A herbicidal composition containing fluroxypyr, metamifop and isoxaben and its use

Abstract

This invention provides a herbicidal composition comprising the active ingredients chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole, wherein the mass ratio of chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole is 1~3:15~20:10~15. The herbicidal composition has a significant synergistic effect and can effectively solve the problem of weed resistance.

Description

Technical Field

[0001] This invention belongs to the field of herbicides, specifically relating to a herbicidal composition containing chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole and its application. Background Technology

[0002] chloropyridinium chloride is a novel arylpyridylcarboxylate herbicide that mimics the action of plant growth hormones (such as indoleacetic acid), binding to the receptor protein AFB5 to induce excessive cell division and uncontrolled growth, ultimately leading to weed death. Its site of action differs from traditional hormone-based herbicides (such as 2,4-D), therefore it exhibits no cross-resistance with existing herbicides. Chlorpyridinium chloride offers advantages in high efficiency, broad spectrum, low residue, and resistance management, effectively controlling noxious weeds such as barnyard grass, Echinochloa crus-galli, Monochoria divaricata, and Cyperus difformis in rice and wheat fields.

[0003] Oxazolam is a selective aryloxyphenoxypropionic acid (APP) herbicide. It inhibits acetyl-CoA carboxylase (ACCase) in weeds, thereby hindering fatty acid synthesis, disrupting cell membrane structure, causing leaf chlorosis and wilting, and ultimately leading to the death of the entire plant. It is highly safe for rice and can effectively control resistant gramineous weeds in rice fields.

[0004] Isoxaben is a selective isoxazole herbicide that works by inhibiting cellulose synthesis in weeds. It is highly effective against a variety of broadleaf weeds and has no cross-resistance with common herbicides. It is widely used in dryland fields such as soybeans, sugarcane, and cotton, as well as some rice fields (direct-seeded).

[0005] Long-term use of a single herbicide leads to a continuous increase in weed resistance. In recent years, the resistance of noxious weeds such as barnyard grass and Echinochloa crus-galli has been increasing, and single herbicides can no longer meet the control needs. Compound herbicides can improve efficacy while reducing the dosage through synergistic effects, effectively solving the resistance problem and slowing down the development of weed resistance.

[0006] Chinese patent CN104661518A discloses a synergistic herbicidal composition comprising chlorpyrifos and isoxaflutole (i.e., isoxaflutole) for weed control in rice paddies. Chinese patent CN106106466A discloses a rice paddy weed control composition containing oxadiazon and isoxaflutole for controlling most grasses and broadleaf weeds in rice paddies. Chinese patent CN106719675A discloses a rice paddy weed control composition comprising chlorpyrifos and oxadiazon for controlling annual weeds in rice paddies. Although binary compositions of chlorpyrifos, oxadiazon, and isoxaflutole have been disclosed in pairs, providing inspiration for ternary compositions of chlorpyrifos, oxadiazon, and isoxaflutole, the synergistic ratio range and optimal synergistic ratio of these ternary compositions remain unpredictable.

[0007] Chinese patent CN107751212A discloses a ternary herbicide composition for paddy fields, comprising active ingredients A, B, and C. Active ingredient A is oxazolidinyl, B is either cyhalofop-butyl or isoxaflutole, and C is chlorpyrifos. This composition exhibits a synergistic effect, with the most significant synergistic effect observed when the mass ratio of A, B, and C is 10:6:3. It is used to control annual weeds in paddy fields. However, the authenticity of the data in this patent is questionable. The data in the specification is insufficient to support the claim that a synergistic effect truly exists among the components. Furthermore, the efficacy data of the composition at the 10:6:3 ratio is not of practical significance. In other words, the document merely discloses that oxazolidinyl, isoxaflutole, and chlorpyrifos can be mixed for use, without clarifying whether they have a synergistic effect, nor determining the range or optimal synergistic ratio. Summary of the Invention

[0008] Based on the above, the purpose of this invention is to provide a herbicidal composition containing chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole, and to determine its synergistic ratio range and optimal synergistic ratio. Within this ratio range, the herbicidal composition has a significant synergistic effect. When used to control weeds in paddy fields, it can improve efficacy, reduce dosage, and also solve the problem of weed resistance.

[0009] The technical solution of the present invention is as follows: A herbicidal composition comprising the active ingredients chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole, wherein the mass ratio of chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole is 1~3:15~20:10~15.

[0010] Preferably, the mass ratio of chlorpyrifos, oxazolidinyl acetonide, and isoxaflutole is 1.2:17.8:12.

[0011] The herbicidal composition of the present invention is used for controlling weeds in paddy fields.

[0012] Preferably, the paddy field weeds include barnyard grass, Echinochloa crus-galli, Crataegus pinnatifida, Cyperus difformis, and Monochoria vaginalis.

[0013] The beneficial effects of this invention are: 1. This invention determines the synergistic ratio range of the herbicidal composition of chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole.

[0014] 2. This invention has determined the optimal synergistic ratio of the herbicidal composition of chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole.

[0015] 3. The herbicidal composition of chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole provided by the present invention can solve the problem of weed resistance in paddy fields. Detailed Implementation

[0016] To enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below with reference to specific embodiments. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0017] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0018] Unless otherwise specified, all raw materials and reagents used in the following examples are commercially available.

[0019] I. Indoor toxicity test Test target: barnyard grass ( Echinochloa crus-galli ).

[0020] Experimental Method: Soil was quantitatively filled to 4 / 5 of the experimental pots, and the soil was thoroughly moistened by bottom irrigation. Seeds of the tested weeds were sown on the soil surface, covered with 0.5 cm of soil, and then transferred to a greenhouse for routine cultivation, maintaining a uniform weed density in each pot. Based on the preliminary experimental results, pesticide solutions were prepared and applied as foliar sprays at the 1-2 leaf stage of the weeds. The fresh weight of the weeds in each treatment was assessed 21 days after application, and the control efficacy was calculated using the following formula:

[0021] In the formula: E represents the fresh weight efficacy; C represents the fresh weight of the control aboveground parts; and T represents the fresh weight of the treated aboveground parts.

[0022] The herbicidal efficacy of a combination of three active ingredients—chlorpyrifos, oxazolidinyl, and isoxaflutole—was evaluated using the Colby method. The evaluation method is as follows: E0 = 100 - (X × Y × Z / 100) (n-1) ) In the formula: E0 is the theoretical fresh weight inhibition rate of the mixed herbicide against the tested weeds; X is the ratio of the fresh weight of weeds to the fresh weight of the control weeds when chlorpyrifos is used alone; Y is the ratio of the fresh weight of weeds to the fresh weight of the control weeds when oxazolidinone is used alone; Z is the ratio of the fresh weight of weeds to the fresh weight of the control weeds when isoxaflutole is used alone; n is the amount of active ingredient.

[0023] E represents the measured inhibition rate of the three herbicides on the fresh weight of the tested weeds. When E - E0 > 10%, it is a synergistic effect; when -10% ≤ E - E0 ≤ 10%, it is an additive effect; and when E - E0 < -10%, it is an antagonistic effect.

[0024] As shown in the table below, when the mass ratio of chlorpyrifos, oxazolidinyl, and isoxaflutole is 1:10:10, the synergistic effect on barnyardgrass is 5.71%, indicating that the ternary combination exhibits an additive effect. The synergistic effect coefficients of the other treatments on barnyardgrass are all greater than 10%, showing a synergistic effect. Among them, when the mass ratio of chlorpyrifos, oxazolidinyl, and isoxaflutole is 1.2:17.8:12, the synergistic effect coefficient is the highest, reaching 19.63%, which is the most significant and superior to the binary combination treatments.

[0025] Table 1. Results of toxicity tests on barnyardgrass with different ratios of chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole.

[0026] The above results indicate that the ternary composition containing chlorpyrifos, oxazolidinyl acetamiprid, and isoxaflutole provided by the present invention has a synergistic effect, and the synergistic effect is most obvious when the mass ratio of the three is 1.2:17.8:12, which can improve the control efficacy and slow down the occurrence of resistance.

[0027] II. Formulation Examples Example 1 Chloropyridine ester, 1.2%; Oxazolidinone, 17.8%; Isoxamethasone, 12%; Styrene-based phenolic polyoxyethylene ether, 5%; Fatty alcohol polyoxyethylene ether, 3%; Sodium dodecylbenzenesulfonate, 5%; BHT antioxidant, 0.1%; Citric acid, 0.2%; Cyclohexanone, 8%; N-methylpyrrolidone, 12%; Make up the xylene to 100%.

[0028] Example 2 chloropyridine ester, 1%; Oxazolidinone, 15%; Isoxaflutole, 10%; Styrene-based phenolic polyoxyethylene ether, 5%; Fatty alcohol polyoxyethylene ether, 3%; Sodium dodecylbenzenesulfonate, 5%; BHT antioxidant, 0.1%; Citric acid, 0.2%; Cyclohexanone, 8%; N-methylpyrrolidone, 12%; To bring the xylene content to 100%.

[0029] Example 3 chloropyridinium ester, 3%; Oxazolidinone, 10%; Isoxaflutole, 6%; Styrene-based phenolic polyoxyethylene ether, 5%; Fatty alcohol polyoxyethylene ether, 3%; Sodium dodecylbenzenesulfonate, 5%; BHT antioxidant, 0.1%; Citric acid, 0.2%; Cyclohexanone, 8%; N-methylpyrrolidone, 12%; To bring the xylene content to 100%.

[0030] The above raw materials were placed in a reaction vessel in the formula ratio, stirred and mixed, and filtered to obtain a chlorpyrifos·oxazolidinyl ester·isoxamethonium emulsifiable concentrate formulation.

[0031] Although embodiments of the invention have been disclosed for illustrative purposes, those skilled in the art will understand that various substitutions, variations, and modifications are possible without departing from the spirit and scope of the invention and the appended claims, and therefore the scope of the invention is not limited to the contents disclosed in the embodiments.

Claims

1. A herbicidal composition, characterized in that, The composition comprises the active ingredients chlorpyrifos, oxazolidinyl acetonide, and isoxaflutole, and the mass ratio of chlorpyrifos, oxazolidinyl acetonide, and isoxaflutole is 1~3:15~20:10~15.

2. The herbicidal composition according to claim 1, characterized in that, The mass ratio of chlorpyrifos, oxazolidinyl acetonide, and isoxaflutole is 1.2:17.8:

12.

3. Use of the herbicidal composition as described in any one of claims 1 or 2 for controlling weeds in paddy fields.

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