Composition, dry reagent, and method for preserving composition

A trehalose and water-based composition stabilizes reactive components in dry reagents, addressing enzyme deterioration and maintaining activity for slide-type dry chemistry applications, enhancing storage stability and usability.

WO2025205239A1 Publication Date: 2025-10-02TOKUYAMA CORP
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Patent Information

Application Number
PCT/JP2025/010447
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-03-28
Filing Date
2025-03-18
Publication Date
2025-10-02

AI Technical Summary

Technical Problem

Existing dry reagents for clinical testing and biochemical research face challenges in maintaining enzyme activity and stability due to enzyme deterioration, especially when moisture is present, which affects their performance and usability, particularly in slide-type dry chemistry technology.

Method used

A composition comprising trehalose and water in specific ratios (0.2% to 90% by weight of trehalose and 1% to 30% by weight of water) that stabilizes reactive components, allowing storage at room temperature and maintaining enzyme activity by preventing structural reorganization during drying.

Benefits of technology

The composition achieves excellent storage stability with minimal enzyme activity loss, enabling use in slide-reagent-type dry chemistry techniques and point-of-care testing at room temperature.

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Abstract

A composition according to one aspect of the present disclosure comprises: a reaction component which reacts with a target component that is contained in a biological sample and that is a target for measurement; trehalose; and water. The composition contains 0.2-90 wt% of trehalose and 1-30 wt% of water with respect to the total weight of the composition, and the weight of the water is not more than 5 times the weight of the trehalose.
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