Regulatory elements and related methods

Abstract

Provided herein are translational regulatory elements, including 5' and 3' UTRs and nucleic acid molecules (e.g., RNA molecules (e.g., mRNA molecules), DNA molecules) comprising one or more of the same. The disclosure further relates to pharmaceutical compositions comprising the same for the use in the expression of proteins in a subject, e.g., for treating diseases.

Description

Attorney Docket No.: 62801.85 WO01REGULATORY ELEMENTS AND RELATED METHODS RELATED APPLICATIONS

[0001] This application claims priority to U. S. Serial No.: 63 / 721,644, filed November 18, 2024 and U. S. Serial No.: 63 / 790,187, filed April 17, 2025, the entire contents of each of which is incorporated herein by reference.1. FIELD

[0002] This disclosure relates to regulatory elements (e.g., transcriptional and translational regulatory elements), including 5' and 3' UTRs and nucleic acid molecules (e.g., RNA molecules (e.g., mRNA molecules), DNA molecules) comprising one or more of the same. The disclosure further relates to pharmaceutical compositions comprising the same for the use in the expression of proteins in a subject, e.g., for treating diseases.2. BACKGROUND

[0003] Untranslated regions (UTRs) are nucleic acid sequences that can be operably connected to an open reading frame of a nucleic acid molecule (e.g., an RNA molecule, a DNA molecule) but are not themselves translated into protein. UTRs can mediate, e.g., translation regulation, control of RNA stability, cellular localization of RNA, and the rate of protein synthesis. UTRs can contain linear and / or structural regulatory elements within them that can, e.g., mediate binding to various proteins and non-coding RNAs. UTRs can be positioned both upstream (5') of an open reading frame (e.g., 5' UTRs) and / or downstream (3') of an open reading frame (e.g., 3' UTRs).3. SUMMARY

[0004] Provided herein are, inter alia, 5' and 3' UTRs for use e.g., in the expression of one or more protein of interest. Further provided herein are nucleic acid molecules (e.g., RNA molecules (e.g., mRNA molecules), DNA molecules) comprising one or more 5' and / or 3' UTR described herein (or a combination thereof) and an open reading frame encoding a protein of interest (e.g., a therapeutic protein) (and pharmaceutical compositions comprising the same). Further provided herein are methods of utilizing any of the foregoing in e.g., methods of expressing a protein of interest, and methods of treating a disease.

[0005] As such, in one aspect, provided herein are isolated nucleic acid molecules comprisingAttorney Docket No.: 62801.85WO01an engineered 5' untranslated region (5' UTR) comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

[0006] In one aspect, provided herein are isolated nucleic acid molecules comprising, in the following order, an engineered 5' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%. 90%, 91%, 92%. 93%, 94%, 95%. 96%, 97%, 98%. 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and an open reading frame encoding an RNA transcript or protein (e.g., a protein).

[0007] In some embodiments, the engineered 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

[0008] In some embodiments, the engineered 5' UTR comprises a nucleotide sequence at 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

[0009] In some embodiments, the engineered 5' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

[0010] In one aspect, provided herein are isolated nucleic acid molecules comprising an engineered 3' untranslated region (3' UTR) comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%. 94%, 95%, 96%, 97%. 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

[0011] In one aspect, provided herein are isolated nucleic acid molecules comprising, in the following order, an open reading frame encoding an RNA transcript or protein {e.g., a protein); and an engineered 3' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS; 1-1505.

[0012] In some embodiments, the engineered 3' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS; 1-1505.

[0013] In some embodiments, the engineered 3' UTR comprises a nucleotide sequence at 95%, 96%, 97%, 98%. 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.Attorney Docket No.: 62801.85WO01

[0014] In some embodiments, the engineered 3' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

[0015] In one aspect, provided herein are isolated nucleic acid molecules comprising a 5' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%. 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and a 3' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

[0016] In one aspect, provided herein are isolated nucleic acid molecules comprising, in the following order, a 5' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%. 95%, 96%, 97%. 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; an open reading frame encoding an RNA transcript or protein (e.g., a protein); and a 3' UTR comprising a nucleotide sequence at least 85%, 86%. 87%. 88%, 89%, 90%. 91%. 92%, 93%, 94%. 95%. 96%, 97%, 98%. 99%. or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

[0017] In some embodiments, the 5' UTR and the 3' UTR are a pair set forth in Table 6, Table 7 or Table 8.

[0018] In some embodiments, the 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%. 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and the 3' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS; 1-1505.

[0019] In some embodiments, the 5' UTR comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and the 3' UTR comprises a nucleotide sequence at least 95%, 96%. 97%. 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

[0020] In some embodiments, the 5' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and the 3' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

[0021] For the sake of clarity, it should be understood that the following embodiments are applicable to any of the foregoing aspects as if recited directly following each aspect. In someAttorney Docket No.: 62801.85 WO01embodiments, the nucleic acid molecule is an RNA molecule. In some embodiments, the RNA molecule is a translatable polyribonucleotide. In some embodiments, the RNA molecule is an mRNA molecule. In some embodiments, the RNA molecule is a circular RNA molecule.

[0022] In some embodiments, the RNA molecule comprises one or more translation regulatory elements.

[0023] In some embodiments, the RNA molecule (e.g., the open reading frame) comprises a translation initiation element (e.g., a start codon). In some embodiments, the translation initiation element is a start codon (e.g., AUG. CUG, GUG, UUG, ACG, AUC, AUU, AAG, AUA, or AGG).

[0024] In some embodiments, the RNA molecule (e.g., the open reading frame) comprises a translation termination element (e.g., a stop codon). In some embodiments, the translation termination element comprises a stop codon (e.g., UAA, UGA, or UAG).

[0025] In some embodiments, the RNA molecule comprises an internal ribosome entry site (IRES).

[0026] In some embodiments, the RNA molecule comprises a stagger element. In some embodiments, the stagger element comprises a 2A-like sequence.

[0027] In some embodiments, the RNA molecule comprises a 5' cap structure. In some embodiments, the RNA molecule lacks a 5' cap structure.

[0028] In some embodiments, the RNA molecule comprises a poly (A) sequence, a poly(U) sequence, a poly(A)(U) sequence, and / or a poly(A)(C) sequence. In some embodiments, the RNA molecule comprises a 3' poly(A) sequence. In some embodiments, the RNA molecule lacks a 3' poly(A) sequence. In some embodiments, the RNA molecule lacks a 3' poly(A) sequence greater than 10, 15, 20, 25, 50, 100. 150, 200, 250, 300. 350, 400, 450, or 500 nucleotides.

[0029] In some embodiments, the RNA molecule is a circular RNA molecule that lacks a 5' cap structure and lacks 3' poly(A) sequence. In some embodiments, the RNA molecule is a circular RNA molecule that lacks a 5' cap structure and lacks 3' poly (A) sequence greater than 10, 15, 20, 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, or 500 nucleotides. In some embodiments, the RNA molecule is an mRNA molecule comprising a 5'-cap structure and a 3' poly (A) sequence.

[0030] In some embodiments, the nucleotide sequence of the RNA molecule is codon optimized.

[0031] In some embodiments, the nucleic acid molecule is a DNA molecule.

[0032] In some embodiments, the DNA molecule is a transcribable polynucleotide.Attorney Docket No.: 62801.85 WO01

[0033] In some embodiments, the DNA molecule comprises one or more transcriptional regulatory elements.

[0034] In some embodiments, the DNA molecule comprises one or more promoter. In some embodiments, the DNA molecule comprises an enhancer. In some embodiments, the DNA molecule comprises an intron. In some embodiments, the DNA molecule comprises transcription termination sequence. In some embodiments, the DNA molecule comprises a posttranscriptional regulatory element. In some embodiments, the DNA molecule comprises a poly(A) signal sequence. In some embodiments, the DNA molecule comprises an inverted terminal repeat (ITR). In some embodiments, the DNA molecule comprises a 5' ITR and a 3' ITR. In some embodiments, the DNA molecule comprises, in the following order, a 5' ITR, the engineered promoter, the open reading frame, and a 3' ITR.

[0035] In some embodiments, the nucleic acid molecule comprises at least one modified nucleotide. In some embodiments, the nucleic acid molecule comprises at least one modified nucleobase. In some embodiments, the nucleic acid molecule comprises at least one modified sugar moiety. In some embodiments, the nucleic acid molecule comprises at least one modified internucleoside linkage.

[0036] In some embodiments, the nucleic acid molecule comprises a plurality of open reading frames, each encoding an RNA transcript or protein. In some embodiments, each open reading frame of the plurality encodes a protein. In some embodiments, each open reading frame of the plurality encodes a different protein. In some embodiments, each open reading frame of the plurality encodes an RNA transcript. In some embodiments, each open reading frame of the plurality encodes a different RNA transcript.

[0037] In some embodiments, the open reading frame encodes a protein. In some embodiments, the protein is a therapeutic protein. In some embodiments, the protein {e.g., therapeutic protein) is an immunogen {e.g., viral, bacterial, fungal). In some embodiments, the protein {e.g., therapeutic protein) comprises an antibody (or a functional fragment or variant thereof) or a fusion protein. In some embodiments, the protein {e.g., therapeutic protein) is a hormone, enzyme, growth factor, blood protein, a clotting factor, transcription factor, cytokine, chemokine, chimeric antigen receptor, T-cell receptor, or nuclease {e.g., endonuclease).

[0038] In some embodiments, the open reading frame encodes an RNA transcript. In some embodiments, the RNA transcript is a tRNA, miRNA, siRNA, antisense oligonucleotides (ASO),Attorney Docket No.: 62801.85 WO01IncRNA, rRNA, snRNA, microRNA, piRNA, snoRNA, snRNA, exRNA, scaRNA, Y RNA, or hnRNA

[0039] In one aspect, provided herein are vectors comprising a nucleic acid molecule described herein, an RNA molecule described herein, or a DNA molecule described herein. In some embodiments, the vector is a plasmid or a viral vector.

[0040] In one aspect, provided herein are carriers comprising a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, or a vector described herein.

[0041] In some embodiments, the carrier is a lipid nanoparticle (LNP), liposome, lipoplex, or nanoliposome. In some embodiments, the carrier is an LNP. In some embodiments, the LNP comprises a cationic lipid, a neutral lipid, a cholesterol, and / or a PEG lipid. In some embodiments, the LNP comprises a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. In some embodiments, the LNP has a mean particle size of between 80 nm and 160 nm.

[0042] In one aspect, provided herein is a cell (e.g., host cell) or a population of cells (e.g., a population of host cells) comprising a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, or a carrier described herein.

[0043] In one aspect, provided herein are pharmaceutical compositions comprising a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, or a cell or population of cells described herein, and a pharmaceutically acceptable excipient.

[0044] In one aspect, provided herein are vaccine compositions comprising a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, or a cell or population of cells described herein. In some embodiments, the protein (e.g., therapeutic protein) comprises an immunogen.

[0045] In one aspect, provided herein are kits comprising a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, a cell or population of cells described herein, a vaccine composition described herein, or a pharmaceutical composition described herein, and optionally comprising instructions for use of the foregoing.

[0046] In one aspect, provided herein are in vitro methods of making a protein (e.g., aAttorney Docket No.: 62801.85 WO01therapeutic protein), the method comprising (a) culturing a population of cells in vitro; (b) introducing a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, or a carrier described herein, to the population of cells; and (c) culturing the population of cells under conditions and for a period of time sufficient to allow for expression of the protein (e.g., therapeutic protein); and (d) optionally isolating and / or purifying the expressed protein (e.g., therapeutic protein).

[0047] In one aspect, provided herein are methods of delivering an RNA molecule, a DNA molecule, a vector, or a carrier to a cell, the method comprising delivering to the cell a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, a cell or population of cells described herein, a vaccine composition described herein, or a pharmaceutical composition described herein, to thereby deliver the RNA molecule, the DNA molecule, the vector, or the carrier to the cell.

[0048] In some embodiments, the method is in vitro. In some embodiments, the cell is in vitro or ex vivo. In some embodiments, the cell is in a subject.

[0049] In one aspect, provided herein are methods of delivering an RNA molecule, a DNA molecule, a vector, a carrier, a cell, vaccine composition, or pharmaceutical composition to a subject in need thereof, the method comprising administering to the subject a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, a cell or population of cells described herein, a vaccine composition described herein, or a pharmaceutical composition described herein, to thereby deliver the RNA molecule, the DNA molecule, the vector, the carrier, the cell, the vaccine composition, or the pharmaceutical composition to the subject.

[0050] In one aspect, provided herein are methods of expressing a protein (e.g., a therapeutic protein) in a cell, the method comprising delivering to the cell a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, a cell or population of cells described herein, a vaccine composition described herein, or a pharmaceutical composition described herein, to thereby express the protein in the cell.

[0051] In some embodiments, the method is in vitro. In some embodiments, the cell is in vitro or ex vivo. In some embodiments, wherein the cell is in a subject.

[0052] In one aspect, provided herein are methods of expressing a protein (e.g., a therapeuticAttorney Docket No.: 62801.85 WO01protein) in a subject in need thereof, the method comprising administering to the subject a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, a cell or population of cells described herein, a vaccine composition described herein, or a pharmaceutical composition described herein, to thereby express the protein (e.g., therapeutic protein) in the subject.

[0053] In one aspect, provided herein are methods of treating, ameliorating, or preventing a disease in a subject in need thereof, the method comprising administering to the subject a nucleic acid molecule described herein, an RNA molecule described herein, a DNA molecule described herein, a vector described herein, a carrier described herein, a cell or population of cells described herein, a vaccine composition described herein, or a pharmaceutical composition described herein, treat, ameliorate, or prevent the disease in the subject.

[0054] In one aspect, provided herein are methods of treating, ameliorating, or preventing a disease in a subject in need thereof, the method comprising administering to the subject the protein made by a method described herein (or a pharmaceutical composition comprising the same), treat, ameliorate, or prevent the disease in the subject.

[0055] In some embodiments, the disease is a proinflammatory disease (e.g., an autoimmune disease), an immunosuppressive disease, a cancer, a hormone related disease, a growth factor related disease, a blood clotting disease, or a genetic disease.4. BRIEF DESCRIPTION OF THE DRAWINGS

[0056] FIG. 1A is a bar graph showing protein (eGFP) expression from each of constructs 0-8 (relative to construct 7) in AML 12 cells in vitro. FIG. IB is a bar graph showing protein (eGFP) expression from each of constructs 0-8 (relative to construct 7) in Fa2N cells in vitro. FIG. 1C is a bar graph showing protein (eGFP) expression from each of constructs 0-8 (relative to construct 7) in Huh7 cells in vitro. FIG. ID is a bar graph showing protein (eGFP) expression from each of constructs 0-8 (relative to construct 7) in in primary human hepatocytes in vitro. FIG. IE is a bar graph showing protein (eGFP) expression from each of constructs 0-8 (relative to construct 7) in in Hela cells in vitro.5. DETAILED DESCRIPTION

[0057] The inventors have, inter alia, designed novel 5' and 3' UTRs and identified novelAttorney Docket No.: 62801.85WO01combinations of 5' and 3' UTRs to, e.g., effectively express one or more molecule of interest (e.g., one or more protein of interest) (e.g., in vitro or in vivo). Accordingly, the 5' and 3' UTRs described herein (and nucleic acid molecules (e.g., RNA molecules (e.g., mRNA molecules), DNA molecules) comprising one or more of the same) are useful for the production of proteins (e.g., therapeutic proteins); and for the delivery to or expression of proteins (e.g., therapeutic proteins) in a human, e.g., for the treatment of diseases. As such, the current disclosure provides, inter alia, 5' and 3' UTRs and nucleic acid molecules (e.g., RNA molecules (e.g., mRNA molecules), DNA molecules) comprising one or more of the same, and pharmaceutical compositions comprising the same for the use in the expression of proteins (e.g., in vitro or in vivo).TABLE OF CONTENTS5.1 Definitions5.2 5' Untranslated Regions5.3 3' Untranslated Regions5.4 Combinations of 5' and 3' Untranslated Regions5.5 Exemplary Properties of 5' and 3' Untranslated Regions and Nucleic Acid Molecules Comprising the Same5.6 RNA Molecules5.6.1 mRNA Molecules5.6.2 Circular RNA Molecules5.6.3 Codon Optimization5.6.4 Translational Regulatory Elements5.6.4.1 Translation Initiation Elements5.6.4.2 Translation Termination Elements5.6.4.3 Internal Ribosome Entry Sites5.6.4.4 Stagger Elements5.6.4.5 5' Cap Structures5.6.4.6 3' Poly(A) Sequence5.6.4.7 Spacer Sequences5.6.5 RNA Modifications5.6.6 Exemplary RNA Molecules5.7 DNA MoleculesAttorney Docket No.: 62801.85WO01Es)sizable LipidsipidsonentsDiseasesAttorney Docket No.: 62801.85 WO015.1 Definitions

[0058] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

[0059] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which the claimed subject matter belongs. It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of any subject matter claimed.

[0060] In this application, the use of the singular includes the plural unless specifically stated otherwise. For example, as used in the specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Furthermore, use of the term “including” as well as other forms, such as “include,” “includes,” and “included,” is not limiting.

[0061] It is understood that wherever aspects are described herein with the language “comprising,” otherwise analogous aspects described in terms of “consisting of’ and “consisting essentially of’ are also provided.

[0062] The term “and / or” where used herein is to be taken as specific disclosure of each of the two specified features or components with or without the other. Thus, the term “and / or” as used in a phrase such as “A and / or B” herein is intended to include “A and B,” “A or B,” “A” (alone), and “B” (alone). Likewise, the term “and / or” as used in a phrase such as “A, B, and / or C” is intended to encompass each of the following aspects: A, B, and C; A, B, or C: A or C; A or B; B or C; A and C; A and B; B and C; A (alone); B (alone); and C (alone).

[0063] As described herein, any concentration range, percentage range, ratio range or integer range is to be understood to include the value of any integer within the recited range and, when appropriate, fractions thereof (such as one tenth and one hundredth of an integer), unless otherwise indicated.

[0064] The term “about” refers to a value or composition that is within an acceptable error range for the particular value or composition as determined by one of ordinary skill in the art, which will depend in part on how the value or composition is measured or determined, i.e., theAttorney Docket No.: 62801.85 WO01limitations of the measurement system. When particular values or compositions are provided in the application and claims, unless otherwise stated, the meaning of “about” should be assumed to be within an acceptable error range for that particular value or composition.

[0065] Where proteins and / or polypeptides are described herein, it is understood that nucleic acid molecules (e.g., RNA (e.g., mRNA) or DNA nucleic acid molecules) encoding the protein are also provided herein.

[0066] Where proteins, polypeptides, nucleic acid molecules, vectors, carriers, etc. are described herein, it is understood that isolated forms of the proteins, polypeptides, nucleic acid molecules, vectors, carriers, etc. are also provided herein.

[0067] Where proteins, polypeptides, nucleic acid molecules, etc. are described herein, it is understood that recombinant forms of the proteins, polypeptides, nucleic acid molecules, etc. are also provided herein.

[0068] Where proteins or sets of proteins are described herein, it is understood that both proteins comprising the primary structure are provided herein as well as proteins folded into their three-dimensional structure (z.<?., tertiary or quaternary structure) are provided herein.

[0069] Where proteins are described herein, it is understood that functional variants, functional fragment, and functional variants and fragments are provided herein. It is understood that the terms “functional fragment or variant,” “functional fragment or functional variant,” “functional fragment and / or functional variant” and the like - provide specific disclosure of proteins that are functional fragments, functional variants, and functional fragments and functional variants (of the reference protein).

[0070] As used herein, the term “5' untranslated region” or “5' UTR” refers to an untranslated nucleic acid molecule when within the context of a translatable RNA molecule or a transcribable DNA molecule is operably connected to a subject open reading frame (directly or indirectly) and positioned upstream (i.e., 5') from the 5' end of the subject open reading frame. For example, positioned upstream (i.e., 5') from a translation initiation element (e.g., start codon) of a subject open reading frame to be translated; or positioned upstream (i.e., 5') from a transcription initiation element of a subject open reading frame to be transcribed.

[0071] As used herein, the term “5' spacer element” refers to an spacer element that when positioned within the context of a translatable RNA molecule or a transcribable DNA molecule is operably connected to (directly or indirectly) and positioned upstream (i.e., 5') from the 5' end ofAttorney Docket No.: 62801.85 WO01a subject open reading frame. For example, positioned upstream (z.e., 5') from a translation initiation element (e.g., start codon) of a subject open reading frame to be translated; or positioned upstream (z.e., 5') from a transcription initiation element of a subject open reading frame to be transcribed.

[0072] As used herein, the term “3' untranslated region” or “3' UTR” refers to an untranslated nucleic acid molecule when within the context of a translatable RNA molecule or a transcribable DNA molecule is operably connected to a subject open reading frame (directly or indirectly) and positioned downstream (z.e., 3') from the 3' end of the subject open reading frame. For example, positioned downstream (z.e., 3’) from a translation termination element (e.g., stop codon) of a subject open reading frame to be translated; or positioned upstream (z.e., 3') from a transcription termination element of a subject open reading frame to be transcribed.

[0073] As used herein, the term “3' spacer element” refers to a spacer element that when positioned within the context of a translatable RNA molecule or a transcribable DNA molecule is operably connected to (directly or indirectly) and positioned downstream (z.e., 3') from the 3' end of a subject open reading frame. For example, positioned downstream (z.e., 3') from a translation termination element (e.g., stop codon) of a subject open reading frame to be translated; or positioned downstream (z.e., 3') from a transcription termination element of a subject open reading frame to be transcribed.

[0074] As used herein, the term “3' poly(A) sequence” refers to a poly(A) sequence that when positioned within the context of a translatable RNA molecule or a transcribable DNA molecule is operably connected to (directly or indirectly) and positioned downstream (z.e., 3') from the 3' end of a subject open reading frame. For example, positioned downstream (z.e., 3') from a translation termination element (e.g., stop codon) of a subject open reading frame to be translated. In some embodiments, the 3' poly(A) sequence is positioned downstream (z.e., 3') from a 3' UTR. The average length of a 3' poly(A) sequence is 50-300 nucleotides, e.g., 150-250 nucleotides. A 3' poly(A) sequence aids in RNA stability and translation.

[0075] As used herein, the term “administering” refers to the physical introduction of an agent, e.g., a therapeutic agent (or a precursor of the therapeutic agent that is metabolized or altered within the body of the subject to produce the therapeutic agent in vivo) (e.g., a therapeutic protein) or a composition (e.g., a pharmaceutical composition composing the therapeutic agent (e.g., therapeutic protein)) to a subject, using any of the various methods and delivery systems knownAttorney Docket No.: 62801.85 WO01to those skilled in the art. Administering can also be performed, for example, once, a plurality of times, and / or over one or more extended periods. Therapeutic agents include agents whose effect is intended to be preventative (i.e., prophylactic). The term administering includes selfadministration by the subject and administration by another.

[0076] As used herein, the term “antibody” or “antibodies” is used in the broadest sense and encompasses various immunoglobulin (Ig) (e.g., human Ig (hlg)) structures, including, but not limited to monoclonal antibodies, polyclonal antibodies, multispecific (e.g., bispecific, trispecific) antibodies, and antibody fragments so long as they exhibit the desired antigen-binding activity (i.e., antigen binding fragments as defined herein). The term antibody thus includes, for example, full-length antibodies; antigen-binding fragments of full-length antibodies; molecules comprising antibody CDRs, VH regions, and / or VL regions; and antibody-like scaffolds (e.g., fibronectins). Examples of antibodies include, without limitation, monoclonal antibodies, polyclonal antibodies, monospecific antibodies, multispecific antibodies, human antibodies, humanized antibodies, chimeric antibodies, camelized antibodies, intrabodies, affybodies, diabodies. tribodies, heteroconjugate antibodies, antibody-drug conjugates, single domain antibodies (<?.#., VHH, (VHHjz), single chain antibodies, single-chain Fvs (scFv; (scFvjz), Fab fragments (e.g., Fab, single chain Fab (scFab), F(ab’)2 fragments, di sulf ide-linked Fvs (sdFv), Fc fusions (e.g., Fab-Fc, scFv-Fc, VHH-Fc, (SCFV)2-FC, (VHH)2-FC), and antigen-binding fragments of any of the above, and conjugates or fusion proteins comprising any of the above. Antibodies can be of Ig isotype (e.g., IgG, IgE, IgM, IgD, or IgA), any class e.g., IgGi, IgG2, IgGs, IgG4, IgAi or IgA?), or any subclass (e.g., IgG2a or IgG2b) of Ig). In certain embodiments, antibodies described herein are IgG antibodies, or a class (e.g., human IgGi or IgG4) or subclass thereof. In some embodiments, the antibody is a human, humanized, or chimeric IgGi or IgG4 monoclonal antibody. In some embodiments, the term antibodies refers to a monoclonal or polyclonal antibody population.

[0077] As used herein, the term “immunogen” refers to a substance (e.g., a peptide or protein) that is capable of inducing an immune response (e.g., an adaptive immune response) in a subject (e.g., a human).

[0078] As used herein, the terms “circRNA,” “circular RNA molecule,” are used interchangeably and refer to an RNA molecule that has a structure having no free ends (i.e., no free 3' and / or 5' ends), for example an RNA molecule that forms a circular or end-less structure through covalent (e.g., covalently closed) or non-covalent bonds. The circular RNA molecule mayAttorney Docket No.: 62801.85 WO01be e.g., a covalently closed RNA molecule.

[0079] As used herein, the term “co-administering” and the like refers to the physical introduction of different therapeutic agents (or a precursor of the therapeutic agent that is metabolized or altered within the body of the subject to produce the therapeutic agent in vivo) (e.g., a therapeutic protein)) or different compositions (e.g., different pharmaceutical compositions each comprising a different therapeutic agent e.g., a different therapeutic protein)) to the same subject. The different therapeutic agents or compositions (e.g., pharmaceutical compositions) may be administered simultaneously, at essentially the same time, or sequentially.

[0080] As used herein, the term “disease” refers to any abnormal condition that impairs physiological function. The term is used broadly to encompass any disorder, illness, abnormality, pathology, sickness, condition, or syndrome in which physiological function is impaired, irrespective of the nature of the etiology. The term disease includes infection (e.g., viral, bacterial, fungal, yeast, parasitic infection).

[0081] As used herein, the term “derived from,” with reference to a nucleic acid molecule refers to a nucleic acid molecule that has at least 70% sequence identity to a reference nucleic acid molecule (e.g., a naturally occurring nucleic acid molecule) or a fragment thereof. The term “derived from,” with reference to a protein refers to a protein that comprises an amino acid sequence that has at least 70% sequence identity to the amino acid sequence of a reference protein (e.g., a naturally occurring protein). The term “derived from” as used herein does not denote any specific process or method for obtaining the nucleic acid molecule, polypeptide, or protein. For example, the nucleic acid molecule, polypeptide, or protein can be recombinantly produced or chemically synthesized.

[0082] The terms “DNA” molecule and “polydeoxyribonucleotide” are used interchangeably herein and refer to macromolecules that include multiple deoxyribonucleotides that are polymerized via phosphodiester bonds. Deoxyribonucleotides are nucleotides in which the sugar is deoxyribose.

[0083] As used herein, the term “enhancer” refers to a nucleic acid sequence that which typically acts on the activity of a promoter in the cis location and thus stimulates the transcription of a coding region operably connected to the promoter. Usually, the effect of an enhancer is fairly independent of the position and orientation and therefore it may be positioned directly or indirectly 5’ or 3’ of a promoter. The enhancer may be located in the immediate vicinity of the coding regionAttorney Docket No.: 62801.85 WO01or the promoter, or at a considerable distance from the promoter.

[0084] The term “functional variant” as used herein in reference to a protein refers to a protein that comprises at least one but no more than 15%, not more than 12%, no more than 10%, no more than 8% amino acid variation {e.g., substitution, deletion, addition) compared to the amino acid sequence of a reference protein, wherein the protein retains at least one particular function of the reference protein. Not all functions of the reference protein {e.g., wild type) need be retained by the functional variant of the protein. In some instances, one or more functions are selectively reduced or eliminated. In some embodiments, the reference protein is a wild type protein.

[0085] The term “functional fragment” as used herein in reference to a protein refers to a fragment of a reference protein that retains at least one particular function. Not all functions of the reference protein need be retained by a functional fragment of the protein. In some instances, one or more functions are selectively reduced or eliminated. In some embodiments, the reference protein is a wild type protein.

[0086] As used herein, the term “fusion protein” and grammatical equivalents thereof refers to a protein that comprises at least one polypeptide operably connected to another polypeptide, wherein the first and second polypeptides are not naturally found operably connected together. For example, the first and second polypeptides of the fusion protein are each derived from different proteins. The at least two polypeptides of the fusion protein can be directly operably connected through a peptide bond; or can be indirectly operably connected through a linker {e.g., a peptide linker). Therefore, for example, the term fusion polypeptide encompasses embodiments, wherein Polypeptide A is directly operably connected to Polypeptide B through a peptide bond (Polypeptide A - Polypeptide B), and embodiments, wherein Polypeptide A is operably connected to Polypeptide B through a peptide linker (Polypeptide A - peptide linker - Polypeptide B).

[0087] As used herein, the term “heterologous”, when used to describe a first element in reference to a second element means that the first element and second element do not exist in nature disposed as described. For example, a polypeptide comprising a “heterologous moiety” means a polypeptide that is joined to a moiety {e.g., small molecule, polypeptide, nucleic acid molecule, carbohydrate, lipid, synthetic polymer {e.g., polymers of PEG), etc.) that is not joined to the polypeptide in nature.

[0088] As used herein, the term “intron” refers to a non-coding nucleotide portion of a sequence that is transcribed and subsequently removed by splicing during formation of the matureAttorney Docket No.: 62801.85 WO01RNA.

[0089] The term “inverted terminal repeat” or “ITR” as used herein refers to the art-recognized regions found at the 5' and 3' termini of adeno associated virus (AAV) genomes which function in cis as origins of DNA replication and as packaging signals for the viral genome.

[0090] As used herein, the term “isolated” with reference to a protein or polynucleotide refers to a protein or polynucleotide that is substantially free of other cellular components with which it is associated in the natural state.

[0091] As used herein, the terms “linear RNA molecule” refers to an RNA molecule having a 5' and 3' end. One or both of the 5' and 3' ends may be free ends or joined to another moiety. In some embodiments, the linear RNA has a 5' end or 3' end that is modified or protected from degradation (e.g., by a 5' end protectant or a 3' end protectant). In some embodiments, the linear RNA has non-covalently linked 5' or 3' ends. Linear RNA includes mRNA molecules. Linear RNA includes RNA that has not undergone circularization e.g., is pre-circularized) and can be used as a starting material for circularization.

[0092] As used herein, the term “modified nucleotide,” “nucleotide modification,” or use of the term “modification” and the like in reference to a nucleotide or nucleic acid sequence refers to a nucleotide comprising a chemical modification, e.g., a modified sugar moiety, a modified nucleobase, and / or a modified intemucleoside linkage, or any combination thereof. Exemplary modifications are provided herein, see, e.g., § 5.6.5, §5.7.3. In certain embodiments of the instant disclosure, inclusion of a deoxynucleotide - which is acknowledged as a naturally occurring form of nucleotide - if present within an RNA molecule is considered to constitute a modified nucleotide.

[0093] The terms “nucleic acid molecule” and “polynucleotide” are used interchangeably herein and refer to a polymer of DNA or RNA. The nucleic acid molecule can be single- stranded or double-stranded; contain natural, non-natural, or altered nucleotides; and contain a natural, nonnatural, or altered intemucleotide linkage, such as a phosphoroamidate linkage or a phosphorothioate linkage, instead of the phosphodiester found between the nucleotides of an unmodified nucleic acid molecule. Nucleic acid molecules include, but are not limited to, all nucleic acid molecules which are obtained by any means available in the art, including, without limitation, recombinant means, e.g., the cloning of nucleic acid molecules from a recombinant library or a cell genome, using ordinary cloning technology and polymerase chain reaction, andAttorney Docket No.: 62801.85 WO01the like, and by synthetic means. The skilled artisan will appreciate that, except where otherwise noted, nucleic acid sequences set forth in the instant application will recite thymidine (T) in a representative DNA sequence but where the sequence represents RNA {e.g., mRNA), the thymidines (Ts) would be substituted for uracils (Us). Thus, any of the RNA polynucleotides encoded by a DNA identified by a particular sequence identification number may also comprise the corresponding RNA {e.g., mRNA) sequence encoded by the DNA, where each thymidine (T) of the DNA sequence is substituted with uracil (U).

[0094] As used herein, the term “open reading frame” or “ORF” refers to a region of a nucleic acid molecule e.g., RNA molecule) that encodes a protein or functional RNA transcript {e.g., a tRNA). When an ORF encodes a protein, the ORF will typically include a plurality of nucleotide triads, each of which can code for an amino acid and is termed as a codon.

[0095] As used herein, the term “operably connected” refers to the linkage of two moieties in a functional relationship such that each moiety can mediate its function post linkage. For example, a polypeptide is operably connected to another polypeptide when they are linked (either directly or indirectly via a peptide linker) in frame such that both polypeptides are functional {e.g., a fusion protein described herein). Or for example, a transcription regulatory polynucleotide e.g., a promoter, enhancer, or other expression control element is operably linked to a polynucleotide that encodes a protein if it affects the transcription of the polynucleotide that encodes the protein. Operable connection of the moieties can be direct or indirect {e.g., operably linked through another moiety).

[0096] As used herein, the term “pharmaceutical composition” means a composition that is suitable for administration to an animal, e.g., a human subject, and comprises a therapeutic agent and a pharmaceutically acceptable carrier or diluent. A “pharmaceutically acceptable carrier or diluent” means a substance for use in contact with the tissues of human beings and / or non-human animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable therapeutic benefit / risk ratio.

[0097] As used herein, the term “poly(A) sequence” refers to an untranslated contiguous nucleotide sequence at least 50 nucleotides in length and consisting of adenine residues, and which aids in the stability and translation of a translatable RNA {e.g., mRNA or translatable circular RNA). Similar terms are utilized throughout, such as “poly(A-U) sequence”, which likewise would refer to an untranslated contiguous nucleotide sequence at least 5 nucleotides in length andAttorney Docket No.: 62801.85 WO01consisting of adenine and uracil residues.

[0098] As used herein, a “poly(A) signal sequence” encompasses a recognition region necessary for endonuclease cleavage of an RNA transcript that is followed by the poly adenylation consensus sequence AATAAA. A poly(A) signal sequence provides a “polyA site”, i.e., a site on a RNA transcript to which adenine residues will be added by post-transcriptional polyadenylation.

[0099] As used herein, a “posttranscriptional regulatory element” refers to a non-coding portion of a nucleotide sequence that is transcribed and functions to regulate post-transcription RNA molecules. PREs can function by, e.g., promoting RNA export from the nucleus to the cytoplasm, enhancing 3' end processing and stability. See, e.g., Sun J, Li D, Hao Y, Zhang Y, Fan W, Fu J, Hu Y, Liu Y, Shao Y. Posttranscriptional regulatory elements enhance antigen expression and DNA vaccine efficacy. DNA Cell Biol. 2009 May;28(5):233-40. doi: 10.1089 / dna.2009.0862. PMID: 19388846; PMCID: PMC2719066, the entire contents of which are incorporated by reference herein for all purposes.

[0100] As used herein, the term “promoter” refers to a nucleic acid sequence (e.g., DNA sequence) that can be operably connected to a nucleic acid sequence encoding a transcript (e.g., tRNA) or protein (e.g., operably connected upstream of the coding sequence) that mediates initiation of transcription of the coding sequence through the recruitment of relevant proteins (e.g., RNA polymerase, transcription factors, etc.) to the promoter (e.g., through binding of one or more of the proteins to a portion the promoter sequence). The resulting transcription produces an RNA molecule. The RNA molecule can encode a protein (e.g., an mRNA molecule) or the RNA molecule can itself serve a biological function (e.g., a tRNA, rRNA). Promoters can influence e.g., the rate of transcription of coding sequences to which they are operably connected.

[0101] As used herein, the terms “protein” and “polypeptide” refers to a polymer of at least 2 (e.g., at least 5) amino acids linked by a peptide bond. The term “polypeptide” does not denote a specific length of the polymer chain of amino acids. It is common in the art to refer to shorter polymers of amino acids (e.g., approximately 2-50 amino acids) as peptides; and to refer to longer polymers of amino acids (e.g., approximately over 50 amino acids) as polypeptides. However, the terms “peptide” and “polypeptide” and “protein” are used interchangeably herein. In some embodiments, the protein is folded into its three-dimensional structure. Where polypeptides are contemplated herein, it should be understood that proteins folded into their three-dimensional structure are also provided herein.Attorney Docket No.: 62801.85 WO01

[0102] As used herein, the term “regulatory element” includes moieties, such as nucleic acid sequences that modify expression (e.g., transcription or translation of an open reading frame (e.g., within a translatable RNA molecule or a transcribable DNA molecule).

[0103] The terms “RNA” molecule and “polyribonucleotide” are used interchangeably herein and refer to macromolecules that include multiple ribonucleotides that are polymerized via phosphodiester bonds. Ribonucleotides are nucleotides in which the sugar is ribose. RNA may contain modified nucleotides; and contain natural, non-natural, or altered intemucleotide linkages, such as a phosphoroamidate linkage or a phosphorothioate linkage, instead of the phosphodiester found between the nucleotides of an unmodified nucleic acid molecule.

[0104] As used herein, the term “spacer element” refers to any untranslated contiguous nucleotide sequence (e.g., of one or more nucleotides) that provides distance or flexibility between two adjacent polynucleotide regions. Spacer elements may be present in between any of the nucleic acid elements described herein. Spacer elements may also be present within a nucleic acid element described herein.

[0105] As used herein, the term “stagger element” refers to a moiety, such as a nucleotide sequence, that induces ribosomal pausing during translation.

[0106] As used herein, the term “subject” includes any animal, such as a human or other animal. In embodiments, the subject is a vertebrate animal (e.g., mammal, bird, fish, reptile, or amphibian). In embodiments, the subject is a human. In embodiments, the method subject is a nonhuman mammal. In embodiments, the subject is a non-human mammal is such as a non-human primate (e.g., monkeys, apes), ungulate (e.g., cattle, buffalo, sheep, goat, pig, camel, llama, alpaca, deer, horses, donkeys), carnivore (e.g., dog, cat), rodent (e.g., rat. mouse), or lagomorph (e.g., rabbit). In embodiments, the subject is a bird, such as a member of the avian taxa Galliformes (e.g., chickens, turkeys, pheasants, quail), Anseriformes (e.g., ducks, geese), Paleaognathae (e.g., ostriches, emus). Columbiformes (e.g., pigeons, doves), or Psittaciformes (e.g., parrots).

[0107] As used herein, the term “therapeutic protein” or “therapeutic polypeptide” refers to a protein that is intended for the preventing, treatment, and / or amelioration of a disease. The therapeutic protein may have a direct therapeutic effect or an indirect therapeutic effect. For example, the therapeutic protein may target a cell to a specific target (e.g., a target cell or tissue), wherein the cell (e.g., an agent, e.g., a protein secreted from the cell) mediates a direct therapeutic effect. The term also includes proteins intended for prophylactic (preventive) use (e.g., use inAttorney Docket No.: 62801.85 WO01vaccines, etc.).

[0108] As used herein, the term “therapeutically effective amount” of a therapeutic agent (e.g., a therapeutic protein) refers to any amount of the therapeutic agent that, when used alone or in combination with another therapeutic agent, protects a subject against the onset of a disease (or infection) or promotes disease (or infection) regression evidenced by a decrease in severity of disease of infection symptoms, an increase in frequency and duration of disease or infection symptom-free periods, or a prevention of impairment or disability due to the disease or infection affliction. The ability of a therapeutic agent to promote disease regression can be evaluated using a variety of methods known to the skilled practitioner, such as in human subjects during clinical trials, in animal model systems predictive of efficacy in humans, or by assaying the activity of the agent in in vitro assays.

[0109] As used herein, the term “translatable RNA” refers to any RNA that encodes at least one polypeptide and can be translated to produce the encoded protein in vitro, in vivo, in situ or ex vivo. A translatable RNA may be an mRNA or a circular RNA encoding a polypeptide.

[0110] As used herein, the term “transcribable DNA” refers to any DNA that encodes at least one open reading frame and can be transcribed to produce the encoded protein or RNA of the open reading frame.

[0111] As used herein, the term “translational regulatory element” is a moiety, such as a nucleic acid sequence, that modifies expression of an open reading frame within a translatable RNA molecule.

[0112] As used herein, the term “transcriptional regulatory element” is a moiety, such as a nucleic acid sequence, that modifies transcription of an open reading frame within a transcribable DNA molecule.

[0113] As used herein, the term “translation termination element” refers to a moiety such as a nucleic acid sequence, that terminates translation of the expression sequence in a translatable RNA molecule (e.g., a stop codon).

[0114] As used herein, the term “translation initiation element” refers to a moiety such as a nucleic acid sequence, that initiates translation of an open reading frame in a translatable RNA molecule (e.g., a start codon).

[0115] As used herein, the terms “treat,” treating,” “treatment,” and the like refer to reducing, ameliorating, or preventing a disease or infection and / or symptom(s) associated therewith orAttorney Docket No.: 62801.85 WO01obtaining a desired pharmacologic and / or physiologic effect. It will be appreciated that, although not precluded, treating a disease or infection does not require that the disease or infection, or symptom(s) associated therewith be completely eliminated or prevented. In some embodiments, the effect is therapeutic, i.e., without limitation, the effect partially or completely reduces, diminishes, abrogates, abates, alleviates, decreases the intensity of, or cures a disease and / or adverse symptom attributable to the disease or infection. In some embodiments, the effect is preventative, i.e., the effect protects or prevents an occurrence or reoccurrence of a disease or infection. To this end. the presently disclosed methods comprise administering a therapeutically effective amount of a compositions as described herein.

[0116] As used herein, the term “variant” or “variation” with reference to a polynucleotide, refers to a polynucleotide sequence that comprises at least one substitution, alteration, inversion, addition, or deletion of nucleotide compared to a reference polynucleotide sequence. As used herein, the term “variant” or “variation” with reference to a protein refers to a peptide or protein that comprises at least one substitution, alteration, inversion, addition, or deletion of an amino acid residue compared to a reference protein.5.2 5' Untranslated Regions

[0117] In one aspect, provided herein are 5' untranslated regions (UTRs) (and nucleic acid molecules comprising the same (e.g., RNA molecules (e.g., translatable RNA molecules), DNA molecules). The nucleotide sequence of 5' UTRs-1-1513 (SEQ ID NOS: 1506-3018, respectively) is set forth below in Table 1. For the sake of convenience, “U” is utilized in Table 1. It should be understood that “T” would take the place of “U” in the corresponding DNA sequence. Thus, throughout this application it will be understood that where RNA sequences are described, “U” in the RNA sequence will be replaced with “T” in the corresponding DNA sequences. As such, every RNA sequence utilizing “U” does not need to be explicitly recited only replacing each “U” with “T”. The sequences with “U” or “T” are specifically contemplated herein.Table 1. Nucleotide Sequence of 5' Untranslated Regions.5' UTR SEQ Nucleotide SequenceID ID NO GGGUCCCGCAGUCGGCGUCCAGCGGCUCUGCUUGUUCGUGUGUGUGUCGUUGCAGGCCUU1 AUUC 1506 2 GAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1507 3 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 15084 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAC CCCGGCGCGCCACC 1509Attorney Docket No.: 62801.85WO01ACUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACACC 1510 UCUCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACUUCUAUU GCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGAAAAUUUUCACCAUUU 1511 ACGAACGAUAGC AUUCCUUUCCCACCGCUCCUUCGCUUUCCCUUCCUCGCCCGCCGUAAUAAAUAGACACCC CCUCCACACCCUCUUUCCCCAACCUCGUGUUGUUCGGAGCGCACACACACACAACCAGAU 1512 CUCCCCCAAAUCCACCCGUCGGCACCUCCGCUUCAAG UUCAUAGUCAUGGCAUUAGCUU 1513 GU UAAAAUAGUAGC GCG 1514 GUUAAAAAGUGCGCCCUUAGCGAAG 1515 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAC CCCGGCGCCGC C AC C 1516 AGGAGAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAC CCCGGCGCCGCCACC 1517 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGC C AC C 1518 AGGAGAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGCCACC 1519 AGAAUAAAC UAGUAUUC UUC UGGUC C C C AC AGAC UC AGAGAGAAC C C GC C AC C 1520 AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1521 AGGAGAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1522 AGAUUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1523 AGACGAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1524 GGGCGAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1525 AGGAGAAAGCUUACC 1526 AGGAGAGUCCCGCAGUCGGCGUCCAGCGGCUCUGCUUGUUCGUGUGUGUGUCGUUGCAGG CCUUAUUCAAGCUUACC 1527 GUCCCGCAGUCGGCGUCCAGCGGCUCUGCUUGUUCGUGUGUGUGUCGUUGCAGGCCUUAU UC 1528 GCCUCUGCUGGAGUCCGGGGAGUGGCGUUGGCUGCUAGAGCG 1529 GCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGC GGAGUAACUGCAAAG 1530 CUUUCCCAUUCUGUAGCAGAAUUUGGUGUUGCCUGUGGUCUUGGUCCCGCGGAG 1531 GUCCGCUCAGCCAGGUUGCAGAAGCGGCUUAGCGUGUGUCCUAAUCUUCUCUCUGCGUGU AGGUAGGCCUGUGCCGCAAAC 1532 CUCCUGUCGGGCGGAAGUAGGAGGAGUAGAGUUUAAAAACAGUACUCUUUUUCCGGUUCG GGACGUAGUUGAAGCAACGACAAGCCGGAUAACCGCUCUUGAGACAGG 1533 CCCGUGACCCGGAAGUUGUACGGCUACGCGACUUUCCCUCCCACAAACCCUCGCGCCCUU CCUUUCCUACUUGGGCCCGGCAGA 1534 GGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCUCGGCAUC 1535 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGA 1536 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAC CCCGGCGCCACC 1537 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUUUAAGAGCCACC 1538 UCAAGCUUUUGGACCCUCGUACAGAAGCUAAUACGACUCACUAUAGGGAAAUAAGAGAGA AAAGAAGAGUAAGAAGAAAUAUAAGAGC C AC C 1539 UGAUAAUAGUCCAUAAAGUAGGAAACACUACAGCUGGAGCCUCGGUGGCCAUGCUUCUUG CCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUU 1540 GAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCUCCAUAAAGUAGGAAACACUACACAUGCUUCUUG CCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUU 1541 GAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUCCAUAAAGUAGGAAACA CUACAUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUU 1542 GAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGUCC AUAAAGUAGGAAACACUACACCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUU 1543GAAUAAAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCC CUCCUCCCCUUCUCCAUAAAGUAGGAAACACUACACUGCACCCGUACCCCCGUGGUCUUU 1544 GAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCC CUCCUCCCCUUCCUGCACCCGUACCCCCUCCAUAAAGUAGGAAACACUACAGUGGUCUUU 1545 GAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCC CUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUUCCAUAAAGUAGGA 1546 AACACUACACUGAGUGGGCGGC GGGAGAUCAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGCCACC 1547 GGAAUAAAAGUCUCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUC UACUUCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGAAAAUU 1548 UUCACCAUUUACGAACGAUAGCAAC GGAGACAAGCUUGGCAUUCCGGUACUGUUGGUAAAGCCACC 1549 GGGAGACAAGCUUGGCAUUCCGGUACUGUUGGUAAAGCCACC 1550 GGGAAUUAACAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGCCACC 1551 GGGAAAUUAGACAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGCCACC 1552 GGGAAAUAAGAGAGUAAAGAAC AGUAAGAAGAAAUAUAAGAGC C AC C 1553 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAUAUAUAAGAGCCACC 1554 GGGAAAUAAGAGACAAAACAAGAGUAAGAAGAAAUAUAAGAGCCACC 1555 GGGAAAUUAGAGAGUAAAGAACAGUAAGUAGAAUUAAAAGAGCCACC 1556 GGGAAAUAAGAGAGAAUAGAAGAGUAAGAAGAAAUAUAAGAGCCACC 1557 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAAUUAAGAGCCACC 1558 ACAGGACGACCCAAGCAAGCAAGCAAGCAGCGAGUACAUACAUACUAGGCAGCCAGGCAG CC 1559 ACAUUUGCUUCUGACACAACUGUGUUCACUAGCAACCUCAAACAGACACC 1560 AAGCUCAGAAUAAACGCUCAACUUUGGCC 1561 CAGGGUCCUGUGGACAGCUCACCAGCU 1562 UCCCGCAGUCGGCGUCCAGCGGCUCUGCUUGUUCGUGUGUGUGUCGUUGCAGGCCUUAUUC 1563 CAGAUCGCCUGGAGACGCCAUCCACGCUGUUUUGACCUCCAU 1564 GAGAGGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCUCGGCAUC 1565 ACCGCCAUCUUGGCUCCUGUGGAGGCCUGCUGGGAACGGGACUUCUAAAAGGAACU 1566 GGUUCCUCUUUCCUCGCUCAAG 1567 CUUCCUUUCCCUGCU 1568 GCUACAAGCUUGGGCUUAUCCCGCCU 1569 UCGAUCCAUGGGGUUGCGGUGAUGGU 1570 CUGCAGGUUAAUUAAGGAAGGGCGAAUUCUGCAGAUAUCCAUCACACUGGCGGCCGCUCG AGCAUGCAUCUAGAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUUCACUGGCCC 1571 C U AUC UAAUAAUAUAC C UUAUAC UGGAC UA CGAUCGCGUUUAAACAAGGGCGAAUUCCAGCACACUGGCGGCCGUUACUAGUGGAUCCGA GCUCGGUACCAAGCUUGAUGCAUAGCUUGAGUAUUCUAUAGUGUCACCUAAAUAGCUUGG 1572 C C C UAUC UAAAUAUAUAC C UUAUAC UGGAC CGAUCGCGUUUAAACAAGGGCGAAUUCCAGCACACUGGCGGCCGUUACUAGUGGAUCCGA GCUCGGUACCAAGCUUGAUGCAUAGCUUGAGUAUUCUAUAGUGUCACCUAAAUAGCUUGG 1573 CCAUCAUCAAUAAUAUACCUUACACUGGAC UUUAAACCUAUCUAUAUAAUAUACCUUAUAGAUGGAAUGGUGCCAACAUGUAAAUGAGGU AAUUUAAAAAAGUGCGCGCUGUGUGGUGAUUGGCUGCGGGGUUAACGGCUAAAAGGGGCG 1574 GCGCGACCGUGGGAAAAUGACGUGACUUAU AGACCAAAACGAUCUCAAGCGAUCGCGUUUAAACAAGGGCGAAUUCCAGCACACUGGCGG CCGUUACUAGUGGAUCCGAGCUCGGUACCAAGCUUGAUGCAUAGCUUGAGUAUUCUAUAG 1575UGUCACCUAAAUAGCUUGGCCAUCAUCAAUAttorney Docket No.: 62801.85WO01CCUGCAGGCAUUAUCAAUAAUAUACCUUAUAGAUGGAAUGGUGCCAACAUGUAAAUGAGG UAAUUUAAAAAAGUGCGCGCUGUGUGGUGAUUGGCUGCGGGGUGAACGGCUAAAAGGGGC 1576 GGGCAAUGCUGGGAUGUGACGUAACUUAUG CUGCAGGUUAAUUAAGGAAGGGCGAAUUCUGCAGAUAUCCAUCACACUGGCGGCCGCUCG AGCAUGCAUCUAGAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUUCACUGGCCU 1577 AUUAUAUAAUAUACCUUAUAGAUGGAAUGG CUGCAGGUUAAUUAAGGAAGGGCGAAUUCUGCAGAUAUCCAUCACACUGGCGGCCGCUCG AGCAUGCAUCUAGAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUUCACUGGCCC 1578 AAUCAAUAUAAUAUACCUUAUAGAUGGAAU CGAUCGCGUUUAAACAAGGGCGAAUUCCAGCACACUGGCGGCCGUUACUAGUGGAUCCGA GCUCGGUACCAAGCUUGAUGCAUAGCUUGAGUAUUCUAUAGUGUCACCUAAAUAGCUUGG 1579 CCAUCAUCAAUAAUAUACCUUAUAGAUGGA CUGCAGGUUAAUUAAGGAAGGGCGAAUUCUGCAGAUAUCCAUCACACUGGCGGCCGCUCG AGCAUGCAUCUAGAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUUCACUGGCCC 1580 AUCAUCAAUAAUAUACCUUAUAGAUGGAAU AAUUGCUGAUUUGCGCGCGAAAACUGAAUGAGGAAGUGUUUUUCUGAAUAAUGUGGUAUU UAUGGCAGGGUGGAGUAUUUGUUCAGGGCCAGGUAGACUUUGACCCAUUACGUGGAGGUU 1581 UCGAUUACCGUGUUUUUUACCUGAAUUUCC CGAUCGCGUUUAAACAAGGGCGAAUUCCAGCACACUGGCGGCCGCUCGAGCAUGCAUCUA GAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUGCACUGGCCCAUCAUCAAUAAU 1582 AUACCUUAUAGAUGGAAUGGUGCCAAUAUG UUAAUUAACAUCAUCAAUAAUAUACCUUAUUUUGGAUUGAAGCCAAUAUGAUAAUGAGGG GGUGGAGUUUGUGACGUGGCGCGGGGCGUGGGAACGGGGCGGGUGACGUAGUAGUGUGGC 1583 GGAAGUGUGAUGUUGCAAGUGUGGCGGAAC UUUAAAUCAUCAUCAAUAAUAUACCUUAUUUUGGAUUGAAGCCAAUAUGAUAAUGAGGGG GUGGAGUUUGUGACGUGGCGCGGGGCGUGGGAACGGGGCGGGUGACGUAGUAGUGUGGCG 1584 GAAGUGUGAUGUUGCAAGUGUGGCGGAACA UUUUAAAUCAUCAUCAAUAAUAUACCUUAUUUUGGAUUGAAGCCAAUAUGAUAAUGAGGG GGUGGAGUUUGUGACGUGGCGCGGGGCGUGGGAACGGGGCGGGUGACGUAGUAGUGUGGC 1585 GGAAGUGUGAUGUUGUAAGUGUGGCGGAAC CGAUCGCGUUUAAACAAGGGCGAAUUCCAGCACACUGGCGGCCGUUACUAGUGGAUCCGA GCUCGGUACCAAGCUUGAUGCAUAGCUUGAGUAUUCUAUAGUGUCACCUAAAUAGCUUGG 1586 C C U AUC UAUAUAAUAUAC C C C AC AAAGUAA CUGCAGGUUAAUUAAGGAAGGGCGAAUUCUGCAGAUAUCCAUCACACUGGCGGCCGCUCG AGCAUGCAUCUAGAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUUCACUGGCCC 1587 C AUC UAUAUAAUAUAC C C C AC AAAGUAAAC CAUCAUCAAUAAUAUACCCCACAAAGUAAACAAAAGUUAAUAUGCAAAUGAGGUUUUAAA UUUAGGGCGGGGCUACUGCUGAUUGGCCGAGAAACGUUGAUGCAAAUGACGUCACGACGC 1588 ACGGCGUUAACGGUCGCCGCGGAGGCGUGG CAUCAUCAAUAAUAUACCCCACAAAGUAAACAAAAGUUAAUAUGCAAAUGAGGUUUUAAA UUUAGGGCGGGGCUACUGCUGAUUGGCCGAGAAACGUUGAUGCAAAUGACGUCACGACGC 1589 ACGGCUAACGGUCGCCGCGGAGGCGUGGCC CAUCAUCAAUAAUAUACCCCACAAAGUAAACAAAAGUUAAUAUGUAAAUGAGCUUUUGAA UUUAGGGCGGGGCCGACGCUGAUUGGCCGUUGCAAGAACCGUUAGUGACGUCACGACGCA 1590 CGGCCGACGGCCGCCGCGGAGGCGUGGCCU CAUCAUCAAUAAUAUACCCCACAAAGUAAACAAAAGUUAACAUGCAAAUGAGCUUUUGAA UUUAGGGCGGGGCCAGCGCUGAUUGGACGAGAGAAGAUGAUGCAAAUGACGUCACGACGC 1591 ACGGCUAACGGUCGCCGCGGAGGCGUGGCC CAUCAUCAAUAAUAUACCCCACAAAGUAAACAAAAGUUAAUAUGCAAAUGAGGUUUUAAA UUUAGGGCGGGGCUACUGCUGAUUGGACGAGAAACGGUGAUGCAAAUGACGUCACGACGC 1592 ACGGCUAACGGUCGCCGCGGAGGCGUGGCC AUCAUCAAUAAUAUACCCCACAAAGUAAACAAAAGUUAAUAUGCAAAUGAGCUUUUGAAU UUUAACGGUUUUGGGGCGGAGCCAACGCUGAUUGGACGAGAAGCGGUGAUGCAAAUAACG 1593UCACGACGCACGGCUAACGGCCGGCGCGGAAttorney Docket No.: 62801.85WO01AUCAUCAAUAAUAUACCUUAUUUUUUUUGUGUGAGUUAAUAUGCAAAUAAGGCGUGAAAA UUUGGGGAUGGGGCGCGCUGAUUGGCUGUGACAGCGGCGUUCGUUAGGGGCGGGGCAGGU 1594 GACGUUUUGAUGACGCGACUAUGAGGAGGA CUGCAGGUUAAUUAAGGAAGGGCGAAUUCUGCAGAUAUCCAUCACACUGGCGGCCGCUCG AGCAUGCAUCUAGAGGGCCCAAUUCGCCCUAUAGUGAGUCGUAUUACAAUUCACUGGCCC 1595 AUCAUCAAUAAUAUACCUUAAAGCUGGAAA CUUUCCCCCUACAGGACUCAG 1596 GGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGC CAC C 1597 UGAAUGCAUGAUC 1598 UUUCCAGUUGCCUAGACAACAGGCCCAGGGUCAGAGCAACAAUCCUUCCAGCCACCUGCC UCAACUGCUGCCCCAGGCACCAGCCCCAGUCCCUACGCGGCAGCCAGCCCAGGUGAC 1599 AGUCAGGAAGGACGUUGGUGUUGAGGUUAGCAUACGUAUCAAGGACAGUAACUACC 1600 GGCCGCCGCAGCCAUCUUCCAGUAACUCGCCAAA 1601 GCCAUCUUGGCGCCUGUGGAGGCCUGCUGGGAACAGGACUUCUAACAGCAAGU 1602 GGAGCGGGCGGCGGCGUUGGCGGCUUGUGCAGCA 1603 GGCCGGAACCGCCAUCUUCCAGUAAUUCGCCAAA 1604 GCCGCCCAGCCGGUCCAGGCCUCUGGCGAAC 1605 AU AGGC GGC GC AUGAGAGAAGC C C AGAC C AAUUAC C UAC C C AAA 1606 GGGCGUUCUUCCUUUUCGAUCCGCCAUCUGCGGUGGGUGUCUGCACUUCGGCUGCUCUCG GGUUAGCACCCUAUGGUGCCUUCUCUUGUGAUCCCUGACCUAACCUGUCUCUUCCUUUUC 1607 CUCAACCUCAGGUGGAGCCGCCACCAAA GGGCGCGAUCCGCCAUCUGCGGUGGGUGUCUGCACUUCGGCUGCUCUCGGGUUAGCACCC UAUGGUGCCUUCUCUUGUGAUCCCUGACCUAACCUGUCUCUUCCUUUUCCUCAACCUCAG 1608 GUGGAGCCGCCACCAAA GGGAAAGAAACAGGAC AGAAAAC AGC CAC C 1609 GGGAAC GAC AAGAAAC AC AUAC AAAAGAAAC AGGAC AGAAAAC AGC C AC C 1610 GGGAAGAGAUAAACAUAAACAUAAACGACAAGAAACACAUACAAAAGAAACAGGACAGAA AACAGCCACC 1611 GGGAACAACAGAGGAGAAGAGGGAACAGGACACAAGAGAUAAACAUAAACAUAAACGACA AGAAACACAUACAAAAGAAACAGGAC AGAAAAC AGC CAC C 1612 GGGUUUCCGAUCCGCCAUCGUGGGUGAGUGUAUGCUCUGUGGCCGCGCUCUGGCUAGUGG CGCUACGCGUCGCUCUCACGGGUGUCGUCGGAUCUAAUCCGUCUCUUUUCGAAUGCAGGU 1613 GGAGCCGCCGCCACG GGGAAAGAAAAAGAUAAGGAGAAAAAUAAAGAGAGGAAGAAAAAGCCACC 1614 GGGAAAAGUAGAAAGAAAGAAAGAAGAGAAAAUAAAGACAAAGAGCCACC 1615 GCUUUCACUAUUUCAUUCAUUUCAUUCACACAUUACACUUACAUCACAUCCACAUUACAU UUCUGCCACC 1616 GCUUUCACUAUUUCAUUCAUUUCAUUCUCUCAUUACUCUUACUUCUCUUCCUCAUUACAU UUCUGCCACC 1617 GGGGAGAAGAGGGAACAGGACACAAGAGAUAAACAUAAACAUAAACGACAAGAAACACAU AC AAAAGAAACAGGAC AGAAAAC AGC CAC C 1618 GGAAACACAAUAACAUAAUCAUACUACACAACUAACACAUACAUCACAUACACAUCACAU AACAGCCACC 1619 GGCUACACACUCUCACUCUCAUCACUCACUACUCACUCUCUCAUCACUCUCACAUCACAU CACUGCCACC 1620 GGCAAAAAUCAAAAUCAAUCAUCAUCACAACAUCAACAAUCAAUCAUCAACACAUCAUCA AGACACCACC 1621 GGAAGAGAUCAAAAGCAACAAAUCAAACAGAGAAACAAUUAGAACAAGAAACAGAAGACA ACAAGCCACC 1622 GGCAUCACACUCUCACUCUCAUCUCAACACUCCUCCUCAUUCCAAUCUCUCACACAUCCC AU U AGC CAC C 1623 GGGGAUCCGCCAUCGUGGGUGAGUGUAUGCUCUGUGGCCGCGCUCUGGCUAGUGGCGCUA CGCGUCGCUCUCACGGGUGUCGUCGGAUCUAAUCCGUCUCUUUUCGAAUGCAGGUGGAGC 1624CGCCGCCACGAttorney Docket No.: 62801.85WO01GGGGAUCCGCCAUCGUGGGUGAGUGUUAGCUCUGUGGCCGCGCUCUGGCUAGUGGCGCUA CGCGUCGCUCUCACGGGUGUCGUCGGAUCUAAUCCGUCUCUUUUCGAUAGCAGGUGGAGC 1625 CGCCGCCACG GGGAUCUAAUCCGUCUCUUUUCGAUAGCAGGUGGAGCCGCCGCCACG 1626 GGGAUCUAAUCCGUCUCUUUUCGAUAGCAGGUGGAGCCGCCGCCACGAUG 1627 GGGAGGAAAGCCUCUCUUAAUCGCAUCGGCUGUAUAAGAAAGCCUUUUGAGGCAUUUUUU UUAGUUGAGCACAUCAUUUCGAGGCCAUUCUGAGGUAAACCGAGAAAAGAGCGUAAAGAA ACCGAGCGAACGAGCAAAUCUGGCACUGCGUUAGACAGCCGCGAUUCCGCUGCAGCGCGC 1628 AGGCACGUGUGUGGCCGCCUAAGGGGCGGGUCCUUCGGCCAGGAGACCCCGUCGGCCACG CUCGGAUCUUCCUUUCCGAUCCGCCAUCGUGGGUGGAGCCGCCGCCACG GGGAGGAAAGAAUCGCAUCGGCUGUAUAAGAAAGCCUUUUGAGGCAUUUUUUUUAGUUGA GCACAUCAUUUCGAGGCCAUUCUGAGGUAAACCGAGAAAAGAGCGUAAAGAAACCGAGCG AACGAGCAAAUCUGGCACUGCGUUAGACAGCCGCGAUUCCGCUGCAGCGCGCAGGCACGU 1629 GUGUGGCCGCCUAAGGGGCGGGUCCUUCGGCCAGGAGACCCCGUCGGCCACGCUCGGAUC UUCCUUUCCGAUCCGCCAUCGUGGGUGGAGCCGCCGCCACG GGGCCCCUCGACCUCCUUUUAAAAAUUCUCUUAGCCACGUUGAUUGUACGGGAAAAGCCU UUUUAAAACAUCUUUUACGUUGCUUAAACCUACAGUUUCGAAAGCAUUCCGAAGGCUAAA GUGAGAAAUAAGCCCAGGCUAGGGAGAGGAGAAACGAAGUUCACGUCCUAGUCUGGCACC GGGUUGGAUUGUCGCUGGGACGGCAGUCAGGCAUUUGGUGUGGUCGCCUAAGGGGUGGGU 1630 CCUUCGGCGGGAGCUCCGGGAAACCCCGUGGGCCUGCGCGGCGUUCUUCCUUUUCGAUCC GCCAUCUGCGGUGGAGCCGCCACCAAA GGGAGCCACGUUGAUUGUACGGGAAAAGCCUUUUUAAAACAUCUUUUACGUUGCUUAAAC CUACAGUUUCGAAAGCAUUCCGAAGGCUAAAGUGAGAAAUAAGCCCAGGCUAGGGAGAGG AGAAACGAAGUUCACGUCCUAGUCUGGCACCGGGUUGGAUUGUCGCUGGGACGGCAGUCA 1631 GGCAUUUGGUGUGGUCGCCUAAGGGGUGGGUCCUUCGGCGGGAGCUCCGGGAAACCCCGU GGGCCUGCGCGGCGUUCUUCCUUUUCGAUCCGCCAUCUGCGGUGGAGCCGCCACCAAA AGAAACCAGGCUGUGUAAGAGCUGCUGGAGUAGGCACCCAUUUAAAGAAAAAAUGAAGAA GCAGCAAUAAAGAAGUUGUAAUCGUUACCUAGACAAACAGAGAACUGGUUUUGACAGUGU 1632 UUCUAGAGUGCUUUUUAUUAUUUUCCUGACA GGACGCCGUCCGGACAUUCGGCGCGCUUGCCACGAUCUUGGACGGGUCUCGGGCCUCGAC CUUUGAAUUCCCCGCUCCGGCUCCAAG 1633 UGCUGGGCUGCGGGGCUGCGGGGCUGCGGGUCGGGGAGGCCGGGCCGGGCCGGGCCGGGC CCCGCUGACCGCC 1634 GUCUAUGUUUGCAGAAAUACAGAUCCAAGACAAAGACAGGAUGGGCACUGCUGGAAAA 1635 UUUCUUUGAUGGAAUAGGCCCUAGGACACCUUUCUAAAAAGACUCCCUGUGGUGUUCAGA AUCACUCCUACAGUCAGGUUCUCCACA 1636 GCCUUCCGGUAUGUGGCCCCGUCUGGCUAGUCCCGCCUAGCGCGCCCAUUUCGAGCCCAA GUUUCCAGCUCGGGUUUCCAGGCUCAGAAUUUUCCAGGAGUAGGUUCUUGGGCAGUGGCU 1637 GUGGGAGCUGGA GCUGCUCGCUGCGCCACCGCCUCCCGCCACCCCUGCCCGCCCGACAGCGCCGCCGCCUGC CCCGCC 1638 AGACGUUCGCACACCUGGGUGCCAGCGCCCCAGAGGUCCCGGGACAGCCCGAGGCGCCGC GCCCGCCGCCCCGAGCUCCCCAAGCCUUCGAGAGCGGCGCACACUCCCGGUCUCCACUCG CUCUUCCAACACCCGCUCGUUUUGGCGGCAGCUCGUGUCCCAGAGACCGAGUUGCCCCAG 1639 AGAC C GAGAC GCCGCCGCUGC GAAGGAC C A AACUGCCAGUACUCAGAAGUCAGAGUUGAGAGACAGAGGCACCCCGGACAGAGACGUGAA GCACUGAAU 1640 GAGAUGCAAAC 1641 AGUAACAGUUGAUUGUUACAUUCAGUAACACUGAAUGUCAGUGCAGUCCAAUUUACAGGC UGGAGCAGCAGCUGCAUCCUGCAUUUCCCCGAAGUAUUACAUGAUUUUCACUCCUUGCAA 1642 ACUUUGCCAUCUUUGUUGCAGAGAAUCGG GCCGCGGUUUGUCGCCAGAAGGAAG 1643 AGUUUUCACUUAAACAACCAGCAAGUCUUGAAGUCUCUUCCCAAGCAAAUGGGAGCUUCU UUGGACCUUGGAGCACACAGAGGAUUCUACUUUCUUUAAAACUUUGUUUUCAGGCAAUUU 1644CCCUGAGAACCGUUUACUUCCAGAAGAUUGGUGGAGCUUGAUCUGAAGAttorney Docket No.: 62801.85WO01GCCGGCCGGGCUGUGCGGGGCGAGCGGCGGCGGCGGCGGGGGCGCUUCGGCCGGGGCGGC AGCUGGGCGCCGGCGGGAGCUAGCAGCGUCUGCAGCCGCGCCGGCCGCCAGCGCCCCGGC 1645 GCGCUCCGGCUCGGCC UUACGGUAAGUGAGGAGGGGCUGGGGUGCCCAGCGUUUUGGAUCUCCCACUCUGGCCCGG CCCCGGAAUACCACAUAGAGGCCUUGGGACCUGAUUCAUCCCGUCCAGACAGCCCUAGAG ACCUGAGCGACUGAGGCCUGGGAUCUGGACGCCGGAAUUUCCUGCGUGGUUCUGGACGCC 1646 CUGCCCUGGGGUAAGGGGCC AUUCUGGCCUUGGCGGAGUUGGGGAUGGUGUCGCCUAGCAGCCGCUGCCGCUUUGGCUUG CUCGGGACCAUUUGGCUGGACCCAGAGUCCGCGUGGAACCGCGAUAGGGAUCUGUCAGGG CCCGCGGCCGGGUCCAGCUUGGUGGUUGCGGUAGUGAGAGGCCUCCGCUGGUUGCCAGGC 1647 UUGGUCUAG AGGGAGACGUGGUGGGCGGUCCUUCCUGUGACACGACCCUUGAGUGACAGUUCUAUUUGA UUGCCUCCGGUACUGUGAGGAAAGGACACGACUCU 1648 AGGUGUCAUGGCUGCCCCAAGAGUCUAGGUAAGAGUUUGUUCCCGUGGUGCGGAGGGUCA AGGCCCACACCCGGAAACCUAGCGAGGUAAAGUUGCGUCUUGGUUGUAGAGACGACAACU 1649 UCUCCGCUUCCUCGGCG AACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1650 GGAGAAGGGAGGUGACUCCGGCGGAAGAGGACAAGGCAGA 1651 UUCUUUUCCUCUCUUCUUCUUUCGCGGUUCAGC 1652 UUCUCUAGUAGGGUGAUGAUAUAAAAAGCCACCGGAGCACUCCAUAAGGCACAAACUUUC AGAGAC AGC AGAGC AC AC AAGC UUC UAGGAC AAGAGC C AGGAAGAAAC C ACC GGAAGGAA 1653 CCAUCUCACUGUGUGUAAAC GGCGGCCGCGCGGAGGAGGCCAAG 1654 AU C UAUC AUC C C AC UAC C AC C 1655 ACAUGUCAAAGAGACACACACUAAAUUAGCAGGGAGUGUUAUAAAAACUUUGGAGUGCAA GCUCACAGCUGUCUUAAUAAGAAGAGAAGGCUUCA 1656 GUUUACUCUUACUGUUCUAUCUCCAGCACUGCCCGUCUCUGCCUCUCUCCACUGUCCCUG GAGCUCCCUGGGCCCUUCCCUGGGCCUCAGGACCUCACUCACCACCCCAUCUGCCCUGCA 1657 GG ACUCCGGCUCGGCGGCUCUGGGCCUGCGGCGGGCGCUGCGGGUUGGAGCUCGGGACGUGA UCGUGG 1658 AGCCGUGGUCGCGCUGUGUGUGUGUGUGAGUGGAGAGUGAGUGCGGGACCUGAGGCUGUG UGUGUGUGAACUGUGGCCACUGGCGGGGUCGGGGGGGGGCAGCGGCGGAGCCGCCUCGGA 1659 CG AUAGUAGUUGGGGAGUCAGACAGUCCAUCCACCUGCUGCUGUGAGGGAGUGAGAAGUGAA GAGGAAGCAAGCUGGUGGAGGAGACAGAGGACCCCGAGGUUAGGGCUGCUGUUUUACCAG AGCUGACCGAGCCUGAGGAGCUGGCCUCAGAGCAGAGGCCUGGAUGAAGCGAGGAGCAGC 1660 GUGGCUCGUUGG AGACUUGCUGGUCUGAUCC 1661 AGAUGCAGAGGACUUAGACAUCAGGAAGACUUAGCCACUGGAGGCAGUACUUCAGGAAAG UGCACUCUUUGAUCAGUGGUCUUUCCUCGGCCCUGCUCUGAAACCUAACCAG 1662 AGGCAGGGGAAGGAUCCGGCAAAAAAGGCACACGGUUCAGGCCUGUCCACUCCAGCCUUG GGAGGAGGUGAGC AGGUCAC C 1663 ACGGGGCUGCCCUCCCCUGCGCACUCCCCUCGCUGCCCGGGCCCGGAGCGCAGCGCGGCC GCACAG 1664 GGUCGGCGUGGUCUUGCGAGUGGAGUGUCCGCUGUGCCCGGGCCUGCACC 1665 AGUUUCUAAGGAUC 1666 AGAGGGAAGGCGGGAGGGCGCGCGCCAGGGUCGCUCGCUCGCUCCCUCCCUCCGCUGGUG CGUUUAGUCAGUCAGCCAGCAGCAGCCGGCGGGCCCGCGAGCCGCAGAGGGCCCGAGCCU CGGACGCCGGCGCCUCCUCCUGCCAUUGUUCGUCGGGCUGCAGCAGUGGCGGGCGCAGGA 1667 GCCCGGCCCCGGAGCCACCG GCGGGCGGCUCCAGACUUCACAGGCAGCAGCUAGCGAGGCGGUCUCGCCCGGCGCGAGGC CGGCGCUGUGCUCGCCUCGGAGAUCGCUGCUCUUUAGCUGGGUGCAGAAGGCGGCUCCGC GGCUCGCGGACGACUGGCUGGGCGCGAAUCAGAUUGGGGGGCUUUCUCCCGGUCCCCUCC 1668CACCUCGUCUGGGCUCGCGGCGUCUCCGGGGAAAGCCGUGGCCCCGAGGGCGGAUCCGAGAttorney Docket No.: 62801.85WO01AUGUCUCUCGAAGAAAGGUUAUAAACCCUGAGAUAUGAGGGUUGGGCGAGACAUCCGAGC CUGUUUCGUUCCGUGUUGGGACCAGGAAUAACCCUGACUUCUGAGCUUUCAUAACCCCAG 1669 GAUCCUCCAGAAAAUUUGCGGCGCGCUGAGGGAAAACCUUGCUG GCCCAGAAAUUCUACCCAAGCUCCCUCAGCACC 1670 AGAGCAGCACCGGCCGUGGCUCCGGUAGCAGCAAGUUCGAACCCCGCUCCCGCUCCGCUU CGGUUCUCGCUCCUUCGGCCCUUGGGCCUCCAAACACCAGUCCCCGGCAGCUCGUUGCGC 1671 AUUGCGCUCUCCCCGCCACCAGG AACAGCCGCCUGUUGAGUCUCCUCCAGAUCGCAGCUGAAGGAUCUGUUGAGCGCUUCAGG AAAGGCGGUGAGAUCCG 1672 AGUAACAGCUUUUGGUUUCCCGACCAGGAACACUUUGGCUCAGUUGCCAUGGGCCAGGAG UCUCACAGAACUACUAAGCAGCUGCUUACCCAAUUUUGGCUGGAGAGAUAAGUACCCUCU GGGGCCACCACAGCUGGCCCCAACCAUGGUCCUGAUUGCCUUGGAAGAACUGCCUUUGGA 1673 AUUUCACAUCGGCAUCCAGAUAG ACGCCGGCUCCGCGCUCCAGGGGCUGCUGAGCGCCCAGCGGACACCGGCAGCGCGCGGUC GACGCGGGCCUGAGCUCCCUCCAG 1674 GCAGUCGCUGCAGCCGCCGCGGGAGGCGUCCGU 1675 AUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1676 AUCUCUUUCAAGGUUUCUGCUGGGUUUCUGAACUGCUGGGUUUCUGCUUGCUCCUCUGGAG 1677 GAGAACCAUCCCAGUAACCCGACCGCCGCUGGUCUUCGCUGGACACC 1678 UCCUUCAGAGCUUACAUCAUGUGGCCGAGUUUAUAUACCUGAUUGGCAAAACAGAGCCUA AGAACCAGCUCUCCUGUAUCCCAAGCAAGGCUCUUUCUACCGCACACCCUGCAGGCCCAU 1679 CCAGGCCCAUCCAGACAAUAAACA AGAAGC C UC C UGGC AGAC AC UGGAGC C AC G 1680 AC UUGGGAAC GAGGGGUGAAGCGGCC CAGGUGAGG 1681 GGACUUCCUAGUGGGUGUGAAAGGCAGCGGUGGCCACAGAGGCGGCGGAGAG 1682 GCAUUCUGAACUUCAGCACAAGGCAAACGCAGAACCAGGGCUUGGAAUUUCGCCGCUAUG CAGCUGCACCCCUGCCACCCAGGAGAUCUGAGGCUCCUCAGAGCUGGGAGGACCGG 1683 UAUAACGUGAGGGCUGAAUGCAGCCCAUUCUCUGGAGAACUUCCUCACACACCGCAGCAA AGAGAAGACUGAAAGACAAACCUGGGUGCAGCCAGAGAGGUCCAGAUAGAUGAGCUUGUG 1684 GCAUCCAUUCCCCAAGUUCAG GAACGUCCCGCAGGGGUGGUGUGCUCUUCUCUAAAAACAUUUUUUUUUUUAAUUUUGUAU AUUUUUCCGCCAGAAGCAGUCAGUUCCCUGCACCCAGCACCUCACAGCCCUUCCUCCGUG 1685 CGCCCUGCCGGGCGGCGAGCUAGGCGGCAGCGGCGCGGCGCGGGCUCGGCGGAGCGGCCC GCUGGUGACGUAGUGAGUGUGAUGGCCGCCGCGAGGCCGGGAAGGUGAAG 1686 GUCAUUUCCGGCUCGAAUGCCCGGCAGCCGUGGCGGCUAGAGCGUUCCUCCCCAGCUCGA AUGCCCGGCGGCCGAGGCGGCUAGAGCGUCGCCUCCUCCCGGGGAACCGCGUGUGACCUU 1687 CCAGCCCGCGGACCG ACCACGCCUCCUCCAAGUCCCAGCGAACCCGCGUGCAACCUGUCCCGACUCUAGCCGCCU CUUCAGCUCGCC 1688 GCCCCUGCCCUGAGGACCCUAGUCCAAC 1689 CGGGGCGGAGCGGCUCGAGCAGCGGCGGGCUGGCAGGCGGUCGUCCGGCCGGGGACCCGG CCCGGGACCGGCGGCGCGCGGCGGCCGAGGCCAG 1690 AGCCCUCCUCCAUGUCCAGCUGAGGGAAGGCUCGUUUCAGUGCCGCGGCCGGCGCCCGCC AAGGGAUGGGCAGCCAGAGCCUGUCGACUGCGGCUGCGCAG 1691 UUCGUAGCCCACUGAGCUUCCUCACGCCGGCUGUCGCAGCGCCUAGCCCCACCCGGCGGC CUCUCCUGCGCUUCCGGGGCCGUGGCGAGCUAGUGCGCCUGCGUGCCGGCCCAUCCGCGC GCCUUGCAGCUGUCCUUGCGUCGGCCAGCGGCCAGACAGUUCCUGCAGCGCUUACCGCCU 1692 GGCCUCUCGGUUCCGCGGCGCACCGGAGGGCAGC GAGACCCUGCAGCACCAUCUGUC 1693 AGGCUCUGUGGUAGGUGAACCUCGGCGGCCGGCGUGGGCUGAGGGAGCCGCCACUGAGGG UGCGGGCGCCGCGGCCGGCUCUGCCAGCCGUUCUCUGGAGCAGCGAGGCGGUUGGUUGUG 1694CGAGCGAGUGCCGAGGACUUUGGCUGGAAACUUUUCGCCGCGCCCGGGGCGAGGCCCUGGAttorney Docket No.: 62801.85WO01AAGGGCCAGGCCAGCGAAUGCUGAGCCGGCGGCCCGCUGCCCUCCCCCGCGGCCGCGCGG GUCGCCGUGCGG GUGCUGAGGGGGCGCGGCGCGGAGGGGCGCGGAGCGGCGCGGAGCCGGGCGGCUCGGGGC CCAGAGAGAGCCGCGGCCGGGAGCUCGCGGGCUCCUGACAACCUCCUCCCCUCGGCGGAC GACGACCACGGCGACUAGGGCGCCGGUCAUGGCGGAGCAACAAACCCGGCGCGGACCCUA 1695 GGCACCACCGC AGAGGCCGUGGGGCGGGCCACGGUGACGCGCGCGGAAGCGCUCUGCGGGCCCUCGGAAAC CGCCCCGGCGGCUGAGAGGCUGCGGCCACUGCCUGGCACCCCGACGGGAGGGGCUCCGGA 1696 UCGUUCGGAGCCGGCUGAACCCCUUCGGCCGCGAGCGACCGC GAGGGGCAGGCACAGGAGUCCUGGCUGAGCUCAUGGCCUGAGGCUGCCUAGCGGCCACGG GGA 1697 CGCAGAGCCAGCCCCCGACCCCGGGCCACCUGGGCCCCCGGGUUCCGCCGGCACUCUCGC CACCACCGCGUGG 1698 AGUUCUUUUCUCACCUUGACUGCAAG 1699 GUUCCCUCCUCCCUCGGCAGCCGCGGCGGCAGCAGGAGAAGGCGGCGGCGGCGGCUAGGG AUCAGAC 1700 GGACGGAGCGUAGGAGAGACCGAAAAGGCUGGGGGUGGGAGUAGCGGAUUUGAAGCACUU GUUGGCCUACAGAGGUGUGGCAAGCAGAGCACCUCAGAACUCAGGCGUACUGCCCGCCGC CCGAGCCCUGCGAGGGCCGAUAGCGAGGGUGUGGCCCUUAUCUGCACCCAGCAGAGCGCC 1701 GGCGGGGUACGGUCUUAGGACCUCGAUCUCCUUCUCCCUCAUUUUCUCUCAUCCCUACCU AUUGUGG GCGUCUUGUUCUUGCCUGGUGUCGGUGGUUAGUUUCUGCGACUUGUGUUGGGACUG 1702 GUGCACGCGGUUGUAGCUGCCCGGCGGCGGCAGAAGCGGCGCUCGCGCCAAGGGACGUGU UUCUGCGCUCGCGUGGUC 1703 AGAGAACCUUCCCUGGUGUGGAGGCAGCCAGGGACCCAGG 1704 AGCAGUGAGAGCGGUUGCGCAGUGAAGGCUAGACCCGGUUUACUGGAAUUGCUCUGGCGA UCGAGGGAUCCUAGUACACCGCAAUC 1705 ACUCCGCUCUCGGCGCCUCGGGCUCCGCGCCCGGCCAGCCUGAGGUGGGGUCGGUGCCCC CGGCGGCACGGCGCUGGGGAGGCG 1706 GCCAUUUCAGGGAGCUUGUCGACGCUGUCGCAGGGGUGGAUCCUGAGCUGCCGAAGCCGC CGUCCUGCUCUCCCGCGUGGGCUUCUCUAAUUCCAUUGUUUUUUUUAGAUUCUCUCGGGC CUAGCCGUCCUUGGAACCCGAUAUUCGGGCUGGGCGGUUCCGCGGCCUGGGCCUAGGGGC 1707 UUAACAGUAGCAACAGAAGCGGCGGCGGCGGCAGCAGCAGCAGCAGCAGCAGCAAUCUCU UC C C GAAC AC GAGC ACC AC AGGC GC C C GAAGGC C GGAAC AG GCACGAGAUCUGCGCCUCGCCUCCCUCCUCACGCGGGCGGAUUUUCUUACCUUGUGAAAA ACCGUCUCAGCGGCUGCCCCCGCCUCCUCUGCUGGAUGUGAAAUGGCGGUCGGCGAG 1708 AAAGCCUGCGAGCGCCAGCCGAGAUCGCAGCCCAACCC 1709 CCUUUCCUUUCAGCGGAGCGCGGCGGCAAG 1710 CUUUUCCGUGCUACCUGCAGAGGGGUCCAUACGGCGUUGUUCUGG 1711 AGGUCCGUUAUAUUAUUUAUCUUGCAGAUCAAACUUCAGAGAGGAGGGCC 1712 AGGGACCAAGAGUUCGAUACCUCAUCGAACUGCGAGUCAUAAGCAGGGCC 1713 AGAGAAAGAGUUUCGAGAAAGUUGCGAUACACACCGACCUAAUCCGUGUC 1714 AGCCGCAGAUCGCUGGAUCCUGUCACCGAGCCCUUCGGUGCUACAGGUUA 1715 AGUCCCGUAGUUUGGCCGCACUUCACCGAAAGGGACAUCGCCGAGACACG 1716 AGUUGGACUUGCGGACCACAAGGACAACGCGAGAAGGCAUAGUCCAUAUC 1717 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 1718 AGCGUUUCUAUUUUCGCAGUUUCGGAUCUGCCUUUUCGCGGAUUUAUAUC 1719 AGAGGAGUCGAGUUAUACAGCCGCAACGCUAUCCUCGACGAACACAGGAA 1720 GGUGCUGGCGGCUGCAGCCGGAGUUCAAACCUAAGCAGCUGGAAGGAACC 1721 AGUGGAGAGCGCAAUCCAGUUUCCUUAGCAAAGCAUAUCACCCUUCGGCU 1722 AGGGAACAGUGGAGCACAAUAGUUGUCACAAACGCGUGACCUGUACCUUA 1723 AGUUGACUGCAUACGCCUUGAUUAACUAAAUCGAGCGCCUACCGGAGAGU 1724AGACUGAGUAGCGUUGUCGAUUGCUGUUUUCAUAACCGUACCGAGCCUGC 1725Attorney Docket No.: 62801.85WO01AUUUCUCCACCCAGGUGAACUCCUCCCUCACCUCCCCGACGGGGCGAGGCUCC 1726 GGGCGCUCGAGCAGGUUCAGAAGGAGAUCAAAAACCCCCAAGGAUCAAA 1727 CUGAAACACGGUGGAGAGUUUAUUGCAAAAUAACGCGUCCAUUCGACA 1728 ACGGACUGCUAAAGGUCUCCCCUCCCACCUGCAUUGCUCUACAAUCUGUGGCCUCAGCCC UUGCCAACUCUGCCUCUUCCCCCGCUGACUGGG 1729 AUCCCCUCUUCUCCUCAGGAACUGCUCAAACCUGUGCCCCAAAG 1730 CGCAACCUUUCCAAGGGAGUGGUUGUGUGAUCGCCAUCUUAGGGA 1731 ACUCCACAGCUGCUGCUCCUAGGGAGGAGCUGGUACC 1732 GCCCCCUCCCGGGGCUGGAGGGGGGCAAGCGGGUUCCGAGGUGCAAAGCCUGGUGCCCCG AGCCCUGCGGA 1733 AGAGUCACUCCUGCCUUCACC 1734 GUUAUCCUGAAUACAUGUCUAACAAUUUUCCUUGCAACGUUAGCUGUUGUUUUUCACUGU UUCCAAAGGAUCAAAAUUGCUUCAGAAAUUGGAGACAUAUUUGAUUUAAAAGGAAAAACU 1735 UGAACAA AGCUGCCGCGGUCGCUCCGAGCGGCGGGCCGCAGAG 1736 GGCGGAAGUAGUGUAACCAGCUGGGAGCCAGCCGGCAGGACGCUGUGAGUUGGCGUGCUA GUGGG 1737 GUCUAAGAGGCAGACAGAUACAUUGUUCUUCACUGGUCAGCUGAAAGUCAAUUCAUCAUC AGUGAUAUUCAAAAAUCACAAGUCUUUGCUGGC 1738 CCCGCGACGGUAGGGGACUUCCAGGGCGAGGGGGCCCAUCUGCCCUCGGGCGCCAGGAGG 1739 GUCGGGUGGGAAGCCGUGUCUCGCAGUCGUGGACUCGUGCAGCUGGGGCGUCCGCAGCCG CUCGUCACCCGCGUG 1740 CUGCGGCUGGGGCUGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGG UCCGGCGGGUUCAAAGAGGAAAAC 1741 AGUGCGUUACUUACCUCGACUCUUAGCUUGUCGGGGACGGUAACCGGGACCCGGUGUCUG CUCCUGUCGCCUUCGCCUCCUAAUCCCUAGCCACU 1742 GUCGUUGGGCGUGCGCAGCUGCAGCGGCGGUUGAGGUCAAGUAGUAGCGUUGGGCUGCGG CAGCGGAGGAGCUCAAC 1743 GCUGCCUGGGUCCCGGGACGUGGGGGCCCCGCGCCCCGCUGCCCUUGCUUCCGCGAUCUC UCUCUUCUGAAUACGUUUCCGCUCGUUUAUCUCUGCGAAGUGAUUUUACUCUG 1744 GGCGAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 1745 GGGUUCGUUCGCUUCGCGUUUUGGCCAGGGCGGGGGUCUGGGCUUUAGGCA 1746 GCGCGAGCCGCGCCGGCCCCGGUCGGGCCUCCGAAACC 1747 CUUUCCAGCCUCACGCCCGUGGGCUGCAGUUGGAACG 1748 AGGUGCCGCUUCCUGUCCCCUUCUCCGCGCUGCCUCACGGUGCCUGCACGGGACGCCGCU CGAUCCCCGAGCCCCCUCGCCGUCCCCGACAGCCCCCCCGGCGCC 1749 GGGCGGGGGCGCGGCGAGGCGCCGGCGGCCGUGACGAGGCGCUCCCGGAGCUGAGCGCUU CUGCUCUGGGCACGCAUGGCGCCCGCACACGGAGUCUGACCUGAUGCAGACGCAAGGGGG 1750 UUAAU CACUCGCGCUGCCAUCACUCUUCCGCCGUCUUCGCCGCCAUCCUCGGCGCGACUCGCUUC UUUCGGUUCUACCAGGUAGAGUCCGCCGCCAUCCUCCACC 1751 CUUGUCUCGCUCCGGGGAACGCUCGGAAACUCCCGGCCGCCGCCACCCGCGUCUGUUCUG UUACACAAGGGAAGAAAAGCCGCUGCCGCACUCCGAGUGUCAACAACACUCGCGCUGCCA UCACUCUUCCGCCGUCUUCGCCGCCAUCCUCGGCGCGACUCGCUUCUUUCGGUUCUACCA 1752 GGUAGAGUCCGCCGCCAUCCUCCACC CAUUCUGUGGUCUGAUCAUCCUGUGGUUUCGUCGCCGCCAUCCUCGUCGCGACACGCUGU UUUCGGUUCUCGGCCCGACGAGCCAUCGCCAUCCUACAGCCAACAACACUCGCGCUGCCA UCACUCUUCCGCCGUCUUCGCCGCCAUCCUCGGCGCGACUCGCUUCUUUCGGUUCUACCA 1753 GGUAGAGUCCGCCGCCAUCCUCCACC CUUGUCUCGCUCCGGGGAACGCUCGGAAACUCCCGGCCGCCGCCACCCGCGUCUGUUCUG UUACACAAGGGAAGAAAAGCCGCUGCCGCACUCCGAGUGUCAACAACAUUCUGUGGUCUG AUCAUCCUGUGGUUUCGUCGCCGCCAUCCUCGUCGCGACACGCUGUUUUCGGUUCUCGGC 1754CCGACGAGCCAUCGCCAUCCUACAGCAttorney Docket No.: 62801.85WO01CACUCGCGCUGCCAUCACUCUUCCGCCGUCUUCGCCGCCAUCCUCGGCGCGACUCGCUUC UUUCGGUUCUACCAGGUAGAGUCCGCCGCCAUCCUCCACCCAACAACAUUCUGUGGUCUG AUCAUCCUGUGGUUUCGUCGCCGCCAUCCUCGUCGCGACACGCUGUUUUCGGUUCUCGGC 1755 CCGACGAGCCAUCGCCAUCCUACAGC CAUUCUGUGGUCUGAUCAUCCUGUGGUUUCGUCGCCGCCAUCCUCGUCGCGACACGCUGU UUUCGGUUCUCGGCCCGACGAGCCAUCGCCAUCCUACAGC 1756 CUUGUCUCGCUCCGGGGAACGCUCGGAAACUCCCGGCCGCCGCCACCCGCGUCUGUUCUG UUACACAAGGGAAGAAAAGCCGCUGCCGCACUCCGAGUGU 1757 CACUCGCGCUGCCAUCACUCUUCCGCCGUCUUCGCCGCCAUCCUCGGCGCGACUCGCUUC UUUCGGUUCUACCAGGUAGAGUCCGCCGCCAUCCUCCACCCAACAACUUGUCUCGCUCCG GGGAACGCUCGGAAACUCCCGGCCGCCGCCACCCGCGUCUGUUCUGUUACACAAGGGAAG 1758 AAAAGCCGCUGCCGCACUCCGAGUGU CAUUCUGUGGUCUGAUCAUCCUGUGGUUUCGUCGCCGCCAUCCUCGUCGCGACACGCUGU UUUCGGUUCUCGGCCCGACGAGCCAUCGCCAUCCUACAGCCAACAACUUGUCUCGCUCCG GGGAACGCUCGGAAACUCCCGGCCGCCGCCACCCGCGUCUGUUCUGUUACACAAGGGAAG 1759 AAAAGCCGCUGCCGCACUCCGAGUGU GACGCCACGGACAUGGUGGCCGAGACCGGCGGGGUGGGGGACGUGUCGCGCGGCCGGGUG GCCUCGGUCGGUACCCUGGGCGCGGAGCAGCUGCCUCAUUAGUAUUCGUACCCACGAGGC 1760 GGCGCAGCGGGCCCUCGGGGACAGCGAGCGUCGCGGCC AACCUUGAUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1761 AACCAUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1762 AAUCUUGUUUCCUUUUUUAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1763 AACCUUGUUUCCUUUUUAAAAAUCCCAAACCUCAUCCUGCCUGCCAAGAC 1764 AAGCAUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1765 AAACUUGUUUCCUUUUUAAAAAUCCCACAUCUCUUCCUACCUGCAAAGAC 1766 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCGAAGAC 1767 AAUCAUGUUUGCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1768 AGCCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCGACGAC 1769 AACCUUGUUUCCUUUUUAAAAAUCCCAAACCUCUUCCUACCUGCGAAGAC 1770 AAACUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUACCUGCCAAGAC 1771 AACCAUGUUUCCUUUUUAAAAAUCGCACACCUCAUCCUACCUGCAAAGAC 1772 AAACUUGUUUCCUUUUUUAAAAUCCCACACCUCAUCCUACCUGCGAAGAC 1773 AACCUUGUUUGCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1774 AGGCUUAUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1775 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACGUGCGAAGAC 1776 AACCAUGUGUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1777 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCCAAGAC 1778 AACCAUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGAAAAGAC 1779 AAUCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1780 AACCAUGUUUCCUUUUCAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1781 AAUCAUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1782 AGUCUUGUUUCCUUUUUUAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1783 AAACUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUGCCUGCAAAAAC 1784 AAUCUUCUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1785 AAUCUUGUUUCCUUUUUAAAAAUCGCACACCUCAUCCUACCUGCAAAGAC 1786 AGACGAAGGACGCAUGCGUUUGGUGAGUCCCGGAUUCUGGUGGGUUCUUC 1787 AAGCAGGAGAUGGGCUCAGCAGCAGCCAAUAGGACAUGAUCCAGGAAGAG 1788 GGUCAGGAAUAACAGUUUCAUUAUCUGAGCAACUGGACAUAGAGGCUGGC 1789 UUUGUAAUGUGCCAGUUGCUUAAACUCCCCCUCUUCCUGUCAUCUUCCUA 1790 AGGAAUACCUGCAAUUUAAGAAACUGCAAACGCACGAAACUACAUAACUG 1791GUUUACAUGUUCCAAUAUGAUUCCACCCAUGGCAAAUUCCAUGGCACCGU 1792Attorney Docket No.: 62801.85WO01UUGAUCGGAUGGUGGUUCCCAUCCAGAUCCAAGUCCUGGCCCCUGAUCAC 1793 AGGCUCCAGUGACCCUUCCAUCUCAGCCUCCCAAGUAGCUGGGACCACAG 1794 AGUUGUCAGCCGUUGUUUUUUCGUGCUCGCUAGUCGCCGCCGCCGCUCCG 1795 GGGAUUCUCACAACUUCCAUUUCUGGUGAACAGCUGAGGUCAGAGAGGAG 1796 GACCGCGGCGGUUUGUUCUCAGGCCCCGGCCUUUCUCACCGUGCGACGCC 1797 AGGAAAAAAGAAUCAUUUGCAGCCAGAAAGACCUGACUCGAUUAUUUGAU 1798 AAUAACAAUAGCUGCUCUUUAUUGAGUGUCUACUAUGUAUGAGAUACAAC 1799 AGGAUGACUUUAUUCUUCAGGCCAAUAAGGCAACAGGAGAGGAAGAGGGA 1800 AGGUUCAAGCGAUUCUCCUGCCUCAGCCUCUCGAGUAGCUGGAAUUACAG 1801 AAAUAGACAUACUGAAUAAAAGUUUGACAGUAUCCCAGAGAAAUAAAGUA 1802 GGACGGUUUGCUGAGCCCGUUAGUGCGCCCGGCCGAGACACGCCGCCGCC 1803 GUUUAUACCCACCAGGACAAGAGCCCAUACCCAAGAUCUCAGAGUCAAAG 1804 GGGCUGCUCUAGAGGACUCAGGCCCCGAAGCUGUCCCAGGGAGGUCCCCG 1805 AUUCUCUCUUCAUUUUGUCAGCAAACAGCUCACUGUCCUCUGGAUCUGCU 1806 AAUCAAGCACUCUUUUGGAAGAGGGUAAUCUCUCUCCAAAAACUGAGGAC 1807 GUUUGUGGCUGCAUUUUUAUCUCUGGUGGCUCUGCUACGGCGGCGCAGAA 1808 CUUUGUGUGUCCUGCUCACAUUGUCUCCAGGGCCUCGGACAGGGCCUGGU 1809 AUGAAUCCUCAGCUCUGGGCCCAGUGGAGGCGCUGGGGACGGAAGAAGGG 1810 AACACGCCAGGAUCUUUCCAGUGUCAGUGCCUCUCUGGCUACCAUCUGUC 1811 AGCCUGCAUUGGGGGUGACUGCAUCAAUACCAAUGGCUCCUACAGAUGUC 1812 CUUUAAGACUACUUCUGAUUUGCAAAGAUUGUCUGUGCUCUGAGCAGGCU 1813 UGGAGAAAUUUCUUUUUGUCAGUUUGGAUUUAAUUUUAAGAAAUAAUGAG 1814 GAAUCCUGCUUUUUUUUUUUCUUUGAGACACGGUCUCACUCUGUCACCCU 1815 UCGUGGCAUUCCUGGUGGCUUUCCAUCAGAACAAGCAGCUCAUCGGUGAC 1816 UCCUGAAGAACUUCCAGCAGUACUUCCAGGACAGGACGAGCUGGGAAGUC 1817 GAAGGUGAAAUUCUGUGUGCUCCCUCCGGCGAGAGACUUUGUCAGCUCCC 1818 AGGUAAACAUUACAGUACAGAAGAAAGUGAGUCAGUGGUGGGAGAGACUC 1819 GGACACGGCCCCCGCCCUGUUCGCCCCGCGCCACCGGCCCGCGCCCCGCC 1820 AUCUGGGCAGCAAGGUGGAAGGGUGGCCAGGGCAUCAGCUGGAUGAAAAC 1821 UAGUGUCGUUCAUUUCUUAAUUCCCUCCUCUUCAGGCUACGACUGGCAAA 1822 AGGUUCAAGUGAUUCUCCCACCUCAGCCUCCCAGGUAGCUGGGAUUACAG 1823 GGGCUCAAGCGAUCCUCCCAUCUCAGCCUCCCAAGUAGCUGGGACUACAG 1824 AAGGGAAGGGUCACGCGCUCGGUGUGCCGAGAGUGUCCUGCCUGGUCCUC 1825 ACUUUUACAUUUUUGUCUUCAUUGCUUAACAUCGUUUUUAAGAAUUCAAA 1826 AAUCUGAACUGCCUUUCUCUGAUCACACACCUCAACCGACGGACCAAAUA 1827 AACCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1828 AAUCUUAACUGCUUUUCUCUGAUCACACACCUCAACCGGCGGACCAAAUA 1829 AACCUUGUUUACUAUUCUCUGAUCGCACACCUCAACCUGCAGACAAAAUA 1830 AACUUGAACUGCUUUUCUCUGUUCACACACCUCAACCUACGGACAAAAUA 1831 AACCCUGAUUCCUUGUCAAAAAUCCCAUACCUCAUCCUGCCUGCAACGAC 1832 AACCCUGAUUCCUUGUCUAAAAUCCCAUACCUCAUCCUGCCUGCAACGAC 1833 AACCCUGAUUCCUUGUCUAAAAUCCCAUACCUCAUCCUGCCUGCUACGAC 1834 AACCUUGAUUCCCUUUUUCCAAUCGCACACCUCAACCUACUUGCUAAAAU 1835 AACCCUGAUUCCUUGUCUAAAAUCCCAUACCUCAUCCUGCGUGCAACGAC 1836 AACCUUGAUCACUUUUCUCAGAUCACAUACCUCAUCCCGCGGACCAAAUA 1837 AACCUUGAUUACUUUUCUCUGAUCGCACACCUCAACCUACGGACCAAAUA 1838 AACCUGGAUUGCUUUUUAAAAAUCCCAUACCUCAUCCUACCUGCUAAGAC 1839 AACCUGGAUUGCUUUUUAAAAAUCCCAUACCUCAUCCUACCUACUAAGAC 1840AACCUUGUUUCCUUUUUAAAAAUCCCACACCACAUCCUACCUGCAAAAAC 1841Attorney Docket No.: 62801.85WO01AAUCUUGAUUGCCUUUCUCUAAUCGCACACCUCAUCCUGCUGACUAAAUA 1842 AACCUCGUUUACUUUUUAAAAAUCACACACCUCACCCUGCUUGUCAAAUC 1843 AACCUGGUUUGCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1844 AACCUCUUUUCCUUUUCAAAAAUCGGACAACUCAUCCUACGGACCAAAUC 1845 AACCUGGAUUGCCUUUUAAAAAUCACAUACCUCAUCCUACCUACUAAGAC 1846 AAUCCAAAUUACUUUUUUCUAAUCACACACCUCAUCCCGCUGACUAAAUA 1847 AAUCUGGUUUCCUUUUCAUCGAUCACACACCUCACCCCACUUGCUACGAC 1848 AAUCUAACUUACCUGUUUCAGAUCACACACCUCACUCUGCGGACUACAAC 1849 AACCGAACUUACCUUUUUCAGAUCACACACCUCAACCUGCGGACUACGAA 1850 AAUCCGAACUACCUUUUUCAAAUCACACACCUCACCCUGCUGACUAAAUA 1851 AAUCCGAACUGCUUUUUUCAAAUCACACACCUCAUCCUGCUGACUAAAUA 1852 AAUCUGAACUGCUUUUUUCAAAUCACACACCUCAUCCUGCUGACUAAAUA 1853 AAUCUGAACUACUUUUCUCAGAUCACACACCUCAUCCUGCUGACCAAAUA 1854 AAUCUUUUUUACUUUUCUCUGAUCACACACCUCAACCUGCGGACCAAAUA 1855 AAUCGGGAUUACCUGUAUCUGAUCCACCACAACAACCCACGAAUUCAGUA 1856 AAUCGGGAUUACCUGUAUCUGUUCCACCACAACAACCCACGAAUUCAGUA 1857 AACCCUGAUUCCUUGUCUAAAAUCCCAUACCUCAUCCUACGUGAUACGAC 1858 AACCUGAGUCACUUUUUUCUGAUCACACACCUCAUUCGGCGGAUGAAAAC 1859 AAUCCAAGUUACUUCUAACAAUUUCCACAUACCAUCCUACCGGCAAAAUC 1860 AACCCGGAUUCCCUUUUAAAAAUCACAUACCUCAUCCUACCUACUAAGAC 1861 AAUCUAUUCUACUUUUUUCUAAUCGCACACCACAUCCUACGGACCAAAUA 1862 AAUCUAUACUACUUUUUUCUAAUCGCACACUGCAUCCUGCGGAUGAAAUA 1863 AACCUCUUUUGAUUUUUAAAAAUCCCACACCUCAUCAUGCCUGCUAAGAC 1864 AACCUUGUUUACCUUCUUAAAAUCACACACCUCAUCCUACCUGCUAAGAC 1865 AACCUCGUUUACUUUUUUAAGAUCACACACCUCAACCUACUUGUGAAAUA 1866 AAUCAAACUUGCUUUCUAAAGAUCACACACCUCAUCGCACUAAUUAAAUA 1867 AACCGAAGCAGCUUUUCCCAGAUCAGACACAACAUCGCACUAAUUAAAUA 1868 AACCUGACUUGCUUUUUUAAAACCCCACACCUCAUCCUACCUGCUAUGAU 1869 AACCAGAACUACCUUUUUCAGAUCGCACACCUCAACCGACUGACCAAAUA 1870 AAUCAGAACGACCUUUCUCUGAUCACACACCUCACCCUGCUGACUACAUA 1871 AAUCUAAACUACUUUUUUCUGAUCACACACCUCAUCCUACGGACGAGAUA 1872 AACCUUGAUUACUUUUCUUCGAUCACAUACCUCAACCUACCUGCUAAACU 1873 AACCUUGUUUCCUUUUUUCAAAUCCCACACCUCAUCCUACCUGCUAAAAC 1874 AAUCUUGGGUACCUUUUUCUGAUCACACACAUCAACCUGCCUGCUAAAUA 1875 AAUCGAACCUUCCUUUCACAAAUCACACACCACAUACUACCUGCGAAACU 1876 AAC C C AAAC UGAC UGC UAAAGUUC AC AC AC AC C AUC UAC GAGAAUAC GAC 1877 AAC C C AAAC UGAC UGC UAAAGUUC AC AC AC AC C AUC UAC GAGAAUAAGAC 1878 AAUCUAUGUCACCUUCUUCUGAUCACAUACCUCAUCCUGCUGACCGAAUA 1879 AAUCUAUGUCACCUUCUUCUGAUCACAUACCUCAUCCUGCUGACUGAAUA 1880 AACCUAUGUCACCUUCUUCUGAUCACAUACCUCAUCCUGCUGACUGAAUA 1881 AAUCUAUGUCACUUUCUUCUGAUCACAUACCUCAUCCUGCUGACUGAAUA 1882 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGAAAAGAC 1883 AACCUCGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAACGAC 1884 AACCUUAAUUACCUUUCUUCGAUCACACACCUCAACCUACCUGCGAAACU 1885 AAUCUAUUUCACUUUUCUAAGAUCACACACCUCAACCCGCGGACCAAAUA 1886 AAUCUAUGUCACUUUCUUCUGAUCACAUACCUCAUCCUGCUGACCGAAUA 1887 AAUCUAAAUUACCGUUUUCAGAUCACACACCUCAACCUGCUGACUAAAUA 1888 AACCUUGUUUCCUUUUUUAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1889AAUCUAUUUCACUUGUCUAAAAUCACACACCUCAACUCACGGACCAAAUA 1890Attorney Docket No.: 62801.85WO01AACCUUGAUUACUUUUGAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 1891 AACCUUGUUUACUUUUUAUUGAUCACACACCUCACCCUACUUGCUAAGAC 1892 AACCUAGUUUACCUUUUAAAAAUCCCAUACCUCAUCCUACCUGAAAAGAC 1893 AAUCCAACCUGCUUUCUUCUGAUCACAUACCUCACUCUACGAACUAAAUA 1894 AAUCCAACGUACUUUCUUCAGAUCACACACCUCAUCCUACGGACUAAAUA 1895 AACCUUGAUUCCCUUUAAAAAAUCUCAUACCUCAUCCUACCUGCAAAGAC 1896 AAUCUGAACUGACUUUUUCAGAUCACACACACCAUCCCGCGGACCAAAUA 1897 AAUCAGAACUGACUUUUUCUGAUCACACACACCAUCCCGCGGACUAAAUA 1898 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAAAC 1899 AACCUGGAUUGCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCGAAGAC 1900 AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCC 1901 AGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCC 1902 AGGAGAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCC 1903 AGUCAGGAAGGACGUUGGUGUUGAGGUUAGCAUACGUAUCAAGGACAGUA 1904 AGACUUGUUUCCUUUUUCAAAAGCCCACAUCUCAUCCUACCUGAAAAGAC 1905 AGACUUGUUUCCUUUUUCAAAAUCCCACAUCUCAUCCUACCUGAAAAGAC 1906 AGGUGAAUCCCAUUUUUCACCAGCAGUGGUCACAGCGGCAAAGAGCGGCC 1907 AGGUGAAUCCGAUUUUUCAACAGCAGUCGUCACAGCGGCAAAGAGCGGAC 1908 AGGUGAAUCCGAUUUUUCAACAGCUGUCGUCACAGCGGCAAAGAGCGGAC 1909 AACCUUGUUUCUUUUUUAAACAUCCCACACCUCAUCCUACCUGCAAAGAC 1910 AACCUUGUUUGCUUAUUAAAAAUCCCACACCUCAUCCUACGUGGAAAGAC 1911 AACCUUGUUUGCUUUUUAAAAAUACUACACCUCCUCCUACCUGCAAAGAC 1912 AACCUUGUUUCCUUAUUAAAAGUCCCACACCUCAUCGUACGUGCAAAGAC 1913 AGCCUUGUUUCCUUUAUAAAAAUCCCACAUUUCAUCCUACCUGCAAAGAC 1914 AGCCUUGUUUCCUUUAUAAAAAUACGACGUUUGAUCCUACCUGCAACGAC 1915 AGCCUUGUUUCCUUAUUAAACGUCCCACACCUCAUCGUACGUGGAAAGAC 1916 AGCCUUGUUUGCUUUUUAAAAAUCCCACAUUACAUCCUACUUGCAAAGAC 1917 AGGCUUGUUUCUUUAUUAAACAUCCUACAUUUCCUCCUACCUGCAAAGAC 1918 GGCCUUGUUUCCUUAUUAAAAUUCCCACACUUCCUCGUACUUGCAGAGAC 1919 AGGCUUGUUUCUUUUUUAAACUUACUACACUACAUCCUACUUGGAAUGAC 1920 GGCCUUGUUUCCUUUAUAAACUUCCGACACUGGACCGUACGUGCAAUGAC 1921 AGCCUUGUUUGCUUUAUAAACAUACGACGUUUGAUCCUACCUGCAACGAC 1922 AGCCUUGUUUGCUUAUUACACCUACCACACCACACCGUAUGUGGAAUGAC 1923 GACCUUGUUUCUUAUUUCAACUUCCGACAUCUCCUCAGUCCUGCAGAGAC 1924 AGGUUGGUUUGUUAAUCUAACUUACGACCUUAUCUCACUUAGUGACUACU 1925 AGGUUGGUUUGUUAACUACACUUACGACCUUAUCUCACUUAGGGAGUGCU 1926 AGGUUGGUUUGUUAAAUACACUUACGACCUUAUCUCACUUAGGGAGUGCU 1927 AGGUUGGUUUGCUUAAUCAACUUACGACCUAUACCGUCUUAGUGAGUGCU 1928 AGGUUGGUUUGCUUAAUCACCUUACUACGUAUACUCACUUAGGGAGUGCU 1929 AGACGAGUUGACUUUUACAACCGCAACGCUCUCAUCCACGCAGACAGGAC 1930 AGACUAGUUGACUUAUUCAACCGCAACCCUCUCAUCCACGCAGACAGGAC 1931 AACCAGGUUUCCUUUUUAAAAUUCCCACACCUCGUCCUACCCGCAAAGAC 1932 CACCUUGUUUCCUUAUUAAAAAUCCCACCCCCCAUCCUACCUGCAUAGAC 1933 UACCUUGUAUCCUUUUUAAAAGUCCCACGCCUCAUCCUAUCUGCAAAGAC 1934 AGACUGAGAAGCGUUGUCCAUUGCUCUUUUCAUAACCGUAGUGAGCCUGC 1935 UGACUGAGUAGCGUAGCCGCUUGCUGUAUUCAUAACCGUACCGAGCCUGC 1936 AGACUGAGUAGCGUUGUCGAUUGCUGUUUACAUAACGGUACCGAGAGGGC 1937 AGAGGGGUCCAGUUAUGCAGCCGCAACGGUAUCCUCGAAGAACACAGGAA 1938AGAGGAGUC GAGUAAUAC AGAC UC AAC GC UAUC C C C UAC GAAC AC AGGAA 1939Attorney Docket No.: 62801.85WO01AGAGGAUUCAAGUUUUACAGCAGCAACGCUAUCCUCGACGAACACGGGAA 1940 AGACUGCGUAGCGUUGUCUAUUGCUGUUUUCAGAUCCGUACCGAGCCUGG 1941 AGACUGAGUAGCGUUGUUGAUUGCUGUUUUCAGAAACGUUCCGAACCUGC 1942 ACACUUAGUAGCCCUGUCGAUUGCUGUUUUCAUAACCGUACCAAGCCUGC 1943 AACCUUGUUUCCGUUUUAUAAAUCCCACGCCUCACCCUACCUGCAAAGAG 1944 AACCAUGUUUCCUUUGUAAAAAUUCCACACCUCAUUCUACCUGCAAAGCC 1945 AACCUUGUCUCCUUUUUCAAAAUCCCACACCUCCUCCUACGUGCCAAGAC 1946 AGGAGUGUUCACUUAUUCAACUGCUCCCACCUCAUCCAAACAGAAAGGAC 1947 AGAAGC GUC GAGC UAUAC AGC C GC AAUGC UAUC C UC GAC GGAC AC AGGAA 1948 CGAGGGGUCGAGUUAUACAGCAGCAACGGUAUCCUCGACGAACACAGGUA 1949 GGAUGAGUCGUGUUAUACAGCCGCAACGCUAUCAUCGACGAACACCGGAA 1950 AGAGCAGUCGAGUUAUACAGCCGCAACGCUCUCUUCGCCGAACACCGGAA 1951 AGAGGC GUC GAGUUAUAAAGC CGCAACGAUUUCCUC GAC GAAAAC AGGAA 1952 AGAGGAGUCGAGUUAUACAGCCGCAGAGCUAUCCUCGAAGAACAGAAGAA 1953 AGGAGAAGAAACUAGUUUUCUUCUGGUGGCCACAGAGUCAGAGAGAACCC 1954 AGGAGAAAAAGCUAGUAUUCUUCCGGUCGCCACAGACUUAGAGAGAACCC 1955 AUGAGAAUAGUCUAGUAUUCUUCUGGUCCCCACAGACUAAGAGAGAACAC 1956 AGAGGAUUCAAGUCAUACAGCAGCAACGCUAUCCUCGACGAAUACAGGAA 1957 AGGCGUGUUUACUUAUUCAAAUUCCCACACCUCAUCCAACAAGCAACGAC 1958 AGAGGAGUCGAGCUAUACAGCCGCAACUCAAUCCCCGACGAACACGGGAA 1959 AGAGGAGGC GC GUUUUAC UGC C GC AAC GC UAUC C UC GAC UAAC AC AGGAA 1960 AGACUGAGUAGCGCUGCCGAUUGCUGUUUUCUUAACCGGACCGAGCCUGU 1961 AGACUUAGUAGCGUUGUCGAUUGCUGUUAGAAUAACCGGACCGAGCCUGC 1962 AGACUGAGUAGCGUUGUCGAUUGCUGUUUUUGUAUCCGUACCGGGCCGGC 1963 AACUUUGUUUCCUUUUUAAAAUUCCCAAACCUCAUCCUACCUGGAAAGAC 1964 AACCUUGUUUCCUUUUUAAAAAUCACACCCCUCAGCCUACCUGCAAAGAC 1965 AGCCUUGUUUCCUUUUUAAAAGUCCCACACCUUAUCCUACCUGCAAUGAC 1966 AGCCUUGUUUUCUUUUUAAAAAUCCCACGCCUCAUCCUACAUGCAAAGAC 1967 AACCUUGUUUCCUUUUUAAAAAUCCCACUCCUCAUCAUACAUGCCAAGAC 1968 AGGCUUGUUUACUUAUUCAAAUUCCCACACCUCAUCCAACAAGCAACGAC 1969 AGCCUUGUUCCCUUUUUUAAAUUCCCAGACCUUAUCCUAUCUGCAAAGAU 1970 AGCCUUGUUAGCUUUUUAAAACUCCCACUCCUCACAGUACCUGCAAGGAC 1971 AUCGUUAUUUCCUUUUUAAAAAACUCACGCCUGAUCCUAGCUGCAACGAC 1972 AGCCUUGUGUUCUUUUUAAAAAUCCCACACCUGAUCGUAGCUGCGAUGAC 1973 AACCUUGUUUGCUGUUUCAAAUUCCCACAUAUCAUGCUAGCUGCAACGAC 1974 AGCCUUGUGAUCUUUUUAAAAAUCGCACGCCUGAGCGUCGAUGCGAUGAC 1975 AGCUUUGUUUGCUUUUUCAAAGUUCCAUUUCUCAUCCUCGGAGCAACGAC 1976 AGCCUUGUUAGAUGUUUUAAACGCCCACUCUUCACAAUACCUGCAAGGAC 1977 AAAUUUGUACGCUAUUUAAAAUUCAGAAACUUGAUCCUAUCAGCAAAGAC 1978 AGACUCGUUUUCUUUUUCAAAUACUCAGUCCUCACCCUAGAUGCAAUGAC 1979 AGGCUUGUUUACUUUUUAAAAUUCCCACACCUCAUCCUACAAGCAAAGAC 1980 AGGUUCAUACGAUAUUUCAAAUAGAGCGCUUUGUGGACCGAAGGUAUGAU 1981 AGGUUCAUACGAUGUUUCAACUAGAGCGCUUUGAGGACCGAAGGUAUGAU 1982 AGGUUCAUACGAUAUUUCAAAUAGAGCGCUUUGAGGACCGAAGGUAUGAU 1983 AGGUUCAUACGAUGUUUCAAAUAGAGCGCUUUGAGGACCGAAGGUAUGAU 1984 AGGUUCAUACGAUGUUUCAAAUAGAGCGCUUUGAGAACCGAAGGUAUGAU 1985 AACCGUGUUUCCUUUUUAAAAGUCCCACACCUCAUCCUCCCUGCAAAGAC 1986 AACCUUGUUUACUUUUUCACAAUCCCACACCUCAUCCUCCCUGCAAAGAC 1987AACUUUGUUUUCUUUUUAAAAAUUCCACACCUCAUCCUACCUGCAACGAC 1988Attorney Docket No.: 62801.85WO01AACCUUGUUUCCUUUUUAAAAGUCCCAGACCUCAUCGUACCAGCAAAGAC 1989 AACCUUGUUUCCUUUUUAAAAAUCGGACACCUCAUCCUACAUGCAAAGAC 1990 AGGCGAGUUUACUUUUUAAAAUUCCCACACCACAUCCUACAAGCAAAGAC 1991 AACCGUGUUACCUUUUUAAAAGUCCCACCCCACAUCCCCCCUGGAAGGAC 1992 AAGCUUGUUUGCUUGUUCAAAUUCGCACACUUCAUCCUAGCUGCAACGAC 1993 AAACUUGUUUGCUUUUUCAAAUUCGGACACUUCCUCCUACCUGCAAAGAC 1994 AAGUUUGUUCCCUUUUUCAAAAUCGCACUCCUCAUCCUACAAGCAAAGAC 1995 AACCUUGUUAGCUUUUUUAAAAUGCCACACCUCCUCCUGGAUGCAAUGAC 1996 AGCUUUGUCGACUUUUUCAAAUUCCCACACCACAUCGUCAAAGCAAGGAC 1997 AAGCGUGUUACCUUUUUAAAAGUCCGAGCCCACAUCCACGCUGGAAGGAC 1998 AAGCUUGUGUACUUUUUAACAAUCGCACUCAUCCUCCACGGAGGAAAGAC 1999 AAGCUUGUUAGCUUUUUUAAAUUGCCACCCCUCCUCCUGGAUGCAAUGAC 2000 AGGCUGGUAGCCUUUUUCAAACUCCCUCACCUCCUCCCAUCAGCAAGGCC 2001 AGGCGAGUUUACUUUUUAAAAUUCCCACACCACAUCCUACAAGAAAAGAC 2002 AGGUGUGUACGCUAGUUCACAUUUGGUGCCAACCUCGACGAAGGACGGCC 2003 AGGUGUGUACGCUAGUUCACAUUGGGUGCCAACCUCGACAAAGGAAGGCC 2004 AGGUGUGUACGCUGGUUCAAAUUUGGUCCCUACAUCGUCGAAGGAACGCC 2005 AGGUGUGUACGCUGGUUCACAUUUGGUCCCAACAUCGUCAAAGGAACGCC 2006 AGGUGUGUACGCUAGUUCAACUUGGGUGCCUACACCGCCAAAGGACGGCC 2007 AACUUUGUUUGCUUUUUAAAAAUCCCACACCUCAUCCUACCAGCAAAGAC 2008 AACGUUGUUUCUUUUUUAAAAAUCCCACACCUCAUCCUACCAGCAAAGAC 2009 AACCUUGUUUCAUUUUUCAAAAUCCCACACCUCAUCCUACGAGCAAAGAC 2010 AACCUUGUUUGCUUUUUAAAAAUCCCACACCUCUUCCUACCAGAAAAGAC 2011 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCAGCAAAGAC 2012 AGGCUUGUUUACUUUUUAAAAUUCCCACACCACAUCCUACAAGAAAAGAC 2013 AACUUUGUUUGCUUUUUAAAAAUCCCACACCUCGUCCUCUAAGCACAGAC 2014 AACCUUGUUUUCUUUUUAAAAAUCCCACCCCACUCCCUAACAGAAAAGAC 2015 AACCUUGUUUCCUUUUUUAAACUCCCACACCACAUCGAACCAGCAAAGAC 2016 AACCUUGUUUCCUUUUUUAAAAUCCCACACCUCACCCGCCGUGUAAAGAC 2017 AACUUGGCUUCCUUUUUUAAAAUCCCACACCACAUCCGACCUGCAAAGAC 2018 AACUUUGUUUGAUUUUUAAAAAUCACACGCCCCGUCCUCUAAGAACAGAC 2019 AACUUUGUUUUCUUUUUUAAAAUCUCACCCCUCGUCGUAAGAGAAAAGAC 2020 AACGUUGUUUUCUUUUUAAAAAUCACUCACCUCCCCAUAAAAGUAAAGAC 2021 AACUUUGUUUGCUUUUUCAACAUCUCCCACCCCACCCAACGAGCAAAGAC 2022 AACCUUGCUCGCUUUUUAAAACUCCCUCACCACACCGAAUCAGCAAAGAC 2023 AGAAGAGUCGAGUUGUGGACUCGAAUUUGUAUUCUCAACAUACACGGGAC 2024 AGAGGAGUCGAGUUUGACUGCGGGUUCGAUAUCCUCAAAAAAGACGGGAC 2025 AGAUGGGUACAGUUUUUCAACUACAGCGCUAUCCGCGACGAAGGCACGAU 2026 AGAGGAGUACAAUUUUACAACUGCAGCGCUAUCCGCGACGAAGACACGAU 2027 AGAGGAGUCGAGUUAUACACCUGCAGCGCUAUCCGCGACGAAGAGAGGAA 2028 AGAGGAGUC C AGUUAUAC AC CUGCAGCGC UAUC C UC GAC GAAGAGAGGAC 2029 AGAGGAGUACAGUUAUACAGCCGCAGCGCUAUCCUCGACGAAGCGAGGAC 2030 AGAGGAGUAC AGUUAUUC AGC UGC AGC GCCAUCCUC GAC GAAGAGAGGAC 2031 AGAGGAGUCGAGUUAUACAGCCGCAAUGCUAUCCUCAACUAACACAGGAA 2032 AGAGGAGUC GAGUUAU AC AGC C GC AAUGC UAUC C UC GAC UAAC AC AGGAA 2033 AGAGGAGUCGAGUUUUACAGCCGCGACGCUAUCCUCGACAAACACAGGAA 2034 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2035 AGAUUAGUACGAUUUUUCAACUAGAGCGCUAUCCGCGACGAAGGCACGAU 2036AGAGGAGUACAAUUAUUCAGCUGGAGCGCUAUCCGCGACGAAGGCACGAU 2037Attorney Docket No.: 62801.85WO01AGAGGAGUAGAGUUAUAC AGC U AC AGC GC UAUC C GC GAC GAAGAC AC GAU 2038 AGAGGAGUACAGUUAUACAGCCGCAGCGCUAUCCGCGACGAAGGCAGGAU 2039 AGAGGGGUAC AGUUUUAC AGC U AC AAC GC UAUC C GC GAC GAAGAC AC GAU 2040 AGAGUAGUACAGUUUUACAACUGCAGCGCUAUCCGCGACGAAGACAGGAU 2041 AGAGGAGUAGAGUUUUAC AGC UGC AAC GC UAUC C UC GAC GAAGAGAGGAC 2042 AGAGGAGUCGAGUUAUACACCCGCAGCGCUAUCCUCGACGAAGACAGGAC 2043 AGAGGAGUAGAGUUAUAC AGC C GC AGC GC UAUC C UC GAC GAAGAC AGGAA 2044 AGAGGAGUACAGUUAUACAGCUGCAACGCUAUCCUCGACGAACACAGGAA 2045 AGAUGGAUACAAUUUUUCAACUGCUGCGCUAUCCGCGACGAAGGCACGAU 2046 AGAGGAGUCGAGUUAUACAGCCGCAAUGCUAUCCUCGACGAAGACAGGAC 2047 AGAGGAGUAGAGUUAUAC AGC C GC AGC GC UAUC C UC GAC GAAGAC AGGAC 2048 AGAGGAGUAGAGUUAUACAGCUGCAACGCUAUCCUCGACGAAGACAGGAC 2049 AGAGGAGUC GAGUUAUAC AGC C GC AGUGC UAUC C UC GAC GAAGAC AGGAU 2050 AGAGGAGUCGAGUUAUACAGCCGCAACGCUAUCCUCGACGAAGACAGGAA 2051 AGGGACCAAGAGGUCGAUACCUCAUCGAAAGCCCAAUCAAAAACCGGGUC 2052 AGGGACCAAGAGAUCGAAUCCUCAUUGACUUCCUAAUCAAAAGCAGGGAC 2053 AGGGUCAAACAAUUUGUCAACUAAUGUACCUACGGGACCUAAGGUGCGCU 2054 AGGGUCAUACAGUUUUUCAACUAAUGUACCUGCAGGACCUAAGGAGCGCC 2055 AGAUGAGUUCAGUUAUUCACCUGCAGUGCUAUCCUCGACGAAGGGAGGAC 2056 AGGUUCGUACAGUUUUUUACCUGAUGUAUCUACCGGGCCUAAGGGGGGCC 2057 AGGUUCGUACAGUUUUUUACCUCAUGUACCUACCGCGACUAAGCAGGGCC 2058 AGGGGCGUACGGUUUUAUACCUCGUGUAUCUACCGGGCCUAAGCGGGGCC 2059 AGGGGCGUACAGUUUUACACCUCAUGUGCCUACCGGGCCUAAGCGGGGCC 2060 AGGGACCAAGAGUUCGAUUGCUCAUUGACUUUCCAAUCAUAAACAGUGAC 2061 AGGGACCAAGAGUUUGAUACCUCAUCGAACUUCGAGUCAAAAGCAGGGAC 2062 AGGGUCAUACAAUUUUUCACCUAAUGCACCUGCGGGACCUAAGGAGCGCU 2063 AGGGUCAUACAAUUUGACACCUAAUCUACCUACGGGACCUAAGCUGCGCC 2064 AGGGUCGUACAGUUUUUUACCUCAUGUAUCUGCGGGGACUAAGCGGGGCC 2065 AGGGGCGUAGAGUUUUUUACCUCAUGUAUCUGCGGGGACUAAGCGGGGCC 2066 AGAGGAGUACAGUUAUACACCUGCAGUGCUAACCGCGACGAAGAGAGGAC 2067 AGGGGCCUACAGUUUUUUACCUCAUGUGUCUACCGGGCCUAAGCGGGGCC 2068 AGGGGCCUACAGUUUUUUACCUCGUGUGUCUACCGGGCCUAAGCGGGGCC 2069 AGGGACCAAGAGUUCGAUACCUCAUCGAAUUGCGAGUCAAAAGCAGGGAC 2070 AGGGACCAAGAGUUCGAUACCUCAUUGAUCUGCCAGUCAUAAGCAGUGAC 2071 AGGGACCAAGAGUUCGAUACCUCAUGGAUCUGCCAGUCAAAAGCAGUGAC 2072 AGGGACCAAGAGUUCGAUGCCUCAUCGAACUUCGAGUCAAAAGCAGGGAC 2073 AGGGACCAAGAGUUCGAUACCUCAUCGAACUGCCAGUCAAAAGCAGGGAC 2074 AGGGUCAUACAGUUUGACACCUAAUGUACCUGCGGGACCUAAGCAGGGCC 2075 AGGGUCCUACAGUUUGACACCUAAUGUACCUGCGGGUCCUAAGCAGCGAC 2076 AGGGUCCUACAGUUUGACACCUCAUCUACCUGCGGGUCAUAAGCAGGGCC 2077 AGAGGUGUACAGUUUUACACCUGCAGUGCCAUCCUCGACGAAGAGAGGAC 2078 AGGGUCAAACAGUUUGACACCUAAUGGACCUGCGGGUCAUAAGCUGCGCC 2079 AGGGUCAUACAGUUUGAUACCUCAUGUACCUGCGGGACAUAAGCAGCGCC 2080 AGGGUCGUAGAGUUUUUUACCUCAUGUAUCUGCGGGUCCUAAGCAGGGCC 2081 AGGGUCCUACAGUUUUAUACCUCAUGUAUCUGCGGGGCCUAAGCAGGGCC 2082 AGGUUCGUAGAGUUUUAUACCUCAAGUAUCUGCUGGUCCUAAGCAGGGCC 2083 AGGGUCGUAGAGUUUUUUACCUCAUGUGUCUGCGGGGCAUAAGCAGGGCC 2084 AGGGUCGAAGAGUUCUAUACCUCAUGUGUCUGCCGGGCAUAAGCGGGGCC 2085AGGGGCGUAGAGUUUUAUACCUCAUGUAUCUGCCGGUCCUAAGCAGGGCC 2086Attorney Docket No.: 62801.85WO01AGGGGCGUACAGUUUUAUACCUCAUGUAACAACGGGUCCUAAGCAGGGCC 2087 AGGGGCGAAGAGUUCGAUACCUCAUGUAUCUACCGGGCCUAAGCAGGGCC 2088 AGAGGGGUACAGUUUUACACCUGCAGUGCUAUCCGCGACGAAGAGAGGAU 2089 AGGGGCGUACAGUUUUAUACCUCAUGUAACUACGGGUCCUAAGCAGGGCC 2090 AGGGGCCUACAGUUCUAUACCUCAUGUAACUGCCGGUCCUAAGCAGGGCC 2091 AGAGGAGUCGAGUUAUACAACCGCAAAGACCUCAUCCAAGAAGACAGGAC 2092 AGAGGAGUUGAGUUAUAC AAAAUC C CACACCUCAUCC U AGAAGC C AGGAC 2093 AGACUAGUUGACUUUUACAAAAGCCCACACCUCAUCCUAGAAGACAGGAC 2094 AGAC UAGUUGAC UUAUAC AAC AUC C AAC AC C UC AUC C AAGAAGAAAGGAC 2095 AGACUAGUUUACUUUUUCAAAAUCCCACACCUCAUCCUACCAGCAAGGAC 2096 AGAGGAGUCGAGUUACACGUCCUCGAGGCUAUCCUCGACAAACACAGGAA 2097 AGACUAGUUUACUUUUUCAACAUCCCACACCUCAUCCUACCAGCAAGGAC 2098 AGACGAGUUGACUUUUUCAACUUCCCACACCUCAUCCACCAAGAAAGGAC 2099 AGAGGAGUCGAGUUAUUCAGCCGCAAUGCUAUCCUAGACUAACACAGGAA 2100 GGGUGAGUUGAAUUUCAAGGCCGAAAGGCUUAGACAGACGUAUCCAUGAC 2101 GGGUGAGUUGAAUUUUAAACCGUAAAGGCUUAGCCAAGAGUUAUAGGGAC 2102 AGAGGAGUUGAAUUAGAAAC GC GAAAC GC UUAGAUAGAC GUAUAC AGGAC 2103 AGAGGAGUUGAAUUUAAAGGCCCCAACGCGGUUAGUGGCUAUCACAGGAC 2104 AGAGUUGUUUAAUUGAAUCUCCGAAACGCUUUGUCCGACGUAUACAGGAC 2105 AGAGGAGUUGAAUUUCAAGGUUGCAACGCUGUUAGAGGCCAACACAGGAC 2106 AGAGUUGUUUAAUUGAAAUGCCCAAAUGCUUGCCCAGACGUAUACAGGAC 2107 AGAGGAGUUGAAUCUUACAAAGGCAACGCUAAUAGCGCCUAACACAGGAC 2108 AGAGGAGUUGAAUCUUAAAACCGCAACGCUUUCAGAGGCUAUCACAGGAC 2109 AGAGGAGUUGAAUCUUUAAACCGCGACGCUUUGCACGACCUAUACAGGAC 2110 AGAGGAGUUGAAUCUUUCAAAGGCAACGCUAUUCACGACCAACUCAGGAC 2111 AGAGGAGUUGAAUCUUACAAAGGCAACGCUGGCCACGACAAACUAAGGAC 2112 AGAGUUGUAAAGUUUAACCCGCGAAAGGCUACAGACGACUAUAUAGGGGC 2113 AGAGGAGUUGAAUUUUACAGCCGCAACGCUUAGAUAGACGUAUACAGGAC 2114 AGAGGAGUUGAAUUAUAC AGC C GC AAC GC UAUC C UC GAC GAAGUC AGGAC 2115 AGAGGAGUUGAAUUUUACAGCCGCAACGCUAUUCUCUACGUACACAGGAC 2116 AGAGGAGUUGAAUUAUAC AGC C GC AAC GC UAUC C UC GAC GUAC C C AGGAC 2117 AGAGGAGUUGAAUUUUACAGCCGCAACGCUAUCCUCGACGUACACAGGAC 2118 AGCCUUGUUUCCUAUUUAUAAAUGUUAGUCCACUUCCUAAAUGCGACGAC 2119 AACGUUGUUUCGUGUUUGAACAUCCAAUGCUACUUCCUAUAUGCGACGAC 2120 AGCAUUGUGUGCUUUGUAACAGUUACUCGUCUUAUCCCAUAUUCCGUGAC 2121 AGCCUUGUUUCCUUUUUGAAAAUCCUAUUCCAAUUCCUAAAUGCGGUGAC 2122 AGCCUUGAUUCCUUUUUAAAAAUGCUACUCCACUCCCUACAUGCGACGAC 2123 GGGUGAGUUGAAUUCAAGGACCUGAUCUUAAUUAGAGACGUAUACAGGAC 2124 AGCCUUGUUUCCUUUUUAAAAUUUCAACGCCACAUCCUAAAUGCGACGAC 2125 AGCCUUGUUUCCUUUUUAAAUAUUCCACGCCACAUCCUACAUGCGACGAC 2126 AGCCUUGUUUCCUUUUUAAAAAUCCCACCCCUCAUCCUACAUGCGACGAC 2127 AGCCUUGUUUCCUUUUUAAAAGUUCCACUCCUCAUCCAAAAUGCGACGAC 2128 AGAGGAGUCGAGUUGUGAAGUCCCAAUUCUAUCCUCAAAAAAGACGGGAC 2129 AGAGGAGUCGAAUCGUACUUCCGCAUUGUUAUCCUCAACAGAGACAGGAA 2130 AGAGGAGUCGAGUGGUACUGCGGCAUUGUUAUCCUCAAAAAAGACGGGAC 2131 AGAGGAGUCGAGUUACACGCCCGCAACGUUAUCCUCGACAUACACGGGAC 2132 AGAGGAUUUGAGUUUUAUAGCCUCAUCGCUAUCCUCAACAAACACCGGUC 2133 AGAGGAGUCGAGUUUUUCAGCCGCAUUGAUAUCCUCGACAAACGUAGGAA 2134GGGUGAGUUGAAUUUUUAUGCCCAAAUGCUUAGACAGACGUAUCCAUGAC 2135Attorney Docket No.: 62801.85WO01AGAGGAGUC GAGUUAUUC AGC C GC AAUGC UAUC C UC GAC UAAC AC AGGAA 2136 AGAGGAGUCGAGUUAUACAGCCGCAAUGCUAUCCUCAACGAGCACAGGAA 2137 AGAGGAGUC GAGUUUGAGAGC C GC AAC GC UAUC C UC AAC UAAC AC AGGAA 2138 AGAAGUGACGUGCUCUCCACCCGCUAUCCGGUCCUAUAAUAAGCAAGGCA 2139 AGGGGAGUUGAGUUCUACAGCCCCUACCCGAUCCUAGAAAAAGCCGGCAC 2140 AGGAUUGUAUUCUAAUACACCAGCAACCAGAUCCUCGACGCAGACAACAC 2141 AGCCGUGUUGACUUUUUAAGCCGCCGACAUCUCCUCCACUCUCAAACCAU 2142 AGGGUAGUCCACCUUUCCUACACCUAACCUCUUAGCCACCAUGAAAAGAC 2143 AGGCGAGUCUGGUUAUUCUGCAUCCCCGCCAUCAUCGAACGUCAAAAGAC 2144 AGGGUAGUAGACUUUUUAAGCUUCGGGGAUCAUAUCCAACCAGACACGAC 2145 CGGAGAGUUGAAUUUAAGCGGCCAAAGGCUUAGACAGACGUAUACAGGAC 2146 AAACUAGUCUAAUUUUUAAAUAUCCCCAACCUUCGCUUAGCUCACACGAC 2147 AGGAGAGUUGAAUUACAACAUGCAAUGGCUAUACAGGUCGUAUACAGGAC 2148 AGGAGAGUUGAAUUACAACCCUGAAAGGCUACGCCAUAGCAAGACAGGAC 2149 AGGAGAGUUGAAUUACAACCCUGAAAGGCUAAGCCCUAUAACGACAGGAC 2150 AGGAGAGUUGAAUUUCAAACUGGAAUGGUUAUACAGGUCGUAUACAGGAC 2151 AGAGGACACUUCCUUUUGCGGGUGGCGGCGAACGCGGAGAGCACGCC 2152 GCAGAUAAUGGGAGGAGCCGGGCCCGAGCGAGCUCUUUCCUUUCGCUGCUGCGGCCGCAG CC 2153 AAAAAGGAGGAGCUUCAACCUGUGUGCAAAAUCUGGGAACCUGACAGUAUAGGUUGGGGG CCAGGAUGAGGAAAAAGGAACGGGAAAGACCUGCCCACCCUUCUGGUAAGGAGGCCCCGU GAUCAGCUCCAGCCAUUUGCAGUCCUGGCUAUCCCAGGAGCUUACAUAAAGGGACAAUUG 2154 GAGCCUGAGAGGUGACAGUGCUGACACUACAAGGCUCGGAGCUCCGGGCACUCAGACAUC GCAGUUCGGCGGUCCCGCGGGUCUGUCUCUUGCUUCAACAGUGUUUGGACGGAACAGAUC CGGGGACUCUCUUCCAGCCUCCGACCGCCCUCCGAUUUCCUCUCCGCUUGCAACCUCCGG GACCAUCUUCUCGGCCAUCUCCUGCUUCUGGGACCUGCCAGCACCGUUUUUGUGGUUAGC 2155 UCCUUCUUGCCAACCAACC AGUUCACAGCUGCCCUGUUGCAGGGAGGCGGUGGCCCUUCUGUUGCUAGACCGAGCCUGU GGGAUAUAC C AAGGC AGAGGAGC C C AU AGC C 2156 CCCCAGCUCGCCUUCACACACAGCCCGUGCCACCACACCGACGGUACC 2157 CAGUCCACUUAAAUGCAGCUCCAGGGUUGCGAGGCACCCACCAGCAUCAUUCCCCAUGCG AGGUGGCAAAUGCAAC 2158 GUAAGAAGAGGCCGCUCUUCCUGGGGUUGUUUCUCCGUGUGACGUGUGGCCUUUGAGAUC AACUCUCCUGUACCAGCGUAGGCCGC 2159 AAAUCAUUGCGUAGUUCCGAAUACCCUCGGCCACACCUGGCCUUCUCC 2160 AGCAACGUCAGGGCCAGGGCCGCGAGGUAGUUGGCAGAGGCCUCGGGGUCCUCCUGGAAG GGGCCUC 2161 CCUCUGCCCAGUCCUGGGGUCCCGCGGCCGCCUAGGAGGGAGCCCGCCGGGGCGGGGCGG GGCCGGGUGCCC 2162 CCGUCCCGUUGCCCCGGCGACCGCGGCGGUUUGUUCUCAGGCCCCGGCCUUUCUCACCGU GCGACGCCCCAACCCGCCGCUCCGCCGCGGUGGUACGCUCCAGGCCGCCAGGCCGCGAGG 2163 CCCACCGAGCGGACGCCAGUGG CCUUUUCCGGUUGCGGCGCCGCGCGGUGAGGUUGUCUAGUCCACGCUCGGAGCC 2164 CCCUCCUCUUCCUUUCUCCGCCAUCGUGGUGUGUUCUUGACUCCGCUGCUCGCC 2165 AGAGGAAACUGUUGAGAAAACGGAACUACUGGGGAAAGGGAGGGCUCACUGAGAACCAUC CCGGUAACCCGAUCACCGCUGGUCACC 2166 ACUGGAAAAGAUAGUGACCUUACCAGGGCCAAAGUUUGUAGACACAGGAAUUACGAAAUG GAGAAGGGGGAGAAGUGAGCUAGUGGCAGCAUAAAAAGACCAGCAGAUGCCCCACAGCAC 2167 UGCUCUUCCAGAGGCAAGACCAACCAAG AGAUGCCCCACAGCACUGCUCUUCCAGAGGCAAGACCAACCAAG 2168 AAUCCUUUCUUUCAGCUGGAGUGCUCCUCAGGAGCCAGCCCCACCCUUAGAAAAG 2169AGGGAACAUAUAAUACUAAUAUUGCGGAACAACACGCGGACAGCACGGCC 2170Attorney Docket No.: 62801.85WO01AGGCAAAAUAUGAUACUUAUAUUGCCGAACAAACCGCGCACAGUAUGGCC 2171 AGGCAGCAUACGAUAUCUGCAUUGCCGAACAAAAAGCGCACAGUAUGGCC 2172 AGGGAGUAUACGUGAUCUGCAUUGCGCAAACAAACGUGCACAGUAUGGCC 2173 AGUGGGUAUACGUCAUCUGUAUUGCCCGACCAACCGAGCACAACAUGGCC 2174 AGGCGGUAUCCGACUUCUUCAUCGUCCUAACAGCCGCUAACAACAUGGCC 2175 AGGCGGUAUCCGACUUCUUCAUUGUCCUACUAGCCGCAAUCACCAUGGCC 2176 AGGGAAGUUAUAUUAAUAAUCUUGCAGAUCAAACCGCAGAGAGGAGGGUC 2177 AGGCGAUUCACGACUUCUUUAUUGUCCUACCUGCCCCAGUCACCAUGGCC 2178 AGGCAAUUCACGAAUUCUUUUUCGUCCUAAUUGCCCCACUAACCAUGGCC 2179 AGGUAAAUUAGAUUAAUAAUAUUGCGAAUCAAACCGCGCACAGCAGGGCC 2180 AGGGAAUUUACCACUUCUUUUUAUCUCCUAUUACACCCGUAACCAUCGCC 2181 AGGGAAGAGAGAAUAACAGUAUUGCGAAACAAAAAUCGCACAGCACGGCC 2182 AGGGAAUUUACGAAUUCUUUUUAUUUCUAAUUACACCCCUCACCGGGGCC 2183 CUCAAGUAUUAAAGACUUGAAGCGUAAGUAACUGAGUUCUUGUUGUUUACAGAGAUGCUG AAGCAAGACAACCUCUCUGGAGAAAAGUCCCAAUCUCUUCGAGCAAAAUCAGUCCUUACC GCAUCGUGAUCGUUCUUCGCCUUGUGAUCUUAGUUUUCUUCUUCCGUUUCCGUAUCUUGA CACCAGCCAAAGACGCAUACCCUCUCUGGCUUAUCUCAGUCAUCUGCGAGAUCUGGUUCG 2184 CUCUCUCUUGGAUCCUUGAUCAGUUCCCGAAAUGGUUUCCGAUUAACCGAGAAACCUACC UUGACCGUCUCUCU GUGACCUGACCCCCCUCCUGCCCACCGCUUCCCUUCUUCCCGGGACUUUAGUAUUAUGCG GGAUUCGUUUCGGUUUAGUUCCGUUCAGUUCAGUUCUCUGUCAUGCGCAUUCUGCAGUGA AAGCCCAGUCUAAAUAUGAUUCAUGUUCAAUCCAUCCAUAACCAUUAACACACUCAAACU 2185 C GAAC AC C AAUC AAAC C AAAC C AAAC C GAAC C GAAC C AAAC C AAAC C U CUGCUGAUCUAUUCCUGCUGAAUGAUGAAGGGUGAUCAAUGACUGCACAUCUGUGAUUGU UUCUCAGUGUCUGCUAGAGUUUCUGCUGGACAUCACACUCUUCACAUCCAUC 2186 GCACAGCCUCCAACGGGUCCUAGUCUCAAAGACUAUCCUCCUUCGACGCAUCUUUUCCAA UCGUGCGAAGGAUCUCCUCGUGGAUCUGUAUCUCCUCGAGCCUCUGGAUCUCCUCGAGGC 2187 UCUGGAUCGACUCAACCUCA ACUUACUUUGAUUUCUUUUUGUUAUUACUUUCAUAUAAAGAAACUGUUGAA 2188 GCUUGAGAACUUUCUUCACUCUUUCAACUGCUAAGAAGAAAUAGAGAAAACU 2189 GGGCAGGGAAUACUUCAGUUGACGAGCUUCCGUCCAGACGAACAGAUCGAC 2190 AGUUUUGAGAUUUGUGAUUGCCUCCAUGCAAGAGCUGAAUUAGCCGAAUCUGG 2191 AGCUGUUUGGUUUGUUCGUUGUGUAACUUAACUGAACGCGUUGAAUUUUUG 2192 GAAGGAUUCUUCAAAAUUAACAGAAACCAAUUCGGGCCAGCUGAAGAGAAAAAAUAAAG 2193 CAUUGGAGUUUCCAUCAGGACUCCAGGUCCCCUAUCCUGUCCUCUGCAACCCAAACGUCC AGGAGGAUC 2194 AAACAAAAUUUGUCGUUUUUAUAAACCAGAAAAGCUGCCCAACUUCUUCUCCUCUCGAAC CCUAACGAGCCGGGUCAUCUCAAAAAUUUCUCCGACAUUGCAUUCCUCCGUCGCCUUCAG AUUCUUCUCCAGCGUUCCUUAAUCUCUUCUUCUCCGGUCGAUUCCACCUUCUUCAUCCCC 2195 AAAACCGAAGUCCUUAUACCGUAAUUUUAUCAAGUUUUUUACCGAACCGAUUUCUUGCCG UAAC C AAC C C GGUC AC AAAC C UGC AAAC C AAAAAAG GAGAGAACCCACCAUGGUGCUGUCUCCUGCCGACAAGACCAACGUCAAGGCCGCCUGGG 2196 GUUUAAGUUUUUGAAACUGAAGUAGGCCUACACAGUAGGAACUCAUGUCAUUUCUU 2197 GGUUGCUUUGUUUUUAAGCCAAACUCCAAAAAGAGAAAGAUCUCUCUGCCAAUAG 2198 AUUCCAGACUUCUGCGGUUCAAAUUGCAACUAGGAGGCCGGCCUAAUCAUGCAG 2199 UGAAGCGCAUUUUCCGUGCAGAAGCUUCAGGAGUCAAAACAAGCAGCCAGG 2200 GAGCCAUUCCGUAGUGCCAUUCGGAGCGACGCACUGCCGCAGCUUCUCUGAGCCUUUCCA GCAAGUUUGUUCAAGAUUGGCUCCCAAGAAUCAUGGACUGUUAUUAUAUGCCUUGUUUUC 2201 UGUCA AUAAAAAAAAAGCGUUGCUUCAACUGGUCUAGGAACAGAAUACAAAUCAAA 2202CUCACCGUUCCAGAAAUUUUGCAUUAACGAAGAUACCGAGUGCUUAGAAGG 2203Attorney Docket No.: 62801.85WO01UUUUCGGACCAACCGAUUGCCAUUUGUGAACCAUAUCCACAGCUCCUGAAUCCAUAUACU GCUCCACUCUAAACACCGUAACGACCGAUGGCACAGGAACAAGCUUGACUUUGUAUCCCA AAACGACGCCGUAGCUACCUCCUCCUCCACCGGUAAUCGCCCAGAAAAGAUCCUCACCCA 2204 UUGCUUUCCGAUCUAAAACCCGACCGUUUACAUCGACGAUCUUGGCAUCCUCAACGUAAU CCACAGAUAAUCCAAACUUCCUCACCAUGUUACCGUAACCACCGCCGCUUAA CAAUGGCAGCAGGGGCAGCGGAUGGUGAUUUACGGAGCGGUUUUCCUCAUCACGACGCUC CUCAUCCUCUACAGCUCCAGCAGCUCAGCUGAUCUUUCCAGAUCCUUCAAGACAAGCAAC 2205 UUCCGUCAAAUCCACCACACGCUCAAAACCACCAACCUCAAGAA AACCUCUUCGGUCCGCGACGAUCCUCUAGAGCACUGUGUGUCUCCCCGGACGCGAGCCCG CUCCCCUGA 2206 CCGAACCGAGGCCACCCGGAGCCGUGCCCAGUCCACGCCGGCCGUGCCCGGCGGCCUUAA GAACCCGGCAACCUCUGCCUUCUUCCCUCUUCCACUCGGAGUCGCGCUCCGCGCGCCCUC ACUGCAGCCCCUGCGUCGCCGGGACCCUCGCGCGCGACCGCCGAAUCGCUCCUGCAGCAG 2207 AG GUGGUGAAACUGGCAGUUGACGGCUCCUGGGACUAGAUCCCGCGAGGUAGCCCCCGAACU AUUUCUCUACGUUUUCUCUUGAUCCUCCCGAAAUCUUCCAGAUCCGCGUAGUGAGGAAUC 2208 GUCUCCACCGUC UUUUAAUCCCAAUUAGUCUCCUUCUCCUUUCUCUCUGCUCUCUCGUUCAACGGGCAAAGU UUUUUUCGAAUAAAGUUUUGGUUUUUCUUUUAACGUUCCCUUCUUCUUCCUCCUCCUCGC 2209 GAAUUCGCUUAUCUGUCGAUCACG AAACACGCACGAGCAAGAGCGCGACGGCCCAGAGUGCAGUUCGGCCGUCAGAUUUGCCAG UCAUCUUCAGCAUCAGUUCUGAGCUGCAGCAACUCAGAGGAGCUGUUUAUUUACAUUACC 2210 GGAGAAUUAC C GAG ACC GAAC AC C GAC AC C GGGC GGC AAC AUUAAAGCUUUAUACCUUCCCAGGUAACAAAGCAACCAACUUUCGAUCUCUUGUAGAUCU GAUCUCUAAACGAUCUUUAAAAUCAGUGUGGCUGUCACUCGGCUGCACGCUUAGUGCACU CACGCUGUAUAAUUAAUAACUAAUUACUGUCGUUGACAUCGUUUGGGUACCUCGGCUAUC 2211 UUCUGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUU CGUCCGGGUGUGACCGAAAGGUAAG AAUUAAGCUGUAUACCUUCCCAGGUAACACAGCAAUUAAAAAACCUACUGAAAAAGUAGU GGACGAAAAAAGUCCUAUAACACCUCUGUAGCUGACACUCUGGUGCAUCCAUAGUGAACA C GAC UAC UAAUAAUAGUAAAUAUUAAGUAGCUC UAACAAAAC GCAAGUAACUUGC CUAUC 2212 UUCUGCAGACUGAUUACUGUUUCGUCAGUGUUUCAGUCGAUCAACAGCACAACGAGGUGA CGUCCGGGUGUAGCCGAAAGGCAAG CUUAAAGCUUCACACCGGAAACGGUGAGGAAGCAAUAAUAUUUAGAUCCGAUAAGGAUCA GUACUCUAAACGUACAUUAAGACCUGGGCCGCUCACACUGGGCGGAAAGCUGAGUGAAAU AGCCCAGCAUCCUUGGUAAACAAGGGCUGGCGCAAAUAUAAAGCGAGUAACUCGCAUAUA 2213 AUAUAAAGGCUGCUUACGGUUUAAUCCGUGUUGCAGCCAAUAAAGAGCGCCUACAGGUCA CGUCUGGGCGAAACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAAUAAAAUUUCGAUCUCUUAUAGAUCU GUUCGCUAAAAGAACUUUAAGAUCUGGGCAGCUGACACUCGGCAGCAAGCUUAGUGAACU CGCGCAGUAUACUUAAUAACUAAGUACUGUAGCUGACAGGACACGAGUAACUCGUCUAUA 2214 UUCUACAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAACAGCGCCUACAGGUCA AGUACGGGUGUGACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCA GUACGAUAAUAGUACAUUAGAAUCUGGGGAGCUGUCAUUCGGCUGCCGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGCUAGUAAUAGCUGUGGUUCACAGGACACGAGUAACUCGU 2215 CGAUAAUAUACAGACAACUCACCGGUACGUCGGUGUUGCAGCCGAUCAUCAGCCCCUACA GGUUCCAUCUGGGAGAACGCGAAAGCGAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GCUCUCUAAACGAGCUUUAAAAUCUGUGUAGCUGUCACUCGGCGGACGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGGCGCUAACGCCUGUCGUUGACAGGACACGAGUAACUCGU 2216 CUAUAUUCUACAGACUGCUCACGGUUUCGUCCGUGUUGCCGCCGAUCAUCAGCACAUCCA GGUUAC GAC AGAAUAAGGC C GAAAGGC AAA AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUAGUUGUCACUCGAUUGCCGCGUUAUUGUUCU 2217GCCGGGCGGACACGUGACGCGGAAGUAAUUCCUGUUGUUAACAGUAAACGAUUAAAUCGUAttorney Docket No.: 62801.85WO01GGAUCUUCUAAACGCUGCUUACAGUUUCGUCUGUAUUGCAAUCGAUCAUCAACACAUCCA GAUUUCAUCCGGUUGUGACUGAAAAGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCA GUACGAUAAUAGUACAUUAGAAUCUGGGGAGCUGUCAUCCAGCUGCCGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGCAGGUAACUGCUGUGGUUCACAGGACCCUAGUAACUAGG 2218 CGAUAAUAUACAGACAACUCACCGGUACGUCGGUGUUGCAGCUGGUCAUCAGCCCCUACA GAUUCCGUCUGGGAGAACGCGAAAGCGAAG AUUAAAGCUUUAUACCUUCCCAGGUAACAAAGCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCAAAACCAAAAUAAAACCAGAAUCGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGCAGCUGGUUACUGUCGUUGACAUCGUUUGGGUACCUCGG 2219 CUGUGGUCUACAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUA GGUUUCGUCCGGGUGUGAGCGAAAGCUACC AUUAAAGGUUCACACCUGAAAAGGUGAGGAACCAAUUAAAUUUCGAUCUGAAGAAGAUCA GUACGAUAAUAGUACAUUAGAAUCUGGGGAGCUGUCAUCCAGCUGCCGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGCAGGUAACUGCUGUGGUUCACAGGACCCUAGUAACUAGG 2220 CGAUAAUAUACAGACAACUCACCGGUACGUCGGUGUUGCAGCUGGUCAUCAGCCCCUACA GAUUCCGUCUGGGAGAACGCGAAAGCGAAG AUUAAAGCUUUAUACCUUCCCAGGUAACAAAGCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCAGUGUGGCUGUCACUCGGCUGCACGCUUAGUGCACU CACGCUGUAUAAUUAAUAACUAAUUACUACCAGUCAAAUUGCGAGGGAACCAGCUAUAUC 2221 GUCUACAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUU CGUCCGGGUGUGAGCGAAAGCUACG AAUAUAGCUUCGUACCUGAACAGGUAAAGAAGCAAUAAAUAAUAGAUCUGAUAAAGAUCA GUGGGAAAAAACCACAUUAAGACCUGCGCAGCUGUCACUCCGCGACGUGCGUAGUGCACU CCGGCAGCGUGAUUAGUAAAUAAUCGCUGCACGUAACAAUACACGAGUAACUCGUCAUUC 2222 AUAAGCAGGCUGCUUACGGGAUAAACCGUGUUGCAGCCGAUCAUCAGCGCGAAUAGGUCA CGUCAGGGUGUAACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAGCCCUGCGCAGCCGUCACCCGUCCCACGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGGCCCUAAGGCGUGGCGUUGCCACGACCCGAGUAACUCGG 2223 CUAUAUUCUACAGACUGCUGGCGAUUUCGUUCGCCUUGGGGACGGUCAUCGGCGCGUCCA GGGCACGACCAGAUAUAGCCGAAAGGCAAA AUUAAAGGUUUAUACCUUCACAGGUAACAAACCAACGAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAGCCUGCGGAGCUGUCACGUGGCAGCAAGCCUCGUGCACU CGCCCAGCAAGCUCCAUAACGGAGCGCUGGCGCUGACAAAACCCGAGUAACUCGGCUAUC 2224 UUCUGCAGGCUGCUCACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCCCGUCCAGGCUA AGUACGGGUGUGGCCGAAAGGCAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUAGCGGUCACUGGGCGAUAAGCUGAGUGCAAU UCCGCAGUAAUAUUAGUAAAUAAUAACUGCUGGUAACAUUACACGAGUAACUCGUCUAUC 2225 UUCUACAGGCUGCUUACGGGAUAUACCGUGUUGCAGCCGAUCAUCCGCACAUUCAGAUUA C GUC C GGAAAUAAC C GAAAGGUAAG AUAAAAGCUUUAUACCUUCCCAGGUAACAAAGCAAAUAAAAAUUGAUCACUUGUUGAUCU GUUCGCUAAAAGAACUUUAAGAUCUGUGUAGCUGUCAUUCUGCUCACGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGCAAGUAAUUGCUGUCGUUGACAGGACACGAGUAACUCGU 2226 CUAUCUUCUACAAACUGCUCACCGUUUCGUCGGUGUAGGAGCAGAUCAUCAGCACAUCCA GGUCACAUACAAGUAUAACCGAAAGGUAAG AUUAAAGGUUCAUACCUGCCCAGGUAACGAACCAAAUAAAUAUACACCCGAAUAGGGUGA GUUCGAAAUAAGAACAUUAAAAUCUGACCACCUGUCUGACUCCGAAAAGGGUUCAGCAAA CGCCCAGCAUCACUAGAAUAUAGUGGCUGGAGCUGAGAGGACACGAGAAACUCGUCUAAC 2227 AACACCAGGCUGCUUACGGGAAUAACCGUGUUGCAGCCGAUCAUCAGGGGUUCCAGGUUA AGUAAGGAAGAAGCCGAAAGGCAAU AUUAAAGGUUUACACCUUCCCAGGUGAGAAACCAAAUAAAAAUAGCUCCGAUAAGGAGCA GUGCGAUAAAAGCACAAUAAGACCUGGGGAGCUGAGACUGGGCGACAAGCUGAGUCAAAU 2228AGCCCAGGAAGAUUCGUAAAGAAUCCCUGGAGCAAAUAAAAAGCGAGUAACUCGCAUAUAAttorney Docket No.: 62801.85WO01UUAUAUAGGCUGCUUACGGGAUAAACCGUGUUGCAGCCAAUUAACAGCCCCUACAGGUCA AGUACGGGUGUAGUCGAAAGACACC AUAAAAGGUUGAUACCUUCCCAGGUAAACAACCAAUAUAAAUAAGAACUGUUGAAGUUCA GUAGGCUAAUACUACAUUUAGAUCUCGGCAGCUGACAGUCGGCUCACGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGGCCCUAAGGCCUGACGUUGUCAGGACACGAGUAACUCGU 2229 CUAUCAUCUACAGACUACGGACGCGUUCGAGCGUUUUGGAGCCGAACAGCAGCGCCAAGA GGUCAAGUACAACAAAGACCGAAAGGUAAG AAAAAAGGUC C AU AC C UAC C AAGGUAAAGGAC C AAAAAAAAAAAGAUC C AUUGAGGAU C A GUCCACUAAAAGGACAUUAAGCCCUCCGGAGCUGUCACUCGGCUCACGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGGCGGUAACGCGUGCCAAAGGCACAAAGCGAGUAACUCGC 2230 AAAAAAAAAAAAAAAAAGACACGGAUUCGACCGUGAACGAGCCGAUCAUCAGCCCGAAGA GGGCAAAUAAGAAAAAGACCGAAAGGUAAA AGGCACAGACACCAAGGACAGAGACGCUGGCUAGGCCGCCCUCCCCACUGUUACCAAC 2231 ACUCCUCCCCAUCCUCUCCCUCUGUCCCUCUGUCCCUCUGACCCUGCACUGUCCCAGCACC 2232 AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCAUGCUUAGUGCACU CACGCAGUAUAAUUAAUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUC 2233 UUCUGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUU CGUCCGGGUGUGACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCCGCGUUAUUGUUCU GCCGGGCGGACACGUGACGCGUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGU 2234 CUAUCUUCUGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUA GGUUUCGUCCGGGUGUGACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACU CACGCAGUAUAAUUAAUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUC 2235 UUCUGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUU CGUCCGGGUGUGACCGAAAGGUAAG AUUAAAAACCAACUUUCGAUCUCUUGUAGAUCUGUUCUCUAAACGAACUUUAAAAUCUGU GUGGCUGUCACUCGGCUGCUUGCUUAGUGCACUCACGCAGUAUAAUUAAUAACUAAUUAC UGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUCUGCAGGCUGCUUACGGUUUCGUCC 2236 GUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGUCCGGGUGUGACCGAAAGGUAAG UUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACUCACGCAGUAUAAUUA AUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUCUGCAGGCUGCUU ACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGUCCGGGUGUGACC 2237 GAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCUGUUCUCUAAACGAAC UUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACUCACGCAGUAUAAUUA AUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUCUGCAGGCUGCUU 2238 ACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGUCCGGGUGUGACC GAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU UUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACUCACGCAGUAUAAUUA AUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUCUGCAGGCUGCUU 2239 ACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGUCCGGGUGUGACC GAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUUAUAAUUAAUAACUAAUUACUGUCGUUGACAGGACAC GAGUAACUCGUCUAUCUUCUGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAU 2240 CAGCACAUCUAGGUUUCGUCCGGGUGUGACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACU 2241CACGCAGCUGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUCUGCAGGCUGCUUACGGAttorney Docket No.: 62801.85WO01UUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGUCCGGGUGUGACCGAAA GGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAU 2242 AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUC UGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGU 2243 CCGGGUGUGACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACU 2244 CACGCAGUAUAAUUAAUAACUAAUUACUG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACU CACGCAGUAUAAUUAAUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUC 2245 UUCGCACAUCUAGGUUUCGUCCGGGUGUGACCGAAAGGUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACU CACGCAGUAUAAUUAAUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUC 2246 UUAAG AUUAAAGGUUUAUACCUUCCCAGGUAACAAACCAACCAACUUUCGAUCUCUUGUAGAUCU GUUCUCUAAACGAACUUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACU CACGCAGUAUAAUUAAUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUC 2247 UUCUGCAGGCUGCUUACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGAAG UUUAAAAUCUGUGUGGCUGUCACUCGGCUGCUUGCUUAGUGCACUCACGCAGUAUAAUUA AUAACUAAUUACUGUCGUUGACAGGACACGAGUAACUCGUCUAUCUUCUGCAGGCUGCUU ACGGUUUCGUCCGUGUUGCAGCCGAUCAUCAGCACAUCUAGGUUUCGUCCGGGUGUGACC 2248 GAAAGGUAAGUUGGAGAGCCUUGUCCCUGGUUUCAACGAGAAAAC CGCGCCUAGCAGUGUCCCAGCCGGGUUCGUGUCGCC 2249 CUCCCGGGCUGGCAGCAGGGCCCCAGCGGCACC 2250 AGUUGUUAGUCUACGUGGACCGACAAAGACAGAUUCUUUGAGGGAGCUAAGCUCAACGUA GUUCUAACAGUUUUUUAAUUAGAGAGCAGAUCUCUG 2251 ACCGCCGGGACCGCGUCCGCCCCGCGAGCACAGAGCCUCGCCUUUGCCGAUCCGCCGCCC GUCCACACCCGCCGCCAGCUCACC 2252 AGCACCACGGCAGCAGGAGGUUUCGGCUAAGUUGGAGGUACUGGCCACGACUGCAUGCCC GCGCCCGCCAGGUGAUACCUCCGCCGGUGACCCAGGGGCUCUGCGACACAAGGAGUCUGC 2253 AUGUCUAAGUGCUAGAC UAUAAAACCCGGCGGCGCAACGCGCAGCCACUGUCGAGUCGCGUCCACCCGCGAGCACAG CUUCUUUGCAGCUCCUUCGUUGCCGGUCCACACCCGCCACCAGUUCGCCCC 2254 GGCGAACUGGUGGCGGGUGUGGACCGGCAACGAAGGAGCUGCAAAGAAGCUGUGCUCGCG GGUGGACGCGACUCGACAGUGGCUGCGCGUUGCGCCGCCGGGUUUUAUACC 2255 CUUCCUUUUGUGACUGGCGGUGAACGAGUGCGCAGUGCCCGCGUUAUUGUUCUGCCGGGC GGACACGUGACGCGAAGCUUUAUAAAACCCGGCGGCGCAACGCGCAGCCACUGUCGAGUC GCGUCCACCCGCGAGCACAGCUUCUUUGCAGCUCCUUCGUUGCCGGUCCACACCCGCCAC 2256 CAGUUCGCCCC CUUCCUUUUGUGACUGGCGGUGAACGAGUGCGCAGUGCCACAUUUGCUUCUGACACAACU GUGUUCACUAGCAACCUCAAACAGACACC 2257 CUUCCUUUUGUGACUGGCGGUGAACGAGUGCGCAGUGCC 2258 CGCGUUAUUGUUCUGCCGGGCGGACACGUGACGCGAAGCUUACCGCCGGGACCGCGUCCG CCCCGCGAGCACAGAGCCUCGCCUUUGCCGAUCCGCCGCCCGUCCACACCCGCCGCCAGC 2259 UCACC CGCGUUAUUGUUCUGCCGGGCGGACACGUGACGCGAAGCUUUAUAAAACCCGGCGGCGCA ACGCGCAGCCACUGUCGAGUCGCGUCCACCCGCGAGCACAGCUUCUUUGCAGCUCCUUCG 2260UUGCCGGUCCACACCCGCCACCAGUUCGCCCCAttorney Docket No.: 62801.85WO01CGCGUUAUUGUUCUGCCGGGCGGACACGUGACGCGAAGCUUGGCGAACUGGUGGCGGGUG UGGACCGGCAACGAAGGAGCUGCAAAGAAGCUGUGCUCGCGGGUGGACGCGACUCGACAG 2261 UGGCUGCGCGUUGCGCCGCCGGGUUUUAUACC CGCGUUAUUGUUCUGCCGGGCGGACACGUGACGCGAAGCUUGGGAAAUAAGAGAGAAAAG AAGAGUAAGAAGAAAUAUAAGAGCCACCUAUAAAACCCGGCGGCGCAACGCGCAGCCACU GUCGAGUCGCGUCCACCCGCGAGCACAGCUUCUUUGCAGCUCCUUCGUUGCCGGUCCACA 2262 CCCGCCACCAGUUCGCCCC GGCUCUGAAAAAAAAAAAAAACCGACAUUUGCUUCUGACACAACUGUGUUCACUAGCAAC CUCAAACAGACACC 2263 GGCUCUGAAAAAAAAAAAAAACCGGGACCCAAGCUAGCUAGCGUUUAAACUUAAGCUAGG UACCGGGACC 2264 GGGCUUUUCGCCUUUAGGGGGUUCUCAUUAUAUAAAGAUGACAACACCAGUAGGAAAACA AGUCAGUAAGUAAACGAGCAAAAGAAGAAGAGAAACAACAAGAAGUAGUA 2265 CUUUCCCCGUUCUCUUCGGUUCUCAUCGCUGUGAGUGUGCUGGGCAGGUGCGGACGCCAG AGCCGAGCCCGCGUCGCC 2266 AGCGAGGCUGCUGUGGUCUACACGACUCUCUGAGCUUCGCC 2267 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACUAGGAGUGUUC UGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2268 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACUAGAGGAGUCG GGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2269 AGGAGUGUUCUGCACCCCAUCUCUUUUGCGGUUUGAGAUUUAGCCUGACU 2270 AGGAGUGUUCUGCACCCGAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2271 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCGUGACU 2272 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGGCUGACU 2273 AGGAGUGUUCUGCACCGCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2274 AGGAGUGUUCUGCAGCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2275 AGGAGUGUUCUGGACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2276 AGGAGUGUUCUGCACCCCAUCUCUUUCCCGGUUUGAGAUUUAGCCUGGCU 2277 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGCUUGAGAUUUAGCCUGACU 2278 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUCUGAGAUUUGGCCUGACU 2279 AGGAGCGUUCUGCGCCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2280 AGGAGUGCUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2281 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACUAGGAGAAUAA ACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCC 2282 AGAC C C AAGC UAGC UAGC GUUUAAAC UUAAGC UAGGUAC C GGGAC C 2283 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAAAGGAGUGUUC UGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2284 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAAAGAGGAGUCG GGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2285 AGCGGAGUCGGGUUUUACAGCCGCAACGUUAUCCGCGACAAACACAGGAA 2286 AGAGGCGUCGGGUUUUACAGCCGCAACGUUAGCCUCGACAAACACAGGAA 2287 AGAGGAGUGGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2288 AGAGGAGUCGGGUUUUACAGCCGCAAGGUUAUCCUCGACAAACACAGGAA 2289 AGAGGAGUCGGGUUUUACAGCGGCAACGUUAUCCUCGACAAACACAGGAA 2290 AGAGGAGUCGGGUUUUACAGGCGCAACGUUAUCCUCGACAAACACAGGAA 2291 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUGGACAAACACAGGAA 2292 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCGUCGACAAACACAGGAA 2293 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUGCUCGACAAACACAGGAA 2294 AGAGGAGUCGGGCUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2295 AGAGGAGUCGGGUCUUACGGCCGCAACGUUAUCCUCGACAAACACAGGAA 2296 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAAAGGAGAAUAA2297ACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCAttorney Docket No.: 62801.85WO01GGUAAUCUGCAAAUCCCUGGCACCCGCCUAAAAUUGCCCUCAUCAACCUUCUCUCUAUUC ACG 2298 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGC C AC CCGCCUCGCCGCCU CCACAUUUGCUUCUGACACAACUGUGUUCACUAGCAACCUCAAACAGACACC 2299 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGCCACCCGCGUUAUUGUUC UGCCGGGCGGACACGUGACGCGAAGCUUUAUAAAACCCGGCGGCGCAACGCGCAGCCACU GUCGAGUCGCGUCCACCCGCGAGCACAGCUUCUUUGCAGCUCCUUCGUUGCCGGUCCACA 2300 CCCGCCACCAGUUCGCCCC GUAUUUUUACAACAAUUACCAACAACAACAAACAACAAACAACAUUACAAUUACUAUUUA CAAUUACA 2301 CUUCCUUUUGUACAUUUGCUUCUGACACAACUGUGUUCACUAGCAACCUCAAACAGACACC 2302 CUCAGCCCGUAGCCCGUCGGUUCCGGAGUAAGUUCCAGGUGGCCCAGCAGUGGGUGUGGA AGGGGAGGAUCAUCAGACCCACUGACACAGACCCAAGACAGCAAGAAGCUAACCAGGCAC 2303 C AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCAGGAGUGUUC UGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2304 AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCAGAGGAGUCG GGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2305 AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCAGGAGAAUAA ACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCC 2306 AGGAGGCGGGUCCCCUGGUCCACAACAGAAGCAUUGCUAAAGCAGCAGAUAGCUCAGGGA CCCACAGAGCCCUUGUCCUUCCACA 2307 UGCGUCACCUGACCGCAUUCUGCACCUCAACUCUCC 2308 GCUAGGGCGGGAUGGGACGGCCGGUUACUUAAAGGUUGGGGCGACCAAGGGUCCGCGGCC GCAGCCUGGGUCCUCACCGUCGCC 2309 CGUCCGGGGCGGAAGGGGCCAGAAGCGAGUCAGGCGGCGCGUCUCGGGCCCGCGGAAGGG GAGCGAGAGCUGUCUGACCCGGCAGAGGCG 2310 CAAGGAUCAGAGUUCGGGGGCUGAGGGCUCAGACGUUCUUCUCUGCCCUCUCCACC 2311 AUAUCCCCCUUGGCUCCCACUGCUUAAAUACAGACUAGGACAGGGCUCUGUCUCCUCAGC CUCGGUCACCACCCAGCUCUGGGACAGCAAGCUGAAA 2312 AGACUGAGUAGCGUUGUCGAUUGCUGUUUUCAUAACGACAAACACAGGAA 2313 AGAGGAGUCGGGGUUGUCGAUUGCAACGUUAUCCUCCGUACCGAGCCUGC 2314 AGAGGAGUCGGGGUUGUCGAUUGCAACGUUAUCCUCGACAAACACAGGAA 2315 AGAGGAGUCGGGUUUUACAGCCGCUGUUUUCAUAACCGUACCGAGCCUGC 2316 AGAGGAGUCGGGUUUUACAGCCGCUGUUUUCAUAACGACAAACACAGGAA 2317 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCCGUACCGAGCCUGC 2318 AGACUGAGUAGCGUUGUCGAUUGCUGUUUUCAUAACCUCAGAGAGAACCC 2319 AGACUGAGUAGCGUUGUCGAUUGCGGUCCCCACAGACGUACCGAGCCUGC 2320 AGACUGAGUAGCGUUGUCGAUUGCGGUCCCCACAGACUCAGAGAGAACCC 2321 AGACUGAGUAGCUAGUAUUCUUCUUGUUUUCAUAACCGUACCGAGCCUGC 2322 AGACUGAGUAGCGUUGUCGAUUGCAACGUUAUCCUCCGUACCGAGCCUGC 2323 AGACUGAGUAGCUAGUAUUCUUCUUGUUUUCAUAACCUCAGAGAGAACCC 2324 AGACUGAGUAGCUAGUAUUCUUCUGGUCCCCACAGACGUACCGAGCCUGC 2325 AGACUGAGUAGCUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCC 2326 AGGAGAAUAAACGUUGUCGAUUGCUGUUUUCAUAACCGUACCGAGCCUGC 2327 AGGAGAAUAAACGUUGUCGAUUGCUGUUUUCAUAACCUCAGAGAGAACCC 2328 AGGAGAAUAAACGUUGUCGAUUGCGGUCCCCACAGACGUACCGAGCCUGC 2329 AGGAGAAUAAACGUUGUCGAUUGCGGUCCCCACAGACUCAGAGAGAACCC 2330 AGGAGAAUAAACUAGUAUUCUUCUUGUUUUCAUAACCGUACCGAGCCUGC 2331 AGGAGAAUAAACUAGUAUUCUUCUUGUUUUCAUAACCUCAGAGAGAACCC 2332AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACGUACCGAGCCUGC 2333Attorney Docket No.: 62801.85WO01AGACUGAGUAGCGUUGUCGAUUGCAACGUUAUCCUCGACAAACACAGGAA 2334 AGACUGAGUAGCGUUGUCGAUUGCUGUUUUCAUAACGAUUUAGCCUGACU 2335 AGACUGAGUAGCGUUGUCGAUUGCUUUCCGGUUUGACGUACCGAGCCUGC 2336 AGACUGAGUAGCGUUGUCGAUUGCUUUCCGGUUUGAGAUUUAGCCUGACU 2337 AGACUGAGUAGCCACCCCAUCUCUUGUUUUCAUAACCGUACCGAGCCUGC 2338 AGACUGAGUAGCCACCCCAUCUCUUGUUUUCAUAACGAUUUAGCCUGACU 2339 AGACUGAGUAGCCACCCCAUCUCUUUUCCGGUUUGACGUACCGAGCCUGC 2340 AGACUGAGUAGCCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2341 AGGAGUGUUCUGGUUGUCGAUUGCUGUUUUCAUAACCGUACCGAGCCUGC 2342 AGGAGUGUUCUGGUUGUCGAUUGCUGUUUUCAUAACGAUUUAGCCUGACU 2343 AGACUGAGUAGCUUUUACAGCCGCUGUUUUCAUAACCGUACCGAGCCUGC 2344 AGGAGUGUUCUGGUUGUCGAUUGCUUUCCGGUUUGACGUACCGAGCCUGC 2345 AGGAGUGUUCUGGUUGUCGAUUGCUUUCCGGUUUGAGAUUUAGCCUGACU 2346 AGGAGUGUUCUGCACCCCAUCUCUUGUUUUCAUAACCGUACCGAGCCUGC 2347 AGGAGUGUUCUGCACCCCAUCUCUUGUUUUCAUAACGAUUUAGCCUGACU 2348 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGACGUACCGAGCCUGC 2349 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCCUCAGAGAGAACCC 2350 AGAGGAGUCGGGUUUUACAGCCGCGGUCCCCACAGAGACAAACACAGGAA 2351 AGAGGAGUCGGGUUUUACAGCCGCGGUCCCCACAGACUCAGAGAGAACCC 2352 AGAGGAGUCGGGUAGUAUUCUUCUAACGUUAUCCUCGACAAACACAGGAA 2353 AGACUGAGUAGCUUUUACAGCCGCUGUUUUCAUAACGACAAACACAGGAA 2354 AGAGGAGUCGGGUAGUAUUCUUCUAACGUUAUCCUCCUCAGAGAGAACCC 2355 AGAGGAGUCGGGUAGUAUUCUUCUGGUCCCCACAGAGACAAACACAGGAA 2356 AGAGGAGUCGGGUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCC 2357 AGGAGAAUAAACUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2358 AGGAGAAUAAACUUUUACAGCCGCAACGUUAUCCUCCUCAGAGAGAACCC 2359 AGGAGAAUAAACUUUUACAGCCGCGGUCCCCACAGAGACAAACACAGGAA 2360 AGGAGAAUAAACUUUUACAGCCGCGGUCCCCACAGACUCAGAGAGAACCC 2361 AGGAGAAUAAACUAGUAUUCUUCUAACGUUAUCCUCGACAAACACAGGAA 2362 AGGAGAAUAAACUAGUAUUCUUCUAACGUUAUCCUCCUCAGAGAGAACCC 2363 AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGAGACAAACACAGGAA 2364 AGACUGAGUAGCUUUUACAGCCGCAACGUUAUCCUCCGUACCGAGCCUGC 2365 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGAUUUAGCCUGACU 2366 AGAGGAGUCGGGUUUUACAGCCGCUUUCCGGUUUGAGACAAACACAGGAA 2367 AGAGGAGUCGGGUUUUACAGCCGCUUUCCGGUUUGAGAUUUAGCCUGACU 2368 AGAGGAGUCGGGCACCCCAUCUCUAACGUUAUCCUCGACAAACACAGGAA 2369 AGAGGAGUCGGGCACCCCAUCUCUAACGUUAUCCUCGAUUUAGCCUGACU 2370 AGAGGAGUCGGGCACCCCAUCUCUUUUCCGGUUUGAGACAAACACAGGAA 2371 AGAGGAGUCGGGCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2372 AGGAGUGUUCUGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2373 AGGAGUGUUCUGUUUUACAGCCGCAACGUUAUCCUCGAUUUAGCCUGACU 2374 AGGAGUGUUCUGUUUUACAGCCGCUUUCCGGUUUGAGACAAACACAGGAA 2375 AGACUGAGUAGCUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2376 AGGAGUGUUCUGUUUUACAGCCGCUUUCCGGUUUGAGAUUUAGCCUGACU 2377 AGGAGUGUUCUGCACCCCAUCUCUAACGUUAUCCUCGACAAACACAGGAA 2378 AGGAGUGUUCUGCACCCCAUCUCUAACGUUAUCCUCGAUUUAGCCUGACU 2379 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGAGACAAACACAGGAA 2380 AGGAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGAGAUUUAGCCUGACU 2381AGGAGAAUAAACUAGUAUUCUUCUUUUCCGGUUUGACUCAGAGAGAACCC 2382Attorney Docket No.: 62801.85WO01AGGAGAAUAAACUAGUAUUCUUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2383 AGGAGAAUAAACCACCCCAUCUCUGGUCCCCACAGACUCAGAGAGAACCC 2384 AGGAGAAUAAACCACCCCAUCUCUGGUCCCCACAGAGAUUUAGCCUGACU 2385 AGGAGAAUAAACCACCCCAUCUCUUUUCCGGUUUGACUCAGAGAGAACCC 2386 AGAGGAGUCGGGGUUGUCGAUUGCUGUUUUCAUAACCGUACCGAGCCUGC 2387 AGGAGAAUAAACCACCCCAUCUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2388 AGGAGUGUUCUGUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCC 2389 AGGAGUGUUCUGUAGUAUUCUUCUGGUCCCCACAGAGAUUUAGCCUGACU 2390 AGGAGUGUUCUGUAGUAUUCUUCUUUUCCGGUUUGACUCAGAGAGAACCC 2391 AGGAGUGUUCUGUAGUAUUCUUCUUUUCCGGUUUGAGAUUUAGCCUGACU 2392 AGGAGUGUUCUGCACCCCAUCUCUGGUCCCCACAGACUCAGAGAGAACCC 2393 AGGAGUGUUCUGCACCCCAUCUCUGGUCCCCACAGAGAUUUAGCCUGACU 2394 AGGAGUGUUCUGCACCCCAUCUCUUUUCCGGUUUGACUCAGAGAGAACCC 2395 AGAGGAGUCGGGGUUGUCGAUUGCUGUUUUCAUAACGACAAACACAGGAA 2396 GUACUCUGGGUGACUCAGAGAGGGAAGAGAUUCAGCCAGCACACUCCUCGCGAGCAAGCA UUACUCUACUGACUGGCAGAGACAGGAGAGGUAG 2397 GGCCGGGCCGCGGACGGAAGCCGGAGGGCCGCGGCGAGAGCCGAGCGUUCUGGGGAGGGC C C GAC AC C C C C C GAGGAAGUGAAGC C GGC C C UGGC GC C GC GGC AAC 2398 GGGCCCGACGCCCCGGGAUCCCGGCCGCGCGCGGCGCUGCGGCGGGGUCCGGCGCGUGCG GCGCCGGGUCCGGCGGGGCCCGGCGCGCGUAAGCCGGCCAUCCGGGUUUCUCGGGCGAGA 2399 GCCGAGC GAUCCGGGCCGGAAGCGGCCGGAAGCGGGGCAGGCGGAGCGCGUCGGGCCCGCGGAAGGG GAGCGAGAGCUGUCUGACCCGGCAGGGGCG 2400 AGAGGAAUCCGGUUUUACCGACGAAACGUUAUCCUCGACAAACACAGGAA 2401 AGAGAAAUCCGGUUUUACCGACGAAACGUUAUCCUCGACAAACACAGGAA 2402 AGUUGAGUCGGUUUUCACAGCCGCGACGUUAUCCUCGACAAACACAGGAA 2403 AGAGGAACCGAGUCUUAAAGGAGCAACGUUAUCCGCGACAAACACAGGAA 2404 AAAGGAGUGAGGUUUUACCGACUCAACGUUAUCCUCGACAAACACAGGAA 2405 AGAGGAAUCAGUGAGUACAGCCACAACGUUAUCCUCGACAAACACAGGAA 2406 AGAGGAGUCAGGUUUUACCGACGAAACGUUAUCCGCGAUAAAGACAGGAA 2407 AGGAGAGUCAGGUUUUACAGACCGAACGUUAUCCUCGACAAACACAGCAA 2408 AGAGAAGUUGGGUUUGACAGACCGAACGUUAUCCUCGACAAACACAGCAA 2409 AGAGGAAUCGAGUUUUUCAGACGAAACGUUAUCCUCGACAAACACAGGAA 2410 AGGAGAGUCAGGUUUUACAGUCACCACGUUAUCCGCGACGAACACAGGAA 2411 AGAGGAGUCGGACUUUACAGACUCAACGUUAUCCGCGACAAACACAGGAA 2412 AGGAGAGUCAGGUUUUACCGACGAAACGUUAUCCUCGACAAACACAGGAA 2413 AGGAGAAUAAACUAGGACUCGUCUGAUCCCCACAGACUCAGAAAGUACCC 2414 AGAGGAAUCCGGUUUUACAGCCGCGACGUUAUCCUCGACAAACACAGGAA 2415 AGAGGAGUCGGGUUUUAAAGCCACAACGUUAUCCUCGACAAACACACGAA 2416 AGAGGAGUCAGGUUUUACAGACGCAACGUUAUCCUCGACAAACACAGGAA 2417 AGAGGAGUCGAGUUUUACAGCCGCGACGUUAUCCUCGACAAACACAGCAA 2418 AGAGGAGUCAGGUUUUACAGCCCCGACGUUAUCCGCGACAAACACAGGAA 2419 AGAGAAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAA 2420 AUAGGAGUCGACUUUUACAGCCCCGACGUUAUCCUCGACAAACACAGCGA 2421 AGUGGAGUCGGGUUUUACAGAUCCGACGUUAUCCUCGACAAACACACGAA 2422 AGAGGAAUCCGUUUUCACAGCCGCGACGUUAUCCUAAACAAAGAGAGGAA 2423 AGAGGAGUCGGGUUUUACGGCCGCAACGUUAUCCUCGACAAACACAGGAC 2424 AGGAGAAUAAAC UAGUAGUC UAC C GGAC C C C AC AGAC UC AGAGAGAAUC C 2425 AGAGGAGUCGAGUUUUACAGCCGCGACGUUAUCCUCGACAAAAACACGAA 2426AAAUAGACAGACUCAAUAAAAGUUUGACAGAACCCCAGAGAAAUAAAGUA 2427Attorney Docket No.: 62801.85WO01AGAGGAGUC GGAC UUCAAAGC C GC AAC GUUAUC C UC GAC AAAC AC AAGAC 2428 AGAGGAAUCCGGUUUUACGGCCGCAACGUUAUCCUCGACAAACACAGCGA 2429 AGAGGAGUCGGAUUUUACCGACGCAACGUUAUCCUCGACAAACACAGGAA 2430 AGUGGACUCGGGUUUUACGGCCGCGACGUUAUCCUCGACAAACACAGGAA 2431 AGAGGAGUCGGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACACGAA 2432 AGAGGAAUCCGGUUUUACGGCCGCGACGUUAUCCUCGACAAACACAGGAA 2433 AGAGGAGUCGACUUUUACGGCCGCGACGUUAUCCUCGACAAACACAGGAA 2434 AGAUGAGUCGGGUUUUAAAGCCACAACGUUAUCCGCGACAAACACAGGAA 2435 AGAGGAGUCAGGUUUUACAGACUCAACGUUAUCCUCGACAAACACAGGAA 2436 AGUGGAGUCGGGUUUUACAGAGCCAACGUUAUCCGCGACAAACACAGGAA 2437 AGAGGAGUCGGCUUUCAAAGCCGCAACGUUAUCCUCGACACACACAGGAA 2438 AGAGGAGUCAGGUUUUACCGACGCAACGUUAUCCUCGACAAACACAGGAC 2439 AGACUCAGUACCGCUGUCGAUUUCCGUUUUCAUAACCGUACCGAGUCUGC 2440 AGGAAAAUAAACUAGUAGACGUCUGGUCCCCAGAGACUCAGAGAGUACCC 2441 AGGAGUGAUCUACACGCCUUCUGUUUUCAGGUUUGACUUUUAGCCUGACG 2442 AGGAGAGUCAGGUUUUAGGACCGCGACGUUAUCCUCGACAAACACACGAA 2443 AGGCCAAUAAACUAGUAGACUUCUGGUCCCCAAAGACUCAAAGAGAACCC 2444 AGAGGAGUUGGGUUUUACGGCCGCAACGUUAUCCUCGACAAACACAGGAA 2445 AGAGGAGUCGAGUUUUACAACCGCGACGUUAUCCUCGACAAACACACGAA 2446 AGAGGAGUCGGGUUUUACAGCCGCGACGUUAUCCUCGACAAACACAGGAA 2447 AGAGGAGUCGACUUUUACGACCGCGACGUUAUCCUCGACAAACACAGGAC 2448 AGAGGAGUCGGAUUUAGCAGACUCAACGUUAUCCUCGACAAACACAGGAA 2449 AGAGGAGUCGGCUUUUACCGCCCGAACGUUAUCCUCGACAAACACAGCAA 2450 AGGAGAAUAAACUAGUGGCCCUGAGGUCCCCACAGACUCAGAGAGAACAC 2451 AGAGGAGUCGGCUUUUACAGACGCAACGUUCUCCUCGCCAAACACAAGAC 2452 AGAGGAGUCGGGUUUUAAAUCCCCAACGUUAUCCUCGACAAACACAGCGA 2453 AGAGGAGUCAGGUUUUACGACCGCAACGUUAUCCUCGACAAACACAGGAA 2454 AGAGGAGUCGGCUCUUAAAGCCAAAACGUUAUCCGCGACAAACACAGGAA 2455 AGGGGAGACGCGUUUUUCAGCCGGAACGUUAUCCUCGACAAACUCAGGAA 2456 AGACAGAGUUGCGUUGUCGUUUUCUGUUUUCAGAUCCGUACCGAGCCGAC 2457 AGGAGAACAGACUAGUAUUCUUCCGGUCCCCACAGACUCAAAGACAACCC 2458 AGCAGAAUAAACUAGUAGACUUCCGGACCCCUUAGACUCAAAGAGGACCC 2459 AGAGGAGUC GGAUAAAAAAGAC GC AAC GUUAUC C UC GAC AAAC UC AGGAA 2460 AGGAGAGUCCGCUUAUUCAACUGCUCCCACCUCAUCCAAACAGAAAGGAC 2461 AAAUAGAC C GAC UAAAUAGUAGUUUGAC C GUC GC C AAGAGAAAC AAAGAA 2462 AGAAGAGUCGGCUUUCAGAGCCACAACGUUAUCCUUUACAAACACAGCAA 2463 AGAUAGACCGACUCAAUAAAAGUUUGACCCCCUCCGAGAGAGAUAAAGUA 2464 AGGAGACUCCGGUUUUACGGCCGCGACGUUAUCCUCGACAAACACAGGAA 2465 AGAGAGGUCGAGUUUGUCAGCCGGAACGUUAUCAGAGACAAACACAGGAA 2466 AGGAGGGUUCUGAACCCGACCGCUUUUCUGUUUUGAUAUUUUGUCUGCCC 2467 AGGAUUGUUCUGCACGACAUCUCUUUUCCGGUUUGAGAUUAAGCACGACG 2468 AGGCGAAUAAACUAGAAUUCUUCUGGUCCCCAGAGACUGAGAGAGAACAC 2469 AGGAGACUAAACUAAUACUCGUCUGGUCCCCACUGACUCAGAGAGAACCC 2470 AGGAGAGUCCGGUUUUACGGCCGCGACGUUAUCCUCGACAAACACAGGAA 2471 AGAGAAGUCGAGUUUUACAGCCGGAACGUUAUCCUCGACAAACACAGGAA 2472 AGGAGAGUCAGGUUUUACGGCCGCGACGUUAUCCUCCAAAAACACAGGAA 2473 AGACUGAGUUGCGUUGUCGAUUGCUGUUUUCAUAACCGUACCGAGCCUGC 2474 AGACUGAGUAGCGUUGUCGAUUGCUCUUUUCAUAACCGUACAGAGCCGGC 2475AGAUUUCGAAGUAGGUGUGAAAGUCAGCGUUGGCCUCAGAGACGACGGAGAG 2476Attorney Docket No.: 62801.85WO01972 AGUUUUGCAAGUUGGUGACAAAGGCAGCGUUGGCAACAGAGGACGAGGAAAG 2477 973 GGGAAAUCCGAGCGAAAAGAAGAGUCAGAGGAAAUAUAAGA 2478 974 AGAGGAAUCAGAUGUUUCAGCCACAACGUUAUCCGCGACAAACACACGAA 2479 975 AGCGAGCAAGAUUUCGAUUCCUCAUCGAACUGCGAGUCAUAACCAGAGCC 2480 976 AGAGCAGUACAGUUUUAAAGCUUCAGCGCUUUCCGCGACGAAGCCAGGAA 2481 977 AGAUUAGUACCCUUUUACACCUGCAGCGCUUUCCGCGACCAAGACAGGAC 2482 978 AGAGUAGUAC AC UUUUGC AAC UGC AC C GC AAUC C GC GAC GAAGC C AGGAU 2483 979 AGCGACCAAGACUUCGAUACCUCAUAGAACUGGGAGUCAUCAUCAGGGCC 2484 980 AGCGACGAAGAGUUCCAUACCUCAUCGAGCUUCGAGUCAUAAGCAAGGCC 2485 981 CAGAUCGCCUAGAGACGCCACCCAAACUGUUUUGACUUCCAU 2486 982 CAGAUUGCCUAGAGACGCCCUCCACGCAGUUUUGACUUCCAU 2487 983 AGGAGUAGUCUGCACCCGAUCCCUUUUGAGCGUUGAUAUUUACUCCUACU 2488 984 AGGACCGUCAUAUUAUUUAUCUUGCAGAUCAAACUUCGGAGAGGAGCGAC 2489 985 AGGAGGACAAACUACUAUUCGUCGGGUCCCCAGAGACUCAGAAAGUACCC 2490 986 ACGGAUCAGGAGUUCGAUACCUCAUCGAACUGCGAGUCACAACCAAGGCU 2491 987 AGUCUUGUUUCCUUUUUAAAGCUUUCACACCUCAUCCUACCUUCGACGAC 2492 988 AGUCUUGUUUCCUUUUUAAAGCUUUCACUCCUGACCCUACCUACGACGAC 2493 989 AGAGCAGUCGGGUGAAACAGACGCGACGUUAUCCUCGACGAACUCAAGAA 2494 990 AGGAGUGAGCUGCACUCCAUCUGUUUUCAGCUUGGAUAUUUAGUCUCAGU 2495 991 AGGUUCGUUACACUAUUUAACUCGCAGAUCAAACUUCAGAGAGGAGAGUC 2496 992 AGGAGGACAAACUACUAUUCGUCUGGUCCCCAGAGACUCAGAAAGUACCC 2497 993 AGCGACCAAGAGUUCGAUACCUCAUCCAACUGCGAGUCAUAACCAGAGCC 2498 994 AGCCUUAUUUCCUUUUUUUAACUCCUACCCCUCUACCUACCCGCGACGAC 2499 995 AGAGGAGUUGGAACUUACAGGCUCGACGUUAAACUCGACGAAAACACGAA 2500 996 AGGCGUGUUUAGUUAUUCGAGUUCCGACACCUCUUCCGACAAACAACGAG 2501 997 AGAGUAGUACCGUCUUACAACUGCAGCCCUAUACGCGACGGAGACAGGAU 2502 998 AGGGGUGUUCUGCAUCCGAUCUCUUUUCAUAUUUGAGGUUUAGCCCCACU 2503 999 AGACUUGUUUCCGUUUUAAAAAUCCGACAGCUGAUCCCACCAUCGACGAC 2504 1000 CAGAUCGCCUAGAGACGCCAGCCACGUUGUUUUGAACUCCAU 2505 1001 AGAGGAGUCGAGUUACACAGCCGCAACGUUAUCCUCGACGAACAAAGGAA 2506 1002 ACAGGUGUCCGGUUUUACAGCAGCGACGUUAUCCUCGACAAACACAGGAA 2507 1003 AGAGGAGUCGAGUUAAACAGACGCAACGUCAUCCUCGACGAACACAGAAU 2508 1004 AGGAAAAAAGAGAGAAAAGGAGAUGAAGAAGAGAGAGAGGA 2509 1005 AGGAGAAUAAACUAGUAUUCUUCUGGACCCCUCAGACUCAGAGAGGACCC 2510 1006 AGGAGUCUGCUGAACAUCAGCUUUUAUCCGGUUUUAGAUUCAGUCUGACU 2511 1007 AGUGGAGACGAGUUAAACAGACCGAACGUUAUCCUCGACGAACACAAGAA 2512 1008 AGGCGUGUUUACUUAUUCAGAUUCCCAAACCUCAUCCAACAAGCAACGAC 2513 1009 AGACUUGUUUCCUUUUUCAAAAUCCCAGAUCUCAUCCUACCUGAAAAGAC 2514 1010 AGAGUGGUAGAGUUUUACAACAGCAACGUUAUCCGCGACGAAGAGAGGAA 2515 1011 AGCUUAGUUUCCGUUUUUUAAAUCCCAGAACUCAUCCGAGCAGCGACGAC 2516 1012 AGACGAGUUGACUUUUACUCCGUCAAAGCUCUCAGCCAAACAGACAAAAU 2517 1013 CAGAUCGCCUAGAGACGCCAUCCAAUCAGUUUUGACUUCCAU 2518 1014 AGAGGAGUCGAGUUACACAGCCGCAAGGCUAUCCUCGACGAACUCAGGAA 2519 1015 AGGAGAGUCAGGUUUUACAGCCGCAACGUUAUCCUCGACAAACACAGGAC 2520 1016 AGAGAAAUCGAGUCACACAGCCGCAACGUUAUCCUCGACGAACUGAGGAA 2521 1017 ACGAAGAAAGAGACAAAAGGAGAGGAAGGAAAAAUAGAAGA 2522 1018 AGGAGAAUAAACUUGUUUACUUUUGGUCCCCACAGACUGUGAGACAUCCC 2523 1019 AGGAGUCGUCUGCUCUUCAUCCCUUUUCUGGUUUGAGCUUCAGCCAGACU 25241020 AGGCUUGUUUACUUUUUCAAAUUCCCAGACCCCAUCCCACAAGCAGCGAC 2525Attorney Docket No.: 62801.85WO011021 AGCGACCAAGAGUUCGAAAAAUCAUCGAACUGCGAGUCAUAAACACAGAC 2526 1022 AGGUCCGUCAUAUUAUUUAUCUUGCAGACCAAACUUCAGAGAGGAGAUCC 2527 1023 AGGCUUGUUUCCUUUUUCCGAAUCCCAGAUCUCAUCCUAUCUGAAAAGAC 2528 1024 AGAUUAGUUGAGUUUUAAAACUCCACCGCUUUCCGCGACGAAGUCAGGAA 2529 1025 AGACGCGUUGACUUUUAGUACCGCAACGUUCACAUCCAGGAAGCUAAGAC 2530 1026 AGAGGAAUCCGGUUUUACAGCCCCGACGUUGUCAUCGACAAACACACGAA 2531 1027 CAGAUCUCCUGUAGACGCCAUCCAAGCAGUUUUGACCUCCAG 2532 1028 AGAGGAGUCGAGUUAAACAGCCGCAACGCUAUCCUCGACGAACACAGGAA 2533 1029 AGAGAAGUCGGGUUUUACAGCCGCGACGUUAUCCUCGACAAACACAGGAA 2534 1030 GAGAAAUUAGAGAUAAAAGAAGAGUAAGAAGAAAUAGAAGA 2535 1031 AGGAGACUAAACUAGUAUUCUUCUGGACCCCGGAGACUCAGAGAGGACCC 2536 1032 AGGAGUGUUCUGCUCCGCAUCUUCUAUCCGGUUAGACUUUUAGCCUCAGA 2537 1033 AGGGACCAGGAGUUCGAUACCUCAUCGAACUGCGAGUCAUAACCAGGGCC 2538 1034 AGAGGAGUCGAGCUUAACGAACCGAACGUUAUCCUCGACAAACACACGAA 2539 1035 AGAGUAGUUGAGUUUUACAACUGCAGCGUCAUCCGCGACGACGACAGGAA 2540 1036 AGCCUUGUUUCCUUUUUAAAAUUCCCACACCUCAUCCUACCUGCGACGAC 2541 1037 AGACGAGUUGAAUUUCACAACCGCAACGCUCUCAUCCACGCAGAAAGAAC 2542 1038 AUAGGAGUUGAGUCACACAGCCGCAACCCUAUCCUCGACGAACACAAGAA 2543 1039 AGAGGAAUC GAGUGAC AAAGC C GC AAGGC UAUC C UC GAC GAAC UGAGGAA 2544 1040 AGGCUUGUUUCCGUUUUCAGAUCCGCACACCUCAGCCAACAAUCAAAGAC 2545 1041 AGAGGCGUUGACUUUUAUAACCGCGACUCUCUCAUCCCAGCAGAGAGGAC 2546 1042 AGACGCGUUGAUUGUUAAAUCCGCAAGGCUUUCAUCGACGCACACAGAAC 2547 1043 AGGAGUGAUCUGCAACAAAACCCUUUUCAGGUUUGAGAGUUUCCCAGACU 2548 1044 AGGAGAGUUUUGCACACCAGCUCGUUUCCGGUUGGAGAUCGAGCUUGAGU 2549 1045 AGACUUGUUUCCUUUUUUAAAAUCCCAGAUCUCAUCAAACCUGAACAGAC 2550 1046 AGACUUGUUUCCUUUUACAAAAUCCCAGAUCUCAUCCUACCUGGAAAGAC 2551 1047 AGAGGAGUUGGGUC AU AC CGCCGCAACCC UAUC C UC GAC GAAC AC AAGAA 2552 1048 AGAGGAGUCGAGUUAUACAGAAGCAAGGCUAUCCUCGACGAACAAAGGAU 2553 1049 AGCCGUUUUUCCCUUUUCAAAAUCCCAGAACUUGUCGUCCCAAAGCCGAC 2554 1050 AGACUUGUUUCCUUUUUUAAAAUCCCAGAUCUCAUCCCAGCAGCGACGAC 2555 1051 AGGCGCGUUUACUGAUUCCGAUUCUCACACCACAUCCAAGAAGCAACGAA 2556 1052 AGAGGAAUCGAGUUUUCCCCCAGCAACGUUAUCCUCCACAAACACAGGAA 2557 1053 AGAGGAAUCCGGUUUUACAGCCGCAACGUUAUCCUCCACAAACACAGGAA 2558 1054 AGGACCGUUAUAUUAUUUAUCUUGCAGAUCAAAGUUCAGAGAGGAGGCCC 2559 1055 AGGUUCGUUACAUUAGUUUUCUUGCAGAUCAAAGUUCAGAGAGUAGGACG 2560 1056 AGGAGAUAAAGGAGCAAAGCAGAGAAAGUAGACAUAUAAGA 2561 1057 AGGAAAAAGGAGACAAAAGAAGAUUAAGAAGCAAUAUUAGA 2562 1058 AGGUGAAUAAACAAUUAUUCUUUUGUUCCCCACAGACUCCGAGAGUACCC 2563 1059 AGGUGAAUAAACAAGUUUUCUUUUGGACCCCACAGACACAGAGAUAACAC 2564 1060 AGGUGUGUUUACUUAUUCAAAAUCCCUCACCCCAUCCAAAAAGCACCGAC 2565 1061 AGUCGUGUUGACUUAUUCAGAUUCCCAAAACUCAUCCCACAAGCAAAGAC 2566 1062 AAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2567 1063 UCUCUUAUUACCUGUUUCACAAUACCAUACAUCAUCCUACCUGCUACGCU 2568 1064 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2569 1065 UCUCUUGUUUCCUUUUUCAAAAACCCGUACCUCAUCCUCUCUGCAACGCC 2570 1066 ACUCUUUUUUCCUUUUUCAAAAUCCUGUACCCCAUCCAUCCUGCAACGCC 2571 1067 GAUACGCUUGGCCACCUUUCUACCGGAGUAGUGCAUAAUGAGGCGAGAGC 2572 1068 AUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 25731069 AAUCUUGUUUCCUGUUUCAAAAUCGCAUACCUCAUCCUUACUGCGACGCC 2574Attorney Docket No.: 62801.85WO011070 UUAGGGCUUCAAAGGUACAAAUUAAAAUACCCCCCUCUUCCUGAGACGCC 2575 1071 AUUCUUGUUUCCUUCUUCAAAAUCCCAUACCUCAUCCUUCCUGCAUCUCC 2576 1072 AUUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2577 1073 AAUCUUGUUUCCUUAUUCUAAAUACCUUCCCUCAUCGUUCCUCCAACUAA 2578 1074 AUUCUUGUUACGUUUUUCUAAAUCCCACACCUCAUUGUUCCUGCGACGCU 2579 1023 AGGAAUUGCACAUCCGUUAAAGUAACAAAAUUGGCAGAUUUUGAAUUGCA 2580 1076 AAUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2581 1077 AACCUUGUUUCCUUUUUAAAAAUCCCACACCUCAUCCUACCUGCAAAGAC 2582 1078 UAUCCAGUUUCCGUAUUAACAAUCCCACAUCUCGUCCUCCGUCCGACGCU 2583 1079 UUAAAGGACGGUGGGGCCACAAGACCCUAGACUAAUUCGGUUAAUAUAUU 2584 1080 AAUCUUCUUUCCUUUGAUAAAAUCCCUGACCUCAUCGUUCAUACGACGCC 2585 1081 AAUCUUGUUUCCUUGUCCAAAAUCUCACACCUCAUCCUUCCUGCGAGACC 2586 1082 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUGUUAAAAGACGAG 2587 1083 CGCCGGACUUUAAUUUCUGGAAGUGAAUAAGACUUCUGUUAAAAGACGAG 2588 1084 UAUCUUAUUUCCUUUUUCAGAAUUCCAUACUUCAUCCUAACUGCGACGUC 2589 1085 UGCCGGACGUUAAUUUCUUGAAGUGAAUGAAACUUCUGUUAAAAGACGAG 2590 1086 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2591 1087 ACUGUUGUUUACUUAUUCAAAAUCGCACACCUCAUCGUACUUGCGACGCU 2592 1088 ACUCCUAUUUCCUUUUUCAAAAUCCCAUACUUCAUCCUACCUGCGAAUCG 2593 1089 UGUCUUGUUACCUUUUUACAAAUCCCAUCCCACAUCGUACUUGCAACCGA 2594 1090 AAUCUUGAUUCCUUAUUCAAAAUCCCAUAACUCAUCCUUACUGCGACGGA 2595 1091 UGUGUUGUUUCCUUUUUCAAAAUACCAUUCCUCAUUCAUACUGCAACGCU 2596 1092 ACUCUUGUUUCCUUCUUCAAAAUACCAUACCUCAUCCUAACUGCGACCCC 2597 1093 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAGCUCGUCCUUGCUCCGACGCC 2598 1094 ACUCUUGUUUCCUUUUUCAAAAUUCCAUACCUCAUUCUUCCUUCAACGUC 2599 1095 UAUCUUAUUUCCUUUUUCAAAAUCCCUUACCUCAUCUUUCCUGCCAGAGC 2600 1096 AUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCUAUACUGCAACGUC 2601 1097 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUAAAAAGACGAG 2602 1098 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2603 1099 AAAGCAUGCUGGAUACUAAAGGAGCUCUAUUGCAUCCUUAUGGCGUGCAG 2604 1100 UAACCAUGGAUGCUUUCACGGAGCCCGACGUUACAUUUAAUCGCGUAUGG 2605 1101 UCCAAUCUCUAUAUCCUAACAAACACUCUACACAAGGCAAUAAAACAUCA 2606 1102 UCUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGGAACGCC 2607 1103 ACUCUUGUUUCCUUUUUCAAAAUACCUUACCUCAUCCUUCCUGCAACGCC 2608 1104 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUCCAACGCU 2609 1105 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCGUUCUUGCAACGCC 2610 1106 UGUCUUAUUUCGUUCAUCCAAAUCCCUUAACUCAGCGAUCCUCCGACAUG 2611 1107 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUACUGCAAAGCC 2612 1108 ACUCUUGUUUCCUUUUUCAAAAUCCCUUACCUCAUCCUUACUGCAACGCC 2613 1109 ACUCUUGUUUCCUUUUUCAAUAUCCCGUACCUCAUCCUUCCUGCAACGUC 2614 1110 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCUUUCCUGCAACGCU 2615 1111 AAUCUUAUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2616 1112 ACUCAUAUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2617 1113 ACUCUUAUUUCCUUUGUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2618 1114 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCUUGCAACGAC 2619 1115 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAAGGUC 2620 1116 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCUUUCCUGCAACGCA 2621 1117 AUUCUUGUUUCCUUUUCCAGAAUACCUUACCUCAUCCUACCUCCGACGCC 26221118 UCACUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2623Attorney Docket No.: 62801.85WO011119 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAAAGUC 2624 1120 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACCCA 2625 1121 ACUGUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUCCAACGCC 2626 1122 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCAUCCCUGCAACGCC 2627 1123 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGGU 2628 1124 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACUUCAUCUUUCCUGCAACGCC 2629 1125 ACUCUUGUUUCCUUAUUCAAAAUCCCGUACCUCAUCUUUCCUGCAACGCC 2630 1126 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAAAGAC 2631 1127 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAAAGCU 2632 1128 AAUCUUUUUUCCUUUUUCAUUAUCCCUUACAUCAUCCCCACUGCGAAGCA 2633 1129 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCA 2634 1130 ACUCUUAUUUCCUUUUUCAAAAUCCCGUACCUCAUCUUUCCUGCAACGCC 2635 1131 UCUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGUC 2636 1132 UCUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCA 2637 1133 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCAUCCUGCAACGAC 2638 1134 UCUCUUGUUUCCUUUUCCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2639 1135 AGUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCGUUCCUGCAACGCC 2640 1136 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCGUACCUGCAACGCC 2641 1137 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUACUGCAACGCC 2642 1138 ACUCUUAUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUACUGCAACGCC 2643 1139 ACUCUUAUUUCCUUUCUCAAAAUCCUAAAACUCAUCGUUCCUCCGACUCA 2644 1140 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACAUCAUCCUUCCUGCAACGCA 2645 1141 UCUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUACUGCAACGCC 2646 1142 ACUCUUGUUUCCUUUUUCAAAAUCCCUUACCUCAUCCAUCCUGCAACGCC 2647 1143 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACAUCAUCUUUCCUGCAACGCC 2648 1144 AGUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCA 2649 1145 UCUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCU 2650 1146 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUACUGCAACGCA 2651 1147 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCUUACCUGCAACGCC 2652 1148 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCAUCCUGCAACGUC 2653 1149 UAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCAACGCC 2654 1150 AAUCUUGUUUCGUUUGCCAAAAUCCCGUACCUCAUCUAAACUGCAACGAU 2655 1151 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2656 1152 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2657 1153 ACUCUUGUUUCCUGUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2658 1154 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2659 1155 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGAC 2660 1156 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGUC 2661 1157 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACGCC 2662 1158 ACUCUUGUUUCCUUUCUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2663 1159 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCC 2664 1160 ACUCUUGUUUCCUUUUUCAGAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2665 1161 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2666 1162 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGUU 2667 1163 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2668 1164 ACUCUUAUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCC 2669 1165 ACUCUUGUUUCCUCUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCA 2670 1166 ACUCUUGUUUCCUUUCUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACGCC 26711167 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCC 2672Attorney Docket No.: 62801.85WO011168 ACUCUUGUUUCCAUUUUCGAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2673 1169 ACUCUUGUUUACUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCA 2674 1170 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGUC 2675 1171 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGUC 2676 1172 UCUCUUGUUUCCUGUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2677 1173 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCU 2678 1174 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2679 1175 ACUCUUGUUUCCUUUCUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2680 1176 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGAU 2681 1177 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGAG 2682 1178 ACUCUUGUUUCCUUUUCCAAAAUCCCAUACCUCAUCCUUCCUGCGACGUC 2683 1179 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACGCC 2684 1180 UCUCUUGUAUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2685 1181 UCUCUUGUUUCCUUUUUCAGAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2686 1182 AAUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACGCC 2687 1183 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGAC 2688 1184 ACUCUUGUUUACUUUUUCAAAAUCCCAUACCUGAUCCUUCCUGCGACGCC 2689 1185 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2690 1186 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGUC 2691 1187 UCUCUUGUUUCCUCUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2692 1188 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGAC 2693 1189 ACUCUUGUUUCCUAUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCC 2694 1190 UCUCUUGUGUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2695 1191 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2696 1192 ACUCUUGUUUCCUCUUUCAGAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2697 1193 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACGUC 2698 1194 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGGU 2699 1195 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAGCUCAUCCUUCCUACGACGCC 2700 1196 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2701 1197 GCUCUUGUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCC 2702 1198 UCUCUUGUUUCGUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2703 1199 ACUCUUGUAUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGUC 2704 1200 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUGAUCCUUCCUGCGACGUC 2705 1201 ACUCUUGUUACCUUUUUCUAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2706 1202 UCUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACGCC 2707 1203 ACUCUUGAUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGAC 2708 1204 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCGUUCCUGCGACGCC 2709 1205 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCA 2710 1206 ACGCUUGUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCC 2711 1207 UUCCCUUAGGACUUAUAUCUUUCAGAUCCCACAUCGUUUCCCAAUUGGAG 2712 1208 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAUCUCAUCCUUCCUGCGACACC 2713 1209 ACUCUUGUUUCGUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCA 2714 1210 ACUCUUGUUUCCUUUCUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCA 2715 1211 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGUCGCC 2716 1212 ACUCUUGUUUCCUCUUCCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2717 1213 ACUCUUGUUUCCUCUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCU 2718 1214 ACCCUUGUUUCCUCUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2719 1215 ACUCUUGUUUCCUUUUUCAAAAUCCCAUAACUCAUCCUUCCUGCGACGCA 27201216 ACUCUUGUUUCCUGUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2721Attorney Docket No.: 62801.85WO011217 UCUCUUGUUUCCUAUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2722 1218 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2723 1219 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGAGGCC 2724 1220 ACUCUUGUUUCCUUUUUCAGAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2725 1221 UCUCUUGAUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2726 1222 ACUCUUGAUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGGC 2727 1223 UCUCUUGUUCCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2728 1224 ACUCUUGUAUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCA 2729 1225 AAAGCAUGUUGGCGUCUCAAGGAGUUCUCAUGCAUCCUUAUGGCGUGCCU 2730 1226 AAAGCAUGCUGGCGUCUCAAGGAGUUCUUAUGCAUCCUUAUGGCGUGCCU 2731 1227 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCAUGCAUCCUUAUGGCGUACCU 2732 1228 AAAGCAUGCUGGCGUCUCAAGGAGUUGUCAUGCAUCCUUAUGGCGUGCCU 2733 1229 UGCCGGACUUUAAUUUUCGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2734 1230 AAAGCAUGCUGGCGACUCAAGGAGUUCUCAUGCAUCCUUAUGGCGUGCCU 2735 1231 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCAUGCAUCCUUAUGGCGUGCCU 2736 1232 AAAGCAUGCUGGCGUCUCAAGGUGUUCUCAUGCAUCCUUAUGGCGUGCCU 2737 1233 AAAGCAUGCUGGCGUCACAAGGAGUUCUCAUGCAUCCUUAUGGCGUGCCU 2738 1234 AAAGCAUGCUGGCGUCUCAAGGAGUUCACAUGCAUCCUUAUGGCGUGCCU 2739 1235 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2740 1236 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2741 1237 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2742 1238 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2743 1239 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2744 1240 UUCCCUUAGAACUUAUAUCUUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 2745 1241 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2746 1242 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAC CCCGGCGCCGCCACC 2747 1243 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2748 1244 UCUCUUGUUACCUUUUUCAUAAUCCCACUCCUCAUCCUUCCUGCGACGUC 2749 1245 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2750 1246 ACUCUUCUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2751 1247 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAACCUUCCUACGACGCC 2752 1248 ACUCUUGUUUCUUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2753 1249 ACUCUUGUUUCCUUUUUGAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2754 1250 ACUCUUGUUUCCUUUUUCAAAAUCCCAAACCUCAUCCUUCCUGCGACGCA 2755 1251 ACUUUUGUUUCCUUUUUCAAAAUCCCAUUCCUCAUCCUUCCUGCGACGCU 2756 1252 ACUCUUGUUUCCUUUUUCAAACUCCCAUACCUCAUCCUUCCUGCGACGCC 2757 1253 ACUCUUCUUUCCUUGUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACCUC 2758 1254 ACUCUUGUGUCCUUUUUCCAAAUACCAUACCUCAUCGUUCCUGCGACGCC 2759 1255 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUUCUGCGACGCC 2760 1256 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2761 1257 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCGUUAUGGCGUGCCU 2762 1258 AAAGCAUGCUGGCGUCUCAAGGAGAUAUCCUGCAUCCUUAUGGCAUUCCU 2763 1259 AGUGGUUUACACUUGAAUGUUUGAAGAUCGCUACUUCAACUAUAUCGUCU 2764 1260 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCAU 2765 1261 AAAGCAUGCUGUCGUCUCAAGGAGUUCUUCUGCAUCCUUAUGGCGUGCCU 2766 1262 CUCGAACUCUUAGCUAUGCAGCAAGGCUUGAUACUAUAAAUGGGCCAAUA 2767 1263 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGUCU 2768 1264 AAAGCAUGCUGGCGUCUCAAGGAGUACUCCUGCAUCCUUAUGGCGUGCCU 27691265 UCUCUUGUUUCCAUUUCCAAAAUCCCCCAACUCAUCCUUUCAGUGACGCC 2770Attorney Docket No.: 62801.85WO011266 AAAGCAUGCUGGCGUCUGAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2771 1267 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2772 1268 UGCCGGACUUUAUUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2773 1269 UGCCGGACUUUAAUUUCUUGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2774 1270 UGCCGGACUUUAAUUUCUAGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2775 1271 UGCCGGACUUUAAUUUCUGGAAGUCAAUAAAACUUGUUUUAGAAGACGAA 2776 1272 UGCCGGACUGUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2777 1273 UGCCGGACUUUAAUUUCUGGAAGUGUAUAAAACUUGUUUUAGAAGACGAG 2778 1274 UGCCCGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUCUAGAAGGCGAG 2779 1275 UGCCGGACUUUUAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2780 1276 ACCCUUAUAUCCUUUUAUCAAAUCCCAAACCUUAUCCUUCCUGUGACGCU 2781 1277 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAUACUUGUUUUAGAAGACGAG 2782 1278 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2783 1279 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGAUUUAGAAGACGAG 2784 1280 UGCCGGAAUUUAAUUCUUGGAAGUGAACAAAACUUGUUUUGGAAGACGAG 2785 1281 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGGUUCAGAAGACGAG 2786 1282 UGCCGGACUUUAGUUCUUGGAAGUGAAUAAAACUUGUUUUACAAGACGAG 2787 1283 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACAAG 2788 1284 UGCCGGACUUUAAGUCUUGGAAGUGAAUAAACCUUGUAUUAGAAGACAAG 2789 1285 UCCGGGACUUUAAUCCUCUGAACUGAAUAAAACUUCUCUUUGAAUCCGAU 2790 1286 UGCCGGACUUUAAUUGUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2791 1287 ACUCUUAUUUCCUUUUUCAUAAUCCCUCAACUCAUCCUUCCUGCGACGCC 2792 1288 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGAGGAG 2793 1289 UUCCCUUAGGACUUAUAUCUUUCAGAUCCCACAUCGUUUCCCAAUUGGAG 2794 1290 UUCUCUAAGUCCUUAUACCUUUCAGUUUCCACACCGUUUCCAAAUUCGAA 2795 1291 UUCCAUUAGGACUGAUAUCUUUCAGCUCCCACAUCGUUUCCCAAUUAGAG 2796 1292 UUUCCUUAGAACUCAUAGUUUUCAGCUCCCGCAUAGUUUCCCUAUUUGAU 2797 1293 UUCCCUUAGAACUUAUAUUUUUCAGAUCCCACAUCGUUUCCCAAUUGGAG 2798 1294 GUCCAUUAGGAGUUCAAUCUUACACAUCCCACGUCGUUUCCCAAUUGGAG 2799 1295 UUCCGUUAGGACUUAAAUCUUUCACAUCCCACGUCGUUUCCCAAUUGGAG 2800 1296 UUCCCUUAGCACUUACCUCCUUCAGAUCCCACAUCGUUUCCCGAUUCUAC 2801 1297 AACUCUCAUAUCUUAUAUCGUACAGAUUCCGCGUCCUUUCCUAAUUGGUA 2802 1298 ACUCUUGAUCCCUUUUGCAAUAUACCACACCUCAUCCUUUCUCCGCUGUC 2803 1299 AUCCCUUAGGACUUAUACCUUUCACAUCCCACCUCGUUUCCCAGUUGGAG 2804 1300 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2805 1301 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAAACGAG 2806 1302 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAGAAGAG 2807 1303 CAAUGGCGUGUAGUCUAGGGCGGUGGAUGAGGCUAGCUCUCGAAUACCAG 2808 1304 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUAUUUUAGAAGCCGAG 2809 1305 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUCUUUUAGAAGACGAG 2810 1306 UGACGGACUUUAAUCUUUGGAAGUGAAUAAAAAUUCUUUUAGAAGACGAG 2811 1307 UGCCGGACGUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2812 1308 UGCCUGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAACCGAG 2813 1309 ACUCUUGAUUCCUUCCUGAUAAUCCCACAUCUCAACCUUCCUGCGACGCC 2814 1310 UGCCGGACGUUAAUGUUUGGAAGUGAAUAAAACUUGUUAUAGAAGACGGG 2815 1311 UGCCGGACUUUAAUUUUCGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2816 1312 UGCCGGACUUUAGCAAUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAA 2817 1313 UGCCGGAGUUUAAUAUUCGAAAGUGAAUCAAACUUGUUUUAGAAGACGAU 28181314 UGCCAUAUUUUAACUUUCGUAUGUGAAUCAAACGUGUGCUAAACCACGAA 2819Attorney Docket No.: 62801.85WO011315 UGCCGGACUUUAAUAUUUUGAAGUGACUAAAACUUGUCUUAGAAGACGAG 2820 1316 UGCCGUACUUUAACUUUCGCAGGUGAAUAAAACUUGUUUUAGAAGACGAG 2821 1317 UGCCGGAGUUUAAUUUUCGGAAGUGAAUAAUACUUGUUUUAGAAGACGAU 2822 1318 UGCCGGAAUUUAAUAUUUGGAAGUCAAUAAAGCUUGUUUCAGAACGCGAC 2823 1319 UGCCGGACUUCAAUAUCUGCAUAUAAAUAAAUCUUGUUUUAGAAGUCGAC 2824 1320 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCGUUCCUGCGAAGCU 2825 1321 UGCCGGACUUUAAUUUACUGCUGUAAAUCAAACUUGUUUUAGAAGACGAA 2826 1322 UUCCCUUAGAACUUAUAUCUUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 2827 1323 UUCCCUUAGAACUUAUAUCUUUCGGGUCCCACAUCGUUUCCCAAUUGGAG 2828 1324 AGUAGUCAUACAUGGAUCGAUAUUCCAGCGUAGUCGCUUUUCAGAUAAUU 2829 1325 UUGCCUUACAACUUAUAUUUUUCAGGUCCCACAUCGUUUCACGAUUAGAG 2830 1326 UUCCCUUAGAACUUAUAUCUUCCAGGUCCCACAUCGUUUCCCAAUUCGAG 2831 1327 UUCCCUUAGAACUUAUAUCAUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 2832 1328 UUCCCUUAGAGCUUAUAUCUUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 2833 1329 UUCCGUUAGAACUUUUAUCUUUCAGGUCCCACAUCGAUUACCAAUUGGAG 2834 1330 UUCCUUUAGAACUAAUAUCUUUCAGGUCCCUCAUCGUUUUCAAAUUGGAG 2835 1331 ACCCUUCUUUCCUCGUUCAAAAUCCCACACAUCAUCCAUCUUGCGACGUU 2836 1332 UUCCCUUAGAACUUAUAUCUUUCAGGUCACACAUCGUUUCCGAAUUGCAU 2837 1333 GAGAAUAAACUAGUAUUCUUCUGGUCCCCACAGACUCAGAGAGAACCCGCCACC 2838 1334 UUCCCUUAGGACUUAUAUCUUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 2839 1335 UUCCCUUAGGACUUAUAUCUUUCACGUCCCACAUCGUUUCCCAAUUGGAG 2840 1336 UUCCCUUAGGACUUAUAUCUUUCUGGUCCCACAUCGUUUCCCAAUUGGAG 2841 1337 UUCCCUUAGGACUUAUAUCUUUCGGGUCCCACAUCGUUUCCCAAUUGGAG 2842 1338 UUCCCUUAGGACUUAUAUCUUUCAGAUCCCACAUCGUUUCCCAAUUGGAG 2843 1339 UUCCCUUAGGACUUAUAUCUUUCAGUUCCCACAUCGUUUCCCAAUUGGAG 2844 1340 UUCCCUUAGAACUUAUAUCUUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 2845 1341 UUCCCUUAGGACUUAUAUCUUUCAGGUCCUACAUCGUUUCCCAAUUGGAG 2846 1342 UUCCCUUAGGACUUAUAUCUUUCAGGUCCCAAAUCGUUUCCCAAUUGGAG 2847 1343 UUCCCUUAGGACUUAUAUCUUUCAAGUCCCACAUCGUUUCCCAAUUGGAG 2848 1344 GCCGUAGCUGCUUCCACGUCCUUGCUUCACCUCACGUAAAGAGAGAAGUA 2849 1345 GCCGUAGCUGCUUCCACGUCCUUGCUUCACCUCAGGUAAAGAGAGAAGUA 2850 1346 GCCGUAGCUGCUUCUACGUCCUUGCUUCACCUCAGGUAAAGAGAGAAGUA 2851 1347 GCCGUAGCUGCUUCAACGUCCUUGCUUCACCUCAGGUAAAGAGAGAAGUA 2852 1348 GCCGUAGCUGCUUCCACGUCCUUGCUUCACCUCAAGUAAAGAGAGAAGUA 2853 1349 GCCGUAGCUGCUUCCACGUCCUUGCUUCACCUCAGUUAAAGAGAGAAGUA 2854 1350 GCCGUAGCUUCUUCCACGUCCUUGCUUCACCUCAGGUAAAGAGAGAAGUA 2855 1351 GCCGUAGCUGCUUCCACGUCCUUGCUUCACUUCAGGUAAAGAGAGAAGUA 2856 1352 GCCGUAGCUGCUUCCACGUCCUUGCUUCACCUUAGGUAAAGAGAGAAGUA 2857 1353 GCCGUAUCUGCUUCCACGUCCUUGCUUCACCUCAGGUAAAGAGAGAAGUA 2858 1354 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCG 2859 1355 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2860 1356 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2861 1357 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUUAUCCUUCCUGCGACGCC 2862 1358 ACUCUUGUUUCCUUUAUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2863 1359 ACUCUUGUUUCCUUUUUCAAAAUCCCACAUCUCAUCCUUCCUGCGACGCC 2864 1360 ACCCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2865 1361 ACUCUUGUUUCCUUUUUCAAUAUCCCACACCUCAUCCUUCCUGCGACGCC 2866 1362 ACUCUUGUUUCCUUUGUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 28671363 ACUCUUGUUUCGUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2868Attorney Docket No.: 62801.85WO011364 AAUGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2869 1365 AAAGCUUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2870 1366 AAAGCAUUCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2871 1367 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2872 1368 AAAGCAUACUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2873 1369 AAAGCGUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2874 1370 AAAGCACGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2875 1371 AAAGCAUCCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2876 1372 AAAGCCUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2877 1373 AAAGCAAGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2878 1374 GGGUCAUAGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2879 1375 GGGUCUUGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2880 1376 GGGUCAUCGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2881 1377 GGGUCGUGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2882 1378 GGGUCAUGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2883 1379 GGGUCAUUGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2884 1380 GGGUCAAGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2885 1381 GGGUCCUGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2886 1382 GGGUCACGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2887 1383 GGGUCAGGGUCCCCCUGUGUUUGUUUCAGAAGCACGAGUUCUCUGUGGAC 2888 1384 CGGCUGUUUACACAUUGAUGUUCCUAAAUAUGCUACGAAUGCUUUCUAAU 2889 1385 CGGCUGUUUACACACUGAUGUUCCUAAAUAUGCUACGAAUGCUUUCUAAU 2890 1386 CGGCUGUUUACACAGUGAUGUUCCUAAAUAUGCUACGAAUGCUUUCUAAU 2891 1387 CGGCUGUUUACACAAUGAUGUUCCUAAAUAUGCUAUGAAUGCUUUCUAAU 2892 1388 CGGCUGUUUACACAAUGAUGUUCCUAUAUAUGCUACGAAUGCUUUCUAAU 2893 1389 CGGCUGUUUACACAAUGAUGUUCCUAAAUAUGCUACGAAUGCUUUCUAAU 2894 1390 CGGCUGUUUACACAAUGAUGUUCCUAAAUAUGCUACGAAUGCUUUCUAAG 2895 1391 CGGCUGUUUACACAAUGAUCUUCCUAAAUAUGCUACGAAUGCUUUCUAAU 2896 1392 CGGCUGUUUACUCAAUGAUGUUCCUAAAUAUGCUACGAAUGCUUUCUAAU 2897 1393 CGGCUGUUUACACAAUGAUGUUCCUAAAUCUGCUACGAAUGCUUUCUAAU 2898 1394 UGCCGGACUUUAAUUAUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2899 1395 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2900 1396 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2901 1397 UGCCGGACUUUAAUAUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2902 1398 UGCCGGACUUUAGUUUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2903 1399 UGCCGGACUUUAAUUUUCGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2904 1400 UGCCGGACUUUAAUUUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2905 1401 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2906 1402 UGCCGGACUUUACUUUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2907 1403 UGCCGGACUUUAAUUGUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2908 1404 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCCCUCGUCAGUACUAG 2909 1405 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCCAUCGUCAGUACAAG 2910 1406 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAUCCCUCGUCAGUACAAG 2911 1407 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCUCUCGUCAGUACAAG 2912 1408 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAUCAGCCCUCGUCAGUACAAG 2913 1409 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCACUCGUCAGUACAAG 2914 1410 CAGCUAUUGUUCAGCUUCUGGAAUUUCUGAGCAGCCCUCGUCAGUACAAG 2915 1411 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCCCUCGUCAGUACAAG 29161412 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCCCUCGUCAAUACAAG 2917Attorney Docket No.: 62801.85WO011413 CAGCUCUUGUUCAGCUUCUGGAAUUUCUGAGCAGCGCUCGUCAGUACAAG 2918 1414 CGCCUCCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAACACG 2919 1415 CGCCUCCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAACUCC 2920 1416 CGCCUCCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAAUACC 2921 1417 CGCCUCCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGUACAACACC 2922 1418 CGCCUCCUUCCCGAUUUAUAUCGCCAUUAUCCUACUCUACGCACAACACC 2923 1419 CGCCUCCUUCCCGUUGUAUAUCGCCAUUAUCCUACUCUACGCACAACACC 2924 1420 CGCCUUCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAACACC 2925 1421 CGCCUCCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAAGACC 2926 1422 CGCCUCCUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAACACC 2927 1423 CGCCUCAUUCCCGAUGUAUAUCGCCAUUAUCCUACUCUACGCACAACACC 2928 1424 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2929 1425 AUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2930 1426 AGUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2931 1427 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2932 1428 GCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2933 1429 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2934 1430 CCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2935 1431 GCUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2936 1432 UCUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2937 1433 AAUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2938 1434 GGUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2939 1435 ACUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2940 1436 CAUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2941 1437 AUUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2942 1438 CGUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2943 1439 CUUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2944 1440 GAUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2945 1441 UGUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2946 1442 GUUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2947 1443 UAUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2948 1444 UUUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2949 1445 AGUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2950 1446 AAAGCAUGCUGGCGUCUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2951 1447 AAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2952 1448 CCUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2953 1449 AGUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2954 1450 GCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2955 1451 UCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2956 1452 AAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2957 1453 AUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2958 1454 ACUCUUGUUUCCUUUUUCAAAAUCCAAUACCUCAUCUUUCCUGCGACGCC 2959 1455 ACUCUUGUUUCCUUUUUCAAGAUCCUAUACCUCAUCCUUCCUGCGACGCC 2960 1456 CAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2961 1457 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2962 1458 CGUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2963 1459 CCUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2964 1460 CUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 29651461 ACUCUUGUUUCCUUUUUCAAAAUCCCGUACCUCAUCCUUCCUGCAACGCC 2966Attorney Docket No.: 62801.85WO011462 AUUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2967 1463 AGUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2968 1464 AAUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2969 1465 UCUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2970 1466 GCUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2971 1467 CCUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2972 1468 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2973 1469 ACUCUUGUUUCCUUUUUCAAAAUCCCACACCUCAUCCUUCCUGCGACGCC 2974 1470 ACUCUUGUUUCCUUUUGCAAAAUCCCAUACCUCAUCCUUCCUGCAACGCC 2975 1471 GGUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2976 1472 ACUCUUGUUUCCUUUUCCAAAAUCGCAUACCUCAUCCUUCCUGCGACGCC 2977 1473 GUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2978 1474 ACUCUUGUUUCCUUUUUCAAAAUCCAAUACCCCAUCCUUCCUGCGACGCC 2979 1475 ACUCUUGCUUCCUUUUUCAAAAUCCAAUACCUCAUCCUUCCUGCGACGCC 2980 1476 UGUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2981 1477 UUUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2982 1478 ACUCUUGUUUCCUUUUUCAAAAUCCUAUACCUCAUCCUUCCUCCGACGCC 2983 1479 UUCCCUUAGGACUUAUAUCUUUCAGAUCCCACAUCGUUUCCCAAUUGGAG 2984 1480 UAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2985 1481 ACUCUUGUUUCCUUUUUCAAAAUCCAAUACCUCAUCCUUCCUGCGUCGCC 2986 1482 GAUCUUGUUUCCUUUUUCAAAAUCCCAUACCUCAUCCUUCCUGCGACGCC 2987 1483 ACUCUUGUUUCCUUUUUCAAAAUCCUCUACCUCAUCCUUCCUGCGACGCC 2988 1484 AAAGCAUGCUGGCGUGUCAAGGAGUUCCCCUGCAUCCUUAUGGCGUGCCU 2989 1485 AAAGCAUGCUGGGGUCUCAAGGAGUUCUCCAGCAUCCUUAUGGCGUGCCU 2990 1486 AAAGCAUGGUGGCGUCUCAAGGACUUCUCCUGCAUCCUUAUGGCGUGCCU 2991 1487 AAAGCAUGCGGGCGUCUCAAGGAGUUCUCCGGCAUCCUUAUGGCGUGCCU 2992 1488 AAAGCAUGCUGGCGUCUCAAGGUGGUCUCCUGCAUCCUUAUGGCGUGCCU 2993 1489 AAAGCAUGGUGGCGUGUCAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2994 1490 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 2995 1491 AAAGCAUGCUGGCGUGUAAAGGAGUUCUCCUGCAUCCUUAUGGCGUGCCU 2996 1492 AAAGCAUGCUGGCGUCUCAAGGAGUUCGCAUGCAUCCUUAUGGCGUGCCU 2997 1493 AAAGCAUGCUGGCGUCUCAAGGAGUUUUCCUGCAUGCUUAUGGCGUGCCU 2998 1494 AAAGCAUGCUGGGGUCUCAAGGAGUUCUCCUGCAUGCUUAUGGCGUGCCU 2999 1495 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUGUUAAAAGACGAG 3000 1496 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUAAAAAGACGAG 3001 1497 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGGUUUAAAAGACGAG 3002 1498 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUAACAAGACGAG 3003 1499 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUCUAAAAGACGAG 3004 1500 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGUUUUACAAGCCGAG 3005 1501 UGCCGGACUUUAAUUUUCGGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 3006 1502 UGCCGGACUUUAAUUUCUGGAAGUGAAUAAAACUUGAUUAAGAAGACGAG 3007 1503 UGCCCGACUUUAAUUUCUUGAAGUGAAUAAAACUUGUUUUAGAAGACGAG 3008 1504 UGGCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGGUUUAGAAGACGAG 3009 1505 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAAGUUGUUUUAAAAGACGAG 3010 1506 UGCCGGACUUUAAUACUUGGAAGUGAAUAAAACUUGUUUUAAAAGACGAG 3011 1507 UGCCGGACUUUAAUUCUUGGAAGUGAAAAAAACUUGUUAUAGAAGACGAG 3012 1508 UGCCGGACUUUAAUUCUUGGAAGUGAAUAAAACUUGGUUUAAAAGACGAG 3013 1509 UGCCGGCCUUUAAUUCUUGGAAGUGAAUAAAACUUGUUUUAGAAGUCGAG 30141510 UGCCGGACUUUAAUCAUUGGAAGUGAAUAAAACUUGUUUUAAAAGACGAG 3015Attorney Docket No.: 62801.85WO011511 UGCCGGACUUUAAUCUUUGGAAGUGAAUAAAACUUGGUUUAAAAGACGAG 3016 1512 UUCCCUUAGAACUUAUAUCUUUCAGGUCCCACAUCGUUUCCCAAUUGGAG 30171513 UGCCGGACUUUAAUUUUCGGAAGUGAAUAAAACUUGUCAUAGAAGACGAG 3018

[0118] In some embodiments, the 5' UTR is isolated. In some embodiments, 5' UTR is engineered. In some embodiments, 5' UTR is isolated and engineered.

[0119] In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5’ UTR set forth in Table 1. In some embodiments, the nucleotide sequence of 5' UTR comprises the nucleotide sequence of a 5' UTR set forth in Table 1.

[0120] In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 85%. 86%, 87%, 88%, 89%, 90%, 91%. 92%, 93%, 94%, 95%, 96%, 97%. 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%. 94%, 95%, 96%, 97%, 98%. 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of 5’ UTR comprises the nucleotide sequence of any one of 5' UTRs-1-1513.

[0121] In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of 5' UTR comprises a nucleotide sequence at least 95%, 96%, 97%. 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of 5' UTR comprises the nucleotide sequenceAttorney Docket No.: 62801.85WO01set forth in any one of SEQ ID NOS: 1506-3018.

[0122] In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 85%. 86%, 87%, 88%, 89%, 90%. 91%. 92%, 93%, 94%, 95%, 96%. 97%. 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5’ UTR consists of a nucleotide sequence at least 90%, 91%. 92%, 93%, 94%. 95%, 96%, 97%. 98%, 99%. or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 95%. 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5’ UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR consists of the nucleotide sequence of a 5' UTR set forth in Table 1.

[0123] In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5’ UTR consists of a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR consists of the nucleotide sequence of any one of 5' UTRs-1-1513.

[0124] In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR consists of a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR consists of the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

[0125] In one aspect, provided herein are nucleic acid molecules (e.g., RNA molecules, DNA molecules) comprising a 5' UTR described herein. In some embodiments, the nucleic acidAttorney Docket No.: 62801.85WO01molecule (e.g., RNA molecules, DNA molecules) is isolated. In some embodiments, the 5' UTR is engineered.

[0126] In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises the nucleotide sequence of a 5' UTR set forth in Table 1.

[0127] In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises the nucleotide sequence of any one of 5' UTRs-1-1513.

[0128] In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNAAttorney Docket No.: 62801.85WO01molecules) comprises a nucleotide sequence at least 90%, 91 %, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

[0129] In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%.90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%.98%, 99%, or 100% identical to the nucleotide sequence of a 5’ UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 90%. 91%. 92%, 93%, 94%, 95%, 96%, 97%. 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of a 5' UTR set forth in Table 1. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of the nucleotide sequence of a 5' UTR set forth in Table 1.

[0130] In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence of any one of 5' UTRs-1-1513. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule (e.g., RNA molecules, DNAAttorney Docket No.: 62801.85WO01molecules) consists of the nucleotide sequence of any one of 5' UTRs- 1-1513.

[0131] In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule {e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule {e.g., RNA molecules. DNA molecules) consists of a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule {e.g., RNA molecules, DNA molecules) consists of a nucleotide sequence at least 95%, 96%, 97%, 98%. 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018. In some embodiments, the nucleotide sequence of the 5' UTR of the nucleic acid molecule {e.g., RNA molecules, DNA molecules) consists of the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.5.3 3' Untranslated Regions

[0132] In one aspect, provided herein are 3' untranslated regions (UTRs) (and nucleic acid molecules comprising the same {e.g., RNA molecules, {e.g., mRNA molecules), DNA molecules). The nucleotide sequence of 3' UTRs-1-1505 (SEQ ID NOS: 1-1505, respectively) is set forth below in Table 2. For the sake of convenience, “U” is utilized in Table 2. It should be understood that “T” would take the place of “U” in the corresponding DNA sequence. Thus, throughout this application it will be understood that where RNA sequences are described, “U” in the RNA sequence will be replaced with “T” in the corresponding DNA sequences. As such, every RNA sequence utilizing “U” does not need to be explicitly recited only replacing each “U” with “T”. The sequences with “U” or “T” are specifically contemplated herein.Table 2. Nucleotide Sequence of 3' Untranslated Regions.3’ UTR SEQ ID Nucleotide Sequence ID NO CUGAUAAUAGGCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCC1 CUCCUCCCCUUCCUGCACCCGUACCCCCUCCAUAAAGUAGGAAACACUACAGUGGUCUUUG 1 AAUAAAGUCUGAGUGGGCGGCAUCUAG UUAAAAGCAUCUCAGCCUACCAUGAGAAUAAGAGAAAGAAAAUGAAGAUCAAUAGCUUAUU CAUCUCUUUUUCUUUUUCGUUGGUGUAAAGCCAACACCCUGUCUAAAAAACAUAAAUUUCU2 UUAAUCAUUUUGCCUCUUUUCUCUGUGCUUCAAUUAAUAAAAAAUGGAAAGAACCUAGAUC 2UAttorney Docket No.: 62801.85WO01CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCC 3 GAG GGGAAAC AGC AGUGAUUAAC C UUUAGC AAUAAAC GAAAGUUUAAC UAAGC UAUAC UAA CCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACC AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 4 CAUGGUUGUACUGCACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACCCUGG UGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCUAACU 5 GUUCUUAC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCC UCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 6 UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCAGCCCCU CCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAUAAAGUCUGAGUGGGCGGC 7 UGAUAAUAGGCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCAGCCCCU CCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAUAAAGUCUGAGUGGGCGGC 8 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 9 GAGCUCGAAUUUCCCCGAUCGUUCAAACAUUUGGCAAUAAAGUUUCUUAAGAUUGAAUCCU GUUGCCGGUCUUGCGAUGAUUAUCAUAUAAUUUCUGUUGAAUUACGUUAAGCAUGUAAUAA UUAACAUGUAAUGCAUGACGUUAUUUAUGAGAUGGGUUUUUAUGAUUAGAGUCCCGCAAUU 10 AUACAUUUAAUACGCGAUAGAAAACAAAAUAUAGCGCGCAAACUAGGAUAAAUUAUCGCGC GCGGUGUCAUCUAUGUUACUAGAUCGGGAAUUC UCGUCGCCGCAGGGUUUGAUGAUCACUAGGACAUGUACGUAUUAAUCACCGUAUUUAUACA GUGCUUAGUGUGUUACUAGUAUCGACUGGUUCUCGAGAUGAAAAUUUGUUGUAAAUUUCAA GGAGUUUCAGGCUGCAAUGGAUGAUUGUGUAAUUAGGAACGGGAAAAAAAGGGGGCUCCUA 11 GGCUCCUAGCAA UCUGCUUGACCGCAGAUCCGCGCACUAUUAGACUUAC 12 ACGCAGCGACGGGAAGCACUUACACUUAC 13 GUUCAAAACUAGGGCUACGGCAAUUCUACCGGCCCGCCGACUCCUGCAUCAUCAUAAAUAU AUAUACUAUACUAUACUACUACGUACCUACCGAUAUGCACCCGAGCAAUGUGAAUGCGUCG AGUACUAUAUAUCUGUUUUCUGCAUCUACAUAUAUAUACCGGAUCAAUCGCCCAAUGUGAA 14 UGUAAUAAGCAAUAUCAUUUUCUACCACUUUUCAUUCCUAACGCUGAGCUUUUUAUGUACU AUAUCUUAUAUGAUGAAUAAUAAUAUGACCGCCUUGUGAUCUA GCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 15 UGAUAAUAGGCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCC UCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 16 GCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGGCCUCCCAACGGGCCCUCCUCCCCU CCUUGCACCGGCCCUUCCUGGUCUUUGAAUAAAGUCUGAGUGGGCAG 17 GCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAACUACU AAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACAUUUA 18 UUUUCAUUGC CUCGAGCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGA GUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUC UGCUAGUUCCAGACACCUCCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCA 19 CACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUA UACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACCCUGGAGCUAGC GGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCUGUC UUUCAGAUCUCAAAGGCUCUUUUCAGAGCCACCA 20 GGACUAGUGUCCACCUGUCCCUCCUGGGCUGCUGGAUUGUCUCGUUUUCCUGCCAAAUAAA CAGGAUCAGCGCUUUACAGAUCUCAAAGGCUCUUUUCAGAGCCACCA 21 GGACUAGUUAUAAGACUGACUAGCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUG CACCGAGAUUAAUCAAAGGCUCUUUUCAGAGCCACCA 22 GGACUAGUUAUAAGACUGACUAGCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUG23CACCGAGAUUAAUAGAUCUCAAAGGCUCUUUUCAGAGCCACCAAttorney Docket No.: 62801.85WO01GGACUAGUUAUAAGACUGACUAGCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUG CACCGAGAGAUCUCAAAGGCUCUUUUCAGAGCCACCA 24 GGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCUGUC UUUCAGAUCU 25 GGACUAGUGUCCACCUGUCCCUCCUGGGCUGCUGGAUUGUCUCGUUUUCCUGCCAAAUAAA CAGGAUCAGCGCUUUACAGAUCU 26 GGACUAGUUAUAAGACUGACUAGCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUG CACCGAGAUUAAU 27 GGACUAGUUAUAAGACUGACUAGCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUG CACCGAGAUUAAUAGAUCU 28 GGACUAGUUAUAAGACUGACUAGCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUG CACCGAGAGAUCU 29 CCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCUGUCUUUC 30 AAUAAGGAAACUGUAUGAAUGUCUGUGGGCAGGAAGUGAAGAGAUCCUUCUGUAAAGGUUU UUGGAAUUAUGUCUGCUGAAUAAUAAACUUUUUUGAAAUAAUAAAUCUGGUAGAAAAAUG 31 ACUGGCUGCAUCUCCCUUUCCUCUGUCCUCCAUCCUUCUCCCAGGAUGGUGAAGGGGGACC UGGUACCCAGUGAUCCCCACCCCAGGAUCCUAAAUCAUGACUUACCUGCUAAUAAAAACUC 32 AUUGGAAAAGUGAGA GGAAGCAUUUUCCUGGCUGAUUAAAAGAAAUUACUCAGCUAUGGUCAUCUGUUCCUGUUAG AAGGCUAUGCAGCAUAUUAUAUACUAUGCGCAUGUUAUGAAAUGCAUAAUAAAAAAUUUUA 33 AAAAAUCU GUCCACCUGUCCCUCCUGGGCUGCUGGAUUGUCUCGUUUUCCUGCCAAAUAAACAGGAUCA GCGCUUUAC 34 GCAUCACAUUUAAAAGCAUCUCAGCCUACCAUGAGAAUAAGAGAAAGAAAAUGAAGAUCAA UAGCUUAUUCAUCUCUUUUUCUUUUUCGUUGGUGUAAAGCCAACACCCUGUCUAAAAAACA UAAAUUUCUUUAAUCAUUUUGCCUCUUUUCUCUGUGCUUCAAUUAAUAAAAAAUGGAAAGA 35 ACCU GCCCGAUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCG 36 CAUCACAUUUAAAAGCAUCUCAGCCUACCAUGAGAAUAAGAGAAAGAAAAUGAAGAUCAAA AGCUUAUUCAUCUGUUUUUCUUUUUCGUUGGUGUAAAGCCAACACCCUGUCUAAAAAACAU AAAUUUCUUUAAUCAUUUUGCCUCUUUUCUCUGUGCUUCAAUUAAUAAAAAAUGGAAAGAA 37 UCU CAUCACAUUUAAAAGCAUCUCAGCCUACCAUGAGAAUAAGAGAAAGAAAAUGAAGAUCAAU AGCUUAUUCAUCUCUUUUUCUUUUUCGUUGGUGUAAAGCCAACACCCUGUCUAAAAAACAU AAAUUUCUUUAAUCAUUUUGCCUCUUUUCUCUGUGCUUCAAUUAAUAAAAAAUGGAAAGAA 38 ecuUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCC UCCCCUUCCUGCACCCGUACCCCCCAAACACCAUUGUCACACUCCAGUGGUCUUUGAAUAA 39 AGUCUGAGUGGGCGGC UAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCC UCCCCUUCCUGCACCCGUACCCCCUAUUUAGUGUGAUAAUGGCGUUGUGGUCUUUGAAUAA 40 AGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCC UCCUCCCCUUCCUGCACCCGUACCCCCCAAACACCAUUGUCACACUCCAGUGGUCUUUGAA 41 UAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCC UCCUCCCCUUCCUGCACCCGUACCCCCCAAACACCAUUGUCACACUCCAGUGGUCUUUGAA 42 UAAAGUCUGAGUGGGCGGC ACACACUCCACCUCCAGCACGCGACUUCUCAGGACGACGAAUCUUCUCAAUGGGGGGGCGG CUGAGCUCCAGCCACCCCGCAGUCACUUUCUUUGUAACAACUUCCGUUGCUGCCAUCGUAA ACUGACACAGUGUUUAUAACGUGUACAUACAUUAACUUAUUACCUCAUUUUGUUAUUUUUC 43 GAAACAAAGCCCUGUGGAAGAAAAUGGAAAACUUGAAGAAGCAUUAAAGUCAUUCUGUUAA GCUGCGUAAAUGGUCUUUGAAUAAAGCCUGAGUAGGAAGUCUAGA GCUGCCUUCUGCGGGGCUUGCCUUCUGGCCAUGCCCUUCUUCUCUCCCUUGCACCUGUACC44UCUUGGUCUUUGAAUAAAGCCUGAGUAGGAAGGCGGCCGCUCGAGCAUGCAUCUAGAAttorney Docket No.: 62801.85WO01UGAUAAUAGUCCAUAAAGUAGGAAACACUACAGCUGGAGCCUCGGUGGCCAUGCUUCUUGC CCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCCGCAUUAUUAC 45 UCACGGUACGAGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCC UCCUCCCCUUCCUGCACCCGUACCCCCCGCAUUAUUACUCACGGUACGAGUGGUCUUUGAA 46 UAAAGUCUGAGUGGGCGGC ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAAGUUUCUU 47 CACAUUCU UUGCCAGCCAUCUGUUGUUUGCCCCUCCCCCGUGCCUUCCUUGACCCUGGAAGGUGCCACU CCCACUGUCCUUUCCUAAUAAAAUGAGGAAAUUGCAUCGCA 48 GCUGCCUUCUGCGGGGCUUGCCUUCUGGCCAUGCCCUUCUUCUCUCCCUUGCACCUGUACC UCUUGGUCUUUGAAUAAAGCCUGAGUAGGAAG 49 UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCCAAACACCAUUGU CACACUCCAUCCCCCCAGCCCCUCCUCCCCUUCCUCCAUAAAGUAGGAAACACUACAUGCA 50 CCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC UGAUAAUAGUCCAUAAAGUAGGAAACACUACAGCUGGAGCCUCGGUGGCCAUGCUUCUUGC CCCUUGGGCCCAAACACCAUUGUCACACUCCAUCCCCCCAGCCCCUCCUCCCCUUCCUGCA 51 CCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC CACAACCGUCCCCGGCCCCUGCCCCGCCCCCAAGCUCGGAUCACAUGAA 52 GGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCUGUC UUUCAGAUCUCAAAGGCUCUUUUCAGAGCCACC 53 CGGGUGGCAUCCCUGUGACCCCUCCCCAGUGCCUCUCCUGGCCCUGGAAGUUGCCACUCCA GUGCCCACCAGCCUUGUCCUAAUAAAAUUAAGUUGCAUCAAGCU 54 UGAGGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCU GUCUUUCAGAUCUCAAAGGCUCUUUUCAGAGCCACC 55 UGAGGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCU GUCUUUCAGAUCU 56 UGAUGAGGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAG CCUGUCUUUCAGAUCUCAAAGGCUCUUUUCAGAGCCACC 57 UGAUGAGGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAG CCUGUCUUUCAGAUCU 58 UGAUGAUGAGGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAA UAGCCUGUCUUUCAGAUCUCAAAGGCUCUUUUCAGAGCCACC 59 UGAUGAUGAGGACUAGUCCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAA UAGCCUGUCUUUCAGAUCU 60 UGAGAGACUCAGCCCAGGAGGACCAGGAUCUUGCCAAAGCAGUAGCAUCCCAUUUGUACCU UUUCUCACUAGAACCUCUAUAAACUUUUCUCACUAGAACCUCUAUAAACUUUUCUCACUAG AACCUCUAUAAACUUUUCUCACUAGAACCUCUAUAAACCGUGUUAGCAGCUCAGGAAGAUG 61 CCGUGAAGCAUUCUUAUUAAACCACCUGCUAUUUCAUUC AUACAGCAGCAAUUGGCAAGCUGCUUACAUAGAACUCGCGGCGAUUGGCAUGCCGCUUUAA AAUUUUUAUUUUAUUUUUCUUUUCUUUUCCGAAUCGGAUUUUGUUUUUAAUAUUUC 62 GCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGA 63 CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC 64 AAUUUCGUGCCAGCCACACC UUGUGUAUGCGUUAAUAAAAAGAAGGAACUCGUA 65 CUCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCC AACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAA ACAUUUAUUUUCAUUGCUGCGUCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGG 66 UUCCUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUC UGGAUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC CUGUAUGAGUUAAUAAAAGACAUGAACUAACAUUUAUUGUUGGGUUUUAUUGCAGUAAAAA GAAUGGUUUUUAAGCACCAAAUUGAUGGUCACACCAUUUCCUUUUAGUAGUGCUACUGCUA 67UCGCUGUGUGAAUGUUGCCUCUGGGGAUUAUGUGACCCAGUGGUUCUGUAUACCUGAttorney Docket No.: 62801.85WO01CUGUAUGAGUUAAUAAAAGACAUGAACUAACAUUUAUUGUUGGGUUUUAUUGCAGUAAAAA GAAUGGUUUUUAAGCACCAAAUUGAUGGUCACACCAUUUCCUUUUAGUAGUGCUACUGCUA UCGCUGUGUGAAUGUUGCCUCUGGGGAUUAUGUGACCCAGUGGUUCUGUAUACCUGCCAGG 68 UGCCAACCACUUGUAAAGGUCUUGAUAUUUUCAAUUCUUAGACUACCUAUACUUUGGCAGA AGUUAUAUUUAAUGUAAGUUGUCUAAAUAUAA CUCGAGCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGA GUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUC UGCUAGUUCCAGACACCUCCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCA CACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUA 69 UACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACCGAGACCUGGUCCAGAGUCGCU AGCCGCGUCGCU UUGUGUAUGCGUUAAUAAAAAGAAGGAACUCGUAAAAACUCAAUGUAUUUCUGAGGAAGCG UGGUGCAUAAUGCCACGCAGCGUCUGCAUAACUUUUAUUAUUUCUUUUAUUAAUCAACAAA 70 UUGUGUAUGCGUUAAUAAAAAGAAGGAACUCGUAUAUGUCUGUUUUUGUAUCUUUAUGCUG UAUUUUAACACUUUGUAUUACUUAGGUUAUU 71 UUGUGUAUGCGUUAAUAAAAAGAAGGAACUCGUAAACUCCAGGACUGUAUUUGUGACUAAU UGUAUAACAGGUU 72 AACCUCAAACCUAGUAAUUUUUUGUUGAUCUCCUAUAAACUCAUGUUUUAUGUAAUAAUUA AUAGUAUGUUUAAUUUUAAAGAUCAUUUAAAAUUAACAUCAGGUAUAUUUUGUAAAUUUAG UUAACAAAUACAUAAAUUUUAAAAUUAUUCUUCCUCUCAAACAUAGGGGUGAUAGCAAACC 73 UGUGAUAAAGGCAAUACAAAAUAUUAGUAAAGUCACCCAAAGAGUCAGGCACUGGGUAUUG UGGAAAUAAAACUAUAUAAACUUAGAA UGCAUUUGUCUGUUGUUGACAUGAGAGAUUCAAGAUCAGAUUCUAGUGUUCAGUAACCCUA UGUGAAUCAGAUGUCUCCUGGAUAACAUUAAAGCCAUGUCUUUGUCAUUAA 74 AGUUCAAGGAAAGUUCUUCUCAGUGUAAUGAACUGUCUAGCAAUAUUAUAGUUAUUCUUGA AAGUAAUGAGUCAAAAUGACACAGCUGAAAAUGAAUAAGCAUCUGAUUUUAUGACUGAGCC UUUUCCUGUCCCAAGAGGUCUUUAACAAUAUUUUCUCUAUCAUCAAUGAGUAUAUUUUAUU 75 UUUAUUAUAAAAAUGAUAUUGUGGUGGACUGCUAAAAAUAUCACAAAUGGCAAUGUAAAAA UCAAGACAUUUUCUCAAGAACUGUGUACCACUA GAUCCAAAGUGGCAGGAGGUCUGUGUUGUCAUGGUGAACUGGAGUUUCUCUUGUGAGAGUU CCCUCAUCUGAAAUCAUGUAUCUGUCUCACAAAUACAAGCAUAAGUAGAAGAUUUGUUGAA 76 GAC AUAGAAC C C UUAUAAAG AUACCCAUUUCAUGAUGAAUACUGACUGCAGGGAGUUCCUGAACAGAUUUUUCACUCCCAC GAGUGCCAAGACGGUGCAAUGGGUAGUCCCCUAGAUGUGAAAAUGAAGAGAGAGGGUUUUA CCAUCCUGAGAAGAAAUAAUGAUGGAAACAUGUUUAAUGUUUGUGCAGUGUAAAUGACUUU 77 GACUCAGUCACAUUGAAGUAAAAAUAUUAAAAUCUGUUGAAAUAACUCUUAGGAAAUUAUC AACUAAUUUUUUCAGAUCAGUAUCUUCUAGAU GAGGAGAAGCUUCCACUCUGAUCUAGUCUGGCAAAAUUGAGGAAAAUAUUCUACCCUG 78 GCCCUGGAUCAAGCUGCCCAUCUACACCCUGGCACAGACGCUGGGAGCCUUCUUGGGUGCU GGAAUAGUUUUUGGGCUGUAUUAUG 79 CUGAAGAUAAAAUUACAG 80 AUGCAUCCACCCCU 81 GGUGAUGCUGAACCGAAUGCUUGAACUAGCAGGAGUGGCUGGGAUUGCAUUGGAGUGGUUC CGUUCAUUCCUUCCGG 82 GGAGUAGGAGGAGGGGAAAAGGAGCUGUUGGUCUCGCUGUCUCUGGAUUGACAGAGGUGGA AGAAAAUCCACAU 83 GUUUCCUGGCAUUUCUAGAGAAACAAGGUAAAAUAGAUGAAGAUAAUCUGACAUGCCUGGA GGACCUCUGCAAAACAGUUGUACCUAAACUUUUGAGAAACAUAGAGAAAUACAAAAGAGAG 84 AAAG UGGGAUAUCGGAAGAGAGGGCCGAAGCCCAAACCGCUAGUGGUGCAG 85 AUUACACACACACACACACACACACACAC 86 AGGUCACCUAUAAACUUUGUUUCAUUUAACUAUUUAUUAACUUUAUAAGUUAAAUAUACUU GGAAAUAAGCAGUUCUCCGAACUGUAGUAUUUCCUUCUCACUACCUUGUACCUUUAUACUU 87AGAUUGGAAUUCUUAAUAAAUAAAAUUAUAUGAAAUUUUCAACUUAAttorney Docket No.: 62801.85WO01CAGGAUUGGACCUUUCAGAUUUCCCAGCAUUAGCAGACCGAAACAGGAGGGAAGGAAGUGG UAACCCAACUCCAUUAAUAAACCCCUUGGCUGGAAGAGCUCCUUAUG 88 ACAGUCUCUGAGAAGUACUUUACCUGAAAGACAGUAUGAGAAAAAUAUUCAAGUAACACUU UAAAACCAGUUACCCAAAAUCUGAUUAGAAGUAUAAGGUGCUCUGAAGUGUCCUAAAUAUU 89 AAUAUCCUGUAAUAAAGCUCUUUAAAAUGAAA GACCAAGAAGCCUGGGGGGCCUGAGAGACUUGAACAAGUGUCAAUAAACGCUGGCCUCUG 90 ACCUCCCCUGUGAGCUAGACUGGACAGCCAAUGACGGGUAAGAGAGUGACAUUUCUCACUA ACCUAAGACAGGAGGGCCGUCAAAGCUACUGCCUAAUCCAAUGACGGGUAAUAGUGACAAG 91 AAAUGUAUCACUCCAACCUAAGACAGGCGCAGCCUCCGAGGGAUGUGU UAUUCCAGAGCUGCUAUUAGAAGCUGCUUCCUGUGAAGAUCAAAUCUUCCUGAGUAAUUAA AUGGACCAACAAUGAG 92 CAAAGCUAUUCUUGAUGCUUUGGUAACAAACAUCCUUUUUAUUCAGAAACAGAAUAUAAUC UUAGCAGUCAAUUAAUGUUAAAUUGAAGAUUUAGAAAAAACUAUAUAUAACACUUAGGAAA GUAUAAAGUUUGAUCAAUAUAGAUAUUCUGCUUUUAUAAUUUAUACCAUGUAGCAUGCAUA 93 UAUUUAACGUAAAUAAGUAAUUUAUAGUAUGUCCUAUUGAGAACCACGGUUACCUAUAUUA UGUAUUAAUAUUGAGUUGAGCAAG CCCUGUCCAGUGUCUGCUUGCCAUCCUGCCAGAACAGGCCCUCAAGCCCAAGAGCCAUCCC AGGCCUGUUCAGGCCUCAGCUAAGCCUCUCUUCAUCUGGAAGAAGAGGCAAGGGGGCAGGA GACCAGGCUCUAGCUCUGGGCCCUCCUUCAGCCCCCAUCAUGGGAAUAAAUUAAUUUUCUC 94 AAUGUA GCGAGGGCUGUGCCGGUGCAGGUCUGGUGGGCGGGGCCAGGGAAAGGGCAGGGCCAAGACC GGGCUUGGGAGAGGGGCGCAGCUAAGACUGGGGGCAGGAUGGCGGAAAGGAAGGGGCGUGG UGGCUAGAGGGAAGAGAAGAAACAGAAGCGGCUCAGUUCACCUUGAUAAGGUGCUUCCGAG 95 CUGGGAUGAGAGGAAGGAAACCCUUACAUUAUGCUAUGAAGAGUAGUAAUAAUAGCAGCUC UUAUUUCCUGA AUCCCAUAGUGGUGUUUCAUGGAUAUGAGGCAGUGAAGGAAGCCCUGAUUGAUAAUGGAGA GGAGUUUUCUGGAAGAGGCAAUUCCCCAAUAUCUCAAAGAAUUACUAAAGGACUUG 96 AGCCCUGGCUGG 97 CCUGCGCGCCCGCCUCGGCCCGCACGCCAAGCACGUGGUGGGCUAUGGCCACCUUG 98 GGAGCCAUCACUGCUUGGAAGAGAUUCUUGGCAG 99 AUUAACUCAGGCAGAAGAGCACAGAUGUGUGGGAUUGGGGGAGGAGUGGGGACAAGAUUUU UUAUCUC CAAGUGAAUUUUC UAAAAAUGUAUUUUAUACC GGC UUAUUC CUAGUAUUGAAUA 100 AACUAGCGGGCUCACUCAG AAGAAAC C C UGC GGAUAAGAAG 101 UGUGGGUCCUGUGACCGCGGCAGCUCCUCAGCGGAGCCGCAGACUGUCCUGCCCUGCAGCA UGUGCCUAAAGGCUCAAGGGGAUAUUCCUCUGGGGUGGCCACUCCCACCACCCUGACCCUG UCUUUCUCUCUGGCCUGCUGCUCUCUCAACAUCACAUACAGCUUCAGCUGCCUGGAGGCCA 102 GAAGGAAAGGGCAGUGCAGGGGAGGCCUGAGCCCGACUUAGCC GGCCCGCAAAGAGGCGGUGCAGACUGCGGCUAAGGAACUCCUCAAGUUCGUGAACCGGAGU CCCUCUCCUUUCCAUG 103 ACAUAGACGAGUGCACUGCAGGGACGCACAACUGUAGAGCAGACCAAGUGUGCAUCAAUUU ACGGGGAUCCUUUGCAUGUCAGUGCCCUCCUGGAUAUCAGAAGCGAGGGGAGCAGUGCGUA 104 G CUCAAAUUAUUGAAGCCUGUGAUGUGUGUCUGAAGGAGGAUGAUAAAG 105 GGUGCAGAAACUGCAGAUGGAAGCUCCCCACAUCAUCGUGGGUACCCCUGGCCGUGUGUUU GAUAUGCUUAACCGGAGAUACCUGU 106 ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 107 AACUGUUCUUAC UUUUUAUUUAAAAUGAAUGUUAUCGUGUGUUACAUUUGGACCUAUUUUAAUAAAGUGGCCU GUCUCAAUU 108 UUUACAUAAAUUUAUAAUGAAAAUAAACAUGUAUAAAAUUUAAAAAAACAGACUCCCAUUU109CUUAAAAACGGAUAAGUUUGAAAGGAAACUGCUAUUGAACUUAAGCAUCUCUAGCAGAGCAAttorney Docket No.: 62801.85WO01AUUUGAUCAGUAUAUAAAACCCUAGGAUGUGCUAGGUCUAAGAUGGAUUAAACAAGUAUAA AAUAAAAUACAUUUAUAAAAUAAAAAGGAAAACAGACUUAAA CCAUGAAGGGUCCUA 110 CAUCUAAAUGUAAUGUAGUAUCCUGGAUGGACUCCUGCAACAGAAAAAGAACUUUAAGUAA AAAUUAAGGGAAUAUUAAUAAAGUAUGCAUUUUGGUUAAUAAUGUAUCAAUAUUGGUUUAU UAGUUGUGACAAAUGUACCAGAGGAAUGUAAAAUGUCAACAAUAAAGGAAAUUGGAUGUGG 111 GGUA AAACAACACCUAUAGCCCUGUAUUAAAAUAUACUCCACAUCAACUCUUAUUUGGUAUAGAU UCAAAUACUCCAUUUGCAAAUCAAGAUACACUUGACUUGACCAGAGAAGAAGAACUUUCUC UUUUACAGGAAAUUCGUACUUCUUUAUACCAUCCAUCCACCCCUCCAGCCUCCUCUCGUUC CUGGUCUCCUGUUGUUGGCCAAUUGGUCCAGGAGAGGGUGGCUAGGCCUGCUUCUUUGAGA CCUCGUUGGCAUAAACCGUCUACUGUACUUAAGGUGUUGAAUCCAAGGACUGUUGUUAUUU UGGACCAUCUUGGCAACAACAGAACUGUAAGUAUAGAUAAUUUAAAACCUACUUCUCAUCA 112 GAAUGGCACCACCAAUGACACUGCAACAAUGGAUCAUUUGGAAAAAAAUGAAUAAAGCGCA UGAGGCACUUCAAAAUACAACAACUGUGACUGAACAGCAGAAGGAACAAAUUAUACUGGAC AUUCAAAAUGAAGAAGUACAACCAACUAGGAGAGAUAAAUUUAGAUAUCUGCUUUAUACUU GUUGUGC AGCAUCCCACAGAAUGAUCCUACUGAAUAACUCCCAUAAGCUGCUGGCCCUAUACAAAUCC UUGGCCAGGAGCAUCCCUGAGUCCCUGAAG 113 CUGGGAUUACAGGCUUGAAUCACCUCACCUGGCUUACUUACAUAUCUCUAAAUAACAUGCC UGUAUUGCUGUUACUUGUUUAAAAAAAUAAA 114 CCAAGAUGGCAGGCUAAUUCUCACACCAGGGCACAGUCUAAUGGGUCCAGCUGACUUCCUG ACUUGAUCAACUUGCCCAGUGUUUAAUGAUGUUUUUCAAGAAGCCGAGCAGGAAA 115 AUCAGGAGGCAUCACUGAGGCCAGGAGCUCUGCCCAUGACCUGUAUCCCACGUACUCCAAC UUCCAUUCCUCGCCCUGCCCCCGGAGCCGAGUCCUGUAUCAGCCCUUUAUCCUCACACGCU 116 UUUCUACAAUGGCAUUCAAUAAAGUGCACGUGUUUCUGGU AGGAACUCUAACCCCGGUGUACCUGUAUAAACUGAACUGUGAAACUGUUUCGGUUAUCUCU GUCUUUUGAGGAUGGCUUUGUCCUGUUGCUGGUUAACAUUCACCUUCCUCUUUUGAGGAGU AUUUUUCCAUUAUGUAUUCAUAAUAAUGUUAAUUUCAAUAAAUGACAUUCAUGCAGCAAUU 117 AUAUUGGUGUAUGAAAUUCUUACAGUGAAUAUUGUGCUGUUAGUGCUGCUUGAAACAUUUC AAUAAAAUAUUGACCAGGA UUCUGAUGGAAGGAGCUGUGCCCACCCUGUACACUUGGCUUCCCCCUGCAACUGCAGGGCC GCUUCUGGGGCCUGGACCACCAUGGGGAGGAAGAGUCCCACUCAUUACAAAUAAAGAAAGG 118 UGGUGUGAGCCUGGGAA AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 119 AAAAAAAA CUGCACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACCCUGGUGCCGCGCUU CCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC 120 ccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc CCCCCCCUCUCCCUCCCCCCCCCCUAACGUUACUGGCCGAAGCCGCUUGGAAUAAGGCCGG 121 UGUGCGUU GGUGUUGACGAAAGUUAACGCUGUGUAUGAUACGUCUUCACAGUACGUGCCGGAAUACAAU CCAGGCCAACUCAGUACCCGAGCGUUGAAUGCGGGUGAGGCGGAUCUGGCUAUGGGAGCGG 122 ACGCCGAG CUGGGGUGAAACCGAGGAGGAUUCGGUACAAUAAGACCUCACAUGACUACCACCUGGAGGA GUUUGAGGCAAGUCUCAACAUGACCCCUCAGACCAGUAUCGCCUCGGGUCAUGAGACAGAC 123 CCCAUAAA AGUGUGAAACAUGUGUGUACAACAUGAUGGGAAAAAGAGAGAAGAAGCUAGGGGAAUUCGG CAAGGCAAAAGGCAGCAGAGCCAUAUGGUACAUGUGGCUUGGAGCACGCUUCUUAGAGUUU 124 GAAGCCCU AUGACUCAGGAGGAAAUUAGAAAAAGGUGGGAAAGGGGAUAUUGUGACCCUUUCAUUGACU CAGGAAGUGACUCAGAUGGACCCCUUUCAAAACCACAGACAGUAAAAGUGUGGUAACACUU 125UAAGCAAUAttorney Docket No.: 62801.85WO01UAAUCAUACCAAUCAACUAUUGAUAUAGGGCUGAGCAGUAUCCCACAUCCUUCCCAACUGC AUCACCAGCAUCACUCCGAUCCAUAGAACCAUACUACACUAUGCACCAUCUAACAUACAGC 126 CAAUCACU GGUUAUGCUAAGUCAAACUUUGUCAAGGAUGAUUACUGUGAUGGUUCAUUGGGCUGCAAGA UGUGUCUUUUUGGUUACCAAGAGUUAAGUCAAUUUAGCCAUUUGGAUGUUGUGUGGAAGCA 127 UAUAACAG AAUUUGUGAUUUUUAUUCUAAGUUAGGUGUAGGUUUUACAAGUCAUUUUUGUAAUGGUAGU UUUAUAUGUGAAUUGUGUCAUUCUGGUUUUGAUAUGUUGGAUACAUAUGCAGCUAUAGAUU 128 UUGUUCAG CAUUGUUAAUGAUGAUACUAGUGAAACCAAAUAUGUUAAGAGUUUGUCUAUUGUUGAUGUG UAUGAUAUGUGGCUUACAGGUUGUAAGUAUGUUGUUAGAACUGCUAAUGCUUUGAGCAGAG 129 CAGUUAAC CCGGACCCCGCCUGUGCGGGCGAGAGCGCGCUCGCGCAGAACAUCGACGUCCAGACGCUAG ACCUGGGCGACUGCGGAGACCCCAGAGGCCGCCGACUGCGCGUGGCGCUGGUGAACAGCGG 130 CCACGCGG GCACGAGGGUGAGCACGUCGUUGAGGACGUCCUCGCCCGCGGCCCGGGGGCCCCCCGGGGU GGCAAAGCGCCCCCCGCCGGGCGGCUCCAGGCCCGCCAGCACCGCCUCCGCGUCCGACGCG 131 CCCAGGGC UACCGGCGGCCCCGGGCGACGUUCCCCGAGACACCAGCACCCGCGUGAACCCCGACGACGU GGCCCACCGCGACGACGUCAACCGCGCCGCCGCCGCGUUUUUGGCACGCGGCCACAACCUC 132 UUCCUGUG GCUUGGGAACACCGGGCAGGUCCGUGAGAACUUUCUUCUACUCGAGGCCUUUUUGGCGUGG UGGCAUUAAUGUCCAGUGGGGUAAAUGCACCUUGACUGUAAUCACUGGCAAAGGGCAUGCU 133 UGGGCAUG AUUAAUGUCCAGUGGGGUAAAUGCACCUUGACUGUAAUCACUGGCAAAGGGCAUGCUUGGG CAUGCUGUACCUGAUGAGUCACACCCCACGGCCAUGCUAUCUUGUAACGGCAUAGGGGGAG 134 GGGGGAAU CGUCAGUUCCCCGUGACGUGGGCCCUGGCCAGCCUGACUGACUUCCUGAAAUCUUUGUAAA UGAAUAAACAGUGGGUGUUGCGUGAUGAGUAAAGUGUAACAUUUAAUGUGGGACUGGGAGG 135 CCGGGGCG ACCUCUUCACGUUACUACGUUCAUAUUCCAAUUCACGUUCGCAUGGGUUACCUUCGCAGUU UUUACGAGCGAUUUCACGUUCCAGAUUACGUUUAGCCUUCAUGUGUCUCUCACUCUCUCUA 136 UCGAGUUU UAAAAAAUAGUUUAACUCUUUUUAGAACCAGUUUGGUACUGGAAUUUCAGUUCAUUCGUUG AGAAUAUUGAUGAUUUUUUUUAAGAUGAUAUUUACUUUUUAUAUGCUUGCAUUACAGAAUA 137 AUAUUCAC GGCGAGUCAGUACAUGCCCGGCCUCGCCUCCGGGCGCACAACUUGGGCCCGCCUCCGGGCA GAUAGCAACCUCGGGAAGCCCUCAGGGGCUCUCCUACACAUUCCUCGGCGCACACUCCUCG 138 GCGCUACG GCGCGCUAGUGGCAAGGGCCUGCGGGCGGCACACACUUGCACGCGCACGCGCCCUAAGGGC CCGCUGGCGGCGCACGCGAGCACGCCUGCACGCGCACUUGCCUGGCGUCCUUCUUUGCGUG 139 CGCCUCGC CUAUUCUAGACCAAAAAUUCGGUUUCAUGUGUUCGAAACGGUAUUCUGCAACAAGUCGAGG AUCGUGUUCUACAUAUUUGGCGGCGUUAUCCAGUAUCUGCCUAUUGAUCUUCAUUUCGUUU 140 UCGAUUCU AAAGUGAGCAAAAAUUAUAAGGUUGUAUUCUAAUCCCAUAUUUGUUAUUUUUUUCUGUAAU AGUUAGAAAAAUACAUUCGAUGGUCUAUCUACCAGAUUAUUAUGUGUUAUAAGGUACUUUU 141 UCUCAUAA GGUCGCUGACGUCAAACCAUCUCGUGCUCGCUGAGUCACAUCCGGUUGUUGACAAGCGAUG GAGGACCGCACCCAAAGUGCGCCCUCUAGUCAUCGCGCCUGACCCCUUUUAUAAACUGCUC 142 GAAGAAAA CACCGCGUUAUCCAUUCCUCGUAGGCUGGUCCUGGGGAACGGGUCGGCGGCCGGUCGGCUU CUGUUUUAUUAUUUUUUUUUUAUUUUUUAUCUUCUCCUUUCCUUAAUCUCGGAUUAUCAUU 143 UCCCUCUC CCCUGAAGUCACGCCUUGGCCCUGACAUCCCCACAUGCCCGCAGAGAUCCUCUUUGAGUGU144CUGUCUUUGUCCAGGUUUCAGACAUUUCUAGGUUGGGGAAGAUGCUAUUGGGAAACCUCUUAttorney Docket No.: 62801.85WO01CUCCGUGACACAGAAUGUUCUGGGUGGGAGCCGCCCUUCUUCAUCUUAGAGAACCAAGUGC CUCCUGUCUGAAAGGUGAGGGUGGCCUGACCUGGGCCUCUCCCUGCCCCUCCAUAGGUGGG UUUGUAGGGUCUUGUGUUGCUUCUGGUCUCUCCAGGCUUGGCUG CCUCUGCUUCCUGGUGCAGAGCUCAGAUUUCAAG 145 AGGCCCUCUUGCGCAGCUGCCUCUCGGCCCCUCCGCCUUCUCCCCUCCUGCUGUCCAUGCU UGGCCCCCUCGUCCCCAUCCACC 146 AACCCUGCAAGUAGACUUACGUGAAUGAUUUUUGCUGUG 147 ACAAGCGUGCACUUACUCCAUUUCAUCUUUCUGUUUCUUGUUGGCUCCUCUACCACCCGGU UGAUAAUUCAGGUUUCUGUGACCAGUAGCUUUGGAAUGGCUUAUGCUUGUUUUCAAUAACU 148 GGUUUGUUUUGAAAUAAAUAAACAAGGUUUAUAAGAAACA GACCCAGAAAGGUUCUUUUGCUUGAGGCCACAGAGCUAGAAAGUGGUAAGAACCAGCUUCA GAACCAGGCAGUGUUGCUCCUGAGCCAUCUUCUUAACCACCACACCGUGGGGCCACCAUAG 149 AGGAUCUGGAGCUCAGCCUGUCGGCUGCAGGGUGCCAGAGGUGGACUCGUUUAGG UUGCAGAUCCCUCUUUUCCAGUUCUCCUUCCUCUAGGAGCCAUGUUAUCCUCUGUCCCCCA UAGAGUCAAGCCUAGUGCUUGAAGGUCCUGACGACACCCACAACAUACAUGAGAGUAAUGG GAUUGAGCAUUUAUGGCAGCAACAGAGGAGCCACAAAAUGUUCUUUGUUCUUUGGCUCCAA 150 AAAGACUGUCAGCUUUCAGUCUCUUUUGAUGGACUGUUUUAUCAGAGUUGACUUUAAAUAC AGCUUGUCUCAUGA CCUCCAGCUCGGAGGACUUGUGUUCAGGGGUCCUGGGCCCCGGGCGAGGUCCCGCCCUCCC GUGGUCACUGGCUCCGCCCCCAGCACCAGGCGCCCAGUGGAGCCGUUUGGGAGAAUUGCCU GCGCCACGCAGCGGGGCCGGACAGGCCGCACAGACCUACUGUGGCGGGAGGGAGGGGCGGC 151 UGCUGCCUGGUGACGGCACCCGGAGGCCCACCAGGACGCGCCACCGGUGAAUGUGCCUCUG GUGGCUGCUGAGAAAAAUACACUGUGCAGCUCA ACUGGAGAAUGUGGCGCGAUGUGAAGAGACGAAAAAUGGCCUAUGAAUACGCAGAUGAGAG GCUACGUAUUAAUUCACUCAGGAAGAAUACCAUUUUGCCAAAAAUUCUUCAG 152 UGCUGGGACAGCCCCGCUCCCAGAUGUAAAGAACGCGACUUCCACAAACCUGGAUUUUUUA UGUACAACCCUGACCGUGACCGUUUGCUAUAUUCCUUUUUCUAUGAAAUAAUGUGAAUGAU 153 AAUAAAACAGCUUUGACUUGA UUCUAUAAAGGCCACCUCGUCAAUAUCUUCAGCUUUGUGGCACUGUGGGUUCUGUCUAGAG CUGUGCCAUUGUGGCACAAAGCUGCUGCAGACAGUAUGUCCAUGCGUGGGUGUG 154 ACAGCCUUUUACUCAGUGUAAAAAUACUAGCAAUACUUCAUAUUAAGCAUAAGCUGAAGAA GAG 155 AUUGUCAUGUGAUUGCCGCCCCAUCAAUGGUUGCUAUGUUUGAAAAUUUUGUAAGCGUAAC UCAGGAAGAAGAUGUACCUCAG 156 CCAGUUGCUAAGUGGGGCUCAAGAAGCACCGCCUUCCCCACCCCCUGCCUGCCAUUCUGAC CUCUUCUCAGAGCACCUAAUUAAAGGGGCUGAAAGUCUGA 157 UUUUUCUCUUUUUCCAAUGGGCGUUCUAACAAAUGUUUAUUCUUAGAUUGGGGAGAGAAGC UAAGGCCAAUAGUUAUUUUACUGUCUCUCAUAUAAGAACAGUCCCACUCUAAGGGUAUUGG 158 AAGUCUUAAUGAAUGACGUAAAGCCAAUAGCAAAUUUC CCUGUUCCAGGCGCCCUCCUCAGGCCAACCACAGCGUCUUGGGUGGGCAGGACAGGCUCUG GAGGGAAAAGCCAGAGAGACCAAGAUGGAGGCUGUGGAGCAGCAUUUCCCGUUGCCUCCAU AGCAAGAAGAGUUUUUGUUUGUUUGUCUGUUUUUUUAACCUCAUUUUUCUAUAUAUUUAUU 159 UCACGACAGAGUUGAAUGUAUGGCCUUCAACAUGAUGCACAUGCUUUUGUGUGAAUGCAGC CAAUGCAUUUUCUUACAGUUUACAGAAUGUGAAGA AAUGGAUAUCAUGGACUACUGCAAAAAAGAAUGGAGAGGAAAUACACAGAAAGCAACGUGU AUGAAAAUG 160 AGGGGCCCUGGAACAACCUGGAGCGUCUGGCAGAGAACACCGGGGAGUUCCAGGAGGUGGU GCGGGCCUUCUACGACACCCUGGACGCUGCCCGCAGCAGCAUCCGCGUCGUUCGU 161 UACACAUGCAAGCAUCCCCGUUCCAGUGAGUUCACCCUCUAAAUCACCACGAUCAAAAGGG ACAAGCAUCAAGCACGCAGCAAUGCAGCUCAAAAACGCUUAGCCUAGCCACACCCCCACGG GAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCA 162 GGGUUGGUCAAUUUCGUGCCAGCCACC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC 163UGAUCCAUUGCCGGUGUGACCUGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUAAttorney Docket No.: 62801.85WO01CUGCCCGGGCCCAUGAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGC ACAGCCCCGCCUUGCCGCUGCUGAUCCAUUGCCGGUGUGACC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC UGAUCCAUUGCCGGUGUGACCUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGU 164 UGCUUCCUGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCU UUUGCUCCUGGACCCUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC UGAUCCAUUGCCGGUGUGACCGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCC 165 UGCCAUUAUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCA UCCCUGUGGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC UGAUCCAUUGCCGGUGUGACCCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCG 166 UCCUGGGUACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGC CCCACUCACCACCUCUGCUAGUUCCAGACACCUCC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC UGAUCCAUUGCCGGUGUGACCCUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCC GAUCCAGUGGGCAGGCCAAGGCCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGG 167 UCCCUGUCCCCGCACCCCCGCUUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCU GCUCUCCCACCUCUACCUCCACCCCCAC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC UGAUCCAUUGCCGGUGUGACCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUU 168 CCUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUG GAUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC UGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAUGAGACUG ACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUGCCGCUGC UGAUCCAUUGCCGGUGUGACCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCC 169 ACACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCU AUACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC CUCUCUGCCCUUCCACUCUCUGACCCCUGCCCGUCCUCACCAAGACUGACUGCCUGCUGCU 170 UUGCUACUGCCCGGGCCCAUGAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGC ACUGGCACAGCCCCGCCUUGCCGCUGCUGAUCCAUUGCCGGUGUGACC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC CUCUCUGCCCUUCCACUCUCUGACCCCUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUA 171 AGAAGUUGCUUCCUGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCA CCUCCUUUUGCUCCUGGACCCUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC CUCUCUGCCCUUCCACUCUCUGACCCCGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUA 172 CCUCCCUGCCAUUAUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGA UCUCCAUCCCUGUGGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC CUCUCUGCCCUUCCACUCUCUGACCCCCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCU 173 UUCCCGUCCUGGGUACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCC ACCUGCCCCACUCACCACCUCUGCUAGUUCCAGACACCUCC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC 174CUCUCUGCCCUUCCACUCUCUGACCCCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAttorney Docket No.: 62801.85WO01AAGGUUCCUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAG CAUCUGGAUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC CUCUCUGCCCUUCCACUCUCUGACCCCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGC 175 CUAGCCACACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAAC UAAGCUAUACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACC UUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGA CCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGC CUCUCUGCCCUUCCACUCUCUGACCCCCUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCU CAUUCUUCCACAAGAGAGACCUUUCUCCGGACCUGGUUGCUACUGGUUCAGCAACUCUGCA 176 GAAAAUGUCCUCCCCUGUGGCUGCCUCAGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGA UGGCAGCCCCUCAUCUUCCAAGUUUUGUGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAU GCAUCUGUACUCCUCC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCUGCCCGUCCUCACCAAGACUGACUGCCU 177 GCUGCUUUGCUACUGCCCGGGCCCAUGAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCC CACUGCACUGGCACAGCCCCGCCUUGCCGCUGCUGAUCCAUUGCCGGUGUGACC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCUUCCAGCCAGACACCCGCCCCCCGGCCC 178 UGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCG CUGCCACCUCCUUUUGCUCCUGGACCCUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCGCCUUGGCUCCUCCAGGAAGGCUCAGGA GCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUU 179 CCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUC CCCCC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCCUGGUACUGCAUGCACGCAAUGCUAGCU 180 GCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCC ACCUCCACCUGCCCCACUCACCACCUCUGCUAGUUCCAGACACCUCC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCCUGACAGCGUGGGCAACGCCUGCCGCCU GCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGGCCUGCUGGGCCCCCGCGGACCCAGGUGC 181 UCUGGGUCACGGUCCCUGUCCCCGCACCCCCGCUUCUGUCUGCCCCAUUGUGGCUCCUCAG GCUCUCUCCCCUGCUCUCCCACCUCUACCUCCACCCCCAC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCGAGAGCUCGCUUUCUUGCUGUCCAAUUU 182 CUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGC CUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCCAAGCACGCAGCAAUGCAGCUCAAAACG 183 C U U AGC C UAGC CACACCCCCAC GGGAAAC AGC AGUGAUUAAC C UUUAGC AAUAAAC GAAAG UUUAACUAAGCUAUACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACC GCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCG CCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUG GUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCCUUUGCAGGAUGAAACACUUCCCCGCUU 184 GGCUCUCAUUCUUCCACAAGAGAGACCUUUCUCCGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUGUCCUCCCCUGUGGCUGCCUCAGCUCAUGCCUUUGGCCUGAAGUCCCAGAttorney Docket No.: 62801.85WO01CAUUGAUGGCAGCCCCUCAUCUUCCAAGUUUUGUGCUCCCCUUUACCUAACGCUUCCUGCC UCCCAUGCAUCUGUACUCCUCC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCUGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCG 185 GGCCCAUGAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCC CGCCUUGCCGCUGCUGAUCCAUUGCCGGUGUGACC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCC 186 UGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUC CUGGACCCUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUU 187 AUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGU GGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGG 188 UACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUC ACCACCUCUGCUAGUUCCAGACACCUCC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGU 189 UCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUG CCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UUCCAGACACCUCCCUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCUCAUUCUUCCACAA GAGAGACCUUUCUCCGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUGUCCUCC 190 CCUGUGGCUGCCUCAGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGAUGGCAGCCCCUCA UCUUCCAAGUUUUGUGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAUGCAUCUGUACUCC UCC CUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGG CCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCACCCCCGC UUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCUACCUCCA CCCCCACUGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUACUGCCCGGGCCCAU 191 GAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCACAGCCCCGCCUUG CCGCUGCUGAUCCAUUGCCGGUGUGACC CUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGG CCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCACCCCCGC UUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCUACCUCCA CCCCCACUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCC 192 AGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACC CUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC CUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGG CCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCACCCCCGC UUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCUACCUCCA CCCCCACGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUG 193 CUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUC ACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCC CUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGG CCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCACCCCCGC UUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCUACCUCCA 194CCCCCACCUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGAttorney Docket No.: 62801.85WO01GCCAAGGCCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCA CCCCCGCUUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCU ACCUCCACCCCCAC CUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGG CCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCACCCCCGC UUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCUACCUCCA CCCCCACGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAA 195 GUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUA AAAAACAUUUAUUUUCAUUGCUGCGUC CUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCGAUCCAGUGGGCAGGCCAAGG CCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGUCCCUGUCCCCGCACCCCCGC UUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUGCUCUCCCACCUCUACCUCCA CCCCCACCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGA 196 AACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGG GUUGGUCAAUUUCGUGCCAGCCACACC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCUGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUAC 197 UGCCCGGGCCCAUGAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCA CAGCCCCGCCUUGCCGCUGCUGAUCCAUUGCCGGUGUGACC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUU 198 GCUUCCUGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUU UUGCUCCUGGACCCUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCU 199 GCCAUUAUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAU CCCUGUGGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGU 200 CCUGGGUACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCC CCACUCACCACCUCUGCUAGUUCCAGACACCUCC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCCUGACAGCGUGGGCAACGCCUGCCGCCUGCUCUGAGGCCCG AUCCAGUGGGCAGGCCAAGGCCUGCUGGGCCCCCGCGGACCCAGGUGCUCUGGGUCACGGU 201 CCCUGUCCCCGCACCCCCGCUUCUGUCUGCCCCAUUGUGGCUCCUCAGGCUCUCUCCCCUG CUCUCCCACCUCUACCUCCACCCCCAC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUC 202 CUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGG AUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCA 203 CACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUA UACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACC GAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCCAAC UACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAAACA UUUAUUUUCAUUGCUGCGUCCUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCUCAUUCUU 204 CCACAAGAGAGACCUUUCUCCGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUGUCCUCCCCUGUGGCUGCCUCAGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGAUGGCAGCAttorney Docket No.: 62801.85WO01CCCUCAUCUUCCAAGUUUUGUGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAUGCAUCUG UACUCCUCC CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCUGCCCGUCCUCACCAAGACUGACUGCCUGCUGCUUUGCUAC 205 UGCCCGGGCCCAUGAGACUGACUUCCCACUGCUCUGCCUGCCUCUCCCCACUGCACUGGCA CAGCCCCGCCUUGCCGCUGCUGAUCCAUUGCCGGUGUGACC CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUU 206 GCUUCCUGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUU UUGCUCCUGGACCCUUUAGCCUCUCUGCCCUUCCACUCUCUGACCCC C AAGC AC GC AGC AAUGC AGC UC AAAAC GC UUAGC C UAGC C AC AC C C C C AC GGGAAAC AGC A GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCCCU 207 GCCAUUAUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCCAU CCCUGUGGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCC CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGU 208 CCUGGGUACCCCGAGUCUCCCCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCC CCACUCACCACCUCUGCUAGUUCCAGACACCUCC CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUC 209 CUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGG AUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUC CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCCAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCA 210 CACCCCCACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUA UACUAACCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACC CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC AAUUUCGUGCCAGCCACACCCUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCUCAUUCUU CCACAAGAGAGACCUUUCUCCGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUG 211 UCCUCCCCUGUGGCUGCCUCAGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGAUGGCAGC CCCUCAUCUUCCAAGUUUUGUGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAUGCAUCUG UACUCCUCC CUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCUCAUUCUUCCACAAGAGAGACCUUUCUC CGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUGUCCUCCCCUGUGGCUGCCUC AGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGAUGGCAGCCCCUCAUCUUCCAAGUUUUG UGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAUGCAUCUGUACUCCUCCUUCCAGCCAGA 212 CACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAUGACCUACCCUCGC CUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUAGCCUCUCUGCCCU UCCACUCUCUGACCCC CUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCUCAUUCUUCCACAAGAGAGACCUUUCUC CGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUGUCCUCCCCUGUGGCUGCCUC AGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGAUGGCAGCCCCUCAUCUUCCAAGUUUUG UGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAUGCAUCUGUACUCCUCCGCCUUGGCUCC 213 UCCAGGAAGGCUCAGGAGCCCUACCUCCCUGCCAUUAUAGCUGCUCCCCGCCAGAAGCCUG UGCCAACUCUCUGCAUUCCCUGAUCUCCAUCCCUGUGGCUGUCACCCUUGGUCACCUCCGU GCUGUCACUGCCAUCUCCCCCC CUUUGCAGGAUGAAACACUUCCCCGCUUGGCUCUCAUUCUUCCACAAGAGAGACCUUUCUC CGGACCUGGUUGCUACUGGUUCAGCAACUCUGCAGAAAAUGUCCUCCCCUGUGGCUGCCUC 214AGCUCAUGCCUUUGGCCUGAAGUCCCAGCAUUGAUGGCAGCCCCUCAUCUUCCAAGUUUUGAttorney Docket No.: 62801.85WO01UGCUCCCCUUUACCUAACGCUUCCUGCCUCCCAUGCAUCUGUACUCCUCCCUGGUACUGCA UGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCCCCCGACCUCGG GUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAGUUCCAGACACC UCC CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG UU C C AGAC AC C UC C CAAGC AC GC AGCAAUGC AGC UC AAAAC GC UUAGC C UAGC C AC AC C C C CACGGGAAACAGCAGUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAA 215 CCCCAGGGUUGGUCAAUUUCGUGCCAGCCACACCGAGACCUGGUCCAGAGUCGCUAGCCGC GUCGCU CUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCGACCUCGGGUCCCAGGUAUGCUCCCACCUCCACCUGCCCCACUCACCACCUCUGCUAG 216 UUCCAGACACCUCC CAAGC AC GC AGC AAUGC AGC UC AAAAC GC UUAGC C UAGC C AC AC C C C C AC GGGAAAC AGC A GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGGUC 217 AAUUUCGUGCCAGCCACACCG CAAGCACGCAGCAAUGCAGCUCAAAACGCUUAGCCUAGCCACACCCCCACGGGAAACAGCA GUGAUUAACCUUUAGCAAUAAACGAAAGUUUAACUAAGCUAUACUAACCCCAGGGUUGG 218 GGCCACCGGGCAUGGGAAGUAUGAGAAGGUGCUUGUGGAAGGGGGCCCGGCUCCCUAGGCG UCCCAUCUCGCUUCCUGGGUCUGCAGGUCCAGCCGGCUGGCACCCUCCAUGUACCCAGGGA GAUUCCAGCCAGACACCCGCCCCCCGGCCCUGGCUAAGAAGUUGCUUCCUGUUGCCAGCAU 219 GACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUCCUGGACCCUUUA GCCUCUCUGCCCUUCCACUCUCUGACCCC AGAGCCUACUCUGAUGACCGUGGCCUUGGCUCCUCCAGGAAGGCUCAGGAGCCCUACCUCC CUGCCAUUAUAGCUGCUCCCCGCCAGAAGCCUGUGCCAACUCUCUGCAUUCCCUGAUCUCC AUCCCUGUGGCUGUCACCCUUGGUCACCUCCGUGCUGUCACUGCCAUCUCCCCCCUGACCC CUCUAACCCAUCCUCUGCCUCCCUCCCUGCAGUCAGAGGGUCCUGUUCCCAUCAGCGAUUC 220 CCCUGCUUAAACCCUUCCAUGACUCCCCACUGCCCUAAGCUGAGGUCAGUCUCCCAAGCCU GACAU UCUGCCUGGGCCACAGCCCUCUCACCCUGGUACUGCAUGCACGCAAUGCUAGCUGCCCCUU UCCCGUCCUGGGCACCCCGAGUCUCCCCCGACCCCGGGUCCCAGGUAUGCUCCCACCUCCA CCUGCCCCACUCACCACCUCUGCUAGUUCCAGACACCUCCACGCCCACCUGGUCCUCUCCC 221 AUCGCCCACAAAAGGGGGGGCACGAGGGACGAGCUUAGCUGAGCUGGGAGGAGCAGGGUGA GGGUGGGCGACCCAGGAUUCCCCCACCCC ACCCUUCAGUCCUGCUUGGGAGGACGCAGCCCACUGCCCAGAAACAAGAAACACGAUACCA UUCUGGCCUUCCCCACCCCACA 222 AUAUCACCUCUCAAAAGCAUCACCUCUAUCUGCCUCAUCUCACACUGUACUCUCCAAUAAA GCACCUUGUUGAAAGAC 223 UCUUAGAAGAA 224 AGAAGAUCCAACAGUGUUGGAAUUGGGGAUCACUGGAAGUAAAUUUGAUGUAUCUUCAUUU AACCCUCAUGGGAUUAGCACAUUCACAGAUGAAG 225 UCCCCAACUCUCAUUCAUGAAAAUAAAAAUUGCUGGAGCUUGGC 226 GCGCUGGGCUGUUUUAGUGCCAGGCUGCGGUGGGCAGCCAUGAGAACAAAACCUCUUCUGU AUUUUUUUUUUCCAUUAGUAAAACACAAGACUUCAGAUUCAGCCGAAUUGUGGUGUCUUAC AAGGCAGGCCUUUCCUACAGGGGGUGGAGAGACCAGCCUUUCUUCCUUUGGUAGGAAUGGC 227 CUGAGUUGGCGUUGUGGGCAGGCUACUGGUUUGUAUGAUGUAUUAGUAGAGCAACCCAUUA AUCUUUUGUAGUUUGUAUUAAACUUGAACUGAGA GAAAUACUUCUUCAAGUUAUGAUGCUUGAAAGUUCUCAAUAAAGUUCACGGUUUCAUUACCA 228 CACCCCUGAGGGGGUCAUGUGGUCAAUAAAAGUCCUUAGGUGCUGCCUAA 229 CCCUGUUCCCAGAGCCCACUUUUUUUUCUUUUUUUGAAAUAAAAUAGCCUGUCUUUCA 230 CGACCGCUGGGAGAACAUCAGGUGCACUGUGGACGUGGGUCUGGGGGUCUCACCCGCCCAG CGAGAGCAGAACCAAUCCAGUCAGGAUGUCACUGACUCUAAAUCAGGUGAUUCAAGAUGCC 231CAAAAAUGAUGGAUAGAGAAACAGAAAUCUCUGAAUGUCAGAACCCUGUCUUUUAAAAAGGAttorney Docket No.: 62801.85WO01CAGUCGCUGCCUUCAGGUGGUGCUGCCCCAGAAACUUAAAAUUUAGUCGAGGCAGUUUCAA UUGUUACUGUGGACCGAAUUAGGAUCACAAUAAACGAUAAUGCAGGUUCUUCAA CUGCAGCUGCCUCUGUUCAGCCACUUGCAACACAAUGUUUCCAACUCUCUAACAUGUUUAA CCCUCAAAC 232 AACCCAAGACAAGCCACAUAAAAGCAACCUAAAAAUUAAACUGUCAUCAUAUUAUUUGUUU UAAAACUAUGGAAUAAUAUAUCUGAGGAAGAUUUCUCUCAAAAUUGUUUUUCUCAAUUUCA 233 A CUUUUGUGCGGGGGCCGUGCUCAUCUCCUUUGGUGCCGUCCUGGGCAAGACCGGGCCUACC CAGCUGCUGCUCAUGGCCCUGCUGGAGGUGGUGCUGUUUGGCAUCAAUGAGUUUGUGCUCC 234 UUCAUCUCCUGGGG GCUGUUCUUGCAUAGGCUCUUAAGCAGCAUGGAAAAAUGGUUGAUGGAAAAUAAACAUCAG UUUCUAAAAGUUGUCUUCAUUUAGUUUGCUUUUUACUCCAGAUCAGAAUACCUGGGAUUGC 235 AUAUCAAAGCAUAAUAAUAAAUACAUGUCUCGACAUGAGUUGUACUUCUAAA GCCUGCGGGCCCAUCCUUUGUGCCCACCCGUUCUGGCCACCCUGCCUGGACGCCAGCUGUU CUUCUCAGCCUGAGCCCUGUCCCUGCCCUUCUCUGCCUGGCCUGUUUGGACUUUGGGGCAC 236 AGCCUGUCACUGCUCUGCCUAAGAGAUGUGUUGUCACCCUC CUCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGGUUCCUUUGUUCCCUAAGUCC AACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUCUGGAUUCUGCCUAAUAAAAA ACAUUUAUUUUCAUUGCUGCGUCGAGAGCUCGCUUUCUUGCUGUCCAAUUUCUAUUAAAGG UUCCUUUGUUCCCUAAGUCCAACUACUAAACUGGGGGAUAUUAUGAAGGGCCUUGAGCAUC 237 UGGAUUCUGCCUAAUAAAAAACAUUUAUUUUCAUUGCUGCGUCGAGACCUGGUCCAGAGUC GCUAGC AGGCACCUGGGAAAUGAGGCCCACAGACUCAAAGUUACUCUCCUUCCCCCUACCUGGGCCA GUGAAAUAGAAAGCCUUUCUAUUUUUUGGUGCGGGAGGGAAGACCUCUCACUUAGGGCAAG AGCCAGGUAUAGUCUCCCUUCCCAGAAUUUGUAACUGAGAAGAUCUUUUCUUUUUCCUUUU 238 UUUGGUA AAAAUGACUUCCAGGAAAG 239 AGCAUGACUGACUGUUAAGUUAUAAGAUAUAGUCAUCUAACAAGCUGUGUGGAAACCUAAC UGUCCAGGAG 240 UCACCUGGCCAACCCACUGGGGUAGGGAUCAAAGCCAGCCACCCCCACCCCAACACACUCG GUGUCCCUUUCAUCCUGGGCCUGUGUGAAUCCCAGCCUGGCCAUACCCUCAACCUCAGUGG 241 GCUGGAAAUGACAGUGGGCCCUGUAGCAGUGGCAGAAUAAACUCAGAUGUGUUCACAGAA CCUCUUCUACACCCAUGUGACCACCAUGGGCCAGAGGCUCAGCCAGAAGGCCCCCAGCCUG GAGGACGGUUCGGAUGCCUUCAUGUCACCCCAGGAUGUUCGGGGCACCUCAGAAAACCUUC 242 CUGAGA UUCCUGCCAUAUGGAGGAGGCUCUGGAGUCCUGCUCUGUGUGGUCCAGGUCCUUUCCACCC UGAGACUUGGCUCCACCACUGAUAUCCUCCUUUGGGGAAAGGCUUGGCACACAGCAGGCUU 243 UCAAGAAGUGCCAGUUGAUCAAUGAAUAAAUAAACGAGCCUAUUUCUCUUUGCA CUAUAGACUUUUAUGAUGGAAACACGUGGCACCCAUCUUCCACGUCUGAAGGCAUAACUAG UGAUUCAUUCAACCCCUGUUCUUAACCUCUUCAGUGUG 244 AUGCAGGAUGCGUGCAGCCAACAGUGGCAUGCUGGCUUUUGAG 245 GCAUGGAAAGGAGCCACCUCCACCCCUUUCCCCACCCAUUAGCCUCACUGCUUCAGAAAAA UCUUUCCCACCUUUCAACUUCUUGGAUCACAACUCUGGCCUUCCUAAGCCAUACCCAAGUA CACAUAUAGCACAUUUCACCCAAGGACCUUCCCUCUUUGGACACUAUGUUACAUACCCCUC 246 UUGGCCUUUGAACCUGUGCCAGGAAGUGUGAGCU UUCGAAAGGACCCAAGGAAGUUUGCCAGGGUUAAAGACUUGCUUACUAUGAAUGAAGAAUU GAAACGAGCUAGAAAAGCAUUUGAUGAAGCAAAUUAUGGAUCUUGACACUUUUUGUAGUUU 247 CCGAAAAUUACCAUCUGGGGAAACCAUAUAUAAUAAUUGUAUAUU AGACCCCUAAAGAGUAUCCUGACUACAAGGAUGAAAGAAAUCA 248 CGUCCUCAAGAGCGGCUGGAAGAUGUUGAACAAAAAUGGAUAUUGCCAUGUGACCGACAGU UAAGAAAACAGUCAGUCAUAACCAAAUCUUUUUCUUUUCUUUUCUUUUUUUUUUUUUUUUU 249 UUUUUUUUGAGACAGAGUCUUGCUCAAUGACAUGGAUUUAAAUCAAUUGUUUAAAAAAAAAAAAA 250Attorney Docket No.: 62801.85WO01UUAUCCAUUCCUUUUGGCCCUGCAGCAUGUCAUGCUCCCAGAAUUUCAGCUUCAGCUUAAC UGACAGACGUUAAAGCUUUCUGGUUAGAUUGUUUUCACUUGGUGAUCAUGUCUUUUCCAUG 251 UGUACCUGUAAUAUUUUUCCAUCAUAUCUCAAAGUAAAGUCAUUAACAUCAAAA GGGGAGGGUGUGGUGGGUUCUCCACUCCACUGCCACCCCCAGCGUGGCUGCUUUCAAGUUC UUUGCAAUUAAAGGUUCUGUAUAAAACCAA 252 AUUGAUACGAUCAUCAAGUGUGCAUCACUUCUCCUGUUCUGCCAAGACUUCCUCCUCUUUG UUUGCAUUUAAUGGACACAGUCUUAGAAACAUUACAGAAUAAAAAAGCCCAGACAUCUUCA GUCCUUUGGUGAUUAAAUGCACAUUAGCAAAUCUAUGUCUUGUCCUGAUUCACUGUCAUAA 253 AGCAUGAGCAGAGGCUAGAAGUAUCAUCUGGAUUGUUGUGAAACGUUUAAAAGCAGUGGCC CCUCCCUGCUUUUAUUCAUUUCCCCCAUCCUGGUUUAAGUAUAAAGCACUGUG UGGAAUUUGCCUUCCGAGAAAGAAUCAGUUUUCCAAGUACAAUACUGCUACUGCUUUAUAA AC AUGUAACACUC UUUACUAUGC UUAUUC UUUC UUC UGGUGAAGGAAAUAUUUGC AGAACA UCCACAUUAGCUUCCCCCAGAAGUCUAUUUAAAGCACUUUUUUUGCAACAAUACCGACCUC 254 UCCACCCCACACAAAAAAAAAUAGAGGCUAGUAUUCUUUCAAUUUGGUACUCUGGAAAUAA AUUGAGUAAUGAGUUAA GCCGGGCAGGAGGAAGGAGCCUCCCUCAGGGUUUCGGGAACCAGAUC 255 GCGCAGCCGCUGCCAUGCACCGGUCUGUCCCUGCACCCCAUGGCACCCAGGAUCUGGUCUC GGUGGUCCUUCCCCGCAGGCAGGUGUCAGGACCGGCCUAAUAAACAUGUGUGGCCUCCUCC UCUCGCUUGCUGGGCGGGCCUUUCCGGGGGCGGGGUUUUGAAGCUGAGGCUUCUGAGGCGC 256 CCGCGUCGGGUCCGCCCCCGAGCGCCGAUUGGCUGGUGUGCUGGGCCCAGCAUGGGCAGGG GGCGGUUCCACUUAAAAACCCUGGGACGAGA GGCAAAUUCAGUACUCUUCUGAUUCUUAAAUGCUGAUAGUUCUUGAUUUAUCAUUCCAUUC UACAAAACUGAGUUGCUAUGGAAAUUACUUUCCAUGAGUAAGCUUUUCAAAUACAUGUAUA UGUUGCUGUUUGCUGGCUGCUUUUCAGUUAAAUAGCAUUAUUUAUAGGCCUGUAAAUUGAA 257 AAUUUUGAUUAUUAUGUAUGUCCCAUGAGUAGAUGUAAUAAAUAAAGGGAAAUAUUUGUUU CUUUAA AAUCCUGUUCCUGUGAUCCAAAGAAGAUGGGAAGCGCCAAGGACAGCAAAGGCAUUUUUGA UUGGGGUGGCUGCAGUGAUAACAUUGACUAUGGGAUCAAAUUUGCCCGCGCAUUUGUGGAU GCAAAGGAAAGGAAAGGAAAGGAUGCCAGAGCCCUGAUGAAUCUUCACAACAACAGAGCUG 258 GCAGGAAG AAUCAACCUCUGGAUUACAAAAUUUGUGAAAGAUUGACUGGUAUUCUUAACUAUGUUGCUC CUUUUACGCUAUGUGGAUACGCUGCUUUAAUGCCUUUGUAUCAUGCUAUUGCUUCCCGUAU GGCUUUCAUUUUCUCCUCCUUGUAUAAAUCCUGGUUGCUGUCUCUUUAUGAGGAGUUGUGG CCCGUUGUCAGGCAACGUGGCGUGGUGUGCACUGUGUUUGCUGACGCAACCCCCACUGGUU GGGGCAUUGCCACCACCUGUCAGCUCCUUUCCGGGACUUUCGCUUUCCCCCUCCCUAUUGC CACGGCGGAACUCAUCGCCGCCUGCCUUGCCCGCUGCUGGACAGGGGCUCGGCUGUUGGGC 259 ACUGACAAUUCCGUGGUGUUGUCGGGGAAGCUGACGUCCUUUCCAUGGCUGCUCGCCUGUG UUGCCACCUGGAUUCUGCGCGGGACGUCCUUCUGCUACGUCCCUUCGGCCCUCAAUCCAGC GGACCUUCCUUCCCGCGGCCUGCUGCCGGCUCUGCGGCCUCUUCCGCGUCUUCGCCUUCGC CCUCAGACGAGUCGGAUCUCCCUUUGGGCCGCCUCCCCGC UCCGGGACUUUCGCUUUCCCCCUCCCUAUUGCCACGGCGGAACUCAUUGCCGCCUGCCUUG CCCGCUGCUGGACAGGGGCUCGGCUGUUGGGCACUGACAAUUCCGUGGUGUUGUCGGGGAA 260 GCUGACGU CCCCCUGGCCCCAGAUGGCACUGAGUUUUUCAUUCAUUGAAGAUUUGAUUUCCUUGA 261 GCUGGAGCCUCGGUGGCCUAGCCUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAUAGUCUGAGUGGGCGGC 262 GCUGGAGCCUCGGUGGCCUGGCUUCCUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 263 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGACUACAGUCUGAGUGGGCGGC 264 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAUUAUAGUCUGAGUGGGCGGC 265 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUCUGAAUAAAGUCUGAGUGGGCGGC 266 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU267UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAGAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCCCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGGGUGGGCGGC 268 GCUGGAGCCUCGGUGGCCGAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCCCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGCGUGGGCGGC 269 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAGUAAAGUCUGAGUGGGCGGC 270 GCUGGAGCCUCGGUGGCCUAGCUUCUUACCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGACUAAAGUCUGAGUGGGCGGC 271 GCUGGAGCCUCGGUGGCCGAGCUCCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCACCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 272 GCUGGAGCCUCGGUGGCCUAGCUUCUUACCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAGAGUCUGAGUGGGCGGC 273 GCUGGAGCCUCGGUGGCCUAGCUUCCUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 274 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAUAGUCUGAGUGGGCGGC 275 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCCUACCCCCUUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 276 GCUGGAGCCUCGGUGGCCUAGCUCCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCCCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 277 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGACUAAAGUCUGAGUGGGCGGC 278 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCC UCCUGCACCCCUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 279 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCCCCCCU UCCUGCAACCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 280 GCUGGAGCCUCGGUGGCCUAGCUCCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAGUAAAGUCUGAGUGGGCGGC 281 GCUGGAGCCUCGGUGUCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCCUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 282 GCUGGAGCCUCGGUGGCCUAGCUUCUUACCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAUAGUCUGAGUGGGCGGC 283 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCCUACCCCCGUGGUCUUUGAAUAAAGUCUGGGUGGGCGGC 284 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUGUGAAUAAAGUCUGAGUGGGCGGC 285 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGGCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCCUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 286 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCCUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 287 GUAGACAAGGCAGGGUGGCCUCAGGGAGAUUCCAGGCCAGCCCAAACUACCCUGCAUCCCA ACCCCCAACCCCUGCCCACAGAACCAGCUGAUGGCCCCAGUGCCUGAAA 288 UUGUGAUUCUCAUCCUGGUGUGGGAAGGAAUCCCGCUGUCUCUGGCUGACAAACUCUACUC GGAGCUUACCGAGACGCUGAGGAAAUACGGCACGCUCACCAAUCGCCGG 289 GUGUCCCCAGCUGCCCUGUGGGCUCAUGCCCUUGGCGUGGGCUUGUGCCCUUGCAAGGGCU UGGCCACUUGGCCCUUCUGGAGCAGACACUUUGUGCCCCCCAUCCCCAC 290 CCCUCAAUCUCAGCCCAGUAUCAGCCCCUCCCAUUGCGGGCCUGGGCUAGGGGGACCCAGG CACUCACCGCCUCCUCCCUGGUACACAGGCUUCUGUGGGGCCACCAAGC 291 CCCAGGCACUCACCGCCUCCUCCCUGGUACACAGGCUUCUGUGGGGCCACCAAGCCCCUCC UGUGCCCCCUCCCAUCCAUAGUGCAUGGUGUGUGGUGCCCCCAGGGCUC 292 CCUCCUCUCCCUCACCAGAGGGGAAGAGGGAGAGUGGCAUAGCUCUGUGUCCAGAGUGUCC CCAGCUGCCCUGUGGGCUCAUGCCCUUGGCGUGGGCUUGUGCCCUUGCA 293 UCCACCCCGCCCGGCCGCCCUCGUCUUGUGCGCCGUGCCCUGCCUUGCACCUCCGCCGUCG294CCCAUCUCCUGCCUGAttorney Docket No.: 62801.85WO01CAUAUCCUGGAGCAGGAAAACUUCCACACAUCAUUGGAGGAUCAGAUCUAAUAGCUCAUCA UGCUCGAAAGAAUACAGAACUAGAAGAGUGGCUAAGGCAGGAAAUGGAG 295 GGGAGUCCCUGCCACACUCAGUCCCCCACCACACUGAAUCUCCCCUCCUCACAGUUGCCAU GUAGACCCCUUGAAGAGGGGAGGGGCCUAGGGAGCCGCACCUUGUCAUG 296 CAGACGUGCUCCUGCUGACCUUCUGCGGCUCCGGGCUGUGUCCUAAAUGCAAAGCACACCU CGGCCGAGGCCUGCGCCCUGACAUGCUAACCUCUCUGAACUGCAACACU 297 AUACCCCACCCCGGCUCCUCUGCACCCAGAGCUGGGGGCCACCUCAGAAGUGUCAUCUCUC UCUGAGCACGCAUUCCCCUGCAGCAGUCGAGGACUGAGCAGAUUGAGUG 298 GCCCACUAUUCCACAGGGAAGGUCAGCGCUUCCUUCACCUCCACCGCGAUGGUCCCGGAGA CCACACAUGAAGCAG 299 CUACAAAAGCCCUUUCUCCCCACAAGCCUCUGGGUUUUCCCUUUACCAGUCUGUCCUCACU GCCAUCGCCACUACCAUCCUGUCACCAGUGGGACCUCUUUAAAACAAGC 300 CUCCCAAUGAGGCAGCCAACAACCCAGAGCCCCUCAGCCCCACAAUGGUGCUGUGUCAGGG CUUCUUGAACCUCCUUCUCUGGGACCUUGAAAAUGAAGAGUUCCCUGAG 301 ACAGUCUGAUCACCAGCCAAAGAAAUCAUUUGAUGCUAAUGGAGCAUCUACUUUAUCAAAA CUGCCUACACCCACAUCUUCUGUCCCUGCACAGAAAACAGAAAGAAAAG 302 UUCUGCCUCUGGACUGAACCCCACAUCUGCACCUCCAACAUCUGCUUCAGCGGUCCCUGUU UCUCCUGUUCCACAGUCGCCAAUACCUCCCUUACUUCAGGACCCAAAUC 303 CUCUGAUUCCUCUGGGGAUAUUGGGAAGUGUCCAGUACACCUUCUCCAGCCUCCCGCUUGU GACCGGGGAAUUCCUGGAGCUGGACCUCAAC 304 GGUUUAAUGAAAGCGCAGCUGAGCGACAUACUAAUUUCUGCAAGGAUCAGUCUUCUCGCCG AGUCUUUAAUCCAGCUCAGACAGCAGCCAAAUUGGCAUCCAGAGCUCAG 305 CCUCAUGAUAGCUGCUUGGUGUUCUACAGUGUCUCCAGAUCCAGACCCUCUUAUAUGGACC GCAGGACAAAAGGACUCUGGCCACCCAGCAGGCCAUGGGCAUGCUGUCC 306 UCCAAAAUGAGGAGCAGGAAGCUCCCUACAGCGUGCACGCUCUUUCAGAGAGUGCCAGGAA UUCACUGUAACUGAGAAUGACAAUGAUAAAAUUAUUUUCACAGAUCAGG 307 GCAUUUUAGGACAAAUAAAAGGAAAUUCAACUUUGUACUUGUGGAAACUAAUCCCUAAAUA UGAAUAGGUUUAUAUUGAUUCAUGGGUAACAGGUCCAUAAUAAAUUAUU 308 CUCCUCGGGCCCCAGAGUCUCUGUUUGAUUAUUUAUUUAUUUAUUUAUUUAUUUGCCAAAA AUUCUCCUCUUCAACUUAUAGAAUGCACCUAAUAAAGUAAUUAGUCUUG 309 CUCAGGCUCUCAUACAUUUUGGCCCUGCCUGCUUAAGCCCUCCAGCCCGCCCACUGCCCGU UGCCUUCGUGCUUCGUCAACGUUCUGUGGCCUUGGAGCUCUGUGUCAAG 310 CCCCGAAAGCCGCUCUCUUCCCUCUUCGCCCCUUCGGCUUGGCUCCUACAAGGCCCAGAAA ACCAGCAGGUCCUCCAGCAUCCCCUGCAGCGGUUCCCUGGACGGGCGGG 311 GGUUCAAAUCAGCCUGCUCAUUUCUGAAAGCCAACAGUUUCCACAAAGUGCUCAGAAAAUU UCCCAGCAGCUAGUUAUGUGUAUUGUCCCAUUGCUGGGGAGGGAAAUUG 312 CAGAGCAAAUGGGGGGCUUCACCCUCAUCCCGCAGCUGCAGAGACUGGAAACUGCCUUCAA GGCCACGGCUGGUCAUCUGCUGACCACACCCCAGAUCCGCCCUCUCCUG 313 CCUCCCAGGUGACCAUUCUCUGUACCUUCUUCACCGUGGUGUUUGCCCUCUACCUGGCCCC UCUCACCAUCUCCUCUCCCUGCAUCAUGGAGAAGAAAGACCUCGGCCCC 314 CGGGCCGCCCACGGGCAGCAGGAGGGACAAUGCGGCCAGGGGACGAGCGCCUUCCUUGCCC ACCUCACUGCCACAUUCCAGUGGGACGGCCACGGGGGGACCUAGGCCCC 315 CGCCGCCGACGCCGCCCUCGGCCCAGACCUCGGUGAUCACUGAGGGAUUUCCGCGAGCUCG GCCUCACUUCUGCCCCGACUUGUGGCUCGGACCCAGGGACCUUCAGGGC 316 UUCCUGGUCUCAGAGAGCCAGAAGAGGUGCAAGGGAGCGUGGAUAUUGCCCUGUCUGUCAA AUGUGACAAUGAGAAGAUGAUCGUGGCUGUAGAAAAAGAUUCUUUUCAG 317 AAUCCCUUCAGUUUUAGCUACCAACGGCCAGGAAAAGCCCUCAUCUUCUCUUUCUCUCCUC AGUUUACAUCUUGUUGGUACCUUUCUAGCCUUAGACAAAUGAUCACCAU 318 AAAGUCCAGUAUCCCCCCUGGAGUCACAUUCGAAAGCUGCUUCAAACUCAAAGGAAACAAC CCCAUUGGCACAAAAUGCAGUCCAG 319 UCCAUCGCUUCGAGACGCUCAGCAACCACUUCAUCGAGCUCCUGGUGCCCUUCUUCCUCUU CCUCGGCCGGCGGGCGUGCAUCAUCCACGGGGUGCUGCAGAUCCUGUUC 320 UACGAGCACAACGACUGGAUCAUCCACCUGGCUGGCAAGCUCCUGGCCAGCGACGCCGAGG CCUUGUCCCUGCUGGCACACAACCCCUUCGCGGGCAGGCCCCCGCCCAG 321Attorney Docket No.: 62801.85WO01AGUUAUCGGGGGCUUUGCUGGGACAGCUCUUGGGGCCUGGCUGGGUUCACCCCCUUCCAGC UGAACACCACACUGAGGCAGGGAGUUGGCUCUCUUGGUGGAGAUGACUU 322 GGAUUCCUGAUAUCUGAUGAGAGGUUCAUUCUUGUGUAUUCAGUUAAUGACACCAAAAGGC UCAGCCCACCCCAACCCUAUCUCAUGUUCAGUCUGUCUAAUACAUGCCA 323 UUCACAUGCACCUUCUGCCUGCGCCCGCUCACCAAGGGGUCCUUCCAGGAGCGCGCCGGCA AGCCCUACUGCCAGCCCUGCUUCCUGAAGCUCUUCGGCUGACAGCCCGC 324 AGAAGCUGCUAUUCAUUGGCCAACCUCUGACAAUGGGGCACUUCAGGCUGAGGGCAAAGCU UGGCAAAUGCCAAUCUGGUUAACCUAUCUUCACAUUCCUUAGGGGAAAG 325 CCCGAGGCCCACGGGGCCCGCGCCUGCCUCCCUUCCCCGCCACCGGGCCCUCUGCCAUUAA AGCCUCCGUGCUUCGCUCUU 326 UUCAAUGACCUGGUCCCUUAGAGCUCCAUAUCCCAGUCCCAGCCCUUCUUUGCAGCUGGGC CUCUCUAUACCCCUGGAUGAACAGCUUGCUCAGGCCCCAGGGUGGCUGC 327 CCAGCUGUUCGGUUCUGGUCCAGAGACAUUCCAGGGGUCCAGGGUGUGGGUCCUGGGCUGU CACAGCCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU 328 AAUGGGGUACCUAGUCCCCAGCCUGCUCCCUAGCCAGAGGCUCUAAUGUACAAUAAAGCAA UGUGGUAGUUCC 329 AGAAGCCCCACCGUUACCGGCCCGGCACGGUGGCUCUGCGCGAGAUCCGCCGCUACCAGAA GUCGACCGAGCUGCUGAUUCGCAAACUGCCAUUCCAGCGUCUAGUCCGU 330 ACUCCCUUACCUAGAGCUCCGUCUCUCGCCAUCGGGACCUCCCGGACCUACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 331 CCUACCGACUCGGUGCGCUAUUUCCUGGACCCAUCUACCUCCCCCCAGCACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 332 CCUACCGACUCGGUGCGCUAUUUCCUCGACCCAUCUACCUCCCCCCAGCACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 333 CCUACCGACUCGGUGCGCUAUUUCCUCGACCCAUCUGCCUCCCCCCAGCACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 334 CCUACUUUACCUAGGGCCCUAUCUAUCGCCACCGCAGACUCCCGUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 335 CCUACUUUACCCUAACUUCCAUCCAGCGCAUCAUCAGACUCCUUGGCGUACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 336 CCUACCCCUCCUCGGUUUUUGCAUGCCGUAUGAGCAGACUCCUGGUCGGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 337 UCCCCAGCCCCAGUGAGCUAGCCCCAGACACCUUGGGCCUCCCCAAUGACCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 338 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCAAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 339 UCCCCAGCCCCAGUGAGCUAGCCCCAGACACCUUGGGCCUCCCCAAUGUCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 340 UUCCCAGCCCCAGUGAGCUAGCCCCAGACACCUUGGGCCUCCCCAAUGUCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 341 UCUGCAGCCUCGGGAGCUGGGUCUAUUACACCUUGGAUCUCCCCCCGGAUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 342 UUCCCAGCCCCAGUGUGCUAGCCCCAGACACCUUGGGCCUCCCCAAUGUCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 343 GAUGGAGCCUCGGUGGCCUAUUUCCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 344 CCUACCUUACCUAGGGCUCCGACCCGCGCCGCUUCUGACUCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 345 CCUCCCUUACCUAGAGCUCCGAUCUUCGCCUCGGCAGACUCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 346 GAUGGAGCCUCGGUGGCCUAUUUCCUUGCCCCUUGGGCCUCCCCCCAGCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 347 CCUACCGUCUCGGUGCUCUAUUUCCUCGACUCAUCUGACUCCCCCCAGCACCUCCUCCCCU348UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01CCUACCUUACCUUUUGCUCCAUCCCGCGACGCAUCAGACUCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 349 CCUACCGUCUCGGUGCUCUAAUUCCUCGACUCAUCUGACUCCCCCCAGCACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 350 UCUGCUGACUGGGGGAGCUUGUUCAUUACGACGUAGGCCUCCCCGUGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 351 GAUGGAGCCUCGGUGCCCUAUUUCCUUGCCCCUUGGGCCUCCCCCCAGCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 352 GCUGGAGCCUCGGUGGCCUAGCUUCUUACACCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 353 CCUCCCGACUCUCGGCCCUCCGCCCUGCUACCCCCUGUCUCAUUUUGAGUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 354 CCUACCGUCUCGGUGCUCUAAUUCCUCGACUCAUCUGACUCCCCCCAGUACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 355 GAUGGAGCCUCGGUGCCCUAUUUCAUUGCCCCUUGGGCCUCCCCCCAGCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 356 CCUGCUGUACCUAGGCUUUUGUCCCUGCGACGUGCAGACCUCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 357 CCUGCUGACUCCGGGCGCCUGCUCCAGUCCGCUUGGGACUCCCCCAUCCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 358 CCUACCUUACCUUUGUUCUUUGCAAUUCGACUCUCUGCCGCCCGUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 359 CCUACUUUACCUCAGUACCUUGCUAUUAAACCUUCUGACGCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 360 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUAGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 361 CCUGCCUAACCUAGAGCUCCGGCUACGUCCGCAUGGAACUCCCCUGCGGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 362 CCUGCCGAACCUAGUCCUCCGGCUAGGUCCGCAUGGAACUCCCUUUGGAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 363 CCUGCCGAACCUAGUCUUCCAGCUAGGUCCCCAUGGAACUCCCUUUGGAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 364 CCUGCCGAACCAAGUCUUCCAGCUAGGUCCCCAUGGAACUCCCUUUGGAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 365 CCUACCCGAACUAGACUUCUAACUCGGGCCAUGUCUGACUCCCUUUGGAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 366 CCUGCUGACUCGAGAGCUUUGUCUAGCGCCUCGGCAGACUCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 367 CAGAAUUGCUCUUAUUUUUCGGUCCGCAUCGCCUCGUUCUCCGCGUUUGGCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 368 CAGAAUUGCUCUUAUUUAUCGGUCCGCAUCGCCUCGUUCUCCGCGUUUGGCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 369 CAGAAUUGCUCUUAUUUAUCGGUCAGCAUCGCCUCGUUCUCCGCGUUUGGCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 370 CAGAAUUGCUCUUAUUCAUCGGUCAGCAUCGCCUCGUUCUCCGCGUUUGGCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 371 CAGAAUUGCUCUUAUUCAUCGGUCAGCAUCGCCUCGAUCUCCGCGUUUGGCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 372 UUCCCAGCCCCGGAGUGCCAGCUCCCGUCACCUAGGGCCUCCUUAACGCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 373 CCUGACCGCCCCUCGCCGCCGCACGCGACAUCGGCAGACUCCUGGAGCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 374 CCUACCGUCCGUUGGCCAUAUUUUCGCGCAUCGGGUGCCUCUCGGGCCGACCUCCUCCCCU375UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01GAUGGAGCCUCGGUGCGCUAUUUCAUUGCCCCUUGGGCCUCCCCCCAGCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 376 CCUCCCGUCUCGGUGCUCUAAUUCCUCGACUCAUCUGACUCCCCCCGAUACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 377 CCUACUUUACCCCGGUCUUCAACAGUCGCCAUGUCAGACUCCCUGAUCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 378 CCUACUUUACCCCGGCCUUCGUCAGUCGCCUGGUCUGCCUCCUUUAGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 379 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUUGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 380 CCUCCCGUCUCGGUGCUCUAAUUCCUCGACUCAUCUGACUCCCCCUGAUACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 381 GCUGGAGCCCCGGGGGCCUAGGUCCUUGUCCCUUGGGCCGCUCCCGAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 382 GCUGGAGUCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 383 CCUACAGACUCGGUGCCCUCGCUUCUUGCACCUUAGACCUCCCCCCCGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 384 CCUGCUGACUGGAGGCGCUUGUUCUUUCAAACGGCGGACUCCCCGUGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 385 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 386 CCUGCUGACUCCUGGGCUUCGCCUCGCGCAUCGUGAUCUCCCGUUCGCGUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 387 CCUGCCGCCUCCUGCGCCUCGCCUCGGACACCGUGAUCUCCCUUUUGCGUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 388 GCUGGAGCCUCGGUAGCCUAGCUUCUGGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 389 GCUGGAGCCUCGGUGGCCUAGCUUCUUGUCCCUUGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 390 GCUGGAGCCUCGGUAGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 391 GCUAGAGCCUCGGUAGCCUAGCUUAUUGGCCCUUGGGCAUCCCCCCCGUACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 392 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCUGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 393 GCUGGAGCCUCGGUGGCCUAGCUUCUUGUCCCUUGGGCCUCCCCCGAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 394 GCUGGAGCCUCGGUGGCCUAGCUUCGUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 395 CCUGCUUUACCUUAGCGCCUAACAGUGGCCGCAUCAGACUCCCUUAGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 396 CCUGCUGAAGCUGCACGCCUGUCCCAGCACUCAUCUGACUCCCCUAGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 397 CCUGCUGACGCUAUGCGCCUUACGCUGCGGACGGCAGACUCCCCUAGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 398 CCUGCCUCCUCGGGAGCUGGGCCUAUGACACCUUGCAACUCCCCCCGGAUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 399 UCUGUAGCCUCGGGGGCUUGGCCUCUUACACCUUAGACCUCCCCCCUGACCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 400 CCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 401 CCUACCGUCUCCUGGCCUGUGCACGCGGACGCGUCAGACUCCCCUAUCAACCUCCUCCCCU402UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01CCUGCCGCCUCGGUGCGCUAUUUCCUUGCCCCAUCGACCUCCCCCCAGCACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 403 CCUGCAGACUCGGAACUCUCGCUCUGCGCCUCACGGAACUCCUUUACGGUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 404 CUGACAGCCUCUGAGCUAUGUUACUACCUACCCACUGCCUCUGCCGGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 405 CUGACAGCCUCUGAGCUAUGUUACUACCUACCCUCUGCCUCUGCCGGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 406 CUGACAGCCUCUGAGCUAUGUUACGACCUACCCUCUGCCUCUGCCGGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 407 CUGACAGCCUCUGAGCUAUGUUAAGACCUACCCUCUGCCUCUGCCGGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 408 CCUGCUGACUGGAGGCCUCCUCUCGCGCACCUCCCUGACUCCGUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 409 CCUGCUGACUGGAGGCCUCCUCUCGCGCACCCCCCUGACUCCGUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 410 CCUGCUGACUGGAGGCUUCCUCUCGCGCACCUCCCUGACUCCGUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 411 GCUGGAGCCUCGGUAGCCUAGCUUCUUGCCCCAUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 412 ACUCUUGUCUCGGUGCGCUACCUUCGCGCCCCCUAGGCCUCGCCCCAUCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 413 CCUACCGCCUCGGGUGCUGGGCUAGUGACAUCUUGCACCUCCCCAAUGACCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 414 CCUGCUGACUGGAGGCCUCCUCUCGCGCACCUCCCUGACUCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 415 UCUACCGUCCCUAGGGCUCCGUCAUGCCCCUCAUCUGCCUCCCUUAGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 416 CCUACCUUACCUAGAGCUCCGUCUAUUACCGCAUCAGACCCGUCUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 417 GCUGGAGCCUCGGUGGCCUAGCUCCUUACACCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 418 CCUACCUUCCCUUGUGCGCCUACCAGCCGCGCAUCUGUCUCCCUUAGCAACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 419 GGUGUAGACUCGGUGUCCUCGCAUCAUGCCCAGGGUGCCUCCCGUAAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 420 GCUGGAGCCUCGGUGGACUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 421 CCUGCUGACUGCGUGGCCUUGCUCUGGGCCGCUUGGGACUCCCCCCGCCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 422 CCUGCUGGCUCGGUGCCCUAUCUCCUCGCCUCGUCUGCCGCCUCCGUGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 423 CCUGCAGCCUCGGGGCCUCCUGCCGCGACACCGUCAUCUCCCCCUGGCCUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 424 CCUGCAGCCUCCCUGCGCCCUGUCGCGACACCAUCAUCUCCUACGGGCAUCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 425 UCUCCAGCCCCAGUGAGCUAGCUCCAUACACCUUGGGCCUCCCCCACGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 426 CCUGCCAGACCUUAGUAGCUGGCUAGCGCCGCUUCAGUCUCCCUUAUCGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 427 CCUACCGUACCUUAGUACUUGUCUAGGGGCGCAUCUGACUCCCUUAAGGACCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 428 CCUACCGACUCGGUGCGCUAUUUCCUGGCCCCAUCUACCUCCCCCCAGCACCUCCUCCCCU429UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01GAGAUGCCCAUCAGUCGAUGUCCUCGGCCACCGACCCGCCUAGCCAAUCGUCGCAGGACCU CCCCUUGAGUCUAAACCUGCCCCCCACUAUUUCAUACAUCAAAGUGCUC 430 CAGGACGACGGCCGGGGUCUGGUGCUUCCUGGCUACAAGUACCUCGGACCCUUCAACGGAC UCGACAAGGGGGAGCCCGUCAACGCGGCGGACGCAGCGGCCCUCGAGCA 431 UGGUGGAAGUGGGGGUGGUUGCAGUCAGUACAGUAGUGGAAGUGGGGGAGAGGGUGUUAGU GAAAGACACACUAUAUGCCAAACACCACUUACAAAUAUUUUAAAUGUAC 432 AUCCCCCGCGGAAGCUGCUCGCGUGGCAACUGUGGGGACCCAGACAGGUUAUCAAAGGCAC CCGGUCUUUCCGCCUCCAGGAGUAUCCCUGCUAGUGAAUUCUAGUGGGG 433 AGUUUCUAAACUUUCAUUUGGUCGCCAAUCAGUUUACUCUCUCCCACCAGAUUCUGAUUAU CUAGAUGGUUACGAGAAUCAGUACUCAGUGAUUAUGGAUGAUUUAGGAC 434 ACUGCUGGCCGCCACUUCUGAGCUAGACUGCCAACAAGGUACUCGGGCCCUGUUACAAACC CUAGGGAACCUCGGGUAUCGGGCCUCGGCCAAGAAAGCCCAAAUUUGCC 435 AUUUGUUUUUGUAAUUCUUUAGUUUGUAUGUCUGUUGCUAUUAUGUCUACUAUUCUUUCCC CUGCACUGUACCCCCCAAUCCCCCCUUUUCUUUUAAAAUUGUGGAUGAA 436 UUGGGCGACACAGCCUGGGACUUUGGCUCCAUUGGAGGGGUCUUCAACUCCAUAGGAAAAG CCGUUCACCAAGUGUUUGGUGGUGCCUUCAGAACACUCUUUGGGGGAAU 437 UGGUCGUGUGGAGAGAGGUCUCAGAAUGGUAUGACAAUUAUGCCUACUACCCGGAGACACC GGGGGCCCUUGCAUCAGCCAUAAAGGAGACAUUUGAGGAGGGAAGCUGU 438 GUCCAGGAAUUUCAUUUCAUCCAAAACUUCGCCCCAUUCUUUUACCCAACAAAAGUGGGAA GAAGGGGAAC AGUGC C GAUC UAAC AUC UC C GGAGAAAAUC C AAGC AAUA 439 ACUUUGCCCCUGCAUGGUCAAUGACAAGGAAUCUCUUUCCUCAUUUAUUUCAAAAUCCGAA UUCCACAAUUGAAUCACCGCUGUGGGCAUUGAGAGUCAUCCUUGCAGCA 440 GAUAGGACAACCUGCUAUUAAACCAAAAUGUCCUUCCGCAGCCUUAAGAGAGGCCAUUGAA UUGGCGUCCCGUUUAACAUGGGUAACUCAAGGCAGUUCGAACAGUGACU 441 GUACUUUGGGCUGGCGGUUUAGAGUUGACCACUAUGCGUUAUUUUGUUAAGAUUGGAGCUG UUAAACAUUGCCAAUGUGGUACUGUUGCAACAUGCUACAAUUCUGUUAG 442 GCCUCUUGCUUUUUCACAUGUAAUAGUAAUGCUAAUCUCUCUAUGUUACAAUUAGGUGUUC CUGACAAUUCUUCAACUAUUGUUACGGGUUUAUUGCCAACUCAUUGGUU 443 GUCAAAGGCAUCUCCAUCCAACCGCUUCGUCUAUUGUGCACCAACUCAUAGACUUGUAGGU GAUAUGGAUGAGAAAGUUGAUGGUGCCGUUGUUGUGUCAGCUUAUAAUG 444 CACGCCUGACGCGUACCACAGGCCUGACAGGCCUGACACGCCUGACGCGUACCACAGGCCU GACAUGCACGACGCGUACCACAGGCCUGACGCGCACCACAGGCCUGACA 445 UGUGGGCGCCCCGAUGGACAUGACAAUGCUCCCUGAUGACACCCUGGUGUUGGACUUUGCG CUGACGUGCAACUGGAAUGGGACCUACAUAUGCCAUCUUUCUGCCCCAG 446 CGCGGCUGUGCCGCGACUCCUUCGCGGGCUCCAUCCGGCACCUCGUCGCGCUGCGCGAGGA GCCCAAGAUCGAGCUGCUGCCGCUGGAGAUGUACGCGGACCCCGACCGC 447 GAGUUCUGCUCGCGGCUGUGCCGCGACUCCUUCGCGGGCUCCAUCCGGCACCUCGUCGCGC UGCGCGAGGAGCCCAAGAUCGAGCUGCUGCCGCUGGAGAUGUACGCGGA 448 AAGUUCUCCAUUUUUUUCUAUUAUAAUAGGACAUGUACCUUCUUUUAUUUCAUCUAUAACU ACGUGUAACAUAUUUUGUUUAAUUGUUUCAUCUGUUAAGUUUGACACUA 449 CCUGUGGGAGGACCAGACUCUGCUGCGGGCAACCGCGAACACCAUAACGGCCCUGGGCGUU AUCCAGCGGCUCCUCGCGAACGGCAACGUGUACGCGGACCGCCUCAACA 450 GCUUCCUCUUCGCUUUCCUGUCGGCCGCCGACGACCUGGUUACGGAAAACCUGGGCGGCCU CUCCGGCCUGUUUGAGCAGAAGGACAUUCUCCACUACUACGUGGAGCAG 451 GCAACAGGGGCUUGGCCUGCGUCGGUGCCCCGGGGCUUCCCGCCUUCCCGAAGAAACUCAU UACCAUACCCGGAACCCCAGGGGACCAAUGCGGGUUCAUUGAGCGACCC 452 UCCCCCUUUGUCGUUCGCGACCCCAAGACCCCCAGCACCCCGUGAGUCCUCGGCGGGUCCC UCCGCGGCCGUCUCUCGUUGCCCCCCUUUCCCCCUUCCCGGGUGGUUCA 453 CAUUCCACCCCGGCCAGGUCCAGGAGGGUGCAAAUAUUCUCCAGGCGCUGCACCUCAGAGA CCUCCUGCUCAAAGAGACCUCCCACCGCCACGUAGACGCGGGCCACCGU 454 UGUAGUAUCAUAGAUAAGUAUUUACUUUCUUCUAUAAAAUGGAUUUUAUUCGUAGAAAGUA UCUUAUAUACACAGUAGAAAAUAAUAUAGAUUUUUUAAAGGAUGAUACA 455 CAACUCCAAAACGACGUUGACGACGUGACGGUGUUUUUCGUCCCGCUUGUUGGCCACCGUG456GGUCCCGGCGCGGUGUUAGACAUGGGGCAGGCCGUGGGGGGAGGACGAGAttorney Docket No.: 62801.85WO01AAAUAGCACGAUAACUUUUCUGUGCUUUUUUUUGAGACGUUUUAGAAGAGCUUUUUUCUGC UCAGAGCGAAAAAAUGAUAGCCCUGAAAAUCUCGACGAGUCUGGCCGAG 457 CUCGUCGUGCCUCUUCCCCCCUCCGGGAGAGGGGACGUCGGGGCCCUCCGUCGCACCGGGC CGAAGCCAGUGAAAUGUUUACUACACUGUCAUCAGAAUAUAUGAUGUAU 458 CUACCUUGGCACCUCCGGAUAGAAGUGCCGUGGGUGUUUCUCCUCCGCCACUCGUCAGCUC GCUGGUGGGAGUACACACGGUAGUAGUAGUUGGGGAGGAAGAGGCCGCA 459 UACAGAUUUAGAUGGAUUUAUAGACAAUACACUUAUAAACAAUACACAGGAAGACAGGGAG ACAGCUCAACAAUUAUUGCAAGUACAAACAGCACAUGCAGAUGCACAGA 460 UCCACCCCCCCCGACUCACCAGGAGGACAAGCAGACUCAAACGCCUCCUCCCAGACCCCCG CCACCACCACUGACUCCACGACCAGACAGUCGCCCAGAAAACAGUCACA 461 CAUGCCUGUUCCCAGGCAGACGGCCAAGUUCCACAGGCAGACGGCCAAGUUCCUGGGCAGU CUGCCAAGUUUCUAUUUUGGACACGCGCACUUCCUGUUCCUAACCGCGG 462 CCCUCCGACGGCUGCCGGCUCUCCCGGCUGCGCCAGAGGCGCCCGGAGAUAGAGCACCAUG GCCUAUGGCUGGUGGCGCCGAAGGAGAAGACGGUGGCGCAGGUGGAGAC 463 GGCCUAUGGCUGGUGGCGCCGAAGGAGAAGACGGUGGCGCAGGUGGAGACGCAGACCAUGG AGGCGCCGCUGGAGGACCCGAAGACGCAGACCUGCUAGACGCCGUGGCC 464 CAGCCCCCGAAGGCCCCGGAGGCCCUCCGCAGCACGCCCCGCCCAACCCUCCUCCGGAGGG UGACCACCAGCCGCCACGGCGUGGUGGUGGGGCCGGUGGCGCCGGAGAU 465 AGGCCCCGGAGGCCCUCCGCAGCACGCCCCGCCCAACCCUCCUCCGGAGGGUGACCACCAG CCGCCACGGCGUGGUGGUGGGGCCGGUGGCGCCGGAGAUGGCCACGCAG 466 UCAUCGAGACACGUGGUGCCAGCAGCUGUAAACCCGGAAGUCGCUGACACACGUGUCUUGU CACGUGGGUGCUGCGUCACAGCCGCCAUUUUGUUUUACAAAAUGGCCGA 467 GAGGAGAC GC C GAAGGGC GC GGUGGAGGAGAC GCGCCGCGGCGC GGAGAUGGC GAC GGAGG AGACCUCGCAGACGCCGAGCUGCUCGCCGCGCUGGAAGACGACGCAGAG 468 AUGACGGCCACCCAGUUCACGCUACGCAUACUGUACGACGAAUUCCAGAGACACCUAAACU ACUGGACUGCCUCUAACAACGACCUAGACCUAGCCAGAUACCUGGGUGC 469 CUUGCCAGCUCUGCCGGCCCCGGCAGACCCUAAACCGGCACCACGGCGUGGUGGUGGGGCA GAUGGAGGCGCCGCCGCUGGGGCCGCCGCCGACGCAGACCAUACCGGGU 470 AACAAUCCUGCCUACCAUUGCCUCCAAAUACUUGCAACUACCUUAGCACCUCAACUAAAAC AAGAAGAAAAACAACAAAUAAUACAAUGC C UUGGUGGUACAGACGC CGU 471 CUCUUCAAAGAAGAUACCUUCCAAGAAACACCACAGACACAAGAAGGAAUCAUCCACCUCA UCCAGCAGCAGCGAGAGCAGCACCCCCCUUACGUCACAGGCCACGCCCC 472 C CCAGAAGAAGAC UUUACAAAAGAAAACAUAGAAGAACUUAUCGC C GC C GCAGAAAAAGCU UCAGAAAGGUAAGGAGAAAAAGAAGAACCUUACCUCUUAAACAAUGGCA 473 CCUUCCAAGAAAUCCCAGACCAGCAAAACAUCCAGCAACUCCUCCACCAGCAGCAGCAGCA ACAGCAGCACACAAAGCUCCAGCUUCUCCAGCUCAUCAACAACUUAAAG 474 UUAGUGGCACGUCAACCCCAAGCGCUGGCCCAGAGCCAACCCUAAUUCCGGAAGUCCCGCC CACCGGAAGUGACGUCACAGGAAAUGACGUCACAGGAAAUGACGUAAUU 475 UCGCCAGACGGACGUGCUUUGCACGUCCGGCCCCACCGAGCGAGCGAGUGCGCAUAGAGGG AGUGGCCAACUCCAUCACUAGAGGUAUGGCAGUGACGUAACGCGAAGCG 476 UCAAAGACUGCUAACGACAACAACAACAGUAACUUUCCUUGGACAGCGGCCAGCAAAUAUC AUCUCAAUGGCCGCGACUCGCUGGUGAAUCCAGGACCAGCUAUGGCCAG 477 AUCUGACGCACGUGUCGCAGACGCAGGAGCAGAACAAGGAAAACCAGAACCCCAAUUCUGA CGCGCCGGUCAUCAGGUCAAAAACCUCCGCCAGGUACAUGGAGCUGGUC 478 GGCUGAUGAACCCUCUCAUCGACCAGUACCUGUGGGGACUGCAAUCGACCACCACCGGAAC CACCCUGAAUGCCGGGACUGCCACCACCAACUUUACCAAGCUGCGGCCU 479 CCCUCUCAUCGACCAGUACCUGUGGGGACUGCAAUCGACCACCACCGGAACCACCCUGAAU GCCGGGACUGCCACCACCAACUUUACCAAGCUGCGGCCUACCAACUUUU 480 CUGGACCUGCGGACAGCAAGUUCAGCAACAGCCAGCUCAUCUUUGCGGGGCCUAAACAGAA CGGCAACACGGCCACCGUACCCGGGACUCUGAUCUUCACCUCUGAGGAG 481 GGACAGCAAGUUCAGCAACAGCCAGCUCAUCUUUGCGGGGCCUAAACAGAACGGCAACACG GCCACCGUACCCGGGACUCUGAUCUUCACCUCUGAGGAGGAGCUGGCAG 482 ACCGCAUCUACCGCAUCCUGGAGCUGAACGGCUACGAACCUGCCUACGCCGGCUCCGUCUU483UCUCGGCUGGGCCCAGAAAAGGUUCGGGAAGCGCAACACCAUCUGGCUGAttorney Docket No.: 62801.85WO01GCGCGUGGACCAAAAGUGCAAGUCGUCCGCCCAGAUCGACCCCACCCCCGUGAUCGUCACC UCCAACACCAACAUGUGCGCCGUGAUUGACGGGAACAGCACCACCUUCG 484 UCAAAGAGUUCUUCCGCUGGGCGCAGGAUCACGUGACCGAGGUGGCGCAUGAGUUCUACGU C AGAAAGGGUGGAGC C AAC AAAAGAC CCGCCCCC GAUGAC GC GGAUAAA 485 UCAGAAAGGGUGGAGCCAACAAAAGACCCGCCCCCGAUGACGCGGAUAAAAGCGAGCCCAA GCGGGCCUGCCCCUCAGUCGCGGAUCCAUCGACGUCAGACGCGGAAGGA 486 CAACCUCUCUGAGGGCAUUCGCGAGUGGUGGGACUUGAAACCUGGAGCCCCGAAGCCCAAA GCCAACCAGCAAAAGCAGGACGACGGCCGGGGUCUGGUGCUUCCUGGCU 487 GAGGGCAUUCGCGAGUGGUGGGACUUGAAACCUGGAGCCCCGAAGCCCAAAGCCAACCAGC AAAAGCAGGACGACGGCCGGGGUCUGGUGCUUCCUGGCUACAAGUACCU 488 UUCAGGAGCGUCUGCAAGAAGAUACGUCUUUUGGGGGCAACCUCGGGCGAGCAGUCUUCCA GGCCAAGAAGCGGGUUCUCGAACCUCUCGGUCUGGUUGAGGAAGGCGCU 489 UUGACGGGAACAGCACCACCUUCGAGCACCAGCAGCCGUUGCAGGACCGGAUGUUCAAAUU UGAACUCACCCGCCGUCUGGAGCACGACUUUGGCAAGGUGACGAAGCAG 490 CCGAGGUGGCGCAUGAGUUCUACGUCAGAAAGGGCGGAGCCAGCAAAAGACCCGCCCCCGA UGACGCGGAUAUAAGCGAGCCCAAGCGGGCCUGCCCCUCAGUCGCGGAU 491 AACAUCCGCCUCCUCAGAUCCUGAUCAAGAACACUCCCGUUCCCGCUAAUCCUCCGGAGGU GUUUACUCCUGCCAAGUUUGCUUCGUUCAUCACACAGUACAGCACCGGA 492 GCGGCAGCAAGGUGCGCGUGGACCAAAAGUGCAAGUCGUCCGCCCAGAUCGACCCCACCCC CGUGAUCGUCACCUCCAACACCAACAUGUGCGCCGUGAUUGACGGGAAC 493 CGCCGAGUUUCAGGAGCGUCUGCAAGAAGAUACGUCUUUUGGGGGCAACCUCGGGCGAGCA GUCUUCCAGGCCAAGAAGCGGGUUCUCGAACCUCUCGGUCUGGUUGAGG 494 AUCAUGACCUGACAAAUGAUUACAAGAAGAAGGGGGCCUUCUACACUUAUAACGCAGCUGA CAAGAUACUGUUGCGUAAAUUGGAGAAAGAACAUUCCAUUCCCGCCAAG 495 UAGAAGAAGCAGGCAACUUUGGAACACAAGUAAACUCAUUCAAAGCAAUCAUGAGCGGCCA AGC AAUC AGAC UAGAC C AAAAAGGAAAAGGC AGC AAAC AAAUAGAAC C A 496 ACCAGACGAAGAAAGAGAAGAAGAAGAACACACACCACCUAACUCUCCAAAACCAACAACU CAACAACAAUCUCUGGCUGAAAGCCUUGAUCCUGAUGAUCAAGAAUUUG 497 GCCUGGAUGGAGAAUCUGUACGAGGACAGCCAGGACCCGUGGAUCCCGUACAUGAGCGGGA UGAC GAC UCC GAC AGCGAGC GAACGAUCGACAC CAGUGAUGGAGAGCAU 498 ACCCUUUGCUCGCUCGUCUAGCGUCAUGUAACGACGGCCUCCUCCCUGCGGGUCAGCCCCU UACUGAUGGUGGAACUCCGUUGUCAUCCUAUAACGGUCCUUUUUCGGAUCGCAAUCUCACC 499 GCUGGAGCCUCGGUGGCCUAGCUUCUUGUCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCUGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 500 GCCGUCUCUUCUUCGCGGCGACGAGUUCUAUCCCCCUCCCCCCCUCAUGUCCUCCAGCGCU CACCCUGCCCGCCCUGGAUGAAACCCCCCAAAACUUCGAGUCUGCGGGUGGUAAUCAGACC 501 GCCGUCUCUUCUUCGUGGCGACGCGUUCUAUCCACUGUCCCCCCUCAUGUCCUCCUUCGCU CCCCCUGCCCCUCGAUGAUGUUACCCCCCAAAACUUCGAGUCUGCGGGUGGCAAUCUGACC 502 UCUGUGUCCUCUUCCUGGCCGAUGGUUCUAACCGCGAGCCCCCCUCAUGUGGUCCGACGCU CACGCUGUCCGUCACGUCUGGCACCUCCCAAGACAUCGAGUCAGUAGGUGGUCAUCAGCCC 503 UCCGUGUCGUCUUUUUGGCCGAUGGUUCUAACCACGGACCCCCCUCAUGUGGUCCAUCGCU CACGCUGUCCGUCACUCGUGGGACCUCCCAAGACGUCGAGUCAGUGGGUGGUUACCAGAAC 504 UCUGUCUCCUCUUCCUGGCCCACGGUUCUAACCGCGCACCCCCCUCAUGCGGUCCUUCGCU CUCUCUGUGCGGCCUGAGUGGCACCUCCCAAGACGUCGAGUCUGUAGGUGGCGAUCCGCUC 505 AACAUCCUCUCGAUCGGAUCCCAACGUGUUACCCCGGGACCCACUUGGGCGUACGCGGCCC CUCUGACGUUGGAAUUCUGAAGAUCAAAGUUAGUUAGGAGCUUUUAAUUAGAAAUGAGCAC 506 AUCAUCCUCUCGACCGGAUCGCAACGUGUUACCCGGGAAUCCACUGGGGCGUACGCGGCCC UCCUGACGUUGGAAUUCUGUAGAAGAGCGUUAGCUAGGAGCUUUUAAUUAGAAAUGAGUAC 507 ACCAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGCGUACGCGGCCG CUCGGGCGUUGGAAUUCGGCAGAUCACAGUCGGCUAGGAGCUUUUAAUUGGAAAUGAGCAC 508 AACAUCCUCUCGAUCGGAUCCCAACGUGUUACCCAGGAAGCCACUUGGGUCUACGCGGCCC CUCUGACGUUGGGAUUCCCUAGAUGAAAGUGAGCUUGGACCUUUUAAUUGGAAAUGGGAAC 509 AACAUCCUCUCGAUCGGAUCGCCACGUGUUACCCAGGAACCCGCUUGGGCGUACGCGGCCC510UUCUGACGGUGGGAUUCUGUAGAAGAAUGGUUGCUAGGAACUUUUAAUUGGAAAUGAGAACAttorney Docket No.: 62801.85WO01ACCGUACUCUCGGUCGGCUAGCUUCGUGUCCCCUGGGCCUCCCCCCGGCCCCUCCUCCCCU UCCUGCCGCUGGACCCCCGUAGUCUUUGAAUAACGUCUGACUUUGCGGCGAAUAAC 511 AACAUCCUCUCGAUCGGAUCGCUACGUGUUACCCAGGAACCCGCUAGGGCCUGCGCGGCCC AUCCGCGGGUCGGAUUCUGUAGAACACUGGUUGCUAGGAACUGUUAAUUUGAAAUGAGAAC 512 ACCAUCCUCUCGGUCGGAUCGCAACGUGUUACCCGGAAAGCCACUAGGGGCUACGCGGCCC CUCUGGCGUUCGCAUUCCCUAGAUUAAAGUGAGCUUGCACCUGUUAAUUAGAAAUGGGCAC 513 CUCCCCCUCUCGCUCGGAUCGCAACGUGCUGCCCAACAACCCCCUUGGGUGUGCGCGGCCG CCCUGCGGUUCGGAUUCGGUAGAUUAAAGUUAGCUAGGACCUUGUAAUUGGUAAUGAGCAC 514 AACAUCCUCUCGAUGGGAUCGCAACCUGUUAUCCCGGAAUCCACUUGGGCGUACGCGGCCG CUCCCCCGGUGGAAUGCUUUAGAGGACCGUUAGCUAGGAACGUUUAAUUGGAGAUCGGAAC 515 AUCAUCCUCUCGGCCGGAUCUCAACGUGUUACCCAGCAAUCCACUUGGGGGUCCGCGGCCG AUCUCACGUUGGAAUUCUGAAGAUGACCGUUAGUUAGGAGCUUGUAAUUAGCUAUGCGCAC 516 CACAUCCUCUCGCUCGGAUUCCAACGUGUUAUCCCGGCCCCCACUCGGGCGCACGCGGCCC GCCUCGCGUUCGCAUUCCCUAGAACAACCGUAGUUAGGACUCCUUAAUUAGCAAUGCCCAC 517 CUCAUCCUCUCGACCGGAUCGCCACGUGCUACCCGGAACUCCCCUUGGGCGCCCGCGGCCC GCCGGAGGUUGGCAUUCCCCAGACGACCGUCAGUUAGGAGCCGUUAAUUAGCGACGGCCUC 518 AUCAUCCUCUCGAUCGGAUCGCUACCUGUCACCCAGGCACCCGCUAGGGCCUGCGCGGCCC ACCCGCGGGUCGGAUUCUCUAGAACACUGGUUGCUUGGACCGGUUCAUUUGAAACGACCAC 519 ACCAUCCUCUCGGUCGGAUCGCAACCUGUUACCCGGAACCCCACUCGGGGCCGCGCGGCCC CUCUGGCGUCCGCAUUCCCCAGAUUAAGGUGAGCUUGCAACUGUUAAUUAGAGAUGCGCCC 520 ACCAUCCUCUCGAUGGGAUCGCGGCUUGUGACCCGGGGACCCACUGGGGCGUACGCGGCCG CCCUCGCGUCCGCAUUCAGAUGAUCACCCUUCCUUAGGAACGGGUAAAUGGAGAUGGGGAC 521 AACAUCCUCUCGAUCGGCUAGCAUCGUGUUACCCAGGCCUCCACUUGGGUGUACGCGCCCG UUCUGACGUUGGAACUCUGUAGACGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 522 CUCGGCCUCUCGCCGGGCAUCCCUGUUGUAUUCCCCAACCCCACUCGGGCCGCCCGCAGCC ACCCCGCGGCCCCUUUCCUCACACUUUCCCGCCAUUGCACCCGGUGGGUGAACACCCGCCG 523 CUCGGCCUCUCGCCGGGCAUCCCUGCUACAUCCCCCAACCCCAUCGACCCCGCCCCGGCCC ACCCCGGGGUCGCUUUCCUCACACCCCCCCGGCUUUGCACCCGGUAGGUCACAAGCGGGCC 524 CUCAGCACUCGGGCGGGCAUCCCUGCUAACUCCCCGGCCCCCACUCGGGCCGCCCCGGCCC CACCCGGGUCCCCUUUCCUCACACCCCCCCGGCUUUGCCACGGUUCGAUGAACACCCGCCG 525 CUCAGGCUCUCGCCGGGGAUCCCUGCUACAUUCCCCAACCCCACUCGGGCCGCCCCGGGCU CCCCCGGGCCCCCUUUCCUCACACCCCCCCGGCUUUGCACCCGGUGGGUGAACACCCCUCC 526 CUCCCCCUCUCGCCGGGUGUCCCGGCUAACUCCCCGGCCCCCACUCGGGCCGCCCGGGCCC ACCCGCGGUCCCCUUUCCUCACACCCCCCGUUAAUUGCACCCGGUAAUUAGUGACGCGGCC 527 ACCGUACUCUCGGUCGGCUCGCAUCGUGUUACCCAGGCCUCCCCUCGGGUGCUCCUCCCCU UCCUGCCGCUGGACCUCCGUAGUCUUUGAAUAACGUCUGACUUUGCGGUGGAAAUAAC 528 AACCUGCCCGCGAUCGGAUCGCAACGUGGUACCCUGGAAUUCACUUGGGUGUACGCGGCCG UUCUGACGCAGGAAUUUUGUAGAUGAAAGUUAGCUAGGAGCUUAUAAUUGGAAAUGAGAAG 529 ACCAUCCUCUCGAUCGGAGCGCAAGUCGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG GUCCAACGUUGGAAUUCUGUUGACGAAAGUUUGCUAGGAGCUUUUAAUUGGGAAUGAGAAC 530 UACAUCGUCUCGAUCGGAUCGCUACGUGUUACCCAGGAAUUCACCUGGGUGUACGCGCCCG UUCUGACGUUGGAUUUCUGUCGAUGAAAAUUAGCUCGGAGCCUUUAAUUGGAAACGAGAAC 531 ACCCUUUGCCCUCUCCUCCAUCGGGAUAUAAAGACCACCCGCUUCCAUCGGGUGAGCCCCU AAGCCAUGGUUGUACAGCACUAUCAUCCUUCAGCGGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCUCGCUUCCUUCGGGAUCUGGACCAGCGGACCAAGGACCUCUUUGAACUUUUCC 532 AACUUUUCUCAC ACCCUUUGCACACUCCUCCAUGGUGAAAUAAUGACCACCCACUUCCUUUGGGUGAGCCCCU AAGCCAGGGUUGAACUGCACUACCCUCCUUAUACGGUCCUUUUUCGGAUCGCAAUCUCACC CUGGUGCCGCGUUUGCUUCGGGAACUGCACCCGCGGCCCAGGGCCGGCCUCGACCUUUUCU 533 ACCUGUUCUUAA UCCCUUCGCCUACUCCUCCUUGGUGACAUAACGAACGCCCACUUCCUUCGGGUGAGCCCUU AAGCCAUGUUUGUACUGCACGAUCUUCCAAAUACGGUCCUUCUUCGGAUGGCAAUCUCACC CUGGUGCCGCGGUUCCUUCGGGAACUGCACCCGCGGACCAUGGCCGUCUUUUAACUUCUCU 534 AACUGCUCUUAC ACCCUUUGCCCACUCGUCCAAGUUGAUAUAAAGACAAGACCCAUCCAUCGGGUGAGCCCCU AAGCCCUCAUUGUACUGCACUAUCAUUCUAAGACUGUACUUCUUCAGAUCGCAAUCACACC 535Attorney Docket No.: 62801.85WO01CUGCUGCCGCGCUUACUUCGGGAACUCCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU AACUGUUCUUAC ACCCUUGGCCCACUCCACCCUGGUGAUAUAAAGACCACCCACUUCCUUCGGGAGAGCCCCU AAGCCAUGGUCUUACUGCAGUAUCAGCCUAAGACGGUCCUUCAUUGGAUCGCAAUCUCACC UAGGUGCCGCACUUCCUUCCGCAACAGCACCCGCGGAGCAGGGCCAUCUUUGAACUUUUCG 536 AACUGUUCUUUC ACCCUUUGCCCACUCCUCUAUGCUGAUAUAAAGUCCUGCCACUUCCUUCGGGUUAGCGCCG AAGCCCUGGUUGUACUGCAUUAUCAUCCUAAGACGGUUCUUGUUCGGAUCGCAAUCUCACC CUCGUGCGGCGAUUCCUUCGGGAAGUGCACCCGCGGACCAGGGCCGUCCUUGAACUUCGCU 537 AACUGUUCUUAU GAUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCACCAGCCCCUCUUCCCCU GUCUGCUCCCGUAGGCCCGUGGUGUUUUAAUAAAGUAUGAGUGGGCGGC 538 GCUGGAGCUUCGUUGGCCAUGCUUCUUGCCCCUUGGGCCGCCCCCCAGCCCCGCCCCCCCU UCCACCACCCGUACCCCCGUCGUCUUUGACUAAAGUCUGAGUGGGCGGC 539 GCUGCAGCCUCAGUGGCCUAGCUUCUUGCCCCUUGAGCCUCCCCCCAUCCCCUCCUCCCCU GCCUGUACCCGUAACCCCGUGGUACUUGACUAAAGUCGGAGUGGGCGGC 540 GCUGGAGCCUAGGUGGCCAUGCUUCUUGCCGCUUGGGCCACCCCCCAGCCCCUCCUCCCCU UCCUCGGCCCAUACCCCCGUGGUGUUUGAAUACAGUCUGAGUGGGCUGU 541 GCCGGAGCCUCGGUAGCCAUGCUUCUUCGCCCUUGGGCCUCCCCCCAGGCCCUCCUCCUCU UUCCGCACCAGUACCCCCGUGGUCUUUGUACAAAGUCUGAGUGGGCGGC 542 GCUAGAGCCUCGGUGGCCCUGCUUCUUGCCCGUUGGGCCUCCCCUCAGCCCCUCCUCUCCU GCCUGCACCCGUACCCCCGUGGUCAUUGUGGAAAAUCUGAGUGGGCGGC 543 GCAGGAGCCUCGCGAGCCUAUCUUCUUGCCCCUUGGGCCUCCCCCCAACCCUUCCUCCCCU UCCUGCACCCGUAAGCCCGUGGUCUUUGCAUUAAGUCUGAGUGGGUGGC 544 UCUGGAGCCUAGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCGGGCCCCUCCUCCCCC UCCUGCACCAGUACCCCCGUGGGCUUUGUAUAAAGUCUGAGUGAGAGGC 545 GCUGGAGCCUCGACUGCCUAUCUUCUUGCCCCUUGGUGCUCCCCCCAACCCCUCCUCCCCU UCCUUCACCCGUACCAACGUGAUCUUUGAAUAAAGUCUCAGUGGGCGGC 546 AACAUCCUCUCGAUUGGAUCGCAACGUGUUCCAAAGGAAUUCACUUGGGUGUACGCGGCCU UUCUGACGAUGGAGUACUGUAGAUGAAGGUUAUCUAGCAGCUUUUAAUUGGAAAUGAGAAC 547 AACUUCCUCUCGACCGGUUCGCAACGUGUUACCCCGGAAUCCAUUUGGGUGUUCACGGCAG UACUGACUUUGGAAUUCUGUAGAUGAAAGUUAGUGAGGAGCUUUUAAUUGGAAAUGAGAAC 548 AACACCGUCACGAUCGGCUCGCAAAGUGUUACCGAGGAAUCCACUUGGGUGUACGCGGCCG GACUGACGUUGGAAUUUUGUAGAAAAAAGUUAGCAAGGAGCUUUUAAUUGGAAAUGAGAAC 549 ACCCUUUGCCCACUCCUCCGUGGUGAUAUAAAGAACACCCACUUCGUUCGGGUUAGCCCUU AAUCCAUCGUUGGACUGCACUCUCAUCCUAUACCGGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACCGAACCCGCGGACCAGGCCCGUAUUUAUGCUUUUCU 550 AGCUGUUCUUAC CACCUUUGCCCACUCUUCCAUGGUGAUAUUAAGACCAACCGCUUCCGCCGGGUGAGCCCCU AGGCCCUGGUUGUACCGCACUAUCAUCCUAAGACUGUCCUUCUUCGAAUCGCACUCUCACG CUGGUGCCGCGAUUCCUUAGGGAGCUGCACCCGCGGACCAGGGCCGUCUUUGAACUUAUCU 551 AAGUGUUCUUAC AGCCUUUGCCCACUCCUCCAUGGUGAUAUACAGACGAGCCACUUCCUGCGGGUGAGCGCCC AAGCCAUGGUUGGACUGCACUAUCAUCCUAAGAGGGACAUUCUGCGGAUCGCAAUCUCACA CUAGUGCCGCGCUUCCUUCGGCAACUGCACCCGCGGGCCAGGACCGCCUUUGAACUUUUCU 552 AACUGUUCUCGC GCUGGAGCCUCGGUGGCCUAGGUUCGUGCCCCUUGGGCCUCCUCCCUGCCUCUCCUCCCCU UGCUGCACCGGUACCCCCGUGGCCUUGGCAUAAAGCCUGAGUGGGUGGC 553 GCUGGUGCCUCGGUGGCCUAGCAUCGUGCCUCUAGGGCCUCCCCCCCGUCCCUCCUCCCCU UCCUGCACACGAGCCCCCGUGGUCAUUGAAUAAAGUCUGAGUGUGCGGC 554 GCUGGAGCCUCGGUGGCCGAGCUUCGGGCCCCUUCGGCCUCCCCCAAGCCGCUCCUCCCCU UCCCGCACCCGAACCCCCGUUGUCAUUCAAUAAAGUCUGAGUGAGCGGC 555 CUUGUACUGCAUGCACGCAAUGCUAGCUGCCCGAUUCCGAUCCUGGGUUCCCCGAGUCUCC GGCGAUCUCAGGUCCCAGGUAUGCUCAGACCUCCACCUGCGCCACUCAACACCUCUGCUAG 556UUCCAGACACCUCCUUCGAGCCUAACACCCGCCCCACGGCCUUGGCCAAGAAGUUGCUUCCAttorney Docket No.: 62801.85WO01UGUUGCCUGCAUGACCUACUCUCGCCUCUUUGAUGCCAUCUGCUGCCACCUCCUUUAGGUC CUUGACCCUUUAGCCUCUUUGGCCUUCCACUCUCUGACCCC CUGGUACUGCUUGCACGCAAUGCUAGCUGGCCCUUUCCCGUCCUGGGUACCCCGAGUCUCC CCCCACCUCGUGUCCCAAGUUUGCUCCCACCUCCCCUAGCCCCAAUCACCAACUUUGCGAG UGCCAAACACAUCCUUCCAGCCAACCACCCGCCCCCCGGCCCUGGAUAGGACGUUGCUUCC 557 UGUUGCCAGCAUCACCUACCCUCGCCUCUUUGAUGCCAUCCGCUGCCACCUCCUUUUGCUU CUGGACCCCUUGGCCUCUCUGCCCGGCCGCUCUCUGACCCC CUGGAACGGCAUGCACGCAAUGCUAGCUGCCCCUUUCCCAUCCUGGGGACACCGAGUCUCC CCUGACCUUGUGUCCCAGGUCUGAUCCCACCUCCUCCUGCCUCACUCACCACCUCUUCUGG UUCGAGACAUCUCCUUCCCGCCAGACACCCGUCCCCCGGCGCUGGCUAAGAAGUUACUUCC 558 UGUUGCCAGCAUGACCUACCCUCGCCUCUUUGAUGCCAUCAGAUACCACCUCCUUUUGCUC CUGGACCCAUAAGCCUCGCUGCCCUUCCACUGUCGGACCCC AACAUCCUCUCGAUUGGAUCGCAAAGUGUUACCCACGAAUCCACUUGGGCGUACGCGGCCG UUCCGACGUUGGUAUUCUAUAGAUGAAAGUUAGCUAGGAGCUUUUGAGUGGAAAGGAGCAC 559 AACAUCCUCUCGCUCGGAUCGCAACGUGUAACCCAGGAAUCCACAUGCGUGUACGCGGUCG UUCUGACGAUGGAAUUCUGUAGAUGAGGGUUAGCUUGCAACUAUUAAUUGGAAAUGAGAAC 560 AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGACUCCUCUUGGGUGUACGCGGCCG UUCCGAUGUUGGAAUUCUGUAGAUGACAGUUAGCUAGGAACUUUUAAUUGGAAACGAGUAC 561 AACAUUCUCUCGAUCGGACCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGUGGACG UUCUGACGGUGGAAUUCUGUAUAUGAAACUUAGCUAGGAGCUGUUAAUUGGAAAUGAGAAC 562 AACAUACUCUCGAUCGGAUCUCAACGUGUUACCCAGGAAUCCUCUUAGGUGUACACGGCCG UUCUGACGUUGGUAUUCUGUAGAGGACAGUUAGCUGGGAGCUGUUAAUUGGAAAUGAGCAC 563 AACAUCAUGUCGCUCGGAUCGAAACGUGUUACCCCGGAAUCCACUUGGGGUGUCGCGGCCG UUCUGACGUGGGAAUUCUGUAGAAGAAAGUGAACUGAGAACCGGUGAUUGCAAAUCCGCAC 564 AACAUCCGCUCGACCGGAGCACAACGUGUUACCCAAAUUACCACUUGCGUGUUCGGGGGCG CUCUGACGUUGGUAUUCUGUAGACGACAGUUAACUUAGAGCUUUUAGGUGGAAAUGAGAAC 565 AACAUCCUCUCGAUGGCAUCCCAACGUGUCACCCAGGAAUCCACUUGGGCGUACGCGGUCG UUCUGCCGUUGGAAUGCCAUAGAGGAAGGUGAGCUUGGAGCGCUUAAUUGAGAACCAGAAC 566 AACAUCCUUUCGACCGGAUCGCAUCGUGUUACCCCGGAGUCCUUUUGUGUGGUCAACGCCC AUCGGCCGUUGCUAUUCUGUAUACGAAAGUGAGCUAGGAGCUUUUGAUUUGAAAUGAGAAC 567 AACAUCAUUUCGAGCGGAUCGCUUCGUGUCACCCAGGAGUCCACUUGGGUGUUCGGGCCAU UUCGGAGGUUGCGAUUCUAUAGAUGAGCGUGAACUAGGAGCUGUUAAUUGGGAAUGAGUAC 568 AACCUCCUUUCGACCGGAUCGCAUAGUGUUACCCCGGAGCCCUUUUGUGUCGUCAGCGCCC AUCGGCCGUUGCUAUUCUGAAUACGAACGUGAGCUAGCAGCGUUUGAGUUGUAAUGAGUAC 569 GAGAUCGUCUCGAUCGGACCAGUUCGUGUUACCCUGGAUCCCACUUAUGUAACCGCCGACG UCCCGCCGUUGGUAGGCUGAAUACGAAUGUUUGCUAGGAACUUUUAAUUGGAAAUUAGCUC 570 AACAUCCGCUCGACCGGACCCCAACGUGUUACCCCAAUUUCCUCUUGCGUGUUCGGCGGCG CUCUGACGGGGGGAGUCUGUAUACGACAGUUAACUUAGAGCUGUUAGGUAAGAAAGAGCUC 571 AACAUACUCUCGAUCGGAUCCGUUAGUGUUCCCCACACAUCCCCUUGUGUGGUCGCGGUCG GUCCGACGGCCGGAUUCUCUAGACGAUAGUAAGCUAGGAACUUUUAGUUGGCAAGGGGCAC 572 AACAUUCUCUCGAUUGGACCGCAACGUGUUGCCCAGGAAUCCUCUUGUGUAUUCGACGUCG UUCUGACGGGGGGAUCCUGUAUAUGAAACUAAGCUUGGAGCUGUUGAUUAAAGAGGAGCAC 573 CCGCUAAGGUCGCCGGGACUCCCUAGUGUAUCCCCCUUCCCCCUAUAUGCCGUCAGCCGAU CCCCGCGGGCCCCAGGCUCAAUACCUCCGUGUAAUUAGAAUGGGUGGGUAAGGAGCCGGUG 574 GCCCUAAGGUCGCCGGGACUCACUAGUAUAUCCCCGUUCACCCUAUAUGCCGCCAGCCUAU CCCGGUGGGCCACAGGCACAAUACCUCCGUGUAAUUACAACGGGUGGGUAAGGAGCGGGUG 575 CCCCUCGGGUCGCCGGUACUCGCUAGUGUACCCCCCUUCACCGUAUAUGCCGUCAGCCUAU CCCGGCGGGCCCCAGGCACAGUACCUCCGUAUACAUACAACGGGUGGGUAAGGAGCGGGUG 576 GCGCUAAGGUCCCCGGGACUCACAAGUGUAUCCCCGUUCUCCGUAUAAGCGGCCAGCCGAU CCCCGCGGGCCACAGGCUCAAUACGUCCGUAUACAUACAAUGGGUGGGUAAGGAGCCGGUG 577 CCCCUAGGGUCGCCGGGACUCACUAGUGUAUCCCCCUUCACCGUAUAUGCCGCCAACCGCU ACCCCUGGGCCCCAGGCUCAAUACCUCCGUAUAAAUACAACGGGUGGGUAAGGAGCCGGUG 578 AACACCCUCUCGAUCGGACCCCCACGUGUUCCCCCGGGAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUCCUGUAGAUGAAAGUUACCUAGGAGCCUUUAGCUGGAAAUGAGAAC 579 AACGUCCUCUCGAUCGGAUCGCAACGUGUUACCCCGGACUCCACUCGGGUGUACGCGGCCG580UUCUGACGUUGGAAUUCUGUAGAAGAAGGUUUGCUAGGAGCUGUUAAGUGGAAAUGAGCACAttorney Docket No.: 62801.85WO01AACAUACUCUCGAUCGGAGCGCAACGUGUUACCCCGGAACCCCCUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUAAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 581 AACAUCCUCUCGAUCGGACGGCAACGUGUUACCCAGGAAUCCCCUUGGGUGGACGCGGCCG UUCUGACGCCGGAAUUCUGUAGAUCAACGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAUC 582 GACAUCCUCUCGAUCGGAUCGCAACGUAUUACCCGGUAAUCCCCUAGCGUGGACGCGGCCG UUCUGACGCUGGGAUUCUGUAGAUGAGAGUUAGCUAGGAGCUUUUAAGUGGAAAUGAGAAC 583 AACCCCCGCUCGAUCGGACCCCCACGUGUUCCCCCGGCAUCCACUAGGGUGUACGCGGCCG UUCUGACGUUGGCAUCCUGUGGAUGAACGUUACCUAGGAGCCUUUGGCUGGAAAUCUGAAC 584 AACAUCAUCUCCAUCGAAACUCAACGUGUUACCCAGGACCCCACUAGGGUGGACGCCGCCU UUCCGACGUUGGAAUGCUGUAGACGAACCUAAGCUUGGAGCGUUUAGCUGGUAACGAGAAC 585 AACCUCCGCUCGGCCGGACCUCAACGUGUCACCAAAGAAUCCACUAGGGUGUACGCCGCCU AUCUGACGCUGGUAUUCCGUAGAUGAACGCAAACUUGGAGCGUUUAAUUGGAAAUCGGAAC 586 AUCAGACUCUCGAUCGGACCUCAACGAGAUACCCGAGUCUCCCCAUGGGUCUACGCGCCCG GUCUGACGUUCGAAUGAUGUAGAUGGAGGGUAGCUAGGAGCUUUUAAGUGGAAAUCAGAAC 587 AUCAUCCUCUCGAUCGGACCGCACCGUGUCACCAUGGUAUCCGCAAGAGUGUACACGCCCG AUCUGACGUUGGAAUCCUGCAGACGGAAGUCACCUAGGAGCUUUUAAUUGGAAAGGCGCAC 588 GACAUACUCUCGAUCGGACCCCAACGUAUCACCACGGCCCCCCCAGGGGCGUACCCGGCCC CUCCGUGGCCGCAAUUCUGCAGACCACAGGUAACUAGGAGCUGGUGAUCGGAAAUGAGCUC 589 AUCAUACGCGCGCUCGGACCCCCACGUGUUCCCCCGGUAUCCACUAGGGUCUACGCCCCCA UUCUGAGGUCGGCAUCCUGCGGAGGAGCGUUACCAAGGAGCGUUUGGCUGGAAAGCUGAAC 590 AACCGCCGCUCGAGCGGAGCGCACCGUCUCACCACGGAAUCCACUUGGGUCCACCCCCCCG UCCUGCGGUUGGGAUGCAGCAGACCACAGGCAACAUGGACCUUUUGAUUAGCAAUGCGCAC 591 AUCAUACUCUCGGUCGGACCGCACCGUGUCACCAGGAUACCCGCAAGAGUGGACACGCCCG AUCUGUCGUUGGAAUCCUCCAGACGGAACCCACCUGGGACCCUUUAAUUGGAAAGCCGCAC 592 ACCCUCCACUCGAUCGGAGGGCACCGUCUUACCGGGGACUCCUCCUGGGUGCACGCCGCCU CCCUGACCAUGUAAGUCUGUGGACGAUCGUGAGCAAGGAGCUGUUGAUUGGAAAUGAGGAC 593 GCCGGACGGUCGCCCGGAGGCCCCCGUAUCCCCACGGUCCCCCCACGAGCCCUCACCCCCU CCCCGCGGGCGCCAGGCCGCGGACCACCCGCACCAUGGAGCGGGUGGGCAGGAACCCGCCC 594 GCCGGACGCUCGCCCGUAGGCCCCCGUAUACCCACGGCCCCCCCACGAGCCCUCCCCCCCU CCCUGCGGGCCCCCGGCCGCGGACCACCCCCAACUUGGACCGGGUGGGUAGGAACCCCGCC 595 CCCGGACGGUCGCCCGGAGGCCCCCGUAUCCCCACGGCCCCCCCACGAGCCCUCACCCCCU CCCCGCGGGCGCCAUGCCGCGGACCACCCGCAACAUGGAGCGGGUGGGUGGAAAUCCCGCC 596 CCCCGACGGGCGCCCGUAGUCCCCCGUAUACCCACGGCCCCCCCACGAGCGCUCACCCCCU CCCCGCGGGCCCCAGGCCGCGGACCACCCCCACCAUGGAGCGGGUGGGCGGGAACCCGCCC 597 GCCGGACGGUCGCUCGUAGUCCCCCGUAUACCCACGGCCCCCCCACGAGCCCUCACCCCCU CCCCGCGGGCGCCCGGCCGCGGACCACCGGCACCAUGGACCGGGUGGGCGGGAAGCCGCCC 598 CACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGGAUCCACAAGGGUCUACGCUGGCG UUCUGACGUUGGAAUUAUGUAGAUGAAAGUUAGCGAGGAGCUUUUAACUGGAAAUGUGGAC 599 AACAUCCUCUCGAUCCGACCGCAGCAUGUUACCUAGGAAGCCACUGGGGUGCACGCGGCCU UACUGACGUUCGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAACUGGAAAUGAGAAC 600 AACAUCCUUUCGAUCGGAGCGCAACGUGUUACCCAGGAACCCACUUGCGUGUACGCGGCCG UACUAACGUUCGAAUUCUGUAGAUGAAAGUCGGCGAGGAGCUGUUCAUUGGAAAUGAGAAC 601 AACAUACUCUCGAUCGGAUCGCCACGUGUUACCAAGCCAUCCACUUGGGUGCACGCGGGCG UUCUGACGUUGGAAUUCUGUAUAUGAAAGUUAGCUAGGAGCCUUUAACUGGAUAGGAGAAC 602 AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGGGGCCG UUCUGACGUUGGAAUUCUGUAGAUUACAGUUAGCUAGGAGCUUUUAAUUGGAGAUGAGAAC 603 AAGACCCUUUCGGUCGGAUUGCUAGGUGUUACCAACGCGUCCACGAGGGCGUACGCGGCCG UUCUGACGUUGGCGUUAUGUAGAUGAAAGAUUGCUCGGAGCCUUUAAAUGGAAAUGAGGCC 604 GACAUACUCUCGGUCGGAUCGCGGGGUGUUACCAACCCAUCCACUCGGGUGCACGCGGGCG UUCUGACGUUGGCGUUCUGUAUAUGAAAUUUAGCUAGGAGCCUCGAGCUGGAUAGGAGAAC 605 ACUAUCCUGUCGAGCGGAUCGCUGCUUAUUGCCCGGGCAUCCCCAUGGGGGUACGCGGCCG UUCUGACGUUCUAAUUCUGUAGAUUACAGUAGGCUAGGAGCUUUUAAUUGGUGAUGAGGCC 606 CAGAUACGCGCGCUCGGAUCGCAACGUGUUACCCCGGACUCCACUGGGGGGCACGCGGCCG607UACUGACGUUGCCAGAAUGUAGAUGAUAGUUGGCUCGGAGCUUCUCAUUGGGAACGAGAACAttorney Docket No.: 62801.85WO01AAUAUCCAAGCGGUCGAAUCGCGUCGUGUUGCCGAGGAAACCGCUCGGGUGCACGGGGCCG UUCUGACGUUGGAAUGCUGGAGAUUACAGUGAGCUGGGAGCUUGUGAUUGGAUAUGAGAAC 608 AAGAGCCUAGCGGUCGGACUGCUAUGUGCUACCAACGCGUCCAGGAGCGUGUACGCUGUCG UUCUGACGUUGUCGCUCUCUAUAAGAAAGAUUGCUGGGAGCUUGUCGGUGGCAAUGAGAUC 609 CAAAUGGGCUCGCUCGGAUUCCUAAUUAAUACCCGGGGCUCCGGUAGCGUCCACGAUGGCG UUCUGACGUUGUUAUUGUCUAGAUGAAAGUUAGCGGGGAGCUGUUAGCUGGAAAUGCGGAC 610 ACUAUCCCCUCUGUGGGACCGCAGCAUGAUACCCGGGCAUCCAUUGGGGUGCACGCAGCCU CACUCACCUUUGAGUGACGUAUAUGAUAGUUAGCUGGGAGCGUAUAAGUGGCGAUGAUCAC 611 AAAAUACGUUCGAUUGGAGCCCUGUAUGAUACCUGCGGCUCCUCUUGGGUGUACGAGGCCG UUCUGACGGUGUAAUGUAAUAGAUGUAAGCCAACGGGGAGCCUUUAAAUGGAAAUGAGCAC 612 UCAAUACUGUCGAGCGGAUCGGUGGUUAAUGCCUGAGCAGCCCCAGGGGUGUGCGAGGCCG UACUGACGUUUUAAUUGUGUAGAUCACAGUUAGCGAGGAGCCAUUAAUUGGUGAUGAGAUC 613 AAUGCCCCAUCUGUGACCUAGCAGCGUAGCCUUUGGGCGUUCUCGCACGCCCUCCUCCCCU UCCUGCCCCCGGUCCCCAGUGGCAUUCGAAUUAAGACUGAGUAGGCGUC 614 AUCAGUGACUCCCUAGCCGAGCAACGAGACCCUUGGGCGUACCCCCACGACCUCCUCCCCG ACCUGCCCCCGUACCCCGAUGGCAUUGGAAUUAAGUCCGACUUUGCUGC 615 GCUGUAGUCUCGGUGGCACAGCUUAUUGUCCCCAGUGCCUCCCCCCAACCCCUCCUCCCCU CCCUGCACCCGUCCGCCCGUGGUCGUUGGAUUAAGUCCGAGCGGGCGGU 616 GCCGUAGUGUCGGUGGCACUGCUUAUUGUCUCCAGGGCCUCCCCCCAACCCCUCGUCCCCU CCCUGCAGCCGUCCCGCCGUGGACUUUGGAUAAAGUCCAAGUGGUCGGC 617 GCCGUAGCCUCGCUGGGACCGCAUGGUAUCCCCAGGGCCUCCCCCCGACCCCUCCCCCCCU CCCUGCCGCCGUACGCCCGUGGACUUUGAAUAACUUCGAGCUGGGCGGC 618 GCCGUAGCCUCGCUGGCCCCGCUUGGUAUCCCCAGGGCCUCCCCCCAACCCCUCCCCCCCU UCCUGACGCCGUCCGCCCGUGGACCUUGACUAACUUGGAAGCGGGCGGC 619 GCCGUAGCCUCGGUGGGACCGCUUCGUAUCCCCAGGGUCUCCCCCCAACCCCUCCCCCCCU CCCUGUCCCCGUACGCCCGUGGACUAUGAAUAACUUGGAAGUGGUGGGC 620 GCCGUAGCCUCGGUGGGCGAGCAUCGUAUCCCCUGGGCCUCCCCCCGAGCCCUCCCCCCCU UCCUGCAGGCGUCCCCCCGUGGACCUUGACUAACGUGGAACUGGUCGGC 621 AAUGCAGCCUCGGUGGCCUAGCUUCUUGUCCCUUGUGCCUCCCCCCAACCGCUCGUCCCCC UCCGGCACCCGGACCCCCGUGGCAUUCGAAUAAAGUCUGAGAGGGCGGC 622 ACUUGAGCCUCUGUGGCCUAGCCGCGUGACCCUUGGGCCUCCCCCCAACCCCACCUCCCCU UCCUGCACCGGGACCCCCGUGGCCUUUGAAUAAAGACUGAGUUGGCCGC 623 AAUGCAGCAUCGGUGACAUAGCUUCUUGUCCCUUGGGCCUCCCCCCAACCGCUCGUCCCCC UCCGGCACCCGGUCCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCCGC 624 AAUUGAGCCUCGGUGGCCUAGCUUCUUGUCCCUUGUGCCUCCCCCCAACCCGCCCUCCCCU UUCCGCACCGGUACCCCCGUGGUCUUUGAAUAAAGACUGAGUUGGCCGC 625 GCUGUAGUGUCGGCGGUAUCGCUUAGUGUCCCCAGUAACUCCCCCUAACCCCUCCCCCCCU CCCUGCCGCCGUCCGGCCGUGGACGUUGGAUAAAUUCCAAGUGGUGGGC 626 UCUGGAGUCUCGGUGGCCUAGCUUCUUGUCCCUUGGGCCUCCCCCCAACCCCACCUCCCCC UACGGCACCCGGUCCCCCGUGGCCUUUGAAUUAGGUCGGAGUAGGCGGC 627 GCUGGAGUCUCGGUGGCCUAGCUUAUUGUCCCUUGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCACCCGUACCGCCGUGGUCUUUGAAUAAAGUCCGAGUGGGCGGC 628 GCUGGAGUCUCGGUGGCCUAGCUUCUUGUCUCUAGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCCCCCGUACCCCCGUGGACUUUGAAUAAAUUCCGAGUGGGCGGC 629 GCUGGAGUGUCGGUGGCCUCGCUUCUUGUCCCCAGGGCCUCCCCCCAACCCCUCCUCCCCU CCCUGCAGCCGUACCGCCGUGGUCUUUGAAUAAAGUCCGAGUGGGCGGC 630 GCUGGAGUCUCGGUGGCAUAGCUUCUUGUCCCCAGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCCAAGUGGGCGGC 631 GCUGGAGUCUCGGUGGCACAGCUUCUUGUCUCUUGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCCGAGCGGGCGGC 632 GCUGGAGCCUCGGUGGCCCAGCUUCGUGUCCCCAGGGCCUCCCCCCGAGCCCUCCUCCCCU UCCUGCAGCCGUACCCCCGUGGACUUUGAAUAAAGUCGAAGUGGGCGGC 633 GCUGGAGCCUCGGUGGCACAGCUUCUUAUCCCCAGGGCCUCCCCCCGACCCCUCCCCCCCU634UCCUGCAGCCGUACCCCCGUGGUCUUUGAAUAACGUCGAAGUGGUCGGCAttorney Docket No.: 62801.85WO01GCCGUAGCCUCGGUGGCACAGCUUCUUAUCCCCAGGGCCUCCCCCCGACUCCUCCUCCCCU UCCUGCAGCCGUACCCCCGUGGUCUUUGAAUAACGUCGGGGUGGGCGGC 635 GCCGGAGCCUCGGUGGCCCAGCUUAGUAUCCCCAGGGCCUCCCCCCAACCCCUCCCCCCCU UCCUGCAGCCGUACCCCCGUGGACGUUGAAUAACGUCGGAGUGGGCGGC 636 GCUGUAGUGUCGGCGGCACCGCUUAGUAUCUCCAGUACCUCCCCCCAAACCCUCGCCCCCU CCCUGCCGCCGUCCCGCCGUGGACGUUGGAUUAAAUCCGAGCGGUCGGC 637 GCUGGAGCCUCGGUGGCCCAGCUUCGUAUCCCCUGGGUCUCCCCCCAAGCCCUCCUCCCCU ACCUGCCCCCGUCCGCCCGUGGUCCUUGAAUAAAGUCGAAGUGGGCGGC 638 GCCGUAGCCUCGGUGGGCGAGCUUCGUAUCCCCUGGGCCUCCCCCCAACCCCUCCCCCCCU UCCUGCACCCGUACCCCCGUGGACUUUGAAUAAAUUGGAAGUGGGCGGC 639 GCCGGAGCCUCGGUGGGAGAGCUUCGUGUCCCCUGGGCCUCCCCCCAACCCCUCCCCCCCU UCCUGCAGCCGUACCCCCGUGGUCUUUGACUAAAUUCGAAGUGGGCGGC 640 GCUGGAGCCUCGGUGGGACAGCAUCGUAUCCCCUGGGCCUCCCCCCAACCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGACUUUGAAUAAAUUGGAAGUGGGCGGC 641 GCCGGAGCCUCGGUGGCAGAGCUUCGUGUCCCCUGGGCCUCCCCCCAACCGCUCCCCCCCU UCCUGCAGCCGUACCCCCGUGGACUUUGACUAAAGUGGGAGUGGGCGGC 642 GCCGUAGCCUCGGUGGCCCCGCUUCGUAUCCCUAGGGCCUCCCCCCGACCCCUCCCCCCCU UCCUGCCCCCGUACCCCCGUGGACUUUGAAUAAAUUGGAAGUGGGCGGC 643 AACCUAUGUCCAUGUCCCCGCUGUGAUAUAUACACCACCCCUUUCUUUCGGGUGAGCCGCC GUGCCGUCAUCGAACUGCACGAGCUUCCCACGACGGUAAAUCUUCCGAUCGAAAGCUCGCC CCGGCGCUCACCCUCCUUCGGGAACGCCCCCCGCCAAGCAGCGGGGGCUUUGCACGGCCCU 644 CAAUGAUUUUGC AUCAUUUGCCAACACCUCCAUGGAGUAAUAGACACCACCCCGCUCGCUCGGGUGAGCACCC AAGCCCCGCACCUACUGCACUAGUUUGCCAGGACUAUGGUUCCUAAGAGCGUACCCUCACC GUGGUGCCGCCCUGCCUCCGGCAACUCCUCUCGAAGGGCCGGACCGCUUUCGCACCUAAAU 645 AACUGUUCUUCC ACCCUAUGGGCACCGCUACAUCUAGGUAUAACGAGUACCCCCCUCUACACGGUGAGCCCCU ACCCCACGGUGGCACGCCAUUCACGUCCGAAUACUUUCCGUCGGUGGGUAGCAACCGGACC UUGGUACCGCGCUUGCUUCGGGAGCUGCACCCUCGGAGCAGGGCCGUCAUCGAACUUUUCU 646 ACCUGUUCUUAC GCCCUAUUCGCACCGCUACCGCGAGGUAUAUCGAGCAACCACCUCUGUCGGGUGAGCCCCC ACUCCACGGCGGUAGGCACUUAACCUCCGAAUACUUUCCAUCGGUGGGUCGCAAUCGCGCC UUGGUGCCCCGCCCCCAUCGGGAACUGCAACCGCGGACCAAGGCCGUCUUUGCACUUAUCU 647 AGCUGUUCUUAC GCCGUAGUCUCGCUGGGACCGCCUAGUGUCCCCACGGUCUCCCCCCGAGUCCUCCCCCCCU CCCUGACGCCGUCCGCCCGUGGACCUCGACUAACUUGGAACUGGUCGGC 648 ACCAUAGGCGCACUCGUACCUGACGGUAUAACCACCAACCCCCUCAGUGUGGUGACGCCCU ACCCCACGGUGGCAGUCCGCAGACCUCCGUAUCCUUGGAGCCUUUGGGUCGCAAUCGCACC UUGGUAGCGCGCUUGCUUAGGGAGCUGCACCCGCGGACCAGGGCCGUCUUUGCACUUUUCU 649 AACUGUUCUUAC ACCAUAGGCCCACCCCUACGUCAUGGUAUAACCACCAUCCCCCCCUGUGUGGUGGGCCCCU ACCUCAGGGUGGCAGGCCGCAGACGACCGCAUCCUUGGAGUCUUUGGGUCGCAAUCGCACC UUGGUGCCCCGCCUCCUCCGGGCCCUGCACCCGCGGACCAGGGCCGUCUUCGAACUUUUCU 650 AACUGUUCUUAC ACCAUAAUCGCGCUCGGAGCCCAUGGUAUAACCACCAUCCACCUCCGUGUGGUGACCCCCU ACCCCACGGUGGUAGUGCGCAGACGACCGCGACCUGGCAGUCAUUGGAUCGCAAUCUCACC CUGGCAGCGCCCCACCUCAGGGACCUGCACCCGCGGACCAGGGCCGGCUUUGAACUUUUCU 651 ACCUGUUCUUAC ACCAUAUGCUCGCUCGGACGCCGUGGUAUAACCACCAUCCACCUCCGUGUGGUGACCCCCU ACCUGUCGGCGGUAUGGCACAGACGACCCCAACCUGGGAGUCAUUGGAUCGCAACCUCACC CUGGAAGCGCGCCUCCUUCGGGACCUGCACCCGCGGACCAGGUGCGUCUUGGAACUCUUCU 652 ACCUGUUCUUAC ACCAUUUGCCCACUCCGCCACUGUGAUAAAAACACCACGCACUUCAUUCGGUUGUGCCCGG CGGACGUCGUUGUACAGCACUUCCUUCCGAAGACGGUCCUUUUUUGGAUUGCGGUCUCUCG CUGGUGCGGCGCUUCCUGCGGGAACUUCACUCACGGACCAGGGCGGUCUUUGAACUGUUCU 653AACUGUUCCUUCAttorney Docket No.: 62801.85WO01AUCACUUGCCCAAUCCUCCAUCCUGUUAUAAACACCACGGACCUUGUUCGGGCGAGCACCU AGGCCCCGCAUCUACUGCACUAGCUUCCCAGGACGAUCCUUUGUCUGAUCGCUGUCUCACC CCGCCGCCGCGCUUCCUUCGGGAACCGAACCCGCUGUCCAGGACCGUCUCGGAACUUUUCU 654 AACACGUCUUCC GCCCUAUGGGCACCGCUACCUCGUGGUAUAAAGAGCAACCACCUCCAUCGGGUGAGCCCCU ACGCCAUGGUGGCAGUCCACAAUCGUCCUAAUACUGUCCGUCGUCGGGUAGCAAUCUCACC UUGGUGCCGCGCUUCCACCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 655 AACUGUUCUUAC GCCCUAUGGGCACCCCUACCGCGUGGUAUAAAGACCACCCCCCUCUUUCGGGUGAGCCCCU ACGCCACGGCGGUCGGCCCCACACAUCCUAAGACUUACCGUCGUUGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGCACUGCAACCGCGGACCAGGGCCGUCUUUGAACUUUUCU 656 AACUGUUCUUAC ACCCUAGGCGCACUCCGACCUCACGGUAUAACCACCACCCACCUCUGUGGGGUGAGCCCCU ACCCCAUGGUGGUAGGCCACAAACCUCCGAAUACUGUGCUUCUUUGGAUCGCAAUCUCACC CUGGCACCGCGCAUCCUUCGGGACCUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 657 AACUGUUCUUAC ACCCUACGCGCACCCCGACCUCCUGGUAUAACCACCACCCACCUCUGUGGGGUGAGCCCCU ACCCCAUGGUGGUAGUCCACAAACCUCCGAAUACUGUGCGUCUUUGGGUCGCAACCUCACC CUGGCGCCGCGCUUCCUUCGGGACCUGCACCCUCGGACCAGGGCCGUCUUUGAACUUUUCU 658 AACUGUUCUUAC ACCGUAGUCUCGCUGGGACCGCACAGUGUCCCCAGGGUCUCCCCCAGACCCCUCCCCCCCU CCCUGAGGCCGUACGCCCGUGGACCUCGACUACCUUGGAACUGGUGGGC 659 ACCCUACGCUCACUCCGACAUCGUGGUAUAACCACCACCCACCUCCGUGGGGUGAGCCCCU ACCCCACGGUGGUAGUCCGCAAACCUCCGCGACCUGUGCGUCUUUGGAUCGCAAUCGCACC CUGGUGCCCCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 660 AACUGUUCUUAC ACCCUACGCUCACUCCGACAUCGUGGUAUAACCACCACCCACCUCCGUGGGGUGAGCCCCU ACCCCAGGGUGGUAGUCCGCGAACGUCCCCAUACUGUGCGUCAUUGGAUCGCAAUCUCACC CUGGUGGCGCGCUUCCUUCGGGACCUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 661 AACUGUUCUUAC AUCAUUUGCCCAUUCCUCCAUGGUGAUAUAAAGACCACCCACGUCCUUCGGGUGAACCCGU CGGCCACGGUUGUACUGCACUACCUUCCGACGACGGUCCUUCUUCUGUUCGCAAUCUCAGC CUGGGGCCGCGCUUCCUUCGGGAACCGCACCCGCGGACCAGGGCAGUCUUUGAACUUUUCU 662 AACAGUUCUUUC AACCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACGUCCUUCGGACGAGCCACU AAGCGAAGGUUGUCCAGCACUAACAUCCCAAGACGGUCGUUUUUCCGAUCGCAAUCUCACC CUGUUGCCUCGCUUCCUUCGGGAACUGAACCCGCGGAACAGGGCGGUCUUUGAACUUUUCU 663 AACUGUUCUUAC AACCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACGUCCUUCGGGCGGGCCCCU AACCCACGGUUGUCCUGCACUACCUUCCUACGACGGUCCUUCUUCCGAUCGCAAGCUCGUC CUAGUGCCGCGCUUCCUUCGGGAACCGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 664 AACAGUUCUUUC AACCUUUGCCCACUCCUCCAUGGAGAUAUUAAGACCGCCCACGUCCUUCGGUUGAGCCCCG ACGCCAUCGUUGUCCUGCACUACCUUCCUAAGACGUUCCUUCGUCCGAUCGCGAUCUCACC CUGGUUCCGCGCUUCCUUCGGGAACCGCACGCGCGGACCAGGGCCGUCUUUGAACUUUUCC 665 AACUGUUCUUAC AACCUAUGCCCACUCCUCCACGGUGAUAUAAAGACCACUGACCUCUUUCGGGUGUGCCCCU GAGCCACGGUUGUCCAGCACUAACUUCCCAAGAUGGUCCUUCUUCCGAUCGCAAUCUCACC CUAGUGCCGCGCUUCCUUCGGGAACUGCACCAGCGGACCAGGGGCGUCUUUGAACUUUUCU 666 AACUGGUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCCCCUCCUUCGGGUGAGCCCCU AAUCCAUGGUGGUACGGCACUAUCGUCCUAAUACGGUCCGUCUGUGGAUCGCAAUCUCACC CUGGUGCCCCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 667 AACUGUUCUUAC ACCCUUUGCCCACCCCUCCAUGGAGGUAUAAAGACCACCCACCUCUUUCGGGUGAGCCCCU AAGCCAUGGUUGUAGUGCACUAACGUCCUAAUACGGUCCUUCUUUGGGUCGCAAUCUCACC 668Attorney Docket No.: 62801.85WO01CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU AACUGUUCUUAC ACCCUAUGGCCACCCCUCCAUGGUGGUAUAAAGACCACCCACCUCCAUAGGGUGAGCCCCU ACCCCAUGGUUGUAGGGCACUCACAUCCUAAGACUGUCCUUCGUUGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 669 AACUGUUCUUAC GCCGUAGCCUCGGUGGGAGUGCAUGGUAUCCCCACGGCCUCCCCCCGAGUCCUCCCCCCCU CCCUGUCGGCGGCCGCCCGUGGACGAUGGAUAACUUGGAACUGGUCGGC 670 ACCCUAUGCGCACUCCUCCAUGGUGAUAUAAAGACCACCCACCUCCGUCGGGUGAGCCCCU ACGCCAUGCUUGUAGGGCACUAACAUCCUAAGACGGUCCUUCGUUGGAUCGCAAUCGCACC CUGGUGCCGCGCUUCCUUCGGGAGCUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 671 AACUGUUCUUAC ACCCUUUGGCCACUCCUACAUGGUAAUAUAAAGACCAACCACCUCCUUCGGGUGAGCCCCU ACGCCAUGGUUGUCGUCCACUCUCAUCCUAAGACGGUCCUUCGUUGGAUCGCAAUCUCACC CUGGUGCCCCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 672 AACUGUUCUUAC ACCCUAUGCCCACUCCUCCCUCGUGGUAUAACGACCACCCCCUUCCGUGGGGUGAGCCCCU ACCCCAUGGUGGUACGGCACUAACAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 673 AACUGUUCUUAC ACCCUAUGCCCACUCCUACCUGGUGGUAUAACGACCACCCACCUCCUUCGGGUGAGCCCCU AAGCCAGGGUGGCAGUGCACAAACAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGACCUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 674 AACUGUUCUUAC ACCCUAUGCCCACUCCUCCCUGGUGGUAUAACGACCACCCACUUCCUUGGGGUGAGCCCCU AACCCAUGGUGGUAGUGCACUAUCGUCCUAAGACGGUGAUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 675 AACUGUUCUUAC ACCCUUUGCCCGCUCCUACUUGGUGAUAUAACGACCAUCCCCUUCCGUCGGGUGAGCCCCU ACCCCAUGGUGGUACUGCACUAACAUCCUACGACGGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 676 AACUGUUCUUAC ACCCUUUGCCCACUCCUACCUGGUGAUAUAACGACCACCCCCUUCUGUCGGGUGAGCCCCU ACCCCAUGGUGGUACUGCACUAACCUCCUAAGACUGUCCUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGACCUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 677 AACUGUUCUUAC ACCCUAUGCCCACUCCUCCAUGGUGGUAUAAAGACCACCCACUUCCGUCGGGUGAGCCCCU ACCCCACGGUUGUAGUGCACUAACCUCCUAAGACUGUGAUUCUUUGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 678 AACUGUUCUUAC ACCCUAUGCGCACUCCUACAUGAUGAUAUAACGACCACCCACUUCCGUCGGGUGAGCCCCU AAGCCAUGGUGGUACUGCACAAACAUCCUCAGACUGUCCGUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 679 AACUGUUCUUAC ACCCUAUGCUCGCUCCUACAUGGUGAUAUAACGACCACCCACCUCCGUCGGGUGAGCCCCU ACCCCAUGGUGGUAGUGCACUAUCAUCCGCAGACGGUCAUUCUUCGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 680 AACUGUUCUUAC GCCGUAGCCUCGGUGGGACCGCCUAGUAUCCCCACGGCCUCCCCCUGAGCCCUCCCCCCCU ACCUGACGGCGUCCGCCCGUGGACCAUGCAUAACUUGGAGUUGGUCGGC 681 ACCCUAUGCUCACCCCUCCAUGGUGAUAUAAAGACCACCCACUUCCGUCGGGUGAGCCCCU AACCCAUGGUGGUAGUGCACGAACGUCCUGAGACGGUCCCUCUUUGGAUCGCAAUCUCACC CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU 682 AACUGUUCUUAC ACCCUAUGCUCACUCCUACAUGGUGAUAUAAAGACCACCCACUUCCGUCGGGUGAGCCCCU683ACGCCACGGUGGUACUGCACAAACCUCCUAAGACUGUCCGUCUUUGGAUCGCAAUCUCACCAttorney Docket No.: 62801.85WO01CUGGUGCCGCGCUUCCAUCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCU AACUGUUCUUCC GCUGGAGCCUCGGUGGCCUAGCUUCUUGUCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 684 ACCAUCCUCUCGAUCGGCUAGCAUCGUGUUACCCAGGCCUCCACCCGGCUGUUCGCCCCCU UUCUGACGUUGGAACUCCGUAGUCGUAAGAUAACGAGGAGCUUUUAGUUGGAAAUGAGAAC 685 AACAUCCUCUCGAUCGGCUCGCAACGUGUUACCCAGGACUCCACUUGGGUGUACGCGCCCG UUCUGACGUUGGAACUCCGUAGACGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 686 AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGACUCCACUUGGGUGUACGCGCCCG UUCUGACGUUGGAAUUCCGUAGUCGAAAGAUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 687 AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGCCUCCACUUGGGUGCACGCGCCCG UCCUGACGUUGGAAUUCCGUAGACGUAAGAUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 688 ACCAUCCUCUCGAUCGGCUCGCAUCGUGUUACCCAGGCCUCCACCCGGGUGCUCGCCCCCU UCCUGACGUUGGAACUCCGUAGUCGUAAGAUAACGAGGAGCUUUUAGUUGGAAAUGAGAAC 689 GAAGCACCCUCUGUGACCUAGCCGCGUGACCCUUGGGCCUCACCGCACGCCCACCUCCCCG UCCUGCCCCCGGACCCCCGUGGCAUUGGAAUUAAGACUGAGUAGGCCGC 690 ACCGUAGCCUCGGUCGCCUCGCUUCGUGUCACCUAGGCCUCCCCCCGGCUGCUCCUCCCCU UCCUGAAGCUGGAACUCCGUGGUCUUUGAAUAACGUCGGAGUUUUCGGUGAAUAC 691 GCCGUAGCCUCGGUCGCCUAGCUUCGUGUCCCUUGGGCCUCCCCCCGGCCGCUCCUCCCCU UCCUGCACCUGGACCUCCGUGGUCUUUGAAUAACGUCUGAGUGGUCGGU 692 ACUUCAGCCUCGGUGACAAAGCCGCGUGACCCUUGGGCCUACCCCGUACGCCUCCACCACU UCCUGCCCCGGUUCCCCGGUGGCAUUUGAAUUAAGACUGAGAAUGCCGC 693 CCCAAGCUUUAGUCUUACUUAGACAGAGUUGCCCAGGAAUCGACUUUGGGGUGCCACCCGC CGCAGAGGUCGGCAUUCCGUAGAUGAAAGUUAGCUCGGUGCACACAUGAGCACUUCGCCUA 694 AGAAGUGUCUAGGUGGGACGGAGAGUUGUUACCCAAUAAUCCCUUUGGGUGUAGCCCAGCG CUGAGGCGUAGGUACCGAAUCACCGCCUUUAAACGAGCACCGCGCAAUUAGACCACUGCCC 695 UCCAUCUUGCAGAGUGUUUAGAAACGAGUUCGCCAGGAAUCCACUUGGGUGUACGCGGCCA AACUGACGCGGGAAUUCGGUAGAUGAAAGUUAACUACGGGCUCAUCACUGCGCUUGGCCCC 696 CUGAAGCAUACGGGGUCUUAGGAGAGAGUUCCCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUAAGCACUUAUCAGUGCGACCGCGACC 697 ACCAUUCUAUAGAGUCGGUCGAAAAGAGUUAGACAGGAAUCCACUUGGGUGUCCGCGGCCG UUCUGACGCGGGAAUUCCGGAGGAGAAAUUCAGGUAAGCACUCAUAAUUGGGCACGUGACC 698 CUGAAGCAUACGGGGUAUUAGGAGAGAGUUCCCCAGGAAUCCACUUGGGUGUCCGCGGCCG UUCUGACGCGGGAAUUCUGUAGAUGAAAGUUAGCUAAGCACUAAUCAUUGCAAACGACCCC 699 ACCAUUCUAUAGAGUCGGUCGAAAAGAGUUAGACAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGCCGGAGUUCCGUAGUUGAAACUCCGGUAAGCACUCAUAAUUGGGGACGCGACC 700 AAUAUCCAAGCGGUGAGUUCGCAAGUUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUAUGAUCUCAUAAUUGGCAAUUACCCC 701 AGCAGCCUUUAGGGUGACUUGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUCGGAGCUAUCAAUACGAUACGCGACC 702 AGCAGCAUAUCGAUCGGUUCGGAAAGAGUUCCCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUCCGCGCUUUUAAUUGGCCCCGCGACC 703 ACCAUCUUCACGAUGAGUUAGAGAGUUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUUAGCUAUGACCUCGUACUUGGCACUCAGCCC 704 AGCAUCUUCACGAUGAGUUAGAGAGUUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUUAGCUAUGAACUCAUAAUUGGCACUCAGCCC 705 UCCAAGCGGGUGGUGUAUUAGGAGAGAGUUCCCCAGGAAUCCUCUAAGCACUAAGGCGCCG GUCCGCUGCGAGCUUUAGAAAGACGCCGGUCAAUCGUGGCCUUUGCCCUGCGAACCCGACC 706 AAUUUCAUAUCGAUCGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAA 707 GGCAGAGUCUGGGUGGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUCUGACC 708 AGCAACCUCUGGGUGGGAUAGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG709UUCUGACGUGGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAAUUGGCAAUGAGUCCAttorney Docket No.: 62801.85WO01AGCAACCUCUGGGUGGGAUAGAAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUCAUCAUUGGAAAUCAGAUC 710 AGCAGCCUCUGGGUGGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGCGGGAAUUCUGUAGAUGAAAGUUAGCUAUGAGCUUUUAAUUGGUAAUCAGCCC 711 AACAUCCUCUGAAUCAGCGCUAAACGUGUUACACAGCACCGCUUUUGGGUGUACGCCGACG GACCGACGUCGGACUUCAGAAGAUGGCAGUGGUUUGGGACCUGUUUAAUGUCCGUUAGAAC 712 UCUCAAAA AACAUCCGCGAGAAAGCAUCGCUACGAGUCACUGAGGACGUCACUUGGGUGUACUUGGUCG UACCCACCAGGGCAUUCUGACGAUGAAAGUCAGCCAGGCGAUUUUCAUUGUACUUGCGAAC 713 UCCAUCAA AAGAUCCCCUUGAACGGACCCCUACGAGUUACACAGGACGCCACUUGGGUGUACACGGACG GACCGACGUCGGACUUCAGAAGAUGGGCGUGAGUUCGGAGAUUUUCAUUGGACUUGCGAAC 714 UCGCAAAA AACAUCCUCUCAAUCGGCCCUCAACGUGUCACACAGGACGCCACUUGGGUGUACGCGGACG GUCCGACGUUGGGAUUCUAUAGAAGAGAGUCAGCCCGAAGUUUUCAAUUGUAAAUGAGAAC 715 CCUAAAAA AACAUCCUCUCAAUCGGCCCUCAACGAGUCACAGAGCAACACACAUGGGCGUACGUGGUCG UUCUGACGAGGGAAUGCUGUAGCUGAAAGUUUGCCGGGGGAUUUUAAUUGGGAAUGAGAAC 716 UAACAAAC CCCAAGCUAUAUAGUAUAUAGAGAGUCGUUAGCAAUCAUUUUACCAUGAUAAACCACUACG AAGUGCCCUCGGUGUUCGGAAGAGGAUAGUCAGCUAAGCACUUACCAUGGGGGCGGACCUA 717 AACAUAUCCUCGUUAGGAGCGCAACGUGUCACCGAGGACGGCACUUGGGUGUACGUGGACG UCCUGACGCGGGAAUUCUUUCGGAGAACGUUCGCUAGGGGCUUUCCAUUGGAAAUGAGAAC 718 UAUAAACU AACAUCCUCUCAAUCGGCGCGCAACGUGGUACACAGGAAGCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGCUGAAAGUCAGCUAGGAGUUUUUAAUUGGACGUGAGAAC 719 GAAAACAA AACAUCCUCUCAAUCGGAGCGCUACGUAUAACUCAGGAAGCCACUUGGGUGUACGCGGUCG UUCUGACGAGGGAAUUCUGUAGAAGAAAGUUGGCUAGGCGAUUUUAAUUGUACAUGAGAAC 720 AAAAAAAA AACAUCCUCUCUAUCGCACCGCAACGUGUUACACAGGACCACACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGCUGAAAGUUAGCUAGGAGAUUUUAAUUGUACAUGCGAAC 721 AAAAAAAA AACAUCCCCACCAAUGGCUCUAAACCAGUUACCAAGCAACGCACUGGGGUGUACGCGGCCG UUCUGACGGUGGCCUUAUGAGGAGAAGAAUUCGGUCCGAGAUUGUAUUUUCUUGUAAGAAC 722 AAUAUCCUCUGAACGGGCACGACACGAAGUACACGGGACGCCACUGGGGUGUACGCGGUCG UUCCGACAACGGCAUGCUAUAGCAGGAAGUCCGCCAGGAAAUUUUUAUUGUAAAAGCCACC 723 AACAUCCUCUCAAUCAGCCACCAACGAGUCAGCAAGGCAUCGAGUUGAGUGUACGCGGCCA CACUAACGACGUGAUUCUGGUGUAGCAGGUCAGCCCGAAGAUUUUAAUUGCCGAUGCGCAC 724 AACAUCCGCUCGAUCGGAGCCCUACGUGUUACACAGGACGCCACUGGGGUGUACGCGGCCG UUCCGACGACGGCAUGCUAUAGCAGAAAGUCGGCCAGGAAAUUUUAAUUUCUAAUGAGUGC 725 AACAUCCUCUCAAUGGGCCCUCAACAUGUUACACAGCACCCCGCUUGGGUGUACGCGGCCG UUCCGACGUUGGGAUUCUAUCGAUGAAAGUCUGCCAGGCGAUUUUAAUUGUACAUGCGAAC 726 AACAUCCGCCUGAUCGGAGCGCUACGUGUCACACAGGACCGAACUUGGGUGUACGGCGCCG UUCUGACCAUGGCAUUCUGGAGAAGAAAGUCAGCCCGAAGUUUUUAAUUGUACUUGAGAAC 727 CCCAAGGUUUAGUGUGACUUAGACAGAGUUCCCCAGGAAUCGACUUUGGGGUUGCACGCCG UUCAGACGUCGGCCUUCCGUAGAUGAAAGUUAGCUCGGUGCACACAUGAGCACUUCGCCUA 728 AACAUCCUCUCAAUCGGCUCUAAACGAGUUACAAAGGACCGCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUAAAAGUUGGCUAGGAGAUUUUAAUUGGACAUGAGAAC 729 AACAUCCUCUCAAUCAGCUCGAAACGUGUUACACAGGAACCCACUUGGGUGUACGGGGCCG UUCUGACGAUGGAAUUCUGUAGCUGAAAGUCAGCUAGGAGAUUUUAAUUGUACAUGGGAAC 730 AACAUCCUCUCGAUCGGCUCUAAACGUGUAACACAGCAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGCUGAAAGUCAGCCAGGAGAUUUUAAUUUUAAAUGAGAAC 731 ACCCUUUGCCCGAUCGUACAGCAACGUAUUACCAAGACCCCCUCCCUGGUGUACACGGCCU UUCUCACGGUUGAAUUCUGUAGAUGACAUAUGGCGGGCAUCUUUUGAAUGGCAAUGAGAAC 732AUGAAAACGUCCGGAUGCCCGCCGGCCGAAUUCUUCUAttorney Docket No.: 62801.85WO01ACCCUUCUCUCGAUCGGCCCUGUUAGUAGAAAGCACACACCCACCUUUCAGUAGACCCCCG UUGCAAUGUUGUUAUAACAUUAACCUACUUUAGCUGGGCUCCCUCAUUUGGGAAUGUGAAC 733 GUAAACAACUCUCGAGCACCCGCUGUACAUACCUCUGUCUCCGCGCAGGAC AACCUGGUCCCGCUCGGAUAGCAAGAUGUUACGCCGGACUCCUCCCAGUUGCACACGGCCG CUCUGACCUUUGACUUCCGUAGUUGAAAAUUAACGAGUAACCUCUGAGUUAAAUCGUACUU 734 AAAGCGAUCCGCCACUCCUAGUUCU GCCCUUGUGGCACUCCGCCAGCAACGCACUCCUUACGAAUACCCUCGGGGGUACCUCGCCG UUCUGACGUUGGACUUCUGUAGUUGAUAGUUAGCGUGGCGCCAUUGAGUGGAAUACAAGCG 735 GUGGAUACCGCUUCCGCC GACAUCGAUUCAAUGAGCUCUGAUGAUGCCUCCCAGGAAUCCACCCUGGUGGAGCUGGCCG UACUGCACUUGUUAUCCUGCACACUAUACUUAGCUCGGAUGUGGUGAUUGGGACACCGGGC 736 CUCAGCCUACCCCGCGUC UACAUACCCCCGAUGGCAUCGACCCUUGGCCCUUAGGAAAACCCCCGGGCCCUGCCCGCGU UCCUGAUGGCUGACUCCCGUUCUUGAUGGUUAACUAGAAGCUGCUCAGCAAAUCCCAAUCA 737 UCAGGGCCCAACCUGAGCACCC GCUCUCGCCUCGAUGGGAUCUCAUCGUGUCACCGAUGCAUCCAUUCGGGCCCUCCUGACCU UCAUGCCGCCGCAAUCCCGUAGUCUCUAGUUGGCGUGUAGGUAGUCUGGAAACACACCUCG 738 ACCCGCUUAUACACUCAACCUCCCUACACCUC UCCAAGCAGCGGGGUUAGUUGAAAAGAGUUCCCCAGGAAUCCACUUGGGUGUCCGCGGCCG UGCUGACGCAGGAGCUUUAGAGACACUAAUUCGCACGGAUCUAUCACUUAGCACUGCGUCC 739 UACGUAGUCUCGGCCGUCUAUCAUCGGAUCAUUCUGGCAUACCCUUGGGUCCUCGCCCCCU AUCCGAGCUUGGACUUCUGUACUCUUUGUAUGACAUGCCUUUAUUCGGUCGUAAGACAGUU 740 AGAGCGGUCUUGUCGCCAUCUCCCACGCC CUGAGGCUAUCUAUAGAGAAUGACCGAGUUCCCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCAGACGUGGCUAGCCAGCAAUCGAAAAUAAUCCCCGAACUAACAAUGGGCACUUCGUGG 741 CUGAAGCAAUAUACGGGAGAAAGAGUUGUUACCCAGGAAUCCACUUGGGACGUCCCCGCCC UACUGCUGUUCGAACGCUGUAGAUGAAAGUUAGGUGUGCACCCACCAUGGGGACUGCGCUU 742 CUGAAGCAAUAUACGGGAGAAAGAGUUGUUACCCAGGAAUCCACUUGGGACGCCGCGGACC UACUGCGGUUGCAACCCCGUUGAUGAAAGUUAGGUAUGCGCCCACCAUGGGCACCGCCCCC 743 CUGAGGCUAUCUAUAGAGUAUGACCGAGUUCCCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCAGACGUGGCUAGCCAGCACUCGAGAAUUAUCCCGGAUACACCACUGGGGACUUCGCCC 744 GUGCAGGGCCCUCGUCCGGGUGUGCCCCAAAUAAACUCAGGAACGCCCCGGUGCUC 745 AACCUCCCACUUUGUCUGUACAUACUGGCCUCUGUGAUUACAUAGAUCAGCCAUUAAAAUA AAACAAGCCUUAAUCUGCCUUCC 746 AAGACCGUUUCAAAAGAGAUUUACUUUUUUAAAGGACUUUAUCUGAACAGAGAGAUAUAAU AUUUUUCCUAUUGGACAAUGGACUUGCAAAGCUUCACUUCAUUUUAAGAGCAAAAGACCCC AUGUUGAAAACUCCAUAACAGUUUUAUGCUGAUGAUAAUUUAUCUACAUGCAUUUCAAUAA 747 ACCUUUUGUUUCCUAAGACUAGA GAGCCUUCUGAGCCCAGCGACUUCUGAAGGGCCCCUUGCAAAGUAAUAGGGCUUCUGCCUA AGCCUCUCCCUCCAGCCAAUAGGCAGCUUUCUUAACUAUCCUAACAAGCCUUGGACCAAAU 748 GGAAAUAAAGCUUUUUGAUGCA CAACUGGCCGGUCUGCAAGUCAGAGGAUGGCCAGUGUCUGUCCCGGGGUCCUGUGGCAGGC AGCGCCAAGCAACCUGGGUCCAAAUAAAAACUAAAUUGUAAACUCCUGAAA 749 GGGCCGGGCGGGGAGCGGGGCGGGGCCGGGGAAAGAUCGCGGGCGGGCGGGGCUCCUGGGG AGCGGGACCGAAGCUGGGGGCGGGCGACGGGCCGGAGCCCAGCGCCUUUGGGGAUUCGGUG 750 GGCGAGCCCUG AUGCUGCACAAAGUUACCUUCUGUUUCAUCAUUGCAAACAAAAAUCAUUGAAAAUACUAUG CCGCAUUCAUUUAAAGCUAUUUUGUUUACUAUGUAUAAAAGUCUACAAUCUAAUUAAUAGC AAUACUAGAUGUUUAUUAUUAGAAAAGAUUGCUGAGAGUAUUUAUCAGGUUUUACAAAGUC 751 AUUUUAAGAAAGCAAGAUACUGAUGUUA CUCUAUCACAGUCCUGCCAUGAUGAGCCCUGUUCCUGCUCAUCAUGAAGAUCCCCGCGAUA CUUCAACGCCUUCUGACUUCCAGGUGAUGACUGGGCCCCCAAUAAAUCCCGUCUUUGGGUC 752 CCUCCAGACAAGGAGCCACCAGAUUGGAUGGGAGCCCCCACACUCCCUCCUUAAAACACCA CCCUCUCAUCACUAAUCUCAGCCCUUGCCCUUGAAAUAAACCUUAGCUGCCCCACA 753 AGGGACCAUCCAGACCCUCCCUUCUUGCUGGGGAGGGGACGAGUUCUACCCACCUCCCCAC754ACUGGCACUCAGCCAGCUGCCUCCUUCCAGAGCAAUUAAAAGUCUUAGCAACAGUCCUCUGAttorney Docket No.: 62801.85WO01GUCCCACAGCUGAGUUUAUUAUACUUGUUUUCUUUUACAAAAUUAAAAACAUCUAAAACCA GG CACCAACCACCUUAGAUGGUGCCGACCUCACCCGCUCCCCUCAGUGGCGCACAGGCAUGCC GCUUCUCCCCACAGACGCAAAGUGACUGUGCUGGCAUCCAGCAGAUCCCCAUGGCCAGGAC UCUCCAGGCCCCACCAGAGCAGACAACUGUGGUGGGCAGGACGCUUGCUGGAACCCAUCAG 755 ACACCUGGUCCCCAAAACCAGACCCACCCACCUCCACCCAAUCAGUGGAAGUGCCAGGAAA CAAA UAGCGUCGGCUCAGAGCCCUGGUACCUUGGACCCAAGAGGAGGCCCAUCAUCUUCCUGGAG UAACAUCACCAGUGACCAGCAGACAGUGAGCUUCUAUCCCAGGCCCUGCAGCCAGUACACC 756 AAGGCUGUAGGG GCCCAUCGUGACUCAAAACUCACUUGUAUAAUAAACAGUUUUUGAGGGAUUUUAAAGUUUC AAGAACUGUGUGUGGCCUUAUGUGUUGGUAUUGGAUGUUUAACCAGACAGAAAUCAGUAAA 757 CAUCCUGGACCUAU GGAAUUGCACAUGAGAUGGCACACAUAUUUAUGCUGUCUGAAGGUCACGAUCAUGUUACCA UAUCAAGCUGAAAAUGUCACCACUAUCUGGAGAUUUCGACGUGUUUUCCUCUCUGAAUCUG 758 UUAUGAACACGUUGGUUGGCUGGAUUCAGUAAUAAAUAUGUAAGGCCUUUCUUUUUAA CCUGUAUUCCACUUACUCCACCUUCCAUUCCUCGCCCUGUCCCCACAGCCGAGUCCUGCAU CAGCCCUUUAUCCUCACACGCUUUUCUACAAUGGCAUUCAAUAAAGUGUAUAUGUUUCUGG 759 UGC UGCAAGGCUGGCCGGAAGCCCUUGCCUGAAAGCAAGAUUUCAGCCUGGAAGAGGGCAAAGU GGACGGGAGUGGACAGGAGUGGAUGCGAUAAGAUGUGGUUUGAAGCUGAUGGGUGCCAGCC 760 CUGCAUUGCUGAGUCAAUCAAUAAAGAGCUUUCUUUUGACCCA UGCAAGGCUGGCCGGAAGCCCUUGCCUGAAAGCAAGAUUUCAGCCUGGAAGAGGGCAAAGU GGACGGGAGUGGACAGGAGUGGAUGCGAUAAGAUGUGGUUUGAAGCUGAUGGGUGCCAGCC 761 CUGCAUUGCUGAGUCAAUCAAUAAAGAGCUUUCUUUUGACCC ACUAAGUUAAAUAUUUCUGCACAGUGUUCCCAUGGCCCCUUGCAUUUCCUUCUUAACUCUC UGUUACACGUCAUUGAAACUACACUUUUUUGGUCUGUUUUUGUGCUAGACUGUAAGUUCCU UGGGGGCAGGGCCUUUGUCUGUCUCAUCUCUGUAUUCCCAAAUGCCUAACAGUACAGAGCC 762 AUGACUCAAUAAAUACAUGUUAAAUGGAUGAAUGAA CCACUGCCGCCACCCCCAGCGCCACCACCGCUGCCGUCGCCACCGCGUUAUCCAUUCCUCG UAGGCUGGUCCUGGGGAACGGGUCGGCGGCCGGUCGGCUUCUGUUUUAUUAUUUUUUUUUU 763 AUUUUUUA CCGAGGCCUACACAGCAACCGCCAAGUGGCUCGCUGGCUGCUAUACGGGGACGCGGGCCGU UCCCACUGUAUCCAUUGUUGACAAGCUCUUCGCCGGAGGGUGGGCGGCUGUGGUGGGCCAU 764 UGCCACAG CCUUCGAGUGCGCCGUGCUGUGUCUGUAUCUGCUGUACCGAACCACCCACGAGUCCUCCCC CGAUCGCGAUCGCGCUCCCGUUGCGUUCGGGGACCUGCUGGCCCGCCUGCCGCGCUACCUG 765 GCGCGUCU GGUAUACCCGCCGCCAUUGGAUCGAGUGGGGCCCUAAAGAAGCCCUACACGUCCUCAUCGA CCCAAGCCCGGGCCUGCUCCGCGAGGUCGCUCGCGUUGAGCGCCGCUGGGUCGCACUGUGC 766 CUCCACAG UUGGUAUGCAAAAGUAUUCUACACUCCAGGGACCACCUGGUACUGGUAAGAGUCAUUUUGC UAUUGGCCUAGCUCUCUACUACCCUUCUGCUCGCAUAGUGUAUACAGCUUGCUCUCAUGCC 767 GCUGUUGA CUGCCGUCGCCACCGCGUUAUCCAUUCCUCGUAGGCUGGUCCUGGGGAACGGGUCGGCGGC CGGUCGGCUUCUGUUUUAUUAUUUUUUUUUUAUUUUUUAUCUUCUCCUUUCCUUAAUCUCG 768 GAUUAUCA GUGUACUCAAAUCAAACUAUUUCAACGAGACUUGGUUCUACAGCUGGUUCUGGAACCAGUG UCUCGAGCCUCCCGUCAACUGCAAGGACUAGGAGCUGGGUUGAGGACCAAAGUAGGAAUCU 769 GUCACCUU AAAGGGGUCCUCGGAGGAGGACCCCAAACACUACCUAGAUACAUGGAUUGGGAUGCUUAGU CCUUGCGUUCGUUGGCUGGUUCCGGAACGCUUUCCUUUGUAUGGUGGUGUACCUUUAGAUA 770 GGCCAGUG GACAUAAUAGUUUUUGGUUUGUUAUUAUUAGAUCAAUUGCUGGUAUGAUAAUGUACUUGGU ACUUGGUAUAAUACUGUUAUAUAUUUCAGAGAAGAAGAAUGAUAAUGAUAUUUCAAAGGAA 771AGUACUUCAttorney Docket No.: 62801.85WO01UAGUCAGGGUAAAGACUUUGGUUAUGUAUGUGAUGGUUCUUUUUAUAAAGCAACUGUUAAU CAAGUUUGUGUUUUAUUAGCUAAGAAGAUAGAUGUUUUGCUUACUGUAGAUGGUGUUAAUU 772 UUAAAUCU UUAUCCAAGAAACCCCACGGAGCAGGGCAACAUUGCAGGGCUCUGUUCACGCGAUGGUCGU CAUCUGGCUCUCCUGUGUGACCCCUCACUUUGUACAGACUUUUGGCAAUGGGAGCACAUUC 773 CCCCCGCC UUUUAUCAGUUUAUUAUCUUAGUUACUUAAGUGUUUUAUACUUUCACCUCUGUGUAUCUAU AUAAUCAAUGGGAUAAUUGUUCUUAAUCUAGUAGACUGUAGAAUUAGUUAAUUGGUAGGUU 774 GCAUUAGG AACACUCUGAAACUCCAAUUCCACUGGGAGGAAGUGGUGCAAUGUCAAUAAUGGAACUUUC AACAGCCGGUAUAGGUAUGUCUGACAAAAAUUUACUGAAACAAGCACUUAUUGGUUAUAUG 775 CAUAAACA UAUCCGUUCCUCGUAGGCUGGUCCUGGGGAACGGGUCGGCGGCCGGUCGGCUUCUGUUUUA UUUUUUUUUUUAUUUUUUAUCUUCUCCUUUCCUUAAUCUCGGAUUAUCAUUUCCCUCUCCU 776 ACCUACCA CCCGACUACCAUCAGCAGUACCACUGCCGCCACCCCCAGCGCCACCACCGCUGCCGUCGCC ACCGCGUUAUCCAUUCCUCGUAGGCUGGUCCUGGGGAACGGGUCGGCGGCCGGUCGGCUUC 777 UGUUUUAU CCACUGCCGCCACCCCCAGCGCCACCACCGCUGCCGUCGCCACCGCGUUAUCCAUUCCUCG UAGGAUUUUACUGGGGAACGGGUCGGCGGCCGGUCGGCUUCUGUUUUAUUAUUUUUUUUUU 778 AUUUUUUA CCGCACGGCCUUGGACGCCGCCGCACGUAAAUGGAAAGCCCACCAGGCGCGCAGCAGCGCC CUUGCACUCGUCACAGGCAUCCCAUGGCACCCGGUUGCGGGCGACAUGGGGGUCCUUGAGA 779 ACCCUGCC CACCCCCAGCGCCACCACCGCUGCCGUCGCCACCGCGUUAUCCAUUCCUCGUAGGCUGGUC CUGGGGAACGGGUCGGCGGCCGGUCGGCUUCUGUUUUAUUAUUUUUUUUUUAUUUUUUAUC 780 UUCUCCUU GCCGUGCGAUGCACCCUCCCUAUCCGCCACGUGCGCAGCCUCCAACCCAGCGCGCGGGUCC GACUCCCGGACCUCGUCCAUCUCGCCGAGGUGGGCCGGUGGCGGUGGUUCAGCCUCCCCCG 781 CCCCGUGU GACGCGGUGGCCACCAGCCACCAGACGAGCACCAGCCCCCACACAUCACCGCGGAACACAU GGACCAGUCCGACGGACAAGGCGCCGAUGGAGACAUGGAUAGUACACCCGCAAAUGGUGAG 782 ACAUCCGU CGCCGUCAUGCCGCGACUCCUCCAGGUUGUUCCGGUAGUUGCUUCGGUAUGUCCCUGGCCG AGGGAAACGAUCCCUGCGGUGAAGGAGGAAGAGCAGAAGGAAGAGGAGUUUCCCUGGAGCA 783 GCGCCGUA AACAUCCUCUCGAUCGGAUCGCAACGUGUUACCCAGGAAUCCACUUGGGUGUACGCGGCCG UUCUGACGUUGGAAUUCUGUAGAUGAAAGUUAGCUGAAUAAAGUCUGAGUGGGCGGC 784 AACAUCCUCUCGAUCGGAUCGCAAUUCUUGCCCCUUGGGCCUCCCCGUGUACGCGGCCGUU CUGACGUUGCACCCGUACCCCCGUGGUCUUUAGGAGCUUUUAAUUGGAAAUGAGAAC 785 GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCACUAUCAUCCUAAGAC GGUCCUUCUUCGGAUCGCAAUCUCACCCUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGC 786 GGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGG 787 GCGGC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGGACCAGGGCCGUCUUU 788 GAACUUUUCUAACUGUUCUUAC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CCAGCCCCUCCUCCCCUUCCUGUCACCCUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGC 789 GAAUAAAGUCUGAGUGGGCGGC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CCAGCCCCUCCUCCCCUUCCUGUCACCCUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGC 790GGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUACAttorney Docket No.: 62801.85WO01GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCCACCCGUACCCCCGUGGUCUUU 791 GAAUAAAGUCUGAGUGGGCGGC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCCACCCGUACCCCCGUGGUCUUU 792 GGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACCCUGGUGCCGCGCUUCCU 793 UCGGGAACUGCACCCGCGAAUAAAGUCUGAGUGGGCGGC GCUGGAGCCUCGGUGGCCUAGCCACUUCCUUCGGGUGAGCCCCUAAGCCAUGGUUGUACUG CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACCCUGGUGCCGCGCUUCCU 794 UCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGG 795 GCGGC AACAUCCUCUCGAUCGGAUCGCAAUUCUUGCCCCUUGGGCCUCCCCGUGUACGCGGCCGUU CUGACGUUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 796 ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGGACCAGGGCCGUCUUU 797 GAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CCAGCCCCUCCUCCCCUUCCUGUCACCCUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGC 798 GAAUAAAGUCUGAGUGGGCGGC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CCAGCCCCUCCUCCCCUUCCUGUCACCCUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGC 799 GGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCCACCCGUACCCCCGUGGUCUUU 800 GAAUAAAGUCUGAGUGGGCGGC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCCACCCGUACCCCCGUGGUCUUU 801 GGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACCCUGGUGCCGCGCUUCCU 802 UCGGGAACUGCACCCGCGAAUAAAGUCUGAGUGGGCGGC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCUUCUUGCCCCUUGGGCCUCCCC CACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACCCUGGUGCCGCGCUUCCU 803 UCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUU 804 GAAUAAAGUCUGAGUGGGCGGC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUU 805 GGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCCAGCCCCUCCUCCCCUUCCUGUCACCCUGGUGCCGCGCUUCCU 806 UCGGGAACUGCACCCGCGAAUAAAGUCUGAGUGGGCGGC AACAUCCUCUCGAUCGGAUCGCAAUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCC CUUCCUGGAAUUCUGUAGAUGAAAGUUAGCUAGGAGCUUUUAAUUGGAAAUGAGAAC 807 ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCCAGCCCCUCCUCCCCUUCCUGUCACCCUGGUGCCGCGCUUCCU 808 UCGGGAACUGCACCCGCGGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCCACCC 809GUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAttorney Docket No.: 62801.85WO01ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCCACCC 810 GUACCCCCGUGGUCUUUGGACCAGGGCCGUCUUUGAACUUUUCUAACUGUUCUUAC ACCCUUUGCCCACUCCUCCAUGGUGAUAUAAAGACCACCCACUUCCUUCGGGUGAGCCCCU AAGCCAUGGUUGUACUGCACUAUCAUCCUAAGACGGUCCUUCUUCGGAUCGCAAUCUCACC 811 CUGGUGCCGCGCUUCCUUCGGGAACUGCACCCGCGAAUAAAGUCUGAGUGGGCGGC GCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCU UCCUGCACCCGUACCCCCGUGGUCUUUAGGUAUGCUCCCACCUCCACCUGCCCCACUCACC 812 ACCUCUGCUAGUUCCAGACA...

Claims

Attorney Docket No.: 62801.85WO01CLAIMSWhat is Claimed Is:

1. An isolated nucleic acid molecule comprising an engineered 5' untranslated region (5' UTR) comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

2. An isolated nucleic acid molecule comprising, in the following order,an engineered 5' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; andan open reading frame encoding an RNA transcript or protein (e.g., a protein).

3. The isolated nucleic acid molecule of claim 1 or 2, wherein the engineered 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

4. The isolated nucleic acid molecule of any one of claims 1-3, wherein the engineered 5' UTR comprises a nucleotide sequence at 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

5. The isolated nucleic acid molecule of any one of claims 1-4, wherein the engineered 5' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018.

6. An isolated nucleic acid molecule comprising an engineered 3' untranslated region (3' UTR) comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%. 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

7. An isolated nucleic acid molecule comprising, in the following order,an open reading frame encoding an RNA transcript or protein (e.g., a protein); and an engineered 3' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.Attorney Docket No.: 62801.85WO018. The isolated nucleic acid molecule of claim 6 or 7, wherein the engineered 3' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

9. The isolated nucleic acid molecule of any one of claims 6-8, wherein the engineered 3' UTR comprises a nucleotide sequence at 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

10. The isolated nucleic acid molecule of any one of claims 6-9, wherein the engineered 3' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

11. An isolated nucleic acid molecule comprising a 5' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and a 3' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

12. An isolated nucleic acid molecule comprising, in the following order,a 5' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018;an open reading frame encoding an RNA transcript or protein (e.g., a protein); and a 3' UTR comprising a nucleotide sequence at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

13. The isolated nucleic acid molecule of claim 11 or 12, wherein the 5' UTR and the 3' UTR are a pair set forth in Table 6, Table 7 or Table 8.

14. The isolated nucleic acid molecule of any one of claims 11-13, wherein the 5' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and the 3' UTR comprises a nucleotide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS; 1-1505.Attorney Docket No.: 62801.85WO0115. The isolated nucleic acid molecule of any one of claims 11-14, wherein the 5' UTR comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018: and the 3' UTR comprises a nucleotide sequence at least 95%, 96%, 97%, 98%, 99%, or 100% identical to the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

16. The isolated nucleic acid molecule of any one of claims 11-15, wherein the 5' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1506-3018; and the 3' UTR comprises the nucleotide sequence set forth in any one of SEQ ID NOS: 1-1505.

17. The isolated nucleic acid molecule of any one of the preceding claims, wherein the nucleic acid molecule is an RNA molecule.

18. The isolated RNA molecule of claim 17, wherein the RNA molecule is a translatable polyribonucleotide.

19. The isolated RNA molecule of claim 17 or 18, wherein the RNA molecule is an mRNA molecule.

20. The isolated RNA molecule of any one of claims 17-19, wherein the RNA molecule is a circular RNA molecule.

21. The isolated RNA molecule of any one of claims 17-20, wherein the RNA molecule comprises one or more translation regulatory elements.

22. The isolated RNA molecule of any one of claims 17-21, wherein the RNA molecule (e.g., the open reading frame) comprises a translation initiation element (e.g., a start codon).

23. The isolated RNA molecule of claim 22, wherein the translation initiation element is a start codon (e.g., AUG, CUG, GUG, UUG, ACG. AUC, AUU. AAG, AUA, or AGG).

24. The isolated RNA molecule of any one of claims 17-23, wherein the RNA molecule (e.g., the open reading frame) comprises a translation termination element (e.g., a stop codon).

25. The isolated RNA molecule of claim 24, wherein the translation termination element comprises a stop codon (e.g., UAA, UGA, or UAG).

26. The isolated RNA molecule of any one of claims 17-25, wherein the RNA molecule comprises an internal ribosome entry site (IRES).

27. The isolated RNA molecule of any one of claims 17-26, wherein the RNA molecule comprises a stagger element.Attorney Docket No.: 62801.85WO0128. The isolated RNA molecule of claim 27, wherein the stagger element comprises a 2A-like sequence.

29. The isolated RNA molecule of any one of claims 17-28, wherein the RNA molecule comprises a 5' cap structure.

30. The isolated RNA molecule of any one of claims 17-29, wherein the RNA molecule lacks a 5' cap structure.

31. The isolated RNA molecule of any one of claims 17-30, wherein the RNA molecule comprises a poly(A) sequence, a poly(U) sequence, a poly(A)(U) sequence, and / or a poly(A)(C) sequence.

32. The isolated RNA molecule of any one of claims 17-31, wherein the RNA molecule comprises a 3' poly (A) sequence.

33. The isolated RNA molecule of any one of claims 17-32, wherein the RNA molecule lacks a 3' poly (A) sequence.

34. The isolated RNA molecule of any one of claims 17-33, wherein the RNA molecule lacks a 3' poly(A) sequence greater than 10, 15, 20, 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, or 500 nucleotides.

35. The isolated RNA molecule of any one of claims 17-34, wherein the RNA molecule is a circular RNA molecule that lacks a 5' cap structure and lacks 3' poly(A) sequence.

36. The isolated RNA molecule of any one of claims 17-35, wherein the RNA molecule is a circular RNA molecule that lacks a 5' cap structure and lacks 3' poly(A) sequence greater than 10, 15, 20, 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, or 500 nucleotides.

37. The isolated RNA molecule of any one of claims 17-36, wherein the RNA molecule is an mRNA molecule comprising a 5’-cap structure and a 3' poly(A) sequence.

38. The isolated RNA molecule of any one of claims 17-37, wherein the nucleotide sequence of the RNA molecule is codon optimized.

39. The isolated nucleic acid molecule of any one of claims 1-17, wherein the nucleic acid molecule is a DNA molecule.

40. The isolated DNA molecule of claim 39, wherein the DNA molecule is a transcribable polynucleotide.

41. The isolated DNA molecule of claim 39 or 40, wherein the DNA molecule comprises one or more transcriptional regulatory elements.Attorney Docket No.: 62801.85WO0142. The isolated DNA molecule of any one of claims 39-41, wherein the DNA molecule comprises one or more promoter.

43. The isolated DNA molecule of any one of claims 39-42, wherein the DNA molecule comprises an enhancer.

44. The isolated DNA molecule of any one of claims 39-43, wherein the DNA molecule comprises an intron.

45. The isolated DNA molecule of any one of claims 39-44, wherein the DNA molecule comprises transcription termination sequence.

46. The isolated DNA molecule of any one of claims 39-45, wherein the DNA molecule comprises a posttranscriptional regulatory element.

47. The isolated DNA molecule of any one of claims 39-46, wherein the DNA molecule comprises a poly(A) signal sequence.

48. The isolated DNA molecule of any one of claims 39-47, wherein the DNA molecule comprises an inverted terminal repeat (ITR).

49. The isolated DNA molecule of any one of claims 39-48, wherein the DNA molecule comprises a 5' ITR and a 3' ITR.

50. The isolated DNA molecule of any one of claims 39-49, wherein the DNA molecule comprises, in the following order, a 5' ITR, the engineered promoter, the open reading frame, and a 3' ITR.

51. The isolated nucleic acid molecule of any one of the preceding claims, wherein the nucleic acid molecule comprises at least one modified nucleotide.

52. The isolated nucleic acid molecule of any one of the preceding claims, wherein the nucleic acid molecule comprises at least one modified nucleobase.

53. The isolated nucleic acid molecule of any one of the preceding claims, wherein the nucleic acid molecule comprises at least one modified sugar moiety.

54. The isolated nucleic acid molecule of any one of the preceding claims, wherein the nucleic acid molecule comprises at least one modified internucleoside linkage.

55. The isolated nucleic acid molecule of any one of the preceding claims, comprising a plurality of open reading frames, each encoding an RNA transcript or protein.Attorney Docket No.: 62801.85WO0156. The isolated nucleic acid molecule of any one of the preceding claims, wherein each open reading frame of the plurality encodes a protein; or wherein each open reading frame of the plurality encodes a different protein.

57. The isolated nucleic acid molecule of any one of the preceding claims, wherein each open reading frame of the plurality encodes an RNA transcript.

58. The isolated nucleic acid molecule of any one of the preceding claims, wherein each open reading frame of the plurality encodes a different RNA transcript.

59. The isolated nucleic acid molecule of any one of the preceding claims, wherein the open reading frame encodes a protein.

60. The isolated nucleic acid molecule of any one of the preceding claims, wherein the protein is a therapeutic protein.

61. The isolated nucleic acid molecule of any one of the preceding claims, wherein the protein (e.g., therapeutic protein) is an immunogen e.g., viral, bacterial, fungal).

62. The isolated nucleic acid molecule of any one of the preceding claims, wherein the protein {e.g., therapeutic protein) comprises an antibody (or a functional fragment or variant thereof) or a fusion protein.

63. The isolated nucleic acid molecule of any one of the preceding claims, wherein the protein {e.g., therapeutic protein) is a hormone, enzyme, growth factor, blood protein, a clotting factor, transcription factor, cytokine, chemokine, chimeric antigen receptor, T-cell receptor, or nuclease {e.g., endonuclease).

64. The isolated nucleic acid molecule of any one of the preceding claims, wherein the open reading frame encodes an RNA transcript.

65. The isolated nucleic acid molecule of any one of the preceding claims, wherein the RNA transcript is a tRNA, miRNA, siRNA, antisense oligonucleotides (ASO), IncRNA, rRNA, snRNA, microRNA, piRNA, snoRNA, snRNA, exRNA, scaRNA, Y RNA, or hnRNA66. A vector comprising the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, or the DNA molecule of claim 39-50.

67. The vector of claim 66, wherein the vector is a plasmid or a viral vector.

68. A carrier comprising the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, or the vector of any one of claims 66-67.Attorney Docket No.: 62801.85WO0169. The carrier of claim 68, wherein the carrier is a lipid nanoparticle (LNP), liposome, lipoplex, or nanoliposome.

70. The carrier of claim 69, wherein the carrier is an LNP.

71. The carrier of claim 69 or 70, wherein the LNP comprises a cationic lipid, a neutral lipid, a cholesterol, and / or a PEG lipid.

72. The carrier of any one of claims 69-70, wherein the LNP comprises a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid.

73. The carrier of any one of claims 69-72, wherein the LNP has a mean particle size of between 80 nm and 160 nm.

74. A cell (e.g., host cell) or a population of cells (e.g., a population of host cells) comprising the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, or the carrier of any one of claims 68-73.

75. A pharmaceutical composition comprising the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, or the cell or population of cells of claim 74, and a pharmaceutically acceptable excipient.

76. A vaccine composition comprising the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, or the cell or population of cells of claim 74.

77. The vaccine composition of claim 76, wherein the protein (e.g., therapeutic protein) comprises an immunogen.

78. A kit comprising the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38. the DNA molecule of any one of claims 39-50. the vector of any one of claims 66-67, the carrier of any one of claims 68-73, the cell or population of cells of claim 74, the vaccine composition of any one of claims 76-77, or the pharmaceutical composition of claim 75, and optionally comprising instructions for use of the foregoing.

79. An in vitro method of making a protein (e.g., a therapeutic protein), the method comprising(a) culturing a population of cells in vitro,Attorney Docket No.: 62801.85WO01(b) introducing the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, or the carrier of any one of claims 68-73, to the population of cells; and(c) culturing the population of cells under conditions and for a period of time sufficient to allow for expression of the protein (e.g., therapeutic protein); and(d) optionally isolating and / or purifying the expressed protein (e.g., therapeutic protein).

80. A method of delivering an RNA molecule, a DNA molecule, a vector, or a carrier to a cell, the method comprising delivering to the cell the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, the cell or population of cells of claim 74, the vaccine composition of any one of claims 76-77. or the pharmaceutical composition of claim 75, to thereby deliver the RNA molecule, the DNA molecule, the vector, or the carrier to the cell.

81. The method of claim 80, wherein the method is in vitro.

82. The method of claim 80, wherein the cell is in vitro or ex vivo.

83. The method of claim 80, wherein the cell is in a subject.

84. A method of delivering an RNA molecule, a DNA molecule, a vector, a carrier, a cell, vaccine composition, or pharmaceutical composition to a subject in need thereof, the method comprising administering to the subject the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, the cell or population of cells of claim 74, the vaccine composition of any one of claims 76-77, or the pharmaceutical composition of claim 75, to thereby deliver the RNA molecule, the DNA molecule, the vector, the carrier, the cell, the vaccine composition, or the pharmaceutical composition to the subject.

85. A method of expressing a protein (e.g., a therapeutic protein) in a cell, the method comprising delivering to the cell the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, the cell or population of cells of claim 74, the vaccine composition of any one of claims 76-77, or the pharmaceutical composition of claim 75, to thereby express the protein in the cell.

86. The method of claim 85, wherein the method is in vitro.Attorney Docket No.: 62801.85WO0187. The method of claim 85, wherein the cell is in vitro or ex vivo.

88. The method of claim 85, wherein the cell is in a subject.

89. A method of expressing a protein (e.g., a therapeutic protein) in a subject in need thereof, the method comprising administering to the subject the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, the cell or population of cells of claim 74, the vaccine composition of any one of claims 76-77, or the pharmaceutical composition of claim 75, to thereby express the protein (e.g., therapeutic protein) in the subject.

90. A method of treating, ameliorating, or preventing a disease in a subject in need thereof, the method comprising administering to the subject the nucleic acid molecule of any one of claims 1-65, the RNA molecule of any one of claims 17-38, the DNA molecule of any one of claims 39-50, the vector of any one of claims 66-67, the carrier of any one of claims 68-73, the cell or population of cells of claim 74, the vaccine composition of any one of claims 76-77, or the pharmaceutical composition of claim 75, treat, ameliorate, or prevent the disease in the subject.

91. A method of treating, ameliorating, or preventing a disease in a subject in need thereof, the method comprising administering to the subject the protein made by the method of claim 79 (or a pharmaceutical composition comprising the same), treat, ameliorate, or prevent the disease in the subject.

92. The method of claim 90 or 91, wherein the disease is a proinflammatory disease (e.g., an autoimmune disease), an immunosuppressive disease, a cancer, a hormone related disease, a growth factor related disease, a blood clotting disease, or a genetic disease.

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