Samples Introduction/Extraction TRIZ Cases

Reducing pressure inside the sealed vessel increases sample gas density for efficient ionization, eliminating heating requirements and minimizing carry-over.

Spatially segmenting tissue via droplet lysis reduces abundant molecule interference, enhancing mass spectrometry sensitivity for specific biomarkers.

Segmenting ion flow through parallel capillaries reduces space charge effects and wall collisions, enabling gas-dynamic focusing.

An asymmetric sample cone and tapered internal surface reduce transience time, maintaining plume distinctiveness during mass spectrometry analysis.

Extreme ultraviolet radiation disrupts and ionizes surface residues, eliminating bulky desorbers and ozone generation in trace detection systems.

An ion trap separates reference ions from analyte ions to prevent signal suppression and maintain calibration accuracy.

A heated channel generates charged particles from samples without electric fields, reducing system complexity and ion losses.

Rapid thermal pyrolysis achieves site-specific protein digestion at aspartic acid positions, bypassing slow enzymatic incubation and complex instrumentation.

Replacing stepper motor syringe pumps with pneumatic pressure eliminates flow oscillations, ensuring stable aerosol generation for low volatility compounds.

Segmenting continuous flow into picoliter droplets maintains measurement sensitivity during high-throughput analysis.

Capacitive coupling generates aerosols through an insulating substrate, enabling optical imaging without direct electrical contact or sample contamination.

Applying an asymmetric voltage waveform to a linear ion trap radially separates ions by differential mobility, eliminating diffusion losses at reduced pressure.

Laserspray ionization produces multiply-charged ions at atmospheric pressure for mass spectrometry analysis.

An auto-sampling system uses three independent syringes and a valve network to dynamically introduce carrier, diluent, and stock matrix flows for precise fluid management.

A sputter neutral particle mass spectrometry apparatus uses a concave mirror to redirect a light beam through the adjacent region for photoionization.

Annealing drives hydrophobic additives to polymer slide surfaces, stabilizing MALDI target performance against additive migration.

Direct surface desorption ionization eliminates chromatographic separation steps to accelerate product authentication analysis.

A sample chamber purge conduit collects heavier atmospheric gases from the lowermost region using a lighter carrier gas flow.

A regulator held by a movable holder shifts between measurement and non-measurement positions to simplify gas container handling.

Femtosecond laser pulses ionize samples at ambient pressure, enhancing universality while reducing fragmentation.

Liquid bridge transfers soluble analytes to a sample site, separating them from insoluble residues to enable homogeneous matrix crystallization.

Segmented wells and gas channels increase sample throughput while maintaining sensitivity and reducing contamination.

Nested ceramic tubes with high resistivity ground the electrospray nebulizer, eliminating electrical shock risks while preserving ion introduction efficiency.

A conveyor-based trace sampling system uses localized heating to evaporate substances directly from items moving along the belt.

Acoustic energy ejects liquid sample droplets from a solid surface into a gas stream for direct transport.

Electrokinetic pumps replace mechanical baffles with solid-state switching, eliminating failure points and enhancing mass accuracy.

A fixed geometry ambient ionisation source unit integrates the generation device and sampling inlet within a single housing.

Parallel ion channels increase duty cycle by resolving quadrupole scanning limitations.

Differential heating in a sampling inlet vapourises low vapour pressure aerosols, resolving detection sensitivity limits in ion mobility spectrometers.

A molecule collector aggregates organic contaminants for mass spectrometer analysis to determine vacuum chamber cleanliness levels.

An acoustic droplet generator eliminates surface contact and memory effects by entraining monodisperse droplets in a gas stream for direct analysis.

Removable ion source extracts through interlock valve to maintain vacuum integrity and reduce downtime.

Image analysis adjusts probe-to-surface distance to maintain optimal liquid microjunction thickness during automated surface sampling.

A bubble plasma ionisation probe generates gas phase ions at the gas-liquid interface for direct mass spectrometric detection.

Etched solid support surfaces create uniform nucleation sites for matrix crystallization, reducing site-to-site variability in MALDI mass spectrometry imaging.

Backside gas pulses or piezo strikes ionize analytes, resolving precision and complexity trade-offs in mass spectrometry imaging.

Solvent probe captures laser ablation plume to achieve fifty percent transfer efficiency and reduce sample loss during ambient mass spectrometry.

Separate reagent ion sources feed a reaction chamber to mix analytes, resolving detection time and adduct interference bottlenecks.

Segmented ionization stages in the multimethod device reduce detection time while maintaining sensitivity for trace-level substance identification.

Replacing non-volatile buffer salts with volatile alternatives eliminates ion suppression, increasing analyte signal intensity and signal-to-noise ratio.

A mass spectrometer ion introduction opening uses optimized pressure to maintain high detection sensitivity.

An adsorbent coating on the skimmer cone traps deposited matter, preventing memory effects and maintaining ICP-MS throughput.

Segmenting gas supply isolates filtration to carrier lines, reducing background noise and extending filter life without increasing device complexity.

A mass-selective isotope implantation system pre-concentrates target isotopes on a high-purity substrate.

Eliminates laser and high voltage requirements by utilizing spontaneous matrix-assisted ionization vacuum to analyze fragile molecules.

A liquid extraction MALDI ion source forms a junction to extract analytes and uses laser desorption for mass spectrometry analysis.

A multimethod ionization device segments reagent ions into parallel chemical, photo, and corona discharge zones to accelerate analyte adduct formation.

Mechanical agitation separates biological samples on a target surface, reducing mass spectral peak broadening and improving mass accuracy.

Pneumatic cooling reduces probe temperature from 500°C, cutting waiting time and increasing analysis throughput.

Rotating moveable components generate axial force for fluid-tight seals, eliminating damage risks during insertion and reducing maintenance downtime.