Systems and methods for bioprocessing
WO2025233627A3PCT designated stage Publication Date: 2026-07-02MICROFLUIDX LTD
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- MICROFLUIDX LTD
- Filing Date
- 2025-05-09
- Publication Date
- 2026-07-02
AI Technical Summary
Technical Problem
Existing cell culture methods struggle to efficiently control the introduction and removal of media in bioreactors without losing a significant number of cells, leading to issues such as cell dilution, starvation, or infection during media exchange.
Method used
A bioreactor system with a tilting mechanism and output channel configuration that allows for controlled media exchange by elevating one end relative to the other, ensuring cells settle at one end while media is removed from the opposite end, minimizing cell loss.
Benefits of technology
The system effectively maintains optimal cell growth conditions by preserving a majority of cells and controlling media volume, reducing the risk of cell loss and contamination during media exchange.
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Smart Images
Figure GB2025050998_02072026_PF_FP_ABST
Abstract
The present disclosure provides systems and methods for bioprocessing. The systems and methods can be implemented using a bioreactor and a tilting device configured to modify an angle between a horizontal plane and a bottom surface of the bioreactor to facilitate removal of media in a bioreactor without losing a significant number of cells in the process.
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