Skin compositions and methods of using the same

Abstract

An oil-in-water microemulsion comprising water; an oil selected from an ester oil, a triglyceride, or combinations thereof; a liquid non-ionic surfactant having an HLB from 7 to 13, preferably, from 9 to 13, more preferably, from 9 to 11; and a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer having an HLB value from 15 to 29, preferably, 15 to 28, and more preferably, 16 to 27, wherein the microemulsion is transparent and mono-phasic, and wherein the pH of the microemulsion is between from 4.5 to 7.5, preferably, from 5 to 7, more preferably, from 5.5 to 7.

Description

[0001] SKIN COMPOSITIONS AND METHODS OF USING THE SAME

[0002] Field of the invention

[0003] The present invention is directed to a composition that can be used as, for example, a cleansing composition, more particularly, to remove daily pollutants, residues, and makeup.

[0004] Background of the Invention

[0005] Many consumers will choose to apply different makeup products to their skin, especially to their face. Even if some consumers choose to wear minimal or no makeup, sunscreen products are often applied daily to help protect the skin from harmful UV rays.

[0006] Makeup removers are known in the art, and used by many consumers, sometimes daily, to remove, for example, makeup and the like from skin. However, so-called “stay put” or “stubborn” makeup such as waterproof mascara, and long-lasting products (such as heavy foundations and lip products including lip stains) that can be specifically designed to have transfer-resistance qualities, are known to be tough to remove. Moreover, some sunscreens, especially those prone to white-cast, can be especially difficult to remove. While there are many different products currently available, some consumers are still looking for a product that not only an effective makeup remover for such “stay put” makeup, but also does not require scrubbing, does not cause irritation, does not harm the skin barrier, and is free from oily or greasy residues. Additionally or alternatively, some consumers wish to refresh their skin throughout the day, but want to maintain and want a product that does not cause irritation, does not harm the skin barrier, and can provide some skin benefits.

[0007] The present invention addresses the above unrealized needs by providing stable microemulsions and methods of using such microemulsions for excellent makeup removing properties by being able to more effectively remove makeup compared to some conventional compositions such as bi-phasic composition and micellar waters while being able to leave skin feeling moisturized, refreshed, without any greasy or oily feeling after use, and can even impart some skin benefits as well as can help promote a more balanced and healthy microbiome. Unlike biphasic compositions that need to be shaken before use to ensure homogeneity, the inventors have found it is possible to make a stable single phase microemulsion that surprisingly and unexpectedly can work as well as, if not better than, traditional bi-phasic or micellar water compositions, is stable, can be used on any skin type (including oily or acne prone skin, dry skin and / or sensitive skin), does not cause irritation, is less harsh, does not require scrubbing, and has excellent skin feel properties including not leaving skin feeling oily or greasy. Additionally, the microemulsions described herein can be used in an impregnation liquid for wipes, including cleansing wipes and makeup remover wipes.

[0008] Summary of the Invention

[0009] In a first aspect, the present invention is directed to a oil-in-water microemulsion comprising: from 1 to 14 wt%, preferably, from 3 to 14 wt%, more preferably from 5 to 14 wt%, and most preferably, from 10 to 14 wt%, of water; an oil selected from an ester oil, a triglyceride, or combinations thereof; a liquid non-ionic surfactant having an HLB from 7 to 13, preferably, from 9 to 13, more preferably, from 9 to 11 ; and a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer having an HLB value from 15 to 29, preferably, from 15 to 28, and more preferably, from 16 to 27, wherein a weight ratio of the non-ionic surfactant to the polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer is from 6:1 to 1 :1 , preferably, from 4:1 to 1 :1 , and more preferably, from 3:1 to 1 :1 , wherein a weight ratio of the non-ionic surfactant to water is from 6: 1 to 1 : 1 , or from 5: 1 to 2: 1 , or from 4:1 to 3: 1 , wherein the microemulsion is transparent and mono-phasic, and wherein the pH of the microemulsion is between from 4.5 to 7.5, preferably, from 5 to 7, more preferably, from 5.5 to 7.

[0010] In another aspect, the present invention is directed to a method of using the oil-in-water microemulsion, as described herein, wherein the oil-in-water microemulsion is applied to skin to remove makeup.

[0011] In yet another aspect, the present invention is directed to using the oil-in-water microemulsion, as described herein, as a makeup remover. In yet another aspect, the present invention is directed to using the water-in-oil microemulsion, as described herein, to provide skin care benefits, and optionally, a sunscreen.

[0012] In yet another aspect, the present invention is directed to making a diluted microemulsion solution comprising the microemulsion described herein and a solvent, such that the diluted microemulsion solution can be used to remove makeup or impregnate wipes to remove makeup.

[0013] All other aspects of the present invention will more readily become apparent from the description and examples which follow.

[0014] Detailed Description of the Invention

[0015] Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and / or use may optionally be understood as modified by the word “about”.

[0016] All amounts are by weight of any of the compositions or components thereof, unless otherwise specified. It should be noted that in specifying any ranges of values, any particular upper value can be associated with any particular lower value.

[0017] For the avoidance of doubt, the term "comprising" is meant not to be limiting to any stated elements but rather to encompass non-specified elements of major or minor functional importance. Therefore, the listed steps, elements or options need not be exhaustive. Whenever the words "including" or "having" are used, these terms are meant to be equivalent to "comprising" as defined above.

[0018] Skin care benefit, as used herein, refers to an improvement in a facial or body characteristic after topical application, for example, even skin tone such as skin brightening and / or glow, skin texture such as reduction in wrinkles, fine lines and / or age spots, dry skin, anti-acne or the like. The disclosure, as found herein, is to be considered to cover all embodiments as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy.

[0019] In one aspect, the present invention is directed to a oil-in-water microemulsion comprising: from 1 to 14 wt%, preferably from 3 to 14 wt%, more preferably from 5 to 14 wt%, and most preferably, from 10 to 14 wt%, of water; an oil selected from an ester oil, a triglyceride, or combinations thereof; a liquid non-ionic surfactant having an HLB from 7 to 13, preferably, from 9 to 13, more preferably, from 9 to 11; and a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer having an HLB value from 15 to 29, preferably, from 15 to 28, and more preferably, from 16 to 27, wherein a weight ratio of the non-ionic surfactant to the polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer is from 6:1 to 1 :1 , preferably, from 4:1 to 1 :1 , and more preferably, from 3:1 to 1 :1, wherein a weight ratio of the non-ionic surfactant to water is from 6: 1 to 1 : 1 , or from 5: 1 to 2: 1 , or from 4:1 to 3: 1 , wherein the microemulsion is transparent and mono-phasic, and wherein the pH of the microemulsion is between from 4.5 to 7.5, preferably, from 5 to 7, more preferably, from 5.5 to 7. Oil-in-water (or O / W) microemulsions comprise an oil phase is dispersed in an aqueous phase.

[0020] Microemulsion, as used herein, is meant a thermodynamically stable liquid dispersion of an oil phase and a hydrophilic phase. The dispersed phase typically comprises small particles or droplets, with a size range of 5 nm to 200 nm, giving rise to a microemulsion that is, preferably, transparent in appearance. This is in contrast to regular (macro-) emulsions that are turbid. The droplets or particles of the microemulsion may be spherical, although other structures are possible. The microemulsion is formed readily and sometimes spontaneously, generally without high- energy input. Additionally, the present microemulsion is single phase or monophasic, as opposed to being bi-phasic where each of the aqueous and oil phases are separate and require the user to mix prior to use. In one aspect, the pH of the microemulsion is from 4.5 to 7.5, preferably, from 5 to 7, more preferably, from 5.5 to 7. Adjusters suitable to modify the pH of the composition as described herein may be used. Such pH adjusters include but are not limited to triethylamine, NaOH, KOH, H2SO4, HCI, CeHsO? (i.e. , citric acid) and / or mixtures thereof. Buffers, like potassium oxide, to stabilize pH are also suitable for use. The pH of the composition is assessed by using conventional instrumentation such as a pH meter made commercially available from Thermo Scientific®.

[0021] Transparent, as used herein, means that light is transmitted without appreciable scattering, like glass, allows for ready viewing of objects behind it. “Translucent”, as used herein, although allowing light to pass through the emulsion, causes the light to be scattered so that objects behind the translucent emulsion, while visible, are less clearly identified. Finally, “opaque”, as defined herein, is not transparent or translucent; and instead, is impenetrable to light or not allowing light to pass through the emulsion. The microemulsion described herein is transparent or translucent, preferably, transparent.

[0022] Makeup, as used herein, may refer to liquid-pigmented makeup (e.g., foundations, BB creams, skin tints, and liquid blushes), lip products (e.g., lipstick, lip liners, lip stains, lip balms, lip gloss), primers, mascara, eyeshadow, eyeliner, concealer, highlighters, bronzers, powders, blushes, makeup setting sprays, glitter, and the like.

[0023] The microemulsion disclosed herein has from 1 to 14 wt%, preferably, from 3 to 14 wt%, more preferably, from 5 to 14 wt%, and most preferably, from 10 to 14 wt%, of water.

[0024] The microemulsion disclosed herein has an oil, specifically, an ester oil, a triglyceride, or any combinations thereof.

[0025] Suitable ester oils may include isocetyl stearate, octyl dodecyl myristate, butyl octyl salicylate, isostearyl isostearate, cetearyl isononanoate, cetearyl ethylhexanoate, cetyl ethyl hexanoate, ethyl hexyl palmitate, isopropyl myristate, isopropyl neopentanoate, isopropyl isosterate, isostearyl neopentanoate, isodecyl neopentanoate and / or isopropyl palmitate, preferably, isopropyl neopentanoate, isostearyl neopentanoate, isodecyl neopentanoate.

[0026] Suitable triglycerides may include soybean oil, sunflower oil, coconut oil, palm kernel oil, castor oil, rapeseed oil, palm oil, grape seed oil, hemp seed oil, caprylic / capric triglyceride, safflower oil, fish oil, and combinations thereof, preferably, grapeseed oil, hempseed oil, coconut oil, and combinations thereof. In one aspect, the microemulsion may optionally include at least one additional optional oil. Suitable additional optional oils include silicone oil, linear or branched alkanes comprising 8 to 34 carbons, mineral oil, fatty acids, and oil-soluble sunscreens.

[0027] Suitable silicone oil includes volatile and nonvolatile silicone oils. The term "volatile" as used herein refers to those materials which have a measurable vapor pressure at ambient temperature. Volatile silicone oils are preferably chosen from cyclic (cyclomethicone) or linear polydimethylsiloxanes containing from 3 to 9, preferably, from 4 to 5, silicon atoms, preferably, cyclotetrasiloxane (D4), cyclopentasiloxane (D5), cyclohexasiloxane (D6), hexamethyldisiloxane, and / or mixtures thereof. Nonvolatile silicones include nonvolatile silicone oils such as polyalkyl siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers, including dimethicones and caprylyl methicone, and silicone waxes such as dimethicone copolyol laurate. When used, the silicone oil is preferably a volatile silicone oil, more preferably, cyclopentasiloxane. Suitable linear or branched alkane comprising 8 to 34 carbons include liquid paraffins and / or alkanes such as C9-C15 paraffins and / or alkanes, including a C10-13 alkane, a C13-C15 alkane, C11-C13 paraffins and / or alkanes, liquid isoparaffins and / or isoalkanes such as C9-C15 isoparaffins and / or isoalkanes, preferably, C11-C13 isoparaffins and / or isoalkanes, isododecane, isohexadecane, a C12-C17 alkane, a C15-19 alkane, a C14-C22 alkane, a C18-21 alkane, and any combination thereof. Suitable fatty acids include lauric, myristic, palmitic, stearic, behenic, oleic, linoleic, linolenic, lanolic, isostearic, arachidonic and polyunsaturated fatty acids (PLIFA).

[0028] Suitable oil-soluble sunscreens include octyl salicylate, 3,3,5-trimethylcyclohexyl 2- hydroxybenzoate (“homosalate”), ethylhexyl salicylate (“octisalate”), 2-ethylhexyl 2- cyano-3,3-diphenylprop-2-enoate (“octocrylene”), or 2-ethylhexyl-4-methoxycinnamate (also known as octyl methoxycinnamate or “OMC”), 4-t-butyl-4’- methoxydibenzoylmethane (“avobenzone”), 2-methyldibenzoylmethane, 4-methyl- dibenzoyl-ethane, 4-isopropyldibenzoyl-methane, 4-tert-butyldibenzoylmethane, 2,4- dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4’- diisopropyldibenzoylmethane, 2-methyl-5-isopropyl-4’-methoxy-dibenzoylmethane, 2- methyl-5-tert-butyl-4’-methoxy-dibenzoylmethane, 2,4-dimethyl-4’- methoxydibenzoylmethane, 2,6-dimehyl-4-tert-butyl-4’methoxy-dibenzoylmethane, diethylaminohydroxybenzoyl hexyl benzoate, or methyl anthranilate. Another suitable oil-soluble sunscreen includes Bemotrizinol (BEMT). Additional oil-soluble sunscreens include those commercially available from BASF corporation: llvinul T-150 (Ethylhexyl triazone; a IIV-B sunscreen oil), llvinul A Plus (Diethylamino hydroxy benzoyl hexyl benzoate; a IIV-A sunscreen oil), Tinosorb S (bis-ethylhexyloxyphenol methoxyphenyl triazine; a IIV-A and IIV-B sunscreen oil), Tinosorb M (methylene bisbenzotriazolyl tetramethylbutylphenol; a IIV-A and IIV-B sunscreen oil), Mexoryl XL, and / or Mexoryl 400. Preferably, the sunscreen is 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate (“homosalate”), ethylhexyl salicylate (“octisalate”), 2-ethylhexyl 2-cyano-3,3- diphenylprop-2-enoate (“octocrylene”), 4-t-butyl-4’-methoxydibenzoylmethane (“avobenzone”), and / or any mixtures of combinations thereof. In one aspect, the microemulsion is substantially free of any additional optional oils.

[0029] In one aspect, the microemulsion has a total amount of the oil (i.e., ester oil, triglyceride, or any combinations thereof) and an additional optional oil is present in an amount from 1 to 10 wt%, preferably, from 2 to 8 wt%, more preferably, from 3 to 7 wt%, and even more preferably, from 4 to 7 wt%, based on the total weight of the microemulsion, wherein at least 80 wt%, preferably, from 80 to 100 wt%, more preferably, from 80 to 95 wt% is the ester oil, triglyceride, or any combinations thereof.

[0030] As used herein, “substantially free of” refers to having less than 3 wt%, or less than 1 wt%, or less than 0.5 wt%, or less than 0.1 wt%, or less than 0.01 wt% of the compound, by weight of the microemulsion, In one aspect, “substantially free of” refers to having from 0.00001 wt% to 1.5 wt%, or 0.00001 wt% to 1 wt%, or 0.00001 wt% to 0.5 wt% of the compound, by weight of the microemulsion, preferably free of such compound (e.g., 0.0 wt%).

[0031] In one aspect, the microemulsion includes a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer having an HLB value from 14 to 29, preferably, 15 to 28, and more preferably, 15 to 27. Suitable triblock polymers include Poloxamer 108, Poloxamer 338, Poloxamer 124, Poloxamer 122, Poloxamer 407, Poloxamer 238, Poloxamer 184, Poloxamer 188, and any combination thereof. In one aspect, the microemulsion is substantially free of a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer. In one aspect, the amount of the polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer is from 2 to 30 wt%, preferably, from 10 to 28 wt%, more preferably, from 16 to 26 wt%, and even more preferably, from 22 to 26 wt%, based on the total weight of the microemulsion. The microemulsion disclosed herein has an oil a liquid non-ionic surfactant having an HLB from 7 to 13, preferably, from 9 to 13, more preferably, from 9 to 11. As used herein, liquid refers a surfactant which remains as a flowable liquid at temperature of 10°C to 35°C, preferably, from 10°C to 30°C, and more preferably, from 15°C to 25°C and has viscosity of from 10 to 7000 cps, preferably, from 10 to 5000 cps, more preferably, from 25 to 4000 cps, and even more preferably, from 50 to 1000 cps.

[0032] Suitable non-ionic surfactants include fatty acid ethoxylates, polyethoxylated sorbitan fatty acid esters, ethoxylated fatty alcohols, products of ethylene oxide and propylene oxide with fatty alcohols, alkyl glucosides, and combinations thereof. In one aspect, the microemulsion has from 30 to 70 wt%, preferably, from 40 to 65 wt%, more preferably, from 45 to 60 wt%, and even more preferably, from 50 to 60 wt% of liquid non-ionic surfactant, based on the total weight of the microemulsion.

[0033] Suitable fatty acid ethoxylates include PEG-30 stearate, PEG- 10 stearate, PEG-7 stearate, PEG-50 stearate, PEG-30 oleate, PEG-10 oleate, PEG-7 oleate, PEG-30 cocoate, PEG-7 cocoate, and PEG-5 cocoate, preferably, PEG-7 cocoate, PEG-5 cocoate, and combinations thereof.

[0034] Suitable polyethoxylated sorbitan fatty acid ester include Polysorbate-65, Polysorbate- 80, Polysorbate-85, and combinations thereof.

[0035] Suitable ethoxylated fatty alcohols include Oleth-2, Laneth-2, Laureth-3, Oleth-3, Laureth-4, Oleth-4, Laneth-4, Laureth-5, Oleth-5, Ceteareth-5, Laneth-5, Deceth-7, Laureth-7, Oleth-7, Coceth-7, Ceteth-7, Ceteareth-7, C11-15 Pareth-7, Laureth-9, Oleth-9, Ceteareth-9, Laureth-10, Oleth-10, Beheneth-10, Ceteareth-10, Ceteareth-12, Laneth-15, Oleth-16, Oleth-20, and combinations thereof.

[0036] Suitable products of ethylene oxide and propylene oxide with fatty alcohols include PPG-5 Ceteth-20, PPG-6 Deceth-9, PPG-1 Trideceth-6, PPG-6 Deceth-4, PPG-1- Laureth-9; PPG-12-Laneth-50, PPG-5-Ceteth-20, PPG-12-Laneth-65, PPG-6 C12-18 Pareth-11, PPG-4 Laureth-2, PPG-4 Laureth-5, PPG-8 Deceth-6, PPG-6 C12-18 Pareth-11, PPG-1 -Laureth-9, PPG-5-Ceteth-20, PPG-5-Laureth-5, PPG-26-Buteth-26, PPG-20 Buteth-30, PPG-5 Buteth-7, PPG-12 Buteth-16, PPG-2 Buteth-3, PPG-3 Buteth-5, PPG-28 Buteth-35, PPG-33 Buteth-45, PPG-7 Buteth-10, PPG-24-Buteth-27, and combinations thereof.

[0037] Suitable alkyl glucosides have from 1 to about 5 glucoside units, and an alkyl chain length of from about 8 to about 18 including alkyl polyglucosides based on C8-C18 fatty alcohols, including capryl glucoside, decyl glucoside, coco-glucoside, and lauryl glucoside; primary alcohol alkoxylates such as nonylphenol ethoxylates and octylphenol ethoxylates, and any combination thereof.

[0038] Optionally, the microemulsion described herein may include an additional surfactant including anionic surfactant, a cationic surfactant, an amphoteric surfactant, and / or a zwitterionic surfactant.

[0039] Other optional surfactants can include those which are amphoteric (which depending on pH can be zwitterionic). Illustrative optional amphoteric surfactants suitable for use generally include sodium acyl amphoacetates, sodium acyl amphopropionates, disodium acyl amphodiacetates and disodium acyl amphodipropionates where the acyl (i.e., alkanoyl group) can comprise a C7-C18 alkyl portion. Illustrative examples of the amphoteric surfactants that may be used include sodium lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphoacetate, sodium cocoamphoacetate and / or mixtures thereof or the like.

[0040] As to zwitterionic surfactants that may optionally be used in the composition described herein, such surfactants typically include at least one acid group. Such an acid group may be a carboxylic or a sulphonic acid group. They often include quaternary nitrogen, and therefore, can be quaternary amino acids. They should generally include an alkyl or alkenyl group of 7 to 18 carbon atoms and generally comply with an overall structural formula:

[0041] R1-[-C(O)-NH(CH2)q-]r--N+(R2)(R3)A-B where R1is alkyl or alkenyl of 7 to 18 carbon atoms; R2and R3are each independently alkyl, hydroxyalkyl or carboxyalkyl of 1 to 3 carbon atoms; q is 2 to 4; r is 0 to 1 ; A is alkylene of 1 to 3 carbon atoms optionally substituted with hydroxyl, and B is --CO2-- or -SO3-.

[0042] Suitable zwitterionic surfactants for use in the composition, as described herein, and within the above general formula include simple betaines of formula: RI-N+(R2)(R3)-CH2CO2- and amido betaines of formula:

[0043] R1-CONH(CH2)t-N+-(R2)(R3)CH2CO2-where t is 2 or 3.

[0044] In both formulae R1, R2and R3are as defined previously. R1may, in particular, be a mixture of Ci2and C14 alkyl groups derived from coconut oil so that at least half, preferably at least three quarters of the groups R1have 10 to 14 carbon atoms. R2and R3are preferably methyl.

[0045] A further possibility is that the zwitterionic surfactant is a sulphobetaine of formula:

[0046] R1-N+(R2)(R3)-(CH2)3SO3- or

[0047] R1-CONH(CH2)U-N+(R2)(R3)-(CH2)3SO3- where u is 2 or 3, or variants of these in which --(CH2)3SO3- is replaced by -- CH2C(OH)(H)CH2SO3-.

[0048] In these formulae, R1, R2and R3are as previously defined.

[0049] Illustrative examples of the zwitterionic surfactants include betaines like cocodimethyl carboxymethyl betaine, cocoamidopropyl betaine and laurylamidopropyl betaine. An additional zwitterionic surfactant suitable for use includes cocoamidopropyl sultaine. Such surfactants are made commercially available from suppliers like Stepan Company, and it is within the scope of the invention to optionally employ mixtures of the same.

[0050] Optional surfactants may also include cationic surfactants. One class of cationic surfactants includes heterocyclic ammonium salts such as cetyl or stearyl pyridinium chloride, alkyl amidoethyl pyrrylinodium methyl sulfate, and lapyrium chloride. Tetra alkyl ammonium salts are another useful class of cationic surfactants for use. Examples include cetyl or stearyl trimethyl ammonium chloride or bromide, such as cetyltrimethylammonium chloride; hydrogenated palm or tallow trimethylammonium halides; behenyl trimethyl ammonium halides or methyl sulfates; decyl isononyl dimethyl ammonium halides; ditallow (or distearyl) dimethyl ammonium halides, and behenyl dimethyl ammonium chloride. Still other types of cationic surfactants that may be used are the various ethoxylated quaternary amines and ester quats. Examples include PEG- 5 stearyl ammonium lactate (e.g., Genamin KSL manufactured by Clariant), PEG-2 coco ammonium chloride, PEG-15 hydrogenated tallow ammonium chloride, PEG 15 stearyl ammonium chloride, dipalmitoyl ethyl methyl ammonium chloride, dipalmitoyl hydroxyethyl methyl sulfate, and stearyl amidopropyl dimethylamine lactate. Still other useful cationic surfactants include quaternized hydrolysates of silk, wheat, and keratin proteins, and it is within the scope of the cleansing composition to use mixtures of the aforementioned cationic surfactants. In one aspect, when used, the cationic surfactant is cetrimonium chloride, cetylpyridinium chloride and / or mixtures thereof.

[0051] Optional surfactants may also include anionic surfactants. Illustrative examples of anionic surfactants include aliphatic sulfonates, such as a primary alkane (e.g., C8-C22) sulfonate, primary alkane (e.g., C8-C22) disulfonate, C8-C22 alkene sulfonate, C8-C22 hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate (AGS); or aromatic sulfonates such as alkyl benzene sulfonate. The anionic surfactant may also be an alkyl sulfate (e.g., C12-C18 alkyl sulfate) or alkyl ether sulfate (including alkyl glyceryl ether sulfates). Among the alkyl ether sulfates are those having the formula:

[0052] RO(CH2CH2O)nSO3M wherein R is an alkyl or alkenyl having 8 to 18 carbons, preferably 12 to 18 carbons, n has an average value of at least 1.0, preferably less than 5, and most preferably 1 to 4, and M is a solubilizing cation such as sodium, potassium, ammonium or substituted ammonium.

[0053] The anionic surfactant may also be alkyl sulfosuccinates (including mono- and dialkyl, e.g., C6-C22 sulfosuccinates); alkyl and acyl taurates (often methyl taurates), alkyl and acyl sarcosinates, sulfoacetates, C8-C22 alkyl phosphates and phosphonates, alkyl phosphate esters and alkoxyl alkyl phosphate esters, acyl lactates, C8-C22 monoalkyl succinates and maleates, sulphoacetates, alkyl glucosides and acyl isethionates, and the like. Sulfosuccinates may be monoalkyl sulfosuccinates having the formula:

[0054] R1OC(O)CH2CH(SO3M)CO2M; and amide-MEA sulfosuccinates of the formula:

[0055] R1CONHCH2CH2OC(O)CH2CH(SO3M)CO2M wherein R1ranges from Cs-C22alkyl.

[0056] Sarcosinates are generally indicated by the formula:

[0057] R2CON(CH3)CH2CO2M, wherein R2ranges from C3-C2o alkyl.

[0058] Taurates are generally identified by formula:

[0059] R3CONR4CH2CH2SO3M wherein R3is a Cs-C2o alkyl, R4is a C1-C4 alkyl.

[0060] M is a solubilizing cation as previously described.

[0061] The composition disclosed herein may contain Cs-Cis acyl isethionates. These esters are prepared by a reaction between alkali metal isethionate with mixed aliphatic fatty acids having from 6 to 18 carbon atoms and an iodine value of less than 20. At least 75% of the mixed fatty acids have from 12 to 18 carbon atoms and up to 25% have from 6 to 10 carbon atoms.

[0062] The acyl isethionate may be an alkoxylated isethionate such as is described U.S. Pat. No. 5,393,466, which is hereby incorporated by reference. This compound has the general formula:

[0063] R5C— (0)0— C(X)H— C(Y)H— (OCH2— CH2)m— SO3M wherein R5is an alkyl group having 8 to 18 carbons, m is an integer from 1 to 4, X and Y are each independently hydrogen or an alkyl group having 1 to 4 carbons and M is a solubilizing cation as previously described.

[0064] In an aspect of the composition, the anionic surfactant, if used, is 2-acrylamido-2- methylpropane sulfonic acid, ammonium lauryl sulfate, ammonium cocoyl sulfate, ammonium perfluorononanoate, potassium lauryl sulfate, potassium cocoyl sulfate, sodium alkyl sulfate, sodium dodecyl sulfate, sodium laurate, sodium laureth sulfate, sodium lauroyl sarcosinate, sodium stearate, sodium sulfosuccinate esters, sodium lauroyl isethionate, or a combination thereof. Such anionic surfactants are commercially available from suppliers like Galaxy Surfactants, Clariant, Sino Lion, Stepan Company, and Innospec.

[0065] When present, the amount of optional surfactants included, by weight of the composition described herein, is collectively no more than 4%, or no more than 3%, or no more than 2%, or no more than 1%. In one aspect, the amount of optional surfactants included, by weight of the composition described herein, is collectively about 0.001% to about 4%, or about 0.01% to about 4%, or about 0.1% to about 2%, or about 0.1% to about 1%, or about 0.1% to about 0.75%, including all ranges and amounts subsumed therein. Alternatively, the microemulsion may be substantially free of any additional surfactants.

[0066] In one aspect, the weight ratio of the non-ionic surfactant to the total oil is from 20:1 to 1:1 , preferably, from 15:1 to 5:1 , and more preferably, from 12:1 to 7:1. in one aspect, humectants, such as water-soluble polyols, can be included in the composition disclosed herein. These include sorbitol, glycerol (or glycerine), mannitol, xylitol, maltitol and / or mixtures thereof. Other humectants include propylene glycol, dipropylene glycol, polypropylene glycol (e.g., PPG-9), polyethylene glycol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, propanediol, 1 ,2-octane diol, 1,2-hexane diol, isoprene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and / or mixtures thereof. In one aspect, the humectant is glycerol. In one aspect, the humectant is a combination of glycerol and hexylene glycol. In one aspect, optionally skin care benefit agents may include, such as, water-soluble and oil-soluble vitamins, resorcinols, glutathione precursors, peroxisome proliferator- activated receptor (PPAR) activators, and the like.

[0067] Suitable water-soluble vitamins may include vitamin B1 and its precursors or derivatives (such as thiamine), vitamin B3 and its precursors or derivatives (such as niacinamide); vitamin B5 and its precursors or derivatives (such as panthenol and its precursors or derivatives); vitamin B6, vitamin B7, vitamin B9, vitamin C and its precursors or derivatives (such as tetrahexyldecyl ascorbate, ascorbyl palmitate); and alpha lipoic acid. Suitable oil-soluble vitamins include vitamin A and its precursors or derivatives including retinoids such as retinol, beta-carotene, retinal, retinoic acid and C2-20 esters of retinol (such as retinyl palmitate, retinyl propionate, retinyl formate, retinyl acetate, retinyl butyrate, retinyl valerate, retinyl isovalerate, retinyl hexanoate, retinyl heptanoate, retinyl octanoate, retinyl nonanoate, retinyl decanoate, retinyl undecandate, retinyl taurate, retinyl tridecanoate, retinyl myristate, retinyl pentadecanoate, retinyl heptadeconoate, retinyl stearate, retinyl isostearate, retinyl nonadecanoate, retinyl arachidonate, retinyl behenate, retinyl linoleate, and retinyl oleate); vitamin D and its precursors or derivatives, vitamin E and its precursors or derivatives (such as tocopherol, d-alpha-tocopherol, tocopheryl acetate); vitamin K and its precursors or derivatives; selenium and its derivatives (such as L- selenomethionine). When used, from 0.0001 wt% to 10 wt%, or from 0.001 wt% to 8 wt%, or from 0.01 wt% to 5 wt%, or from 0.01 wt% to 3 wt%, or from 0.01 wt% to 2 wt%, or from 0.01 wt% to 1 wt%, or from 0.01 to 0.5 wt%, or from 0.01 to 0.1 wt%, or from 0.1 to 0.5 wt%, by weight of each of such ingredients, based on the total weight of the microemulsion.

[0068] A resorcinol, which is a monohydroxy phenol compound (i.e., 1 ,3-dihydroxybenzene or 1,3-benzenediol) characterized by alcohol groups (—OH) at positions 1 and 3. The chemical structure of resorcinols may be modified, resulting in substituted resorcinols characterized by at least one substituent in the 2, 4, 5 or 6 position. Substituted, as used herein, refers to a compound in which one or more hydrogen atoms are replaced by another atom or group, e.g., substituent. In one aspect, the substituted resorcinol comprises at least one substituent comprising 5 to 11 carbon atoms, or 5 to 9 carbon atoms. In one aspect, the substituted resorcinol has at least one substituent comprised of an alkyl group or unsaturated alkyl group. In one aspect, the substituted resorcinol is only substituted at position 4 with an alkyl group, e.g., the substituted resorcinol is a 4-substituted alkyl resorcinol, including but not limited to 4-methyl resorcinol, 4-ethyl resorcinol, 4-hexyl resorcinol, 4-cyclohexyl resorcinol, 4-propyl resorcinol, 4-isopropyl resorcinol, 4-butyl resorcinol, 4-pentyl resorcinol, 4-phenylethyl resorcinol, 4-cyclopentyl resorcinol, 4-cyclohexyl resorcinol, 4- heptyl resorcinol, 4-cycloheptyl resorcinol, 4-octyl resorcinol, 4-cyclooctyl resorcinol, 4- nonyl resorcinol, 4-decyl resorcinol, 4-undecyl resorcinol, 4-dodecyl resorcinol and / or combinations or mixtures thereof. Preferably, the substituted resorcinol is 4- ethylresorcinol, 4-hexylresorcinol, and 4-isopropylresorcinol. In one aspect, the substituted resorcinol is substituted at position 4 with a substituted or unsubstituted 5- or 6-membered ring carbon-based heterocyclic ring containing one or more heteroatoms selected from N, S or O, preferably a substituted 5-membered ring carbon-based heterocyclic ring containing two heteroatoms selected from N or S, e.g., isobutylamido thiazolyl resorcinol or thiamidol. When used, from 0.0001 wt% to 10 wt%, or from 0.001 wt% to 8 wt%, or from 0.01 wt% to 5 wt%, or from 0.01 wt% to 3 wt%, or from 0.01 wt% to 2 wt%, or from 0.01 wt% to 1 wt%, or from 0.01 to 0.5 wt%, or from 0.01 to 0.1 wt%, or from 0.1 to 0.5 wt%, by weight of each of such ingredients, based on the total weight of the microemulsion.

[0069] Glutathione precursors such as a glutamate source (e.g., glutamate) and cystine and, optionally, glycine, as well as salts and esters thereof. Glutamate source can be present in the form of its functional equivalents including glutamine, glutamic acid and / or pyroglutamic acid and / or their salts. In another aspect, a carboxymethyl cysteine compound can be used. The carboxymethyl cysteine compound refers to compound selected from carboxymethyl cysteine, salt of carboxymethyl cysteine, ester of carboxymethyl cysteine, amide of carboxymethyl cysteine or a mixture thereof. Preferably, the carboxymethyl cysteine compound comprises carboxymethyl cysteine, ester of carboxymethyl cysteine, and / or salt of carboxymethyl cysteine. More preferably, the carboxymethyl cysteine compound comprises carboxymethyl cysteine, and / or salt of carboxymethyl cysteine. Even more preferably, carboxymethyl cysteine compound comprises salt of carboxymethyl cysteine. Still even more preferably the carboxymethyl cysteine compound comprises lysine carboxymethyl cysteinate and most preferably, the carboxymethyl cysteine compound is lysine carboxymethyl cysteinate. When used, from 0.0001 wt% to 10 wt%, or from 0.001 wt% to 8 wt%, or from 0.01 wt% to 5 wt%, or from 0.01 wt% to 3 wt%, or from 0.01 wt% to 2 wt%, or from 0.01 wt% to 1 wt%, or from 0.01 to 0.5 wt%, or from 0.01 to 0.1 wt%, or from 0.1 to 0.5 wt%, by weight of each of such ingredients, based on the total weight of the microemulsion.

[0070] A peroxisome proliferator-activated receptor (PPAR) activator such as 10- hydroxystearic acid (10-HSA), 12- hydroxy stearic acid (12-HSA), cis-parinaric acid, trans-7-octadecenoic acid, cis-5, 8,11,14,17 eicosapentanoic acid, cis-4,7, 10, 13, 16, 19 docosahexenoic acid, conjugated linoleic acid (c9,t11), columbinic acid, linolenelaidic acid, ricinolaidic acid, stearidonic acid, 2-hydroxystearic acid, alpha-linolenic acid, arachidonic acid, cis-11,14-eicosadienoic acid, conjugated linoleic acid (t10,c12), conjugated linoleic acid (t9,t11), conjugated linoleic acid (50:50 mix of c9, t11 and t10 c12), coriander acids, linolelaidic acid, monopetroselinic acid, petroselinic acid, ricinoleic acid, stearolic acid, thuja extract or trans vaccenic acid. Even other PPAR activators include cis-11,14,17 eicosatrienoic acid, cis-5 eicosenoic acid, cis-8, 11,14 eicosatrienoic acid, hexadecatrienoic acid, palmitoleic acid, petroselaidic acid, farnesol, cis-13, 16 docosadienoic acid, cis vaccenic acid, cis-11 eicosenoic acid, cis-13,16,19 docosatrienoic acid, cis-13-octadecenoic acid, cis-15-octadecanoic acid, cis-7, 10, 13, 16 docosatetraenoic acid, elaidic acid, gamma-linolenic acid, geranic acid, geranyl geranoic acid, linoleic acid, petroselinyl alcohol, phytanic acid, pinolenic acid, trans-13- octadecenoic acid or tridecyl salicylic acid (TDS). Still other PPAR activators include biochanin A (red clover phytoestrogen), chromolaena odorata extract, pomegranate saponifiable hydrolysable extract, buglossoides (stearidonic plant extract) or zanthalene (extract from Sichuan peppercorn), whereby it is within the scope of the invention to use a mixture of any of the herein noted PPAR activators. In an embodiment of the invention, the PPAR activator is petroselinic acid, conjugated linoleic acid, 12-hydroxystearic acid, ricinoleic acid or a mixture thereof. When used, from 0.0001 wt% to 10 wt%, or from 0.001 wt% to 8 wt%, or from 0.01 wt% to 5 wt%, or from 0.01 wt% to 3 wt%, or from 0.01 wt% to 2 wt%, or from 0.01 wt% to 1 wt%, or from 0.01 to 0.5 wt%, or from 0.01 to 0.1 wt%, or from 0.1 to 0.5 wt%, by weight of each of such ingredients, based on the total weight of the microemulsion.

[0071] Other additional optional skin care benefit agents include at least one of benzethonium chloride, benzalkonium chloride, cetrimonium chloride, zinc pyrithione, chloroxylenol, eugenol, terpineol, thymol, selenium sulfide, piroctone olamine, hinokitiol, linalool, cinnamon oil, lemon grass oil, eucalyptus, vanilla extract, mint extract, orange extract, linseed oil, flaxseed oil or a mixture thereof. If any of such are selected for use, the total amount of those selected for use will (in combined total) be from 0.001 wt% to 4.5 wt%, or from 0.01 wt% to 3.5 wt%, or from 0.01 wt% to 2.5 wt% or from 0.02 wt% to 1 wt%, based on the total weight of the microemulsion.

[0072] Other optional skin active agents include S-adenosyl-L-methionine, a 1 -alkyl nicotinamide having structure I, and a methionine having structure II: wherein Rcis a C1-C4 alkyl, preferably, methyl (N-methyl nicotinamide) and X- is a negative counter ion, preferably, CI-, Rdis methyl, ethyl, propyl, hydroxymethyl, 2- hydroxyethyl, preferably, methyl and Reis H, methyl, ethyl, isopropyl, preferably, H (N- acetyl methionine). Such components are described in WO / 2021 / 008824A1 , the disclosure of which is incorporated herein by reference. In even another embodiment, the microemulsion may comprise acetyl cysteine. When used, from 0.001 wt% to 4.5 wt%, or from 0.01 wt% to 3.5 wt%, or from 0.01 wt% to 2.5 wt% or from 0.01 wt% to 1 wt%, or 0.01 wt% to 0.5 wt%, or 0.01 to 0.3 wt%, or 0.1 wt% to 0.3 wt%, by weight of each of such ingredients, based on the total weight of the microemulsion.

[0073] Conventional preservatives can be incorporated into the microemulsion to protect against the growth of potentially harmful microorganisms. Cosmetic chemists are familiar with appropriate preservatives and routinely choose them to satisfy the preservative challenge test and to provide product stability. While traditional preservatives may be used, such as hydantoin derivatives, isothiazolinones, methyl paraben and / or propyl paraben, as described herein the emulsion of the present invention is preferably substantially free of the same. Other preservatives suitable for use may include iodopropynyl butyl carbamate, phenoxyethanol, hydroxyacetophenone, ethylhexylglycerine, hexylene glycol, imidazolidinyl urea, sodium dehydroacetate, benzyl alcohol, sodium benzoate or mixtures thereof. Even other preservatives suitable for use include sodium dehydroacetate, chlorophenesin and decylene glycol. The preservatives should be selected having regard for the use of the emulsion and possible incompatibilities between the preservatives and other ingredients in the emulsion. Preservatives are preferably employed in amounts from 0.01 wt% to 2.0 wt%, based on the total weight of the microemulsion. Also preferred is a preservative system with hydroxyacetophenone alone or in a mixture with other preservatives. Use of common emollients classified as vicinal diols, like 1,2-octane diol (or other vicinal alkane diols), are also suitable for use with the preservatives described herein and typically at amounts ranging from 0.15 wt% to 1.5 wt%, and preferably, from 0.2 wt% to 1.25 wt%, and most preferably, from 0.25 wt% to 1 wt%, or 0.25 wt% to 0.8 wt%, based on the total weight of the emulsion. In another embodiment of the invention, another preservative suitable for optional use in the present invention comprises capryloyl glycine, undecylenoyl glycine or a mixture thereof. In one aspect, the emulsion is substantially free of parabens. In another aspect, the composition is substantially free of preservatives.

[0074] Fragrances, fixatives, opacifiers (like titanium dioxide), chelators (like EDTA) may optionally be included in the composition as disclosed herein. The amount of optional fragrances, fixatives, opacifiers, and chelators included, by weight of the composition described herein, is collectively from about 0.03% to 3%, or from about 0.1 and 2.6%, including all ranges subsumed therein.

[0075] In another aspect, the present invention is directed to a method of using the oil-in-water microemulsion, as described herein, wherein the oil-in-water emulsion is applied to skin or hair to remove makeup.

[0076] In yet another aspect, the present invention is directed to using the oil-in-water microemulsion, as described herein, as a makeup remover.

[0077] In yet another aspect, the present invention is directed to using the water-in-oil microemulsion, as described herein, to provide skin care benefits, and optionally, a sunscreen.

[0078] In yet another aspect, the present invention is a method of removing makeup from skin comprising applying the microemulsion of any of the preceding claims to skin. No additional rinsing or scrubbing is required, and has excellent skin feel properties including not leaving skin feeling oily or greasy. In yet another aspect, the present invention is directed to a wipe that is impregnated with the microemulsion described herein, and can be used on skin and / or hair to remove makeup.

[0079] It yet another aspect, the present invention is a method of making a diluted microemulsion solution by making the microemulsion described herein, followed by adding a solvent, to the microemulsion, wherein the ratio of the solvent to microemulsion is from 20:80 to 99.9:0.1 , preferably, from 50:1 to 99.5:0.5, and more preferably, from 80:20 to 99:1. The solvent can be selected from water, glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, isopropyl alcohol, ethanol, and any combination thereof. The diluted microemulsion solution is transparent. Further, this diluted microemulsion solution can be applied directly to skin and / or hair to remove, e.g., makeup. Additionally or alternatively, the present invention is directed to a wipe that is impregnated with the microemulsion or diluted microemulsion solution, and can be used on skin and / or hair to remove, e.g., makeup.

[0080] The following Examples are provided to further illustrate an understanding of the invention. The Examples are not intended to limit the scope of the claims.

[0081] Example 1

[0082] Emulsions were prepared by mixing the amounts of the components as indicated in Table 1 into a suitable mixing vessel. A suitable mixing device provides simple agitation mix all ingredients until clear. Suitable mixing devices are those typically used by those skilled in the art and can include a standard overhead mixer, simple spatula, shake mixing, or if desired, a homogenizer can also be used. Surprisingly and unexpectedly, Sample 1 was single phase transparent microemulsion that was clear, can be used on any skin type (including oily or acne prone skin, dry skin and / or sensitive skin), does not cause irritation, is less harsh, does not require scrubbing, and has excellent skin feel properties including not leaving skin feeling oily or greasy.

Claims

CLAIMS1. An oil-in-water microemulsion comprising: from 10 to 14 wt% of water, based on the total weight of the microemulsion; from 3 to 7 wt% of an oil, wherein the oil comprises a triglyceride; a liquid non-ionic surfactant having an HLB from 7 to 13, preferably, from 9 to 13, more preferably, from 9 to 11, wherein the liquid non-ionic surfactant comprises at least one fatty acid ethoxylates selected from PEG-30 stearate, PEG-10 stearate, PEG-7 stearate, PEG-50 stearate, PEG-30 oleate, PEG-10 oleate, PEG-7 oleate, PEG-30 cocoate, PEG-7 cocoate, and PEG-5 cocoate; and a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer having an HLB value from 15 to 29, preferably, from 15 to 28, and more preferably, from 16 to 27, wherein a weight ratio of the non-ionic surfactant to the polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer is from 6:1 to 1:1 , preferably, from 4:1 to 1:1, and more preferably, from 3:1 to 1 :1 , wherein a weight ratio of the non-ionic surfactant to water is from 6:1 to 1 : 1 , or from 5:1 to 2: 1 , or from 4:1 to 3: 1 , wherein the microemulsion is transparent and mono-phasic, and wherein the pH of the microemulsion is between from 4.5 to 7.5, preferably, from 5 to 7, more preferably, from 5.5 to 7.

2. The oil-in-water microemulsion of claim 1 , wherein a total amount of the oil and an additional optional oil is present in an amount from 3 to 10 wt%, based on the total weight of the microemulsion, wherein at least 80%, preferably, from 80 to 100 wt%, more preferably, from 80 to 95 wt% is the oil.

3. The oil-in-water microemulsion of claim 2, wherein the additional optional oil selected from a mineral oil, a fatty acid, a linear or branched alkane comprising 8 to 34 carbons, and / or an oil soluble sunscreen, preferably, wherein the fatty acid is selected from lauric, myristic, palmitic, stearic, behenic, oleic, linoleic,linolenic, lanolic, isostearic, arachidonic, polyunsaturated fatty acids (PLIFA), or any combination thereof.

4. The oil-in-water microemulsion of claim 4, wherein the composition is substantially free of the additional optional oil.

5. The oil-in-water microemulsion of any of the preceding claims, wherein the liquid non-ionic surfactant is PEG-7 cocoate, PEG-5 cocoate, or any combinations thereof.

6. The oil-in-water microemulsion of any of the preceding claims, wherein a total amount of the liquid non-ionic surfactant is from 35 to 70 wt%, preferably, from 40 to 65 wt%, more preferably, from 45 to 60 wt%, more preferably from 50 to 60 wt%, based on a total weight of the microemulsion.

7. The oil-in-water microemulsion of any of the preceding claims, wherein the polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polymer selected from Poloxamer 108, Poloxamer 338, Poloxamer 124, Poloxamer 122, Poloxamer 407, Poloxamer 238, Poloxamer 184, Poloxamer 188, and any combination thereof, wherein an amount the polyethylene glycol / polypropylene glycol / polyethylene glycol tri block polymer is from 2 to 30 wt%, preferably, from 10 to 28 wt%, more preferably, from 16 to 26 wt%, and even more preferably, from 22 to 26 wt%, based on the total weight of the microemulsion.

8. The oil-in-water microemulsion of any of the preceding claims further comprising an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and / or a zwitterionic surfactant.

9. The oil-in-water microemulsion of any of the preceding claims, wherein the emulsion is substantially free of at least one of preservatives, parabens, and sulfates.

10. The oil-in-water microemulsion of any of the preceding claims further comprising one or more skin care benefit agents selected from resorcinols, vitamins, PPARs, terpineol, thymol, and n-acetyl methionine, mixtures thereof or the like.

11. Use of the emulsion of any of the preceding claims for removing makeup from skin.

12. A method of removing makeup from skin comprising applying the microemulsion of any of the preceding claims to skin.

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