Modified organisms and methods of producing aerobically-stabilized nitrogenase
Engineered organisms with non-native nitrogenase and ROS scavenging enzymes enhance nitrogenase stability and activity in aerobic conditions, addressing ROS limitations and improving nitrogen fixation efficiency.
WO2026128410A1PCT designated stage Publication Date: 2026-06-18SOURCE F7 INC
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- SOURCE F7 INC
- Filing Date
- 2025-12-09
- Publication Date
- 2026-06-18
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Figure US2025058683_18062026_PF_FP_ABST
Abstract
The present invention provides engineered organisms that can stably express functional polypeptides in the presence of ROS. The present invention also provides engineered organisms that can stably express nitrogenase. Also provided are methods to generate engineered organisms that can stably express nitrogenase by providing non-native nitrogenase and introducing one or more helper factors that facilitate scavenging of ROS or suppress ROS-generating enzymes
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