Organ chamber, organ transporter, and organ transportation method

Abstract

The present application discloses an organ chamber, an organ transporter, and an organ transportation method. The organ chamber of the present application comprises a housing, a bearing member, a mounting member, and a support member; an accommodating cavity is defined in the housing; the bearing member is provided in the accommodating cavity, and a clearance hole is formed in the bearing member; the mounting member is provided in the accommodating cavity, and is used for arrangement of lifting portions; the lifting portions are configured to be connected to ligaments of an organ and the mounting member, so as to suspend the organ in the accommodating cavity; the support member passes through the clearance hole and protrudes out of the bearing member; and the support member is configured to be capable of passing through the inferior vena cava of the organ to restrict the oscillation of the organ. The organ chamber is used for accommodating an organ, and can simulate the posture of an organ in a human body to avoid compression of the bottom area of the organ due to its own weight, thereby reducing the probability of local ischemia of the organ.

Description

Organ container, organ transport machine and organ transport method TECHNICAL FIELD

[0001] The present application relates to the field of organ transplantation, and in particular to an organ container, an organ transport machine and an organ transport method. BACKGROUND

[0002] Organ transplantation technology replaces the organs lost due to diseases or injuries by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation is expanding, and the technology is becoming increasingly mature.

[0003] In the prior art, an ex vivo organ is laid flat in an organ container. The bottom area of the ex vivo organ in contact with the organ container is pressed by the weight of the ex vivo organ itself, and the perfused blood is difficult to pass through the bottom area which is pressed more severely, resulting in local ischemia of the bottom of the organ and damage, which seriously affects the success rate of organ transplantation. SUMMARY

[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides an organ container which can simulate the posture of an organ in the human body to avoid the self-weight of the organ pressing the bottom area thereof, thereby reducing the probability of local ischemia of the organ.

[0005] The present application also provides an organ transport machine having the above organ container.

[0006] The organ container according to the first aspect of the present application comprises:

[0007] a box body defining a receiving cavity;

[0008] a carrier provided in the receiving cavity, the carrier being provided with a relief hole;

[0009] a mounting member provided in the receiving cavity, the mounting member being configured to provide a lifting portion for connecting the ligament of the organ and the mounting member to suspend the organ in the receiving cavity;

[0010] a support member penetrating the relief hole and protruding from the carrier;

[0011] The support member is configured to penetrate the inferior vena cava of the organ to limit the shaking of the organ.

[0012] The organ container according to the present application has at least the following beneficial effects:

[0013] The application simulates the posture of the organ in the human body through the cooperation of the bearing, the mounting and the support, and sets the ex vivo organ in a suspended state to reduce the pressure on the bottom of the ex vivo organ, facilitate mechanical perfusion of the ex vivo organ and maintain the activity of the ex vivo organ outside the human body. The support limits the ex vivo organ to reduce damage caused by shaking of the organ during transportation, thereby improving the success rate of organ transplantation.

[0014] According to some embodiments of the application, the organ container further comprises a first pipeline, the box comprises a first through hole in communication with the accommodating cavity, and the first pipeline is arranged in the first through hole and has a first end for connecting with the organ;

[0015] The first pipeline is movably connected with the hole wall of the first through hole, and is configured to be driven to move relative to the box to pull the first end out of the box and to move relative to the box to retract the first end into the box.

[0016] According to some embodiments of the application, the hole wall of the first through hole is provided with a plurality of flanges arranged along the axial direction of the first through hole, and each flange extends along the circumferential direction of the first through hole, and the flanges are used to abut against the first pipeline.

[0017] According to some embodiments of the application, the organ is a liver, the bearing is provided in a shape conforming to the shape of the liver, and the bearing is further provided with a liquid leakage hole arranged at the lowest point of the bearing.

[0018] According to some embodiments of the application, the support has a drainage cavity extending along the axial direction thereof, the tube wall of the support is provided with a drainage hole in communication with the drainage cavity, and the organ container further comprises a second pipeline in communication with the drainage cavity.

[0019] According to some embodiments of the application, the organ container further comprises a mounting seat connected with the box, the support is detachably connected with the mounting seat, and the second pipeline is in communication with the mounting seat, and when the support is connected with the mounting seat, the second pipeline is in communication with the drainage cavity.

[0020] According to some embodiments of the application, the mounting is detachably connected with the box, and when the organ is placed in the accommodating cavity, the mounting can be arranged above the organ.

[0021] The mounting comprises a metal mesh, and the metal mesh is used to arrange the lifting part.

[0022] According to the second aspect of the embodiments of the application, the organ transportation machine comprises:

[0023] a body defining a functional cavity;

[0024] the organ container as in any one of the preceding embodiments, disposed in the functional cavity;

[0025] a perfusion assembly connected to the organ container for blood perfusion of the organ.

[0026] An organ transfer method according to a third aspect of the present application, applied to the organ transfer machine of the preceding embodiments, comprises the following steps:

[0027] S100, cutting off the connection blood vessels of the organ and the donor;

[0028] S200, pulling out the first pipeline of the organ transfer machine, and connecting the first pipeline to the blood vessels of the organ correspondingly, so as to perform blood perfusion through the organ transfer machine;

[0029] S300, transferring the organ from the donor to the organ transfer machine, and suspending the organ in the accommodating cavity of the organ container.

[0030] According to some embodiments of the present application, between step S200 and step S300, the following step is further included:

[0031] S250, threading the support through the inferior vena cava of the organ;

[0032] In step S300, the following step is further included:

[0033] S310, retracting the first pipeline, and placing the organ on the bearing;

[0034] S320, connecting the support to the box;

[0035] S330, covering the organ with the mounting, and connecting the lifting part to the ligament of the organ;

[0036] S340, closing the box, so that the accommodating cavity is in a sealed state.

[0037] Additional aspects and advantages of the present application will be in part apparent and in part pointed out hereinafter. BRIEF DESCRIPTION OF DRAWINGS

[0038] The present application will be further described below in conjunction with the accompanying drawings and embodiments, wherein:

[0039] FIG. 1 is a structural schematic view of an organ container according to an embodiment of the present application;

[0040] Fig. 2 is an exploded schematic view of an organ container according to an embodiment of the present application;

[0041] Fig. 3 is a sectional schematic view of an organ container according to an embodiment of the present application;

[0042] Fig. 4 is an enlarged schematic view of area A in Fig. 3;

[0043] Fig. 5 is a schematic view of a liver suspended in an organ container according to an embodiment of the present application;

[0044] Fig. 6 is a schematic view of a first pipeline being pulled out and connected to a liver according to an embodiment of the present application;

[0045] Fig. 7 is a schematic view of the structure of an organ transport machine according to an embodiment of the present application;

[0046] Fig. 8 is an enlarged schematic view of area B in Fig. 7;

[0047] Fig. 9 is an enlarged schematic view of area C in Fig. 7.

[0048] Reference signs: main body 100; functional cavity 110; second temperature sensor 111; organ container 200; box body 210; accommodating cavity 211; first through hole 212; flange 213; bottom container 214; container cover 215; bearing member 220; avoiding hole 221; liquid leakage hole 222; mounting member 230; pulling part 231; support member 240; drainage cavity 241; drainage hole 242; first pipeline 250; arterial blood supply pipe 251; first flow sensor 2511; first pressure sensor 2512; portal vein blood supply pipe 252; second flow sensor 2521; second pressure sensor 2522; second pipeline 260; mounting seat 270; sealing ring 280; connecting member 290; liquid discharge pipe 295; blood filter 320; blood pump 330; first branch pipe 331; second branch pipe 332; first electric valve 3321; blood oxygen mixing module 340; third branch pipe 341; second electric valve 3411; fourth branch pipe 342; first temperature sensor 343; heating module 350; oxygen production module 360; first channel 361; second channel 362; switching valve 363; liver 400; controller 500; display 550. DETAILED DESCRIPTION

[0049] Embodiments of the present application are described in detail below with reference to the accompanying drawings, in which the same or similar components have the same or similar reference numbers throughout the drawings and a detailed description of the embodiments is given below by way of example only with reference to the accompanying drawings, in which the embodiments of the present application are illustrated, and the embodiments described below are merely illustrative of the present application and should not be construed as limiting the present application.

[0050] In the description of the present application, it needs to be understood that the orientation description, such as the orientation or position relationship indicated by the upper, lower, front, rear, left, right and the like, is based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0051] In the description of the present application, if the meaning of several is more than one, the meaning of multiple is more than two, greater than, less than, more than and the like are understood as not including the number, above, below, within and the like are understood as including the number. If it is described as first, second, it is only for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features or the sequence of indicated technical features.

[0052] In the description of the present application, unless otherwise explicitly limited, the words such as setting, installing, connecting and the like should be broadly understood, and the person skilled in the art can reasonably determine the specific meaning of the above words in the present application in combination with the specific content of the technical solution.

[0053] In the description of the present application, the description of the reference terms "one embodiment", "some embodiments", "illustrative embodiment", "example", "specific example" or "some examples" means that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present application. In the specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0054] Organ transplantation technology replaces the organs lost due to disease or injury by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation is expanding, and the technology is becoming more mature.

[0055] In the prior art, the ex vivo organ is spread in the organ container, wherein the bottom area of the ex vivo organ in contact with the organ container is pressed by the gravity of the ex vivo organ itself, and the perfused blood is difficult to pass through the bottom area which is pressed more seriously, resulting in local ischemia at the bottom of the organ and damage, which seriously affects the success rate of organ transplantation.

[0056] To solve the above problems, the organ container 200 is used to accommodate the organ in the organ transplant process, and the organ container 200 is protected and preserved. The organ container 200 includes a box body 210, a bearing 220, a mounting piece 230 and a support 240, as shown in FIGS. 1-3, the box body 210 includes a bottom container 214 and a container cover 215, the bottom container 214 and the container cover 215 are made of polycarbonate material, polycarbonate is also called PC plastic, which has good structural strength and heat preservation performance, and the density is smaller, which can reduce the weight of the organ container 200.

[0057] The bottom container 214 and the container cover 215 are provided with buckles, and the bottom container 214 and the container cover 215 are detachably connected through the buckles. After the bottom container 214 and the container cover 215 are connected, a closed accommodation cavity 211 for preserving the organ is formed in the box body 210, thereby achieving the effect of bacterial resistance and heat preservation. The buckle can be made of ABS (acrylonitrile / butadiene / styrene copolymer) material, or can be made of metal material such as stainless steel.

[0058] As shown in FIG. 2, to improve the sealing performance between the bottom container 214 and the container cover 215, a sealing ring 280 is arranged between the bottom container 214 and the container cover 215, the sealing ring 280 is made of flexible material such as silicon material, which can be elastically deformed when the bottom container 214 and the container cover 215 are connected by the buckle, thereby reducing the probability of air and liquid leakage at the connection between the bottom container 214 and the container cover 215.

[0059] The bearing 220 and the mounting piece 230 are arranged in the accommodation cavity 211. It should be noted that in the present application, the ex vivo organ is supported and fixed in the accommodation cavity 211 by the cooperation of the bearing 220, the mounting piece 230 and the support 240, and the posture of the organ in the human body is simulated to avoid the weight of the organ pressing the bottom area of the organ, thereby reducing the probability of local ischemia of the organ.

[0060] Specifically, taking the liver 400 as an example, the liver 400 is often connected with the diaphragm and the abdominal wall through the ligamentum teres hepatis, the ligamentum falciforme, the ligamentum coronarium and the left and right triangular ligaments in the human body, and these ligaments provide main support and fixation for the liver 400. Therefore, as shown in FIG. 5, in the present application, when the organ is placed on the bearing 220, the mounting piece 230 is arranged above the organ, and the mounting piece 230 can be provided with a lifting part 231, one end of the lifting part 231 is used to connect the ligament of the ex vivo organ, and the other end is connected with the mounting piece 230, so that the organ is suspended in the accommodation cavity 211, the posture of the organ in the abdominal cavity of the human body is simulated, and the pressure on the ex vivo organ is reduced. It should be noted that the lifting part 231 can be a surgical suture or the like, which is convenient to obtain in the surgical environment.

[0061] It should be noted that the upper end of the organ is connected with the mounting piece 230 through the lifting part 231, and the lower end of the organ is in abutment with the bearing piece 220, and the bearing piece 220 can play a certain supporting role on the organ to reduce the local stress of the ligament area of the organ and balance the stress of the upper and lower ends of the organ. It can be understood that, compared with the prior art in which the organ is flatly placed on the bearing piece 220, the mounting piece 230 and the lifting part 231 are arranged to overcome part of the weight of the organ, thereby reducing the pressure of the organ on the bearing piece 220, and correspondingly reducing the pressure of the bearing piece 220 on the organ.

[0062] The bearing piece 220 is made of medical-grade PU foam material. The surface of the bearing piece 220 formed by this material is relatively smooth, which can reduce friction with the organ and avoid damage to the organ. Moreover, this material has a certain buffering and shock-absorbing effect to reduce the impact of bumps during transportation on the organ. The bearing piece 220 is fixed with the box body 210 by any connection mode such as screw connection or clamping.

[0063] To avoid the organ suspended in the accommodation cavity 211 from shaking during transportation and causing damage due to collision with the cavity wall of the accommodation cavity 211, the support piece 240 is arranged to limit the displacement of the organ. Specifically, as shown in FIGS. 1-5, the bearing piece 220 is provided with an avoiding hole 221, and the support piece 240 can be arranged in the avoiding hole 221, thereby protruding from the bearing piece 220. The lower end of the support piece 240 is connected with the mounting seat 270 arranged on the box body 210, so that the relative positions of the support piece 240 and the bearing piece 220 are fixed. It should be noted that the support piece 240 can be arranged in the inferior vena cava of the organ, so that the support piece 240 can limit the shaking of the organ.

[0064] It should be explained that the inferior vena cava is the largest venous trunk in the human body, mainly responsible for collecting venous blood from the lower body back into the heart. Taking the liver 400 as an example, the inferior vena cava passes through the hepatic venous groove of the liver 400 during upward movement, and here it merges with the hepatic vein to form the second hepatic portal. The hepatic vein is a venous vessel of the liver 400, which drains the blood in the liver 400 back to the inferior vena cava, thereby completing the blood circulation of the liver 400. The inferior vena cava has a relatively large inner diameter and can be used to accommodate the arrangement of the support piece 240. As shown in FIG. 5, the inferior vena cava extends in the vertical direction, and after the support piece 240 is arranged in the inferior vena cava, it can be in abutment with the blood vessel wall of the inferior vena cava, thereby reducing the lateral shaking of the organ during transportation, avoiding the friction between the organ and the wall of the organ storage 200 or the friction between the organ and the bearing piece, and maximizing the prevention of organ damage.

[0065] Based on the above, the application simulates the posture of the organ in the human body through the cooperation of the bearing member 220, the mounting member 230 and the supporting member 240, and sets the ex vivo organ in a suspended state to reduce the compression on the bottom of the ex vivo organ, so as to facilitate the mechanical perfusion of the ex vivo organ and maintain the activity of the ex vivo organ outside the human body. The supporting member 240 plays a limiting role on the ex vivo organ to reduce the damage caused by the shaking of the organ during transportation, thereby improving the success rate of organ transplantation.

[0066] In some embodiments, the organ container 200 further comprises a first pipeline 250, and the wall surface of the box body 210 is provided with a first through hole 212 in communication with the accommodation cavity 211. The first pipeline 250 is inserted into the accommodation cavity 211 through the first through hole 212 and can be connected with the organ. For the convenience of subsequent description, the end of the first pipeline 250 used for connecting with the organ is named as the first end, and the other end is named as the second end, wherein the second end is located outside the accommodation cavity 211 and is usually used for connecting with the perfusion mechanism of the organ transportation machine, so as to realize the mechanical perfusion of the ex vivo organ.

[0067] It can be understood that the first pipeline 250 can be one pipeline or a plurality of pipelines respectively connected with different blood vessels of the organ. The first pipeline 250 at least includes a blood supply pipeline for supplying blood to the organ, and can further include a blood discharge pipeline for discharging blood from the organ, a liquid supply pipeline, a liquid discharge pipeline and the like. For example, as shown in FIGS. 5 and 6, the first pipeline 250 includes a portal vein blood supply pipeline 252 and an arterial blood supply pipeline 251, the portal vein blood supply pipeline 252 is used for connecting with the portal vein blood vessel of the liver 400, and the arterial blood supply pipeline 251 is used for connecting with the arterial blood vessel of the liver 400. The other ends of the two blood supply pipelines are connected with a blood pump or other blood supply mechanism, so that the blood supply can be maintained in the ex vivo state of the organ to maintain the activity of the organ. As shown in FIG. 4, two first through holes 212 are provided on the corresponding box body 210, and the two blood supply pipelines are respectively inserted into the corresponding first through holes 212.

[0068] It should be noted that the first pipeline 250 is movably connected with the box body 210, that is, the first pipeline 250 is movably connected with the hole wall of the first through hole 212. Therefore, the first pipeline 250 can be pulled out or retracted relative to the box body 210. In the existing organ transplantation surgery, after the medical staff completely cuts off and separates the blood vessels of the organ from the blood vessels of the donor, the organ is in an ischemic state. In order to avoid the damage caused by long-term ischemia of the organ, the organ needs to be stored at low temperature.

[0069] In the present application, the first pipeline 250 can be pulled out or retracted relative to the box 210. Therefore, during the operation, the organ container 200 and the matching organ transfer machine can be placed near the operating table, and the first pipeline 250 can be pulled out to the vicinity of the donor operation area. After the blood vessels of the organ are cut off from the blood vessels of the donor, the first pipeline 250 is connected to the corresponding organ blood vessels in time, so as to greatly shorten the ischemic time of the organ. Therefore, it is not necessary to inhibit the activity of the organ by low-temperature preservation, and the state of the organ can be maintained by mechanical perfusion. Further, in the case that the organ has multiple blood vessels connected to the donor, the function of each cut blood vessel can be replaced by the first pipeline 250, thereby reducing the damage to the organ caused by the long operation time of separating the organ from the donor.

[0070] In some further embodiments, in order to make the first pipeline 250 stretchable while ensuring the sealing performance between the first pipeline 250 and the hole wall of the first through hole 212, as shown in FIG. 4, the hole wall of the first through hole 212 is provided with a plurality of flanges 213 which are spaced along the axial direction of the first through hole 212. Each flange 213 extends along the circumferential direction of the first through hole 212, and the flange 213 is used to abut against the first pipeline 250. It can be understood that the provision of the flange 213 not only ensures the sealing performance between the first pipeline 250 and the first through hole 212, but also reduces the contact area between the first pipeline 250 and the hole wall of the first through hole 212, thereby reducing the frictional resistance between the first pipeline 250 and the box 210, so as to facilitate the pulling out or retraction of the first pipeline 250. It should be explained that in some embodiments, the flange 213 can be integrally injection molded with the box 210. In other embodiments, as shown in FIG. 4, the box 210 includes a connecting piece 290 which is separately manufactured from the main body structure of the box 210 and is connected to the main body structure of the box 210 as a whole structure by clamping, bonding or the like. The first through hole 212 is arranged on the connecting piece 290.

[0071] In some embodiments, the carrier 220 is configured as a contoured structure that is adapted to the shape of the liver 400, which is wedge-shaped as shown in FIG. 5, and the width of the liver 400 gradually increases along the direction from left to right in the figure. Accordingly, the carrier 220 gradually decreases in height along the direction from left to right, thereby defining an inclined surface as shown in FIG. 5, which can abut against the liver 400 to increase the contact area between the carrier 220 and the liver 400, thereby dispersing the pressure of the carrier 220 acting on the liver 400, so as to reduce the ischemia caused by excessive local pressure. Further, as shown in FIG. 1, a liquid leakage hole 222 is provided at the lowest point of the carrier 220, which is used to discharge the permeate, blood, and the like discharged from the liver 400 to the organ chamber 200. In some embodiments, as shown in FIG. 7, the liquid leakage hole 222 can also be connected to a liquid discharge pipe 295 to recycle the permeate, blood, and the like to the blood filter 320 for filtration and then recycling.

[0072] In some embodiments, as shown in FIG. 3, the support 240 has a drainage cavity 241 extending along the axial direction thereof, and the tube wall of the support 240 is provided with drainage holes 242 in communication with the drainage cavity 241, so that when the support 240 is inserted into the inferior vena cava, the blood in the inferior vena cava can still be discharged through the support 240, and the blood vessel will not be blocked due to the insertion of the support 240. In addition, as shown in FIG. 5, the organ chamber 200 further comprises a second pipeline 260, one end of which is used to communicate with the drainage cavity 241, and the other end can communicate with the blood filter 320, the blood pump 330, and the like, so as to collect the blood discharged from the inferior vena cava and filter it, and then deliver it to the blood supply vessel through the blood pump 330, so as to complete the blood circulation of the isolated organ. In the embodiment shown in FIG. 7, the blood in the second pipeline 260 is filtered by the blood filter 320, pumped by the blood pump 330, and then delivered back to the organ through the portal vein blood supply vessel 252 and the arterial blood supply vessel 251 after the blood oxygen saturation is increased by the blood oxygen mixing module 340.

[0073] Further, as shown in FIG. 4 and FIG. 5, the organ container 200 further comprises a mounting base 270 connected with the box 210, and the support 240 is detachably connected with the mounting base 270. In addition, the second pipeline 260 is in communication with the mounting base 270, and when the support 240 is connected with the mounting base 270, the second pipeline 260 is in communication with the drainage cavity 241. It can be understood that, different from the first pipeline 250, the second pipeline 260 is fixedly connected with the box 210, and the support 240 is more conveniently detachably connected with the second pipeline 260 through the mounting base 270. In the organ transplantation process, after the organ blood vessels are separated from the donor blood vessels, the support 240 is first inserted into the inferior vena cava of the organ, and then the support 240 is docked with the mounting base 270 in the process of placing the organ in the organ container 200, so that the support 240 can support and fix the organ.

[0074] In some embodiments, the mounting member 230 is detachably connected with the box 210, and when the organ is placed in the accommodation cavity 211, the mounting member 230 can be covered above the organ. It should be noted that the mounting member 230 comprises a metal mesh, and the metal mesh is used to set the pulling part 231. The metal mesh is formed by weaving metal wires, and in the embodiment shown in FIG. 1 and FIG. 2, the metal mesh is made of stainless steel wires with a diameter of 1.5 mm to 3 mm, and has a certain elasticity, so as to play a certain buffering and damping effect during the organ transportation. In addition, the support 240 can be arranged in the grid of the metal mesh, and the top end of the support 240 is provided with a fixing groove, and the fixing groove can be used to set a suture, so as to realize the connection between the support 240 and the metal mesh.

[0075] The embodiment of the second aspect of the present application proposes an organ transportation machine, as shown in FIG. 7, which comprises a machine body 100, a perfusion assembly, and the organ container 200 mentioned in the above-mentioned embodiments. The machine body 100 defines a functional cavity 110, and the organ container 200 is arranged in the functional cavity 110. The perfusion assembly comprises a blood filter 320, an oxygen generation module 360, a blood pump 330 and other life support components, which are used to be connected with the first pipeline 250 and the second pipeline 260 of the organ container 200, so as to perform blood perfusion on the organ, and ensure that various parameters such as blood oxygen, temperature, and nutrient substances in the blood circulation process are maintained within a set range, so as to keep the ex vivo organ active in vitro.

[0076] The blood filter 320 has the function of storing blood and filtering thrombus and organ shedding fragments in the blood. The blood pump 330 extracts the blood in the blood filter 320 to pump out the blood in the manner of heart beating. The second pipeline 260 is in communication with the blood filter 320, and the arterial blood supply vessel 251 and the portal vein blood supply vessel 252 are in communication with the blood pump 330, so that the blood discharged from the inferior vena cava is filtered by the blood filter 320 and then driven by the blood pump 330 to be transported back to the isolated organ in the organ chamber 200.

[0077] Further, as shown in FIGS. 7 to 9, the perfusion assembly further comprises a blood oxygen mixing module 340, and the outlet pipe of the blood pump 330 branches into a first branch pipe 331 and a second branch pipe 332. It can be understood that the first branch pipe 331 and the second branch pipe 332 transport the blood discharged from the inferior vena cava, and the blood oxygen saturation of the blood is low. For the convenience of description, the blood that has not passed through the blood oxygen mixing module 340 is named as non-oxygenated blood, and the blood that has passed through the blood oxygen mixing module 340 is named as oxygenated blood. It can be understood that the blood oxygen saturation of the non-oxygenated blood is lower than that of the oxygenated blood, and thus the first branch pipe 331 and the second branch pipe 332 are both used to circulate the non-oxygenated blood. The first branch pipe 331 is in communication with the blood oxygen mixing module 340 to convert the non-oxygenated blood into the oxygenated blood. The outlet pipe of the blood oxygen mixing module 340 branches into a third branch pipe 341 and a fourth branch pipe 342. It can be understood that the third branch pipe 341 and the fourth branch pipe 342 circulate the oxygenated blood.

[0078] It should be noted that the second branch pipe 332 and the third branch pipe 341 are both in communication with the portal vein blood supply vessel 252 to mix part of the non-oxygenated blood and part of the oxygenated blood and then input the mixed blood into the portal vein through the portal vein blood supply vessel 252. The fourth branch pipe 342 is in communication with the portal vein blood supply vessel 252 to input the oxygenated blood into the organ artery. This design realizes the blood supply to the blood supply vessels with different blood oxygen saturation requirements through one blood oxygen mixing module 340, and thus the perfusion assembly further comprises an oxygen generating module 360 and a heating module 350 matched with the blood oxygen mixing module 340. Therefore, the oxygen generating module 360 and the heating module 350 also only need to be provided one, which reduces the number of parts of the organ transfer machine, is beneficial to reducing the size of the organ transfer machine, and reduces the manufacturing cost of the organ transfer machine. It should be explained that the oxygen generating module 360 is used to supply oxygen to the blood oxygen mixing module 340, and the oxygen generating module 360 can change the working state according to the set value to provide clean gas with different oxygen concentrations and flow rates. The heating module 350 is used to supply heat to the blood oxygen mixing module 340 to maintain the temperature of the oxygenated blood.

[0079] Further, the second branch pipe 332 is provided with a first electric valve 3321, and the third branch pipe 341 is provided with a second electric valve 3411. The organ transport machine further comprises a controller 500, which can control the opening degrees of the first electric valve 3321 and the second electric valve 3411 respectively, so as to adjust the proportion of oxygenated blood and non-oxygenated blood in the portal vein blood supply pipe 252, and thus adjust the blood oxygen saturation of the blood supplied to the portal vein blood supply pipe. It should be explained that the opening degree of the valve generally refers to the degree of opening or closing of the valve. The greater the opening degree, the greater the flow through the valve, and the smaller the opening degree, the smaller the flow through the valve.

[0080] It should be explained that, in addition to being able to adjust the blood oxygen saturation in the portal vein blood supply pipe 252, the first electric valve 3321 and the second electric valve 3411 can also be used to control the pressure and flow of the artery. Specifically, when the opening degrees of the first electric valve 3321 and the second electric valve 3411 decrease, the blood flow through the first electric valve 3321 and the second electric valve 3411 becomes smaller, so that the perfusion flow and perfusion pressure in the portal vein decrease. In the case that the rotation speed of the blood pump 330 is constant, i.e., the total perfusion flow is constant, the perfusion flow and perfusion pressure in the artery increase. Conversely, if the opening degrees of the first electric valve 3321 and the second electric valve 3411 increase, the perfusion flow and perfusion pressure in the artery decrease.

[0081] In the embodiment shown in FIG. 7, the arterial blood supply pipe 251 is provided with a first pressure sensor 2512 and a first flow sensor 2511, and the portal vein blood supply pipe 252 is provided with a second pressure sensor 2522 and a second flow sensor 2521. The controller 500 can be communicatively connected with the first pressure sensor 2512, the first flow sensor 2511, the second pressure sensor 2522 and the second flow sensor 2521 respectively, so as to detect the blood pressure and blood flow in the portal vein and the artery in real time, so that the controller 500 can timely control.

[0082] In some embodiments, as shown in FIGS. 7 to 9, the organ transport machine of the present application also has two temperature control stages of heating and heat preservation. In the heating stage, the heating module 350 is used to heat the blood oxygen mixing module 340, and the temperature of the heat exchange water in the blood oxygen mixing module 340 is detected by the first temperature sensor 343 to prevent the temperature of the heat exchange water from being too high to damage the blood cells. The blood temperature of the outlet pipe of the blood oxygen mixing module 340 is detected by the first temperature sensor 343, and this measurement value is the perfusion temperature. The heating efficiency of the heating module 350 is controlled by using a PID algorithm (a PID control algorithm is a control algorithm combining proportional, integral and differential three links), so that the temperature fed back by the first temperature sensor 343 is within the first temperature range. After the perfusion temperature reaches the set range, the heat preservation stage is entered.

[0083] In the heat preservation stage, since the oxygen production module 360 uses a molecular sieve oxygen production, the heat generated in the oxygen production process can be introduced into the functional cavity 110 through the heat dissipation air duct to heat the gas in the functional cavity 110, and the waste heat generated by the oxygen production module 360 is used to heat the functional cavity 110, so that each liquid outlet pipe and liquid supply pipe of the perfusion assembly is in the set perfusion temperature range.

[0084] Specifically, as shown in FIG. 9, the oxygen production module 360 includes a first channel 361 in communication with the functional cavity 110, a second channel 362 in communication with the external environment, and a switching valve 363 arranged at the intersection of the first channel 361 and the second channel 362. It should be explained that the first channel 361 and the second channel 362 are both connected to the heat dissipation pipeline of the oxygen production module 360 for leading out the heat generated by the oxygen production module 360. The switching valve 363 is used to control the opening degree of the first channel 361 and the second channel 362, so that the temperature in the functional cavity 110 is also maintained within the first temperature range.

[0085] It can be understood that the opening degrees of the first channel 361 and the second channel 362 are negatively correlated, that is, when the opening degree of the first channel 361 increases, the hot air flow introduced into the functional cavity 110 increases, and the opening degree of the second channel 362 decreases, and the heat dissipated into the surrounding environment decreases, and vice versa. The switching of the two heat dissipation channels is realized by one switching valve 363, which simplifies the number of electric control components and saves the cost. Moreover, the waste heat generated by the oxygen production module 360 is used for heat preservation, which improves the energy utilization efficiency and reduces the power consumption of the organ transport machine.

[0086] A second temperature sensor 111 is also arranged in the functional cavity 110 for measuring the gas temperature in the functional cavity 110. After the gas temperature in the functional cavity 110 reaches the set perfusion temperature, the hot air flow into the functional cavity 110 is controlled by the switching valve 363, so that the gas temperature of the switching valve 363 is maintained within the set perfusion temperature range.

[0087] In addition, as shown in FIG. 7, the organ transport machine further includes a display 550, which is in communication connection with the controller 500 and is used to display various parameters in the organ transport machine, including but not limited to perfusion flow, perfusion pressure, perfusion temperature, rotation speed of the blood pump 330, etc.

[0088] The third aspect embodiment of the present application proposes an organ transport method applied to the organ transport machine of the above-mentioned embodiments of the present application, and the organ transport machine includes the following steps:

[0089] S100, cutting the connection blood vessels of the organ and the donor;

[0090] S200, pull out the first pipeline 250 of the organ container 200, and connect the first pipeline 250 with the blood vessels of the organ to perform blood perfusion by the organ transfer machine;

[0091] S300, transfer the organ from the donor to the organ transfer machine, and suspend the organ in the accommodating cavity 211 of the organ container 200.

[0092] Based on the above, the first pipeline 250 of the organ transfer machine can be pulled out, so that after the blood vessels of the organ are separated from the blood vessels of the donor, the first pipeline 250 can be quickly connected with the blood vessels of the organ to replace the blood vessels of the donor and realize the blood supply function of the organ, thereby greatly shortening the ischemia time of the organ and reducing the damage to the organ.

[0093] Further, between the step S200 and the step S300, the following step is further included:

[0094] S250, pass the support 240 through the inferior vena cava of the organ;

[0095] The step S300 includes the following steps:

[0096] S310, retract the first pipeline 250, and place the organ on the carrier 220;

[0097] S320, connect the support 240 with the box body 210;

[0098] S330, cover the organ with the mounting member 230, and connect the lifting part 231 with the ligament of the organ;

[0099] S340, close the box body 210 to make the accommodating cavity 211 in a sealed state.

[0100] The embodiments of the present application are described in detail above in combination with the drawings, but the present application is not limited to the above embodiments, and various changes can be made within the knowledge range of ordinary skilled in the art without departing from the purpose of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. An organ pod for housing an organ, characterized by, The organ container comprises: a box body defining a containing cavity; a carrier arranged in the containing cavity, the carrier being provided with an avoiding hole; a mounting member arranged in the containing cavity, the mounting member being used for arranging a pulling part for connecting the ligament of the organ and the mounting member to suspend the organ in the containing cavity; a support member penetrating the avoiding hole and protruding from the carrier; wherein the support member is configured to be able to penetrate the inferior vena cava of the organ to limit the shaking of the organ.

2. The organ pod of claim 1, wherein, The organ container further comprises a first pipeline, the box body comprises a first through hole communicating with the containing cavity, and the first pipeline penetrates the first through hole and has a first end for connecting with the organ; wherein the first pipeline is movably connected with the hole wall of the first through hole, and the first pipeline is configured to be driven to move relative to the box body to pull out the first end out of the box body and to move relative to the box body to retract the first end into the box body.

3. The organ pod of claim 2, wherein, The hole wall of the first through hole is provided with a plurality of flanges arranged along the axial direction of the first through hole, each of the flanges extending along the circumferential direction of the first through hole, and the flanges are used for abutting against the first pipeline.

4. The organ pod of claim 1, wherein, The organ is a liver, the carrier is arranged in a shape conforming to the shape of the liver, and the carrier is further provided with a liquid leakage hole arranged at the lowest point of the carrier.

5. The organ pod of claim 1, wherein, The support member has a drainage cavity extending along the axial direction thereof, the tube wall of the support member is provided with a drainage hole communicating with the drainage cavity, and the organ container further comprises a second pipeline for communicating with the drainage cavity.

6. The organ pod of claim 5, wherein, The organ container further comprises a mounting seat connected with the box body, the support member is detachably connected with the mounting seat, and the second pipeline communicates with the mounting seat, when the support member is connected with the mounting seat, the second pipeline communicates with the drainage cavity.

7. The organ pod of claim 1, wherein, The mounting member is detachably connected with the box body, and when the organ is placed in the containing cavity, the mounting member can be arranged above the organ; wherein the mounting member comprises a metal mesh for arranging the pulling part.

8. An organ transport machine characterized by, The organ container comprises: a body main body defining a functional cavity; the organ container according to any one of claims 1 to 7 is arranged in the functional cavity; a perfusion assembly connected with the organ container for blood perfusion of the organ.

9. A method of organ transport, characterized by, The organ transfer method applied to the organ transfer machine of claim 8 comprises the following steps: S100, cutting off the connecting blood vessels of the organ and the donor; S200, pulling out the first pipeline of the organ container and connecting the first pipeline with the blood vessels of the organ in correspondence to perform blood perfusion of the organ by the organ transfer machine; S300, transferring the organ from the donor to the organ transfer machine and suspending the organ in the containing cavity of the organ container.

10. The organ transport method according to claim 9, wherein, The steps S200 and S300 further comprise the following steps: S250, the support is arranged in the inferior vena cava of the organ; The step S300 further comprises the following steps: S310, the first pipeline is withdrawn, and the organ is placed on the carrier; S320, the support is connected with the box; S330, the mounting member is covered on the organ, and the lifting part is connected with the ligament of the organ; S340, the box is closed, so that the accommodation cavity is in a sealed state.

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