Method for preparing pathological environment-responsive functional nanozyme material and diagnosis and treatment application thereof

By developing pathological environment-responsive functional nanozyme materials, and utilizing their targeted release in the pathological microenvironment of aneurysms and urine detection, non-invasive diagnosis and treatment of aneurysms have been achieved. This solves the problems of insufficient drug treatment and invasive diagnostic methods in existing technologies, and has the advantages of efficient and safe diagnosis and treatment.

WO2026130200A1PCT designated stage Publication Date: 2026-06-25NANJING UNIV
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
NANJING UNIV
Filing Date
2025-12-11
Publication Date
2026-06-25

AI Technical Summary

Technical Problem

There is a lack of effective drug treatments to inhibit the progression of aneurysms, especially for small, asymptomatic aneurysms or patients with anatomically limited aneurysms, and existing diagnostic methods are highly invasive, expensive, and inaccurate.

Method used

Develop a pathological environment-responsive functional nanozyme material that can target and release ultrasmall nanozymes in the pathological microenvironment of aneurysms with high ROS levels, and combine it with urine detection to achieve integrated diagnosis and treatment, utilizing the antioxidant activity and targeting function of nanozymes.

Benefits of technology

It enables non-invasive diagnosis and treatment of aneurysms, reduces drug dosage, lowers side effects, improves diagnostic and treatment efficiency, reduces economic burden, and possesses highly efficient ROS elimination capabilities and safety.

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Abstract

A method for preparing a pathological environment-responsive functional nanozyme material and a diagnosis and treatment application thereof. The pathological environment-responsive functional nanozyme can be used for diagnosing and treating, alleviating and / or preventing arterial diseases. By utilizing the pathological environment-responsive functional nanozyme, the disease microenvironment can be targeted, and meanwhile, ultra-small nanozymes capable of eliminating reactive oxygen species (ROS) are released responsively. In one aspect, the ultra-small nanozymes are metabolized into urine, and the disease course can be reflected by analyzing the enzyme-mimetic catalytic activity of nanozymes in the urine; in another aspect, the excellent antioxidant activity of the ultra-small nanozymes can alleviate the inflammation of the disease site, thereby achieving the effect of preventing and / or treating arterial diseases.
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