A simultaneous response to ClO - Tetraphenylethylene-aromatic ring hybrid fluorescent probes with varying viscosity, their preparation methods, and applications

By designing a fluorescent probe based on a tetraphenylethylene-aromatic ring hybrid structure, a dual-response detection of ClO- and cell viscosity was achieved, solving the problem of early diagnosis of atherosclerosis and providing a detection tool with high sensitivity and high spatiotemporal resolution.

CN116874462BActive Publication Date: 2026-01-30THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIVERSITY +1
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Patent Information

Application Number
CN202310848441.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-07-11
Publication Date
2026-01-30
Estimated Expiration
2043-07-11

AI Technical Summary

Technical Problem

Existing fluorescent probe technologies cannot accurately detect changes in hypochlorous acid and cell viscosity in the early stages of atherosclerosis, causing patients to miss the optimal treatment time. Furthermore, there is a lack of fluorescent probes that can respond to both ClO- and viscosity changes simultaneously.

Method used

A fluorescent probe based on a tetraphenylethylene-aromatic ring hybrid structure was designed. By introducing dinitrile isoflavone and diaminomaleitrile, it achieves specific recognition of ClO-. The tetraphenylethylene is used as a molecular rotor to respond to changes in cell viscosity. The synthetic route includes condensation, coupling and Knoevenagel condensation reactions.

Benefits of technology

This probe can rapidly and sensitively detect changes in ClO- levels and cell viscosity, has good cell membrane permeability, can provide a diagnostic tool in the early stages of atherosclerosis, and is simple, safe, and readily available in synthesis.

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Abstract

This invention belongs to the field of fluorescent probes and discloses a probe that can simultaneously respond to ClO ‑ Tetraphenylethylene-thiophene hybrid fluorescent probes with varying viscosity and their preparation methods and applications. The probes utilize a tetraphenylethylene-aromatic ring hybrid structure as the chromophore, with dinitrile isophorone and diaminomaleitrile as ClO₂ groups, respectively. ‑ Based on the recognition group, fluorescent probe molecules were designed and synthesized, with the following general structural formula: This type of fluorescent probe is effective against ClO₂. ‑ It exhibits rapid response, high specificity, and high sensitivity, with a strong responsiveness to viscosity, and can simultaneously detect ClO. ‑ Changes in viscosity levels and the environment provide new insights and potential detection tools for the early diagnosis of atherosclerosis.
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