recevenvuas, ooca con,osaenormaon,anoses onvuas w reseco one or more eacareroons,normaon reaeo vssoeacarerovers,aes o vsso mae useov acecrs,nnormaon, anee.ememenaonsescreeren uoens oourae anazeeansurance camsaaorunres, uoousans, resen.n varouussa enxasm oens,evnsu oas ooru msaonres,nu wnrce osn oe oro musoarnes,o uooca m conons oon rso awres ttorneoceto.: annoromra coounmonrs onveauasnsnu wrancce c onaem osr maoare maooec aanazeoeermneea-reae n varous exames,ememenaonsescr ceonerons areresen. aa w eecronc meca recors,aoraores r en cannerae moecuar moecuaraa mancuenormaonerv esus,eansurance cams.e onvuas.e moecuaraa ma eromssue sames exracerom a numer exracerom a numer onv asoncuenormaonerveromoo sames aa mancueenom uas.n one or moreusrave exames,e moecuar aa mae csaa.urer,n one or more exames,eeansurance cams nnenreaerae waaermneenecnormaonor a numer onvuas. recors,aoraore reosor mae creaea comnes eecronc meca oenvuas.s resus,eansurance camsornvuas we moecuaraa as asso n one or more exames, anener maeeneraeor annvua aa oecnaev wua.oeeansurance camsaa oenvua ane moecuar eneraeaa reosoe moecuaraa aneeansurance camsaa sore one or moreusrave eor mae accesse usn a sneener oenvua.n secure.n varousxames,eeneror annvua mancue an encreaes correso exames,eneraeaa reosor mancue a numer oaa exame, arsnanaaoeren asecs oeaa sore wneaa reosor.orneneraeaa reeo msaeeneraeancues summaraa onvuasncue eneraeanc or, suc asersonanormaon, an a seconaaae mae raaae maueeseana corresonno vssoeacarerovers. ona, a ouraaae maeeenreaencan mecaroceuresroveonvuas an anvuas.urer, a araaeanecannormaon reaeorescrons oanenvuas.uomcsroes ma mncaueeeneraeancues muomcsron o roes, eenecroes, orro aeas one oenomcroes,ranscromc .ns weaa,a aaueresnoc reureeo evenmc neormnro aees. ns oraneroma oan reeoasaora mea mae canuseen voarmoacoa rom one or more aonaaaaesoe rereve.normaon sore eneanaes mae accesseoenerae a numer oerenaasesa mae useo ana enormaon sore eneraeaa reosor.or exame,enormaonaze eneraeaa reosor mae anaze one or more aormsoe sneorraee ttorneoceto.:raeaasmeesn reace avree ora annzen avccuoar onvero a oenreo or o momree scemas.eaases mancae eaases ma asoncae coors onvuasnc w reseco aooca conon. avn a numer o common caracerscs.n va ueneneraeaa reosor an arranenormaonrom a n rous exames,eaases ma consoae reosor.eaases maeumer oerenaa sources,ncuneneraeaanormaona mae oneres anaze w reseco a numer oueresoncae oreamens oooc o aeas one oeacarerovers,aens, orrovers more acc a conons.or exame, one or moreaases mae anazeo resen anuraeaeermne a survva rae onvuasn wc aooca conons evmn a seceenomcroen resonseo recevn a secereamen. recors, emenaonsescreeren marove aaormo eecronc meca as noaooraunornes ex ressuns, sesaemsnsuarancec caams raa an moecuaraaornvuasncu e on eecronc meca recorsansue an amoun o unsrucureaa. eneran an anazn srucureea escrrance camsaaaaseennerae w moecuaraa,ememenaonso exsen seresnem msaaro rvee o mno rerea acvceuraena cccauraracee,r uznasoruncs ouree eenceroraeaan reaon aa. ona,memenaonsescreerenenerae ana nc meca recors enaee anass oeanormaon aounvuasn a conecns raeaaasesa manner. an anonmze reosoraurencueussr maues ane examese o arceaeccuarreeaa,o acecnoerrane anon oneeraeaamemenaons.e arcecure mancue aaaneraon an anas or more eaaneraon an anass ssem ma oanaarom a numer os sasae smo. anneraeeaaromeaa sourcesno anneraeaa reosor. urces eaaneraon an anass ssem ma oanaarom aeansuraonr exame, aa reosor .n varous exames,eaaneraon an anass s ce cams eansurance camsaa reosor mae creae an mananesemere ane n one or more aona exames,eaaneraon an anass sse n enes.nsurance camsaa reosor mae creae an manane am same aneea eevcaesa.neer oaneon or an mo arnea cosms susnem en. comun evce msa maemncuemeen onee or m onoere or s merovreer ttorneoceto.: coemvceus,n onee ovrc meso,r oenea ore m coormeuesnoe cvomcesu, onne oerv mcoes, one or moreao comun comnaonsereo.n ceranmemenaons, aere moe comunevces, or comunevces maememenen asrue comasu ano eron oe one or more aeas aoron oe one or more comunevces manvronmen.or exame, comun arcecure.n scenaros weree comun ssemememenen a couneraon an anass ssem are conuren asruse use comoumemeneaa rocessn oeraons maeerorme concurren mue vrua mn arcecure, exames,eaaneraon an anass ssem mamemeanc mneus.n varousecnues.ememenaon o asr reanec ue comun arcecure an murean resonurcuesesn c raeuseeaaneraon an anass ssem o uzeewer comun eaeoano cnosmurun arcecuresao nomemeneseecnues. rom one or moreeansance camsaa reosor ma sorenormaon oane suscrers oe urance comanesa corresonsonsurance cams mae reoso one or moreeansurance comanes.eeansurance camsaa easer one maaene’ asrranrsee.., sore aenener.eaenener ma emoer, anee. name,as name,ae or, soca secur numer, aress,ncue srucureaaaesa aar sore eeansurance camsaa reosor ma sorne srucureaa ranen one or moreaaaes.e one or moreaaaesnormaon aouea mancue a numer o rows an a numer o coumnsancae comane nsurance cams mae suscrers o one or moreeansurance eacasn reaonoroceures anorreamens receve e suscrersrom eanrseurrovers.eas aoron oe rows an coumns oeaaaes sore encaeaanncoese csa omsaa reosor mancueeansurance coesa ma suscrers oe oneooca conons, anreamens anorroceures oanensurance or moreeansurance comanes.n varous exames,eea reaeo o cnoee osr ma asoncaeanoscroceures oane nvuasa are more exames, a moareooca cononsa maeresennenvuas.n one or resence o aoocanoscroceure marovenormaon useneeecon oeoeermne arore conon.anoscroceure ma asorovenormaon use anoscroceure mssaonn ocu ae oonoe orca mo croenmaonn.nr ooncee ourre ms,o orene ours mraoreve as esxaams, onees, o ar ttorne oceto.: moreaoraor a moecuaraa reeroc oae saur ones re, orane .o onr e a mnore mo aen c caom uasrsn sa aaso ren emsere osor moa, an as moa oe sae on. renaoarm oaonrom onvuas reaeoenomcnormaon,enecnormaon, meaoo a numerranscromcnormaon,ramenomcnormaon,mmu mcnormaon, me aonnormaon, e enomcnormaon, anor ne receornormaon, more exames,eaaneraon an anass roeomcnormaon.n one or ma e creae an manane eren s ensemes. an e moecuaraa reosor eaaneraon an anass ssem an e mon one or more a ona exames, creae an mana ecuaraa reosor ma e eneenom ac snamorem en . enes o envuas. m aon mancae one or more muaons corresonno eween a seuence o uaono aene onvuas ma corresono erences e reerenceenome n muacecnc acues o anoewnn rveeureansce anen oonmee o,r s mucore a rseerenc.ene vnaormoeuss. exeanme oe asn, an muvauoan on r aeaenoen oo anen reevrenucae meanom coer.rens oonne oro m aore aerenceon aermne e reerenceenome mancue aermneenome o annvu na exames, exames, a muaono aene o annvua mancue a.n one or moreurer enes onvuas ma e reaeonserons,eeo a somac muaon.uaonso eerozos,ucaon, am caon,ran ns, sne nuceoe varans,oss o comnaons socaon,usonenes, or one or more moecuaraanere re oo onse. or more usrave exames,enomcnormaon sore envuas.nese souraon mancueenomcroes oumor cesresen w n enec maera, suc a s,eenomcnormaon ma eerverom an anass o same,ncun,u nsoeomxreoonucec ac anor ronucec ac rom a s, exosomes or eer , assue same orumoros, crcuanumor cesnoo sames osomes, orrom crcuan nucec acse.., ce-ree oun envuas. . onn ovuasasresenueoeeraaon oumor cesresennnsvuas ma co ne or more exames, eenomcnormaon oumor ces o re rresono one or moreare reons.ne or more muaonsresen w eecenoomec onneo orrm maoroena sroere reonse m maoencucaareaea rreesoesncoer oumo mr caesenennevraeuasn. ttorneoceto.: r reesaeocnoo o anne a osrs maor oer oareer reaonnoss ocees reeare maeermne one or more muaons w ma oannn onoerm ora moonrer aom onoena or e mxaomn re aesc,ee oeno naamae. anae reraosonor aens ana.sse s onseem more aonaaa reosores ma soreaa reaeo eecronc meca re ornvuasor wcaasresenn aeas one oeeansurance cacmosrs o reosor ore moecuaraa reosor .urer,e one or more aonaaa reosores ma soreaa reaeo aa res aoo reors onvuasor wcaas reoesnorn ae.asn o vnareo ous eexameaes,nsuer oannece or c maomres aaa roenoasaora reos ororees moec muaraa aa reaeoooca conons anorreamensorooca conons. a sore exames,eaaneraon an anass ssem an aeas aoro n one or more aonaaa reosores mae creae an manane erenn oe one or more moreurer exames,eaaneraon an anass ssem a enes.n one or e one or more aonaaa reosores mae creae ann m aeas aoron o en. anane a same ma oannn oonrem oar moonreroumr oenre omr meomreen reaeroennsc,eneoarmaneraon an anass ssem one or more reerencenormaonaa reoso aonaa reosores.e enons, sanars,roocos, voca res ma sorenormaonancues n varous exames, uares, one or more comnaonsereo, anee. reosore enormaon sore e one or more reerencenormaonaa conons.sn ma corresonoooca conons anorreamensorooca reosores on mea or mncoureeuxsraormve. exxamorems,roev onees o nror mmoarez reee nraemnceesnoro crmnaonaa annss nameso man oeru vocauares usenarmac manaecarusneracon soware.n one or more exames,eaanerao men anru an aeas aoron oe one or more reerencenorm n an anass ssem creae an manane eren enes.n one ora moonraa reosores maeneraon an anass ssem an aeas aoron oeuer oer exames,eaanormaonaa reosores mae creae an mana ne or more reerence oeeansureancaea cnaemsraaoan r aeno asnaorss s,seem moec mne uaar o a aa s anam reae osa en orrom. a,ease o onnee ttorneoceto.: o orne m oorre m aore coonmamuanac raeoons noerwesors, ore reerencenormaonaa reosores va an accesseo aeas one accesseoeaaneraon an anass ssem moecuaraa reosor,e on oeeansurance camsaa reosor ,enormaonaa re e or more aonaaa reosores, ore reerence aarom aeas oosores.eaaneraon an anass ssem ma aso oan reosor ,ene oeeansurance camsaa reosor ,e moecuaraa aa r one or more aonaaa reosores, ore reerencenormaonnereaoosn aonres anas vs sa osneem or mo mrea se ocuraen comamaurnomca aone casan onnees o.ne aeaon,nseaa camsaa reosor ,e moecuaraa reosor ,e one or mor urance reosores, ore reerencenormaonaa reosores v e aonaaa acaonrora a one or more cas o an emmananneerraacoen a. ssem.eaaneraon ssenm ana msas ssem mancue aaaneraon aa reosor ane moecuaraa re oanaaromeeansurance cams reosor .eaaneraon ssemo msaor aso ooeneraeeneraeaa aonaaa reosores oeneraeeneraeanaarome one or more exames,eaaneraon ssem mamemen oana reosor .n varous rocessnecnuesoneraeaarome one e or more nauraanuaenoenerae or more aonaaa reosores n onaea or re moosor . moreoenso re exames,eaaneraon ssem maenerae one or reosor anenanavuasaaveaa soreneeansurance camsaa exames,eaaneveaa sorene moecuaraa reosor .n varous one or morea raon ssem maenerae one or moreoensmemenn asunconssouennceraones.e oenea ora mnoereraooenns ssaseem onn moarmamonem seonree o anee oars m oonre oeeansurance camsaa reosor ore moecuaraa reosor .oe exame,enormaon use eaaneraon ssemoeneraenvuaoenr memenn aasuncon mancue a snv eas one o anener o resecvenvuuaass,,ae or oe resecvenvuas, aosa coe oe resecve n one or moraee ousrrav oe exeam reseesc,veenenvuearss o, or ae reenseerc oveen resvecuavse mnavncuuase. ttorneoceto.: ao cromonn oaone oas a neaamse a ooreon re ose acrvse nnamve ouase resecvenvuas an aeas a erenaa reosores ma correson .oensenerae usnaarom smare sore eerenaoe same or smarnormaon ore same or usn aoron o name a reosores.ousrae,oens maeenerae ener oaneros onvuas,ae or, aeas aoron o aosa coe, an reosor .meeansurance camsaa reosor ane moecuaraa aa source eaaneraon ssem maneraeaarom a numer oeren aa oanser aonmazen nuomeenrs oeneraeerenama seomurecnesn. oonre e oxram moree,aseaunacnonesr usn ssem ma oan one or morersoenseneraeromaa sore eaonnsurance camsaa reosor an one or more seconoensen ea e moecuaraa reosor .eaaneraon ssemeraeromaa sore morersoens w resecoe one or more sec ma anazee one oroensa corresononvua secono onoensoeermnenvuars aaneraon ssem maen ens.n one or moreusrave exames,eoens.rsoen ma mac a seconvuarsoensa macnvua secon reso amoun o smar w resneoen weneaa oersoenas aeas a exames, arsoen ma ma coeaa oe seconoen.n one or more aseaa oe seconoenc a seconoen weneaa oersoense same aanumerc srn .ousrae, arsoen ma mac a seconoen wen an e oerersoense same as an aanumerc srn oe seconoen. camsaa re mnn arsoenenerae usnaa sore eeansurance e moecosor a corresonso a seconoenenerae usnaa sore avnauaaraaas r seosor ,eaaneraon ssem maen annvua moecuaraa reorenoeeansurance camsaa reosor anne romeeansousranocr .ns wa,eaaneraon ssem ma oanaa rome moecuarae camsaa reosor rom a numer onvuas anaa eansurance a reosor rome same numer onvuas an soreeneraeaa re camsaa ane moecuaraaore numer onvuasne more aonaaeos a rao ear osneorr. eason s wsemaaro mma aesoeanenrsaureancaea c saomresaa reeo osneo orr ttorneoceto.: us arnae,ee moaeacunaerraaaon re sossemor mao oenaerna oenee orn meorraeaa reosor .o aa sore an aonaaa reosor , suc as aearoenseneraerom corresonnoaoo reors.eaaneraon ssea reosor sornaa moreroens w resecoersoenseneraem ma anazee one or eansurance camsaa reosor ane seco usnnormaon sore e sore e moecuaraa reosor oe noensenerae usnnormaononvuasrsoens annvua ermne resecveroensa correson eaaneraon s seconoens.n one or moreusrave exames, uncons an a cosem maen roensenerae usn one or moreas reosor ,em mmon se onormaon oaneromeeansurance camsaa eoeremcunanra aa reroosor , ane aonaaa reosor . reosor a corresonso aenenerae usnaa sore an aonaaansurance camsaa reosor arsoenenerae usnaa sore eea moecuaraa reosor ,en a seconoenenerae usnaa sore e avnaaas soreneeaanasurnanecraon ssem maen annvua reosor, ann an aonaaa r e camsaa reosor,e moecuaraa ma oanaaromeeansueraonsor.ns wa,eaaneraon ssemnvuas anaarome moecua ce camsaa reosor rom a numer o rome same numer onvruaasa reosor an an aonaaa reosor moecuaraa, ane aonaa an soreeeansurance camsaa,e reosor . aore numer onvuasneneraeaanvuas maee acaceass soree usn reesenceveraeeaa reosor ore numer o ssem mamemen a numer oecnuensers onvuas.eaaneraon reseco sorn an rerevnnorm asar o ae-encaonrocess w .eeners onvuas ma caorron onvuasneneraeaa reosor asuncon.eeners oe esonoesa areenerae usn aeas one or more sanrocesses w nvuas ma asoeenerae memenn one eoensener resecoeesenerae usne aeas oneasuncon. oan ae usn one or moreasuncons an a common se onormaon , aenorormee aeaonansuaraanc ree coasmosraa r.enos onoer or m,oree muosercauavre eaxaam reoess,ore ttorneoceto.:nenvuerassenaerase soreeaaenneeraraoen ssaeam reosoor accessnormaonor resecvenvua.n one or more exames,eeners oen mae unueor eac aeas aoron oenormaon useoenera vuas maeenerae usn one or more aona exames,een eeoens reaeoenvuas.n erennormaonromenormaoers oenvuas maeenerae usnnvuas. n useoeneraeeoens reaeoe rom a numeera oaneerreanon co smsenmao ma asoeneraeeneraeaa reosor exame,eaanerao ns oaa reosoresn a smar manner.or eeansurann ssem ma oanoenseneraeromnormaon sorenormaon sor ce camsaa reosor an aonaoenseneraerom maeermnee one or more aonaaa sores.eaaneraon ssem cam nvuaoenseneraeromnormaon sore eeansurancenorsaa reosor a corresononvua aonaoenseneraerom enermaaeo uns snoreaa soree one or meoerea ansuornaancea caa remsosaoar reesos.oreerman conrroenso aonaoensenerae usnaa sore an aonaaa reosor esonneraon ssem maennvu ,eaansur asavnaaas sorenoeea aaanncee camsaa reosor anne aonaaa reosor .ns wa,e roraon ssem ma oanaaromeeansurance camsaa reosor same nm a numer onvuas anaarome aonaaa reosor rome oumer onvuas an soreeeansurance camsaa ane aonaaa ara aen num see m ar on aonvauaaas snoreeneraeenearaa reosor.eeansurance camsnvua eaa reosor ore numer o ne on aecc oerss more usn resecveeners onvuas.oenseneraerom eurer exames,eaaneraon ssem ma oan eneraeromn normaon sore e moecuaraa reosor anoensneraon sseormaon sore one or more aonaaa sores.eaa e moec m maeermnenvuaoenseneraeromnormaon sore romnuaraa reosor a corresononvua aonaoenseneraeoensoernmeraaeon u ssonreaa seo orene or moere m aoecuoanraaaaa re reoossoorres.a corereesrmonnno ttorneoceto.: aneroanaon sosenemsener maae uesnnanav sorueasav ann aaaonaasa saor reeonsor ,eaa aa reosor anne aonaaa reosor .ns wa,eoaae moecuar ssem ma oanaarome moecuaraa reosor rom a nnumeraonnnvvuuaass a ann soareareo mmoeceu aaraoan aanaea a reosonoaraaorrome nuem searm oe nnumveerr o ua oneeraneeraaae reaosa roerosorore. nume mero oe sn cunarvauaa asn mae ae acceosnsaea usan so rreesee eners onv cveo one or more reu euaa aas o s. roreramewoernsearaeroeaca reeosrovrac an mae sore accorn meca recors,eanormaon, annsuran ensuree secur o aa mae sore eneraeaa recenormaon onvuas.or exame, overnmena reuaorram osor n accorance w one or more eansuran eworsreceoroecnersonanormaon, suc ase roeconeuceaoonra a.neccnouenraa c anoreeneraaa anonmze ane-ene manneroeaa reosor aso soresaan an aveaa sore eneraeaa ensureroecon oervac onvuasanvuasaaveaa sore en reeorsor .ourer ensureervac o ssem ma re-eneraeeneraeaaeaa reosor ,eaaneraon aaneraon ssem ma creaeena reosor eroca.or exame,e one or more aona exam eraeaa reosor onceeruarer.n aa reosor on a moes,eaaneraon ssem maeneraeenerae enerane n ass, on a weeass, or once everwo wees. re-neraeaaneraeaa reosor on aerocass an no sm reresne enances reosor wen newaas avaae,eneraeaa reosor as,nr svacroecon w resecoaa sore eneraeaa reosor . os uaons wereaa reosores are rerese sm w newaa, mae aaseo more easracnvuas assocae waaaaseen new aeo a an r aeno exssorn necuamuseer oe nnumveru oas newan arevauasav aeeaa a s aorevenmeesaa recaos somaer sse va ana vaaraosues m eaxnaamemese,na sas seomr r. acce e.n aeonn,eraeenearaae reoasaor reoso mrae ttorneoceto.: mnaer saoereaaaa r aeccoosronro on mea or s mororeaaase moes.n one or more exames,eecnooes.or e eaa accorno one or more reaonaaaase reaonaa xame,eneraeaa reosor ma soreaa accorno a ma soraeasaea m aocceor.nn onoe a onr m ooreec a-orenonea eaxaamasees m,oeen.enr oanee oaa reosor exames,eneraeaa reosor ma soreaa acco r moreureranuae aaase moe.n s aona exames,rno an exense maru ma soreaa accorno a srucureuera eneraeaa reosor urer exames,eneraeaa reosor manuae aaase moe.n s moe. soreaa accorno anmaeaaase eneran a nuemaear onearaaaone sss anem cr maeneraeeneraeaa reosorncaeoca counseweeneaeannseweeneaaaes.ens ma eneraeeaaaes exracn seceaaes.eaaneraon ssem ma eaa reosores,,, an so ses oaaromenormaon oanerom aaaes.n varous exa rneaan rows an coumns o resecve one o a one-o-onen wmerees a, roewo ocnao cromuaonnsne onweeeanaaaaea coersr mesaonncsuoe a aeasnormaonn anoeraaae, a one-o-mann were a row o row oae corresonso mue rows onormaonn a normaonn oneaa were mue rows onormaon noeraaae, or a man-o-mannnormaonn anoeraaae o oneaaae corresono mue rows o scem e numer o.aaaes mae arrane accorno aaa reosor rsa.neusrave exame oure,eaa reosor scema ncues a aaaaaaaee, a. seconoaaae, araaae, aouraaae, ann aonamemenaoueusrave exame ourencuesveaaaes, eweraaae ns,eaa reosor scema mancue moreaaaes oraes,,s.,ea,a reosor scema ma asoncuenseweeneaancaeanormaon rere.veeronseweeneaaaes,,,, man aonanormaon sore onme o orn me oeaaaes,,,, resusoe rereve. ona, no aeaaorae aeson,aa,aa,es,,,,, eac oe oeraaaes,,,,,.neusrave ex maamee oneuroe ttorneoceto.: an,eersrsaaaaaaeessoocaca co cuoueeooe seecoounraaaaaaee a ar sseconnn r.nn ao ann,e seconaaae soca coueoeraaae va a ourn .ureero,urearaaaae soca coueoe aaae va a va a n ae soca coueoe aaae reosor scemna v.aro,u as exames, asaaaes are aeo anor removeromeaa reeaa reosor scemaona.nn osnee owre menoreaauasreas mvea exaem aees,oe orn reemoraveeroama orosono oren mav suoaresoara waces aeccoaranneoraeona sas reemosor o scaenmea or aeas a a comnaon o aeaswo oeeansurance ca normaonrom aa reosor ,e one or more a msaa reosor ,e moecuar reerencenorm onaaa reosores, ane one or more so aonaa reosores.s a resu,eneraeaa reosor ma reroes reosre sccveemansanceosr oouseanas,aeanse osou,sans,, u,oun,res a occorounoeaanvuas. sans or more ssem.eeaaaaenenera ssonem an an maassnc suseem a num mea asoncue aaaene scrs, macros, or oerune r o aorms, soware coe, s s o comuer-execuaensruconsarocessnormaon aoraeses maennceureaenormaaa roeno osaorneromo oneene orra meo are ooneaaaaases.e aona ,.e aonaaases ma asoncuenormaonasaeersv,,, oanerom one or more oeaaaes,,,,.e comeoromaa aaene ssem memeneoenerae ars aonaaas nens oe rome comonens oeaaene ssem useoenere maeeren aase. ae a secon aona ancaesna ornmea ocr mroeraem exeanms reesc,eaaene ssem maenerae aaase usrave exames eve a numer onvuas.n one or more one oe ,eaaene ssem ma anazenormaon soren aeas corresonnaoaaaremsaceu,car,eame,ns re,ceveo ae neurmmneer oeanvnsuuarasn.cee coaeas ttorneoceto.:reaemneen sss wem rese mcao a anazraere oeaaanasurnanccea ceos sese ccorreesonarmnoarmaceuca a corresono one or moreeansurance coesoe aceucareamensreamensaaveeen receve envuas.nermne names oarmaceuca aaene ssem ma anazenormaon sor one or more aona exames,eoeermne mecaroceures receve a numeer oneneraeaa reosor ene ssem ma anazenormaon sore one oveuaas.aaousrae,eaa , oeermnereamens receve nvuas va aeas onees on,ec,on or,nnroarvmeanoouns s.orne one ore monreeruareer eaxaam reoess,eaaene ssem ma anazenvu or oeermne esoes o careor meo nas,nes oera receve nvuas,roresson o aooca conon, or maexereamen.n varous exames,eaasesenerae eaaene ssem maeneraeerenorerenooca conons.or exame,eaaene ssem cancer, a ars numer oaases w reseco arse o cancer, suc asun coorecan can ac seerc.on numer oaases w reseco a secone o cancer, suc aso assnonormeaaoan asseocnae ses wemn mvau aassoaevenrmnaea o sneor oer more ceonneernaceeevaeas r aeosor .e resecve conenceeves ma corresonoeren measure rccuracornormaon assocae wnvuasavnaa sore eneraesa oa ceororsor .enormaon assocae w e resecve conenceeves maneersaoenaoa o reneos oro mrore c.araacueesr os ccosn oenncevevueassoerrvee onero omr moarae c soarreacersce maeenerae eaaene ssem n con s aas uncon weneran one or moreeesromeneraeaa reosor .n one or more exames, ars conence covreres moan corore as soencono a ranrse r oan mee oasu mreeassu ores ac ocu aracccu,ra acn, a secon conenceeve ma corresono ar rane o measures o accurac.n ar conenceeve ma secon rane o measures o accurac m one or more aona exames,e o measures o accurac a ancue vauesa areess vaues oers rane areessan vaue ner rane o measures o accurac mancue vauesa exames,normaso on coerr seescoonn rnanoe oe mersasu croens oe anccceureavce. mna onee o rer merorereou assraove ttorneoceto.: s reaenrraerono arsmavoenr, snaonrmaraonno cromrraesoonn, annonorem secon conenceeve mae conenceeve mae reerreo asronze sana aon corresonnoer c eaaene ssem maeerrmnneor vmaaueosn.ore conenceeves onaorramcaerosnc msa oen usveuaoseaesremn oen c aa nruamcerers ocsa oconrs.voura exs.amee,a aa resecve se o maeermnee conenceeves o caracerscs onvuasaseene ssem o comeeness oe resecve se onormaon useoeermn on an amounnvua.n suaons were one or moreeces on e a caracerscor annormaon assocae w ars numer onvorumaon are mssnrome se o caracersc maeoweranor a secon nu as,e conenceevesor a mssnrome se onormaon.n onem oer onvuas werenormaons nonormaon mae use eaaene ssre more exames, an amoun o mssn caracerscs onvuas.ousrae, arem oeermne conenceeves o eermne a caracersc o annvua aer amoun o mssnnormaon useooeowerann suaons we ma cause conenceevesore caracersc caracerscsower. ree amoun o mssnnormaon useoeermnee conenceeves urer,erenes onormaon ma corresono varousnormaon useoore ae crmarancee ar csacr.acne ornsec or o m aonren exavmuaes, mae reresusencne c oon aresncece o ore caracerscen eraneresence o a seconece onormeeves eermnee caracersc aon useo eermne a numne orn oe onrv m.oureasnucsuraeven e axa cmoores w,e aarmaareane ssem ma or oerooca conon.eaaene ssem maeermnneo css oun cancer or resecvenvuas w resecoen casse asavn armonenceeves cancer.eaaene ssem ma usenormaonrom a numearanoss ounneaaaes,, , oeermne a conenceever oo crouemnnscuncuenvuas wn aun cancer coor.e numer o coumns mancueeanson o coes reaeoanoss oooca conons anorreamens ooo surance ona,e numer o coumns ma corresonoaes oanoss aca conons. orooca conons.eaaene ssem maeermnea a cnonorenreamen o annvuaen caracerze asenar oeun cancer coorsceeerven ttorneoceto.: screensaroos n wumereern oo crmoaumonnssa anvananseanocres eac oe numer o coumns or aeas a reso numer o coumns.ure werenormaons avaaeoressan aevesornvuasncuen aru,neaaene ssem maeermne conence avaa onormaon assoca cancer coorase onee onormaon an were one or morea e w one or more coumns.ousrae,n suaons rou noss coes areresenn reaono one or moreeros omeor a m onvuas an one or morereamen coes are asen,eaaene ssem coaoresermrenaeeraanen co snuaenocnes weveer oe anceuasn one oeroeu oannosvs couaessns aeseunn cancerreamen coes useoeermne weernvuas arencueneun ca ane areresen. ncer coor .eaa anaesasa snseemraon a mna an raecesvse snseemrae maaa rnecouseo ara rea anass ssem one or more comunevces, suc as an exame comunev uess romneraeaa reosor reuess ma causeaaoe re ce.e one or more reosor .n varous exames,e one or more reveromeneraeaa ma causeaaoe rereverom one or m neraeaa reosor reuess .eneraeaa reosor reuessoreaasesenerae eaaene ssemneraeaa reosor anore one or m mao seceaaoe rereverome ssem.n one or more aona exames,reeaasesenerae eaaene mancue one or morereuueresa co neraeaa reosor reuess a rereve a sece se oaa rresono comuer-execuaensrucons aasesenerae eaaeromeneraeaa reosor anor one or more a n resonseo one onre m sosreemnera.eaa reosor reuess,e rena aossosr ssem or one m ora mo arneaazaeseasae rneerraeveerome aaaease onnee s osemeneoraea eneraa aae evac aensa, suscs r aessu exasme. comeuaan anaevscse resu.sou maee seunsrao ovnee e oxram moree o comuuren sow m asnaeea oane an oar msorse rensuesraeaean re seonsoor a rneoueesrs comuronm oneev ccoemu,nn oenvec oer coomreu anoenvacemaem seennaeon osn,e oer maorae annaersase resuaas reos moar ree rueecsesve. ae samaea ttorneoceto.: aneavcses resu orse co maesae one or more userneraces renere e comun n onme oru mnoree evxacmees. one o one or more macneearnn,eaa anass ssem mamemen aeas aa rereven reso ecnues or one or more sascaecnueso anaze more exam nseo one or moreneraeaa reosor reuess.n one or neworsoes,eaa anass ssem mamemen one or more arca neura reu anazeaa rereven resonseo one or moreneraeaa reosor moreess.ousrae,eaa anass ssem mamemen aeas one o one or rerev ceonvroomuonean neeurraae newaoar rse oors onoer or morne r reessounase neour oane ne orw moroso anazeaa reosor reuess.n aeas some exames,eaa anassr seneraeaamemen one or more ranomoressecnues, one or more su sem ma one or more enarov moeso anazeaa rere or vecor macnes, orneraeaa reosor reuess.ne or morven resonseo one or morememeneo anazeaa rereven resonseo one sasca moes ma asoe reuess oen aeas one o correaons ore or moreneraeaa reosor caracerscs onvuas.or exame,o measures o sncanceeween resonseo one or moreneraeaa re raness mae aeoaa rereven azars moes maememene w roessor reuess.n aon,oxrooronaneraeaa reosor reues ecoae rereven resonseo one or more aa rereven resonseo ones.urer,coxon sne raness mae aeo exames, a z-score a or moreneraeaa reosor reuess.n s oer one or moren nass maeerorme w resecoaa rereven resonseo eer anass mearaeeeaa reosor reuess.n s aona exames, aaanneraeaa re rorme w resecoaa rereven resonseo one or moreearnne osor reuess.n aeas some exames, one or more macneecnuescon . anaues maememenen comnaon w one or more sasca reuess zeaa rereven resonseo one or moreneraeaa reosor eermne a ran one or moreusrave exames,eaa anass ssem ma or mo e o survva onvuasn wcun cancersresenn resonseo one mraereaemeremnnse. an o ranee o or m suorrve ava oonnavusuarasveav exnam onees, ore moarea aennaomssc s reseomn ttorneoceto.: m exuamaoenss,ne waca anuans csa sncseremsres menane resonseo one or morereamens.n varous wereeaa rereverom aeas o neraeeaa anass resus n suaons moreaasesenerae eaanee oneeneraeaa reosor ore one or exame,eaa anass ssem ma ssem sases one or more crera.or rereven resonseo one or mor eermne weer aeas aoron oeaa conenceeve.n suaoeneraeaa reosor reuess sases areso rereven resonse ns weree conenceeveor aeas aoron oeae reso conenco one or moreneraeaa reosor reuess sessan a oron oaa aeeve,eaa anass ssem ma reranromeneran aeas a oeaa rerenvaessn r reessuosnse.on on scee onrar moosr wenereeraee conaaen receosevoero rre aueesass aoroneas areso conenceeve,eaa anass ssem maenerae aeas as a oeaa anass resus.n varous exames,ereso conenceeoron reaeoee oaa anass resus enenerae eaa anass svese mmae. ann n one or moreusrave exames,eaa anass ssem ma receve rae oe sruarvevaa oa r oeneos oro mro rreeunesvuaso.nenereaseenasaan acneas,sse resauas anassa ssnecae a maeermne weereaa sore ene m mor raeaa reosor anor one or suceaasesenerae eaaene ssem sases areso conenceeve, ssem as ao ma sa rnecaerve co annneneceraeeve.ana o rneeo osr moorre r aeuesona exaomeneesr,aeeaaaa a annass resus ancae areamen rec assm eve one or morenvuas.neseneermaeenaons,eaa anass ssem maeermne weereaa sore e ssee.m saaas reeosor anor one or moreaasesenerae eaaeneev s aowerreso conenceeve, suc as aronze sanar conence ma rec n one or more aonausrave exames,eaa anass ssem moreve anneraeaa reosor reues oeermnenvuasavn one or coneoenn.omonc mnuunao wns ans exaamaev,e reeceavae ana oness or s msoemrerea cmaneneseromrn ae ao suorvca rae onvuas we one or moreenomc muaonsn reaonoe one orvareamens receve envuas.eaa anass ssem canenen masoere ttorneoceto.: ooneneo smurvcv mau raaeon osnavuas an eecveness oreamensorenvuasn reaonnvuas mae maeresennenvuas.ns wa,ea oucomes o orou mrove ennrosecvereamensa mae more eecve enroavoens oonevnuasavn one or moreenomc muaonsan currenreamens oaaaesn anurev neruaseruaaes as. aan re exoamsore,r aamcceowrorno o cnoerr oers moonrenmoe amne arnraanoenms.en eusrave exame oure,eramewor ncues aaa reos n ancues arsaaae, a seconaaae, araaaeor, scemaaeusr,a ave exaamaea oeu,re a sxncua aouraa e eas saeveena,a ana ae sse,vnen aaoanaameem.ou eaa reosor scema mancue moreaaaes ore enaons, reosor scema ma asoncuenseween weraaaes.eaa ,.enseweeneaaaes,,,eaa,a,es,, m,an,ca,e, anormoanaonn reorrmeaveonr somore one o onee ora maorae aeso,naa,aa,es,,,,,, resu,san, ma,eonee reore evace. oona, no aeaaaes,,,,,, usrave exame ouree, oeerrsaaaaaes,,,,,,.neae arsn aneraaaaeessooccaa c cooueoe seconaaae a seconn.e seconaaaes asoocaueoe seconaa aaae arn ,e s coueoeour aa econaaae soca coueoe sxaaaeae aou arnn, an.e seconaaae soca coueoe e sxaaae a sxnn a anone, sxaaaaaaee ssoca coueo e sevenaaae a sevenn.urer,e sevenaoca coueo coueoeouraaae an e n .n varous exaamaees,soca are aeo anor removeromeaa reosor scem asaaaes aaaes mae aeo or removeromeaa r a, aonanseween usrave exames,enera eosor scema.n one or more aa reosor sce eaa reosor ma soreaaaes accornoe ssem oanemanormoar aonearsom a ao cromon onaeonn ov aueaassowr wo oceeeaaannesurraanocne ttorneoceto.: caaam rseoasao rereossor.s, a rees muo,ecuearneaara reeosaoar re, ane one or more aonansances oeaaaes,,,,,,os acocrorn ma sore resecve scema orousans,ens oousans, uounres oo oeaa reosor n one or more exames,ersaaae mausans or morenvuas.oenomcs anenomcsesn, eenomcs an e soreaa corresonn exame,ersaaae mancue coumnenomcsesnornvuas.oro aane useoeneraeenomcsa sancuenormaon corresonn meaon o eenomc re a, muaons oenomc reons, eenomcaa, coveraeaan ons,es o muaons, co numers oenomc reons, or mo can numers o nucec ac moecuesenen a sameavn onencure muaons,esnaes, anaennormaon.ersaaae ma aso one ore m oonree ora monroes cso coumenss.anocnuae,eaennosrmuraanocennaar csoeasaaa mea corresono aeas oneeneror annvuaas assocae w annsance o mancue . ersaaae e seconaaae ma soreaa reaeo one or moreaen v ornmavonua cosrreos oonne onr moo rreeseecavec sa ssn errevcreosvroevrs.eeonrvuaaas wae res ma sore moreaen vsso one or moreeacareroversnca eco one or ousrae, annvua ma vs aeacarerovere an me seconaaae. erorme w resecoenvua ae vs. seconaauae servces mae coumnsncannormaonor eac oe mue servceseroe mancue vs.ueraaaes maeenerae w resecromeeuarnen vesaenncue coumnsncannormaon on a moreranuareveor a res a roveurneaen vsanenormaon sore e secon ecve servceoeaen vs.or exame,e seconaaae mancueaa muaee c reaencan aeansurance coeoreren servcesroveo an oumns aen vs an araaae reaeo one oe servces mannvcuuaeurn a coumnsor aonaeansurance coesa corresono aona mueoe resecve servces.e seconaaae aneraa normaon reae vs mancae one or moreaes o servce correson aes or aaen eouraaae mancue coumnnsoaenaceane vnsor.maon aou ttorneoceto.:nevouruasaoar waceno mrmaanocnuse so coreumnseannercaaeenaoarm reosor.or exame, o aocaon o annvua, aener o annvua, aon reaeo aeas one oea o annvua acae, or one or more aesae or o annvua, aae one or more exames,eouraaae manc assocae wenvua.n weer erroneousaaaseenen ue one or more coumns reaeo ouraaae maeeneraeor annvua.n varous exames, a sne scema mancue muenseor resecvenvuas.us,eaa reosorens oousans, uounr ances oeouraaae, suc asousans,o aeansuraence comaae anas oe oo rove mus rnaan mens nc o aur m eeo n croe.umnas maaenacameennormaon reae servcesroveo resecvenvuas.or exame, or one or more one or moreaereners.e sxaaae meancuaaea ce mancuenormaon corresonnoeansurance coverae oumnsancue n one or more exames,e sxa normaonor resecvenvuas. o meca coveraeor ann aae mancue coumnsncaneresence an ae oeans vua,eresence oarmac coveraeor annvua, oranzaon urancean reaeoenvua, suc asea manenance e s,evreenerreaaroaveer ora mnazaonncue c, anee. reaeoarmaceucareamens oane a roumnsancaenormaon exames,e sevenaaae mancuesecvenvua.n one or morensurance coes corresonno e one or more coumnsncanea eeansuran armaceucareamensa are avaae va aarmac. ona,eece coes ma corresononvuaarmaceucareamens. reseco ansurance coes mancae aanoss o aooca conon w suc as a annvua.e sevenaaae ma asoncue aonanormaon, o res aueasor oznee, oaoessa oe s aemrvoucne,s, or nunmoermr oaona rse’a sueo,ueannvusaen rese, numer armaceucareamen. cevne anass oenn voarrmoauson ex samorees,eeaaaa reaosesor s,cem,a marove resus o more ecen mannerancaaa reosor scemas.,or ex,,, n a conneconseweeneaaaes,,,,,,am aree, arreanoecao ttorneoceto.: ec,en.n re sreuvaeonasa waeres reeaaea aacroessse,e,ren,aa,aes,,,, are a,rran,e, a sera manner anorn suaons were areaer numer oeaaa n ,,, areoca connece, rerevnaaromeneraeesaa, re,, rom one or more oeaaa osor reues es,,,,,, o resonso a suaonsor wneroermaonromeneraeaa reosor weess ecenann uereaa reusorsaeosr an sc arecmaecsmemene. normaon rereverom ure oenerae one or moreaasesrom o sources, a aaa reosoraneraesea reaeaarom a numer aa ccorno one or morememenaons.e arcecure mancuee eanaenraeon an anass ssem aneneraeaa reosor . ona, aneaa arnaaon an anass ssem mancue aeaseaaene ssem onaaarocessnss ssem.eaaene ssem mancue a numer o ses a nsruconsa are execuaeoenerae resecveaasesa mae ozeeneraeeaaaa a annaassss r sesusesm.n resonseo anneraeaa reosor reues seconaaroceessananserucneo snssem, u moancauaerrosaarocessnnsrucons, rocessnnsrucons,, mae execuacessnnsrucons.eaa erorm a numer o oeraonsoen e one or morerocessn unso romeneraeaa re erae resecveaases usnnormaon oane rocessnnsruc osor .n one or moreusrave exames,eaa cas, macro ons,, mancue aeas one o soware coe, scrs, ene s, an soor.ersaarocessnnsrucons mae execuaeo erae arsaase.n aon,e seconaarocessnnsrucons mae mxaecuae eexeocueanereaeo a seenceornaea anase.aausreer,.en varaoausr eoxcaemssnes,n asruconsneraon an anass ssem eneraeseneraeaa reosorereaa ene ssem ma causeeaarocessnnsrucons,, oe, exeeaaoeneraeeaases,,.n one or more exames,eaases,cue mae sore eneraeaa reoso , acc r or an aonaaa reosoras roecsesssneonsruecoanasne,rao,n an ma ana anassz seseeamns.uranceea cso aesooroenne orae aeeaasa ttorneoceto.: ansorruconon ose,aase,s m,a a,naz.eenomonacs,a aaeoase aneroareo an oease aaoaroroncessn aases, oe execuaeo ren, r oenve. e ora maorreom ex oanme oers, moreerrssaaaaaroceesss snorensruceonsner mae reosor .ersaarocessnnsrucons ma asoe execuaeoa reaa aarom one or more sece coumns oe one or morersaaaesereve exames,ersaarocessnnsrucons mae execuaeoe.n varous aave aeansurance coe soren one or more coumn an ronnvuas corresono one or moreanoss coes.ersaaroc w comnaonsa e execuaeo anazee one or moreanoss co essnnsrucons maen or wcenvuasaveeenanose.n one oesoeermne aooca conon aarocessnnsrucons mae execua r moreusrave exames,ers w reseco arar oanoss coe eo anazee one or moreanoss coes corresono resecveanos sancaes one or moreooca cononsa uoousans oanoss cos coes.erar oanoss coes mancueunres execuaeoeermnenvuaes.ersaarocessnnsrucons ma asoenormaon oenvuas, sucs aasnaosee w aooca conon anaznmn one or more comnaonsereo s oreamen,aes oanoss,aes oea, rom one or moree se seccoonnaaaaar,o a ecn ses ssone rense.ruceonnesrae maaae re exoescuoareo. rereev seecaa aarocessnnsrucons ma asoe execuaeo rereveaarom on on sece coumns oe one or more seconaaaes.n varous e e or more rocessnnsrucons mae execuaeoennvxuaamses,e seconaansurance coe soren one or more coumn an row comna aave aea morereamen coes.e one or morerea onsa corresono one or rom aarmac.n one or mo men coes ma corresonoreamens oane corresonorea re aona exames,e one or morereamen coes manravenous. mens receve a mecaroceure, suc as annecon or one or morereamee snecsona caoraresroocnessonen rsesrueccovnesea mansurean ecxee ccouaesencoueeermnne onreee orer mmonree s seecon onaoarmaaoens.e anarezenermneee sae onnsuorramncaeo cno meann rceuaeon aoe a aa ttorneoceto.: oruasransa oneacaesns ounrean ocre m coorees.reaem seecnosa corresono one ou ounres uo e seconaase oncae res naarocessnnsrucons maenerae one or moreusrave e ecvereamens receve arou onvuas.nncuenersaasxames,erou onvuas ma corresonoenvuas w one or more r e.e seconaase mae arranen rows an coumns ereamens receows corresonno a snenvua an one or more coumnsncan e execuaeoeve enerareocee ess rensenc asvraue scn eonvsua. cwomerenn manorem anosveneer ma revouseneraeaases, suc asersaase a aonrom a numer o aon,e rocessnnsrucons mae execuaneoe seconaase.n o rereve aonanormaonrom one or more aonaeneraee aase aa reosor anncororaee aonanormaon croumns oenerae reosor wnormaon oaneromersaase anome seeconeraeaa or exame,e rocessnnsrucons mae execuaeoennanase.ncuenersaase a arean vuas se ose w aooca conon an anaze ece coumns o one or more aonaaaaes oeneraeaa reosor onermneaes oereamensncaene seconaase a corresonoe raoacvesasunas es onnscruu ece noensne rae maars a reea eoxa sesce ourae.on o an o eane erz o mer cno m euomre osnasu e or s o oenre e re ox aram mmoenrees s a,e ncoanane seconaase receve envu e wa,e ro asncuenersaase.ns aasease oncessnnsrucons mae execuaeoenerae an esoes o care n onormaonncuen a cooraase an areamensaase. reosor reuesne o,r meoreaau ansarasvse s exsamemes,n m raesoenesermon reec oenev onr m anorenearaaseaa corresonoeeaures oeuer reaeoeneraeaa reosor r esa exame,eaa anass ssem maeermneanormaonncueeues.or aasseor re anuese s.ecnonesea sacseenaros,se a ners reo aaca anaesos r sessoenmn moae ananezera aeeasaa oronna osse resauasncu.en onne oer mrosre aaaseona e a a aa a xnamees s,ecoenaaa aansaess sosemenerae mae ttorneoceto.: reeeorsmonre reueersenaans oerseroo resenoenraeoeearaen anaueresncueneneraeaa aa ses ma reuece usee o nu smeecr oc snesu osroama userorsce ossnss ean ress aruuncsons.oenerae resecve as we as reucee comuaonaoa, suc a eraon an anass ssem memor, uzeorocessn se amoun orocessn resources an secc arcecure eraeaa reosor reuess.or exame, woue reues s recev oeeaaene ssem, eacme anneraeaa reosor s assemerom,eaa uzeo resonoeneraeaa reosor reues ssem o execueeeaaa reosor .n conras,memenneaaene ,,,eaa neeeaoro rceessnnsrucon,, oeneraeeaases as areaeen asseme sono varousneraeaa reosor reuessoeneraeaa reos an mae accesse eaa anass ssem o reson eneraeaa or reues.us,e comun resources useo resono eneraeeaase rseos,or, reue as memenneaaene ssem o arsn an coecnroce reessanca ssemsaerorm annormaon suaons weree ssor eacneraeaa reosor reues.urer,nneraon an anaaaene ssem as noeenmemene, users oeaa reues n orersos a ssem ma neeo sum mueneraeaa reosor eerecause nazeenormaonae users arenennoave anaze ncae aoc coecon oaao resono anneraeaa reosor reues mue ssemssnaccurae orecauseeaa anass ssem s cae uon u mesoerorm an anass onormaonnca ssemsa maeerormemsnem ae snne.eneraeaa reosor reues weneaaene ssem s a ureusraes an arcecure oenerae anneraeaa reosor ancuese-eneeansurance camsaa ane-eneenomcsaa,ncceorranon aon on aena ors mso sresemmem,eneaoenas.nseur aarncce cecaumresaa r meaosonrcue, aenaa moecuaraa reosor.eaaneraon an anass ssem ma oanaenourmaon rome moecuaraa ennc reosor .eaennormaon ma .eeeneonmomcscsaaaaor mnavnuacsaea rvesnusa oa s oonree or moree m nouceceucar acaa se reuoesnconr ttorneoceto.: oeeranovnsuaas a wnaz rees seecuenoc oense o o nru mcoerec aacr moecuesncuen a same oanerom e same mae oaneroms eenomc reons.n one or more exames, exames,e same sue o one or morenvuas.n one or more aona asma.e one mae oaneromu o one or morenvuas, suc asoo or corr or moreareenomc reons ma corresonoenomc reonsa reoesnso mnao correesorensenocee ono omnec o rer moonrse o ao roeecreanc ceonenoomnes.avorn ex mame,eare resennnvuasn wc aooca cononsresen.n one ouaonsa are exames,eare reons ma corresonoenomc re r moreusraven wc one or more muaons arere ons o a reerenceumanenome areresen.eaen sennnvuasn wc one or moreorms o cancernormaon aounvnormaon ma asoncuenormaonncanersonanormaon corresonnuaos waa sore e moecuaraa reosor annvuas. eesn an anasserorme on samesrove rocess a aneonaamnzeesrearsoonna an anass ssem maerorm ae-encaon .eaaneraon an ananormaon oanerome moecuaraa reosorecnues asar oee-ess ssem mamemen one or more comuaona sore e moecuaraancaonrocesso anonmzeaa reaeonvuas oenvuas ansn c roemosaonrc sucaee-eneaaroecservac e-encaonrocess e w one or morervac reuaonramewors.eoens ma com mancue, a, accessnoens.n varous exames,e maeeneraerse ane aaaanunmeerrac sornn an o a cnaarascse srs.senm one or. mnor oen eex oarm moerse, aeooenns exaamsses sseemoens maeenerae a a an r-ar an oane eaaneraon an suse oee. aoeennsn moarmaeoennera.eo usnus ornaee, oro mronrevasuausncaonsavne renaormonao a sore e moecuaraa reosor ,eoens maeenerae usn a comnon o aeas aoron o ars name oe resecvenvuas, aeas aoron aon name oe resecvenvuas, aeas aoron o aae or oe o reseecas rnesvecuvaes,n avenuaers. oeeen-evnuacsa, aonn aroceeasss ao mraon a oso ancoucaeo,n aen,eenre ove rane ttorneoceto.: eenneerrss moarneveneuraaseaaeveaaaane sorraeon ane an maosecsu sasreaa reosor .e asunconsa areerenrome one or morea m usn one or moreoens.n one or moreusrave exame suncons useoeneraee enerae annermeae vers s,eaaneraon an anass ssem ma en a one or on o resecveeners usn one or moreasuncon an aeneraena vers monosre o saeneencnersu.es soaeunnceormne comaer vseerss aonusn ocone conenureersoo en aeer.asn v oanreo ruasn exoammes,o eeacaanneermreaoane anen anaersso ssenemerae a m raeseecvena eners a usn aeas aoron oenormaonor resecven neraee e moecuaraa reosor .n one or moreusrave exa vuas sore eneraease on aaenenerncueneaennomes,eeners mae enerae eaaneraon an anass ssem marmaeo unnu.eenersnvuasavnaa s eor resecve oeore e moecuaraa reosor . moeaennorrmaaon,eaaneraon an anass ssem maenerae mancueenomcsonaaas re oneeners.e moeaennormaon reosor aneenerse oaeeonvuas assocae we moecuaraanormaon maave aaa srucure r.esecvenvuas.e moeaen ancues resecveeners onvueaa srucure mancue a coumn an a numer o coumnsan as assocae we moecuaraa reosor aseners o one or moreecueenomcsaa reaeoenvuas, suc eenes, an so nes, aeraonsoe one or moreenes,e o aeraonooen eoraa.neraon an anass ssem maenerae aoene.e ave mancuersoens accesse a oeraon or resecvenvuas srucnureaa sore e moecuaraa reosor .eoene maave aaanvu ancues a numer o coumnsancuenormaonor resecve eneas.eaa srucure mancue a coumnncan resecveeners rsraoeense asasoacnaeera won ane r aensaecssv seseemners a.n ceouamansnnercaaonn a onne a onra mosre ssem ma seneoene o aeansurance camsaa manaemen sss as coueoeeansurance camsaa reosor .eeansuranecme ttorneoceto.: c coarrmessonaan m saencaonemeonen sssem.e se mcoan aonaenzsee marseo acens w reseco eeansurance camsaa manaemen ssem. cesse orenerae enerae usn a same or smar suse onorma e seconoens mae eeansurance camsaa reosor aonornvuasavnaa soren .or exame,e seconoens maesenee suse oeaennormaon oron o ars name oe resecvenv rae usn a comnaon o aeas a resecvenvuas, aeas aoro uas, aeas aoron oeas name oe oenvuas, an aeas aon o aae or oe resecvenvuas, aener n varous examesr,on o aocaonener oe resecvenvuas. ma rereveeansur eeansurance camsaa manaemen ssem ornvuas ance camsaaromeeansurance camsaa reosoroens assocae w resecve seconoens a mac corresonnrs as a.easr asroesen ma mac a seconoen weneaa oersoen .n one or more eo amoun o smar w resecoeaa oe seconoen oersoenxsame seasm, arsoen ma mac a seconoen weneaa n resonseoeen asenaaea oens suecraonnceo caenms. resecve seconoens a corresono a rese aaornvuasavnnsurance camsaa manaemen ssem maenecversoen,eea aa.eeansurance camsaa man rae moeeansurance cams eansurance camsaaoeaaneraaeomen ssem ma sene moe exames,e moeeansuranc n an anass ssem.n one or more srucure.eaa srucure e camsaa maeormae accorno aaaoens a corresono mancue a coumnancues a suse oe secon eansurance camsa ersoens an a numer o coumnsancuee enomcsa oeraona.,eaaneraon an anass ssem manerae moecu a aneansurance camsaa onvuasa are commonooeneraaraa reosor aneeansurance camsaa reosor .eaa moecon an anass ssem maeermnenvuasa are commonooe eermunarnaea reosor aneeansurance camsaa reosor eaanernaomonc asna aana ansse sasemnsuranc mea caemesrmanae corares aonrsnoeon comm reonaeoeons a. ttorneoceto.: oearonn osuraenceen coammcssaaaae ceorrmresnonn as moea as suerconoen reaeo aoron oe ane seconoen.n scenaros wereee o smareweenersoen o smar w resecoe seconoen,rseoen as aeas areso amoun ma soree corresonnoron oeen aaneraon an anass ssem oeeansurance camsaan rea omcsaa ane corresonnoron aa reosor, suc aseneraeaaonoeener oenvuan annerae ememenaon oe r aercoseocrure o maurem,eure, anure. roocoa enaese-enenormaonromsaraeaa men a croracno a sneaa reosor.ns wa,e secur oea reosoresoenerae reosor sncrease. ona,e croracar sooorce eneraeaa arcecure ma enae more ecen rereva an accura omemene e eneraeaa reosor ann suaons wee anass onormaon sore arcecure s no uze.or exame,eneraree croracrooco oeoens usn a croracecnuease on a snec aoee sne ancuesrs e moecuaraa reosor an uzn seconoensee onormaon sore smar croracecnue w resecoe smar o nerae usn a same or eeansurance camsaa reosor ,er same se onormaon sore ma macnormaon sore saraeaa raaneraon an anass ssemnvua. oumemenne croraceroosoresa corresono a same roa oncorrec arunnormaonrom onoeco oe arcecure,envuasncreases, wcecreasese a aa reosoro one or more an anass ssem n resonse ccurac o resusrove eaaneraonneraon an anass ssem oneraeaa reosor reuess senoeaa ssem,aureusraes a.ramewor oenerae aaase, aaaeneme se onaa sore anneraeaa reosor, accorno one or more anemneonmacsonsa.aoer aneroruae onaav reuoassor.or m exaam soere,eeanenrsauerancaea c raemossoaa ma sorenormaon oaneromeansurance cams recors oe rnvuas.or eacnvuancu rou o aa r enerou onvuas,enerae recoresos.orn varou msa exa smorees,noermnaoormna oona sneorerom meuneeraeeaaan rseuroansceor cam ttorneoceto.: moa mnconuse o aneaorensuerravnece croamms roeucsoarnss,ens oousans,unres oousans, u eaceansurance cam recor mancu or a numer onvuas. ona, aa reosor maeeneraeroue meue coumns.s a resu,eneraensurance cams anass o mons o coumns oeao a srucureauraa ae. orr,m aaoueeansurance camsaa mae oranze accorn eansurancerov,eansurance camsaasca arraneoe vewenormaon a ers,aens, aneacareroversn orero sownanca eaa mcaaree aron vvaaenrss e.uran n ruc ese a, c oeoaen no cnso aurm rraaa cnecreon s ca re csma ose naao s vse u nr aovc s eeas nsro w av cnae azeo ooon caavnu cona nss ons csonreseonn. ana ma anereamen oenvuas w resecoeooca an mone ranwereaeaa reosor maeenerae an oranze anaznneraeaa ransurance camsaan a mannera enaeseaa sore e eaures eosor oeurer anazeoeermnerens, caracerscs, mae, anornss w reseconvuasn wc one or moreooca conons reosorresen.n sourc ex aam wae,aea aenassur oannece o co meesc maaroece sourrees,nooecnae croaneoansareamens,osaes, manuacurers o mecaons,sruors o mec , maeeermneor avennvuaase oneansuranaons, oranosesnvua.n varous exames,eaaneraon an anas ce camsaaorememen one or moreaesancae correaon s ssem maenerae an an varousreamens, smoms, o seweeneansurance camsaansurance camsaa.urer,erooca cononsa corresonoeea enomcsaa recors oeronuer oaeaa reosor maeenerae usn amouns oeansurance cams nvuas.n varous exames,earenvuas oeneraeeneraaae maaae mace wenomcsaaorerou o neraneenomcsa rae rosor . weeans ecors orerou onvuas eermne correauornanscee cwaemens reecorressence, oe onaea orn meorreaoonm aanre arnsaass a sresreem ma enomcsaa recors w oer caracerscs onvuasa arencsenne eansurance camsaa recors a exsn ssems arecaa uenaeoe ttorneoceto.: meoerermneen.omorc e cxaamracee,rsecsa oannervaouna asn aana cosrrses ssem maeermne one ornvuas,mn oreamens,osaes oreamens,onoreamens receve saus,resence o one or moreooca cono anoses onvuas, smon ooca conon, one or more ns,resence o one or more smoms o a eermne eaanerao comnaonsereo, anee.ase one correaons , coors onvuasa mna anen aneass ssem usneneraeaa reosor wou noaveeenenen exsn ssrom one or morereamens maeeneaecnuesmemeneon ems.n one or more exames,erocesses an cams recors n or eraeeeansurance cams recors aneenomcsmemen ecenc-enearoeneraeeneraeaa reosor mae comex an amoun o com ncnecnues, ssems, anrocessesn orero mnmzee nu onne r oers mouorrcees uuseoeneraeeneraeaa reosor .normaon sore eneraserave exames,eaaene ssem ma access numer o aonaaa recorsaaa rencosor oeneraeaasesancue a erou onvuas.neusrave euxaemnormaon reaeo aeas aoron o ncuesnormaonncan weernvuaes o areure,e aonaaa recorn wcun cancersresen.eaaene ssemncue man a e coor onvuas eren ses oaarocessnnsruconsoeermne a coor xecue aura o n wcun cancersresen.n varous exames,e a oonerou onvuasncaenormaon useoeermne a saus o annvua wa reaa recor ma suc as one or moreransaconnsuranceener secoun cancer, seases coes, an one or mo , one or morenernaona casscaon oncun a coumnancaes wereeansuranceransaconaes.n aono coor,e aonaaa recor maer anncunevua sncueneun cancer e saus oenvua w resecoer aes ceonucmnncan a conenceeve o meca recorsuaraenso a a sncnemearaceaaraam re oo as coormue on. au nrnc ca varen occ uue srr ee. xamoes,ncororae ororan oon ane o anearasosn ss oseme com aeas ane ounure asrc,e,c anure.n o mnea or meoreer eoxrammees, aeeasaa a aoroonn oa coem ouerano snss oemse coam arue ane aarsc oneec oure conro mae, meaenraornmee, orm onee omre mnoere ttorneoceto.: ne ar saerovnc aenro anvaesrs sas aemso a.eans on oene or o m coornros, manans, ormemenseaa e oeraons oe comun arcecure e aona exames, aeas aoron o asrue comu maeerorme a numer o serversn en envronmen. .e meca r comun arcecure mancue a meca recorsaa reosor onvua ecorsaa reosor ma sore meca recorsaarom a numer resus,anso.scee msencoarm raecoorn,s cnaaca m oasenrvcauoens,maennaneaormanoonrm,aaoonra, noores eacareraconers, mecasororms,anosc reuesorms es o orerorms, mecanormaon cars, one or mor , mecaroceure varous exames,or avennvua e comnaonsereo, an soor.nnormaon oanerom one or ,e meca recorsaa reosor ma sore e comun ar mcoreeceuarecareraconersas reaeoenvua. oannaaacaesrome meca reco mrasaerorm oeraon ancues exames,eaaacaes mae oanen resoa reosor .n one or more meca recorsaa reosor or m nseo one or more reuess senoenvuas.n one or more eca recorsa corresono one or more comun arcecure u asn oonna exames,eaaacaes mae oane e n one or moreusrave e or more acaonrorammnnerace cas.o an aaacae exam maes,e a orsaaaacae, a seconaaacae, unvuaaaacaes,, mnae c uosrrnesone c momun arcecure.envua.or exame,ersaaacae manceuca recors o a resecvenvua,e seconaaacae mancue meca rece meca recors o ars ane aaacae mancue meca recors o aorrsn ov a seconnvua, nvuaaaacaes,, mancue ua. n one or a numer o comonens. comonen msorae e cxoames,nvuaaaacaes,, mancuenvua mo rresono meca recorsromereneacarerovers.n one or comreo anensona exames,envuaaaacaes,, mancuenvua moreeacarea croovrreserso.nnoeuesrernavear exsa om mee ocau rerceor,se saeco conrresaoanacoa oene or m onae onrc muoree aurssr caomveo enxeanmes,, a seeconrs c coommoonneenn, u mao anncue co amrosnenoron. on ttorneoceto.: m meeccaa r reeccoorrss o o a annnnvvuuaa,, ane seceon co cmomonoennen m maancue a seconoron o meca recors o annvua.n varous exames,er ncue aroron oo meca recors o arseacareroveror s comonen ma correson ma corresono meca recors o a sec envua,e secon comonen r comonen ma corresono meconeacareroverorenvua, anenvua.n one or more aonausar recors o areacareroverorencue ars secon o meca recors oave exames,ers comonen mao aanosces orroceur envua, suc as one or moreorms reae o meca recors o e, ane secon comonen mancue a secon secon oeraeonnv,ua,e su cocm asu ana arocoec reuor oenvua. aaacaesoen a corus onormaonoe arneaz marerocessnvua ererocessn oaaacaes oanerome e.n one or more exames,ncueransormneaancueneaaa mceca recorsaa reosor, ma aaacaes mancueransormn aea aes.or exame,rerocessne recorsaa reosor o macne encos aoron oeaa oanerome meca aaacaes mancueerormn enormaon.ousrae,rerocessne oeraons w reseco aeas ao one or more oca caracer reconon recorsaa reosor. converron oeaaacaes oanerome meca e meca recorsaa reosorno aeas aoron oeaaacaes oanerom mae sueceo a numer o oer macne encoenormaon,eaaacaes one or more cara aons, suc as one or morearsn oeraonsoenoeerorme wcer rse osre scrno as oea csa aracorerson or o onee ora maoreac eanes o oearaneonsroma aere m uenacae recorsaa re ncueeermnos nn onoer n oror mmo. areo enxanmcuese,nenrevrocueassnaa oacnavesuaaasaacaes ma romurer anass e comun arcecure.n varous exameoe excue comonens onvuaaaacaes mae excuerom a cor s, one or more e anaze.or exame, w resecoe seconaaacause onormaon o arcecure maeermneaers comonen soe excu,eero commuun anass e comun arcecure.n one or more exames,e comurner arcecure ma anazee comonens,, anor w reseco one or more ttorneoceto.: uerweorr ansaossene a coemasu onne a orceec coumreonen.sn one, or m,o arneoursro excuerom comun arcecure maarsee comonens,, anorave exames,e moreewors ann resonseoenne one or moreeworsoen one or , anor,e comun arcecure maeermneo excnu ae comeonen, comonen,, anor romurer anass e comun arcecur resecve exame,e comun arcecure maeermneaers comonene o.oer seescosn.naease saccenaareos,es c aomesu renu arsconecourrmeor m onae oer meromreneaanosecroceures or soe excueromurer anass e comun arcecure.rs comoonen e comun arcecure maeermnea aeas one oe secon comonna, anor corresono one or moreaoo reorsor annvuaase on oen eworsncuen aeas one oe secon comonen ore comne or more esensances,e comun arcecure maeermnea aeas aonen.n secon comonen anor aeas aoron oe comonen soeornocn oe e corus onormaon oeurer uen n ao anaze e comun arcecure. rome meca recon, a suse oe comonens onvuaaaacaes oane .n varous examresaa reosor maencuene corus onormaon corus o s, one or more aona oeraons maeerormeo narrowenormnormaon.or exame, one or moreueres mae aeo a suse o ma exaraocn onaornmeaoronmrome mee ocnae r oerco mrosreaaaa reaocsaoresa. saes one oer m onoere oru meres ueres.n aeas some exames,e one or moreueres mae ar ore aeonvua comonens o aaaacae.n one or moreou oueresa are rou oueres maeermnenormaonoencuen usrave exames,e an aonanormaonasoe excuerome coruse corus onormaon more aona exames, one or more secons onormaon.n one or mae excuerome corus onorma o aeas one comonen o aaaacae n one or more aonausornav. co e exames, aereermnnaers commounenn soe excueromurer anass e comun arcecure,eo aeas o anrceeec suerceon c momaoneenn cause o orne oer more comueroensenoem.nemeensee sc wenar roess,ece ttorneoceto.: o sence oorn moarenuecraeess maameersmorneora on ae s oecr moonre ooeo seccaon co comonen, suc as a rome corus onormaon.n varous exames,e onnons,soe excue receoenn a numer oewors anor comnaonse o ore moreueres maeeas one oe secon comonen ore comonen.nwoersesnnscauen a comun arcecure ma excuerome corus onormaon onen ocres m,e orons oenvua comonens oeaaacaesancue one or moreewoore or comnaons oewors.n one or more aona exames,e comun arc rs ma excuerome corus onormaon a numer o wors, a numeecru ore c onaer oacr meros,re anororo ans n oumeern o svmuao csoown one or moreeworsa arencuen urer, a o omonens oeaaacaes. corus onormaonoeeremraneon c,e comun arcecure ma anazee comun arcecure maracerscs onvuas.n one or more exames,envuasaave one or moreae annoazeee corus onormaon oeermne ma anazee corus onorm s.n varous exames,e comun arcecurencave o aooca conon.oaron oeermne one or moreomarersa are e corus onormaon oe exearmmnee,e comun arcecure ma anaze caracerscs.e one or moreenec ca nvuasavn one or moreenec varans o aenomc reon racerscs mancue aeas one o one or more usrave exames,e one oa corresono aooca conon.n one or more varans o ae r moreenec caracerscs ma corresono one or more usrave enomc reona corresono ae o cancer.n one or more aona o xames,e one or moreomarers ma corresonoeves o an anaeen coursuse o o a sece rane.ousrae,e comun arcecure ma anazeeeves o onneo ormr maoorne smao meoeercmuneesnresvenuaas aarvennecvaevse o o on ae oro moorecar cooenns aonn.onr eeseerm scneenaervoess, oe an caomeus onn arcvueacsu.ren one o mra mo arena azeo rensau esxa omaeso,raeo cromesso arce orec muorree sm maom asn aarezereseen coraus ar o un on ennocramaveo on aoooecearm connenonv.nua onsen or w moc urer exames,e comun arcecure ma anazemannormaonncuerene corus onormaon oeermnenvuasn wc one or moreomarers are ttorneoceto.: resen. or more macnne oenaern orn moerce enxaumeseos, anae czoemue cno arcecure mamemen one e comun arcecure mamemen one orrus onormaon.or exame, aeas one o one or more conv more arca neura newors, suc as neworso a ouona neura newors or one or more resua neuramemen aneaazee corus onormaon.e comun arcecure ma aso moes, or one osr m oonree o su oneor or v mecoroer r manacomnesoroes asnaeczenuee cso,r onues o or mnoroeenarov e corus onnor amaeaosn somemeremoremnano onnse, ore m coormeuuenres ar wce rcesureerma co mo ean co arna.zenormaon.e one or moreueres ma corresono one or more us o comnaons oewors.e one or moreewors anor com ewors anor corresono aeas one o caracers or smosa c naons oewors ma conons.ousrae, aewor ma corr orresono one or moreooca enomc reon, suc as .n one esono caracers reaeo a muaon o a crera mae assoca or more aonausrave exames, one or more corresonso a co e w comnaons oewors.ousrae, a crerona a secesancmnaon oewors mancue a numer o worsenresen wnnvua, suc ase oe one anoern aoron oe corus onormaon or an caracers o one a worsaue,ooressure, an swen occurrn wn corus ononoer.nesensances,e comun arcecure maarsee varo rmaon ore one or moreewors anor comnaons oewors.n comunsa exoanms oese,wnor ress aorenseresoenene arcmconrnancea we one on oer m orore m correerae,wors anor arcecure maeermnea aooca cononsresen w resece comunnvua. o aven ase ane cno omneu orn mo arrce aecuorena exa mmae asn,aeze onem oare msornecuueeresn mae ceormae-normaon w resecoemaemaes.eemaemaes maeeneraeuass o on a nnuamzern o am nuamesern oo ameamesaen wmace. a e e noesoe sccaen caornos,oen cosmreusenn a anrc aecruean mema aanaemzeamesaoesencerumene an meea csourreu os o smnoarrmaoenween we rmesaeecsnoc ounee orre n moree ttorneoceto.: c somruasr oonro arnmnaovnuas an aeaes aemreaseom vaaeuse.,ne s coumaouns weree measure o eermnea a caracersc o aooca cononsresenn arcecure ma arcecure mear,e aer omenranonnv,ueanseraavena oan ser ourc muoreres cn aara sce oerernsv acas,uae. comun avne one or more caracerscs.n one or more exame ornvuas maeneraeaaaesancaenvuasavns a,nen comun arcecure anornvuasavn arou o caracerscs.or exa vua caracerscs maenerae arsaaae an a seconaaamee,.e comun arcecure mancaenvuasavn one or morers caracerscs aneersaaae mancaenvuasavn one or more secon caracers seconaaae exames,ersaaae mancaenvuasavcs.n one or moreusrave or aooca conon ane seconaaae man one or morersomarers more seconomarersoreooca conon.encaenvuaavn one or corresono one or morersenomc one or morersomarers ma conon ane one or more secono varansa are assocae w eooca enomc varansa ar marers ma corresono one or more secon aaaes, mae anssoccae weooca conon.n varous exames,e wenvuaaa ae weer or noe one or more caracerscs assocae usrae,ersaaaaees m,an areresen w reseconvuanvuas.o morersenomc varans ar cue arsncaonornvuasn wc one or one or morersenomceresen an a seconncaonornvuasn wce aaae varans are noresen.n one or more aona exames,ersncae we mera orn nocae smon saus onvuas ane seconaaae ma ooca cono nvuanvuasave receve one or morereamensor aae mn onn.e or moreusrave exames,ersaaae ane seconaa a aave rowsa corresononvuanvuas.n aeas some exames,nncunev aueaasener maeresennnvua rows.envuaener ma varous exame osn,e oe anvanuumaercen carearc meras ore smresoensna a coarraesaocnaeo anan corvresuaon.no ann ovnuav.uoaumnnsv ouaes wrsa reasaece s a saus o one an or meor seec conaracaearsacse.or e mxaamne,caee ttorneoceto.: c aoumannusm oerce caaraacearse osr sm,os maannccuaee aneernesenerancues aeas one o caracerscsor avennvua.ur ce or asence o one or morencues arsaaae an a seconaera, aoueusrave exame oure enerae moreaaaes oreweraaa ae,e comun arcecure man an oeraon,e comuesn. arcecure ma soreeaa srucures er asaoanaaeaa re anosoorr.e soerc eoxnamaea,ae comun arcecure ma sore aeas n v e n annermeaeaa reosor . saoraearo anus e eexamn aneremse, e sae ecers onaaa a rea aoa aseoer an m.ane oen s seec oorn moareaauserave m eaxameeesm,oerarrs eo orenenermeaeaa reosornerareen aeoeneraeaa reosor .n one or more exames,e scenaroesaa reosor maeerocaenerae anor uae.nese co ,aa srucuresenerae e comun arcecure ase on anazne wrenus oenneorrmaaon mae sorenenermeaeaa reosor un ame reoroa aa renosaor soe aeas one oenerae or uae. eneraeaa reoso a srucures sore enermeaeaa reosor o e-encaonroc r ,e comun arcecure maerorm one or more reoso esses a oeraon.eaa srucures sore enermeaeaa morer maee-enen oreroreserveervac onvuas.e one or croer-aenceccanonuersocoesnseosr mmaaonnc ouen avuans onnceu ore morne eeecaroan scraucurmemene enermeaeaa reosor.n one or more exames,e co es sore maeneraeoensa corresononvuanvuasaamun arcecure aa srucures oenermeaeaa reosor .e venormaon soren an one or moreasunconsonormaon reae oens maeenerae more exames,e one or moree-enc onvuanvuas.n one or uncononormaon corresonn aonrocesses mancue an a sanvuanvuas.n varous exonvuanvuasoeneraeoensoreoe-en eaa srucureames,e one or more croracecnues ae same or smaroose aeso snore enermeaeaa reosor maee reosor oures an.ormaon oaneromeeansurance camsaa ttorneoceto.: aa srucuresn o coenraunocnon, we comenuenra aercaecau rreeoso mra so.reore exea-enenormaon sorenenermeaeaa reosor or avennvua mme,en conuncon w aonanormaon aouevennvuanenearae sore reosor .ousrae,eneraeaa reosor ma sorenormaoeaa vennvua oanerom aeaswo oe moecuaraa reosor, oanor a eeansurance camsaa reosor , an oaneromenermnerom reosor .ns wa,normaon aou avennvua oanerom ae naeaa saraeaa reosores mae soreneneraeaa reosor .umer onormaon aounvuasas oaneromeerenaa reosos a resu, anazeoeer raeran anaze searae as w man exsn s res mae mae usen vaoro vuas eaxaem onees o,r meonreormeaermonn saoroens maeenermees aae aems na. ear raeoosor anass ssem.or exame,eaaneraon an anass ssem ma an annormaon oaneromeeansurance camsaa reosor an naze aa reosor oeermne caracerscs onvuas.eaane moecuar anass ssem maen anazenormaon oaneromenereraon an reosor oeermne weererece caracerscsenemeraoeaanormaon oaneromeeansurance camsaa reosor anrome moecuaraa reosor corresonoe caracerscsore same me reseconormaon so nvuas w e onre enermeaeaa reosor . srucures sore ee orn meore croracecnues aeoe-en eaanormaona was usermeaeaa reosor ma uzee same or smar oure.or exaoenerae aeas one oersoens ore seconoensecnues usn a cme,e oeraon mamemen one or more crorac aeas omnaon o aeas aoron o ars name oe resecvenvuas, r aoron oeas name oe resecvenvuas, aeas aoron o aae ooca oe resecvenvuas, aener oenvuas, an aeas aoron o anermoenener oe resecvenvuasoe-en eaa srucures oe sameaeaa reosor. uzne same or smar croracecnues anenerme ora semaara r seuosseor ono arsm waeroen useooe-enenerae aeeasa oane s orucueresrs sooreens oer ttorneoceto.: senc secroonnzeo wensn,ormeanoonrmoarone s saomreenveunaesrmeaaaeveanao rermoasoonr maeneraeaa reosor .oen sorene aa eraeaa reosor anenermeaenv reosor ma sorenormaonorousans,ens oousans, uo mons o eneuaras.euas, woue a o sncronzeenvuasavn recors sore a sece croar raeoscorroo anenermeaeaa reosor roue use o reosor aneaa srco asescreeren,eaa srucures oeneraeaa w a samenvua ma nuocures oenermeaeaa reosor a are assocaeneraeaa reosor ane soerenn a manner sucaenormaon sore e mae rereveoeeror avenonrmvaon sore enermeaeaa reosor enrove eaaneraon an anauas,s wc maeaonaccuraenormaon croracrooco asescreeren ma as soseeamo.e asence o a sece resourcesoeermneenormaon sorenener e use o more comun aa sources anenormaon sore enermeaeaeaa reosor rom oero avennvua.ures an usrae exameraocae reosor a correson aa reosor aneneraeaases usene anasssesoenerae anneraeneraeaa reosor.e examerocesses areuss onormaon sore eocaowras, wc reresen seuences o oerrae as coecons oocsn arware, soware, or a comnaonereo.eocaonsa maememenen conex o soware,eocs reresen com s are reerence numers.ne more comuer-reaae m uer-execuaensrucons sore on one or arware mcro eaa, wen execue one or morerocessn unssuc asnsruconsncuroec reosusornses,,erroorramms,e o reecces, c oomeraonoennss.,aenaer saruc,u comuer-execuae erormarcuaruncons ormemenarcuaraaes.er oers, aneea oeraons areescres noneneoe consrue as amaon, anern wce escreocs mae comnen an orer anornaraeomem aenn numer oe ures aaaowaram o an examerocess oenerae aennroecersas. aa reosora soreseansurance camsaa anenomcsaa, accor e morememenaons. oeraon,erocess mancueeneranno one or ancuesoensenerae usn arsasuncon.nvuaoens ma cor aaae a resecvenvua o arou onvuasavnaa sore a moerceusaornaoa ttorneoceto.: r reeoossoorr. mna onee or as msoocrea eexam wes o,n aen onr mvorueaoaevnsn.aa sore e moecuaraa an one or morersasunconso a suse onormeoens maeenerae onvuas sore eenomcsaa reosor.n varaon corresonnoerou maeenerae an one or morersasuncoous exames,nvuaoens aeas aoron o ars name o a resecve nso one or more comnaons o aoron o a secon name o a resecvenvnvua oerou onvuas, aeas ener o a resecvenvua oerouu oa onveuraou onvuas, aocaonnvua oerou onvuas, an aae or o a resesc, aener o a resecve onvuas.n one or moreusrave exames,eoens mvenvua oerouneraon an anass ssemas coueoeenomcsaaa reeenerae aaa aonausrave exames,eoens maeenerae aosor.n one or more accesse aaaneraon an anass ssem coueoe moer-ar ssem an erocess ma asoncue, a oeraon, senneaaecuoaraa reosor. camsaa manaemen ssem.eeansurance camsaa aeansurance maceoensncueneaae w seconoens access manaemen ssem ma aa manaemen ssem aneneraease onnormaone eeansurance camsaa re sore aeansurancensurance canm aoso saor an m,. aan oaeermaeonn ss,eme,nrocess mancue oann,romeeaoerou onvuas, wereersa raesonseoeaae,rsaa corresonnmemenaons, armave con ncueseansurance camsaa.n some oreraaoeranserrerosens oanerome memers oerou onvuas one or more exames meeansurance camsaa manaemen ssem.n noeraceaco,eaasranserren an anonmzeorma, sucaeaa ma ssem mae co annvua memer.eeansurance camsaa manaemen camsn ueo aeansurance camsaa reosora soreseansurance camsaoarm maanoaneomre an nu smseerm o mnav auas.n one or more exames,eeansurance aon nazeeoens oeaae w reseco aonaaoensenerae eeansurance camsaa manaemen ssem.eoen oens maeeneraease on a same se onormaon useoeneraee on asonecnu.ne vanrouesa exaame.es,oweeveer,a annnsuvranucae’s caemnsa maa m naonaeemeenerm ssneema msea ttorneoceto.: m soarceoensenceuaennsureancaea caem wsa aa reonoasoorensoeneeerraease onnormaonnormaon sore eeansurance camsaa reos mnenvuasavn sore eenomcsaa reosor.eecnooscora asoavenormaon anesraccervac sanars, suc as an os.eeren comes wea usn a se oeraon,erocess mancueeneran a numer oeners exames,cnonvausauenncoenrs maas correesreonnroom onee or mrsoreasoenusnc reoane.no o ane re or morenvua oerou onvuas.eeners mae unue w resecos aecvvenvua oerou onvuas an are en eene e-ene. ona,eeners manvuraae usnnormaon sore eenomcsaa reosororerou ooenesaserenromenormaon sore eenomcsaa reosor use ana vnrae ersones see ocoonens ea. esn nu v ena rcro s mouns ao exa enmoernmes era, aeonne orme aea reesnecen onveeer orrs mou ma orse oe sane nvner ecuaae ns aunoenermeaeeners.normaon sore eenomcsaa reosoreos resecvenvuas mae soren assocaon weeners suca aear oron oenormaonorvennvuas sore eenomcsaa reosors a accesse usn resecvee mae urer,erners oevennvuas. oeners, sec ocess mancue, a oeraon, oann, usne numer a oer onaarome moecuaraa reosororerou onvuas, an, a coaon,erocess mancueeermnn resecveorons oersaa examrer,esoro anvoen rensevcvuea,orrsonsaa o correes seocnonnaoaeoarensurroaunce o canmsvuas.or vennvua maeenen aono seconaa corresonno moeaaore oevennvua, suc asenomcsaa.ns wa,or avennvucuaraansurance camsaa an m a,oea erocessoecuaraa maeene. reosora sorese r mancue, a oeraon,eneran anneraeaa seconaan r esecveorons oersaa ane resecveorons oenera eaono resecveeners oe numer oeners.or exame,e avenenava rueaosno arss mocaa soonre wea annsuenranceer caams maaa aen useenomo accsc cesasmseaeaaor ttorneoceto.: snosurerance caemnsearaa aenaea reenoomscosr ca mmasaea ororanzeev aecncnvua.enormaon scema.or exame,eneraeaa reosor ma so orno aaa reosor enomcsaaorerou onvuasn a nume reeansurance camsaa annormaon sore e numer oaa r oaaaes.n one or more exames, reaeo avennvua sore arsaaeasa maene.ousrae,normaon neo aonanormaon reaeoevennev ouaeaa reosor scema mae eaa reosor scema.ns wa,normaon acce sore a seconaaae o reosor scema ma resun accessn aonanssen oneaaae oeaa oeaa re ormaon soren anoeraaae n oonseo orr m socreema. aaaea sore usrave exames,eaa reosor scema mancue ars ma sorenormsenomcsaa oerou onvuas.or exame,ersaaae enomc reons,aone csor ores mounanonso, a coane nu umseeros oenereaneomecno rmecosnsa,a c,o mveuraaeons oncan numers o nucec ac moecuesenen a sameavn one or moaa muaons,esnaes, anaennormaon.eaa reosor scema ma a re a seconaaa soresaa reaeo one or moreaen vssnvu soncue eacarerovers an araaaea soresnormaon c aso one or more servcesroveonvuas w reseco one or orresonno resecve eacareroversncae e seconaaae moreaen vsso one or more scema mancue aouraaaea soreser.sonaona,eaa reosornvuas an a aaaea soresnormaon reaeon aoremaaon oerou o orovernmena en a maeamenor servcesrov nsurance coman urer,eaa reosor scema mancue a sxeaaoaee srou onvuas. corresonnoeansurance coveraenormaono ornnormaon e oeansurancean reaeoerou onvruearou onvuas, suc as a ma asoncue a sevenaaaea soresnorms.eaa reosor scemareamens o aon reaeoarmaceuca na onnee or merou onvuas. recorsa c ore exames,eneraeaa reosor ma aso sore meca meca rorresono aeas aoron oerou onvuas.nese exames,e recors.enceor ors m moare oec oaa cnaeracreorm rec oonen oro mnoreaa o reeraosonosr mesa soernerorem mee wca ttorneoceto.: r oensee ocro moree meorcoans rec oors.e aoonnaa,noer mmeaocna reoco rrems mae anazeoeermnenormaon.n varous exames,e corus on oveorouce a corus o oron oe suse oe aonarou onorvmauaon mae anazeoeermne a omarers. sa corresono one or more soreenenres o or meoreoraoan s oruceur seus maeeneraerome corus onormaona anncaonaeoron oe sussee o oee a aonarou onvuas ana soreoe one or moreomarers.e one or onarou onvuas corresonsnermeaeaa reosor.ne or mor moreaa srucures mae sore an resecoeeners oeorone oe-eencaon oeraons maeerorme w eore moneneraeaa reosor suose so ore ae aonarou onvuasnormaon oe meca recors oeoron oe sueasse a ooron oe aonanvuasn reaonoe numer oeners.ere-encaeon a ooenarou o sore e one or moreaa srucures,enormaon sore ennormaon reosor mae aeoeneraeaa reosor.n aeas some exameraeaa ene meca recorsnormaon mae aeoeneraeaa reeoss,oreen- aaa sonrucou orresn seourn oeeeae-ennsuraence m ceacmas raecao.rns vanroorumsa exaomn wes, ree one or more omareraa maave one or moreoca connecons w oeraa ssecoe eneraeaa reosor.ousrae,e one or moreaa rucures soren ene meca recorsnormaon w resecoeoma srucures sornee- moreoca connecons w aeas one oersaaareraa maave one or corresonno aane useoeneraeenomcsaa e ma sorenormaon o muaons, co numers oenomc reon , muaons oenomc reons,es ac moecuesenen a samea s, coveraeaancan numers o nucecnormaon,e seconaa vn one or more muaons,esnaes, anaeno one or moreeac a soresaa reaeo one or moreaen vssnvuaso resecv arerovers,e araaaea soresnormaon corresonn or e servcesroveonvuas w reseco one or moreaen vsso one e moreeacareroversncae e seconaaae,eouraaaea sores rerasoenaon aoermaaonnsu orancee croomua on onrvoveuranms,enea enaaaa maeeaa smoreensnoro sremrvacoens ttorneoceto.: reoavensuoranecer coouver oaennvormuaas,oneo srxearoaua oe snornnormaon corresonnonsurancean reaeoerou onvuas, orevuas, suc as ae oeanormaon reaeoarmaceucareamens oa sevenaaaea sores n varous exames,e meca recorsnaea maee arou onvuas. reosor eneran aaaencunrsoensenerae usenoeneraeaa nvuarsoens ma corresono a resecvenvua arsasuncon. avnaa sore a moecuaraa reosor. ona,e oa aaroeu onvuas meca recorsaa manaemen ssem an meca recors mae seno a onvuas mae oanerome meca recorsaaaa corresonnoerouoeaae.urer, a numer oeners m manaemen ssemn resonse aserenromersasuncon.aaeenerae usn a seconasunconoens reaeo eacnvua oer cener ma corresono one or more seconaa mae oanerome mooeuc onvuas.sne numer oeners n varous exames, resecv uaraa reosororerou onvuas. resecveorons oeeorons oersaa maeeermnea corresono aa reosor maee sneconaaorerou onvuas.ns wa,enerae resecveorons o eraea sorese resecveorons oersaa ane eners. e seconaan reaono resecveeners oe numer o reues maereneraeaa reosor sorn meca recorsaasenerae, a sorenene reecreaveeaoae reeromsnoer.aa we reu reessecncou ae nsu mmae orn oe onr mvoreua sesarcav cnraa n one or more exames, a suse oe numer onvuasavn on era. caracerscsa corresonoe one or more searc cre e or morenormaon oe suse oe numer onvuas mae anra maeeermne an o sncance o a caracersc oe one or m azeoeermne a measure conon. ore caracerscs w reseco aooca eermneno oener oesre moreusrave exames, one or moreenomc muaons mae roveoe susenne suse oe numer onvuas an aura oreamens exames, resec oe numer onvuas ma asoeeermne.n varous eermne, suc avse re suarv wvoar ra suesrvvoar raee ssu.sne a oease s noumme eerxa omnes,veua msea msuare oe ttorneoceto.: sreanmceannsce an ma a ceonrormesco mnuaoo snur ovvae r oanee o wr mo rreeseco areamen oeura o o sncance, an eecveness o enomc muaons.ase on measure maeeermne.n one or morereamenore suse oe numer onvuas aave no receveere exames,nvuasn suse oe numer onvuas amouns oerea eamen maeeermne.ne or moreeraeuca eecvenvuasaavem neon r mae amnsereoenvuasne suse oe numer o oaases useou arneazse e ace nav orae maowere on saa orm raemen o. a ann enxeamraeeroacaes rseooenerae a numernsurance camsaa anenomcsaa, accorno one sora soresea rocess mancue, a oeraon,eermnn a or morememenaons.ensruconsa are execuaen reaonorsaa so rs se oaarocessn eneraeaa reosor ma soreeansurare anneraeaa reosor. commonrou onvuas.n one or m nce camsaa an moecuaraaor ansrucons maencuen aura oore exames,ers se oaarocessn o aaarocessnene.ac oe ses oaarocessnnsruconsa arear rocessnene mae execueo ses oaarocessnnsrucons oeaa exame,nvua ses oaar enerae a resecve anacs reaaase.or execuaeoenerae ocessnnsrucons oeaarocessnene mae comnaons onormaoaasesancue seceorons onormaon anor exames,nvua n sore eneraeaa reosor.n one or more aona e execuaeo ses oaarocessnnsrucons oeaarocessnene ma reosoroene arnaaze an mo orons onormaon sore eneraeaansrucons maee resecveaases. ona,nvua ses oaarocessnneraeaa re execuae w reseconvua suses onormaon sore e roc eosroocres.s ma asoncue, a oeraon, causners se oaa a suessesn onserurcouon osonev exeucausen woecne araeo arsaase.ersaase mancae aa oca cononsresen.ers se o rrocessnnsrucons mae execueo anazeaa sore eneraeaa oeneo osro mroen a coor onvuasn wceooca cononsresen.n erso sere ousaraavreo ecxeasmsnesn,sreucoonos mcaa cone exoencu meaonc aunae aze canacear. sooreusraee, ttorneoceto.: vnareoruase examaa rees,oseoraaoroecnessn a cooern oe mnavnucausn wcun cancersresen.nnsruconsoen coors onvuasn wce meruee ses oaarocessn resen. nooca conons are execueo ananz oen ae oera mso ornee e oxameaes,nseuranrs se oaarocessnnsrucons mae a coor onvuasn wceooca cce camsaa or moecuaraaoeermne oaarocessnnsrucons mae ononsresen.or exame,ers se eansurance coesresenn execueoennvuasavn one or morenvuasn wceooca ceoanonsurance camsaaoeermne arou o rocessnnsrucons mae execueoensresen. ona,ers se oaa areresenn aenomc reon o n nnvuasn wc one or more muaons envuasoeermne a ucec ac moecueserverom sames oanerom n aon,erroouces osn mvauanscn wceooca cononsresen. se oaarocessnnsruconsa ar ue, a oeraon,eermnn a seconneraeaa reosor.e sec e execuaen reaono seconaa sore e eerenromers se oaona s soer oaa sore eneraeaa reosor ma reaonoers se oaarocessenneneraeaa reosor an anazen corresonors coumns o one or srucons.or exame,ersaa ma reosor ane seconaa ma corr morersaaaes sore eneraeaaaes sore enerae esono secon coumns o one or more seconaa rocessnnsruc ooenrsaoona e ex,a r ecueeo eroscoeosrs. enera mea a sencconue caaaussenneca secnon on se oaareamensroveo a secon suse oerou onvuas.e sec e or morencae a suse oerou onvuasaave receve one or moronaase ma one or morereamens maeroveonvuasn wc oneereamens.e conons areresen.n one or more exames,e sec or moreooca mae execueo anazeaa sore en on se oaarocessnnsruconsnvuasa recevee one or morereaeraeaa reosoroen a coor o rocessnnsrucons mae exec mens.ousrae,e secon se oaa orenomcsaaoeer ueo anaze aeas one oeansurance camsaa n one or moreusravmen eexa am coeosr, oen secvonua ses oa raecaevreoceses onnen osr mruocreonresa mmaense. ttorneoceto.: enxseucruaneceo caemnsaanoveuaersmanven a ornoeu or o morneveaunsurance coesresenneareamens. asa recevee one or more suse oerouure or,nevroucaesssan mcauensc auoe,r aon o oeraeon,eermnn arnvuasa overas w aoron oe secon suse oersro suse oerou o resu,er suse oerou onvuas corresonsonvuu onvuas.s a ooca cononsresen ane one or morereamens arer asn wcoe , mancue anaznersaase ane seconaaseov we. r ,erocess suse oerou onvuasoeermne a measure o sncanceesecoer er suse oerou onvuas.n one or more exame o a caracersc oearnnecnues or sascaecnues mae ae s, one or more macne one oersaase ane seconaase w reseonormaonncuen aeasnvuas.e measure o sncance ma correscooer suse oerou o sncance w resecoe caracersc.n one no a sasca measure o o sncance ma corresono a or more aona exames,e measuren wceooca cononsrroesae oe caracerscenresennnvuasreamensrovn oeneo or meornevusuraasven n e wx.amces,eeo coarcaace crosnc moansncrueseen o.nen or o more more aonausrave exames,e caracersc mancueeres ne or o aenomc reon o nucec ac moecueserverom s ence o a muaonn wceooca cononsresen.n varous exames oaneromnvuaseas one oersaase ore seconaase m ames,normaonncuen a e caracersc w reseco one or mor ae anazeoeermne anmac oncuen aeas one oe e mercs.n one or more exames,normaon an amoun onuen rsaase ore seconaase mae anazeoeermne cononsresce o areamen on a survva rae onvuasn wceooca ersaase oern.en se ocnoen or maaosree muraere e axnaamzees,onoermeramonne annc aumeounn o aneasue onne o a muaon o aenomc reon on a survva rae onvuasn wceoocec o cononsresen. ona,norma a a onncuenersaase ane secon resaseec moanev anuaaszen woceermeneo aon acmao cuonn oomnsacre osen one an or mno wrecrea omneen ors m wore ttorneoceto.: enomc muaonsur aere asuosrraeseesn a. o a comuer ssem wn wca arammac reresenaon o a macne neorm macne oerorm an one or se onsrucons mae execueor causne an exame, accorno more oe meoooesscusseeren, accorno arammac reresenaon an examememenaon.ecca,ure sows a wn wcnsrucons oe.e., macne ne exameorm o a comuer ssem, oer execuae coe soware, aroram, an acaon, an ae, an a, or meoooesscusseoerr causne macne oerorm an one or more oe e macne omemen mae execue.or exame,ensrucons ma cause escre w resecoenurese a,rc,,ecures anramewors,,,,, , escre w resecoures, a,n an, resecve, ano execuee meos aarcuar macenensrucroonrsammeranos coarrmr oue,e re ensereaec sc,r nvoe en-. arnoramusmreae maucncne no mannerescre.n aernavememenaons,e macne oerae onsne evce or mae couee.., neworeo oer macnes.n s as a sanaone macne ma oeraene caac o a server macne or a neworeeomen,e cen newor envronmen, or as aeer ma a cen macnen a server- envronmen.e macne ma comcnen aeer-o-eerorsrue newor comuer, aersona co rse,u noemeo, a server comuer, a cen ox , aersonamuer, aae comuer, aao comuer, a neoo, a se-oeeone, a smarona asssan , an eneranmen mea ssem, a ceuar omeevc e, a moeevce, a wearaeevcee.., a smar wac, a smar a newor sweec.,., a a n semwaror aranec,e o,r o aner m samcarnee cvacaes,e a o we exe acunance,e an nserwor rouer, seuena or oerwse,a sec aconsoeaen e macne.uurceorns, on a sne macne susrae,eerm “macne” sa asoeaenonc, wuee coe ocneo onr o mo mraecnes anvua oron a an execueensrucons oerorm x oamee mse o coomoouensesvcucsesee mrean. crcuse.., moues, or meca ncueoc, one or more comonens, ceran oeraons.n a nsms.rcus areane enes conureoerorm exerna enes suc ans e oxaemr cer,c curcsuns m aa sece aerran maenneer...,nn aenrn eaxam ore w, one re osre mcoroe ttorneoceto.: coamrwuareer srosceemsssorse..,ro ace ssasonrsao mnea, ceen co onr server comuer ssem or one or more acaonoron, or an acaon as a crcure sowaree..,nsrucons, an asescreeren.n an exame,e soua oeraesoerorm ceran oeraons reaae meum orn aransmssoware ma rese on a non-ransor macne e unernarware oe crcun, sna.n an exame,e soware, wen execue n an exame, a crcu m caauseesme cercuoerorme ceran oeraons. or exame, a crcu ma comrseecae crcmene mecanca or eecronca.oerorm one or moreecnues suc asscusur orocas secca conure rocessor, aerorammaeae ar se aove, suc asncun a seca-urose .n an exame, a crcu mraa comrse or arno acaon-seccnerae crcu encomasse wn aenera-uroserocesso rammaeoce.., crcur, as eemorar conuree.., sowareor or oerrorammaerocessora ma arecaeaeecsonomemen a crceuror mmecaen ceran oeraons. we ermanen conure crcur, ornemorar conurec carce..,necae an soware maerven ure.., conure ccorn, cose anme conseraons. a an en asscaer cmon “scrrcu”s unersooo encomass aane en,eemorare..,ransor conuruce,ermanen conuree..,arwre, or oroerorm sece oeraonsee..,rorammeo oeraen a sece manner crcus, eac oe crcus nee n.n an exame,ven aura oemorar conure or exame, weree crcu oe conure ornsanae a an onensancenme. eenera-u s comrse aenera-uroserocessor conure va soware, mrceus. ao onwroserocessor mae conure as resecveeren crcus aeren c earnes ma accorn conure arocessor,or exame,o consue aarcuar na annce e oxammee, an crcou cosn msauer aoveerennor cmrcu a aerennsance ome. rom, o aono, an recevenormaon coueoer o crcus.ns exame,e crcus mae reare asen communcave c ne or more oer crcus.ere mue o suc crcus exs conemoraneous, aonmmuusnescaonas m coannece aceev cercurso.un smnaransmssone.., over arorae crcus con emenaonsn wc mue crcus are acevuere,o orr exnasmanea,ero aueere snoramees a,n co rmemreuvnaca oonnsoremwaeoenn snuc me cmrocru ssr mucaurees ttorne oceto.: aon w socreee m ouuue o crcuas oaevrea acocnessn. ao mre emxaomree,v one crcu ma erorm an oeraon coue. urer crcu ma en, a aaerme, acceceo wc s communcave rocesse sore ouu.n an exame, cr sse memor evceo rereve an communcaons w nu or ouuevc cus ma e conureonae or receve onormaon. es an ma oerae on a resourcee.., a coecon aeasara,e varous oeraons o meo examesescreeren maeerorme, ore one or morerocessorsa areemorar conuree.., soware ermarnmenanen con counreu,r seucoroecresosromrs mae r ceoenvsanue oeroraceossnosr.-meemeernemorar or oeraeoerorm one or more oeraons oruncons.n an e crcusa eren ma comrserocessor-memene c exame,e crcus reerreomemen mar,e meosescrercuesr.en ma e aeas ara rocessor one e.or exame, aeas some or a o e oeraons o a meo ma eerorme oerao onrs mroacesseorss orruroece assmoor-nmeem oennee or m corcruesr.ocesesoresr,o nrom oance o ceran o e sne macne,ueoe across a numer o macnes.n an exn resn w n a rocessors ma eocaen a sneocaone.., w ame,erocessor or envronmen or as a serverarm, we n aome envronmen, an oce across a numer oocaons. n oer exameserocessors ma esrue reevan oeraones onne a " ocro muor ceomrocuesnso"rs en mvaron amsoen o oerra ase ao "so suwaorre aserormance o e rou o comuaears.as eoxra emxames oe, a maecasne ssomnec oune oroercaessoonrss m,a we a se eer srv eoc orme” eer a en accesse va a newore..,enerne an va one or more ar aons e.., caonrora oraeneraces xamemmneemraecneasonss. memenen a eecronc crcur e.., aaraus, ssems, or meos ma en an comnaonereo ,n comuerarware,nrmware,n soware, or roramrouce.., .xamememenaons ma ememene usn a comuer a macne rea a comuerroram,an emoen annormaon carrer orn aaraus suca as ae mroeruammm,aore exercoucesosnor, a, c oormou coenr,r oor mue oeera coomn ou,ersa.arocessn ttorneoceto.:ncun come co omruneerrrreoeraman muaaese, a wnre mnan aeneorome onr aonramormm,nnanuae, a san-aoneroram or as a soware moue, suroune, or cun as comun envronmen. comuerroram maee oer un suaeor usen a comuer or on mue comuers a one se orsroeoe execue on onenerconnece ue across mue ses an n a a communcaon newor. rocessors execunn e ax caommeu,e orerroaroanms moaeroermeruonrcmeons o oneer oar mnor oennrouramamaa ae eneran ouu.xames o meo oeraons ma asoeerorme, an exan aaraus maememene as, secauroseoc crcure.., aerorme ae arra or an acaon-s ammae e comun ssemeccnerae crcu . enera remoero mancue cens an servers. cen an server are e reaon m eac oer aneneraneracrou a communcaon newor. res s o cen an server arses vrue o comuerrorams runnn one eeocnve c aomrouraemrsm anaea cvonm au cnen s-sserevme,r re waonse aore ecacae oear.nomaermwenarae aonns s oo wwaeree arrcoemcureemse renu cerera connsunecraonoan.encecraman,en w coen aurreecaearwaare coce ,nemorar conurearwaree.., a comnaon o sowaere.., an rorammaerocessor, or a comnaon oermanen anemora e an a arware mae aesn coce.eow are se ouarwaree.., r conure soware arcecuresa maeeoen examememen caomunevce an e comunnev ance exam mea,ee c coomnneucneee.vce ma oerae aosn as. sanaoneevce or n a ne ., neworeo oer macnes. caac o eer a serwveorr oeeomen,e comunevce ma oeraene exame r a cen macnen server-cen newor envronmens.n an new, comunevce ma ac as aeer macneneer-o-eeror oersrue ,or envronmens.e comunevce mae aersona comuer, aae r ae, se or- aon moaxcne ca, aa meo oe exeeceunonen,s ar wuceo ansseanucee,n aa ne orw oorer rwouseer, s swec or aconsoeaene..,erorme e comunevce.urer, we on ac snn comunevce susrae,eerm “comunevce” sa asoeaenoncuee ttorneoceto.: annsru ccooencsoon oer moramc annes onea or mnorve ouae m oreoon execue a seor mue ses o xame comunevce maoncouees ascroucsseessoreren. rocessn un , aracsrocessn un oro, a man me.., a cenra sac memor, some or a o wc ma communcae w eac o emor an a comunevce maurerncue asa un , an aaneurm vear aus.e e.., aeoar, an a usernerace navaonevce e..cnuevce exame,esa un ,nuevce an navaonevce, a m maouse.n an screensa.e comunevce ma aonancue a soraeeve aouc rve un , a snaeneraonevce e.., a seaer, a newo cee.., an one or more sensors, suc as aoaoson rneraceevce, acceeromeer, or anoer senso n ssem sensor, comass,s sore one or meor seo srease oevr ac. ae sruc muaresn ocrunser auc maocnsne reae.a., seo mewaruem on wc uze an one or more oe meoooes orunconsescre emeon ornsrucons ma aso rese, comee or aeasara, wne ma ren.e wn sac memor , or wnerocessor urn execuonn meemor, comunevce.n an exame, one or an comnaon oeroce reo e memor,e sac memor, ore soraeevce ma consssor,e man mea. ue macne reaaeerm "macne reaeaee m meacunme" re maaanec mueeu am snes meusumrae or as a sne meum,e cenraze orsrueaaase, anor assocae ca mue meae.., a soree one or morensrucons. ces an serversa conureooncue anane meum eerm “macne reaae meum” ma asoeaen or execuon as caae o sorn, encon, or carrnnsrucons meoo e macne ana causee macneoerorm an one or more oe srucureso uesz oeer oesren assocscaoesure w or saucs cansaruce oon ss.orne, eenrcmo “nma ocr carrnaa meum” ma accorneaenoncue,u noemeo, so-s ne reaae oca an manec mea.ecc exames o macne-r ae memores, an voae memor,ncun, wa o exame, seeaae mea mancue non- ecrcarorammaeea-nemor mconucor memorevcese.., ttorneoceto.: aes a ,ecrca rasaerorammaeea-n emor remov ns mas memorevces manecss suc asnernaarss an eannserou-cooncsass m aanur-er aenr- ss. communcaons newor usn aran ansme or receve over a uzn an one o a num smsson meum vae neworneraceevce ec..xame co er oranserroocose..,rame rea,,,, , newor ,m amaucnceaoana n neewwoorrs mea..,nceunee arnoeca, m aroea neeweoerone ne,w ao wrse area ceuar newors,an eeone newors, an wreessaa n e.., . sanarsamnown as-, . sanarsamewornoswne. a.s, eaaexno,enecr-uo-ee aenrnan neweo mres, aummona oser csa.aeee orm s “orranns,m ensscon meum” sansruconsor execuon e macne, anncues a on or carrn snas or oernane meumoacae co or anao communcaons s useeren, a comonen, mam rmeuncaon o suc soware. avnounaresene uncon or surero aevce,sca en, orocecnooesaroveorearo oune cas,rancons,s, or oer conrouncons. nn or mouarzaon oarcuarrocessn oro carr ou a macnoemroonceensss. ma come coomnenne ma vae aeracneareacesu wnco onaera cromwaonens esneor use w oer comonens an aar o arorama usu re un arcuaruncon o reaeuncons.omonens ma c aerorms a comonense.., coe emoe on a macne onsue eer soware "arware comonen" -reaae meum orarware comonens. e conure or arranesn a a caenrane uns ccaaa maenn oer.erno vramronus c eexraamn oeemraoemnse an ma one or more comuer ssemse.., a sanaone com naons, or a server comuer ssem uer ssem, a cen comuer ssem, arocessor or arou oro ocre ossnoers or m maoreea crownareu creomon seonws oare a ceomuer sseme.., acaonoron as aarware comonena oer .., an acaon or escreeren. aesoerorm ceran oeraons as xames xame ttorneoceto.: aaase w carous a snu cesesc mroeecuearrennoremmaonosrae use o a cnca-enomcs ncun srucure commer n an varouseacare recors, ana caaer-camsaa.n varousnsances,enec muaon osersvaso wnas o couaeens wan oosseerva wonsr roesaaee coanc cerncoa oeseorvraons.sncues, eceorawanors ,o ‐roseomeraseen ano aernroen axanes oservaon o aeraonsnaens w ,ncun rsm m, an assesseorreuenc ansruon an comareo noe uaons oservn c measuremensoeermnee rae o moecuaece - crcuanumor c esn,reamenaer r aeraoneecon usn recevnvosnoown c -eece nsn a, an oucomesoraens oservvaaons, a emco.ns mua muaons.n varous,ere were surv onreuenc,umoruren,meo nexreamen, overa ae.osrerueevnaenaceereree-nesareneos-os,roesosos anrevraeenocse-axoasnes. ttorneoceto.: - aaxaenes..osreuennvuaene aeraonsreos- ,reos anreos- revaencere-aneosos osrevaenceos ttorneoceto.: ae:namcan c ttorneoceto.: x erena resoea nsm sesee o avearnacem wens vanrneerearemesen o oer avance ,aens ex namc moecuar canesn c oown sse aeuc ecac.nersann seuenareamen sraees an mcreamenss crucaornormn ese unme nees, weesne omzn oucomesoraens w m .ore aaaseo carace a sueveran a mu-nsuona cnca-enomcs uneron ssemrczeeeonuna moecuar canesn c naens w m aroaces anm ra, w e overarcnoa ounersonazereamen normaon an ser runo cvveunn reor csn conc mea mrreo ou rcac aeom aes a c. enca-enomcsaaase w c moecuar anassnaensanose wr r-camsaa,ereaeroowe muaon awanors ,o o‐sareo canceroeore an aernroeneceor re-reamen sames were seomerasenors , anaxanes. reamen sames w coece wnree monsrororeamen, weos- samenvua.eerea onn-anen weens arsesees mseones oerereanmceesnn mscuoanonnusa oonserrvoemree ttorneoceto.: anos-reamen. wo unerwen ceaerscnanosncreu- aenvuasanose w measacmnors ,o -ros nos-reamen w anroen receorawa c esn reore eomerasenors , anaxane cemoera. aeraons, anusonsn o un sonee nnuecs.eoe varans,nseronseeons, co numer xa re- anos-erem ar.mearer eanonosnre wseansoneeneaose- creaanmeesnn mmoeecounar, a neraonsene re-reamen wereaee as “newane.”c o reorenereamenmon,ure e versa, aeraons asenneos- “os.”econar enonsvonucsue re reoare-worn oeverrae-r seuarvmveanrwmeon wereaee asreamensconnuaonrw , an rea-w , rea-wormeo aens uneron c esn wnroeremeo nexreamenrw or measac casraon-ressan monsrecenrs-ne or ornes usnnc soaus, w aassero enesrmae ene cancereme.cnve onn.coee cnrcc ore oncoenc s muaons aserversnrosa a roe o anroen receor -r e cancer, we conuce a surou anasso evauae muaeoane aeraons,ncun amcaons an annnoman ,soownreamen w , , anaxanes. aeraons,ncun os- ream,en.ur, , , an , were aso assessere an suressorenes,ncunermore,, we e,x aanmnee, evoo avssnessanrosacaere oen ooereumor oownreame mcnsa oservere-anen. os-anrena-mennees was emoeo assesserencesn muaons amonaens recevnrs-n.eaan-ore mer curve.s wurereer co renssrouncseo evauae oucomes ase on muaon saus. ona,e as e sracaon wasone survva was examn socaoneween c uren an overao nors, were aes.o evauae revoe ersxonor meuaeronrse,v aaennocwen mecansm o ressance ttorneoceto.: x ncu raem- aneos- reamen:e mosreuen aereeneseore .eos- ,.e m,osoorweeu ., , , an ., ,en aer.ee,n aensncue.e., ., oserven ., ., an , weeresans were -.,oowe -., -., eaesosses weren ae an -. ure., ,omowonenvua a.era,ons, a amcaonaeesrevaencere- ., an amcaon..osmcaon., amcaon revaen.,o - , amcaon remanee mos amcaon., anowe amc aamcaon., ., amcaon. o on..eesans were seenn ., anowe amca amcaon., amcaon., a on..ereaesosses were oserven an mc aamon-., amcaon-., amcaon-., aecraaoonns:-.onu.rure,ae amcaonsncreaserom.re-er evauoao.n o, re aeraons,erevaence on.n os wearens.mone m ecn aann. an aoss aerao uaonsene,e mos commonre- .e.oaea.ns w,eoreo owseerven near a., muaons, exce.o, an , wearesncreases seenn . an ..er eece aoss o.n aso ,e m o an an.n .os- ..uorse.revaaeen- muaons remane . an oownenesrecer oaronnsre anos- :eraons were oserve amone , , , re,cnvo avnen.reos reamen: , aereenesre an monseme mosreuen . os-. o- were re-. os-.,oowe re- eneos anueoossn sren-.eenose- a.era won oe no ase.raoens weerse ttorneoceto.: waernes o wesreerv seeennn -..,, ., an . weereaesosses oa o novowuae aeraons w-er..ure,ae revaence o..sncrea eenere- , eac w a avne esresveaeonc aeraonsos- , w an revaenc e..e remann aeraons reane a ann.e o..o.ss oea.res waans w seaesnnn aeraons, re.ucn, we oer aeraons os- ure.ocusn on an ,re- rrevaenceo s anree aeraons , , an ,s on one aeraon ere was aoss o s an ae wereresen.os- , aeraon an new ae raons, w aan o one new . raons.ure.ae,uemenarae eneenomumc aorerauonresssnor seveenraesu :more s ssems an meosescreeren aso . exeees aera uressorenes,ncun , an era, w anncreaserom.on raoe a.mon, an a ae nneews m evuaauae,ore- anos-umor suressorenes aso so onan o..er mua wencrease aeraonreuencesos- . .oons.nc.reaseurerom,.aesre,- o.os- , an muaons roserom re rxea-m aneos- reamen:eoree amnsraon o ,e mos .uen, an aereenes. were. ,oowe ., ., ., .,e mos s.n,canansn.en,e a aneraons. were oserven eareso .n conras, oownsses weerreaenen -., -., an -.. ., .,,e mos.re,u aen aereenes seo ., eore reamen,ne mosrevae.n.ure.ae amcaon.,oowe .,nvua a.era,o an was amcaon .er , amcaon remanee mosreun ., w amcaon rsno.,oowe en. aera aonn ttorneoceto.: amca amonca.on an.. amec maoosn sn.can, waens were oserven -., amcaon-., ereaesosses occurren -..ure.a amcaon-., an rec ornr eeraonsre- anos- :eraons were oservenenes .monecese,nvoven wase, mncun , , , , an we ecamee mosr osreuen aereenere- ., onurer eveauuaenon a oereene anos- ..ncreaserom.o.os- , sow ,erevaence o o ecrease n aan o..n conras,erevaence revaence,ere wasro aman. o eoeve.nnosv-ua a.eraesonsensoesc-nen overa s sowneesrevaence..e numer o unue a wncreaseromre- oos- ,ouere wa eraonsn or ,re- aeraons s aoss o unue aeraons. arevaence o..os- n,cueree s an *, eac w aeraons, s an wa.s aan o.nwo aona unue aeraonsre- an oa, amon aensese seraor suesneoenaor ressaonsc-e meca,nsrmees eoxowne n reversoonn. muuarons, aes, e, eesos-mon oerrevaen-creeae.en.es,on saow,e a sn ecxanaen o a.., w resunn arevaence o. os- .o canesn an, oserveeweenre- anos- . revaence werencreaserom aa aseernaeonresv:aenonurer ev.auaaoesn o, aeraons, amcaon an o. an aoss o.ce o.re- o.os- , reecn a . weree mos. commmonon aee muaons, . an oserve acros raonsre- .ncanans were ..owesve servera muaons,arcuarn . an os- , ,osses we.re m aons noaen -. an -.. muaons.ure,aes, . remanee mosrevaen ttorneoceto.: suress umoruressorenes:eraons were oserven severaumor revaenocereonse-s,ncunreamen,, rsn,rom..eomonsrae a sncanncreasen mar, sowe a.an,ncreas ., reecn aan o . n conras, exe nsrevaencerom.o.os- . revaence o aoss o.,eano aos- revaence w no canes were oseerr. veeannese s:s, eversae oreormenees.umor suncreresassoereronmes, n.oaererevaence .os- , we aso roserom.o.. sowe a s-nconcreaserom.o.,ncanans were noen . an an ., wearesosses oserven -.,oow, ., . an oers. e - xraem- aneos-axaneream ,e mooosreuen aereeenne:sore- anos-axanereamenncue eesans anwoe , , an .osseecen sses- wereo asoo oservene sameenes weesan an - we -, - an aure,ae. reuen aeraonreer-a anons:os-oanxaunreer evauaon, amcaons remanee mos mon- muaons reamen, w aan o. an aoss o. re-axane aerao , an . weree mos common ., wnse.oes m-oasxanreo,n noouanceeoasnsess w oecrceu orreservnen -. an -., -..os-axane,e mos common muaon, ., ., an . ure s were umoruresso ,aes,. suressorenes,ncun ,rene,s a:nera.osn ssee wne wre oserve ann severaumor aees aeraon raere- anos-ax reamens, aan o .erumor su anes,ncreasnrom o, waxane. romo, arnessorenreosm aso soowe.ncareaesse, aeraonreuencesos- ttorneoceto.:nvoven ,ncueranonsre a,nos-axanes:eraons were oservenenes wase mosreuen aereene,o, , an .monese, resecve. an was noen re- anos-axane an , os-axaneaes,. o an , resunn a revaence x sames exeuacm woome rseesnaasns:osaee wns wow or uneere ccaeurennre-reamen aens wo unerwen c esnrorors- uren.mone,ncuene oucomes anass,ose w aenreaons soorw meea wsoarsec r mea-wor anm weeroe rwseaseror.es vsso.n.r,w.., an vs..,. v.s..,, rea-.wor.meo nexreamen xame unersoo cncam mcauaonosn-s. m e oncccouresn-α, oe caa ccas seusuen oave caoor osanoso-nases s.ass s areeeromersa ss caac suun α,, or, wc namese resun conss o a suun α, ,α,, orα.nuesc comex an a reuaornor eecs reeve as acvae re en ces, αsne .s omans on, resunn a ceorrosnenases snoe memra cvaon.nce acvae, ransocaesoe ce osanen aons convers osanoso ,-sosae no osoraes mo a,n, o-rsosae . en acvaes , wc , muaonsa smuaeer meaorsmaoveran cwea su arcvvva, arroewe, anrv mersr oaoun.n roresson. causn consuve acvaon o rr mor maveeen sowno snc esecve o usream snan, ere,e ssems an maeno enance ceroeraon. aens w a sescreeren were useor anass o au “uos,”va wncec seuenecsees c wrcua a nnexumenoeraon seuencn assa, aasma-ase varans,nseronseeons, amcaons, anursons on an u reoors oenne ssn we n auceoonae ttorneoceto.: reorn on mcaromsaees weernes aassessenwo an couomros.r mueaonauren aeraon, seamoresre.uenece amnorasrcus rs coorncueaens w muaons were assess aonna.sosr ausrsesesre an saexs aens, s aame.es wm esermou wereroue an comareoose w noeece -. ranes.so woere com vaareueso wre nruem coemr oar aeer uasnons aner un same w acoxon sne- resosor ,,., an mu, were are,wo-ae-es.ree m vs. - were aso aso evauae usn aser’sxaces. reore one assa w awo-se assseesrs’esxoarcreesuenc-va oue co a-noccuarrenceor aenes -vaue. sescoverae assess secc co- souccaunass assesse, sames.s coor was anaze manuao muaons an varansrr on unaneorwnns w sn excoannce an were remove. aeeraorsns. snonmous reuenc erences o aeraons exo anass assesse muaons excun “ non-ns m ouraones”w.eens an conuce on enes, secca vs. a vns.a sss was aso -.o-occurrence exons, exon, an samesames w an muaons were anaze w awo-seser’s ex w exon ese,. c oa reensus wse wre mae a aneraeo mneeaence ae w aear cec aveas.aesenor wa, sames. rane- ae. muaons wereenen. oaenss anears. o oe s raemmaensn muureaon c.assees mnacourn on- mruamaeo,nrs were mssense muaons., w wereoun across uncan, an sce muaons.uaons eesreueneene w a reuenc oenesn exons an ure . an c m muuaaoonnssnnc euxoen mnur eexon,. , , xame -mu -muae vs. - sames:ames wereroue as rs anass,aee numer om a oerraonser-n soameeec weere comare-.or comm saamrsones.nae a ttorneoceto.: sranneca-n vnsc.rea aseera nuomnsere or s aameraeonnseer same,- w aro mueraann aeraonser same -. scores were aso evauaeer e- an-vaue sncan er an - r.ou a.ne mem sames asoa a sames was. mu rane-, vs.. mu ranean or m envenors comare samereuences a-.n -. eween m vs. -.reso o muov weas secc reso an-cancer arova oemro examnease one was ex zuman measac soumors.reso o. mu reoreamne vaasuees onnaaaenrosm ws assa. sorwesno os vau meuoe we ercene o ranomzeaseaaemonsra as cosenase on eneromurva naoo aoves vaue wasrecve o . ere were sunmaca wn mreomreemumamn s mamcroessa aeovee s eaace mre oree,en – mu:. m: vs. so vs. - . -, mu .. m- vs... mu-:...m vs. xame rous were aso assess-emuoare co- vosc.cur - sames:e m vs. - enomce rn aeraons we oerenes reore on a w ecmoneseneusre..e, ma.or o. aereere wase annes ex scenocnan co-occurre wac a sn noca sn er assocaon w - =.,=. o, anm wcm onmec naona aessoecnea meu wa m. m vs.. -,ons enr.ce v ws..,mncu.e vs. . vs.., an . vs.. .., ex, we examneereu . susame o aensure .ences o an muaonsn a a a m.ners ana ns coor o, sames,. o sames sames an. o ms sasm, wee esx wamne a co-occu mrrunaons.ere were ae.rao on.oa non- muaons,ere were muaonsn. ooa s or muaonsn. o m sames. ames an co-occurrn ttorneoceto.: muaons envemnonrs e exxoanm,ne exoner,euenc o vs. non- oun sncan more co or mue mn exons an.e vs. non- -occurrn exon muaonsn sames exon muaons an c soammnese e=xo.n an.er meu waere smar raes o co-occurrn non- sam onseween an oun co-ocee crse. uarrere raes o muaons was oserve an reuences o co-occurernncen. o an ma ssaem ones.eraeesnvenors examneeneveomenarenese ae curren avaae an ann. o m saraons. wereounn. ooa sames sames an. o mm sesure . wereounn. ooa . o m sam ames. - wereounn. ooa sames an , erea,er a,es ne.nven-ors assroesse m exon as aoveor snc us. an emonsrae -an .erre.uenercee wse ore c noo-o sccnurrcnane exon muaons as comareo rou.or comne exon an muaonresn,ceseren was a sn exocnann mcureaaseonns nor vs. an--=.. ,u noerenceseween an xa venaure raesom oane uoocarcno oma s an aressve cancer w aoorronoss.oooen ssueoses,uosasecome anmoran muaons a acnonae mouescuonasr anerao anns.s o esamaessue-aseesnenes resecve.eres area ne ens w avance a , escre ene aror aernaveesn meosoeec . usn crcuaerennsumoereeconc o ceson measuree rae o moecuar aeraoneecon aens recevnvosnoown c ,-reeaecmeenae mrnusan aons., an oucomesor xame ttorneoceto.: comrses aea-woraa was sourcerom a rea wor evenceaaase, wc aens wr cenacea c commerceasnae ursnea a ceanmoms acneee-oene recorsrom , aens w a an reamen cam aer n assa,rom o . oucomes were as resus werencue= .aen meo nexreasmesesne vrwa rea-wo,r anm reea-oreamensconnuaonrw , rea-wor mons.o ranes was useo comareawoarn- oveeerra su srvurvvava curvrwes., a assessen xame omarer waseneanens w oae cns. aeraoneece, auene-recommene a an muaon, an uson,naens wnraeac n=, amcaon an uson.-esnee wcaes, muaon, era, aererms-neera a erormerorors-ne resecve. n aer secon-neeran, an oaens ,ceamcnea anne c asna cns rearensene,e an mo csa coemcmaonners-neera . common secon- weree mos mnoeneraes. era wnavosn-naveaens w an muaon, sare receve oeresra o c.aeness w: rece mveuavoonssrnea,e w recveove cemoera, numercamrove rw an rw comareoo snn=a rw:. :.-. vs. :.-. se recevn cemoeran= vs. :.- =..ere was n,o=.erenc rw . :.- recevnvosn vs no. en rweweenaens xam comaraeo reeor rae sero om acssuoen-aasee moesecnua.r aeraonseece va c s , sarnrs or seco aens w a are oeneseeorevosn ana an .aens w c -eece muaonsreae w cnc renowarmrove rw an rw .saa suorse eraa. u ouosoen a aens wo maeneromaree ttorneoceto.: reseneacns s maoueeer uonrmeresoon ana oreer annovr sumau saeneso uusse, anse meos oe remans oerae.urermore, soue unersooae on aseeacn reseneacns mancue an numer, or a, o aaraus an meos oe eeacn reman eescrememenaons, ason as arosu oerae. ere smemenaons o ssems,evces, an meosaveeenescre e snco.ee oseme cemaemneaonnvse anreonsv.en o snou wea a o erexcamaee, a mnor aeroev neor,naenee voam eaures oememenaonsaaveeenescre mae comnen v rous rouce numerous aonamemenaons.oreover arous waso mensons, saes, conuraons anoca , we varous maeras, scosememenaons, oers ons, ec.aveeenescreor use w e scoe oe camenvenoesesosescose mae uze wou exceen ma comrseeerwsoenrs oea ourresnarns an s. unsraee reenva ann arsn wv rueacomnzeemaenmaoenmeenaons aove.ememenaonsescreeren are no meanoe an ex scre oe wasn wce varouseaures mae comne. ausveresenaon are no muua excusve comnaons oea ccorn,ememenaons comnaon o erennvua ures raer,memenaons ma comrse amemenaons, as unersoo ereaures seecerom erennvua escre w reseco o sons o ornar sne ar.oreover, eemens even wen noes nememenaon maememenen oermemenaons eenen cam mcren sucmemenaons uness oerwse noe. ou a cams, o a reerne camso a secc comnaon w one or more oer suec maererm o eeamcen oaeornse maen aesno cncaume or a a co cmomnanaonon o oe onee oern meonre caeamu we oereenen orneenen cams.uc comnaons areroose res w saea a secc comnaons nonene.urermore, eren unesss eaures o a camn an oerneenen cam even snene asooncue eenenoen s cams norec mae oreeoveenr,e rne ceraem. memenaon,” or “somemnecmeennaones” s meecanscaoan aoar “ocnuearmeaeumree,n saruocnu,”re, “a onr ttorneoceto.: cmaraecmeernsaco,ne oscreeeanc connn.eceon a wearanceesm oemeenaron,sncuen aeas one varousacesne seccaon are no nec ase “n onememenaon”n nncororaon reerenecsesar a reerrnoe samememenaon. suec maersncororaeas conr oocumens aovesme suca noncororaon reerence oocumens aroe excscosureeren.nneocumens arencororae aovesurerme suca no camsncue ocumens aovese reerenceeren.nncororaon reerence o noncororae rurerme suca anenonsroveneocumens are oueere anncemereemne unnaesson exaresssncueeren. examememenaons, we evena veenescre w reerenceo secc maeoesememenaons wouearnarous mocaons an canes mae resenscosure.ccorn,e seccaromeroaer sr an scoe oe usrave raeran a resrcve sen on anrawns areoe rearen an sow, wa ousraon, an nse.e accomannrawnsaorm aarereo suec maer maeracce.oem oemmaon, seccmemenaonsn wce eao enaeose sene aroernaaonsusrae areescren sucenmemenaons mae uze anervececreeeeacnsscoseeren.er susuons an canes mae mae wouearom, suca srucura anoca seaeescron,ereore,s nooeaernrome scoe osscosure. varousmemenaonssene on e aennn amn sense, ane scoe o euvaenso wc e cams, aon weu rane o ou suc s ceams are ene. soue arecaeaccmemenaonsaveeenusrae anescreeren, susueore s an arranemen cacuaeo acevee sameurose mae an a aaa eccmemenaons sown.sscosuresneneo cover anmem ons or varaons o varousmemenaons.omnaons oe aoveoosee ona sons, an oermemenaons no seccaescreeren, we aaren nnes aroc uumonen re,vewenermse aoveescron. ocumens,oncue one "a" or "an" are use, ass commonnaen "aeas o or morean one,neenen o an oernsances or usaes o nonexcusvnee" or o,r su "cone oar " mo orer.""nncuseso "cumuen n,oe,"e "rm "uor" nos u,s"e ano " re aenro, a" ttorne oceto.: uneessa on-enrwsse enucvaaeen.sn oseo recsumeecnv,eeermersm "s "ncun" an "n wc" are use as oown cams,eerms "ncun" an " comrsn" an "weren." so,ne user eumen , arce, como comrsn" are oen-ene,as, a ssem, a onoosese aer son,ormuaon, orrocessancues eemensn a cam.oreover,ne souc aermn a cam are s eemeoa w ne scoe o use mere asaes, an are noownnen ceamos,meoseerm nusm "errsc,a" " rseecuornem,"e anns o "nre,r" o ece.c arse.

Claims

ttorne oceto.: as c aura o.am a me nenos: no crommarosnnro:m aaa reosor comrsn eecronc meca recors o reoso rrer oevnn,vorua onse or moreeura onvuas,aa sore a moecuaraa ene arnan, e comun ssem, a numer o eners. m.oe mne aonn oe anraerecaean re coam, comrsn: reu sroarn o aneasv auaors aonn oso aeer asn comrsn: mo aormoraoonn o oee n muemcear o recoerns oers.e one or .enerea mne aoa oa ane cormecersnn c aamu,r comrsn: uncon a orsoensenerae usn arsas ura , o wnerevn oune or more o eura orsoens corresono one or more o e senn as sore a moecuaraa reosor o eaaeo aeacareaa manaemen ssem aa corresaonnnn,roomeea aa manaemen ssem,n resonseoeaae,ea eneran, a nu omne oerr o moreea o eenuraers us onn a svecounasa an oens o e ura o rsoens corresonn o one ors muonrecon,or one or morenvuas. o e ura o oona an.ae coz m mne r ao o snoen c eaam rmnnonr,m coam onoenr o osn r ma: onreeorromon as oea as oneon a onaaa reosor,orouce a corus onormaon. anormaono remove .eerme mneno a ors an se oreceaanro ccaesms,n comnsrruscno:nsorrocessn e sore aeasttorne oceto.: oron eerm e o nxee acue onnorm roneao o arsn u srea o oaanrvoceusassnn wnsrcuc aonosoo acnaa cozneeonrsaa seo en ceornano ansrsreaseanse.ore on sresen an ooca e or more o eura onvuasn wc e .eerme mneno on oe o arn morreec aen cam, comrsn: e sore aeasoron o enormaona se oaarocessnnsruconsorrocessn or execun e one or more a onoan se oaarocessnnsruconso anaze one o mooreca a cononaon ses oreaaeermne aoron o aura onvuasn wc anvuaenserna wnc onee ors men ooore a c an a cononao snes oresaean.ore one or more o eura o .eerme mneno on o an recen cam, comrsn: onvuas. e or moreenomc muaonsresenne one or more o eura . e meo o more oeeermunran a ounr aan r v oece uasreanm cenam o, coonmsrrsovn:e ora caneroveo one or e.ermen mne sourv ova an raersecoerne c onaem o,r c moomrer osne:ura onvuas. reamene. se arnmen m ane en co oomrr o ces an mounaer onec ncee o on seu c oravm nev oa, c r m roam oer reesn ewnoe: menc a mrueaamoenns. o eura o e.erme mneno e ocac an orerecaemnen caorm,e comrr ssunse: o erou onvuas.ttorneoceto.: arr.anen meeon oer aanereacae renos caorm, w com arsunr:ocanseweeneura oaa a oaaaes an aura o ura oocansnc aes, werennvuaocans oeaesa corresono one ora mnore o ane oro mnaore ro rwosw os o an aaaae oeura oaa oaaaes. aonaaaae oeura or more.e meo o anrecen cam, wereneura oaaaesncue one aaaaaes seeceromerou conssn o: aaaaaea soresenomcsaa oeura onvuas eaca a soresaa reaeo one or moreaen vssnvuaso one or morenvu are asar waovae rers eseac soor oesnen oorr mmoareona corresonno resecve servcesroveoncae en vsso one or moreeacarerovers a aaaaaae se aecon ea sa aora sesa oreee srsonnaormnaormaon oeura onvuas overnm on reaeo aeansurance coman or aenaaa eane soran manoermaamoenn coorrre sserovncensroveoeura onvuas oreura oeansurance coveraenormaon rou o anaava o uaen s.av soureassn anormaon reaeoarmaceucareamens oane e so.rne mee ono o anrecen cam, comrsn: erormn oene or o mro mreoreaa se-rucenurescano annn oeerrmaeaeaa reosor moneneraeaa reosor. onseore,urn, anor aer aeas on.e ore m moereo o oe annomcrecneornma coanm, e, weenreomncen moormecauoanr,aeane reosor sores eenecnormaon, meaoomcnormaon,ranscromcnormaon,cranmoremnaomonc,ttorne oceto.:normao.n,m smune receornormaon, me aonnormaon, orroeomcnormaon. aura oannsenmo crommaronsnro:m aaa reosor comrsn eecronc meca recors o reoso rrer oevnn,vorua onse or moreeura onvuas,aa sore a moecuaraa ene arnan, e comun ssem, a numer o eners. mo. en ss aenmn oe arnaereacen cam, comrsn: sorn aeas aora roeno osoer comrsn: moreura onvuas an aeasn aormoraoonn o oee n muemcear o recoerns oers.e one or uncon,e wn.ereae ren ss n o aem nea o oa an r moer ceor omeceresnn c ur aam aur, oa com rs ors orns: enso coernrseseonneraoe on uesn arsas ura onvuas sore a moecua or more o e senn eaaeo aeacareraaa maa reosor oann,romeea aa manaemnaemen ssem aa corr en ssem,n resonseoeaae,ea eenseorannn, ao nu omne oerr o moreea o eenuraers us onn a svecounas an oens o e ura o rsoens corresonn o one oars muonrec oon,oer onuer or morenvuas. a o ana.zen s asem oon aannorermceanon c oaamn,e comrorms an: oona comrsn eermnn one or moreorons oea as oneon aanoonramaa reosor,orouce a corus onormaon. aono remove e.ee ssem o an recen cam, comrsn: oron ormennonrm aarosn se oaarocessnnsruconsorrocessn e sore aeasttorne oceto.: eerm enxee acuonrone o arsu srea o oaanrvoceusasnnsruconso anazeersaa seo ener sn wc aooca con onsresen an ooca conano ansrsreaseanse.ore one or more o eura onvuasn wc e e.ermen snse omne o or an morreec aenon caa sme, c oomarasnro: e sore cessnnsruconsorrocessn exe acueansoeron o enormaon or more a ona one or more a ona se oaarocessnnsruconso anaze one ooca con o se o aaeermne aoron o aura onvuasn wc a ener nsresen an nvuasna wnc onee or mooorec aa cononao snes oresaean.ore one or more o eura o e.ermen snse omne o or a mnorerecen cam, comrsn: onvuas. enomc muaonsresenne one or more o eura . e ssem o an rece more oeeermunran a ounrav ouasreanme cna om, coonmsrrosvne: ora caneroveo one or e.ermen snse smurv ov aan rareesceorne c oanem o,r c momorer osn:eura onvuas. eamene. se arnmen s anse en cm oomr orces an mounr aee onc ncee o on s c euam, comrsn: r orvnev oar m raoereeewnoemenc a mrueaamoenns. o eura o e.erme snnsem e oca acn orerceeamnen caomr, ceomrrs suns:e o erou onvuas.ttorne oceto.:oca arnr.ane sn ss eweeem enn oe a ernaere uraacea r oeno csa aom ar, a w com es, ars wunra: oaaaes an aura o ura oocansncan one or erennvuaoca ns o eaesa corresono one or more a o mnaore ro rwosw os o an a aaaonaaea oaaee ourae oaa oaaaes. ura or morea.aae sesse smee oce an recen cam, wereneura oaaaesncue one aaaaea soresromenomecrsou conssn o: aaaa soresaa reaeo onea oa o eura onvuas eacarer r moreaen vss nvuaso one or morenvu aasa waovae rers eseac soor oesnen oorr mmoareona coernres vosnsno oone re osre mcovree seeravcecsarerovroveoncae e secon aaa ers a aaaaaaaeea saor sesoreee srsonnaornormaon o eura onvuas overnmena en a maeamenmoar soenrv rceeaserovoe aoeaeunrsauran oce coman or aaaae sornnormaon corresonnoea nvuas oreura onvua nsurance coveraenormaon rou o anaavauaes.a soressn anormaon reaeo armaceucareamens oane e so.rne ses oenme o or m anorereacaen cam, comrsn: erormn o srucuresn annermeaeaa reosor mo n eneranee oraa m roereoseo-re.ncaon oeraonseore,urn, anor aer eas one. or me sorese om oen aonmcrecneornma caonm,, e weernene moecuaraa reosor sores a e enecnormaon, meaoomcnormaon,raonmsccrnomormcanoonr,maenoecnormaon,normaon,mmune receornormaon, me aonnormaon, orroeonm,cranmoremnaomonc.ttorneoceto.: execuae.nsneru ocro mnosreo noenr-orramns ooerra comuer-reaae sorae mea sorn comuer- oannnormaonrom aaao renso comrsn: aura sor comrsn eecronc meca recors o reoso rrer oevnn,vorua onse or moreeura onvuas,aa sore a moecuaraa ene arnan, e comun ssem, a numer oeners. comrs.e one or more non-ransor comuer-reaae mea o anrecen cam, mno:n moreu sro a arnnn o ae neraase v aa uaora r s aoe nno oso aeer asn co aomrmorars oon nn o o: ee n muemcear o recoerns oers.e one or comrsn.e one or more non-ransor comuer-reaae mea o anrecen cam, uncon,e wne:rearenn o anea oar moer ceo omresnur aaur oars oorsenso coernrseenerae usn arsas ura onvuas sore a sono one or more oe senneaaeo aea moceacruaraa reosor cor orann,romeeaaa meaa manaemen ssem aa anaemen ssem,n resonseoeaae,ea eenseorannn, ao nu omne oerr o moreea oeenuraers us onn a sveuas an oens oeura orsoens corresonnoco onne oars muonrec oon,oer one or morenvuas. ura o comrs.e one or more non-ransor comuer-reaae mea o anrecen cam, oona anna: cozmnr asnonanormaon oanerom aeas one aonaaa reosor,orouce a corus oneoerrmmanonn. one or moreorons o aonanormaono removettorne oceto.: comrsn. e one or more non-ransor comuer-reaae mea o an recen cam, oronee:rmnn ars se oaarocessnnsruconsorrocessn e sore aeas eerm e o nxee acue onnorm roneao o arsn u srea o oaanrvoceusassnn wnsrcuc aonosoo acnaa cozneeonrssreasea seo eneran asrsreaseanse.ore one or mo n an ooca con on re o eura onvuasn wc e comrsn. e one or more non-ransor comuer-reaae mea o an recen cam, e soree ae:rmeansno ornoen o or moeren aormaonoan se oaarocessnnsruconsorrocessn or more ex aecunonae se on oe ora maoree aermnoena a seor oona oa arocuesrsnnsruconso anaze one ooca con onsresen a onvuasn wc anvuaenserna wnc onee or mooore a c an a cononao snes oresaean.ore one or more o eura o comrsn. e one or more non-ransor comuer-reaae mea o an recen cam, onveue: arms.nn one or moreenomc muaonsresenne one or more o eura comrsn. e one or more non-ransor comuer-reaae mea o an recen cam, more oeee:rmunran a ounrav ouasreamen oonsrove ora caneroveo one or comrsn.:e one or more non-ransor comuer-reaae mea o an recen cam,ttorneoceto.: eermnn survva raesore one or more oeura onvuas. comrsn.e one or more non-ransor comuer-reaae mea o anrecen cam,reamenese: arnmn anen coomrrces mounaeonnce o o seu orvnev oar m raoereeewnoemenc a mrueaamoenns. oeura o comrsn.e one or more non-ransor comuer-reaae mea o anrecen cam, ee:rmnn ecac oreamenorer suse oerou onvuas. comrsn.e one or more non-ransor comuer-reaae mea o anrecen cam,oca arnra:nsneweeenneeraeuraaa r oeosor w aura oaaaes an aura o ura oocans aaaes, werennvuaocans oeaesa corresono onne ocra mnore o ane oro mnaore ro rwosw os o aaaae oeura oaa oaaaes. an aonaaaae oeura weren.eeu orane or o moarea noan-ersannscoure c oonmuer-reaae mea o anrecen cam, conssn o e or moreaaaes seeceromerou a aaaaa:aae soraes soareas reeaneomocs onea oar o moreeaurean v osnvuas eacarer snvuaso one or morenvu aasa waovae rers eseac soor oesnen oorr mmoareona coernres vosnsno oone re osre mcovree seeravcecsarerovroveeroncae e seconaaae s a aaaaaaaeea saor sesoreesrsonanormaon oeura onvuas overnmena en a maeamneonrmoar soenrv rceeaserovo aeansurance coman or aaaae sornnormaon corresonnoeaeonsuerancuera cove oraennvormuaasonttorneoceto.: ore rou o aur naaava o uaen s.av soureassn anormaon reaeoarmaceucareamens oane e comrs.e one or more non-ransor comuer-reaae mea o anrecen cam, sn eor:ne one or moreaa srucuresn annermeaeaa reosor monroremnner oanee oraa m roereoseo-re.ncaon oeraonseore,urn, anor aer weren.e meo one or more non-ransor comuer-reaae mea o anrecen cam, eenomcnoecrmuaarona,a reeosor sores aeas one or more oenomcnormaon,normaon,ranscromcnneorcmanoonr,maraonm,e eenecnormaon, meaoomcnormaon, meaonnormaon, orroeomcnnoomrmcaonn.ormaon,mmune receor

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