Bifunctional compound for targeted degradation of androgen receptor protein and use thereof
By designing bifunctional compounds that target androgen receptor proteins and utilizing the PROTAC mechanism to achieve efficient degradation of androgen receptors (AR), the problem of resistance to androgen receptor antagonists in existing technologies has been solved, providing a more effective method for treating androgen-mediated diseases.
WO2026129303A1PCT designated stage Publication Date: 2026-06-25SHANGHAI YIDI BIOTECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- SHANGHAI YIDI BIOTECHNOLOGY CO LTD
- Filing Date
- 2024-12-20
- Publication Date
- 2026-06-25
Smart Images
Figure PCTCN2024141035-FTAPPB-I100001 
Figure PCTCN2024141035-FTAPPB-I100002 
Figure PCTCN2024141035-FTAPPB-I100003
Abstract
The present invention relates to a bifunctional compound represented by formula (I) for targeted degradation of an androgen receptor protein, a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound in preparation of drugs for preventing or treating androgen-mediated diseases.
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