Composition for preventing hair loss and promoting hair growth containing 3'-hydroxypuerarin

A composition using 3'-hydroxypuerarin and other extracts inhibits key biomarkers to promote hair growth and prevent hair loss, addressing the limitations of existing treatments by enhancing efficacy and safety.

WO2025230263A1PCT designated stage Publication Date: 2025-11-06PHARMACOBIO INC
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Patent Information

Application Number
PCT/KR2025/005737
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-04-29
Filing Date
2025-04-28
Publication Date
2025-11-06

AI Technical Summary

Technical Problem

Current hair loss treatments, such as minoxidil and Propecia, have significant side effects and are not effective in promoting long-term hair growth, while existing therapies for alopecia areata and androgenetic alopecia lack long-term efficacy and have unfavorable side effects.

Method used

A composition containing 3'-hydroxypuerarin, optionally combined with quercitrin and Connarus semidecandrus Jack extract, inhibits 5-α-reductase, androgen receptor, and Janus kinase 1, promoting hair growth by activating the Wnt/β-catenin signaling pathway.

Benefits of technology

The composition effectively prevents hair loss and promotes hair growth by shortening the telogen phase and delaying the transition to the catagen phase, with synergistic effects from ingredient combinations.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present disclosure relates to a composition for preventing hair loss and promoting hair growth. The composition for preventing hair loss or promoting hair growth, of the present disclosure, has the effects of inhibiting the activity of 5-α-reductase, which is a major biomarker of androgenetic alopecia, inhibiting the expression of androgen receptors, and inhibiting the activity of Janus kinase 1, which is a major biomarker of alopecia areata, and exhibits significantly superior effects in preventing hair loss and promoting hair growth by activating the Wnt / beta-catenin signaling pathway. In addition, the composition for preventing hair loss or promoting hair growth, of the present disclosure, can exhibit remarkable synergistic effects in preventing hair loss and promoting hair growth through a combination of two or more specific active ingredients.
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Citation Information

Patent Citations

  • Chinese medicinal composition for treatment of seborrheic alopecia

    CN103212040A

  • Compositions for prevention of hair loss or hairrestoration containing extracts of Pueraria plants

    KR1020080011970A

  • Cosmetic or pharmaceutical composition for promoting hair growth containing Puerarin

    KR1020150085967A

  • Use of an extract of myrothamnus SP for promoting hair growth

    WO2023031730A1

  • KR20230095779A