Ternary herbicidal composition and use thereof

Abstract

The present invention relates to a ternary herbicidal composition and the use thereof. The ternary herbicidal composition comprises a herbicidally effective amount of active ingredient A, active ingredient B, and active ingredient C, wherein active ingredient A is formula A, active ingredient B is halauxifen-methyl or fluroxypyr-meptyl, and active ingredient C is bipyrazone or dimethyltetrachloroisooctyl ester. The composition can effectively control various weed problems such as gramineous weeds and broadleaf weeds, and has the characteristics of an expanded herbicidal spectrum, a reduced application dosage, the ability to produce a synergistic effect, the capability to overcome resistant weeds, etc.

Description

Ternary herbicidal compositions and their applications Technical Field

[0001] This invention belongs to the field of pesticides, specifically relating to a ternary herbicidal composition and its application. Background Technology

[0002] Chemical weeding is the most economical and effective means of controlling weeds in farmland. However, long-term continuous high-dose use of a single type or a single mode of action of chemical herbicide can easily lead to problems such as herbicide resistance and resistance evolution in weeds.

[0003] The rational combination or mixing of herbicides has advantages such as broadening the weed control spectrum, improving control efficacy, and delaying the occurrence and development of herbicide resistance in weeds. It is one of the most effective methods to solve the above problems. Therefore, there is an urgent need in production to develop herbicide compositions with high safety, broad weed control spectrum, synergistic effects, and the ability to solve the problem of resistant weeds. Summary of the Invention

[0004] To address the aforementioned problems in the existing technology, this invention provides a ternary herbicidal composition and its application. This composition can effectively control various weeds, including grasses and broadleaf weeds, and has the characteristics of broadening the weed control spectrum, reducing the application amount, producing synergistic effects, and solving the problem of resistant weeds.

[0005] A ternary herbicidal composition comprising herbicidally effective amounts of active ingredient A, active ingredient B, and active ingredient C, wherein,

[0006] Active ingredient A is

[0007] Active ingredient B is fluorochloropyridine ester (CAS No.: 943831-98-9) or chlorochloropyridine isooctyl ester (CAS No.: 81406-37-3);

[0008] The active ingredient C is either bispyribac-sodium (CAS No.: 1622908-18-2) or dimethyltetrachloroisooctyl ester (CAS No.: 26544-20-7).

[0009] In one specific embodiment, the weight ratio of A, B and C is 0.1-30:0.1-100:1-200, 0.5-10:0.5-80:3-150, 0.7-8:0.8-60:5-100, 0.8-5:1-20:10-60, 1-4:2-15:15-40 or 2-3:3-4:20-25.

[0010] The herbicidal composition contains A, B, and C at a mass percentage of 1-95% of the total, preferably 10-80%.

[0011] The herbicidal composition also contains conventional adjuvants, including carriers and / or surfactants.

[0012] The term "carrier" in this article refers to an organic or inorganic, natural or synthetic substance. These facilitate the application of the active ingredient and are generally inert and must be agriculturally acceptable, particularly to the plant being treated. Carriers can be solid, such as clay, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc.; or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or waxy hydrocarbons, chlorinated hydrocarbons, liquefied gas, etc.

[0013] Surfactants can include emulsifiers, dispersants, or wetting agents, and can be ionic or nonionic. Examples that may be mentioned include salts of polyacrylic acid, lignin sulfonates, salts of phenol sulfonic acid or naphthalene sulfonic acid, polymers of ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines and substituted phenols (especially alkylphenols or arylphenols), sulfosuccinates, taurine derivatives (especially alkyl taurine esters), and phosphate esters of alcohols or polyhydroxyethylated phenols, alkyl sulfonates, alkyl aryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and sulfated hexadecyl, heptadecanols, and octadecyl alcohols, as well as sulfated fatty alcohol glycol ethers, and naphthalene or naphthalene sulfonic acid with phenol and formaldehyde. Condensations, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol or nonylphenol, alkylphenyl polyethylene glycol ether, tributylphenyl polyethylene glycol ether, tripearylphenyl polyethylene glycol ether, alkylaryl polyether alcohol, alcohols and fatty alcohols / ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ether, ethoxylated polyoxypropylene, lauryl polyethylene glycol ether acetal, sorbitan ester, lignin sulfite waste liquid, and proteins, denatured proteins, polysaccharides (e.g., methylcellulose), hydrophobically modified starch, polyvinyl alcohol, polycarboxylates, polyalkoxylated compounds, polyethyleneamine, polyvinylpyrrolidone and copolymers thereof. At least one surfactant is required to facilitate the dispersion of the active ingredients in water and to facilitate their proper application to plants.

[0014] The above composition may also contain various other components, such as protective colloids, adhesives, thickeners, thixotropic agents, penetrants, stabilizers, chelating agents, dyes, colorants, and polymers.

[0015] The herbicidal composition further comprises at least one safener, preferably one or more of the following: bis(benzyloxazol) (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), pyrazole-methyl (CAS: 135590-91-9), quinoline (CAS: 99607-70-2), gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), and metcamifen (CAS: 129531-12-0).

[0016] In the context of this specification, if the abbreviation of the common name of the active compound is used, it includes, in each case, all conventional derivatives, such as esters and salts, and isomers, particularly optical isomers, especially one or more commercially available forms. If the common name indicates an ester or salt, it also includes, in each case, all other conventional derivatives, such as other esters and salts, free acids and neutral compounds, and isomers, particularly optical isomers, especially one or more commercially available forms. The chemical name of the compound given indicates at least one compound covered by the common name, which is generally preferred. In the case of sulfonamides such as sulfonylureas, the salt also includes salts formed by the exchange of hydrogen atoms in the sulfonamide group with a cation.

[0017] In the context of this invention, the salt of the compound is preferably in the form of its respective alkali metal salt, alkaline earth metal salt or ammonium salt, more preferably in the form of its respective alkali metal salt, more preferably in the form of its respective sodium salt or potassium salt, and most preferably in the form of its respective sodium salt.

[0018] The compositions of the present invention can be diluted or used directly by the user before use. They can be prepared by conventional processing methods, namely, mixing the active substance with a liquid solvent or solid carrier, and then adding one or more surfactants such as dispersants, stabilizers, wetting agents, binders, and defoamers.

[0019] The specific formulations of the herbicidal composition are dispersible oil suspensions, aqueous suspensions, emulsions, wettable powders, emulsifiable concentrates, water-dispersible granules (dry suspensions), water emulsions, and microemulsions.

[0020] In short, the compositions of the present invention can be mixed with solid and liquid additives conventionally used in existing formulations. The amount of active ingredient used varies with changing external conditions, such as temperature, humidity, and the nature of the herbicide used. It can vary considerably, for example, from 0.001 to 1.0 kg / ha, or more active substances, but is preferably between 0.005 and 750 g / ha, particularly between 0.005 and 500 g / ha.

[0021] In addition, the composition of the present invention can be applied to the leaves of the plant to be treated by spraying, i.e., applied to weeds, especially to surfaces that are infested or susceptible to weed infestation.

[0022] Furthermore, the present invention also provides an application of the herbicidal composition in controlling weeds; and a method for controlling unwanted plant growth, comprising applying the herbicidal composition to plants, plant parts, plant seeds, or areas where plants grow. Preferably, the herbicidal composition is used to selectively control weeds in useful crops; more preferably, the useful crop is a transgenic crop or a crop treated with genome editing technology.

[0023] The compounds of this invention can be used to treat all plants and plant parts. Plant varieties and cultivars can be obtained through conventional propagation and breeding methods or through genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgenic gene) has been stably integrated into the plant's genome. The transgenic event defined by its specific location in the plant genome is called a transformation event or transgenic event.

[0024] Genetically modified plant cultivars that can be treated according to the present invention include those resistant to one or more biotic stresses (pests, such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, low temperature, soil salinization, etc.), or those containing other desired traits. Plants can be genetically modified to express traits such as herbicide tolerance, insect tolerance, modified oil characteristics, or drought tolerance. Information on available genetically modified plants containing single gene transformation events or combinations of transformation events is available, for example, from publicly available databases maintained by the U.S. Department of Agriculture.

[0025] When the herbicidal compositions of the present invention are applied, their herbicidal activity exhibits unexpected synergistic effects relative to single agents and any binary combinations thereof. These synergistic effects manifest as reduced application rates, a broader spectrum of weed control, faster and more sustained weed control—characteristics desired in weed control practices. In terms of the described properties, these new compositions are significantly superior to existing herbicides, achieving reduced application rates and being more environmentally friendly.

[0026] The synergistic herbicidal composition of the present invention also has the following advantages:

[0027] (1) The compositions of the present invention are environmentally friendly and are easily degraded in the environment.

[0028] (2) The herbicide composition of the present invention is low in cost and easy to use, and its promotion and application have great economic and social benefits. Detailed Implementation

[0029] The following examples are not intended to limit the invention, but are merely illustrative of how the invention is implemented. These examples demonstrate particularly significant effectiveness against certain weeds. Examples are as follows:

[0030] Pharmacological trials

[0031] 1) Experimental targets: black nightshade, speedwell, and shepherd's purse.

[0032] 2) Reagents: The original drug was diluted with acetone as solvent and diluted with a 0.1% Tween-80 emulsifier aqueous solution. It was diluted immediately before use.

[0033] 3) Experimental method (post-emergence foliar spraying treatment): Weeds were cultivated in pots. When Veronica had 4-6 leaves, Desmodium had 5-6 cm, and Solanum nigrum had 4-5 leaves, the foliar spraying was applied evenly, with a spray volume of 450 kg / ha.

[0034] 4) Data survey and statistical analysis

[0035] 4.1) Survey Methods

[0036] The absolute number method was used. Surviving weed seedlings were cut along the soil surface with a blade, and their fresh weight was measured using an analytical balance. Dead weeds were counted as having a fresh weight of zero.

[0037] 4.2) Survey time and frequency

[0038] An investigation was conducted 20 or 26 days after treatment, for a total of one investigation.

[0039] 4.3) Data Statistical Analysis

[0040] Use the Colby test to evaluate the combined effects of any two or three of these agents on weeds.

[0041] Aboveground green tissue was collected from each treatment area and weighed using an electronic balance. The actual survival rate was calculated as follows: E(%) = (fresh weight of weeds in the treatment area / fresh weight of weeds in the control area) × 100

[0042] The theoretical weed survival rate calculation formula is: E0(%) = X × Y / 100 (binary mixture)

[0043] In the formula, X represents the weed survival rate of A when the dosage is P, Y represents the weed survival rate of B when the dosage is Q, E0 represents the theoretical weed survival rate of A+B when the dosage is (P+Q), and E represents the actual weed survival rate of each treatment.

[0044] E0(%)=X×Y×Z×…×N / 100 (n-1) (Mixed use of ternary or higher-grade compounds)

[0045] In the formula, X, Y, Z, and N represent the actual survival rates of n single agents, and n is the number of compound herbicides.

[0046] When E0-E > 10%, it indicates a synergistic effect; when E0-E < -10%, it indicates an antagonistic effect; when E0-E is between ±10%, it indicates an additive effect.

[0047] The statistical results of the actual control efficacy and combined effect evaluation of each component in weed control are shown in Table 1-3 below.

[0048] Table 1A is... B is fluroxypyridine, C is bispyribac-methyl, and the weed is Veronica persica (20D).

[0049] Table 2A is... B is isooctyl clopyralid, C is dimethyltetrachloroisooctyl ester, and the weed is black nightshade (26D).

[0050] Table 3A is... B is isooctyl clopyralid, C is bispyribac-methyl, and the weed is shepherd's purse (26D). Note: E(A): Measured fresh weight survival rate of component A at a given dose; E(B): Measured fresh weight survival rate of component B at a given dose; E(C): Measured fresh weight survival rate of component C at a given dose; E(A+B): Measured fresh weight survival rate of a binary mixture of components A and B at a given dose; E(A+C): Measured fresh weight survival rate of a binary mixture of components A and C at a given dose; E(B+C): Measured fresh weight survival rate of a binary mixture of components B and C at a given dose; E(A+B+C): Measured fresh weight survival rate of a binary mixture of components B and C at a given dose; E(A+B+C): Measured fresh weight survival rate of a binary mixture of components A and C at a given dose; Measured fresh weight survival rate E0(A+B+C) of ternary mixtures of components A, B, and C: E0((A+B)+C) at a given dose; E0((A+B)+C) at a given dose; E0((A+C)+B) at a given dose; E0(A+(B+C)) at a given dose; E0(A+(B+C)) at a given dose; E0(A+C) at a given dose; E0(A+(B+C)) at a given dose; E0(A+C) at a given dose; E0(A+C) at a given dose; E0(B+C) at a given dose; E0(A ...B+C) at a given dose; E0(A+C) at a given dose; E0(A+B+C) at a given dose; E0(A+C) at a given dose; E0(A+B+C) at a given dose; E0(A+B+C) at a given dose; E0(A+B+C) at a given dose; E0(A+B+C) at a given dose; E0(A+B+C) at a given dose; E0(A+B+C)

[0051] Through extensive experimentation and exploration, this invention has unexpectedly discovered that the composition exhibits a surprising and unexpected synergistic effect in controlling various grass and broadleaf weeds. This synergistic effect is more pronounced at low doses, which can reduce the amount of pesticide used, reduce environmental pollution, and the rational compounding reduces agricultural costs, showing great application potential.

Claims

1. A ternary herbicidal composition, characterized by comprising: Comprising an effective amount of herbicidal active ingredient A, active ingredient B and active ingredient C, wherein, Active ingredient A is Active ingredient B is flurochloridone or isooctyl fluroxypyr; Active ingredient C is isopyrazam or isooctyl MCPA.

2. The ternary herbicidal composition according to claim 1, characterized by Wherein, The weight ratio of A, B and C is 0.1 - 30:0.1 - 100:1 - 200, 0.5 - 10:0.5 - 80:3 - 150, 0.7 - 8:0.8 - 60:5 - 100, 0.8 - 5:1 - 20:10 - 60, 1 - 4:2 - 15:15 - 40 or 2 - 3:3 - 4:20 - 25.

3. The ternary herbicidal composition according to claim 1 or 2, characterized by The mass percentage content of A, B and C in the herbicidal composition accounts for 1 - 95% of the total amount, preferably 10 - 80%.

4. The ternary herbicidal composition according to claim 1 or 2, characterized by The herbicidal composition further comprises conventional auxiliaries. Preferably, the conventional auxiliaries include carriers and / or surfactants.

5. The ternary herbicidal composition according to claim 1 or 2, characterized by, The herbicidal composition further comprises at least one safener. Preferably, the safener is selected from one or more of isoxadifen - ethyl, cyprosulfamide, pyraclonil, cloquintocet - mexyl, gibberellic acid, furilazole, metcamifen.

6. The ternary herbicidal composition according to any one of claims 1 to 5, characterized in that, The specific formulation of the herbicidal composition is a dispersible oil suspension, a water suspension, a suspo - emulsion, a wettable powder, an emulsifiable concentrate, a water - dispersible granule, an emulsion in water or a microemulsion.

7. Use of the ternary herbicidal composition according to any one of claims 1 - 6 in controlling weeds. Preferably, the herbicidal composition is used for selectively controlling weeds in useful crops. More preferably, the useful crops are genetically modified crops or crops treated by genome editing techniques.

8. A method for controlling unwanted plant growth, which comprises applying the ternary herbicidal composition according to any one of claims 1 - 6 to plants, plant parts, plant seeds or the areas where plants grow. Preferably, the herbicidal composition is used for selectively controlling weeds in useful crops. More preferably, the useful crops are genetically modified crops or crops treated by genome editing techniques.

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