Light irradiation device and light irradiation system

Abstract

This light irradiation device 2 is an elongated medical device, and comprises a rotation transmission member 20, a laser light source 11, and conducting wires 14A, 14B. The rotation transmission member 20 has an elongated shape and is hollow. The rotation transmission member 20 transmits rotation between the proximal side and the distal side. The laser light source 11 is connected to the rotation transmission member 20 at the distal end of an elongated device body 210. The laser light source 11 emits laser light from the distal end of the device body 210. The conducting wires 14A, 14B extend from the proximal side to the distal side along the rotation transmission member 20 and are electrically connected to the laser light source 11. The conducting wires 14A, 14B are disposed outside the hollow rotation transmission member 20.

Description

Light Irradiation Device and Light Irradiation System 【0001】 The present disclosure relates to a light irradiation device and a light irradiation system that are inserted into a living body lumen or the like to irradiate light. 【0002】 In recent years, research on photoimmunotherapy, a technique for treating diseases, has been conducted. In photoimmunotherapy, after a drug that accumulates in cells in the diseased area (e.g., cancer cells, etc.) is administered to the living body, light (e.g., near-infrared light, etc.) is irradiated to the diseased area. As a result, the drug reacts to the light and the cells in the diseased area are destroyed. 【0003】 In photoimmunotherapy, a technique has been proposed for irradiating light from a position closer to cancer cells rather than irradiating light from the body surface. For example, the light irradiation device described in Patent Document 1 has a laser light source at its tip. The laser light is directly irradiated from the laser light source to a specific position of the living body without passing through an optical transmission member (e.g., an optical fiber, etc.). 【0004】 Japanese Patent No. 7444519 【0005】 Considering the ease of insertion of the light irradiation device into the living body and the operability in the living body, it is desirable that the diameter of the light irradiation device be as small as possible, and it is also desirable that the flexibility of the device body be appropriately adjusted. However, when providing members that require connection of conductors, such as a laser light source and a sensor, at the tip of the light irradiation device, it is necessary to arrange the conductors extending from the base end side to the tip end side in the device body and electrically connect them to the members at the tip end. If the conductors are not appropriately arranged, it becomes difficult to reduce the diameter and adjust the flexibility of the light irradiation device. 【0006】 A typical object of the present disclosure is to provide a light irradiation device and a light irradiation system that are easy to reduce the diameter and adjust the flexibility while providing members that require connection of conductors at the tip end. 【0007】A first embodiment of a light irradiation device provided by a typical embodiment of the present disclosure is a long-shaped medical light irradiation device comprising: a hollow rotation transmission member having a long external shape and transmitting rotation between a base end and a tip end; a laser light source connected to the rotation transmission member at the tip of the long-shaped device body and emitting laser light; and a conductor extending from the base end to the tip end along the rotation transmission member and electrically connected to the laser light source, wherein the conductor is arranged outside the hollow rotation transmission member. 【0008】 A second aspect of the light irradiation device provided by a typical embodiment of the present disclosure is a long-shaped medical light irradiation device comprising: a hollow rotation transmission member having a long external shape and transmitting rotation between a base end and a tip end; a laser light emitting section that emits laser light from the tip end of the long-shaped device body; a light sensor disposed at the tip end of the device body; and a conductor extending from the base end to the tip end along the rotation transmission member and electrically connected to the light sensor, wherein the conductor is disposed on the outside of the hollow rotation transmission member. 【0009】 A first aspect of a light irradiation system provided by a typical embodiment of the present disclosure is a medical light irradiation system comprising a catheter formed in the shape of an elongated tube, and an elongated light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device has an elongated outer shape and comprises a hollow rotation transmission member that transmits rotation between a proximal end and a distal end, a laser light source connected to the rotation transmission member at the distal end of the elongated device body and emitting laser light, and a conductor extending along the rotation transmission member from the proximal end to the distal end and electrically connected to the laser light source, wherein the conductor is positioned outside the hollow rotation transmission member. 【0010】A second aspect of the light irradiation system provided by a typical embodiment of the present disclosure is a medical light irradiation system comprising a catheter formed in the shape of an elongated tube, and an elongated light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device has an elongated outer shape and comprises a hollow rotation transmission member that transmits rotation between a proximal end and a tip end, a laser light emission part that emits laser light from the tip end of the elongated device body, a light sensor disposed at the tip end of the device body, and a conductor that extends from the proximal end to the tip end along the rotation transmission member and is electrically connected to the light sensor, wherein the conductor is disposed on the outside of the hollow rotation transmission member. 【0011】 According to the light irradiation device and light irradiation system described herein, it is possible to easily adjust the diameter and flexibility while providing a component at the tip that is necessary for connecting a conductor. 【0012】 A first aspect of the light irradiation device of the present disclosure is a long, slender medical light irradiation device comprising a rotational transmission member, a laser light source, and a conductor. The rotational transmission member is long and hollow. The rotational transmission member transmits rotation between its base and tip ends. The laser light source is connected to the rotational transmission member at the tip end of the long device body. The laser light source emits laser light from the tip end of the device body. The conductor extends along the rotational transmission member from the base end to the tip end and is electrically connected to the laser light source. The conductor is positioned outside the hollow rotational transmission member. 【0013】According to a first embodiment of the optical irradiation device of this disclosure, the conductor connected to the laser light source at the tip is arranged on the outside of the hollow portion of the rotational transmission member, rather than inside. When the conductor is arranged in the hollow portion of the rotational transmission member, it is essential to secure space for the conductor in the hollow portion of the rotational transmission member. In contrast, when the conductor is arranged on the outside of the rotational transmission member, it is not necessary to secure space for the conductor in the hollow portion, making it easier to freely select the diameter of the rotational transmission member used in the optical irradiation device. Therefore, it becomes easier to miniaturize (thin) the optical irradiation device by reducing the area of ​​the portion surrounded by the outermost surface of the optical irradiation device when viewed in a cross-section intersecting the extension direction. Furthermore, since the diameter of the rotational transmission member to be used can be easily selected, it becomes easier to adjust the flexibility of the optical irradiation device (i.e., the flexibility in the direction intersecting the extension direction of the device) which changes according to the diameter of the rotational transmission member, etc. Therefore, insertion and manipulation of the optical irradiation device into a living organism becomes easier. As described above, the optical irradiation device of this disclosure makes it possible to appropriately achieve both miniaturization and flexibility adjustment while providing a laser light source at the tip that requires the connection of a conductor. Furthermore, since conductors are often easily deformed and difficult to handle, it is often difficult to place them in the hollow portion of a rotational transmission member. In contrast, placing the conductors on the outside of the rotational transmission member improves workability when manufacturing light irradiation devices. 【0014】 Furthermore, since conductors are often easily deformed and difficult to handle, it is often difficult to place them in the hollow portion of a rotational transmission member. In contrast, placing the conductors on the outside of the rotational transmission member improves workability when manufacturing light irradiation devices. 【0015】The hollow portion of the rotational transmission member may serve as a coolant flow channel for passing coolant to cool the laser light source from the base end to the laser light source. In the light irradiation device of this disclosure, since no wires are placed in the hollow portion of the rotational transmission member, the hollow portion can be used as a coolant flow channel. By flowing coolant through the hollow portion of the rotational transmission member, the heat dissipation of the laser light source is ensured, and the insertion and manipulation of the light irradiation device into a living organism becomes easier. In other words, by placing the wires on the outside of the rotational transmission member, both ensuring the heat dissipation of the laser light source and improving the operability of the device by adjusting the diameter and flexibility are appropriately achieved. 【0016】 The tip of the rotation transmission member may have an open end that exposes the hollow portion to the outside. The coolant that has passed through the hollow portion of the rotation transmission member may be discharged from the open end towards the laser light source. In this case, the coolant that has passed through the hollow portion of the rotation transmission member flows appropriately towards the laser light source, making it easier to cool the laser light source more effectively. 【0017】 The light irradiation device may further include a coating layer. The coating layer covers the rotary transmission member and the outer circumference of the conductor located outside the rotary transmission member. As an example, the coating layer of this disclosure tightly covers the rotary transmission member and the outer circumference of the conductor located outside the rotary transmission member. In this case, the position of the conductor outside the rotary transmission member is appropriately maintained while preventing leakage of fluid (e.g., coolant) from the rotary transmission member to the outside and preventing fluid from entering the rotary transmission member from the outside. Furthermore, when coolant is flowed through the hollow portion of the rotary transmission member, since there is no coating layer between the rotary transmission member and the conductor, the conductor is also more easily cooled by the coolant passing through the hollow portion of the rotary transmission member. Since the conductor is connected to a laser light source, the cooling of the conductor makes it easier for heat from the laser light source to be released into the coolant through the conductor. Thus, both ensuring the heat dissipation of the laser light source and improving the operability of the device are more appropriately achieved. 【0018】As an example, the coating layer of this disclosure employs a heat-shrinkable tube that shrinks and adheres tightly when heat is applied while covering the rotary transmission member and the outer circumference of the conductor arranged outside the rotary transmission member. However, it is also possible to change the specific method for maintaining the position of the conductor outside the rotary transmission member. For example, a coating layer other than a heat-shrinkable tube may be used. In addition, an adhesive or the like may be used to bond the conductor to the outside of the rotary transmission member, either together with the coating layer or in place of the coating layer. In this case, the conductor becomes more firmly fixed to the rotary transmission member. For example, conductors are often easily deformed and difficult to handle, but by temporarily fixing the conductor to the outside of the rotary transmission member with an adhesive and then placing a heat-shrinkable tube around the outer circumference of the rotary transmission member and the conductor, workability can be easily improved. The material of the adhesive can also be appropriately selected. For example, materials that harden by heat or ultraviolet light, such as epoxy resin, silicone resin, and acrylic resin, may be used as the material of the adhesive. 【0019】 The light irradiation device may further include a covering layer that covers the outer circumference of the rotation transmission member. The conductor may be located outside the covering layer that covers the outer circumference of the rotation transmission member. 【0020】 In this case, the coating layer effectively prevents leakage of fluid (e.g., coolant) from the rotating transmission member to the outside, and prevents fluid from entering the rotating transmission member from the outside. Furthermore, when coolant is flowed through the hollow portion of the rotating transmission member, the coating layer is interposed between the rotating transmission member and the conductor, making it difficult for the temperature of the coolant to rise due to heat conducted through the conductor. As a result, the coolant is more likely to reach the vicinity of the laser light source at a lower temperature. Therefore, the laser light source is more easily cooled. The conductor can be fixed to the outside of the coating layer using various materials such as adhesives. The same configuration as described above can be used for the coating layer. 【0021】 The laser light source may be covered and sealed with a sealing member. At least the portion of the sealing member located in the path of the laser light may be made of a light-transmitting material (e.g., a light-transmitting resin). In this case, various problems caused by liquids or other substances adhering to the laser light source are appropriately suppressed. 【0022】 The conductor may be an insulated conductor or a flexible printed circuit board (FPC substrate). The conductor may form two or more transmission lines to the laser light source (lines that transmit at least one of power and / or signals to the laser light source). In this case, the shape of the conductor also changes appropriately in accordance with the change in the shape of the rotation transmission member. Furthermore, power and signals are properly supplied to the laser light source. Thus, the light irradiation device is properly driven. 【0023】 Furthermore, a flexible substrate equipped with multiple transmission lines (for example, a positive transmission line and a negative transmission line) may be used as the conductor. In this case, the number of conductors fixed to the outside of the rotation transmission member can be reduced, making it easier to reduce the amount of work required when manufacturing the light irradiation device. 【0024】 When viewing the shape of the conductor in a cross-section perpendicular to the axis of the rotational transmission member, the width of the conductor in the circumferential direction of the axis may be greater than the thickness of the conductor. In this case, it becomes easier to minimize the thickness of the conductor, and thus easier to reduce the overall diameter of the light irradiation device. Furthermore, the holding state of the conductor on the outside of the rotational transmission member also becomes more stable. 【0025】 A support for the laser light source may be provided at the tip of the device body. The support and the rotation transmission member may be directly or indirectly fixed to each other. In this case, the relative positional relationship between the tip of the rotation transmission member and the laser light source is stabilized. Therefore, the operability of the light irradiation device is further improved. Also, if coolant is flowed through the hollow portion of the rotation transmission member, the flow of coolant supplied to the laser light source through the hollow portion is also stabilized, so the laser light source is cooled more effectively. 【0026】The light irradiation device may further include an intermediate member that interposes between the support and the rotational transmission member to join them together. Using an intermediate member improves the degree of freedom in fixing compared to directly joining the support and the rotational transmission member, making it easier to fix the support and the rotational transmission member more securely. The material of the intermediate member can be at least one of various materials, such as resin (adhesive may also be used) and metal. 【0027】 At least a portion of the intermediate member may be made of a radiopaque material (for example, at least one of platinum and tungsten). In this case, a medical professional (e.g., a surgeon) can appropriately adjust the laser beam irradiation position by checking the position of the intermediate member in the captured image while irradiating the biological tissue with a light irradiation device, while taking images of the inside of the body using radiation (e.g., X-rays). This makes it easier to improve the accuracy of treatment. 【0028】 The light irradiation device may further include a light transmission member. The light transmission member may be elongated and receive light from the tip of the device body from which laser light is emitted by a laser light source, and transmit the incident light to a light sensor provided at the base end. In this case, it is not necessary to provide the light sensor at the tip of the light irradiation device. Therefore, the configuration of the tip of the light irradiation device can be simplified and miniaturized, while the state of light at the tip of the light irradiation device can be appropriately detected by the light sensor provided at the base end. 【0029】 The optical transmission member may be an optical fiber. In this case, the laser light source is properly transmitted to the tip of the main end of the device. 【0030】 For example, it is possible to use a single-mode optical fiber as an optical transmission material. In this case, the light transmitted by the optical transmission material is transmitted to the optical sensor with suppressed phase changes compared to when a multimode optical fiber is used. Therefore, the state of light at the tip of the optical irradiation device can be grasped more accurately. 【0031】It should be noted that single-mode optical fibers have a smaller core diameter than multimode optical fibers, and are therefore often unsuitable for transmitting high-density light such as therapeutic laser light. However, the light density of detection light transmitted to an optical sensor is lower than that of therapeutic laser light, so single-mode optical fibers can adequately transmit the detection light to the optical sensor. However, it is also possible to use multimode optical fibers as optical transmission materials. 【0032】 As an optical sensor, a spectrometer that detects light by spectrally separating it according to its wavelength (i.e., detecting the spectral characteristics of light) may be used. In this case, by using a single-mode optical fiber as the optical transmission material, the spectral characteristics of the light transmitted from the tip of the optical irradiation device can be detected more accurately by the spectrometer. However, it is also possible to use optical sensors other than spectrometers (e.g., photodiodes). Furthermore, it is also possible to use a multimode fiber as the optical transmission material while detecting the spectral characteristics of the light with a spectrometer. 【0033】 The optical transmission member may be placed inside the hollow rotational transmission member. In the optical irradiation device of this disclosure, a conductor is placed outside the rotational transmission member. Therefore, if the optical transmission member is also placed outside the rotational transmission member, the external configuration of the rotational transmission member becomes complex, and it becomes difficult to reduce the diameter of the optical irradiation device. In contrast, by placing the optical transmission member inside the rotational transmission member, the configuration of the optical irradiation device is simplified and the diameter is reduced. Furthermore, the optical transmission member is less prone to unnecessary deformation than a conductor and is easier to handle. Therefore, workers manufacturing the optical irradiation device can easily and appropriately pass the optical transmission member inside the rotational transmission member. 【0034】 However, it is also possible to place the optical transmission member on the outside of the rotation transmission member. In this case, for example, when passing the coolant through the hollow portion of the rotation transmission member, it becomes easier for the coolant to flow smoothly to the tip, among other benefits. 【0035】A second aspect of the light irradiation device of the present disclosure is a long, slender medical light irradiation device comprising a rotational transmission member, a laser light emitter, a light sensor, and a conductor. The rotational transmission member is long and hollow. The rotational transmission member transmits rotation between its base and tip ends. The laser light emitter emits laser light from the tip end of the long device body. The light sensor is positioned at the tip end of the device body to detect light. The conductor extends along the rotational transmission member from the base end to the tip end and is electrically connected to the light sensor. The conductor is positioned outside the hollow rotational transmission member. 【0036】 According to a second embodiment of the light irradiation device of this disclosure, the conductor connected to the optical sensor at the tip is arranged on the outside of the hollow portion of the rotational transmission member, rather than inside. When the conductor is arranged in the hollow portion of the rotational transmission member, it is essential to secure space for the conductor in the hollow portion of the rotational transmission member. In contrast, when the conductor is arranged on the outside of the rotational transmission member, it is not necessary to secure space for the conductor in the hollow portion, making it easier to freely select the diameter of the rotational transmission member used in the light irradiation device. Therefore, it becomes easier to miniaturize the light irradiation device (for example, make it thinner) by reducing the area of ​​the portion surrounded by the outermost surface of the light irradiation device when viewed in a cross-section intersecting the extension direction. Furthermore, since the diameter of the rotational transmission member to be used can be easily selected, it also becomes easier to adjust the flexibility of the light irradiation device (i.e., flexibility in the direction intersecting the extension direction of the device) which changes according to the diameter of the rotational transmission member, etc. Therefore, insertion and manipulation of the light irradiation device into a living organism becomes easier. As described above, the light irradiation device of this disclosure makes it possible to appropriately achieve both miniaturization and flexibility adjustment while providing a light sensor, which is a component that requires the connection of a wire, at the tip. 【0037】A second aspect of this disclosure illustrates a case where the core at the leading edge of the optical fiber is the laser light emitter. In this case, the optical fiber extends from the base end to the tip end of the optical irradiation device. A laser light source that emits laser light is located at the base end of the optical irradiation device. The optical fiber guides the laser light emitted from the laser light source to the tip end of the optical irradiation device and emits the laser light from the laser light emitter, which is the leading edge. In the second aspect of this disclosure, the optical fiber is inserted into the hollow portion of the rotational transmission member. However, the optical fiber may be located outside the rotational transmission member. 【0038】 However, the laser light emission unit may be the laser light emission unit of the laser light source used in the first embodiment described above. In this case, the wire connected to the laser light source at the tip and the wire connected to the optical sensor may both be located outside the rotation transmission member. 【0039】 Furthermore, at least one of the various configurations of the light irradiation device according to the first embodiment described above can also be applied to the light irradiation device according to the second embodiment. For example, the hollow portion of the rotational transmission member may be used as a coolant flow path. The coolant that has passed through the hollow portion of the rotational transmission member may be discharged further toward the tip from the open end of the tip of the rotational transmission member. The light irradiation device may further comprise the rotational transmission member and a covering layer that covers the outer circumference of a conductor arranged outside the rotational transmission member. The conductor may also be arranged outside the covering layer that covers the outer circumference of the rotational transmission member. The conductor may be an insulated coated conductor or a flexible substrate, and may construct two or more transmission lines to the light sensor. When the shape of the conductor is viewed in a cross-section intersecting the axis of the rotational transmission member, the width of the conductor in the circumferential direction of the axis may be greater than the thickness of the conductor. The light irradiation device may further comprise a support that supports the light sensor. The support and the rotational transmission member may be fixed together. The light irradiation device may further comprise an intermediate member that joins the support and the rotational transmission member to each other. At least a part of the intermediate member may be formed of a material that is radiopaque. 【0040】A first aspect of the light irradiation system of the present disclosure is a medical light irradiation system comprising a catheter formed in the shape of a long tube and a long light irradiation device inserted into the lumen of the catheter. The light irradiation device comprises a rotational transmission member, a laser light source, and a conductor. The rotational transmission member is elongated and hollow. The rotational transmission member transmits rotation between its proximal and distal ends. The laser light source is connected to the rotational transmission member at the distal end of the elongated device body. The laser light source emits laser light from the distal end of the device body. The conductor extends along the rotational transmission member from the proximal end to the distal end and is electrically connected to the laser light source. The conductor is positioned outside the hollow rotational transmission member. 【0041】 According to a first aspect of the light irradiation system of this disclosure, the conductor connected to the laser light source at the tip of the light irradiation device is arranged outside the hollow portion of the rotational transmission member, rather than inside it. When the conductor is arranged in the hollow portion of the rotational transmission member, it is essential to secure space for the conductor in that portion. In contrast, when the conductor is arranged outside the rotational transmission member, it is not necessary to secure space for the conductor in the hollow portion, making it easier to freely select the diameter of the rotational transmission member used in the light irradiation device. Consequently, it becomes easier to miniaturize (thin) the light irradiation device by reducing the area of ​​the portion surrounded by the outermost surface of the light irradiation device when viewed in a cross-section intersecting the extension direction. Furthermore, since the diameter of the rotational transmission member to be used can be easily selected, it becomes easier to adjust the flexibility of the light irradiation device (i.e., the flexibility in the direction intersecting the extension direction of the device) which changes according to the diameter of the rotational transmission member, etc. Thus, insertion and operation of the light irradiation system into a living organism become easier. As described above, the light irradiation system of this disclosure makes it possible to appropriately achieve both miniaturization and flexibility adjustment while providing a laser light source, which is a component that requires the connection of a wire, at the tip. 【0042】At least a part of the distal end portion of the catheter may be formed with a discharge port for discharging the coolant from the inside of the catheter to the outside. In this case, the coolant passes near the laser light source and is discharged to the outside from the discharge port of the catheter. As a result, since the coolant continues to be supplied near the laser light source, it becomes easier to appropriately suppress the temperature rise of the laser light source and its vicinity. Also, the possibility that the blood outside the catheter contacts the laser light source is appropriately reduced. 【0043】 As described above, the coolant may be flowed through the hollow portion in the rotary transmission member of the light irradiation device. Also, the coolant may be flowed through the space between the lumen of the catheter and the light irradiation system. 【0044】 The specific form of the discharge port can be appropriately selected. For example, a passage hole for passing a guide wire may be provided at the distal end portion of the catheter. The passage hole for the guide wire may also serve as a discharge port for the coolant. Also, separately from the passage hole for the guide wire, a discharge port for the coolant may be formed at the distal end portion of the catheter. 【0045】 A discharge valve may be provided at the discharge port of the catheter to allow the discharge of the liquid to the outside of the catheter through the discharge port while preventing the inflow of the liquid from the outside to the inside of the catheter. In this case, the inflow of blood or the like outside the catheter into the inside of the catheter through the discharge port is suppressed by the discharge valve. As a result, the possibility that the blood contacts the laser light source is further reduced. 【0046】A second aspect of the light irradiation system of the present disclosure is a medical light irradiation system, which includes a catheter formed in a long tubular shape and a long light irradiation device inserted into the lumen of the catheter. The light irradiation device includes a rotational transmission member, a laser light emitting portion, an optical sensor, and a conducting wire. The outer shape of the rotational transmission member is long and hollow. The rotational transmission member transmits rotation between the proximal end side and the distal end side. The laser light emitting portion emits laser light from the distal end portion of the long device body. The optical sensor is disposed at the distal end portion of the device body to detect light. The conducting wire extends from the proximal end side to the distal end side along the rotational transmission member and is electrically connected to the optical sensor. The conducting wire is disposed outside the hollow rotational transmission member. 【0047】 According to the second aspect of the light irradiation system of the present disclosure, the conducting wire connected to the optical sensor at the distal end portion of the light irradiation device is disposed outside rather than inside the hollow portion of the rotational transmission member. When disposing the conducting wire in the hollow portion of the rotational transmission member, it is essential to secure a space for disposing the conducting wire in the hollow portion of the rotational transmission member. In contrast, when disposing the conducting wire outside the rotational transmission member, there is no need to secure a space for disposing the conducting wire in the hollow portion, so it becomes easier to freely select the diameter of the rotational transmission member to be adopted in the light irradiation device. Therefore, it also becomes easy to reduce the area of the portion surrounded by the outermost surface of the light irradiation device when viewed in a cross section intersecting the extension direction, and to miniaturize (for example, make thinner) the light irradiation device. Furthermore, since the diameter of the rotational transmission member to be adopted can be easily selected, it also becomes easy to adjust the flexibility of the light irradiation device (that is, the flexibility in the direction intersecting the extension direction of the device) that varies according to the diameter of the rotational transmission member and the like. Thus, the insertion and operation of the light irradiation system into the living body become easier. As described above, according to the light irradiation system of the present disclosure, while providing the optical sensor, which is a member that requires connection of a conducting wire, at the distal end portion, it is possible to appropriately achieve both reduction in diameter and adjustment of flexibility. Note that at least any one of the various configurations of the light irradiation system of the first aspect described above can also be applied to the light irradiation system of the second aspect. 【0048】This is a longitudinal cross-sectional view of the light irradiation system 1 with the light irradiation device 2 and catheter 3 separated. This is a longitudinal cross-sectional view of the light irradiation system 1 with the light irradiation device 2 attached to the catheter 3 (in use). This is an enlarged longitudinal cross-sectional view of the vicinity of the tip of the light irradiation system 1 in Figure 2. This is a perspective view of the vicinity of the tip of the light irradiation device 2. This is a cross-sectional view in the direction of the line A-A in Figure 3. This is a cross-sectional view of the first modified light irradiation device 2 taken at a cross-section intersecting the device body 210 with respect to its axis. This is a perspective view of the vicinity of the tip of the light irradiation device 2 in the second modified light irradiation device 2. This is a perspective view of the vicinity of the tip of the light irradiation device 2 in the third modified light irradiation device 2. 【0049】 Typical embodiments of this disclosure will be described below with reference to the drawings. The light irradiation system 1 of this embodiment is used by being inserted into a lumen of a living organism (for example, at least one of a blood vessel, lymph gland, urethra, airway, digestive organ, secretory gland, and reproductive organ). While inserted into a lumen of a living organism, the light irradiation system 1 irradiates living tissue with light (laser light in this embodiment). The light irradiation system can be used for at least one of therapies such as PDT (Photodynamic Therapy) and NIR-PIT (Near-infrared photoimmunotherapy). 【0050】 The light irradiation system 1 of this embodiment comprises a light irradiation device 2 and a catheter 3. When using the light irradiation system 1, the catheter 3 is first inserted into the lumen of the living body. Next, the light irradiation device 2 is inserted into the lumen 311 of the catheter 3, which is shaped like a long tube. Once insertion is complete, light is irradiated onto the living tissue from the light irradiation device 2. However, it is also possible to use only the light irradiation device 2 without using the catheter 3. 【0051】Figures 1 to 3 illustrate mutually orthogonal X and Y axes. In these figures, the lower side of the figure (+X direction) is referred to as the "tip side," the upper side of the figure (-X direction) as the "proximal side," the left side of the figure (+Y direction) as the "left side," and the right side of the figure (-Y direction) as the "right side." The light irradiation system 1, light irradiation device 2, and catheter 3 are inserted into the biological lumen from the tip side. The proximal side is operated by a medical professional (e.g., a physician). 【0052】 (Light Irradiation Device) The light irradiation device 2 of this embodiment will be described with reference to Figures 1 to 5. As shown in Figures 1 and 2, the light irradiation device 2 has an elongated shape. The light irradiation device 2 comprises a connector 201, a device body 210, and a laser light source 11. The connector 201 is located on the base end side of the light irradiation device 2 and is held by the operator. The connector 201 comprises a pair of wing portions 202 and a connecting portion 203. The connecting portion 203 is a substantially cylindrical member. The wing portions 202 are connected to the base end of the connecting portion 203. The device body 210 is connected to the tip of the connecting portion 203. The wing portions 202 and the connecting portion 203 may be formed integrally. The device body 210 is an elongated member. Details will be described later, but the device body 210 comprises a rotation transmission member 20 and conductors 14A and 14B. The laser light source 11 is a small laser light source that emits laser light in a predetermined wavelength range. The laser light source 11 is provided at the tip of the elongated device body 210. 【0053】The laser light source 11 has, for example, a semiconductor laser element. When the semiconductor laser element is used as an ultraviolet laser, violet laser, blue laser, and green laser, GaN-based materials such as GaN, InGaN, and AlGaN are used. When the semiconductor laser element is used as a red laser, infrared laser, and near-infrared laser, GaAs-based materials such as GaAs and AlGaAs, or InP-based materials such as InAlGaP and GaInP are used. The width of the ridge may be designed to be, for example, 2 μm to 100 μm. The transverse mode may be multimode or single-mode. Also, there is no need to have only one ridge; there may be multiple ridges. By having multiple ridges, heat can be dispersed, thus improving heat dissipation. 【0054】 The semiconductor laser element may be an end-face emitting laser element that irradiates laser light in a direction horizontal to the substrate, or a vertical cavity surface emitting laser element (VCSEL) that irradiates laser light in a direction perpendicular to the substrate. By using a vertical cavity surface emitting laser element, the light irradiation device 2 can emit laser light with less power than an end-face emitting laser element and also has high resistance to temperature changes. Furthermore, since the surface emitting laser can emit laser light in a direction perpendicular to the substrate surface, there is no need to use a mirror 13, and the irradiation position of the laser light can be adjusted more accurately. Note that a vertical cavity surface emitting laser element may be used in combination with one or more of the mirrors, prisms, lenses, and diffractive optical elements that change the divergence angle of the light emitted from the light emission part. 【0055】By using the laser light source 11, it is possible to selectively irradiate specific locations in the living body with light of a specific wavelength. As a result, various problems (e.g., side effects) caused by light being irradiated to unintended locations are less likely to occur. Furthermore, the laser light source 11 has the property of being able to irradiate light of wavelengths with a narrower spectral width than light-emitting diodes. Therefore, by using the laser light source 11, the occurrence of various problems (e.g., at least one of the following, such as a decrease in irradiation efficiency and unintended tissue changes) caused by irradiating tissue with wavelengths different from those necessary for treatment (e.g., the excitation wavelength of photosensitive substances) is also suppressed. Thus, it becomes easier to irradiate specific locations within the lumen of the living body more efficiently and appropriately. 【0056】 As shown in Figures 3 and 4, a support 12, a mirror 13, conductors 14A and 14B, and a sealing member 16 (see Figure 3) are provided near the laser light source 11. In Figure 4, the sealing member 16 (see Figure 3) and the coating layer 30 (see Figure 3), which will be described later, are omitted from the illustration for ease of understanding the configuration. The support 12 supports the laser light source 11 and the mirror 13. The mirror 13 can be made of silicon (Si), resin material, glass material, or metal material, and may have a reflective layer of metal and / or dielectric multilayer film as its reflective surface. The support 12 can be made of silicon (Si), aluminum nitride (AlN), silicon nitride (SiN), diamond, sapphire (Al ２ O ３ It is formed from insulating materials such as glass, quartz, alumina, or ceramics, or from metals such as copper. As shown in Figure 3, in this embodiment, the laser light source 11 and the mirror 13 are mounted on the surface of the support 12 facing the +Y direction. A conductive layer 124 is formed on the support 12 from the mounting surface of the laser light source 11 facing the +Y direction, through the side, to the back surface (the surface facing the -Y direction). 【0057】The tip surface of the laser light source 11, supported by the support 12, becomes the light emission section 111 from which the laser light is emitted. The reflective surface of the mirror 13 is inclined (inclined at 45 degrees in this embodiment) with respect to the optical axis of the laser light emitted from the light emission section 111. As a result, the laser light emitted from the light emission section 111 of the laser light source 11 is reflected by the reflective surface of the mirror 13 and irradiated in a Loot direction that intersects the axial direction of the light irradiation device 2 (in this embodiment, a direction that intersects perpendicularly to the axial direction of the light irradiation device 2). The mirror 13 may be provided with at least one of a reflective layer made of metal and a dielectric multilayer film. In this case, the light reflection efficiency is improved. 【0058】 The conductors 14A and 14B extend along the device body 210 from the base end to the tip end and are electrically connected to the laser light source 11. The base ends of the conductors 14A and 14B are connected to a control unit 5 that controls the light irradiation device 2. In this embodiment, the conductor 14A is electrically connected to the first electrode of the pair of electrodes of the laser light source 11 by being joined to the first electrode. The conductor 14B is joined to a conductive layer 124 formed on the support 12. The conductive layer 124 is electrically connected to a second electrode of the pair of electrodes of the laser light source 11, which is different from the first electrode. As a result, the conductor 14B is electrically connected to the second electrode of the laser light source 11. As shown in Figure 3, the conductors 14A and 14B are connected to the surface of the laser light source 11 facing the +Y direction and the surface of the support 12 facing the -Y direction, respectively, so as not to obstruct the irradiation of laser light from the laser light source 11. 【0059】In this embodiment, insulated coated wires are used as conductors 14A and 14B. Therefore, the shape of conductors 14A and 14B is appropriately deformed in accordance with changes in the shape of the device body 210 of the light irradiation device 2. As an example, rectangular insulated coated wires are used for conductors 14A and 14B in this embodiment. As a result, the contact area of ​​conductors 14A and 14B with the laser light source 11 and the conductive layer 124 is appropriately secured. Furthermore, compared to the case where round insulated coated wires are used, it becomes easier to reduce the diameter of the light irradiation device 2. In this embodiment, conductors 14A and 14B are formed by insulatingly coating metal wiring made of good conductors such as Cu and Ni with polyurethane, which is an insulating coating. In other words, both conductors 14A and 14B in this embodiment are insulated wires. Note that instead of polyurethane, the metal wiring may be insulatingly coated with an insulating resin such as polyester, polyesterimide, polyamideimide, or polyimide. Furthermore, the conductors 14A and 14B form two or more transmission lines to the laser light source 11 (lines that transmit at least one of the power supply and / or signals to the laser light source 11). As a result, the light irradiation device 2 is driven appropriately. When signals are transmitted by the conductors 14A and 14B, for example, at least one of the drive signals for driving the laser light source 11 and signals output from electronic components of the laser light source 11 (e.g., a light sensor or a temperature sensor) may be transmitted by the conductors 14A and 14B. 【0060】 However, the configuration of the conductors 14A and 14B can be changed. For example, a flexible printed circuit board (FPC board) may be used as the conductor. In this case as well, the shape of the conductor will be appropriately deformed according to the change in the shape of the device body 210 of the light irradiation device 2. A flexible circuit board equipped with multiple transmission lines (for example, a positive transmission line and a negative transmission line) may be used as the conductor. In this case, the number of conductors can be reduced, making it easier to reduce the amount of work required when manufacturing the light irradiation device 2. 【0061】The sealing member 16 prevents liquid from flowing into the laser light source 11 by sealing the laser light source 11 inside. Furthermore, the sealing member 16 ensures the insulation of the laser light source 11. For example, the sealing member 16 can be made of an organic material such as a resin material, or an inorganic material. It is desirable that the sealing member 16 has antithrombotic properties, flexibility, thermal conductivity, and biocompatibility. For example, the resin material can be polyamide resin, polyimide resin, polyolefin resin, polyester resin, polyurethane resin, polycarbonate resin, polyethylene terephthalate resin, silicone resin, epoxy resin, acrylic resin, and fluororesin. For the inorganic material, for example, a coating obtained by applying a polysilazane solution and silicating it (hereinafter referred to as "polysilazane coating") can be used. A resin layer made of the aforementioned resin material may be provided on the surface of the polysilazane coating. At least the portion of the sealing member 16 located in the path of the laser light (in this embodiment, the entire sealing member 16) is made of a light-transmitting material. 【0062】 As shown in Figures 3 and 4, the device body 210 comprises conductors 14A and 14B and a rotation transmission member 20. The rotation transmission member 20 is elongated and hollow. The rotation transmission member 20 transmits rotation (torque) between its base end and tip end. In this embodiment, a torque coil (multi-layer coil) is used for the rotation transmission member 20. However, it is also possible to use a hollow rotation transmission member other than a torque coil. The laser light source 11 is connected to the rotation transmission member 20 at the tip of the elongated device body 210. 【0063】In the light irradiation device 2 of this embodiment, the conductors 14A and 14B connected to the laser light source 11 at the tip are arranged on the outside of the hollow portion 21 of the rotation transmission member 20, rather than inside. When the conductors 14A and 14B are arranged in the hollow portion 21 of the rotation transmission member 20, it is essential to secure space for the conductors 14A and 14B in the hollow portion 21 of the rotation transmission member 20. In contrast, when the conductors 14A and 14B are arranged on the outside of the rotation transmission member 20, it is not necessary to secure space for the conductors 14A and 14B in the hollow portion 21, making it easier to freely select the diameter of the rotation transmission member 20 used in the light irradiation device 2. Consequently, it becomes easier to miniaturize (thin) the light irradiation device 2 by reducing the area of ​​the portion surrounded by the outermost surface of the light irradiation device 2 when viewed in a cross-section intersecting the extension direction (axial direction of the rotation transmission member 20). Furthermore, since the diameter of the rotational transmission member 20 to be used can be easily selected, it becomes easy to adjust the flexibility of the light irradiation device 2 (i.e., flexibility in the direction intersecting the extension direction of the device), which changes according to the diameter of the rotational transmission member 20. Therefore, insertion and manipulation of the light irradiation device 2 into a living body becomes easier. Note that the conductors 14A and 14B are often easily deformed and difficult to handle, so it is often difficult to place the conductors 14A and 14B in the hollow portion 21 of the rotational transmission member 20. In contrast, by placing the conductors 14A and 14B on the outside of the rotational transmission member 20, the workability when manufacturing the light irradiation device 2 is easily improved. 【0064】 The hollow portion 21 of the rotational transmission member 20 serves as a coolant flow path that allows the coolant to pass from the base end to the laser light source 11. As described above, in the light irradiation device 2 of this embodiment, the conductors 14A and 14B are not arranged in the hollow portion 21 of the rotational transmission member 20, so the hollow portion 21 can be used as a coolant flow path. By flowing coolant through the hollow portion 21 of the rotational transmission member 20, the heat dissipation of the laser light source 11 is ensured, and the insertion and operation of the light irradiation device 2 into the body becomes easier. In other words, ensuring the heat dissipation of the laser light source 11 and improving the operability of the device are appropriately achieved. Various liquids that do not affect biological tissue (for example, physiological saline) can be used as the coolant. 【0065】 More specifically, as shown in Figures 3 and 4, the tip of the rotation transmission member 20 has an open end 22 that opens the hollow portion 21 to the outside (tip side). The coolant that has passed through the hollow portion 21 of the rotation transmission member 20 is discharged from the open end 22 toward the laser light source 11. As a result, the coolant flows appropriately toward the laser light source 11, making it easier for the laser light source 11 to be cooled more effectively. 【0066】 As shown in Figures 3 and 5, the light irradiation device 2 of this embodiment includes a coating layer 30. The coating layer 30 tightly covers the rotation transmission member 20 and the outer circumference of the conductors 14A and 14B arranged outside the rotation transmission member 20. As an example, the coating layer 30 of this embodiment employs a heat-shrinkable tube that shrinks to tightly adhere to the outside of the rotation transmission member 20 and the conductors 14A and 14B when heat is applied while covering the rotation transmission member 20 and the outer circumference of the conductors 14A and 14B arranged outside the rotation transmission member 20. With the coating layer 30 in place, leakage of fluid (e.g., coolant) from the rotation transmission member 20 to the outside and intrusion of fluid from the outside into the rotation transmission member 20 are prevented, and the position of the conductors 14A and 14B outside the rotation transmission member 20 is appropriately maintained. Furthermore, when coolant is flowed through the hollow portion 21 of the rotation transmission member 20, the coating layer 30 is not interposed between the rotation transmission member 20 and the conductors 14A and 14B. Therefore, the conductors 14A and 14B are also more easily cooled by the coolant passing through the hollow portion 21 of the rotation transmission member 20. Since the conductors 14A and 14B are connected to the laser light source 11, the cooling of the conductors 14A and 14B makes it easier for the heat from the laser light source 11 to be released into the coolant through the conductors 14A and 14B. Thus, both ensuring the heat dissipation of the laser light source 11 and improving the operability of the device are more appropriately achieved. 【0067】In addition, the conductors 14A and 14B are often easily deformed and difficult to handle. However, during the manufacturing of the light irradiation device 2 of this embodiment, the conductors 14A and 14B are temporarily fixed to the outside of the rotation transmission member 20 with adhesive, and the coating layer 30 is placed on the outer circumference of the rotation transmission member 20 and the conductors 14A and 14B. As a result, workability is improved. Furthermore, in this embodiment, the thermal conductivity of the rotation transmission member 20 is approximately 16.3 W / m·K, the thermal conductivity of the conductors 14A and 14B is approximately 236 to 372 W / m·K, the thermal conductivity of the adhesive is approximately 0.13 to 0.25 W / m·K, and the thermal conductivity of the coating layer 30 is approximately 0.17 W / m·K or less. Therefore, the heat from the laser light source 11 is properly released into the coolant through the conductors 14A and 14B. 【0068】 Figure 5 is a cross-sectional view taken along the line A-A in Figure 3. As shown in Figure 5, when examining the shape of the conductors 14A and 14B in a cross-section intersecting the axis O of the rotation transmission member 20, the width W of the conductors 14A and 14B in the circumferential direction of the axis O is greater than the thickness T of the conductors 14A and 14B. Therefore, it becomes easier to minimize the thickness T of the conductors 14A and 14B, and thus easier to reduce the overall diameter of the light irradiation device 2. In addition, it becomes easier to secure the contact area between the rotation transmission member 20 and the conductors 14A and 14B, so the holding state of the conductors 14A and 14B on the outside of the rotation transmission member 20 becomes more stable. 【0069】 As shown in Figure 4, the laser light source 11 in this embodiment is supported by a support 12. The support 12 and the rotation transmission member 20 are fixed (connected). As a result, the relative positional relationship between the tip of the rotation transmission member 20 and the laser light source 11 is stabilized. Therefore, the operability of the light irradiation device 2 is further improved. Furthermore, the flow of the cooling liquid supplied to the laser light source 11 through the hollow portion 21 is also stabilized, so the laser light source 11 is cooled more effectively. 【0070】As shown in Figure 4, an intermediate member 40 is provided between the support 12 and the rotation transmission member 20. The intermediate member 40 interposes itself between the support 12 and the rotation transmission member 20, thereby fixing the support 12 and the rotation transmission member 20 to each other. By using the intermediate member 40, the degree of freedom in fixing is improved compared to when the support 12 and the rotation transmission member 20 are directly joined, making it easier to fix the support 12 and the rotation transmission member 20 more appropriately. The material of the intermediate member 40 can be at least one of various materials such as resin (adhesive may also be used) and metal members. In detail, in this embodiment, at least a part (the whole in this embodiment) of the intermediate member 40 is made of a material that is radiopaque. Therefore, when a medical professional (e.g., a surgeon) irradiates biological tissue with laser light using the light irradiation device 2 while taking images of the inside of the body using radiation, they can appropriately adjust the irradiation position of the laser light by checking the position of the intermediate member 40 that appears in the captured image. Thus, the accuracy of treatment is more easily improved. 【0071】 (Catheter) The catheter 3 of this embodiment will be described with reference to Figures 1 to 3. As shown in Figures 1 and 2, the catheter 3 has the shape of a long tube. The catheter 3 comprises a connector 301, a shaft 310, and a tip 320. The connector 301 is located on the proximal end side of the catheter 3 and is grasped by the operator. The connector 301 comprises a pair of wing portions 302 and a connecting portion 303. The connecting portion 303 is a substantially cylindrical member. The wing portions 302 are connected to the proximal end of the connecting portion 303. The shaft 310 is connected to the tip of the connecting portion 303. The wing portions 302 and the connecting portion 303 may be formed integrally. 【0072】The shaft 310, like the device body 210 of the light irradiation device 2, is preferably antithrombotic, flexible, and biocompatible. The shaft 310 is a long, tubular member extending along the axis O3 (see Figure 1). In this embodiment, the shaft 310 is formed in a hollow cylindrical shape with both the tip and proximal ends open. The lumen 311 inside the shaft 310 functions as a guidewire lumen for positioning the catheter 3 by passing a guidewire through the lumen 311 of the catheter 3 during catheter delivery. After the catheter 3 has been delivered, the lumen 311 functions as a device lumen for positioning the light irradiation device 2 relative to the catheter 3. 【0073】 The tip 320 is connected to the tip of the shaft 310. The tip 320 has an outer shape that narrows in diameter from the proximal end to the tip end in order to allow the catheter 3 to advance smoothly within the lumen of the body. A through hole 321 is formed approximately in the center of the tip 320, penetrating in the direction of the axis O3. The inner diameter of the through hole 321 is smaller than the inner diameter of the lumen 311 of the shaft 310 and also smaller than the outer diameter of the tip portion of the light irradiation device 2. Furthermore, the outer diameter of the device body 210 and the tip portion of the light irradiation device 2 is less than or equal to the inner diameter of the lumen 311 of the catheter 3. At least a portion of the tip 320 (in this embodiment, the entire tip 320) is made of a radiopaque material. Therefore, the position of the tip portion of the catheter 3 can be appropriately determined by imaging using radiation. 【0074】 In this embodiment, cooling liquid is supplied not only to the hollow portion 21 of the rotation transmission member 20 in the light irradiation device 2, but also to the lumen 311 of the catheter 3 (the space between the outer surface of the light irradiation device 2 and the inner surface of the lumen 311 of the catheter 3). As a result, malfunctions caused by temperature rise due to the laser light source 11 are further suppressed. 【0075】As shown in Figure 3, the tip side surface (or, in this embodiment, a part of the tip side surface) of the shaft 310 of the catheter 3 is provided with a light-transmitting section 330 that allows laser light emitted by the laser light source 11 of the light irradiation device 2 (in this embodiment, laser light reflected by the mirror 13) to pass to the outside. Therefore, the light irradiation system 1 of this embodiment is capable of selectively irradiating a specific location on a living body with laser light emitted by the laser light source 11 of the light irradiation device 2 in a direction intersecting the axis O3. 【0076】 The shaft 310 of the catheter 3 is provided with a radiopaque catheter-side marker portion 332 located close to the light-transmitting portion 330. Therefore, when medical professionals use radiation to image the inside of a living body and irradiate living tissue with laser light using the light irradiation device 2, they can align the position of the laser light source 11 of the light irradiation device 2 with the position of the catheter-side marker portion 332 that appears in the captured image, thereby appropriately irradiating the laser light from the light-transmitting portion 330 to the outside. This makes it easier to further improve the accuracy of treatment. 【0077】 As shown in Figure 3, the tip of the catheter 3 has an outlet 341 that discharges the cooling liquid from inside the lumen 311 to the outside of the catheter 3. Therefore, the cooling liquid supplied to the inside of the catheter 3 (in this embodiment, both the cooling liquid supplied to the hollow portion 21 of the rotation transmission member 20 of the light irradiation device 2 and the cooling liquid supplied to the lumen 311 of the catheter 3) passes near the tip of the light irradiation device 2 where the laser light source 11 is installed and is discharged to the outside of the catheter 3 from the outlet 341. As a result, the cooling liquid is continuously supplied to the vicinity of the laser light source 11, making it easier to suppress the temperature rise of the laser light source 11 and its vicinity. In addition, the possibility of blood outside the catheter 3 coming into contact with internal components of the catheter 3 (for example, the laser light source 11) is also appropriately reduced. Therefore, blood coagulation due to the heat of the laser light source 11 is less likely to occur. 【0078】In this embodiment, the catheter 3 has a through-hole 321 in the tip 320 through which the guidewire passes during catheter delivery, which also serves as a cooling fluid outlet 341. Therefore, both catheter delivery and cooling near the laser light source 11 are performed appropriately while keeping the catheter 3's configuration simple. However, it is also possible to change the specific configuration of the catheter outlet. For example, the outlet may be formed on the side of the elongated tubular shaft 310, either separately from or together with the through-hole 321 in the tip 320. It is desirable that the outlet be formed further towards the tip of the catheter 3 in the extension direction, beyond the position where the laser light source 11 is positioned during use. 【0079】 As shown in Figure 3, the outlet 341 of the catheter 3 is provided with an outlet valve 322 that allows liquid to be discharged to the outside of the catheter 3 through the outlet 341, while preventing liquid from flowing in from the outside to the inside of the catheter 3. As a result, the outlet valve 322 prevents blood and other fluids from the outside of the catheter 3 from flowing into the inside of the catheter 3 through the outlet 341. 【0080】(Modifications) The technology disclosed in the above embodiments is merely an example. Therefore, it is possible to modify the technology illustrated in the above embodiments. Referring to Figure 6, a first modification of the above embodiment will be described. Figure 6 is a cross-sectional view of the device body 210 of the light irradiation device 2 of the first modification, viewed in a cross section intersecting the axis O. The light irradiation device 2 of the first modification shown in Figure 6 includes a coating layer 31. The coating layer 31 shown in Figure 6 covers the outer circumference of the rotation transmission member 20. As an example, the coating layer 31 shown in Figure 6 employs a heat-shrinkable tube that has been heated while covering the outer circumference of the rotation transmission member 20, causing it to shrink to adhere closely to the outside of the rotation transmission member 20. The conductors 14A and 14B are arranged outside the coating layer 31 that covers the outer circumference of the rotation transmission member 20. In other words, since the coating layer 31 is interposed between the rotation transmission member 20 and the conductors 14A and 14B, the temperature of the coolant is less likely to rise due to the heat conducted to the conductors 14A and 14B. As a result, the coolant is more likely to reach the vicinity of the laser light source 11 while remaining at a lower temperature. Therefore, the laser light source 11 is more easily cooled. The conductors 14A and 14B can be fixed to the outside of the coating layer 31 with various materials such as adhesives. 【0081】 A second modified example of the above embodiment will be described with reference to Figure 7. Figure 7 is a perspective view of the vicinity of the tip of the light irradiation device 2 of the second modified example. Some of the configurations in the second modified example described below can be the same as those in the above embodiment. Therefore, for parts of the configuration of the second modified example that can be the same as those in the above embodiment, the same reference numerals as in the above embodiment will be used, and their detailed descriptions will be omitted or simplified. 【0082】As shown in Figure 7, the device body 210 of the second modified optical irradiation device 2 includes a laser light source 11, a rotation transmission member 20, and conductors 14A, 14B, etc., similar to the device body 210 of the above embodiment. The conductors 14A and 14B are arranged on the outside of the hollow portion 21 of the rotation transmission member 20, rather than inside. Furthermore, the optical irradiation device 2 of the second modified embodiment includes an optical transmission member 60 and an optical sensor 70. The optical transmission member 60 is elongated and receives light from the tip of the device body 210 from which laser light is emitted by the laser light source 11, and transmits the incident light to the optical sensor 70. The optical sensor 70 is installed on the base end side of the elongated device body 210 in the optical irradiation device 2 and detects the light transmitted by the optical transmission member 60. 【0083】 In the second modified example of the light irradiation device 2, it is not necessary to install a light sensor at the tip of the light irradiation device 2. Therefore, the state of light at the tip of the light irradiation device 2 can be appropriately detected by the light sensor 70 while simplifying and miniaturizing the configuration of the tip of the light irradiation device 2. The light transmission member 60 may transmit laser light emitted from the laser light source 11 to the light sensor 70. In this case, the tip of the light transmission member 60 may face the upstream side of the laser light path. Alternatively, the light transmission member 60 may transmit light from the tissue irradiated with laser light to the light sensor 70. In this case, the tip of the light transmission member 60 may face the downstream side of the laser light path (i.e., the side of the tissue irradiated with laser light). 【0084】The optical transmission member 60 used in the optical irradiation device 2 of the second modified example is a single-mode optical fiber. In a single-mode optical fiber, the propagation mode is limited to one by reducing the core diameter, and the phase of the propagated light is less likely to change. Therefore, by using a single-mode optical fiber as the optical transmission member 60, the state of light at the tip of the optical irradiation device 2 can be more accurately detected by the optical sensor 70 provided at the base end. Also, since single-mode optical fibers have a smaller core diameter than multi-mode optical fibers, they are often unsuitable for transmitting laser light for treatment, etc., which have a high light irradiation density. However, since the light irradiation density of the detection light transmitted to the optical sensor 70 is lower than that of the laser light for treatment, the detection light is appropriately transmitted to the optical sensor 70 by the single-mode optical fiber. However, it is also possible to use a multi-mode optical fiber as the optical transmission member. 【0085】 The optical sensor 70 used in the second modified optical irradiation device 2 is a spectrometer that detects light by spectrally separating it according to its wavelength (i.e., it detects the spectral characteristics of light). Therefore, by using a single-mode optical fiber as the optical transmission member 60, the spectral characteristics of the light transmitted from the tip of the optical irradiation device 2 can be detected more accurately by the optical sensor 70. 【0086】 In the second modified example, the light irradiation device 2, the light transmission member 60 is positioned inside the hollow rotation transmission member 20. Therefore, the complexity of the external configuration of the device body 210 of the light irradiation device 2, where the conductors 14A, 14B, etc. are arranged, is suppressed, and the diameter of the device body 210 can be easily reduced. Furthermore, the light transmission member 60 is less prone to unnecessary deformation than the conductors 14A, 14B and is easier to handle. Therefore, workers manufacturing the light irradiation device 2 can easily and appropriately pass the light transmission member 60 inside the rotation transmission member 20. 【0087】A third modification of the above embodiment will be described with reference to Figure 8. Figure 8 is a perspective view of the vicinity of the tip of the light irradiation device 2 of the third modification. Some of the configurations in the third modification described below can be the same as those in the above embodiment. Therefore, for parts of the configuration of the third modification that can be the same as those in the above embodiment, the same reference numerals as in the above embodiment will be used, and their detailed descriptions will be omitted or simplified. 【0088】 As shown in Figure 8, the device body 210 of the third modified optical irradiation device 2 comprises a rotational transmission member 20, an optical fiber 80, a mirror 85, an optical sensor 90, and conductors 94A and 94B. The optical sensor 90 and the mirror 85 are fixed on a support (e.g., a submount) 89. The support 89 and the rotational transmission member 20 are fixed to each other by an intermediate member 40 similar to that of the above embodiment. 【0089】 The rotation transmission member 20 has an elongated shape and is hollow. The rotation transmission member 20 transmits rotation (torque) between its base end and tip end. The base end of the optical fiber 80 is connected to the laser light source 82. The optical fiber 80 transmits the laser light emitted by the laser light source 82 to the tip of the light irradiation device 2. Furthermore, the optical fiber 80 emits the transmitted laser light from the laser light emission section 81, which is the furthest tip surface located at the tip of the light irradiation device 2. 【0090】 The reflective surface 86 of the mirror 85 is inclined (inclined at 45 degrees in this embodiment) with respect to the optical axis of the laser beam emitted from the laser beam emission unit 81. As a result, the laser beam emitted from the laser beam emission unit 81 toward the tip is reflected by the reflective surface 86 of the mirror 85 and irradiated in a direction that intersects (intersects perpendicularly in Figure 8) the axial direction of the light irradiation device 2. 【0091】 In the example shown in Figure 8, the light sensor 90 is located on the tip side of the mirror 85. The light sensor 90 detects light at the tip of the light irradiation device 2. The conductors 94A and 94B extend along the device body 210 from the base end to the tip end and are electrically connected to the light sensor 90. The base ends of the conductors 94A and 94B are connected to a control unit that controls the light irradiation device 2. 【0092】 In the third modified light irradiation device 2, the conductors 94A and 94B connected to the optical sensor 90 at the tip are arranged on the outside of the hollow portion 21 of the rotational transmission member 20, rather than inside. When the conductors 94A and 94B are arranged in the hollow portion 21 of the rotational transmission member 20, it is essential to secure space for the conductors 94A and 94B in the hollow portion 21 of the rotational transmission member 20. In contrast, when the conductors 94A and 94B are arranged on the outside of the rotational transmission member 20, it is not necessary to secure space for the conductors 94A and 94B in the hollow portion 21, making it easier to freely select the diameter of the rotational transmission member 20 used in the light irradiation device 2. Consequently, it becomes easier to miniaturize the light irradiation device 2 (for example, make it thinner) by reducing the area of ​​the portion surrounded by the outermost surface of the light irradiation device 2 when viewed in a cross-section intersecting the extension direction (axial direction of the rotational transmission member 20). Furthermore, since the diameter of the rotational transmission member 20 to be used can be easily selected, it becomes easy to adjust the flexibility of the light irradiation device 2 (i.e., flexibility in the direction intersecting the extension direction of the device), which changes according to the diameter of the rotational transmission member 20. Therefore, insertion and manipulation of the light irradiation device 2 into a living body becomes easier. Note that the conductors 94A and 94B are often easily deformed and difficult to handle, so it is often difficult to place the conductors 94A and 94B in the hollow portion 21 of the rotational transmission member 20. In contrast, by placing the conductors 94A and 94B on the outside of the rotational transmission member 20, the workability when manufacturing the light irradiation device 2 is easily improved. 【0093】 In the third modified example, the optical irradiation device 2, the optical fiber 80 is arranged inside the hollow rotational transmission member 20. Therefore, the complexity of the external configuration of the device body 210 of the optical irradiation device 2, where the conductors 94A, 94B, etc. are arranged, is suppressed, and the diameter of the device body 210 can be easily reduced. Furthermore, the optical fiber 80 is less prone to unnecessary deformation than the conductors 94A, 94B and is easier to handle. Therefore, workers manufacturing the optical irradiation device 2 can easily and appropriately pass the optical fiber 80 inside the rotational transmission member 20. 【0094】Furthermore, the material of the optical fiber in the above embodiments and modified examples can be appropriately selected. For example, resin may be used as the material of the optical fiber. In other words, POF (Plastic Optical Fiber) may be used as the optical fiber. It is also possible to use a hollow fiber in the optical irradiation device 2. In addition, a single optical fiber may be used in the optical irradiation device 2, or a bundled fiber, which is made by bundling multiple strands of optical fiber, may be used in the optical irradiation device 2. The diameter of a single optical fiber, or the bundled fiber as a whole, may be, for example, 50 μm to 1 mm. 【0095】 It is also possible to adopt only some of the configurations exemplified in the above embodiments and modifications for a light irradiation system, light irradiation device, or catheter. As mentioned above, it is also possible to use only the light irradiation device 2 without using the catheter 3. 【0096】The technology relating to this disclosure can also be expressed as follows: (1) A light irradiation device for medical use that is elongated in shape, comprising: a hollow rotation transmission member having an elongated external shape and transmitting rotation between a base end and a tip end; a laser light source connected to the rotation transmission member at the tip of the elongated device body and emitting laser light; and a conductor extending from the base end to the tip end along the rotation transmission member and electrically connected to the laser light source, wherein the conductor is arranged on the outside of the hollow rotation transmission member. (2) The light irradiation device according to (1), wherein the hollow portion of the rotation transmission member becomes a coolant flow path that allows coolant to pass from the base end to the laser light source. (3) The light irradiation device according to (2), wherein an open end is formed at the tip of the rotation transmission member to open the hollow portion to the outside, and the coolant that has passed through the hollow portion of the rotation transmission member is discharged from the open end toward the laser light source. (4) A light irradiation device according to any one of (1) to (3), further comprising the rotation transmission member and a coating layer covering the outer circumference of the conductor disposed on the outside of the rotation transmission member. (5) A light irradiation device according to any one of (1) to (3), further comprising a coating layer covering the outer circumference of the rotation transmission member, wherein the conductor is disposed on the outside of the coating layer covering the outer circumference of the rotation transmission member. (6) A light irradiation device according to any one of (1) to (5), wherein the conductor is an insulated coated conductor or a flexible substrate having flexibility, and two or more transmission lines to the laser light source are constructed. (7) A light irradiation device according to any one of (1) to (6), wherein when the shape of the conductor is viewed in a cross section perpendicular to the axis of the rotation transmission member, the width of the conductor in the circumferential direction of the axis is greater than the thickness of the conductor.(8) A light irradiation device according to any one of (1) to (7), further comprising a support provided at the tip of the device body for supporting the laser light source, wherein the support and the rotation transmission member are fixed together. (9) A light irradiation device according to (8), further comprising an intermediate member interposed between the support and the rotation transmission member to join the support and the rotation transmission member together. (10) A light irradiation device according to (9), further comprising a material having radiopaque properties for at least a portion of the intermediate member. (11) A light irradiation device according to (1) to (10), further comprising a long optical transmission member that receives light from the tip of the device body from which laser light is emitted by the laser light source and transmits the incident light to an optical sensor provided at the base end. (12) A light irradiation device according to (11), further comprising an optical transmission member which is an optical fiber. (13) A light irradiation device according to (11) or (12), characterized in that the light transmission member is disposed inside the hollow rotation transmission member. (14) A long-length medical light irradiation device, comprising: a hollow rotation transmission member having a long-length shape and transmitting rotation between a base end and a tip end; a laser light emission unit that emits laser light from the tip of the long-length device body; a light sensor disposed at the tip of the device body; and a conductor extending from the base end to the tip along the rotation transmission member and electrically connected to the light sensor, characterized in that the conductor is disposed outside the hollow rotation transmission member.(15) A light irradiation system for medical use, comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device comprises: a hollow rotation transmission member having an elongated outer shape and transmitting rotation between a proximal end and a distal end; a laser light source connected to the rotation transmission member at the distal end of the elongated device body and emitting laser light; and a conductor extending from the proximal end to the distal end along the rotation transmission member and electrically connected to the laser light source, wherein the conductor is arranged outside the hollow rotation transmission member. (16) The light irradiation system according to (15), wherein at least a portion of the distal end of the catheter is provided with an outlet for discharging a cooling liquid from the inside of the catheter to the outside. (17) A light irradiation system for medical use, comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device comprises: a hollow rotation transmission member having a long outer shape and transmitting rotation between a proximal end and a tip end; a laser light emission unit that emits laser light from the tip of the long device body; a light sensor disposed at the tip of the device body; and a conductor extending from the proximal end to the tip along the rotation transmission member and electrically connected to the light sensor, wherein the conductor is disposed on the outside of the hollow rotation transmission member. 【0097】 1. Light irradiation system 2. Light irradiation device 3. Catheter 11. Laser light source 12. Support 14A, 14B. Conductor 20. Rotation transmission member 21. Hollow portion 22. Open end 30, 31. Coating layer 40. Intermediate member 60. Optical transmission member 70. Optical sensor 81. Laser light emission part 90. Optical sensor 94A, 94B. Conductor 210. Device body 311. Lumens

Claims

1. A light irradiation device for medical use that is elongated in shape, comprising: a hollow rotation transmission member having an elongated external shape and transmitting rotation between a base end and a tip end; a laser light source connected to the rotation transmission member at the tip of the elongated device body and emitting laser light; and a conductor extending from the base end to the tip end along the rotation transmission member and electrically connected to the laser light source, wherein the conductor is arranged on the outside of the hollow rotation transmission member.

2. A light irradiation device according to claim 1, characterized in that the hollow portion of the rotation transmission member becomes a coolant flow path that allows a coolant for cooling the laser light source to pass from the base end side to the laser light source side.

3. A light irradiation device according to claim 2, wherein the tip of the rotation transmission member is formed with an open end that opens the hollow portion to the outside, and the cooling liquid that has passed through the hollow portion of the rotation transmission member is discharged from the open end toward the laser light source.

4. A light irradiation device according to claim 1 or 2, further comprising the rotational transmission member and a covering layer that covers the outer circumference of the conductor disposed outside the rotational transmission member.

5. A light irradiation device according to claim 1 or 2, further comprising a covering layer covering the outer circumference of the rotation transmission member, wherein the conductor is arranged outside the covering layer covering the outer circumference of the rotation transmission member.

6. A light irradiation device according to claim 1, wherein the conductor is an insulated coated conductor or a flexible substrate having flexibility, and two or more transmission lines are constructed to the laser light source.

7. A light irradiation device according to claim 1, characterized in that, when the shape of the conductor is viewed in a cross section perpendicular to the axis of the rotation transmission member, the width of the conductor in the circumferential direction of the axis is greater than the thickness of the conductor.

8. A light irradiation device according to claim 1, further comprising a support provided at the tip of the device body and supporting the laser light source, wherein the support and the rotation transmission member are fixed to each other.

9. A light irradiation device according to claim 8, further comprising an intermediate member interposed between the support and the rotational transmission member to join the support and the rotational transmission member together.

10. A light irradiation device according to claim 9, characterized in that at least a portion of the intermediate member is formed of a material having radiopaque properties.

11. A light irradiation device according to claim 1, further comprising a long light transmission member that receives light from the tip of the device body from which laser light is emitted by the laser light source, and transmits the incident light to a light sensor provided on the base end.

12. An optical irradiation device according to claim 11, characterized in that the optical transmission member is an optical fiber.

13. A light irradiation device according to claim 11, characterized in that the light transmission member is disposed inside the hollow rotation transmission member.

14. A light irradiation device for medical use, having an elongated shape, comprising: a hollow rotation transmission member having an elongated external shape and transmitting rotation between a base end and a tip end; a laser light emission section that emits laser light from the tip end of the elongated device body; a light sensor disposed at the tip end of the device body; and a conductor extending from the base end to the tip end along the rotation transmission member and electrically connected to the light sensor, wherein the conductor is disposed on the outside of the hollow rotation transmission member.

15. A light irradiation system for medical use, comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device comprises: a hollow rotation transmission member having an elongated outer shape and transmitting rotation between its proximal end and tip; a laser light source connected to the rotation transmission member at the tip of the long device body and emitting laser light; and a conductor extending along the rotation transmission member from the proximal end to the tip and electrically connected to the laser light source, wherein the conductor is arranged outside the hollow rotation transmission member.

16. A light irradiation system according to claim 15, characterized in that at least a portion of the tip of the catheter has an outlet formed therein for discharging a cooling liquid from the inside of the catheter to the outside.

17. A light irradiation system for medical use, comprising: a catheter formed in the shape of a long tube; and a long light irradiation device inserted into the lumen of the catheter, wherein the light irradiation device comprises: a hollow rotation transmission member having an elongated outer shape that transmits rotation between a proximal end and a tip end; a laser light emission section that emits laser light from the tip of the long device body; a light sensor disposed at the tip of the device body; and a conductor extending from the proximal end to the tip end along the rotation transmission member and electrically connected to the light sensor, wherein the conductor is disposed on the outside of the hollow rotation transmission member.

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