Intraocular oct optical fiber probe

Abstract

The present invention relates to an OCT and ophthalmic operation device integration system. The system comprises an OCT probe, a display, an OCT module, a light source module, and a power supply module, wherein the OCT module is used for receiving a detection signal of the OCT probe and converting same into an image. The OCT probe comprises an optical fiber head end and an optical fiber handle. The optical fiber head end comprises an OCT optical fiber, an optical fiber metal sleeve, and a light guide optical fiber; and the optical fiber handle comprises a rotating motor and a handle housing. The head end of the OCT optical fiber and the head end of the light guide optical fiber are fixedly packaged in the optical fiber metal sleeve; the optical fiber metal sleeve is further connected to the rotating motor, and the optical fiber metal sleeve is driven by the rotating motor to rotate; the rotating motor is electrically connected to a power line, and the power line is further electrically connected to the power supply module; at least one part of the optical fiber metal sleeve and the rotating motor are both arranged in the handle housing; the tail end of the light guide optical fiber penetrates out of the end part of the handle housing and is connected to the light source module; and the tail end of the OCT optical fiber penetrates out of the end part of the handle housing and is connected to the OCT module.

Description

An intraocular OCT fiber optic probe

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to Chinese patent application CN202211395260.4, filed on November 9, 2022, entitled “A kind of intraocular OCT fiber optic probe”, and Chinese patent application CN2023114541806, filed on November 3, 2023, entitled “A kind of fiber optic scanning detection system and method for ophthalmology”, and the entire contents of the above applications are incorporated herein by reference. Technical Field

[0003] The present invention relates to the technical field of medical devices, and in particular to an intraocular OCT fiber optic probe, and a fiber optic scanning detection system and method for ophthalmology. Background Art

[0004] Optical coherence tomography (OCT) is a medical imaging technique based on low-coherence interferometry. OCT imaging systems are currently widely used in ophthalmology and cardiology. In ophthalmology, these systems are currently used as outpatient examination equipment for preoperative and postoperative imaging of ocular structures such as the retina.

[0005] OCT works by utilizing the varying reflectivity of different tissues within the eye to light (830nm near-infrared light). Using a low-coherence optical interferometer, the delay time and reflection intensity of the reflected light wave are compared with a reference light wave to analyze the structure of the different tissues and their distances. Computer processing then generates images and displays the cross-sectional structure of the tissue in pseudo-color. Therefore, OCT requires an oscillating mirror, leading to the current state of OCT being mostly desktop-based.

[0006] Traditional ophthalmic OCT is a desktop device typically used within the examination room for preoperative quantification of intraocular pathology and postoperative follow-up. Current surgical applications integrate OCT within a microscope, facilitating intraoperative retinal scanning and assessment of intraocular lesion treatment. However, this non-invasive approach can be affected by the refractive media, compromising image quality.

[0007] Currently, invasive OCT is primarily used in cardiology and coronary stent adhesion testing. Due to the limited operating space, difficult lighting, and poor control of scanning direction, invasive ophthalmology examinations have not yet found a good solution.

[0008] Traditional OCT systems have been widely used in the field of ophthalmic examinations and are mainly used for ophthalmic-related tests or inspections. Traditional OCT systems require a swinging mirror, so the OCT sample arm is mostly a lens-type scanning structure. This structure will be affected by the refractive media in measurement, as well as the measurement angle range, which will affect the image quality. In addition, the existing OCT can only change the scanning range by swinging the mirror during the scanning process. In other words, it relies solely on the swing range of the galvanometer. In fact, in some cases, it is impossible to scan or detect the range or area you want to detect. In addition, there is still a lot of room for improvement in many aspects, such as how to optimize the scanning and detection system, further realize that the measurement angle range is not affected by the equipment, and avoid the detection process being affected by the refractive media.

[0009] Therefore, it is necessary to provide an optical fiber scanning detection system and method for ophthalmology that can solve the above problems.

[0010] Summary of the Invention

[0011] On one hand, the present invention provides an intraocular OCT fiber optic probe. The technical problems to be solved include at least how to apply invasive OCT examinations to ophthalmology, ensuring that intraoperative OCT scanning is unaffected by the refractive media, facilitating illumination, enabling manually controllable scanning direction, and achieving more accurate and convenient positioning. Furthermore, the present invention provides a fiber optic scanning and detection system and method for ophthalmology to address technical issues in the prior art, such as the inability to detect certain desired areas or regions due to the limited oscillation range of the galvanometer mirror, and the poor detection accuracy caused by the influence of the refractive media during the detection process. The technical problems to be solved by the present invention are achieved through the following technical solutions.

[0012] To achieve the above-mentioned objectives, the present invention provides, in a first aspect, an intraocular OCT fiber optic probe, comprising an OCT optical fiber, an optical fiber metal sleeve, an optical fiber, a rotary motor, and a handle housing, wherein the head ends of the OCT optical fiber and the optical fiber are fixedly encapsulated inside the optical fiber metal sleeve; the optical fiber metal sleeve is also connected to the rotary motor, which drives the optical fiber metal sleeve to rotate and drives the head ends of the OCT optical fiber and the optical fiber to rotate through the optical fiber metal sleeve; the rotary motor is electrically connected to a power cord, which provides power to the rotary motor; at least a portion of the optical fiber metal sleeve and the rotary motor are both disposed within the handle housing; the tail end of the optical fiber extends through the end of the handle housing and is connected to an illumination light source, and the optical fiber is used to provide illumination; the tail end of the OCT optical fiber extends through the end of the handle housing and is connected to an OCT examination device, and the OCT optical fiber is used to perform invasive intraocular OCT examinations.

[0013] According to an optional embodiment, the gaps between the head ends of the OCT optical fiber and the optical fiber and the inner wall of the optical fiber metal sleeve are filled with AB glue.

[0014] According to an optional embodiment, the rotary motor drives the optical fiber metal sleeve to rotate instead of rotating the optical fiber.

[0015] According to an optional embodiment, the optical fiber is a multimode optical fiber.

[0016] According to an optional embodiment, the optical fiber is a single-mode optical fiber.

[0017] According to an optional embodiment, the rotation of the optical fiber metal sleeve enables the scanning rotation angle of the intraocular OCT optical fiber to be 1° to 360°.

[0018] According to an optional embodiment, the OCT optical fiber includes a single-mode optical fiber, a spring tube, a glass rod, a self-focusing lens and a reflector, and the single-mode optical fiber is sheathed in the spring tube; one end of the glass rod is glued to the zero-degree angle surface of the self-focusing lens, and the other end of the glass rod is glued to the single-mode optical fiber at an angle, and the working distance of the OCT probe can be changed by changing the gluing distance between the glass rod and the single-mode optical fiber to achieve the expected working distance, thereby improving the numerical aperture and lateral resolution of the OCT probe; the single-mode optical fiber, spring tube, glass rod, self-focusing lens and reflector are encapsulated in the optical fiber metal sleeve, and the reflector is used to reduce the influence of the astigmatism of the light source passing through the cylindrical inner tube of the optical fiber metal sleeve on imaging.

[0019] According to an optional embodiment, the optical fiber metal sleeve is a slotted stainless steel tube, and a groove is provided on the side wall of the optical fiber metal sleeve. The reflecting surface of the reflector faces the slotted opening of the groove, which is used to reduce the influence of the astigmatism of the light source passing through the cylindrical inner tube of the optical fiber metal sleeve on the imaging.

[0020] According to an optional embodiment, the reflector is a cylindrical reflector.

[0021] According to an optional embodiment, the end of the optical fiber metal sleeve is sealed with UV glue.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] The OCT fiber optic probe of the present invention uses OCT for intraocular examination and can be integrated with an optical fiber. OCT examination can be performed while using conventional lighting, and intraoperative OCT scanning is not affected by the refractive medium.

[0024] The intraocular OCT optical fiber described in the present invention changes the working distance of the OCT probe to achieve the desired working distance by changing the bonding distance between the glass rod 3 and the single-mode optical fiber 1, thereby improving the numerical aperture and lateral resolution of the OCT probe. By making the reflective surface of the reflector 5 face the slotted opening of the slotted stainless steel tube 6, the effect of astigmatism of the light source passing through the cylindrical inner tube on imaging can be reduced.

[0025] The second aspect of the present invention proposes an optical fiber scanning detection system for ophthalmology, comprising: a detection device for automatically detecting an object to be combined and its positioning point; an OCT scanning optical fiber assembly, one end of which is connected to a lens structure; the OCT scanning optical fiber assembly is used to scan the position of the object to be combined and the position of the positioning point; a manipulator, which is used to grab and carry the OCT scanning optical fiber assembly to scan the object to be combined, and further place the OCT scanning optical fiber assembly on the positioning point or designated point of the object to be combined; a controller, which is electrically connected to the detection device and the manipulator, the controller is used to control the detection device to automatically detect the object to be combined and its positioning point, the controller is used to control the manipulator to place the OCT scanning optical fiber assembly on the positioning point or designated point of the object to be combined; and the OCT scanning optical fiber assembly and the object to be combined form an implant detection structure

[0026] According to an optional embodiment, the lens structure includes a first lens, the optical axis direction of the first lens forms a specified angle with the cross section of the OCT scanning optical fiber assembly, and the specified angle ranges from 0 degrees to 90 degrees.

[0027] According to an optional embodiment, one end of the OCT scanning fiber assembly is connected to the first lens so that the angle formed between the optical axis direction of the first lens and the cross section of the OCT scanning fiber assembly is 20 degrees to 90 degrees.

[0028] According to an optional embodiment, the OCT scanning fiber assembly includes a detection matching part; the controller controls the manipulator to place the detection matching part on a positioning point or a designated point of the object to be matched according to the area to be detected of the object to be matched.

[0029] According to an optional embodiment, it includes: the detection matching part of the OCT scanning optical fiber assembly and the positioning point or designated point of the object to be matched form an implanted detection structure, and the implanted detection structure includes a detection angle formed by the detection matching part and the area to be detected of the object to be matched.

[0030] According to an optional embodiment, the controller is further configured to determine a movement direction of the detection mating portion of the OCT scanning optical fiber assembly based on the automatically detected object to be mated and its positioning point, as well as the area to be detected of the object to be mated.

[0031] According to an optional embodiment, the controller is used to control the OCT scanning fiber optic assembly to move linearly along the determined direction to adjust the detection angle formed by the detection matching part and the area to be detected of the object to be matched within a set range; or the controller is used to control the OCT scanning fiber optic assembly to move linearly along the determined direction, and then move in a circular motion relative to the center of the object to be matched, so as to adjust the detection angle formed by the detection matching part and the area to be detected of the object to be matched within a set range.

[0032] According to an optional embodiment, the object to be combined is a sphere; the fiber optic scanning system further includes an illumination fiber, which is used to transmit a visible light source to illuminate the area to be detected of the object to be combined.

[0033] The third aspect of the present invention provides a fiber optic scanning imaging method for ophthalmology, which is used to execute the fiber optic scanning detection system described in the first aspect of the present invention. The fiber optic scanning imaging method includes: using a detection device to automatically detect the object to be combined and its positioning point; determining the movement direction of the detection matching part of the OCT scanning fiber optic assembly relative to the area to be detected based on the area to be detected and the determined positioning point, and the movement direction includes the linear direction and / or circumferential direction determined by the positioning point, the first edge point and the second edge point of the area to be detected; controlling the manipulator by a controller to grab and carry the OCT scanning fiber optic assembly to move along the determined linear direction and / or circumferential direction, and scanning and detecting the object to be combined to obtain a detection image of the area to be detected of the object to be combined.

[0034] The embodiments of the present invention include the following advantages:

[0035] Compared with the prior art, the present invention automatically detects the object to be combined and its positioning point through detection equipment; controls the robot arm to grab and carry the OCT scanning fiber assembly to scan the object to be combined through a controller, and further places the OCT scanning fiber on the positioning point or designated point of the object to be combined to form an implanted detection structure with the object to be combined, so as to scan and detect the area to be detected of the object to be combined, thereby improving the detection accuracy of the area to be detected and increasing the scanning detection range. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] The accompanying drawings are used to provide a further understanding of the technical solution of the present invention and constitute a part of the specification. Together with the specific embodiments of the present application, they are used to explain the technical solution of the present invention and do not constitute a limitation on the technical solution of the present invention.

[0037] FIG1 is a schematic diagram of the internal structure of the intraocular OCT optical fiber according to the present invention.

[0038] FIG2 is a schematic diagram of the overall structure of the intraocular OCT optical fiber according to the present invention.

[0039] FIG3 is a schematic structural diagram of an embodiment of the intraocular OCT optical fiber.

[0040] FIG4 is a schematic structural diagram of another embodiment of the intraocular OCT optical fiber.

[0041] FIG5 is a schematic diagram of an example of an optical fiber scanning detection system for ophthalmology according to the present invention;

[0042] FIG6 is a schematic diagram of an application scenario of the optical fiber scanning detection system for ophthalmology according to the present invention;

[0043] 7 is a schematic structural diagram of an application example of the optical fiber scanning detection system for ophthalmology of the present invention;

[0044] FIG8 is a schematic diagram of a partial structure of an OCT scanning optical fiber and a scanning needle of an OCT scanning optical fiber assembly in the optical fiber scanning detection system for ophthalmology of the present invention;

[0045] FIG9 is an enlarged schematic diagram of a partial structure of one end portion of an OCT scanning optical fiber assembly in an optical fiber scanning detection system for ophthalmology according to the present invention;

[0046] FIG10 is a schematic structural diagram of a specific embodiment of FIG7;

[0047] FIG11 is a schematic structural diagram of another specific embodiment of FIG7;

[0048] FIG12 is a flow chart showing an example of the fiber optic scanning imaging method for ophthalmology according to the present invention. DETAILED DESCRIPTION

[0049] The present invention is described in more detail below to facilitate understanding of the present invention.

[0050] As shown in Figures 1 and 2, the intraocular OCT optical fiber of the present invention includes an OCT optical fiber 30, an optical fiber metal sleeve 6, an optical fiber 8, a rotary motor 9, and a handle housing 10. The head ends of the OCT optical fiber 30 and the optical fiber 8 are fixedly enclosed within the optical fiber metal sleeve 6. The optical fiber metal sleeve 6 is also connected to the rotary motor 9, which drives the optical fiber metal sleeve 6 to rotate, and the head ends of the OCT optical fiber 30 and the optical fiber 8 to rotate through the optical fiber metal sleeve 6. The rotary motor 9 is electrically connected to a power cord 11, which provides power to the rotary motor 9. At least a portion of the optical fiber metal sleeve 6 and the rotary motor 9 are both disposed within the handle housing 10. The tail end of the optical fiber 8 extends through the end of the handle housing 10 and is connected to an illumination light source. The optical fiber 8 is used to provide illumination. The tail end of the OCT optical fiber 30 extends through the end of the handle housing 10 and is connected to an OCT examination device. The OCT optical fiber 30 is used to perform invasive intraocular OCT examinations.

[0051] Preferably, the gaps between the head ends of the OCT optical fiber 30 and the optical fiber 8 and the inner wall of the optical fiber metal sleeve 6 are filled with AB glue.

[0052] In this application, the rotary motor 9 drives the optical fiber metal sleeve 6 to rotate, rather than rotating the optical fiber. This arrangement has the advantage that rotating the optical fiber metal sleeve stabilizes the entire intraocular OCT optical fiber, thereby ensuring more accurate OCT examinations. Directly rotating the optical fiber, on the other hand, can cause significant fiber shaking, affecting the accuracy of OCT examinations.

[0053] In a preferred embodiment, the optical fiber 8 is a multimode optical fiber.

[0054] In another preferred embodiment, the optical fiber 8 is a single-mode optical fiber.

[0055] Preferably, the rotation of the optical fiber metal sleeve 6 enables the scanning rotation angle of the intraocular OCT optical fiber to be 1° to 360°.

[0056] The schematic diagram shown in FIG2 is for illustrative purposes only. Those skilled in the art will fully understand that the head end and tail end of the OCT optical fiber 30 are connected together as an integral optical fiber, and the head end and tail end of the optical fiber 8 are also connected together as an integral optical fiber. Those skilled in the art who are familiar with common technical knowledge in this field will understand that the OCT optical fiber 30 and the optical fiber 8 do not need to be connected to the rotary motor 9. A clearance groove can be provided on the housing of the rotary motor 9 to allow the OCT optical fiber 30 and the optical fiber 8 to pass through, and there is no need to overcome technical obstacles.

[0057] Preferably, the OCT optical fiber 30 includes a single-mode optical fiber 1, a spring tube 2, a glass rod 3, a self-focusing lens 4 and a reflector 5, and the single-mode optical fiber 1 is sleeved in the spring tube 2; one end of the glass rod 3 is glued to the zero-degree angle surface of the self-focusing lens 4, and the other end of the glass rod 3 is glued to the single-mode optical fiber 1 at an angle. The working distance of the OCT probe can be changed by changing the gluing distance between the glass rod 3 and the single-mode optical fiber 1 to achieve the expected working distance, thereby improving the numerical aperture and lateral resolution of the OCT probe; the single-mode optical fiber 1, spring tube 2, glass rod 3, self-focusing lens 4 and reflector 5 are encapsulated in the optical fiber metal sleeve 6, and the reflector 5 is used to reduce the influence of the astigmatism of the light source passing through the cylindrical inner tube of the optical fiber metal sleeve 6 on imaging.

[0058] Preferably, the optical fiber metal sleeve 6 is a slotted stainless steel tube, and a groove 40 is provided on the side wall of the optical fiber metal sleeve 6. The reflecting surface of the reflector 5 faces the slotted opening of the groove 40, which is used to reduce the influence of the astigmatism of the light source passing through the cylindrical inner tube of the optical fiber metal sleeve 6 on the imaging.

[0059] Preferably, the reflector 5 is a cylindrical reflector, and at least one reflective surface of the reflector forms an angle with the optical fiber that is not 90°.

[0060] Preferably, the end of the optical fiber metal sleeve 6 is sealed with UV glue 20.

[0061] The spring tube 2 is used to protect the single-mode optical fiber 1 .

[0062] The intraocular OCT fiber described in the present invention can be used in ophthalmology. During intraoperative OCT scanning, it is not affected by the refractive medium, the scanning direction is manually controllable, positioning is more accurate and more convenient, and whether the surgical goal has been achieved can be confirmed during the operation without the need for postoperative confirmation.

[0063] The rotary motor in the present invention drives the optical fiber metal sleeve 6 to rotate instead of rotating the optical fiber, and the scanning rotation angle is 1° to 360°.

[0064] Since the existing technology integrates OCT into a microscope, when performing ophthalmic OCT examinations, the OCT optical fiber does not directly contact the eye (the eye includes structures such as the cornea, lens, and aqueous humor), and it is necessary to scan the cornea first and then the aqueous humor. The OCT probe in this application directly penetrates deep into the eye to scan the retina, and is therefore not affected by the refractive medium.

[0065] In the embodiment shown in Figure 3, the intraocular OCT optical fiber described in the present invention also includes a sliding rod 12 and a connecting rod 16. One end of the sliding rod 12 is fixedly arranged on the outer peripheral wall of the handle housing 10; the other end of the sliding rod 12 extends upward at an angle away from the handle housing 10; one end of the connecting rod 16 is connected to the sliding rod 12, and the other end of the connecting rod 16 is connected to the optical fiber fixing shaft. By pressing the sliding rod 12, the optical fiber fixing shaft is driven to move back and forth through the connecting rod 16, thereby adjusting the length of the optical fiber 14.

[0066] In a preferred embodiment, the optical fiber fixing shaft is the rotary motor 9 .

[0067] A spring 13 is further provided on one end of the rotary motor 9 close to the optical fiber metal sleeve 6 .

[0068] The optical fiber 14 is also provided with a spiral structure on the portion located on one side of the optical fiber fixing axis.

[0069] The number of the spiral structures is zero or more.

[0070] The optical fiber 14 includes an OCT optical fiber 30 and a light guide optical fiber 8 .

[0071] By pressing the slide bar 12, the rotary motor 9 can be driven to move forward and backward via the connecting rod 16. The rotary motor 9 can drive the optical fiber 14 and the optical fiber metal sleeve 6 to move forward and backward, thereby realizing the retractable OCT optical fiber, making it convenient for doctors to adjust the working distance of the OCT optical fiber in the eye.

[0072] In the embodiment shown in Figure 4, the intraocular OCT optical fiber described in the present invention also includes a push rod 15. A sliding groove for the push rod 15 to move back and forth is provided on the outer peripheral wall of the handle shell 10. The push rod 15 is inserted into the sliding groove and one end of the push rod 15 located inside the handle shell 10 is connected to the rotary motor 9.

[0073] By moving the push rod 15 forward and backward in the direction of the double-headed arrow in Figure 4, the rotary motor 9 can be driven to move forward and backward, and the rotary motor 9 can drive the optical fiber 14 and the optical fiber metal sleeve 6 to move forward and backward, thereby realizing the retractable OCT optical fiber, making it convenient for doctors to adjust the working distance of the OCT optical fiber in the eye.

[0074] The optical fiber 14 is also provided with a spiral structure on the portion located on one side of the optical fiber fixing axis.

[0075] The number of the spiral structures is zero or more.

[0076] The optical fiber 14 includes an OCT optical fiber 30 and a light guide optical fiber 8 .

[0077] The key technical points of this application include at least:

[0078] 1. This application applies OCT optical fiber to ophthalmology.

[0079] 2. In this application, the rotary motor drives the optical fiber metal sleeve to rotate, rather than rotating the optical fiber.

[0080] 3. The scanning rotation angle of this application is 1° to 360°.

[0081] 4. This application combines OCT optical fiber and light guide fiber to solve the lighting problem.

[0082] 5. This application realizes the retractable OCT fiber optic probe.

[0083] 5 , 6 , 7 , 8 , 9 , 10 and 11 , a first aspect of the present invention provides a schematic diagram of an example of an optical fiber scanning detection system for ophthalmology.

[0084] Figure 5 is a schematic diagram of an example of an optical fiber scanning detection system for ophthalmology according to the present invention. Figure 6 is a schematic diagram of an application scenario of the optical fiber scanning detection system for ophthalmology according to the present invention.

[0085] In the application scenario of FIG6 , the fiber optic scanning detection system is used for ophthalmic detection, specifically including fundus detection, local area detection of the eyeball, fundus scanning imaging, etc. Specifically, in the example of FIG6 , a controller controls a manipulator to grab and carry the OCT scanning fiber assembly to move along a determined linear direction and / or circumferential direction, and scan and detect an object to be combined (e.g., a spherical object to be combined) to obtain a detection image of the area to be tested of the object to be combined.

[0086] It should be noted that the above is merely provided as an optional example and should not be construed as a limitation to the present invention.

[0087] As shown in Figure 5, the fiber optic scanning detection system of the present invention includes a detection device 10, an OCT scanning fiber optic component 20, a manipulator 30 and a controller 40, wherein one end of the OCT scanning fiber optic component 20 is connected to a lens structure, and one end of the OCT scanning fiber optic component 20 is also provided with a detection matching part 21.

[0088] Specifically, the detection cooperation part 21 is placed on the positioning point 51 (including a designated point in other examples) of the object to be cooperated 50 as shown in Figure 6, so that the detection cooperation part 21 of the OCT scanning optical fiber assembly 20 moves along the determined movement direction y1 and movement path L1 to complete the detection of the area to be detected.

[0089] More specifically, the object to be combined 50 is a spherical tissue, such as an eyeball. The positioning point 51 of the object to be combined 50 is, for example, a point determined according to user needs, a point determined according to the area to be detected, or a point selected by the user.

[0090] In one embodiment, the OCT scanning fiber assembly 20 is used to scan the position of the object to be combined 50 and the position of the positioning point 51. The detection device is used to automatically detect the object to be combined 50 and its positioning point 51. The detection device is, for example, an infrared light source, a position sensor, etc.

[0091] Specifically, a lens structure is connected to one end of the OCT scanning fiber assembly 20. The OCT scanning fiber assembly 20 includes a first end 24 and a second end 26 opposite the first end 24. The lens structure includes a first lens 25, whose optical axis G forms a specified angle a with the cross-section of the OCT scanning fiber assembly 20, with the specified angle a ranging from 0 to 90 degrees.

[0092] Optionally, one end (specifically, the first end 24) of the OCT scanning fiber assembly 20 is connected to the first lens 25 so that a specified angle a formed between the optical axis of the first lens 25 and the cross section of the OCT scanning fiber assembly 20 is 20 to 90 degrees. Preferably, the specified angle a is 45 degrees.

[0093] In this embodiment, the fiber optic scanning detection system further includes a manipulator 30, which is used to grasp and carry the OCT scanning fiber optic assembly 20 to scan the object 50 to be matched, and further place the OCT scanning fiber optic assembly 20 (specifically, the detection matching portion 21) at a positioning point 51 or a designated point 53 of the object 50 to be matched. The manipulator 30 has a grasping portion and a locking portion. When the grasping portion of the manipulator 30 grasps the detection matching portion 21 of the OCT scanning fiber optic assembly 20, the locking portion automatically locks the detection matching portion 21.

[0094] In order to optimize the automation and intelligence of the fiber optic scanning detection system, the fiber optic scanning detection system also includes a controller 40, which is electrically connected to the detection device 10 and the manipulator 30. The controller 40 is used to control the detection device 10 to automatically detect the object to be coordinated 50 and its positioning point 51. The controller 40 is used to control the manipulator 30 to place the OCT scanning fiber optic component 20 on the positioning point 51 or the designated point 53 of the object to be coordinated 50, so that the OCT scanning fiber optic component 20 and the object to be coordinated 50 form an implanted detection structure to detect the area to be detected of the object to be coordinated 50.

[0095] FIG. 7 is a partial side view schematically showing an angle of an example of an optical fiber scanning detection system to which the present invention is applied.

[0096] As shown in FIG7 , the controller 40 controls the manipulator 30 to place the detection and cooperation portion 21 on the object 50 (e.g., the local area Q1 of the fundus of the eye, such as the oblique lined area shown in FIG7 ) based on the detection area of ​​the object 50 to be cooperated with (e.g., the local area Q1 of the fundus of the eye, such as the oblique lined area shown in FIG7 ). The detection area (e.g., the local area Q1 of the fundus of the eye) is a curved surface area and includes a first boundary point B1 and a second boundary point B2.

[0097] FIG8 shows a partial schematic diagram of the OCT scanning optical fiber and the scanning needle of the OCT scanning optical fiber assembly in the optical fiber scanning detection system of the present invention.

[0098] As shown in FIG8 , in this embodiment, the OCT scanning fiber assembly 20 includes an OCT scanning fiber 22 and a scanning needle 23 . The OCT scanning fiber 22 is wrapped inside the scanning needle 23 , and one end of the OCT scanning fiber 22 is exposed outside the scanning needle 23 .

[0099] Specifically, the scanning needle 23 is made of various stainless steel tubes such as 304 stainless steel tube, 316 stainless steel tube, 420 stainless steel tube, 17-4PH stainless steel, nickel-titanium alloy, cobalt-chromium alloy, titanium alloy, and other alloys.

[0100] In a specific embodiment, one end of the scanning pin 23 is connected to the detection matching portion 21 so that the detection matching portion 21 is placed on the positioning point 51 or the designated point 53 of the object 50 to be matched.

[0101] Specifically, one end of the scanning pin 23 and the detection cooperation portion 21 may perform a circular motion together with a specified radius to form a scanning path formed along the szmn line as shown in FIG. 7 .

[0102] Optionally, one end of the scanning pin 23 and the detection matching portion 21 may move linearly together along a certain direction.

[0103] FIG9 is an enlarged schematic diagram of a partial structure of one end portion of an OCT scanning optical fiber assembly in the optical fiber scanning detection system for ophthalmology of the present invention.

[0104] As shown in Figure 9, in this example, one end of the OCT scanning fiber assembly 20 has a detection mating portion 21, which is, for example, a flexible mating portion connected to the first lens. The detection mating portion 21 is disposed on the exterior of the scanning needle or can be enclosed within the scanning needle. The function of the detection mating portion 21 is to be placed on the area to be inspected and to assist the first lens in better returning light reflected from the area to be inspected to the OCT scanning fiber assembly. The front end of the OCT scanning fiber assembly 20 (i.e., the end corresponding to the first end) can rotate 360 ​​degrees.

[0105] It should be noted that the above is only described as an optional example and should not be understood as a limitation to the present invention. In other embodiments, the detection cooperation portion 21 may also include other parts for scanning, detection, etc.

[0106] In addition, the controller 40 is further configured to determine the movement direction of the detection coupling portion 21 of the OCT scanning fiber assembly 20 based on the automatically detected object 50 and its positioning point 51, as well as the detection area of ​​the object 50. The positioning point is determined based on the detection area Q1 of the object 50, or a user-selected point is selected. Specifically, the positioning point is determined by the first boundary point B1 and the second boundary point B2 of the detection area Q1, and there can be one or two positioning points.

[0107] Optionally, when the area of ​​the area to be inspected is less than a specified value, the number of positioning points for the object to be coordinated is one. However, when the area of ​​the area to be inspected is greater than or equal to the specified value, the number of positioning points for the object to be coordinated is two. The specified value is, for example, within the range of 0 to 10 mm. For example, the specified value is 2 mm, which is useful when the area to be inspected is a problem area, such as the macula.

[0108] 7 , the positioning point 51 on the right side is located further away from the center O of the object 50 than the second boundary point B2 of the detection area Q1. The designated point 53 on the left side is located closer to the center O of the object 50 than the first boundary point B1 of the detection area Q1.

[0109] The detection step length Δz is expressed by the following expression.

[0110] Wherein, △z represents the scanning step length of the OCT scanning optical fiber in the optical fiber scanning detection system of the present invention in the horizontal direction, that is, the detection step length, and the unit is micrometer; λ0 represents the central wavelength of the OCT scanning light source, and the unit is nanometer; △λ represents the central spectral bandwidth of the OCT scanning light source, and the unit is nanometer; π represents pi.

[0111] It should be noted that in other examples, the position of the positioning point 51 on the right side is vertically aligned with the second boundary point B2 of the area to be detected Q1. The position of the designated point on the left side is vertically aligned with the first boundary point B1 of the area to be detected Q1. The above description is for illustrative purposes only and is not to be construed as limiting the present invention.

[0112] Specifically, the detection matching part 21 of the OCT scanning optical fiber assembly 20 and the positioning point 51 or designated point 53 of the object to be matched 50 form an implanted detection structure, and the implanted detection structure includes a detection angle formed by the detection matching part 21 and the detection area Q1 of the object to be matched 50, as shown in Figure 10.

[0113] Specifically, the detection angle a is formed by connecting the positioning point 51, the first boundary point B1, and the second boundary point B2 of the area to be detected Q1, that is, the line connecting the positioning point 51 and the first boundary point B1 and the line connecting the positioning point 51 and the second boundary point B2. The detection angle a is in the range of 20 degrees to 85 degrees. Preferably, it is in the range of 30 degrees to 75 degrees.

[0114] In a specific embodiment, the controller 40 is used to control the OCT scanning fiber assembly 20 to perform linear motion (specifically linear motion along the line segment sn) along a determined direction (for example, along a direction parallel to the line segment sn in Figure 6) to adjust the detection angle a formed by the detection matching portion 21 and the detection area Q1 of the object to be matched 50 within a set range, and complete the detection process of the detection area Q1.

[0115] In another embodiment, the controller 40 is used to control the OCT scanning optical fiber to perform linear motion along a determined direction (for example, along a direction parallel to the line segment sz in Figure 7), and then perform circular motion relative to the center O of the object to be coordinated (specifically along the curve zm) to adjust the detection angle a formed by the detection coordination portion 21 and the detection area Q1 of the object to be coordinated within a set range.

[0116] In another specific embodiment, the fiber optic scanning detection system includes a detection device, which includes an OCT infrared light source 1 and a detector 7. The detection device is connected to a reference arm 3 through a first fiber optic coupler 2 (which performs spectroscopic processing, specifically splitting the infrared light source into two beams, each with the same light intensity of 50% of the infrared light source power). The infrared light beam passes through the reference arm 3 and the sample arm 4, respectively, to the plane mirror and the positioning point of the object to be combined. Specifically, 50% of the infrared light beam passes through the reference arm 3 and is emitted through the plane mirror 5. The other 50% of the infrared light beam passes through the sample arm 4 (e.g., an OCT scanning fiber) and then scans and detects the object to be combined (e.g., an eyeball). The light beam from the reference arm 3 passes through the plane mirror 5 and returns to the first fiber optic coupler 2 along the original path. The first fiber optic coupler 2 transmits the light beam to the detector 7. The light beam from the sample arm 4 scans the object to be combined, and the light beam reflected from the object to be combined is then returned to the first fiber optic coupler 2 along the original path, and then transmitted to the detector 7. In addition, a visible light source 9 is included. For details, please refer to Figure 6.

[0117] It should be noted that the infrared light source can also be split into two beams of light with other ratios, such as a ratio of 1:10 to 9:10, by the light splitting process performed by the first fiber coupler 2. The above is merely an optional example and should not be construed as limiting the present invention.

[0118] In this embodiment, the fiber optic scanning system further includes an illumination fiber, which is used to transmit a visible light source to illuminate the area to be detected of the object to be complexed.

[0119] For example, the visible light source 9 passes through an illumination fiber and, in combination with a second fiber coupler 10, reaches the bottom of the target object, such as the base of the eyeball. This illuminates the fundus, facilitating microscopic observation of the eyeball's surface. The visible light source 9 and the scanning fiber of the sample arm 4 can be coupled via the second fiber coupler 10, or they can be two separate optical fibers secured together with a metal sleeve.

[0120] It should be noted that the above is merely provided as an optional example and should not be construed as a limitation to the present invention.

[0121] Compared with the prior art, the present invention automatically detects the object to be combined and its positioning point through the detection equipment; controls the robot arm to grab and carry the OCT scanning fiber optic assembly to scan the object to be combined through the controller, and further places the OCT scanning fiber optic assembly on the positioning point or designated point of the object to be combined to form an implanted detection structure with the object to be combined, so as to scan and detect the area to be detected of the object to be combined, which can improve the detection accuracy of the area to be detected, solve the problem of being unable to accurately detect certain areas to be detected due to the limitation of the swing range of the galvanometer, and increase the scanning detection range.

[0122] The following are examples of the method of the present invention. The fiber scanning detection system of the first aspect of the present invention is particularly suitable for the fiber scanning imaging method of the present invention. For details not disclosed in the system examples of the present invention, please refer to the system examples of the present invention.

[0123] 5, 6, 7, 10, 11 and 12, the optical fiber scanning imaging method of the present invention is performed using the optical fiber scanning detection system of the present invention.

[0124] As shown in FIG12 , the optical fiber scanning imaging method includes the following steps.

[0125] Step S101: using a detection device to automatically detect the object to be compounded and its positioning point.

[0126] For example, detection equipment such as an OCT infrared light source or a position sensor is used to automatically detect the object to be combined and its positioning point, wherein the object to be combined is, for example, an eyeball.

[0127] In an optional embodiment, the controller controls the manipulator to place the OCT scanning fiber assembly on a positioning point or a designated point of the object to be combined, so that the OCT scanning fiber assembly and the object to be combined form an implant detection structure.

[0128] Specifically, the detection matching part of the OCT scanning optical fiber assembly and the positioning point or designated point of the object to be matched form an implanted detection structure, and the implanted detection structure includes a detection angle formed by the detection matching part and the area to be detected of the object to be matched.

[0129] Step S102: Based on the area to be detected and the determined positioning point, determine the movement direction of the detection matching part of the OCT scanning optical fiber assembly relative to the area to be detected, and the movement direction includes a linear direction and / or a circumferential direction determined by the positioning point, the first edge point and the second edge point of the area to be detected.

[0130] As can be seen from Figure 6, the controller determines the movement direction of the detection matching part of the OCT scanning optical fiber assembly relative to the area to be detected Q1 and the determined positioning point 51. The movement direction includes the linear direction and / or circumferential direction determined by the positioning point, the first edge point and the second edge point of the area to be detected.

[0131] Specifically, the controller is used to control the OCT scanning fiber assembly to perform linear motion along a determined direction to adjust the detection angle formed by the detection matching portion and the area to be detected of the object to be matched to within a set range. The controller is used to control the OCT scanning fiber assembly to perform linear motion along a determined direction and then perform circular motion relative to the center of the object to be matched to adjust the detection angle formed by the detection matching portion and the area to be detected of the object to be matched to within a set range.

[0132] In a specific embodiment, the controller 40 is used to control the OCT scanning fiber assembly 20 to perform linear motion (specifically linear motion along the line segment sn) along a determined direction (for example, along a direction parallel to the line segment sn in Figure 6) to adjust the detection angle a formed by the detection matching portion 21 and the detection area Q1 of the object to be matched 50 within a set range, and complete the detection process of the detection area Q1.

[0133] In another embodiment, the controller 40 is used to control the OCT scanning fiber assembly to perform linear motion along a determined direction (for example, along a direction parallel to the line segment sz in Figure 7), and then perform circular motion relative to the center O of the object to be coordinated (specifically along the curve zm) to adjust the detection angle a formed by the detection coordination portion 21 and the detection area Q1 of the object to be coordinated to within a set range.

[0134] Step S103: The controller controls the manipulator to grab and carry the OCT scanning fiber assembly to move along the determined linear direction and / or circumferential direction, and scan and detect the object to be combined to obtain a detection image of the area to be detected of the object to be combined.

[0135] Specifically, the OCT scanning optical fiber assembly moves along the determined linear direction and / or circumferential direction, and scans and detects the object to be combined, so as to obtain a detection image of the area to be detected of the object to be combined.

[0136] Next, a preset image recognition model is used to recognize the obtained detection image to determine whether the detection image contains a target area, such as the macular area.

[0137] The preferred embodiments of the present invention are described above, but they are not intended to limit the present invention. Those skilled in the art may make improvements and changes to the embodiments disclosed herein without departing from the scope and spirit of the present invention.

Claims

1. An intraocular OCT fiber optic probe, characterized in that: The intraocular OCT fiber optic probe comprises an OCT optical fiber, an optical fiber metal sleeve, an optical fiber, a rotating motor and a handle housing, wherein the head ends of the OCT optical fiber and the optical fiber are fixedly encapsulated inside the optical fiber metal sleeve; the optical fiber metal sleeve is also connected to the rotating motor, and the optical fiber metal sleeve is driven to rotate by the rotating motor, and the head ends of the OCT optical fiber and the optical fiber are driven to rotate through the optical fiber metal sleeve; the rotating motor is electrically connected to a power cord, and the power cord provides power to the rotating motor; at least a portion of the optical fiber metal sleeve and the rotating motor are both arranged in the handle housing; the tail end of the optical fiber passes through the end of the handle housing and is connected to an illumination light source, and the optical fiber is used to provide illumination; the tail end of the OCT optical fiber passes through the end of the handle housing and is connected to an OCT inspection device, and the OCT optical fiber is used to perform an intraocular invasive OCT inspection; The OCT optical fiber comprises a single-mode optical fiber, a spring tube, a glass rod, a self-focusing lens and a reflector, wherein the single-mode optical fiber is sheathed in the spring tube; one end of the glass rod is glued to the zero-degree angle surface of the self-focusing lens, and the other end of the glass rod is glued to the single-mode optical fiber at an angle; the single-mode optical fiber, the spring tube, the glass rod, the self-focusing lens and the reflector are encapsulated in the optical fiber metal sleeve, and at least one reflective surface of the reflector forms an angle of not 90° with the optical fiber; The end of the optical fiber metal sleeve is sealed with UV glue.

2. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The gaps between the head ends of the OCT optical fiber and the optical fiber and the inner wall of the optical fiber metal sleeve are filled with adhesive.

3. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The rotary motor drives the optical fiber metal sleeve to rotate instead of directly rotating the optical fiber.

4. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The optical fiber is a multimode optical fiber.

5. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The optical fiber is a single-mode optical fiber.

6. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The rotation of the optical fiber metal sleeve enables the scanning rotation angle of the intraocular OCT optical fiber to be 1° to 360°.

7. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The optical fiber metal sleeve is a slotted stainless steel tube, and a slot is arranged on the side wall of the optical fiber metal sleeve. The reflecting surface of the reflector faces the slotted opening of the slot, which is used to reduce the influence of scattered light of the light source passing through the cylindrical inner tube of the optical fiber metal sleeve.

8. The intraocular OCT fiber optic probe according to claim 1, characterized in that: The reflector is a cylindrical reflector.

9. An optical fiber scanning detection system for ophthalmology, characterized in that: include: Detection equipment, used to automatically detect the objects to be compounded and their positioning points; An OCT scanning optical fiber assembly, one end of which is connected to a lens structure; the OCT scanning optical fiber assembly is used to scan the position of the object to be combined and the position of the positioning point; The robot is used to grab and carry the OCT scanning optical fiber assembly to scan the object to be combined, and further The OCT scanning optical fiber assembly is placed at a positioning point or a designated point of the object to be combined; a controller electrically connected to the detection device and the manipulator, the controller being used to control the detection device to automatically detect the object to be combined and its positioning point, and the controller being used to control the manipulator to place the OCT scanning optical fiber assembly at the positioning point or designated point of the object to be combined; and The OCT scanning optical fiber assembly and the object to be combined form an implantation detection structure.

10. The optical fiber scanning detection system according to claim 9, characterized in that: include: The lens structure comprises a first lens, the optical axis direction of the first lens forms a specified angle with the cross section of the OCT scanning optical fiber assembly, and the specified angle ranges from 0 degrees to 90 degrees.

11. The optical fiber scanning detection system according to claim 10, characterized in that: One end of the OCT scanning optical fiber assembly is connected to the first lens, so that the angle formed by the optical axis direction of the first lens and the cross section of the OCT scanning optical fiber assembly is 20 degrees to 90 degrees.

12. The optical fiber scanning detection system according to claim 9, characterized in that: The OCT scanning optical fiber assembly includes a detection matching portion; The controller controls the robot to place the detection matching part at a positioning point or a designated point of the object to be matched according to the area to be detected of the object to be matched.

13. The optical fiber scanning detection system according to claim 12, characterized in that: include: The detection matching part of the OCT scanning optical fiber assembly and the positioning point or designated point of the object to be matched form an implanted detection structure, and the implanted detection structure includes a detection angle formed by the detection matching part and the area to be detected of the object to be matched.

14. The optical fiber scanning detection system according to claim 13, characterized in that: The controller is also used to determine the movement direction of the detection matching part of the OCT scanning optical fiber assembly according to the automatically detected object to be matched and its positioning point, and the area to be detected of the object to be matched.

15. The optical fiber scanning detection system according to claim 14, characterized in that: The controller is used to control the OCT scanning optical fiber assembly to move linearly along the determined direction to adjust the detection angle formed by the detection matching part and the detection area of ​​the object to be matched to be within a set range; or The controller is used to control the OCT scanning optical fiber assembly to perform linear motion along the determined direction and then perform circular motion relative to the center of the object to be matched, so as to adjust the detection angle formed by the detection matching part and the detection area of ​​the object to be matched within a set range.

16. The optical fiber scanning detection system according to claim 9, characterized in that: The object to be coordinated is a sphere; The optical fiber scanning system further comprises an illumination optical fiber, which is used to transmit a visible light source to illuminate a region to be detected of the object to be combined.

17. A fiber optic scanning imaging method for ophthalmology, which is performed by using the fiber optic scanning detection system according to any one of claims 9 to 16, characterized in that: The optical fiber scanning imaging method comprises: Use detection equipment to automatically detect the objects to be compounded and their positioning points; According to the area to be detected and the determined positioning point, determine the movement direction of the detection matching part of the OCT scanning optical fiber assembly relative to the area to be detected, wherein the movement direction includes a linear direction and / or a circumferential direction determined by the positioning point, the first edge point and the second edge point of the area to be detected; The controller controls the manipulator to grab and carry the OCT scanning optical fiber assembly to move along the determined linear direction and / or circumferential direction, and scans and detects the object to be combined to obtain a detection image of the area to be detected of the object to be combined.

18. The optical fiber scanning imaging method according to claim 17, characterized in that: Also includes: The controller controls the manipulator to place the OCT scanning optical fiber assembly on a positioning point or a designated point of the object to be combined, so that the OCT scanning optical fiber assembly and the object to be combined form an implantation detection structure.

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