Light irradiation device

Abstract

A light irradiation device according to the present disclosure comprises an elongated tubular body and an outer cylindrical body that covers the outside of the tubular body in the radial direction. The tubular body is provided with: a first light transmissive window part that is disposed only in a portion of the tubular body in the circumferential direction; and a first light blocking part that is adjacent to the first light transmissive window part in the circumferential direction and has a lower transmittance than that of the first light transmissive window part. The outer cylindrical body is provided with: a second light transmissive window part that is disposed only in a portion thereof in the circumferential direction at a position where at least a portion of the second light transmissive window part overlaps a portion of the first light transmissive window part in the direction of the central axis of the tubular body; and a second light blocking part that is adjacent to the second light transmissive window part in the circumferential direction and has a lower transmittance than that of the second light transmissive window part.

Description

Light irradiation device

[0001] The present disclosure relates to light illumination devices.

[0002] Phototherapy devices used to irradiate abnormal tissue with therapeutic light are known. Patent Document 1 describes this type of phototherapy device. The phototherapy device described in Patent Document 1 includes a balloon having a defined treatment window that delivers irradiation to a defined area. The treatment window of the balloon in Patent Document 1 is defined by coating the periphery with a reflective material.

[0003] Japanese Patent Application Laid-Open No. 2005-46640

[0004] The balloon in Patent Document 1 is deflated when inserted into or removed from a lumen such as a biological lumen. In the phototherapy device described in Patent Document 1, a reflective material is coated only on the balloon, thereby defining a treatment window as a light-transmitting window portion that is not coated with a reflective material and a light-blocking portion that is coated with a reflective material. When a reflective material is coated only on the balloon to achieve a predetermined light-blocking performance using the balloon alone, the thicker the coating on the balloon, the higher the light-blocking performance, which tends to result in a thicker balloon. Therefore, even when the balloon as an expandable body is deflated, its diameter may not be sufficiently reduced. In such cases, the sliding resistance between the deflated balloon and the inner surface of the biological tissue defining the lumen or the inner surface of a moving channel within an elongated medical instrument placed in the lumen increases, potentially reducing the balloon's insertability.

[0005] An object of the present disclosure is to provide a light irradiation device having a light-transmitting window portion and a light-shielding portion, which can realize a small diameter when inserted into a body lumen.

[0006] A light irradiation device according to a first aspect of the present disclosure includes: (1) a long tubular body that defines an accommodation space therein that accommodates or can accommodate a light irradiation unit; and an outer cylindrical body that covers the outside in a radial direction of the tubular body and is expandable and contractible in the radial direction, wherein the tubular body includes: a first light-transmitting window portion that is arranged only in a part of the circumferential direction of the tubular body and that allows light from the light irradiation unit accommodated in the accommodation space to pass outward in the radial direction; and a first light-shielding portion that is adjacent to the first light-transmitting window portion in the circumferential direction and has a transmittance in the radial direction outward of light from the light irradiation unit accommodated in the accommodation space that is lower than the transmittance of the first light-transmitting window portion, and the outer cylindrical body includes: a second light-transmitting window portion that is arranged only in a part of the circumferential direction at a position that at least partially overlaps with the first light-transmitting window portion in the central axis direction of the tubular body and that allows light from the light irradiation unit accommodated in the accommodation space to pass outward in the radial direction, a second light-shielding portion that is adjacent to the second light-transmitting window portion in the circumferential direction and has a transmittance of light from the light-irradiating portion accommodated in the accommodation space to the outside in the radial direction that is smaller than the transmittance of the second light-transmitting window portion.

[0007] A light irradiation device according to one embodiment of the present disclosure is (2) the light irradiation device according to (1) above, in which the first light-transmitting window portion and the second light-transmitting window portion are arranged at positions where they at least partially overlap each other in the circumferential direction.

[0008] A light irradiation device according to one embodiment of the present disclosure is (3) the light irradiation device according to (2) above, in which an extension angle of the first light-transmitting window portion, expressed as a central angle around the central axis of the tubular body, is equal to or greater than an extension angle of the second light-transmitting window portion, expressed as a central angle around the central axis of the tubular body, and the first light-transmitting window portion is arranged at a position overlapping in the circumferential direction with the entire circumferential area of ​​the second light-transmitting window portion.

[0009] A light irradiation device according to one embodiment of the present disclosure is the light irradiation device according to any one of (1) to (3) above, wherein: (4) an extension angle of the second light-shielding part, expressed as a central angle around the central axis of the tubular body, is equal to or greater than an extension angle of the first light-shielding part, expressed as a central angle around the central axis of the tubular body; and the second light-shielding part is disposed at a position overlapping in the circumferential direction with the entire circumferential area of ​​the first light-shielding part.

[0010] A light irradiation device according to one embodiment of the present disclosure is (5) the light irradiation device according to any one of (1) to (4) above, wherein the transmittance of the second light-shielding part for the light from the light-irradiating part is lower than the reflectance and the absorptance of the second light-shielding part for the light from the light-irradiating part.

[0011] A light irradiation device according to one embodiment of the present disclosure is (6) the light irradiation device according to (5) above, in which the reflectance of the first light-shielding part for the light from the light-irradiating part is greater than the transmittance and the absorptance of the first light-shielding part for the light from the light-irradiating part.

[0012] A light irradiation device according to one embodiment of the present disclosure is (7) the light irradiation device according to (6) above, in which the transmittance of the second light-shielding part for the light from the light irradiation part is lower than the transmittance of the first light-shielding part for the light from the light irradiation part.

[0013] A light irradiation device according to one embodiment of the present disclosure is (8) the light irradiation device according to (7) above, in which a reflectance of the first light-shielding part for the light from the light-irradiating part is greater than a reflectance of the second light-shielding part for the light from the light-irradiating part.

[0014] A light irradiation device according to one embodiment of the present disclosure is (9) the light irradiation device according to any one of (1) to (8) above, wherein the first light-shielding portion extends in the circumferential direction from a position adjacent to one end of the first light-transmitting window portion to a position adjacent to the other end of the first light-transmitting window portion.

[0015] A light irradiation device according to one embodiment of the present disclosure is (10) the light irradiation device according to any one of (1) to (9) above, wherein the second light-shielding portion extends in the circumferential direction from a position adjacent to one end of the second light-transmitting window portion to a position adjacent to the other end of the second light-transmitting window portion.

[0016] A light irradiation device according to one embodiment of the present disclosure is (11) the light irradiation device according to any one of (1) to (10) above, wherein the outer cylindrical body is an expandable body that can be changed from a contracted state to an expanded state.

[0017] (12) A light irradiation device according to one embodiment of the present disclosure is the light irradiation device according to any one of (1) to (11) above, wherein, when the tubular body is a first tubular body, a second tubular body is provided that covers the radial periphery of the first tubular body, and the outer cylindrical body is fixed to the outer surface of the first tubular body and the outer surface of the second tubular body, straddling the outer surface of the first tubular body and the outer surface of the second tubular body.

[0018] According to the present disclosure, it is possible to provide a light irradiation device having a light-transmitting window portion and a light-shielding portion, which can realize a reduction in diameter when inserted into a body lumen.

[0019] 2 is a diagram illustrating an example of an endoscope system including a light irradiation device according to an embodiment of the present disclosure, and is a diagram illustrating the light irradiation device shown in FIG. 1. FIG. 3 is a cross-sectional view of the light irradiation device taken along line II in FIG.

[0020] Hereinafter, embodiments of the light irradiation device according to the present disclosure will be described with reference to the drawings, in which the same components are designated by the same reference numerals.

[0021] FIG. 1 is a diagram illustrating an example of an endoscopic system 100 including a light irradiation device 1 as an embodiment of a light irradiation device according to the present disclosure. The endoscopic system 100 illustrated in FIG. 1 includes an endoscopic apparatus 101, a control device 102 connected to the endoscopic apparatus 101, a display unit 103 such as a monitor connected to the control device 102, a light source apparatus 104, and the light irradiation device 1. The endoscopic apparatus 101 is provided with a treatment instrument channel through which the light irradiation device 1 serving as a treatment instrument can be inserted. As illustrated in FIG. 1 , the light irradiation device 1 is inserted into the treatment instrument channel of the endoscopic apparatus 101 and delivered to a lesion in an inner cavity. The control apparatus 102 includes a light source unit 102a that supplies illumination light to the endoscopic apparatus 101 and a processor unit 102b that performs various image processing on an image signal from the endoscopic apparatus 101 to convert it into a video signal. The control apparatus 102 may also include an input unit such as a keyboard. The display unit 103 can display an image captured by the endoscope device 101 based on a video signal generated by the processor unit 102 b of the control device 102 .

[0022] The light irradiation device 1 can be used for, for example, photodynamic therapy (PDT) and photoimmunotherapy (PIT). In this embodiment, the light irradiation device 1 is used in photoimmunotherapy, which destroys target cells by irradiating light onto a drug adsorbed on target cells, as taught in Japanese Patent No. 6127045. The target cells are tumor cells, such as cancer cells or cells of precancerous lesions. In this treatment method, a photosensitizer is used as the drug, which comprises an antibody that specifically binds only to a unique antigen on the surface of tumor cells and a photosensitizer that pairs with the antibody. The antibody is not particularly limited, but examples include panitumumab, trastuzumab, HuJ591, pertuzumab, lapatinib, palbociclib, and olaparib. The photosensitizer is, for example, but not limited to, hydrophilic phthalocyanine, a substance that responds to near-infrared light with a wavelength of approximately 700 nm (IR700). When IR700 is exposed to near-infrared light with a wavelength of approximately 660 to 740 nm, the ligands of the functional groups that ensure its water solubility are cleaved, causing a structural change from water solubility to hydrophobicity. This structural change pulls out membrane proteins, creating holes in the cell membrane and allowing water to enter the cell, thereby rupturing and destroying tumor cells. Furthermore, IR700 is excited by near-infrared light and emits fluorescence with a wavelength different from the excitation wavelength. For example, when IR700 is excited by near-infrared light with a wavelength around 690 nm, it emits fluorescence with a wavelength around 700 nm. IR700 undergoes a structural change while emitting fluorescence due to a photoreaction, and ceases to emit fluorescence once it has destroyed tumor cells and fulfilled its role as a drug. The light irradiation device 1 can be inserted into a cavity such as a biological lumen. The light irradiation device 1 may be used together with an endoscope device 101, as shown in FIG. 1 . However, the light irradiation device 1 does not necessarily have to be used together with the endoscope device 101. There is no particular limitation on the cavity into which the light irradiation device 1 can be inserted. As shown in Fig. 1 , the light irradiation device 1 may be used, for example, for treating gastrointestinal cancer through a treatment instrument channel of an endoscopic apparatus 101 inserted into a hollow organ such as the gastrointestinal tract (e.g., esophagus, stomach, small intestine, large intestine), urinary tract, or blood vessel.In this embodiment, the light irradiation device 1 is used in photoimmunotherapy, which involves irradiating a drug adsorbed on target cells with light to destroy the target cells, as taught in Japanese Patent No. 6127045. The target cells are tumor cells, such as cancer cells or cells of precancerous lesions. In this treatment method, a photosensitizer is used as the drug, which comprises an antibody that specifically binds to a unique antigen on the surface of tumor cells and a photosensitizer that pairs with the antibody. The antibody is not particularly limited, but examples include panitumumab, trastuzumab, HuJ591, pertuzumab, lapatinib, palbociclib, and olaparib. The photosensitizer is, for example, but is not limited to, hydrophilic phthalocyanine, which is a substance that responds to near-infrared light with a wavelength of approximately 700 nm (IR700). When IR700 is exposed to near-infrared light with a wavelength of approximately 660 to 740 nm, the ligands of the functional groups that ensure its water solubility are cleaved, causing a structural change from water solubility to hydrophobicity. This structural change pulls out membrane proteins, creating holes in the cell membrane and allowing water to enter the cell, rupturing and destroying tumor cells. IR700 is also excited by near-infrared light and emits fluorescence with a wavelength different from the excitation wavelength. For example, when IR700 is excited by near-infrared light with a wavelength around 690 nm, it emits fluorescence with a wavelength around 700 nm. IR700 undergoes a structural change while emitting fluorescence due to a photoreaction, and once it has destroyed tumor cells and fulfilled its role as a drug, it ceases to emit fluorescence.

[0023] Fig. 2 is a diagram showing the light irradiation device 1. As shown in Fig. 2, the light irradiation device 1 of this embodiment includes a long first tubular body 10 and a second tubular body 20, and an expandable body 30 serving as an outer cylindrical body arranged to cover the outside of the first tubular body 10. Fig. 2 is a cross-sectional view of the light irradiation device 1 taken along a cross section passing through the central axis O of the first tubular body 10 and parallel to the central axis O.

[0024] Hereinafter, in the light irradiation device 1, the direction along the central axis O of the first tubular body 10 will be referred to as the central axis direction A. Furthermore, in the light irradiation device 1, the direction of the central axis direction A from the proximal side to the distal side will be referred to as the insertion direction A1, and the direction of the central axis direction A from the distal side to the proximal side will be referred to as the removal direction A2. Furthermore, in the light irradiation device 1, the direction around the central axis O of the first tubular body 10 will be referred to as the circumferential direction B. Furthermore, in the light irradiation device 1, the radial direction of an imaginary circle centered on the central axis O of the first tubular body 10 will be referred to as the radial direction C.

[0025] First, an example of a method of using the light irradiation device 1 will be described. Prior to treatment using the light irradiation device 1, a photosensitive substance is administered into the body. The method of administering the photosensitive substance into the body is not particularly limited as long as it can reach tumor cells. For example, it may be intravascular administration, which in this embodiment is intravenous administration. Approximately 12 to 36 hours after intravenous administration, light irradiation treatment using the light irradiation device 1 of this embodiment is performed. A light irradiator 201 (described later) is inserted into the first tubular body 10 of the light irradiation device 1, and a light irradiation unit 200 (provided at the distal end of the light irradiator 201 in the central axis direction A) is positioned at a predetermined position within the first tubular body 10. A hub 40 (described later) includes a hub main body 41 and a connecting portion 42. The connecting portion 42 of the hub 40 holds the light irradiator 201 so as to surround it. The light irradiator 201 may be fixed to the light irradiation device 1 by rotating and screwing the connecting portion 42 relative to the hub body 41 while inserted into the first tubular body 10 of the light irradiation device 1. Conversely, the light irradiator 201 can be removed from the first tubular body 10 of the light irradiation device 1 by unscrewing the hub body 41 and the connecting portion 42. In this embodiment, the light irradiator 201 includes a light irradiation unit 200 provided at the distal end in the central axis direction A and a light transmission member 202 such as an optical fiber connected to the light irradiation unit 200 and extending toward the proximal end in the central axis direction A. The proximal end of the light transmission member 202 is connected to the light source device 104. For example, the light irradiator 201 may be configured with a side-emitting optical fiber capable of irradiating light circumferentially outward in the radial direction C at the distal end. Furthermore, the expansion body 30 of the light irradiation device 1 is in a contracted state in this state.

[0026] Next, the light irradiation device 1 and the light irradiator 201 fixed to the light irradiation device 1 are inserted into a living body through the treatment tool channel of the endoscope apparatus 101 (see FIG. 1 ). At this time, the position of a second light-transmitting window portion 31 (described later) in the expandable body 30 is aligned in the central axis direction A and the circumferential direction B with the position to be irradiated, such as a lesion formed in the biological tissue that defines the lumen. Alignment in the central axis direction A is performed by moving the light irradiation device 1 in the insertion direction A1 or the removal direction A2. Alignment in the circumferential direction B is performed by rotating the light irradiation device 1 in the circumferential direction B.

[0027] Next, the expandable body 30 is expanded from the contracted state. The expandable body 30 may be expanded in two stages, for example, an adjustment expanded state in which light irradiation to the irradiation target is not performed, and a treatment expanded state in which the internal pressure is higher than in the adjustment expanded state and light irradiation to the irradiation target is performed. The adjustment expanded state of the expandable body 30 may be used to fine-tune the alignment of the position of a second light-transmitting window portion 31 (described later) in the expandable body 30 with the position of the irradiation target in the central axis direction A and the circumferential direction B.

[0028] By placing the expandable body 30 in a therapeutic expanded state (hereinafter simply referred to as the "expanded state"), the second light-transmitting window portion 31 (described later) of the expandable body 30 is brought into close contact with the irradiation target. In this state, the irradiation target can be irradiated with light that is emitted from the light irradiating unit 200 and passes through the second light-transmitting window portion 31 outward in the radial direction C. The irradiation time for the irradiation target is not particularly limited, but may be, for example, several minutes to several tens of minutes.

[0029] After the treatment is completed, the expansion body 30 is contracted, and the light irradiation device 1, together with the light irradiator 201, is removed from the living body through the treatment instrument channel of the endoscope apparatus 101 (see FIG. 1).

[0030] Next, the light irradiation device 1 will be described in detail with reference to Figures 2 and 3. Figure 3 is a cross-sectional view of the light irradiation device 1 taken along line II in Figure 2.

[0031] As shown in FIGS. 2 and 3 , the first tubular body 10 defines an internal storage space 10a that contains or can contain a light irradiation unit 200. More specifically, the first tubular body 10 of this embodiment can contain the light irradiation unit 200 included in a light irradiator 201 that is separate from the light irradiation device 1. The light irradiator 201 may include the light irradiation unit 200 that emits light outward in the radial direction C and an optical transmission member 202 such as an optical fiber that transmits light from the light source device 104 (see FIG. 1 ) to the light irradiation unit 200. The light irradiation unit 200 and the optical transmission member 202 can be configured to have the same diameter throughout the entire central axis direction A of the light irradiation device 1. In the light irradiator 201 of this embodiment, the light irradiation unit 200 is attached to the distal end of the optical transmission member 202. The light irradiation unit 200 of the light irradiator 201 can be inserted into the accommodation space 10a in the insertion direction A1 from a proximal opening 10a1 of the accommodation space 10a located at the proximal end of the first tubular body 10. More specifically, the light irradiator 201 is inserted into the accommodation space 10a in the insertion direction A1 to a set position where the light irradiation unit 200 overlaps with a first light-transmitting window portion 11 (described later) of the first tubular body 10 in the central axis direction A. As shown in FIG. 2 , the distal side of the accommodation space 10a in this embodiment is closed. In the light irradiation device 1 and light irradiator 201 of this embodiment, the set position is achieved by abutting the distal end of the light irradiator 201 against a closing wall 15b on the distal side of the accommodation space 10a of the first tubular body 10. The distal side of the accommodation space 10a of the first tubular body 10 is not closed by the closing wall 15b, and may have a stepped surface facing the proximal side, reducing its diameter. In such a case, the distal end of the light irradiator 201 may be brought into contact with the step surface to achieve the set position.

[0032] The light irradiation section 200 may be provided in the accommodation space 10a of the first tubular body 10. In other words, the light irradiation device 1 may be configured to include the light irradiation section 200 accommodated in the accommodation space 10a.

[0033] The intensity and wavelength of the light emitted from the light irradiating unit 200 may be appropriately selected depending on, for example, the condition and position of the lesion. The light emitted from the light irradiating unit 200 may be, for example, visible light such as near-infrared light.

[0034] As shown in Fig. 3, the first tubular body 10 includes a first light-transmitting window 11 and a first light-shielding portion 12. The first light-transmitting window 11 and the first light-shielding portion 12 are arranged in a position in the central axis direction A where they at least partially overlap with a second light-transmitting window 31 and a second light-shielding portion 32 (described later) of the expansion body 30. The first light-transmitting window 11 is arranged in only a portion of the circumferential direction B of the first tubular body 10. The first light-transmitting window 11 is configured to allow light from the light irradiation unit 200 housed in the housing space 10a to transmit outward in the radial direction C. The first light-shielding portion 12 is arranged adjacent to the first light-transmitting window 11 in the circumferential direction B. The transmittance of the first light-shielding portion 12 to the outside in the radial direction C of light from the light-irradiating portion 200 housed in the storage space 10a (hereinafter simply referred to as the "transmittance of the first light-shielding portion 12") is smaller than the transmittance of the first light-transmitting window portion 11 to the outside in the radial direction C of light from the light-irradiating portion 200 housed in the storage space 10a (hereinafter simply referred to as the "transmittance of the first light-transmitting window portion 11").

[0035] In this embodiment, as shown in Fig. 3, the first light-transmitting window 11 and the first light-shielding portion 12 of the first tubular body 10 are realized by a layered relationship between a transmissive layer 90a and a light-shielding layer 90b. Specifically, the first tubular body 10 of this embodiment includes a transmissive layer 90a located on the inside in the radial direction C and a light-shielding layer 90b located on the outside in the radial direction C. The transmissive layer 90a is configured to allow light from the light irradiator 200 housed in the accommodation space 10a to transmit outward in the radial direction C. The light-shielding layer 90b is configured so that the transmittance of light from the light irradiator 200 housed in the accommodation space 10a to the outside in the radial direction C is smaller than the transmittance of the transmissive layer 90a. The first light-transmitting window 11 of the first tubular body 10 of this embodiment is configured only by the transmissive layer 90a, without the light-shielding layer 90b being layered on the transmissive layer 90a. In contrast to this, the first light-shielding portion 12 of the first tubular body 10 of this embodiment is configured by laminating a light-shielding layer 90b on a transmissive layer 90a.

[0036] The first tubular body 10 of this embodiment includes a tube main body 13 and a coating film 14 applied to the outer surface of the tube main body 13. The transmissive layer 90a of this embodiment corresponds to the tube main body 13. The light-shielding layer 90b of this embodiment corresponds to the coating film 14. The method for applying the coating film 14 to the tube main body 13 of this embodiment is not particularly limited. The coating film 14 may be applied to the tube main body 13 by, for example, dipping, spray coating, roll coating, screen printing, vacuum deposition, low-vacuum sputtering, or the like. However, the transmissive layer 90a and the light-shielding layer 90b are not limited to the configuration of this embodiment. For example, the transmissive layer 90a and the light-shielding layer 90b do not have to be laminated on top of the transmissive layer 90a. The transmissive layer 90a and the light-shielding layer 90b of the first tubular body 10 may be integrally molded by multicolor extrusion molding or the like, so that the transmissive layer 90a and the light-shielding layer 90b are formed as a single layer and are located at the same position in the radial direction C.

[0037] In addition, although the coating film portion 14 serving as the light-blocking layer 90b in this embodiment is laminated on the outer surface of the tube body portion 13 serving as the light-transmitting layer 90a, this configuration is not limiting. The light-blocking layer 90b may also be laminated on the inner surface of the light-transmitting layer 90a.

[0038] The transparent layer 90a may be made of, for example, a transparent resin. Examples of transparent materials that make up the transparent layer 90a include polyolefins such as polyethylene, polypropylene, and ethylene-propylene copolymers; ethylene-vinyl acetate copolymers (EVA); polyvinyl chloride; polyvinylidene chloride; polystyrene; polyamide; polyimide; polyamideimide; polycarbonate; poly-(4-methylpentene-1); ionomers; acrylic resins; polymethyl methacrylate; acrylonitrile-butadiene-styrene copolymers (ABS resins); acrylonitrile-styrene copolymers (AS resins); butadiene-styrene copolymers; and polyethylene terephthalate. Examples of the resin material include various resin materials such as polyesters such as poly(ethylene terephthalate) (PET), polybutylene terephthalate (PBT), and polycyclohexane terephthalate (PCT); polyether; polyether ketone (PEK); polyether ether ketone (PEEK); polyetherimide; polyacetal (POM); polyphenylene oxide; modified polyphenylene oxide; polysulfone; polyether sulfone; polyphenylene sulfide; polyarylate; aromatic polyester (liquid crystal polymer); polytetrafluoroethylene, polyvinylidene fluoride, and other fluorine-based resins. Blends containing one or more of these may also be used. The resin material need only be transparent to the wavelength of the irradiated light, and need not be transparent to visible light.

[0039] The light-shielding layer 90b may be made of any material as long as it has a lower transmittance of light from the light irradiating unit 200 than the transmissive layer 90a. Examples of light-shielding materials that can be used to make the light-shielding layer 90b include various metal materials such as titanium oxide, barium sulfate, zinc oxide, silver, and aluminum. The light-shielding layer 90b may also be made of a resin containing particles of the above-mentioned metal materials, carbon black, or the like.

[0040] In this way, light from the light irradiation unit 200 accommodated in the accommodation space 10a of the first tubular body 10 is emitted to the outside in the radial direction C of the first tubular body 10 mainly through the first light-transmitting window portion 11 provided in only a part of the circumferential direction B. In other words, by providing the first light-transmitting window portion 11 in only a part of the circumferential direction B, the first tubular body 10 has optical directivity in which light emitted to the outside in the radial direction C from the accommodation space 10a of the first tubular body 10 is mainly limited to a part of the circumferential direction B.

[0041] The expandable body 30 covers the outside of the first tubular body 10 in the radial direction C and is configured to be expandable and contractible in the radial direction C. Specifically, the expandable body 30 of this embodiment is a balloon made of a membrane body that covers the periphery of the first tubular body 10. The balloon as the expandable body 30 of this embodiment defines an annular fluid storage space 30a between itself and the outer surface of the first tubular body 10. The expandable body 30 of this embodiment is expandable outward in the radial direction C when fluid is supplied to the fluid storage space 30a. Furthermore, the expandable body 30 of this embodiment is contractable inward in the radial direction C when fluid is discharged from the fluid storage space 30a. The central portion of the balloon as the expandable body 30 of this embodiment in the central axis direction A is a peripheral wall portion 35a that is approximately cylindrical in the expanded state, and both ends of the balloon in the central axis direction A are tapered portions 35b that decrease in diameter toward both ends. As shown in FIG. 2 , the tapered portions 35b may be configured in a hemispherical shape. However, the shape of the tapered portion 35b is not limited to a hemispherical shape, and may be, for example, a conical shape.

[0042] As shown in Fig. 3, the expansion body 30 includes a second light-transmitting window 31 and a second light-shielding portion 32. The second light-transmitting window 31 is arranged in only a portion of the circumferential direction B at a position where it at least partially overlaps with the first light-transmitting window 11 in the central axial direction A. The second light-transmitting window 31 is configured to allow light from the light irradiation unit 200 housed in the housing space 10a to transmit outward in the radial direction C. The second light-shielding portion 32 is arranged adjacent to the second light-transmitting window 31 in the circumferential direction B. The transmittance of the second light-shielding portion 32 outward in the radial direction C of light from the light-irradiating portion 200 housed in the storage space 10a (hereinafter simply referred to as the "transmittance of the second light-shielding portion 32") is smaller than the transmittance of the second light-transmitting window portion 31 outward in the radial direction C of light from the light-irradiating portion 200 housed in the storage space 10a (hereinafter simply referred to as the "transmittance of the second light-transmitting window portion 31").

[0043] In this embodiment, the second light-transmitting window 31 and the second light-shielding section 32 of the expansion body 30 are realized by a layered relationship between a transparent layer 91a and a light-shielding layer 91b. Specifically, the expansion body 30 of this embodiment includes a transparent layer 91a located on the inside in the radial direction C and a light-shielding layer 91b located on the outside in the radial direction C. The transparent layer 91a is configured to transmit light from the light emitting unit 200 housed in the accommodation space 10a outward in the radial direction C. The light-shielding layer 91b is configured so that the transmittance of light from the light emitting unit 200 housed in the accommodation space 10a outward in the radial direction C is smaller than the transmittance of the transparent layer 91a. The second light-transmitting window 31 of the expansion body 30 of this embodiment does not have the light-shielding layer 91b layered on the transparent layer 91a, and is composed only of the transparent layer 91a. In contrast, the second light-shielding section 32 of the expansion body 30 of this embodiment is configured by layering the light-shielding layer 91b on the transparent layer 91a.

[0044] The expandable body 30 of this embodiment includes a base film portion 33 and a coating film portion 34 applied to the outer surface of the base film portion 33. The transmissive layer 91a of this embodiment is the base film portion 33. The light-shielding layer 91b of this embodiment is the coating film portion 34. The method for applying the coating film portion 34 to the base film portion 33 of this embodiment is not particularly limited. The coating film portion 34 may be applied to the base film portion 33 by, for example, dipping, spray coating, roll coating, screen printing, vacuum deposition, low-vacuum sputtering, or the like.

[0045] In addition, although the coating film portion 34 serving as the light-shielding layer 91b in this embodiment is laminated on the outer surface of the base film portion 33 serving as the light-transmitting layer 91a, this configuration is not limiting. The light-shielding layer 91b may also be laminated on the inner surface of the light-transmitting layer 91a.

[0046] The transparent layer 91 a may be made of, for example, a transparent resin. Examples of the transparent material that makes up the transparent layer 91 a include polyethylene terephthalate, polyurethane, polyamide, and a laminate of multiple materials selected from these materials.

[0047] The light-shielding layer 91b may be made of any material as long as it has a lower transmittance of light from the light irradiation unit 200 than the light-transmitting layer 91a. As with the light-shielding layer 90b described above, the light-shielding material that makes up the light-shielding layer 91b may be, for example, any of various metal materials such as titanium oxide, barium sulfate, zinc oxide, silver, and aluminum. The light-shielding layer 91b may also be made of a resin containing particles of the above-mentioned metal materials, carbon black, or the like.

[0048] In this way, of the light from the light irradiation unit 200 housed in the housing space 10a of the first tubular body 10, the light that passes through the first tubular body 10 is mainly emitted to the outside in the radial direction C of the expansion body 30 through the second light-transmitting window portion 31 provided in only a part of the circumferential direction B. In other words, by providing the second light-transmitting window portion 31 in only a part of the circumferential direction B, the expansion body 30 has optical directionality in which the light emitted from the inside of the expansion body 30 to the outside in the radial direction C is mainly limited to a part of the circumferential direction B.

[0049] As described above, in the light irradiation device 1, a light-transmitting window portion and a light-shielding portion are provided in both the first tubular body 10 and the expansion body 30. That is, in the light irradiation device 1, both the first light-shielding portion 12 of the first tubular body 10 and the second light-shielding portion 32 of the expansion body 30, which is located outside the first light-shielding portion 12 in the radial direction C, can prevent light from the light irradiation portion 200 from transmitting to the outside of the expansion body 30. Therefore, in order to obtain a predetermined light-shielding performance by the first tubular body 10 and the expansion body 30, the light-shielding performance of the second light-shielding portion 32 of the expansion body 30 may be lower than in a case where a light-shielding portion is provided only in the expansion body 30 without providing a light-shielding portion in the first tubular body 10, and therefore the thickness of the second light-shielding portion 32 can be made thinner. This makes it easier to achieve a thinner diameter when the expansion body 30 has the second light-transmitting window portion 31 and the second light-shielding portion 32 in a contracted state, even if the expansion body 30 has the second light-transmitting window portion 31 and the second light-shielding portion 32.

[0050] 3, the first light-transmitting window 11 of the first tubular body 10 and the second light-transmitting window 31 of the expandable body 30 are preferably arranged in positions where they at least partially overlap in the circumferential direction B. In other words, the first light-transmitting window 11 and the second light-transmitting window 31 preferably overlap at least partially in the circumferential direction B in the radial direction C. Hereinafter, for convenience of explanation, the overlapping region of the first light-transmitting window 11 and the second light-transmitting window 31 in the circumferential direction B will be simply referred to as the "overlapping region S."

[0051] By providing such an overlapping region S, the light emitted from the light emitting unit 200 housed in the housing space 10a is emitted mainly through the overlapping region S to the outside in the radial direction C of the expandable body 30, and is irradiated onto a lesion such as a tumor in the lumen. In other words, by providing the overlapping region S, a portion of the light emitted from the light emitting unit 200 to the outside in the radial direction C is emitted to the outside of the expandable body 30 through the overlapping region S without being attenuated by the first light-shielding portion 12 and the second light-shielding portion 32. Therefore, compared to a configuration in which the overlapping region S is not provided, the light energy of the light emitted to the outside in the radial direction C from the second light-transmitting window portion 31 of the expandable body 30 can be increased.

[0052] The range of the overlap region S is not particularly limited. However, as shown in FIG. 3 , the extension angle θ1 of the first light transmitting window 11 is preferably equal to or greater than the extension angle θ2 of the second light transmitting window 31. The "extension angle θ1" refers to the extension region of the first light transmitting window 11 in the circumferential direction B, expressed as a central angle about the central axis O of the first tubular body 10. The "extension angle θ2" refers to the extension region of the second light transmitting window 31 in the circumferential direction B, expressed as a central angle about the central axis O of the first tubular body 10. The first light transmitting window 11 is preferably positioned so as to overlap in the circumferential direction B with the entire region of the second light transmitting window 31 in the circumferential direction B (the region from the boundary between one second light transmitting window 31 and the second light-shielding portion 32 in the circumferential direction B, through the second light transmitting window 31, to the boundary between the other second light transmitting window 31 and the second light-shielding portion 32 in the circumferential direction B). In this way, the overlap region S becomes the entire area in the circumferential direction B of the second light-transmitting window portion 31. In other words, it is possible to suppress variation in the optical energy of the light that is emitted outward in the radial direction C from the second light-transmitting window portion 31 of the expandable body 30 and irradiated onto the lesion area depending on the position in the circumferential direction B of the second light-transmitting window portion 31.

[0053] As described above, the first light transmitting window 11 and the second light transmitting window 31 are arranged at positions where they at least partially overlap in the central axial direction A. As shown in Fig. 2 , in this embodiment, the entire extension region X2 of the second light transmitting window 31 in the central axial direction A is included in the extension region X1 of the first light transmitting window 11 in the central axial direction A. This makes it possible to suppress variation in the light energy of the light emitted outward in the radial direction C from the second light transmitting window 31 depending on the position of the second light transmitting window 31 in the central axial direction A.

[0054] Next, we will explain the transmittance, reflectance, and absorptance of the first light-transmitting window 11 and first light-shielding portion 12 of the first tubular body 10, and the second light-transmitting window 31 and second light-shielding portion 32 of the expansion body 30. The terms "transmittance," "reflectance," and "absorbance" used here refer to the transmittance, reflectance, and absorptance of light from the light irradiating portion 200 housed in the housing space 10a from the inside to the outside in the radial direction C. The sum of the transmittance, reflectance, and absorptance of each portion is 100%.

[0055] In the light irradiation device 1 of this embodiment, the transmittance of the second light-shielding portion 32 is lower than both the reflectance and the absorbance of the second light-shielding portion 32. The expandable body 30 is expanded in the lumen and placed by contacting the inner surface of the biological tissue that defines the lumen. In other words, light that passes through the expandable body 30 from the inside to the outside in the radial direction C is directly irradiated onto the biological tissue. Therefore, it is preferable that the expandable body 30 be configured to emit light outward in the radial direction C only from the second light-transmitting window portion 31. In other words, it is preferable that the second light-shielding portion 32 of the expandable body 30 be configured not to transmit light from the inside to the outside in the radial direction C. This can prevent light from being directly irradiated onto normal tissue other than the lesion. Therefore, it is preferable that the transmittance of the second light-shielding portion 32 be lower than both the reflectance and the absorbance of the second light-shielding portion 32.

[0056] Furthermore, from the viewpoint of further reducing the transmittance of the second light-shielding portion 32, it is preferable that the second light-shielding portion 32 includes, for example, a black layer. Specifically, in this embodiment, a black layer made of a resin containing carbon black is used as the light-shielding layer 91b. According to the second light-shielding portion 32 of this embodiment, by using a black layer as the light-shielding layer 91b, it is possible to further reduce the transmittance with a thin configuration. The transmittance, reflectance, and absorptance of the second light-shielding portion 32 of this embodiment satisfy the relationship of "transmittance < reflectance < absorptance."

[0057] As described above, it is preferable that the second light-shielding portion 32 of the expansion body 30 has a low transmittance of light from the light irradiation portion 200. More specifically, the transmittance of the second light-shielding portion 32 is preferably 10% or less, more preferably 5% or less, and particularly preferably 1% or less. By configuring the second light-shielding portion 32 to include a black layer as in this embodiment, it becomes easier to achieve such a low transmittance with a thin configuration.

[0058] Furthermore, the transmittance of the first light-shielding portion 12 is preferably smaller than the reflectance of the first light-shielding portion 12, and more preferably smaller than both the reflectance and absorptance of the first light-shielding portion 12. In this way, the light-shielding property of the first light-shielding portion 12 can be improved, and the light directivity of the first tubular body 10 through the first light-transmitting window portion 11 can be improved.

[0059] As described above, it is preferable that both the first light-shielding portion 12 and the second light-shielding portion 32 have a low transmittance. Here, when comparing the transmittance of the first light-shielding portion 12 for light from the light irradiation portion 200 with the transmittance of the second light-shielding portion 32 for light from the light irradiation portion 200, it is preferable that the transmittance of the second light-shielding portion 32 for light from the light irradiation portion 200 is lower than the transmittance of the first light-shielding portion 12 for light from the light irradiation portion 200. As described above, it is preferable that the transmittance of the second light-shielding portion 32 be as close to 0% as possible from the viewpoint of protecting normal tissue other than the lesion. In contrast, because the second light-shielding portion 32 is disposed outside the first light-shielding portion 12 in the radial direction C, the transmittance of the first light-shielding portion 12 does not need to be as low as the transmittance of the second light-shielding portion 32 from the viewpoint of protecting normal tissue other than the lesion.

[0060] Rather, it is preferable that the first light-shielding portion 12 has a high reflectance from the viewpoint of increasing the light energy of light emitted to the outside in the radial direction C through the first light-transmitting window portion 11. In other words, it is preferable that the reflectance of the first light-shielding portion 12 for the light from the light irradiation portion 200 is greater than each of the absorptance and transmittance of the first light-shielding portion 12 for the light from the light irradiation portion 200, and it is more preferable that the reflectance is greater than the sum of the absorptance and transmittance of the first light-shielding portion 12 for the light from the light irradiation portion 200.

[0061] As such, it is preferable that the first light-shielding portion 12 has a high reflectance. From this perspective, it is preferable that the first light-shielding portion 12 includes, for example, a white layer. Specifically, in this embodiment, a white layer made of a resin containing particles of a metal material such as titanium oxide, but not containing carbon black, is used as the light-shielding layer 90b. According to the first light-shielding portion 12 of this embodiment, by using a white layer as the light-shielding layer 90b, it is possible to increase the reflectance while maintaining a low transmittance. The transmittance, reflectance, and absorptance of the first light-shielding portion 12 of this embodiment satisfy the relationships of "transmittance < reflectance" and "absorbance < reflectance."

[0062] The reflectance of the first light-shielding portion 12 is, for example, 70% or more. The reflectance of the first light-shielding portion 12 is preferably 90% or more, more preferably 93% or more, and particularly preferably 95% or more. By configuring the first light-shielding portion 12 to include a white layer as in the present embodiment, it becomes easier to achieve the above-mentioned high reflectance while maintaining a relatively low transmittance.

[0063] Furthermore, when the reflectance of the first light-shielding part 12 to the light from the light-irradiating part 200 is compared with the reflectance of the second light-shielding part 32 to the light from the light-irradiating part 200, it is preferable that the reflectance of the first light-shielding part 12 to the light from the light-irradiating part 200 is greater than the reflectance of the second light-shielding part 32 to the light from the light-irradiating part 200. As described above, from the viewpoint of protecting normal tissue other than the lesion area, it is prioritized that the second light-shielding part 32 have a low transmittance. Therefore, the reflectance of the second light-shielding part 32 does not need to be as great as the reflectance of the first light-shielding part 12.

[0064] Next, other relationships between the transmittance, reflectance, and absorptance of the first light-transmitting window portion 11 and the first light-shielding portion 12 of the first tubular body 10, and the second light-transmitting window portion 31 and the second light-shielding portion 32 of the expansion body 30 will be explained.

[0065] The reflectance of the first light-shielding portion 12 is preferably greater than the reflectance of the first light-transmitting window portion 11. More specifically, the first light-transmitting window portion 11 is preferably configured to transmit light from the light-irradiating portion 200 without reflecting it. In contrast, as described above, the first light-shielding portion 12 is preferably configured to reflect light from the light-irradiating portion 200 toward the first light-transmitting window portion 11. In other words, from the perspective of reflectance, the reflectance of the first light-shielding portion 12 for light from the light-irradiating portion 200 is preferably greater than the reflectance of the first light-transmitting window portion 11 for light from the light-irradiating portion 200.

[0066] The transmittance of the first light-transmitting window 11 of the first tubular body 10 is preferably greater than the reflectance and absorptance of the first light-transmitting window 11 of the first tubular body 10. In addition, the transmittance of the first light-transmitting window 11 of the first tubular body 10 is preferably greater than the transmittance of the second light-shielding portion 32 of the expansion body 30.

[0067] The transmittance of the second light-transmitting window portion 31 of the expansion body 30 is preferably greater than the reflectance and absorptance of the second light-transmitting window portion 31 of the expansion body 30. In addition, the transmittance of the second light-transmitting window portion 31 of the expansion body 30 is preferably greater than the transmittance of the first light-shielding portion 12 of the first tubular body 10.

[0068] The reflectance of the first light-shielding portion 12 of the first tubular body 10 is preferably greater than the reflectance of the second light-transmitting window portion 31 of the expansion body 30 .

[0069] In this embodiment, the absorptance of the second light-shielding portion 32 of the expansion body 30 is greater than the absorptance of the second light-transmitting window portion 31 of the expansion body 30. Also, in this embodiment, the absorptance of the second light-shielding portion 32 of the expansion body 30 is greater than the absorptance of the first light-transmitting window portion 11 of the first tubular body 10. Furthermore, in this embodiment, the absorptance of the second light-shielding portion 32 of the expansion body 30 is greater than the absorptance of the first light-transmitting window portion 12 of the first tubular body 10. However, the magnitude relationship between the absorptances of the first light-transmitting window portion 11, the second light-transmitting window portion 31, the first light-shielding portion 12, and the second light-shielding portion 32 is not particularly limited.

[0070] Next, the overlapping relationship in the circumferential direction B between the first light-shielding portion 12 of the first tubular body 10 and the second light-shielding portion 32 of the expansion body 30 will be described. As shown in Fig. 3, the extension angle θ4 of the second light-shielding portion 32 is preferably equal to or greater than the extension angle θ3 of the first light-shielding portion 12. The "extension angle θ3" refers to the extension area of ​​the first light-shielding portion 12 in the circumferential direction B, which is expressed as a central angle around the central axis O of the first tubular body 10. Furthermore, the "extension angle θ4" refers to the extension area of ​​the second light-shielding portion 32 in the circumferential direction B, which is expressed as a central angle around the central axis O of the first tubular body 10. The second light-shielding portion 32 is preferably arranged at a position overlapping in the circumferential direction B with the entire area of ​​the first light-shielding portion 12 in the circumferential direction B (the area from the boundary between one first light-shielding portion 12 and the first light-transmitting window portion 11 in the circumferential direction B, through the first light-transmitting window portion 11, to the boundary between the other first light-shielding portion 12 and the first light-transmitting window portion 11 in the circumferential direction B). In other words, it is preferable that the entire area of ​​the first light-shielding portion 12 in the circumferential direction B overlaps with the second light-shielding portion 32 in the radial direction C. By doing so, even if some of the light emitted outward in the radial direction C from the light irradiation portion 200 passes through the first light-shielding portion 12, this transmitted light is likely to reach the second light-shielding portion 32 of the extension body 30. In other words, the transmitted light that passes through the first shading portion 12 is easily attenuated by the second shading portion 32 of the expansion body 30, and is prevented from passing outward in the radial direction C from the second light-transmitting window portion 31 of the expansion body 30.

[0071] 3 , in the light irradiation device 1 of this embodiment, the first light-shielding portion 12 extends in the circumferential direction B from a position adjacent to one end of the first light-transmitting window 11 to a position adjacent to the other end of the first light-transmitting window 11 without passing through the first light-transmitting window 11. In other words, in a cross-sectional view of the light irradiation device 1 perpendicular to the central axial direction A (see FIG. 3 ) at the position where the first light-transmitting window 11 is disposed in the central axial direction A, the first tubular body 10 includes only one first light-transmitting window 11 and one first light-shielding portion 12 in the circumferential direction B. That is, in this embodiment, the sum of the extension angle θ1 of the first light-transmitting window 11 and the extension angle θ3 of the first light-shielding portion 12 is 360 degrees.

[0072] As shown in FIG. 2, the first tubular body 10 has only one first light-transmitting window portion 11 in the central axis direction A.

[0073] As shown in Fig. 3 , in the light irradiation device 1 of this embodiment, the second light-shielding portion 32 extends in the circumferential direction B from a position adjacent to one end of the second light-transmitting window portion 31 to a position adjacent to the other end of the second light-transmitting window portion 31 without passing through the second light-transmitting window portion 31. In other words, in a cross-sectional view of the light irradiation device 1 perpendicular to the central axial direction A (see Fig. 3 ) at the position where the second light-transmitting window portion 31 is disposed in the central axial direction A, the expandable body 30 in the expanded state includes only one second light-transmitting window portion 31 and one second light-shielding portion 32 in the circumferential direction B. That is, in this embodiment, the sum of the extension angle θ2 of the second light-transmitting window portion 31 and the extension angle θ4 of the second light-shielding portion 32 is 360 degrees.

[0074] Also, as shown in Figure 2, the expansion body 30 has only one second light-transmitting window portion 31 at a position that at least partially overlaps with the first light-transmitting window portion 11 of the first tubular body 10 in the central axis direction A.

[0075] Furthermore, as shown in FIG. 2 , the expandable body 30 may include a viewing window 38 at a position that does not overlap with the first light-transmitting window 11 of the first tubular body 10 in the central axial direction A. The viewing window 38 is disposed at a distance from the first light-transmitting window 11 of the first tubular body 10 on the proximal side, which is the removal direction A2. Furthermore, the expandable body 30 of this embodiment includes a second light-shielding portion 32 not only at a position adjacent to the second light-transmitting window 31 in the circumferential direction B, but also at a position adjacent to the second light-transmitting window 31 on both sides of the central axial direction A in the insertion direction A1 and the removal direction A2. That is, the second light-shielding portion 32 of this embodiment is disposed surrounding the periphery of the second light-transmitting window 31. The viewing window 38 is not continuous with the second light-transmitting window 31, but is disposed at a distance from the second light-transmitting window 31 on the proximal side of the second light-transmitting window 31, with the second light-shielding portion 32 sandwiched therebetween. The viewing window 38 may be configured, for example, by a transparent layer 91 a, similar to the above-described second light-transmitting window 31. By providing such a viewing window 38, the second light-transmitting window 31 and the lesion with which the second light-transmitting window 31 comes into contact can be monitored by the endoscope device 101 through the viewing window 38.

[0076] More specifically, the first tubular body 10 of this embodiment includes a protruding portion 15 that protrudes distally from the distal end 20a1 of the second tubular body 20, which will be described later. The expandable body 30 of this embodiment also includes an expandable main body portion 35, a distal fixing portion 36, and a proximal fixing portion 37. The expandable main body portion 35 covers the outer periphery of the protruding portion 15 of the first tubular body 10 in the radial direction C. The expandable main body portion 35 is expandable and contractible in the radial direction C on the outer side of the protruding portion 15. The distal fixing portion 36 is connected to the distal side of the expandable main body portion 35. The distal fixing portion 36 is fixed to the outer surface of the protruding portion 15 of the first tubular body 10 by adhesive or the like. The proximal fixing portion 37 is connected to the proximal side of the expandable main body portion 35. The proximal fixing portion 37 is fixed to the outer surface of the second tubular body 20, which will be described later, by adhesive or the like. The second light-transmitting window 31 and viewing window 38 of the expandable body 30 described above are provided in the expandable main body 35. More specifically, the second light-transmitting window 31 of the expandable body 30 is provided in the peripheral wall 35a of the expandable main body 35, which is substantially cylindrical in the expanded state. In contrast, the viewing window 38 of the expandable body 30 is provided in the tapered portion 35b of the expandable main body 35, which is connected to the proximal side of the peripheral wall 35a and has a tapered shape that decreases in diameter in the removal direction A2 in the expanded state. By arranging the second light-transmitting window 31 and the viewing window 38 of the expandable body 30 in this manner, it becomes easier to monitor the second light-transmitting window 31 and the lesion that comes into contact with the second light-transmitting window 31 through the viewing window 38 using the endoscopic device 101.

[0077] The viewing window portion 38 may be a window portion that is continuous endlessly over the entire area in the circumferential direction B, or may be a window portion that is provided only in a part of the circumferential direction B.

[0078] Furthermore, the viewing window portion 38 in this embodiment is composed of a transparent layer 91a, similar to the second light-transmitting window portion 31, but may have a different configuration as long as it is configured to be visible through the endoscope device 101.

[0079] As shown in FIG. 2 , the second tubular body 20 covers the circumference of the first tubular body 10 in the radial direction C. More specifically, as described above, the first tubular body 10 of this embodiment includes the protrusion 15 that protrudes further distally from the distal end 20a1 of the second tubular body 20. The first tubular body 10 of this embodiment also includes the protrusion 16 that protrudes further proximally from the proximal end 20b1 of the second tubular body 20. The first tubular body 10 and the second tubular body 20 are concentrically arranged. Although the first tubular body 10 and the second tubular body 20 of this embodiment are fixed to the hub 40 so as to be concentric, this configuration is not limiting. For example, the first tubular body 10 and the second tubular body 20 may be directly connected to each other by a connecting portion that connects the outer surface of the first tubular body 10 and the inner surface of the second tubular body 20 in a concentric positional relationship.

[0080] The expandable body 30 of this embodiment spans the outer surface of the first tubular body 10 and the outer surface of the second tubular body 20 and is fixed to the outer surface of the first tubular body 10 and the outer surface of the second tubular body 20. More specifically, as described above, the expandable body 30 of this embodiment includes an expandable main body portion 35, a distal fixing portion 36, and a proximal fixing portion 37. The distal fixing portion 36 is fixed to the outer surface of the distal end portion 15a of the protrusion 15 of the first tubular body 10 by adhesive or the like. The proximal fixing portion 37 is fixed to the outer surface of the distal end portion 20a of the second tubular body 20 by adhesive or the like.

[0081] In this embodiment, the expandable body 30 is fixed to the first tubular body 10 and the second tubular body 20 so as to be concentric with the first tubular body 10 and the second tubular body 20 in the expanded state. However, the expandable body 30 does not have to be concentric with the first tubular body 10 and the second tubular body 20 in the expanded state. In other words, the expandable body 30 may be fixed to the first tubular body 10 and the second tubular body 20 so as to be eccentric and not coincident with the central axis of the first tubular body 10 and the second tubular body 20 in the expanded state. This allows the viewing angle of the second light-transmitting window portion 31 through the viewing window portion 38 from the endoscopic device 101 to be changed, making monitoring easier. Furthermore, when the central axis of the endoscopic device 101 does not coincide with the central axis of the first tubular body 10 and the second tubular body 20 to which the expandable body 30 is fixed, the central axis of the expandable body 30 in the expanded state can be brought closer to the central axis of the endoscopic device 101. This prevents the outer surface of the endoscopic device 101 from coming into contact with the inner surface of a biological lumen or the like more easily than the expansion body 30, even when the outer diameter of the expansion body 30 is not sufficiently larger than that of the endoscopic device 101, and makes it easier for the expansion body 30 to come into contact with the inner surface of a biological lumen or the like and to be positioned at the center of the lumen.

[0082] A fluid flow path 21 is defined between the first tubular body 10 and the second tubular body 20. The fluid is supplied to a fluid storage space 30a defined between the expandable body 30 and the outer surface of the first tubular body 10. The fluid supplied to the fluid storage space 30a may be a liquid, such as saline, or a gas, such as air. The flow path 21 has a distal opening 21a at the distal end 20a1 of the second tubular body 20, and communicates with the fluid storage space 30a through this distal opening 21a. The flow path 21 also has a proximal opening 21b that communicates with an internal hub flow path 40b defined by the hub 40 (described below). In other words, fluid is supplied to the fluid storage space 30a through the flow path 21 from the internal hub flow path 40b of the hub 40. Conversely, fluid is discharged from the fluid storage space 30a through the flow path 21 through the internal hub flow path 40b of the hub 40.

[0083] The material for forming the second tubular body 20 is not particularly limited, and may be, for example, a resin material. Examples of resin materials for forming the second tubular body 20 include the materials listed above as examples of the permeable layer 90a of the first tubular body 10. The second tubular body 20 may also be a metal such as stainless steel, iron, a nickel-titanium alloy, or aluminum. The second tubular body 20 may also be a braided tube reinforced by embedding a metal braided wire in a resin tube, a catheter reinforced by embedding a metal coil, a hypotube, or the like.

[0084] The light irradiation device 1 of this embodiment has a double-tube structure including a first tubular body 10 and a second tubular body 20 arranged concentrically, but is not limited to this configuration. The light irradiation device 1 may have a configuration including the first tubular body 10 but not the second tubular body 20. In such a case, the first tubular body 10 may have, in addition to the storage space 10a, another lumen capable of supplying fluid to the expandable body 30. Furthermore, the cross-sectional outer shape of the expandable body 30 in the expanded state, which is perpendicular to the central axial direction A, is not limited to the circle of this embodiment, and may be, for example, an ellipse, a polygon such as a hexagon or octagon, or the like.

[0085] 2 , the light irradiation device 1 may include a hub 40. The hub 40 of this embodiment is attached to the proximal end 20b of the second tubular body 20. The hub 40 of this embodiment also holds the protruding portion 16 of the first tubular body 10, which protrudes proximally from the second tubular body 20, so that the first tubular body 10 and the second tubular body 20 are concentric. Furthermore, the hub 40 holds the protruding portion 16 of the first tubular body 10 so that the light irradiator 201 can be inserted into the proximal opening 10a1 of the accommodation space 10a of the first tubular body 10.

[0086] As shown in Figure 2, the hub 40 includes a hub body 41 and a connecting portion 42 that is threadedly engaged with the hub body 41. The hub body 41 includes a port portion 40a to which a fluid supply device 105 (see Figure 1) such as a syringe can be connected. By connecting the fluid supply device 105 to the port portion 40a, fluid can be supplied to the fluid storage space 30a of the expandable body 30 through the hub internal flow path 40b and the flow path 21.

[0087] The connecting portion 42 holds the light irradiator 201 so as to surround it. The connecting portion 42 is connected to the hub body 41 by screwing when the light irradiator 201 is inserted into the accommodation space 10a of the first tubular body 10. This fixes the relative positions of the light irradiator 201 and the light irradiation device 1 in the central axis direction A. Conversely, by releasing the screwing between the hub body 41 and the connecting portion 42, the light irradiator 201 can be removed from the first tubular body 10 of the light irradiation device 1.

[0088] 2 , the light irradiation device 1 may include an operation unit 50. The operation unit 50 may be fixed on the outer surface of the second tubular body 20. An operator of the light irradiation device 1 can move the light irradiation device 1 in the central axis direction A and rotate the light irradiation device 1 in the circumferential direction B by holding and operating the operation unit 50.

[0089] As shown in Fig. 2 , the light irradiation device 1 may include a fixing portion 60. As shown in Fig. 1 , the fixing portion 60 is used to fix the light irradiation device 1 to an endoscope apparatus 101 (see Fig. 1 ). More specifically, the light irradiation device 1 of this embodiment can be attached to the endoscope apparatus 101 by fixing the fixing portion 60 to the endoscope apparatus 101 with the portion of the light irradiation device 1 distal to the fixing portion 60 inserted into a treatment tool channel of the endoscope apparatus 101.

[0090] As shown in FIG. 2 , the light irradiation device 1 may include a marker portion 70. The marker portion 70 may be made of, for example, a metal with high radiopacity, such as platinum, gold, iridium, or tungsten, which has radiopaque properties. The marker portion 70 is arranged, for example, at a position overlapping the first light-transmitting window portion 11 and the second light-transmitting window portion 31 in the circumferential direction B. By providing such a marker portion 70, the position of the second light-transmitting window portion 31 of the light irradiation device 1 in the circumferential direction B can be confirmed through an X-ray image. The arrangement position of the marker portion 70 in the central axis direction A is not particularly limited. The marker portion 70 may be attached, for example, to the outer surface of the first tubular body 10. As shown in FIG. 2 , the marker portion 70 may be attached, for example, to a position on the outer surface of the first tubular body 10 that overlaps the proximal fixing portion 37 of the expandable body 30 in the central axis direction A.

[0091] As shown in Fig. 2, the light irradiation device 1 may include a distal protection part 80. The distal protection part 80 constitutes the distal end of the light irradiation device 1. The distal protection part 80 may be made of, for example, an elastic material. As shown in Fig. 2, the distal protection part 80 may be fixed to the distal end of the first tubular body 10. By providing such a distal protection part 80, it is possible to prevent the distal end of the light irradiation device 1 from damaging biological tissue surrounding the lumen.

[0092] The light irradiation device according to the present disclosure is not limited to the specific configuration shown in the above-described embodiment, and various modifications, changes, and combinations are possible without departing from the scope of the claims. The light irradiation device 1 of the above-described embodiment includes a first tubular body 10, a second tubular body 20, an expansion body 30, a hub 40, an operation unit 50, a fixing unit 60, a marker unit 70, and a distal protection unit 80, but is not limited to this configuration. For example, the light irradiation device 1 may be configured without the second tubular body 20, the hub 40, the operation unit 50, the fixing unit 60, the marker unit 70, and the distal protection unit 80.

[0093] The present disclosure relates to light illumination devices.

[0094] 1: Light irradiation device 10: First tubular body 10a: Storage space 10a1: Proximal opening of storage space 11: First light-transmitting window portion 12: First light-shielding portion 13: Tube main body portion 14: Coating film portion 15: Distal protrusion portion 15a: Distal end portion of protrusion portion 15b: Closure wall 16: Proximal protrusion portion 20: Second tubular body 20a: Distal end portion 20a1: Distal end portion 20b: Proximal end portion 20b1: Proximal end portion 21: Flow path 21a: Distal opening 21b: Proximal opening 30: Expansion body (an example of an outer cylindrical body) 30a: Fluid storage space 31: Second light-transmitting window portion 32: Second light-shielding portion 33: Base film portion 34: Coating film portion 35: Expansion main body portion 35a: Circumferential wall portion 35b: Tapered portion 36: Distal side fixing portion 37: Proximal side fixing portion 38: Viewing window portion 40: Hub 40a: Port portion 40b: Hub internal flow path 41: Hub body 42: Connection portion 50: Operation portion 60: Fixing portion 70: Marker portion 80: Distal protection portion 90a: Transparent layer of first tubular body 90b: Light-blocking layer of first tubular body 91a: Transparent layer of expandable body 91b: Light-blocking layer of expandable body 100: Endoscope system 101: Endoscope device 102: Control device 102a: Light source portion 102b: Processor portion 103: Display portion 104: Light source device 105: Fluid supply tool 200: Light irradiating portion 201: Light irradiating body 202: Optical transmission member A: Central axis direction A1: Insertion direction A2: Removal direction B: Circumferential direction C: Radial direction O: central axis of the first tubular body S: overlapping region X1: extension region of the first light transmitting window portion in the central axis direction X2: extension region of the second light transmitting window portion in the central axis direction θ1 to θ4: extension angles

Claims

1. A long tubular body that defines an accommodation space inside which a light irradiation unit is accommodated or can be accommodated; and an outer cylindrical body that covers the radial outside of the tubular body and is capable of expanding and contracting in the radial direction, wherein the tubular body comprises: a first light transmitting window portion that is arranged only on a portion of the circumferential direction of the tubular body and that allows light from the light irradiation unit accommodated in the accommodation space to transmit outward in the radial direction; and a first light blocking portion that is adjacent to the first light transmitting window portion in the circumferential direction and has a transmittance to the outside in the radial direction of light from the light irradiation unit accommodated in the accommodation space that is smaller than the transmittance of the first light transmitting window portion; and the outer cylindrical body comprises: a second light transmitting window portion that is arranged only on a portion of the circumferential direction at a position that at least partially overlaps with the first light transmitting window portion in the central axial direction of the tubular body and that allows light from the light irradiation unit accommodated in the accommodation space to transmit outward in the radial direction; a second light-shielding portion that is adjacent to the second light-transmitting window portion in the circumferential direction and has a transmittance to the outside in the radial direction of light from the light-emitting portion accommodated in the accommodation space that is smaller than the transmittance of the second light-transmitting window portion.

2. The light irradiation device according to claim 1, wherein the first light-transmitting window portion and the second light-transmitting window portion are arranged at positions where they at least partially overlap each other in the circumferential direction.

3. A light irradiation device as described in claim 2, wherein an extension angle of the first light-transmitting window portion, expressed as a central angle about the central axis of the tubular body, is equal to or greater than an extension angle of the second light-transmitting window portion, expressed as a central angle about the central axis of the tubular body, and the first light-transmitting window portion is disposed at a position overlapping in the circumferential direction with the entire circumferential area of ​​the second light-transmitting window portion.

4. A light irradiation device described in any one of claims 1 to 3, wherein an extension angle of the second light-shielding portion, represented by a central angle about the central axis of the tubular body, is equal to or greater than an extension angle of the first light-shielding portion, represented by a central angle about the central axis of the tubular body, and the second light-shielding portion is disposed at a position overlapping in the circumferential direction with the entire circumferential area of ​​the first light-shielding portion.

5. A light irradiation device according to any one of claims 1 to 3, wherein the transmittance of the second light shielding portion for the light from the light irradiation portion is smaller than each of the reflectance and absorptance of the second light shielding portion for the light from the light irradiation portion.

6. The light irradiation device according to claim 5, wherein the reflectance of said first light shielding portion for the light from said light irradiation portion is greater than each of the transmittance and absorptance of said first light shielding portion for the light from said light irradiation portion.

7. The light irradiation device according to claim 6, wherein the transmittance of said second light shielding portion for the light from said light irradiation portion is smaller than the transmittance of said first light shielding portion for the light from said light irradiation portion.

8. The light irradiation device according to claim 7, wherein the reflectance of the first light shielding portion for the light from the light irradiation portion is greater than the reflectance of the second light shielding portion for the light from the light irradiation portion.

9. A light-illuminating device according to any one of claims 1 to 3, wherein the first light-shielding portion extends in the circumferential direction from a position adjacent to one end of the first light-transmitting window portion to a position adjacent to the other end of the first light-transmitting window portion.

10. A light-illuminating device according to any one of claims 1 to 3, wherein the second light-shielding portion extends in the circumferential direction from a position adjacent to one end of the second light-transmitting window portion to a position adjacent to the other end of the second light-transmitting window portion.

11. The light irradiation device according to any one of claims 1 to 3, wherein the outer cylindrical body is an expandable body that is changeable from a contracted state to an expanded state.

12. A light irradiation device as described in any one of claims 1 to 3, comprising a second tubular body covering the radial circumference of the first tubular body when the tubular body is a first tubular body, and the outer cylindrical body is fixed to the outer surface of the first tubular body and the outer surface of the second tubular body, spanning both the outer surface of the first tubular body and the outer surface of the second tubular body.

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