Method for reconstructing interdental papilla using hyaluronic acid

Abstract

The present invention relates to a method for reconstructing interdental papillary using hyaluronic acid and, more specifically, to a method comprising a process of injecting hyaluronic acid into the gingiva. The method for reconstructing interdental papilla comprising the above process exhibits the effect of alleviating black triangles or food impaction between teeth by enlarging soft tissue in the interdental papilla loss area and increasing the volume of the interdental papilla.

Description

Method for reconstructing interdental papilla using hyaluronic acid

[0001] The present invention relates to a method for reconstructing an interdental papilla using hyaluronic acid, and more particularly, to a method for reconstructing an interdental papilla using hyaluronic acid, which has the effect of improving the phenomenon of black triangles or food getting stuck between teeth through a reconstructive process such as expansion of soft tissue in a part where the interdental papilla has disappeared and increase in the volume of the interdental papilla.

[0002] The interdental papilla is the part of the free gingiva that occupies the space between two adjacent teeth and allows the free gingival margin to continue in the dental arch in a festoon-like pattern.

[0003] The papillae are not only significant for biology and coating the proximal portion of the tooth, but also have an important aesthetic function, especially in the anterior region. The explicit interest in preserving all interdental tissues for aesthetic purposes began with the 1985 article by Evian and colleagues (Evian CI, Com H, Rosenberg ES. Retained interdental papilla procedure for maintaining anterior esthetics. Compend Contin Educ Dent 1985;6(l):58-64), which described a surgical technique with a specific esthetic purpose and defined it as a "retained interdental papilla procedure".

[0004] The loss of this portion of gingival tissue is a topic of research, particularly with regard to possible preservation and regeneration techniques. Indeed, dental aesthetics is becoming increasingly important to both dentists and patients. Indeed, the presence of the interdental papilla between the maxillary incisors is a crucial aesthetic component. Recession of the interdental papilla not only causes various functional problems but also esthetic issues, such as the formation of the so-called black triangle ("black triangle syndrome" or "recession of the interdental papilla"). In addition to functional difficulties during chewing, such as food retention and insertion in the area of ​​gingival loss, food can easily become lodged between the teeth, causing discomfort.

[0005] In 1998, Nordland and Tarnow classified the loss of papillary height using a scale that is still widely used, dividing it into four grades: normal, grade I, grade II, and grade III (Nordland WP, ​​Tarnow DP. A classification system for loss of papillary height. J Periodontol 1998;69:1124-6).

[0006] The purpose of the present invention is to provide a method for reconstructing an interdental papilla using hyaluronic acid, which has the effect of improving the phenomenon of black triangles or food getting stuck between teeth through a reconstructive process such as expansion of soft tissue in the area where the interdental papilla has disappeared and increase in the volume of the interdental papilla.

[0007] The object of the present invention is achieved by providing a method for reconstructing an interdental papilla using hyaluronic acid, characterized in that it comprises a process of injecting hyaluronic acid into the gums.

[0008] According to a preferred feature of the present invention, the gingiva is a gingival connective tissue layer.

[0009] According to a more preferred feature of the present invention, the hyaluronic acid is injected using a 25 to 35G needle.

[0010] According to a more preferred feature of the present invention, the needle is 30G and is equipped with an auto-injector.

[0011] According to a further preferred feature of the present invention, the hyaluronic acid is injected 3 to 5 times in an amount of 0.001 to 0.003 cc at intervals of 2 to 4 weeks.

[0012] According to a further preferred feature of the present invention, the hyaluronic acid is injected four times in an amount of 0.002 cc at three-week intervals.

[0013] The method for reconstructing an interdental papilla using hyaluronic acid according to the present invention is excellent in improving black triangles and preventing food from getting stuck, etc. through a reconstructive process such as expanding soft tissue in the area where the interdental papilla is lost between teeth and increasing the volume of the interdental papilla.

[0014] Figure 1 is a photograph showing the interdental papilla of subject A before and after undergoing interdental papilla reconstruction surgery through Example 1 of the present invention.

[0015] Figure 2 is a photograph showing the interdental papilla of test subject B before and after undergoing interdental papilla reconstruction surgery through Example 2 of the present invention.

[0016] Figure 3 is a photograph showing the interdental papilla of test subject C before and after undergoing reconstruction of the interdental papilla through Example 3 of the present invention.

[0017] Figure 4 is a photograph showing the interdental papilla of test subject D before and after undergoing reconstruction of the interdental papilla through Example 4 of the present invention.

[0018] Figure 5 is a photograph showing the interdental papilla of test subject E before and after undergoing a reconstruction procedure of the interdental papilla through Example 5 of the present invention.

[0019] Hereinafter, preferred embodiments of the present invention and the properties of each component will be described in detail. However, this is intended to be a detailed description to enable a person having ordinary knowledge in the technical field to which the present invention pertains to easily carry out the invention, and does not mean that the technical idea and scope of the present invention are limited thereby.

[0020]

[0021] The method for reconstructing an interdental papilla using hyaluronic acid according to the present invention comprises a process of injecting hyaluronic acid into a gingival connective tissue layer, and is preferably performed by injecting 0.001 to 0.003 cc of hyaluronic acid into the gingival connective tissue layer 3 to 5 times at 2 to 4 week intervals using a 25 to 35G needle.

[0022]

[0023] The above hyaluronic acid (HA) is a sulfur-containing polymer belonging to the glycosaminoglycan family, which is ubiquitous in mammalian tissues, has an unbranched structure, and is composed of regularly repeating disaccharides composed of glucuronic acid and N-acetylglucosamine.

[0024] Hyaluronic acid (HA) varies greatly in size, exceeding 1 million daltons and reaching 3 to 9 million daltons in some tissues. Isolated from the hyaloid substance of the vitreous body by Mayer in 1934, it was for many years considered a filling and structural substance with special hydrophilic properties, with no specific biological role. However, the recent discovery of tissue receptors for hyaluronic acid, such as CD44 and RHAMM, has focused attention on the biological role of this polymer, leading to an expansion of research into the role of hyaluronic acid as an active agent in more complex processes associated with tissue regeneration and repair.

[0025] In the present invention, hyaluronic acid can be used as is or can be used in various ways by being salted with sodium. The hyaluronic acid increases the volume of the interdental papilla through an immediate soft tissue expansion effect, the functionality of hyaluronic acid, and its action as a collagen stimulator and fibroblast stimulator, resulting in an effect of reducing the black triangle area of ​​the interdental papilla or preventing food from getting stuck in the area.

[0026] Furthermore, to maintain volume in narrow, rigid areas subject to high pressure, such as the gingival connective tissue layer of the interdental papilla, it is desirable to use a highly viscoelastic substance, such as hyaluronic acid. Furthermore, hyaluronic acid is easily degraded by external stimuli applied to the tissue, so it is preferable to use hyaluronic acid with high viscoelasticity to resist physical stimuli.

[0027] If the molecular weight of the hyaluronic acid or its sodium salt is less than 500 kilodaltons, it may cause skin inflammation, and if the molecular weight of the hyaluronic acid or its sodium salt exceeds 3000 kilodaltons, it is not preferable because the molecular weight is too large and it is difficult to properly inject into the gingival connective tissue layer.

[0028] In addition, in the process of injecting the hyaluronic acid or its sodium salt into the gingival connective tissue layer, it is preferable to use a needle of 25 to 35G, and as described above, the needle of 25 to 35G exhibits the effect of effectively reconstructing the interdental papilla tissue by minimally invasively injecting the hyaluronic acid or its sodium salt into the gingival connective tissue layer.

[0029] The injection solution comprising the above hyaluronic acid or its sodium salt has a very high viscosity compared to injection solutions containing other ingredients, so the pressure transmitted from the syringe to the injection needle is very high when the injection solution is injected, so it is preferable to use a needle of 25 to 35 G.

[0030] If the needle is less than 25G, the pressure transmitted from the syringe to the injection needle when injecting the injection solution is lowered, but the injection solution cannot be properly injected into the gingival connective tissue layer, which has a very narrow tissue layer. If the needle exceeds 35G, the pressure transmitted to the injection needle when injecting the injection solution is too high, so the injection solution cannot be properly injected, which is not desirable.

[0031] At this time, it is preferable that the syringe be equipped with an auto-injector. This is because the gingival connective tissue layer of the interdental papilla area is a dense tissue with high resistance during injection, so it is preferable to use an auto-injector to stably inject the injection solution with strong pressure. If the injection solution is injected manually without an auto-injector, the resistance will inevitably cause the hand to tremble, making it difficult to inject an accurate amount of the injection solution.

[0032] In addition, it is preferable to inject the injection solution composed of hyaluronic acid and its sodium salt as described above in an amount of 0.005 to 0.010 cc 3 to 5 times at intervals of 2 to 4 weeks. However, if the weekly injection amount of the injection solution is less than 0.005 cc or the injection period exceeds 4 weeks, the reconstructive effect of the interdental papilla is minimal, and if the injection period of the injection solution is less than 2 weeks, the reconstructive effect of the interdental papilla is not significantly improved, but the cost of the procedure is excessively increased, which is not preferable.

[0033] Additionally, in some cases, if the interdental papilla reconstruction effect is insufficient even after 5 treatments under the above conditions, an additional process of injecting 0.001 to 0.003 cc of the solution per week may be performed.

[0034] In addition, if a black triangle is observed even after 5 treatments under the above conditions, it corresponds to partial interdental papilla reconstruction, and in this case, it is also advisable to move on to the follow-up observation stage, and depending on the progress thereafter, additional injections can be performed to reconstruct the insufficient reconstruction area or the re-formed black triangle.

[0035]

[0036] Hereinafter, a method for reconstructing an interdental papilla using hyaluronic acid according to the present invention and the effect of reconstructing an interdental papilla through the method for reconstructing the interdental papilla will be described with examples.

[0037]

[0038] <Example 1>

[0039] The interdental papilla of subject A, who had a black triangle angle between the 11th and 12th front teeth, was reconstructed by injecting 0.002 cc of hyaluronic acid four times every three weeks using a 30G needle equipped with an autoinjector into the gingival connective tissue layer.

[0040]

[0041] <Example 2>

[0042] The interdental papilla of subject B, who had a black triangle angle between the 11th and 21st front teeth, was reconstructed by injecting 0.002 cc of hyaluronic acid four times every three weeks using a 30G needle equipped with an autoinjector into the gingival connective tissue layer.

[0043]

[0044] <Example 3>

[0045] The interdental papilla of subject C, who had a black triangle angle between the 11th and 21st front teeth, was reconstructed by injecting 0.002 cc of hyaluronic acid four times every three weeks using a 30G needle equipped with an autoinjector into the gingival connective tissue layer.

[0046]

[0047] <Example 4>

[0048] The interdental papilla of subject D, who had a black triangle angle between the 11th and 21st front teeth, was reconstructed by injecting 0.002 cc of hyaluronic acid four times every three weeks using a 30G needle equipped with an autoinjector into the gingival connective tissue layer.

[0049]

[0050] <Example 5>

[0051] The interdental papilla was reconstructed by injecting 0.002 cc of hyaluronic acid four times every three weeks using a 30G needle equipped with an autoinjector into the gingival connective tissue layer of subject E, who had a black triangle angle between the 23rd and 24th canines.

[0052]

[0053] The appearance of the interdental papilla of test subjects A to E, whose interdental papillae were reconstructed through the above examples 1 to 5, before and after the procedure were photographed and are shown in Figures 1 to 5 below.

[0054] As shown in Figures 1 to 5 below, it can be confirmed that part or all of the interdental papilla was reconstructed after the procedure in all test subjects compared to before the procedure.

[0055]

[0056] Therefore, the method for reconstructing an interdental papilla using hyaluronic acid according to the present invention improves the black triangle through a reconstructive process such as expansion of soft tissue in the area where the interdental papilla is lost in the maxillary anterior region and increase in the volume of the interdental papilla.

Claims

1. A method for reconstructing an interdental papilla using hyaluronic acid, characterized by the process of injecting hyaluronic acid into the gums.

2. In claim 1, A method for reconstructing an interdental papilla using hyaluronic acid, characterized in that the above gingiva is a gingival connective tissue layer.

3. In claim 1, A method for reconstructing an interdental papilla using hyaluronic acid, characterized in that the hyaluronic acid is injected using a 25 to 35G needle.

4. In claim 3, A method for reconstructing an interdental papilla using hyaluronic acid, characterized in that the above needle is 30G and an auto-injector is provided.

5. In claim 1 or 3, A method for reconstructing an interdental papilla using hyaluronic acid, characterized in that the hyaluronic acid is injected 3 to 5 times in an amount of 0.001 to 0.003 cc at intervals of 2 to 4 weeks.

6. In claim 5, A method for reconstructing interdental papilla using hyaluronic acid, characterized in that the above hyaluronic acid is injected 4 times in an amount of 0.002 cc at 3-week intervals.

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