Oral care compositions

Abstract

Oral care compositions and, particularly, mouthwashes and concentrated mouthwashes are disclosed herein. In accordance with an aspect of the invention, provided is a concentrated mouthwash composition comprising from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; optionally, an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

Description

ORAL CARE COMPOSITIONSCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of priority from U.S. Provisional Patent Application No. 63 / 634,595, filed April 16, 2024, titled ORAL CARE COMPOSITIONS, which is hereby incorporated herein by reference in its entirety for all purposes.BACKGROUND

[0002] It has been observed that the majority of conventional mouthwash formulations contain a high percentage of ethanol, with concentrations ranging from about 10 to 30 wt.%. The ethanol is used not only as a disinfectant, but also as a solvent to dissolve additives (such as, flavor oils) which are insoluble in water. A need still exists for an alcohol-free aqueous oral care composition which contains a high level of water-insoluble flavoring agent.BRIEF SUMMARY

[0003] This summary is intended merely to introduce a simplified summary of some aspects of one or more implementations of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.

[0004] Aspects of the invention are directed oral care compositions and, particularly, mouthwashes and concentrated mouthwashes. In accordance with an aspect of the invention, provided is a concentrated mouthwash composition comprising from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

[0005] In accordance with another aspect of the invention, provided is an oral care composition comprising from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; arginine and / or a salt thereof; from about 1 to about 10 wt.% of nonionic surfactant; a hydrogenatedcastor oil; wherein the oral care composition is a single-phase mouthwash, and all weight percentages arc based on the total weight of the oral care composition.

[0006] In accordance with an aspect of the invention, provided is a mouthwash composition comprising from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

[0007] In according with a further aspect of the invention, provided is a method for manufacturing an oral care composition, the method comprising mixing from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil.

[0008] A non-limiting list of exemplary embodiments in accordance with aspects of the invention is provided below:

[0009] In accordance with an embodiment 1, provided is a concentrated mouthwash composition comprising: from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

[0010] In accordance with an embodiment 2, provided is the concentrated mouthwash composition according to embodiment 1 further comprising a hydrogenated castor oil.

[0011] In accordance with an embodiment 3, provided is the concentrated mouthwash composition according to embodiment 2, wherein the hydrogenated castor oil comprises a pegylated hydrogenated castor oil.

[0012] In accordance with an embodiment 4, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the polyol comprises glycerin and propylene glycol.

[0013] In accordance with an embodiment 5, provided is the concentrated mouthwash composition according embodiment 4, wherein the concentrated mouthwash composition has a weight ratio of propylene glycol to glycerin of about 2:1 to about 1:3.

[0014] In accordance with an embodiment 6, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the amino acid consists of arginine, lysine, a saltthereof or a combination of two or more thereof.

[0015] In accordance with an embodiment 7, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the amino acid comprises arginine and / or a salt thereof.

[0016] In accordance with an embodiment 8, provided is the concentrated mouthwash composition according to any foregoing embodiment further comprising a carbonate and / or bicarbonate.

[0017] In accordance with an embodiment 9, provided is the concentrated mouthwash composition according to any foregoing embodiment further comprising sodium bicarbonate.

[0018] In accordance with an embodiment 10, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the nonionic surfactant comprises a poloxamer, a sorbitan surfactant, or a combination of two or more thereof.

[0019] In accordance with an embodiment 11, provided is the concentrated mouthwash composition according to embodiment 10, wherein the nonionic surfactant comprises a sorbitan surfactant selected from ethoxylated sorbitan surfactants.

[0020] In accordance with an embodiment 12, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the concentrated mouthwash composition is essentially free or free of hydrocarbon oils.

[0021] In accordance with an embodiment 13, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the concentrated mouthwash composition is essentially free or free of monoalcohols.

[0022] In accordance with an embodiment 14, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the concentrated mouthwash composition is essentially free or free of anionic surfactants.

[0023] In accordance with an embodiment 15, provided is the concentrated mouthwash composition according to any foregoing embodiment, wherein the concentrated mouthwash composition is free of surfactants other than nonionic surfactants.

[0024] In accordance with an embodiment 16, provided is the concentrated mouthwash composition according to any foregoing embodiment further comprising a sweetener, optionally, in an amount from about 0.1 to about 7 wt.%.

[0025] In accordance with an embodiment 17, provided is the concentrated mouthwash composition according to embodiment 16, wherein the sweetener is selected from sucrose, lactose,maltose, sorbitol, xylitol, sodium cyclamate, perillartine, L-aspartyl-L-phenylalanine methyl ester, saccharine, and a combination of two or more thereof.

[0026] In accordance with an embodiment 18, provided is the concentrated mouthwash composition according to any foregoing embodiment further comprising a fluoride source, optionally, in an amount from about 0.1 to about 2 wt.%.

[0027] In accordance with an embodiment 19, provided is the concentrated mouthwash composition according to embodiment 18, wherein the fluoride source is selected from sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof.

[0028] In accordance with an embodiment 20, provided is an oral care composition comprising: from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; arginine and / or a salt thereof; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil, wherein the oral care composition is a single-phase mouthwash, and all weight percentages are based on the total weight of the oral care composition.

[0029] In accordance with an embodiment 21, provided is a method of manufacturing an oral care composition comprising: mixing from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil.

[0030] In accordance with an embodiment 22, provided is the method according to embodiment 21 comprising manufacturing an oral care composition according to any one of embodiments 1 to 20.

[0031] In accordance with an embodiment 23, provided is an oral care composition comprising: from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil, wherein the oral care composition is a single-phase mouthwash, and all weight percentages are based on the total weight of the oral care composition.DETAILED DESCRIPTION

[0032] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of theinvention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles arc equally applicable to, and can be employed in other compositions and methods. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is for the purpose of description and not of limitation.

[0033] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular’ form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0034] As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. Thus, a range from 1-5, includes specifically 1, 2, 3, 4 and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0035] The term “about” when referring to a number means any number within a range of 10% of the number. For example, the phrase “about 2 wt.%” refers to a number between and including 1.8 wt.% and 2.2 wt.%.

[0036] All references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0037] The abbreviations and symbols as used herein, unless indicated otherwise, take their ordinary meaning. The abbreviation “wt.%” means percent by weight with respect to the oral care composition. The symbol “°” refers to a degree, such as a temperature degree or a degree of an angle. The symbols “h”, “min”, “mL”, “nm”, and “pm” refer to hour, minute, milliliter, nanometer, and micrometer, respectively. The abbreviation “UV-VIS” referring to a spectrometer or spectroscopy, means Ultraviolet- Visible. The abbreviation “rpm” means revolutions per minute.

[0038] When referring to chemical structures, and names, the symbols “C”, “H”, and “O” mean carbon, hydrogen, and oxygen, respectively. The symbols “=” and “= ’ mean single bond, double bond, and triple bond, respectively.

[0039] “Volatile”, as used herein, means having a flash point of less than about 100° C. “Nonvolatile”, as used herein, means having a flash point of greater than about 100° C.

[0040] Any member in a list of species that are used to exemplify or define a genus, may be mutually different from, or overlapping with, or a subset of, or equivalent to, or nearly the same as, or identical to, any other member of the list of species. Further, unless explicitly stated, such as when reciting a Markush group, the list of species that define or exemplify the genus is open, and it is given that other species may exist that define or exemplify the genus just as well as, or better than, any other species listed.

[0041] The phrases, “a mixture thereof,” “a combination thereof,” or a combination of two or more thereof’ do not require that the mixture include all of A, B, C, D, E, and F (although all of A, B,C, D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C,D, E, and F can be included. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture of any two or more of A, B, C, D, E, and F.” Likewise, the term “a salt thereof” also relates to “salts thereof.” Thus, where the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0042] All components and elements positively set forth in this disclosure can be negatively excluded from the claims. In other words, the oral care compositions and / or the oral care compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure. In some instances, the oral care compositions and / or oral care compositions of the present disclosure may be substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound that is added into the oral care compositions and / or the oral care composition by itself. For example, an oral care composition and / or an oral care composition may be substantially free of a non-incidentalamount of an ingredient or compound, although such ingredient(s) or compound(s) may he present as part of a raw material that is included as a blend of two or more compounds.

[0043] Some of the various categories of components identified may overlap. In such cases where overlap may exist and the oral care composition and / or the oral care composition includes both components (or the oral care composition and / or the oral care composition includes more than two components that overlap), an overlapping compound does not represent more than one component. For example, certain compounds may be characterized as both a polyol and a sweetener. If a particular the oral care composition and / or oral care composition recites both a polyol and a sweetener, xylitol will serve only as either a polyol or a sweetener — not both.

[0044] For readability purposes, the chemical functional groups are in their adjective form; for each of the adjectives, the word “group” is assumed. For example, the adjective “alkyl” without a noun thereafter, should be read as “an alkyl group.”

[0045] Aspects of the invention are directed oral care compositions and, particularly, mouthwashes and concentrated mouthwashes. In accordance with an aspect of the invention, provided is a concentrated mouthwash composition comprising from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

[0046] In accordance with another aspect of the invention, provided is an oral care composition comprising from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; arginine and / or a salt thereof; from about 1 to about 10 wt.% of nonionic surfactant; a hydrogenated castor oil; wherein the oral care composition is a single-phase mouthwash, and all weight percentages are based on the total weight of the oral care composition.

[0047] In accordance with an aspect of the invention, provided is a mouthwash composition comprising from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

[0048] Preferably, the oral care compositions may have a reduced amount of monoalcohols, such as ethanol, propanol, butanol, etc. The amount of monoalcohols present in the oral care composition may be about 5 wt.% or less, about 4 wt.% or less, about 3 wt.% or less, about 2 wt.%or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0. 1 wt.% or less, based on the total weight of the oral care composition. In at least one embodiment, the oral care composition has about 0.5 wt.% or less or less of monoalcohols. In some embodiments, the oral care composition is substantially free of or free of monoalcohols.

[0049] Additionally or alternatively, the oral care compositions may have a reduced amount of oils, such as hydrocarbon oils. For example, the amount of oil (e.g., hydrocarbon oils) present in the oral care composition may be about 5 wt.% or less, about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less, based on the total weight of the oral care composition. In at least one embodiment, the oral care composition has about 0.5 wt.% or less or less of hydrocarbon oils. In at least one embodiment, the oral care composition has about 0.5 wt.% or less or less of oils. In some embodiments, the oral care composition is substantially free of or free of oils, such as hydrocarbon oils.

[0050] The oral care compositions may be in the form of dentifrice, toothpaste, mouthwash, and / or the like. In some preferred embodiments, the oral care composition is in the form of a mouthwash and / or a concentrated mouthwash. Suitable components, such as those listed below, may be included or excluded from the formulations for the oral care compositions depending on the specific combination of other ingredients and the form of the oral care compositions. Additionally or alternatively, the oral care compositions may in some embodiments have a single phase, which contains the components and / or ingredients of the oral care composition. In other embodiments, the oral care composition may include two or more phases, such as two, three, four, or five phases.

[0051] The oral care composition, preferably, comprises an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof. The oral care composition may comprises arginine in free form, e.g., L-arginine. Additionally and / or alternatively, the oral care composition may include, or in some cases exclude, arginine and / or lysine in the form of a salt, e.g., arginine bicarbonate. In certain embodiments, the oral care composition has amino acid(s) consisting of arginine, lysine, a salt thereof or a combination of two or more thereof. In at least one embodiment, the oral care composition has amino acid(s) comprising or consisting of arginine and / or a salt thereof. Additional amino acids that may be included or excluded from certain embodiments of the oral care composition include, e.g., citrullene, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid, salts thereof or combinations thereof. In some embodiments, however, the oral care composition is essentially free of or free of arginine, lysine,and / or amino acids.

[0052] The amount of amino acid (c.g., arginine, lysine, etc.) in the oral care composition may be from about 0.005 to about 2 wt.%, based on the total weight of the oral care composition as calculated as free base form. For example, the oral care composition may include amino acid in an amount, as calculated as free base form, from about 0.005 to about 1.6 wt.%, about 0.005 to about 1.2 wt.%, about 0.005 to about 0.4 wt.%, about 0.005 to about 0.2 wt.%, about 0.005 to about 0.1 wt.%, about 0.005 to about 0.08 wt.%, about 0.005 to about 0.05 wt.%, about 0.005 to about 0.02 wt.%; from about 0.01 to about 2 wt.%, about 0.01 to about 1.2 wt.%, about 0.01 to about 0.4 wt.%, about 0.01 to about 0.2 wt.%, about 0.01 to about 0.1 wt.%, about 0.01 to about 0.08 wt.%, about 0.01 to about 0.05 wt.%, about 0.01 to about 0.02 wt.%; from about 0.02 to about 2 wt.%, about 0.02 to about 1.2 wt.%, about 0.02 to about 0.4 wt.%, about 0.02 to about 0.2 wt.%, about 0.02 to about 0.1 wt.%, about 0.02 to about 0.08 wt.%, about 0.02 to about 0.05 wd.%; from about 0.05 to about 2 wt.%, about 0.05 to about 1.2 wt.%, about 0.05 to about 0.4 wt.%, about 0.05 to about 0.2 wt.%, about 0.05 to about 0.1 wt.%, about 0.05 to about 0.08 wt.%; from about 0.1 to about 2 wt.%, about 0.1 to about 1.6 wt.%, about 0.1 to about 1.2 wt.%, about 0.1 to about 0.8 wt.%, about 0.1 to about 0.4 wt.%, about 0.1 to about 0.2 wt.%; from about 0.4 to about 2 wt.%, about 0.4 to about 1.6 wt.%, about 0.4 to about 1.2 wt.%, about 0.4 to about 0.8 wt.%; from about 0.8 to about 2 wt.%, about 0.8 to about 1.6 wt.%, about 0.8 to about 1.2 wt.%, about 1.5 to about 2 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0053] The oral care compositions also comprise one or more polyol(s). The amount of polyol(s) in the oral care composition may be from about 50 to about 85 wt.%, based on the total weight of the oral care composition. In some cases, the oral care composition comprises a total amount of polyol(s) of about 50 to about 85 wt.%, about 50 to about 80 wt.%, about 50 to about 75 wt.%, about 50 to about 70 wt.%, about 50 to about 65 wt.%, about 50 to about 60 wt.%; from about 60 to about 85 wt.%, about 60 to about 80 wt.%, about 60 to about 75 wt.%, about 60 to about 70 wt.%, about 60 to about 65 wt.%; from about 65 to about 85 wt.%, about 65 to about 80 wt.%, about 65 to about 75 wt.%, about 65 to about 70 wt.%; from about 70 to about 85 wt.%, about 70 to about 80 wt.%, about 70 to about 75 wrt.%; from about 75 to about 85 wt.%, about 75 to about 80 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition. In at least one embodiment, the total amount of polyols in the oral care composition is from about 65 to about 77 wt.% or about 68 to about 74 wt.%, based on the total weight of the oral carecomposition.

[0054] The polyol(s) may be chosen from glycols or compounds with numerous hydroxyl groups. The one or more polyols may be liquid at ambient temperature (25 °C). In some preferred embodiments, the polyol(s) comprises glycerin, glycol, inositol, maltitol, mannitol, sorbitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), a block copolymer of PPG and PEG, a saccharide (e.g., fructose, glucose, sucrose and mixtures of saccharides, such as honey), or a combination of two or more thereof. For instance, the oral care composition may comprise maltitol, mannitol, sorbitol, xylitol, a polypropylene glycol (PPG), a polyethylene glycol (PEG), a block copolymer of PPG and PEG, or a combination or two or more thereof. The polyol may be a humectant including, e.g., glycol, sorbitol, glycerin, inositol, maltitol, mannitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), a saccharide, polyoxypropylene-polyoxyethylene block copolymer, and a combination of two or more thereof.

[0055] In some cases, the oral care composition includes one or more polyol selected from the group consisting of C2-C32 polyols. The one or more polyols may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms, or from 3 to 12 carbon atoms. For example, the oral care composition may comprise ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol, or a combination of two or more thereof. Additional, non-limiting examples of polyols that may, optionally, be included in the oral care include and / or may be chosen from alkanediols such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene- 1 ,4-diol, 2-ethyl- 1 ,3-hexanediol, 2-methyl-2,4-pentanediol, caprylyl glycol, 1 ,2-hexanediol, 1 ,2-pentanediol, and 4-methyl-l,2-pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1 -methyl- 1 -methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t- butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether,dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylcnc glycol mono-iso-propyl ether, sorbitol, sorbitan, triacctin, and a mixture of two or more thereof.

[0056] Additionally or alternatively, the oral care composition may include polyol(s) having a molecular weight of from about 100 to 5000 g / mol. For instance, the polyol may comprise a polyethylene glycol, a polypropylene glycol, a block polymer of polyethylene glycol and polypropylene glycol, or a combination of two or more thereof. In some embodiments, the polyol comprises a polypropylene glycol, a polypropylene glycol, and / or a block polymer of polyethylene glycol and polypropylene glycol having a molecular weight of about 100 to about 900, about 200 to about 800, about 400, about 1500 to about 2500, about 2000 to about 4500 or any range or subrange thereof. In some embodiments, the polyol is a polyethylene glycol, such as polyethylene glycol 600. In some embodiments, the oral care composition comprises one or more polyethylene glycols, e.g., polyethylene glycols in a molecular weight range from 200 to 800. For example, the oral care compositions may comprise one or more of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol, 600 or polyethylene glycol 800. In certain embodiments, the oral care composition includes polyol(s) selected from the group consisting of glycerin, propylene glycol, and a combination thereof.

[0057] In certain embodiments, the oral care composition comprises two or more polyols. In at least one embodiment, the oral care composition comprises propylene glycol and glycerin. In some instances, the polyols consist of propylene glycol and glycerin. The oral care compositions may, in some preferred embodiments, have a polyol system comprising propylene glycol and glycerin in a weight ratio of propylene glycol to glycerin of about 2:1 to about 1:3. For instance, the oral care composition may have a weight ratio of propylene glycol to glycerin of about 2: 1 to about 1:3, about 1:1 to about 1:3; from about 1: 1.25 to about 1 :3, about 1 :1.5 to about 1 :3, about 1 : 1.75 to about 1 :3, about 1 :2 to about 1 :3; from about 1 : 1 to about 1:2.5, about 1 : 1.25 to about 1 :2.5, about 1: 1.5 to about 1:2.5, about 1: 1.75 to about 1 :2.5, about 1 :2 to about 1 :2; from about 1:1 to about 1 :2, about 1 : 1.25 to about 1 :2, about 1 : 1.5 to about 1 :2, about 1 : 1.75 to about 1 :2; from about 1 : 1 to about 1:1.5, about 1 : 1.25 to about 1:1.5, about 1 : 1 to about 1 : 1.25, or any range or subrange thereof.

[0058] The oral care compositions typically comprise one or more surfactant(s), e.g., in an amount from about 1 to about 10 wt.%, based on the total weight of the oral care composition. For instance,the oral care composition may comprise a total amount of surfactant(s) of about 1 to about 8 wt.%, about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 4 to about 10 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 10 wt.%, about 5 to about 8 wt.%, about 5 to about 7 wt.%, about 5 to about 6 wt.%; from about 6 to about 10 wt.%, about 6 to about 8 wt.%; from about 7 to about 10 wt.%, about 7 to about 9 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0059] The one or more surfactant(s) may be selected from anionic surfactants, amphoteric surfactants, nonionic surfactants, or combinations of two or more thereof. The one or more surfactant(s) preferably comprises at least one nonionic surfactant. In certain embodiments, the oral care composition is free of surfactants other than nonionic surfactants. The one or more nonionic surfactant(s) may be selected from sorbitan surfactants, poloxamers, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides, glucosides, and / or compounds produced by the condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound, which may be aliphatic or alkylaromatic in nature. For example, the nonionic surfactants may be selected from sorbitan surfactants, poloxamers, or a combination of two or more thereof. In some embodiments, oral care composition comprises one or more sorbitan surfactant and one or more poloxamers. In at least one embodiment, the only surfactants in the oral care composition are nonionic surfactants selected from sorbitan surfactants, poloxamers, or a combination of two or more thereof.

[0060] The sorbitan surfactants may be an alkoxylate and / or an ethoxylate. In some embodiments, the nonionic surfactants are selected from the group consisting of alkoxylated sorbitan surfactants. The nonionic surfactants may be selected from the group consisting of ethoxylated sorbitan surfactants. In some embodiments, the oral care composition comprises one or more sorbitan surfactants, such as those selected from ethoxylated sorbitan surfactants, polyoxyethylene esters, polyoxyethylene sugar alcohol and dehydrated sugar alcohol esters, or a combination of two or more thereof. In certain embodiments, the oral care composition may include, or in some instances exclude, one or more of polysorbate 80, polysorbate 20, polysorbate 40, polysorbate 60,polysorbate 65, polysorbate 81, or polysorbate 85. For example, in certain embodiments, the sorbitan surfactants may comprise, or consist of, polysorbate 80 and / or polysorbate 20.

[0061] The nonionic surfactant may be selected from poloxamers, a triblock copolymer of a central of polypropylene glycol and two flanking locks of polyethylene glycol (PEG). The pol oxamer may have an average molecular weight between 7680 and 9510 g / mol and / or have a structure according to the following formula:where a may independent be from 5 to 150, preferably from 60 to 95 or from 70 to 90, and b may be 15 to 67, preferably 20 to 40 or 24 to 30. Non-limiting examples of poloxamers include poloxamer 188, poloxamer 407, poloxamer 237, poloxamer 338, or a combination thereof.

[0062] Examples of glucoside surfactants include decyl glucoside, stearyl glucoside, lauryl glucoside, coco-glucoside, cetearyl glucoside, decyl lauryl glucoside, lauroyl ethyl glucoside, myristoyl ethyl glucoside, oleoyl ethyl glucoside, or a combination of two or more thereof. The poloxamer may be poloxamer 407, poloxamer 188, or a combination thereof. Additional nonionic surfactants that are worth mentioning include fatty alcohol ethoxylates, alcohol ethoxylate (AEO or AE), carboxylated alcohol ethoxylates, nonylphenol ethoxylate, and alkylphenol ethoxylates.

[0063] Further examples of nonionic surfactants include polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethylene oxide condensates of aliphatic alcohols, acids, and esters, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides and mixtures of such materials. Additional examples of nonionic surfactants include polyoxyethylene, polyoxyethylene sorbitan esters, polyoxyl 40 hydrogenated castor oil, fatty alcohol ethoxylates, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides, or a combination of two or more thereof. In some instances, the nonionic surfactant comprises amine oxides, fatty acid amides, ethoxylated fatty alcohols, block copolymers of polyethylene glycol and polypropylene glycol, glycerol alkylesters, polyoxyethytene glycol octylphenol ethers, sorbitan alkyl esters, polyoxyethylene glycol sorbitan alkyl esters, or a combination of two or more thereof. In some embodiments, one or more of the above nonionic surfactants may be excluded from the oral care composition.

[0064] The oral care composition may comprise one or more anionic surfactant, wherein the anionic surfactants consist of non-sulfate based anionic surfactant. Preferably, the oral care compositions may have a reduced amount of sulfate based anionic surfactants. The amount of sulfate based anionic surfactants present in the oral care composition may be about 5 wt.% or less, about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less, based on the total weight of the oral care composition. In some embodiments, the oral care composition is substantially free of or free of sulfate based anionic surfactants.

[0065] The oral care compositions may a reduced amount, be essentially free of, or free of anionic surfactants. The amount of anionic surfactants present in the oral care composition may be about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less, based on the total weight of the oral care composition. In some embodiments, the oral care composition is substantially free of or free of anionic surfactants.

[0066] The oral care composition may include, or in some embodiments exclude, one or more amphoteric surfactants, such as those having a substituent containing 8 to 18 carbon atoms and a substituent containing one or more carboxylate, sulfonate, sulfate, phosphate, or phosphonate. Examples of amphoteric surfactants include those having an alkyl group comprising from 8 to 20 carbon atoms, 8 to 16 carbon atoms, 10 to 16 carbon atoms, or 10 to 13 carbon atoms. The amphoteric surfactant(s) may include, but are not limited to, derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight chain or branched. In some cases, one of the aliphatic substituents of the amphoteric surfactant contains about 8 to about 18 carbon atoms and one of the aliphatic substituents contains an anionic water solubilizing group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate. The amphoteric surfactants disclosed herein may be present in the oral care composition in a salt form.

[0067] The amphoteric surfactants may be selected from alkyl amphopropionates, betaines, alkyl sultaines, alkyl amphoacetates, or a combination of two or more thereof. In some cases, the amphoteric surfactant is selected from betaine surfactants. Examples of betaine surfactants include, e.g., alkyl betaines, such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxy-methylbetaine, lauryl dimethyl alpha-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxycthyl)carboxy methyl betaine, stcaryl bis-(2-hydroxypropyl)carboxymcthyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl)alpha- carboxyethyl betaine. In some embodiments, one or more of the above amphoteric surfactants may be excluded from the oral care composition.

[0068] The oral care compositions may a reduced amount, be essentially free of, or free of amphoteric surfactants. The amount of amphoteric surfactants present in the oral care composition may be about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less, based on the total weight of the oral care composition. In some embodiments, the oral care composition is substantially free of or free of amphoteric surfactants.

[0069] The oral care compositions may a reduced amount, be essentially free of, or free of cationic surfactants. The amount of cationic surfactants present in the oral care composition may be about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less, based on the total weight of the oral care composition. In some embodiments, the oral care composition is substantially free of or free of cationic surfactants.

[0070] The oral care composition typically comprises water. The amount of water in the oral care composition may be from about 5 to about 30 wt.%, based on the total weight of the oral care composition. In some embodiments, the amount of water is from about 5 to about 30 wt.%, about 5 to about 27 wt.%, about 5 to about 24 wt.%, about 5 to about 21 wt.%, about 5 to about 17 wt.%, about 5 to about 14 wt.%; from about 8 to about 30 wt.%, about 8 to about 27 wt.%, about 8 to about 24 wt.%, about 8 to about 21 wt.%, about 8 to about 17 wt.%, about 8 to about 14 wt.%; from about 11 to about 30 wt.%, about 11 to about 27 wt.%, about 11 to about 24 wt.%, about 11 to about 21 wt.%, about 11 to about 17 wt.%, about 11 to about 14 wt.%; from about 14 to about 30 wt.%, about 14 to about 27 wt.%, about 14 to about 24 wt.%, about 14 to about 21 wt.%; from about 17 to about 30 wt.%, about 17 to about 27 wt.%, about 17 to about 24 wt.%, about 17 to about 21 wt.%; from about 21 to about 30 wt.%, about 21 to about 27 wt.%, about 21 to about 24 wt.%; from about 24 to about 30 wt.%, about 24 to about 27 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0071] In certain preferred embodiments, the oral care composition includes a hydrogenated castor oil. For example, the hydrogenated castor oil may comprise a pegylated hydrogenated castor oil. The length of the PEG chain may be from about 10 to about 80, about 10 to about 60, about 10 toabout 40; from about 20 to about 80, about 20 to about 60, about 20 to about 40; from about 30 to about 80, about 30 to about 60, about 30 to about 40; from about 40 to about 80, about 40 to about 60, about 40 to about 50, or any range or subrange thereof.

[0072] The amount of hydrogenated castor oil present in the oral care composition may be from about 1 to about 8 wt.%, based on the total weight of the oral care composition. For instance, the oral care composition may comprise a total amount of surfactant(s) of about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%; from about 2 to about 8 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 4 to about 8 wt.%, about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 8 wt.%, about 5 to about 7 wt.%, about 5 to about 6 wt.%, about 6 to about 8 wt.% or any range or subrange thereof, based on the total weight of the oral care composition.

[0073] The oral care composition may include one or more carbonate and / or bicarbonate. The carbonate and / or bicarbonate may be selected from sodium bicarbonate, sodium carbonate calcium bicarbonate, calcium carbonate, calcium bicarbonate, potassium carbonate, potassium bicarbonate, or a combination of thereof. The total amount of carbonate and / or bicarbonate in the oral care composition may be from about 0.01 to about 2 wt.%, based on the total weight of the oral care composition. For example, the total amount of carbonate and / or bicarbonate present in the oral care composition may be from about 0.01 to about 1.5 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; from about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%, about 1 to about 2 wt.%, or any range or subrange thereof, based on the total weight of the oral are composition.

[0074] The oral care compositions may include a fluoride ion source. The fluoride ion source may be present in an effective amount. In some cases, the fluoride ion source is present in the oral care composition in an amount of about 0.01 to about 2 wt.%, based on the total weight of the oral care composition. For example, the fluoride ion source may be present in an amount of from about 0.01 to about 1.5 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; from about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%, about 1 to about 2 wt.%, or any range or subrange thereof, based on the total weight of the oral are composition.

[0075] The fluoride ion source may be selected from soluble fluoride ion salts. For example, the fluoride ion source may comprise sodium fluoride, potassium fluoride, calcium fluoride, zinc fluoride, zinc ammonium fluoride, lithium fluoride, ammonium fluoride, sodium monofluorophosphate, potassium monofluorophosphate, laurylamine hydrofluoride, diethylaminoethyloctoylamide hydrofluoride, didecyldimethylammonium fluoride, cetylpyridinium fluoride, dilaurylmorpholinium fluoride, sarcosine glycine potassium fluoride, glycine hydrofluoride, amine fluorides or a combination of two or more thereof. In some embodiments, the fluoride ion source comprises sodium fluoride, sodium monofluorophosphate, or a combination thereof. Additional examples of fluoride ion source are disclosed in U.S. Patent No. 3,535,421, U.S. Patent No. 4,885,155, and U.S. Patent No. 3,678,154, the disclosure of each of which is hereby incorporated by reference in their entirety.

[0076] In some embodiments, the oral care compositions may include one or more sweeteners. The oral care composition may include caloric sweeteners and / or non-caloric sweeteners. Examples of non-caloric sweeteners include saccharin, for example, sodium saccharin, acesulfame, neotame, cyclamate or sucralose; natural high-intensity sweeteners, such as thaumatin, stevioside or glycyrrhizin; or sugar alcohols, such as sorbitol, xylitol, maltitol and mannitol. Examples of caloric sweeteners include sugars, such as fructose, glucose, sucrose, and high fructose syrups.

[0077] The one or more sweetener(s) may be present in the oral care composition in an amount of about 0.1 to about 7 wt.%, based on the total weight of the oral care composition. For example, the sweetener(s) may be present in an amount of about 0.1 to about 7 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.4 to about 7 wt.%, about 0.4 to about 5 wt.%, about 0.4 to about 3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1 wt.%; from about 0.8 to about 7 wt.%, about 0.8 to about 5 wt.%, about 0.8 to about 3 wt.%, about 0.8 to about 2 wt.%, about 0.8 to about 1.5 wt.%; from about 1.4 to about 7 wt.%, about 1.4 to about 5 wt.%, about 1.4 to about 3 wt.%; from about 2 to about 7 wt.%, about 2 to about 5 wt.%, about 2 to about 3 wt.%; from about 3 to about 7 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 7 wt.%, about 5 to about 6 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0078] In some embodiments, the oral care composition preferably is substantially free or free ofcaloric sweeteners. For example, the oral care compositions may have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less, based on the weight of the oral care composition. In at least one embodiment, the oral care composition contains about 0 wt.% or 0 wt.% of caloric sweeteners, based on the weight of the oral care composition.

[0079] The oral care compositions of the present disclosure may include a flavoring agent. The flavoring agent is typically incorporated in the oral care composition at a concentration of about 0.01 to about 3 wt.% by weight of the oral care composition. For example, the amount of flavoring agent(s) present in the oral care composition may be from about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; from about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 3 wt.%, including any range or subrange thereof, based on the total weight of the oral care composition.

[0080] Suitable flavoring agents include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and similar materials. Examples of the essential oils include oils of spearmint, peppermint, Wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethole. Additional flavoring agents may include, but are not limited to menthol, artificial vanilla, cinnamon derivatives, and various fruit flavors, spearmint oil, peppermint oil, cinnamon oil, oil of Wintergreen (methylsalicylate), clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, oil of bitter almonds, cassia oil, and a combination of two or more thereof.

[0081] The oral care compositions may include one or more colorants. Exemplary colorants can include natural or uncertified colors from natural sources or certified colors for the effect of color. In some embodiments, the colorant can include dyes, certified aluminum lakes or colors derived from a natural source. The colorant may be water-based, oil-based or dry. The colorants can be primary colors, blends of colors or discrete mixtures of colors, such as confetti. The concentrations of the colorant in the oral care composition may be from trace amount to about 0.6 wt.%, from about 0.1 to about 0.5 wt.%, about 0.2 to about 0.4 wt.%, or about 0.15 to about 0.35 wt.%, based on the total weight of the oral care composition.

[0082] The oral care composition may include one or more pH adjusters to increase or decrease the overall pH of the oral care composition. For example, one or more acids may be included to decrease the pH of the oral care composition. Examples of suitable acids for decreasing the pH of the oral care composition include, but are not limited to, citric acid, acetic acid, and the like. The oral care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide and the like, to increase the pH of the oral care composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the oral care composition are readily known to one of ordinary skill in the art.

[0083] The amount of the pH adjuster in the oral care composition may be based on the desired pH of the final oral care composition and / or product. For example, the total amount of the pH adjuster may range from about 0.05 to about 20 wt.%, based on the total weight of the oral care composition. In some instances, the total amount of pH adjuster is from about 0.05 to about 15 wt.%, about 0.1 to about 10 wt.%, or about 0.12 to about 5 wt.%, including ranges and sub-ranges therebetween, based on the total weight of the oral care composition.

[0084] The oral care compositions may have a pH from about 5.5 to about 9, about 6 to about 8, about 6.5 to about 7.5, about 6 to about 9, about 6 to about 8, or about 6 to about 7, about 7 to about 9, or about 7 to about 8, including any ranges and subranges therebetween.

[0085] In accordance with a further aspect of the invention, provided is a method for manufacturing an oral care composition, such as an oral care composition disclosed herein. The method typically comprises mixing from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil. In some instances, the method may comprise mixing one or more components and / or ingredients in any of the amounts and / or ratios disclosed herein.EXAMPLESExample 1

[0086] A non-limiting, example oral care composition (Ex. A) in the form of a mouthwash was prepared in accordance with aspects of the invention. The formulation of Example Composition A is provided in Table 1.Table 1Example 2

[0087] A non-limiting, example oral care composition (Ex. B) in the form of a mouthwash was prepared in accordance with aspects of the invention. The formulation of Example Composition B is provided in Table 2 (below).Table 2

Claims

CLAIMSWhat Is Claimed Is:

1. A concentrated mouthwash composition comprising: from about 60 to about 85 wt.% of polyol; from about 11 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; and from about 1 to about 10 wt.% of nonionic surfactant, wherein all weight percentages are based on the total weight of the concentrated mouthwash composition.

2. The concentrated mouthwash composition according to claim 1 further comprising a hydrogenated castor oil.

3. The concentrated mouthwash composition according to claim 2, wherein the hydrogenated castor oil comprises a pegylated hydrogenated castor oil.

4. The concentrated mouthwash composition according to any foregoing claim, wherein the polyol comprises glycerin and propylene glycol.

5. The concentrated mouthwash composition according to claim 4, wherein the concentrated mouthwash composition has a weight ratio of propylene glycol to glycerin of about 2: 1 to about 1:3.

6. The concentrated mouthwash composition according to any foregoing claim, wherein the amino acid consists of arginine, lysine, a salt thereof or a combination of two or more thereof.

7. The concentrated mouthwash composition according to any foregoing claim, wherein the amino acid comprises arginine and / or a salt thereof.

8. The concentrated mouthwash composition according to any foregoing claim further comprising a carbonate and / or bicarbonate.

9. The concentrated mouthwash composition according to any foregoing claim, wherein the nonionic surfactant comprises a poloxamer, a sorbitan surfactant, or a combination of two or more thereof.

10. The concentrated mouthwash composition according to claim 9, wherein the nonionic surfactant comprises a sorbitan surfactant selected from ethoxylated sorbitan surfactants.

11. The concentrated mouthwash composition according to any foregoing claim, wherein the concentrated mouthwash composition is essentially free or free of hydrocarbon oils.

12. The concentrated mouthwash composition according to any foregoing claim, wherein the concentrated mouthwash composition is essentially free or free of monoalcohols.

13. The concentrated mouthwash composition according to any foregoing claim, wherein the concentrated mouthwash composition is essentially free or free of anionic surfactants.

14. The concentrated mouthwash composition according to any foregoing claim, wherein the concentrated mouthwash composition is free of surfactants other than nonionic surfactants.

15. The concentrated mouthwash composition according to any foregoing claim further comprising a sweetener in an amount from about 0.1 to about 7 wt.%, wherein the sweetener is selected from sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, perillartine, L- aspartyl-L-phenylalanine methyl ester, saccharine, and a combination of two or more thereof.

16. The concentrated mouthwash composition according to any foregoing claim further comprising a fluoride source in an amount from about 0.1 to about 2 wt.%, wherein the fluoride source is selected from sodium fluoride, potassium fluoride, sodium monofluorophosphate,sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof.

17. An oral care composition comprising: from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; arginine and / or a salt thereof; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil, wherein the oral care composition is a single-phase mouthwash, and all weight percentages are based on the total weight of the oral care composition.

18. A method of manufacturing an oral care composition comprising: mixing from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; an amino acid comprising arginine, lysine, a salt thereof or a combination of two or more thereof; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil.

19. The method according to claim 18 comprising manufacturing an oral care composition according to any one of claims 1 to 20.

20. An oral care composition comprising: from about 50 to about 85 wt.% of polyol; from about 5 to about 30 wt.% of water; from about 1 to about 10 wt.% of nonionic surfactant; and a hydrogenated castor oil, wherein the oral care composition is a single-phase mouthwash, and all weight percentages are based on the total weight of the oral care composition.

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