A fungicidal composition containing feneptamidoquin and its use

Abstract

The application belongs to the technical field of pesticide fungicide, and discloses a fungicide composition containing feneptamidoquin and application thereof, wherein the active ingredient A is feneptamidoquin, the active ingredient B is any one of fluazinam or boscalid, and the mass ratio of the active ingredient A to the active ingredient B is 1:27-30:1.The fungicide composition has good control effect, has a synergistic effect on the prevention and treatment of plant fungal diseases, can effectively control the drug resistance of pathogenic microorganisms, reduces the amount of pesticide, and is friendly to the environment.

Description

Technical Field

[0001] This invention relates to the field of pesticide compound compositions, specifically to a fungicide composition containing feneptamidoquin and its application. Background Technology

[0002] Gray mold is a common disease in cucumber cultivation, severely impacting cucumber quality and yield. *Botrytis cinerea* is a common pathogen causing gray mold. It can damage cucumber flowers, leaves, fruits, and stems. It typically first infects withered male flowers, causing them to rot and develop a grayish-brown mold layer. As the disease progresses, it spreads to young fruits, which gradually become water-soaked and begin to rot. Later, a large amount of grayish-brown mold appears on the rotten parts.

[0003] Fluopyram is an SDHI fungicide that can be used on grains, soybeans, corn, vegetables, fruits, and cash crops for disease control through foliar or seed treatment. Fluopyram works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, thereby inhibiting the germination of spores, germ tubes, and mycelial growth of target fungi.

[0004] Boscalid is a nicotinamide fungicide mainly used to control powdery mildew, gray mold, various rot diseases, brown rot, and root rot. Boscalid is an inhibitor of succinate-coenzyme Q reductase in the mitochondrial respiratory chain, which has a strong inhibitory effect on spore germination and does not exhibit cross-resistance with other fungicides.

[0005] Long-term use of single chemical pesticides easily leads to resistance problems, resulting in continuously increasing pesticide dosages, increased risk of resistance, and harm to environmental and ecological safety. Seeking scientific and rational pesticide combinations is a better way to solve this problem. Through pesticide screening and indoor and field trials, the applicant has conducted in-depth research on feneptamidoquin in combination with fluopyram or boscalid, and their combinations. The research found that feneptamidoquin, when combined with any one of fluopyram or boscalid, exhibits a significant synergistic effect within a certain proportion range. Furthermore, the mechanisms of action of feneptamidoquin and fluopyram or boscalid are significantly different, expanding the application range of the pesticides, reducing dosage, delaying the emergence and development of pesticide resistance in pathogens, and being environmentally friendly. Summary of the Invention

[0006] Based on the above, the purpose of this invention is to provide a fungicide composition containing feneptamidoquin, which can be used to prevent and control fungal diseases, especially effective against cucumber gray mold, reducing the amount of pesticide used while delaying the development and growth of drug resistance in pathogens, and is environmentally friendly.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: a bactericidal composition containing feneptamidoquin, wherein the bactericidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is feneptamidoquin, and active ingredient B is either fluopyram or cyazofamid, and the mass ratio of active ingredient A to active ingredient B is 1:27 to 30:1, or any value within the above range.

[0008] Furthermore, the active ingredient B is fluopyram, and the mass ratio of the active ingredient A to the active ingredient B is 1:20 to 30:1, or any value within the above range.

[0009] The active ingredient B is cyazofamid, and the mass ratio of active ingredient A to active ingredient B is 1:27 to 21:1, or any value within the above range.

[0010] Furthermore, the active ingredient B is fluopyram, and the mass ratio of the active ingredient A to the active ingredient B is 1:15 to 25:1, or any value within the above range.

[0011] The active ingredient B is cyazofamid, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 12:1, or any value within the above range.

[0012] Furthermore, based on the total weight of the bactericidal composition of 100 wt%, the total weight of active ingredient A and active ingredient B accounts for 0.1% to 80% of the total weight of the bactericidal composition, preferably 1% to 70%.

[0013] Furthermore, in addition to the active ingredient, the bactericidal composition also includes agriculturally permissible auxiliary ingredients, which are selected from one or more of wetting agents, dispersants, thickeners, disintegrants, emulsifiers, defoamers, preservatives, stabilizers, synergists, carriers, and solvents.

[0014] Furthermore, in addition to the active ingredient, the bactericidal composition also includes agriculturally permissible auxiliary ingredients, which are selected from one or more of wetting agents, dispersants, thickeners, disintegrants, emulsifiers, defoamers, preservatives, stabilizers, synergists, carriers, and solvents.

[0015] The wetting agent is selected from one or more of the following: alkylbenzene sulfonates, alkylnaphthalene sulfonates, lignin sulfonates, sodium dodecyl sulfate, sodium dioctyl succinate sulfonate, α-olefin sulfonates, alkylphenol polyoxyethylene ethers, castor oil polyoxyethylene ethers, alkylphenol ethoxylates, sodium fatty alcohol polyoxyethylene ether sulfate, silkworm excrement, soapberry powder, soapberry powder, SOPA, detergents, emulsifiers 2000 series, and wetting and penetrating agents F; and / or

[0016] The dispersant is selected from one or more of the following: lignin sulfonate, alkyl naphthalene sulfonate formaldehyde condensate, naphthalene sulfonate, tristyrylphenol ethoxylate phosphate, fatty alcohol ethoxylate, alkylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether methyl ether condensate sulfate, fatty amine polyoxyethylene ether, glycerol fatty acid ester polyoxyethylene ether, polycarboxylates, polyacrylic acids, phosphates, EO-PO block copolymers, and EO-PO graft copolymers; and / or

[0017] The thickener is selected from one or more of xanthan gum, polyvinyl alcohol, organobentonite, magnesium aluminum silicate, and carboxymethyl cellulose; and / or

[0018] The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid, and tartaric acid; and / or

[0019] The emulsifier is selected from one or more of the following: fatty alcohol polyoxyethylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, phenethylphenol polyoxyethylene polyoxypropylene ether, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, alkylbenzene sulfonate, styrene-phenol polyoxyethylene ether, and fatty acid polyoxyethylene ester; and / or

[0020] The defoamer is selected from silicone oil, C 10 ~C 20 Saturated fatty acid compounds, C8-C 10 One or more of fatty alcohols or silicone compounds; and / or

[0021] The preservative is selected from one or more of sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, and methyl p-hydroxybenzoate; and / or

[0022] The stabilizer is selected from one or more of the following: acid, succinic acid, adipic acid, borax, and epoxidized vegetable oil; and / or

[0023] The synergist is selected from synergistic phosphorus, synergistic ether; and / or

[0024] The carrier is selected from one or more of kaolin, bentonite, attapulgite, light calcium carbonate, diatomaceous earth, and precipitated silica; and / or

[0025] The solvent is selected from one or more of benzene, toluene, xylene, methanol, ethanol, isopropanol, n-butanol, diesel oil, N,N-dimethylformamide, cyclohexanone, ethyl acetate, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, solvent oil, vegetable oil, vegetable oil derivatives, and deionized water; and / or

[0026] Furthermore, the bactericidal composition can be prepared into any agriculturally permissible formulation.

[0027] Furthermore, the dosage form is a solid dosage form or a liquid dosage form;

[0028] Furthermore, the solid dosage form is a direct-use solid dosage form, a dispersible solid dosage form, or a soluble solid dosage form;

[0029] Furthermore, the directly usable solid dosage form is a powder, granule, ball, tablet, or strip;

[0030] The dispersible solid dosage form is a wettable powder, an oil-dispersible powder, an emulsion powder, a water-dispersible granule, an emulsion granule, or a water-dispersible tablet;

[0031] The soluble solid dosage form is a soluble powder, soluble tablet, or soluble granule;

[0032] Furthermore, the liquid formulation is a solution formulation, a dispersed liquid formulation, an emulsion formulation, a suspension formulation, or a multiphase formulation;

[0033] Furthermore, the solution formulation is a soluble agent, a soluble gel, an oil, or a film-spreading oil;

[0034] The dispersed liquid formulation is an emulsifiable concentrate, latex, dispersible liquid, or ointment;

[0035] The emulsion formulation is an aqueous emulsion, an oil emulsion, a microemulsion, or a lipid formulation;

[0036] The suspension formulation is a suspension agent, microcapsule suspension agent, oil suspension agent, or dispersible oil suspension agent;

[0037] The multiphase formulation is a suspension emulsion, a microcapsule suspension-suspension, a microcapsule suspension-water emulsion, or a microcapsule suspension-suspension emulsion;

[0038] Preferably, the solid formulation is a wettable powder and / or a water-dispersible granule, and the liquid formulation is a suspension concentrate and / or an emulsifiable concentrate.

[0039] The present invention also discloses the application of the fungicidal composition and / or its formulation as described above in the prevention and control of fungal diseases in plants.

[0040] Furthermore, the aforementioned plant fungal diseases include one or more of gray mold, powdery mildew, anthracnose, sheath blight, rust, and rice blast;

[0041] Furthermore, the plant fungal disease mentioned is gray mold.

[0042] Furthermore, the bactericidal composition is applied in an effective dose to the disease or its growth medium that needs to be controlled.

[0043] Compared with the prior art, the beneficial effects of the technical solution of the present invention are as follows:

[0044] 1) The bactericidal composition of the present invention has a significant synergistic effect on gray mold in cucumbers;

[0045] 2) The bactericidal composition of the present invention reduces the amount of agent used and the number of times it is applied, thereby reducing the cost of prevention and control;

[0046] 3) The bactericidal composition of the present invention can effectively control the development of drug resistance in pathogenic microorganisms and extend the service life of the drug. Detailed Implementation

[0047] To make the technical solution, objectives and advantages of the present invention clearer, the present invention is described with reference to the following specific embodiments. However, the present invention can be implemented in various forms and should not be limited to the embodiments described herein.

[0048] Formulation preparation example:

[0049] Preparation Example 1: 24% feneptamidoquin·fluopyram suspension (5:1) (20% + 4%)

[0050] Formula composition: feneptamidoquin 20%, fluopyram 4%, phenethylphenol polyoxyethylene polyoxypropylene ether 3%, glycerol fatty acid ester polyoxyethylene ether phosphate 3%, lignosulfonate 2%, magnesium aluminum silicate 1%, xanthan gum 0.25%, sodium benzoate 1%, silicone oil 0.5%, ethylene glycol 5%, deionized water to make up the balance.

[0051] Preparation method: Water, dispersant, and wetting agent are mixed evenly. Defoamer and antifreeze are added sequentially under stirring. The mixture is then mixed evenly by high-speed shearing. Feneptamidoquin and fluopyram are added, and the mixture is further sheared and mixed evenly. The mixture is then ground in a horizontal sand mill, and the particle size of the material is controlled to be below 90% of 5 μm. Finally, a thickener is added, and the mixture is sheared evenly to obtain the suspension agent described in this invention.

[0052] Preparation Example 2: 8% feneptamidoquin·fluopyram EC (1:7) (1% + 7%)

[0053] Formula composition: feneptamidoquin 1%, fluopyram 7%, N,N-dimethylformamide 15%, cyclohexanone 20%, castor oil polyoxyethylene ether 12%, calcium dodecylbenzenesulfonate 3%, xylene to make up the balance.

[0054] Preparation method: Dissolve the active ingredient feneptamidoquin and fluopyram in an organic solvent according to the formula ratio, then add a certain amount of emulsifier, and mix by stirring to prepare a homogeneous and transparent oily liquid.

[0055] Preparation Example 3: 39% feneptamidoquin·fluopyram water-dispersible granules (12:1) (36% + 3%)

[0056] Formula composition: feneptamidoquin 36%, fluopyram 3%, succinate sulfonate 10%, BX 2.5%, sodium lignin sulfonate 6%, white sugar 6%, kaolin to make up the balance.

[0057] Preparation method: The active ingredients feneptamidoquin and fluopyram are added to the carrier, along with surfactants and other functional additives. The mixture is then pulverized by air jet milling, and 10-25% water is added. The mixture is then kneaded, granulated, dried, and sieved to obtain the water-dispersible granule product.

[0058] Preparation Example 4: 16% feneptamidoquin·cyprodinil suspension (1:3) (4% + 12%)

[0059] Formula composition: feneptamidoquin 4%, cymoxanil 12%, sorbitan oleate polyoxyethylene ether 2%, fatty alcohol polyoxyethylene ether phosphate 2%, tristyrene-phenylphenol polyoxyethylene ether polyoxypropylene ether 3%, sodium polycarboxylate 1%, silicone oil 0.4%, magnesium aluminum silicate 1%, sodium sorbate 0.2%, xanthan gum 0.3%, glycerol 5%, deionized water to make up the balance.

[0060] Preparation method: Water, dispersant and wetting agent are mixed evenly. Defoamer and antifreeze are added in sequence under stirring. The mixture is then mixed evenly by high-speed shearing. Feneptamidoquin and cyazofamid are added and shearing is continued. The mixture is then ground in a horizontal sand mill to control the particle size of the material to be below 90% of 5μm. Finally, a thickener is added and sheared evenly to obtain the suspension of the present invention.

[0061] Preparation Example 5: 18% feneptamidoquin·cyprodinil wettable powder (1:8) (2% + 16%)

[0062] Formula composition: feneptamidoquin 2%, cymoxanil 16%, sodium dodecyl sulfate 2%, dispersant NNO 5%, sodium lignosulfonate 5%, silica 3%, kaolin to make up the balance.

[0063] Preparation method: The active ingredient feneptamidoquin is mixed with cyazofamid, dispersant, wetting agent and filler, stirred evenly in a stirring tank, and then pulverized and mixed evenly multiple times by an air jet mill to prepare the wettable powder of the composition of the present invention.

[0064] Preparation Example 6: 32% feneptamidoquin·cyprodinil water-dispersible granules (3:1) (24% + 8%)

[0065] Formula composition: feneptamidoquin 24%, cymoxanil 8%, naphthalene sulfonate formaldehyde condensate 10%, sodium lignosulfonate 5%, sodium dodecyl sulfate 4%, diatomaceous earth 5%, kaolin to make up the balance.

[0066] Preparation method: The active ingredients feneptamidoquin and cytosyl acetamiprid are added to the carrier, along with surfactants and other functional additives. The mixture is then pulverized by air jet milling, and 10-25% water is added. The mixture is then kneaded, granulated, dried, and sieved to obtain the water-dispersible granule product.

[0067] Example 1: Indoor Bioactivity Assay of Botrytis cinerea

[0068] Test basis: The test refers to NY / T 1156.2-2006 "Guidelines for Indoor Bioassay of Pesticides - Fungicides Part 2: Plate Method for Inhibition of Mycelial Growth of Pathogenic Fungi" and NY / T 1156.6-2006 "Guidelines for Indoor Bioassay of Pesticides - Fungicides Part 6: Determination of Combined Effects of Mixtures".

[0069] Experimental target: Botrytis cinerea Pers.

[0070] Test agents: feneptamidoquin technical grade, fluopyram technical grade, and cyazofamid technical grade.

[0071] Preparation of the drug: First, dissolve the above raw materials in a suitable solvent, then dissolve them in a 0.1% Tween-80 aqueous solution. Set the required series of mass concentrations according to the drug activity.

[0072] Drug preparation: Under aseptic conditions, according to the experimental setup, quantitatively add pre-melted sterile culture medium to a sterile conical flask. Add the drug solution quantitatively from low to high concentration sequentially to the sterile conical flask, and shake thoroughly. Then pour equal volumes into 9cm diameter petri dishes to prepare drug-containing plates of the corresponding concentration.

[0073] Inoculation: Using a sterile punch, create mycelial cakes from the edges of activated colonies. Inoculate these cakes using an inoculation loop into the center of PDA medium containing each drug concentration and the control. Incubate in a constant temperature incubator for 3–4 days. When the control colonies nearly cover the entire culture dish, measure the diameter of each colony using the cross-sectional method. Calculate the inhibition rate of each drug against *Botrytis cinerea*.

[0074] Data statistics and calculation methods: Based on the survey results, the inhibition rate of mycelial growth of the tested target bacteria at each treatment concentration was calculated using the following formula. Based on the logarithmic values ​​of each agent concentration and the corresponding inhibition probability values, a statistical analysis system was used to analyze the data and derive the virulence regression equation and EC50. 50 The values ​​and correlation coefficients are used to evaluate the activity of the test reagent on the biological sample.

[0075]

[0076] In the formula:

[0077] I—colony growth inhibition rate;

[0078] D0—Correlation diameter of the blank control;

[0079] D t —The diameter of colony growth after chemical treatment.

[0080] The co-toxicity coefficient (CTC) of the mixture was calculated using Sun Yunpei's method to evaluate the type of combined effects.

[0081] A CTC ≥ 120 indicates a synergistic effect, a CTC ≤ 80 indicates an antagonistic effect, and a CTC between 80 and 120 indicates an additive effect. The co-toxicity coefficient (CTC value) of the mixture is calculated using the following formula:

[0082]

[0083] In the formula:

[0084] ATI – Actual Measured Toxicity Index of Mixtures;

[0085] S – EC of standard bactericides 50 The unit is milligrams per liter (mg / L);

[0086] M – EC of the mixture 50 The unit is milligrams per liter (mg / L).

[0087] TTI = TIA *P A +TI B *P B

[0088] In the formula:

[0089] TTI – Theoretical Toxicity Index of Mixtures;

[0090] TI A —A. Toxicity index of drug A;

[0091] P A —Percentage content of drug A in the mixture, expressed as percentage (%);

[0092] TI B —Toxicity index of drug B;

[0093] P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0094]

[0095] In the formula:

[0096] CTC – Cotoxicity Coefficient;

[0097] ATI – Actual Measured Toxicity Index of Mixtures;

[0098] TTI – Theoretical Toxicity Index of Mixtures.

[0099] The results of the indoor tests are shown in the table below.

[0100] Table 1. Indoor bioactivity test of feneptamidoquin combined with fluopyram against cucumber gray mold.

[0101]

[0102]

[0103] The results of the combined indoor toxicity test in the table above show that fluopyram has high toxicity against Botrytis cinerea, with an EC50 value of [missing information]. 50The concentration was 0.3539 mg / L. When the mass ratio of feneptamidoquin to fluopyram was 1:25–30:1, it showed good control of Botrytis cinerea, with a synergistic or additive effect and no antagonism. When the mass ratio was 1:20–30:1, the co-toxicity coefficient was greater than 120, indicating a synergistic effect. When the mass ratio was 1:15–25:1, the co-toxicity coefficient was greater than 130, showing a significant synergistic effect. When the mass ratio was 1:10–18:1, the co-toxicity coefficient was greater than 140, showing a significant synergistic effect. The highest co-toxicity coefficient (183.226) was observed at a mass ratio of 5:1, indicating that the combined activity of feneptamidoquin and fluopyram against Botrytis cinerea was optimal at this ratio.

[0104] Table 2. Indoor bioactivity test of feneptamidoquin and cetirizine combination against cucumber gray mold.

[0105] Test reagents virulence regression equation Correlation coefficient R <![CDATA[EC 50 (mg.L -1 )]]> Cotoxicity coefficient feneptamidoquin(A) y = 1.2719x + 4.2022 0.9993 4.2390 - Boscalid (B) y = 1.2586x + 4.4414 0.9955 2.7787 - A:B(1:27) y = 1.4283x + 4.5096 0.9894 2.2047 127.605 A:B(1:15) y = 1.4922x + 4.5449 0.9934 2.0183 140.705 A:B(1:8) y = 1.4558x + 4.6329 0.9912 1.7872 161.666 A:B(1:5) y = 1.3987x + 4.6733 0.9906 1.7122 172.174 A:B(1:3) y = 1.3879x + 4.7325 0.9964 1.5586 195.083 A:B(3:1) y = 1.3028x + 4.6453 0.9971 1.8718 200.168 A:B(5:1) y = 1.3290x + 4.5337 0.9961 2.2431 173.760 A:B(12:1) y = 1.4759x + 4.3794 0.9939 2.6332 154.728 A:B(21:1) y = 1.3717x + 4.2643 0.9974 3.4379 120.425 A:B(24:1) y = 1.3285x + 4.1909 0.9930 4.0645 102.146 A:B(30:1) y = 1.3230x + 4.1469 0.9995 4.4143 94.428

[0106] The results of the combined indoor toxicity test in the table above show that boscalid has high toxicity against Botrytis cinerea, with an EC50 value of [missing information]. 50 The concentration was 2.7787 mg / L. When the mass ratio of feneptamidoquin to boscalid was 1:27–30:1, it showed good control of Botrytis cinerea, with a synergistic or additive effect and no antagonism. When the mass ratio was 1:27–21:1, the co-toxicity coefficient was greater than 120, indicating a synergistic effect. When the mass ratio was 1:15–12:1, the co-toxicity coefficient was greater than 150, showing a significant synergistic effect. When the mass ratio was 1:8–5:1, the co-toxicity coefficient was greater than 160, showing a prominent synergistic effect. The highest co-toxicity coefficient (200.168) was observed at a mass ratio of 3:1, indicating that the combined activity of feneptamidoquin and boscalid against Botrytis cinerea was the best at this ratio.

[0107] Example 2: Field efficacy trial of pesticide for controlling cucumber gray mold

[0108] Experimental location: The experiment was conducted in a cucumber greenhouse in Sanguanmiao Village, Pulandian City, Dalian, Liaoning Province. The soil fertility of the experimental site was moderate, and the cultivation management of each experimental plot was relatively uniform.

[0109] Experimental crop: Cucumber (Xintai Dense Thorn).

[0110] Experimental subject: gray mold of cucumber (Botrytis cinerea). Gray mold was prevalent and uniform in all experimental plots.

[0111] Experimental treatments: The experiment consisted of 8 treatments, each repeated 4 times, with a plot area of ​​20m². 2 .

[0112] Application method: The experiment used a backpack sprayer with a fan-shaped nozzle, manufactured by Singapore Linong, and sprayed at a pressure of 1 atmosphere. The first application was made at the initial stage of cucumber gray mold infection, followed by a second application 7 days later, for a total of two applications.

[0113] Experimental method: Fixed-point survey was conducted in each plot, with 30 plants surveyed per plot and all fruits of each plant surveyed. Disease incidence was investigated 7 days after the first application and 10 days after the second application, and the diseased fruits and disease severity were recorded.

[0114] Grading method for cucumber fruit damage (by fruit):

[0115] Grade 0: No lesions;

[0116] Level 1: Disease occurs in residual flowers;

[0117] Grade 3: Disease occurs at the fruit's blossom end;

[0118] Grade 5: Lesions covering less than 10% of the fruit;

[0119] Grade 7: Lesions cover 11% to 25% of the fruit.

[0120] Grade 9: The length of the lesion accounts for more than 26% of the fruit.

[0121]

[0122] The field efficacy trials are shown in the table below:

[0123] Table 3 Results of field efficacy trials for controlling cucumber gray mold

[0124]

[0125]

[0126] The results in the table above show that the rational combination of feneptamidoquin with fluopyram or boscalid has excellent control efficacy against cucumber gray mold, significantly better than the control effects of single agents of 300 g / L fluopyram suspension, 50% boscalid water-dispersible granules, and 25% feneptamidoquin suspension. After two applications, the control efficacy of the combined formulation was 87.40%, 83.00%, 90.27%, and 87.27%, respectively. The tested agents at the applied dosages had no adverse effects on the growth and fruit set of cucumber plants.

[0127] Indoor toxicity tests and field efficacy tests show that the fungicidal composition of the present invention exhibits good control effect against cucumber gray mold, is safe for crops, delays the development of drug resistance in pathogens, and reduces the dosage of the agent while reducing the pesticide residue in agricultural products.

[0128] Although the present invention has been described in detail above with general description and specific embodiments, some modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A bactericidal composition containing feneptamidoquin, characterized in that, The bactericidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is feneptamidoquin and active ingredient B is either fluopyram or cymoxanil. The active ingredient B is fluopyram, and the mass ratio of active ingredient A to active ingredient B is 1:20~30:1; The active ingredient B is cyazofamid, and the mass ratio of active ingredient A to active ingredient B is 1:27~21:

1.

2. The bactericidal composition according to claim 1, characterized in that, The active ingredient B is fluopyram, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 25:

1. The active ingredient B is cyazofamid, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 12:

1.

3. The bactericidal composition according to claim 1, characterized in that, The total weight of the bactericidal composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 0.1% to 80% of the total weight of the bactericidal composition.

4. The bactericidal composition according to claim 1, characterized in that, The total weight of the bactericidal composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 1% to 70% of the total weight of the bactericidal composition.

5. The bactericidal composition according to claim 1, characterized in that, In addition to the active ingredient, the bactericidal composition also includes agriculturally permitted auxiliary ingredients, which are selected from one or more of the following: wetting agents, dispersants, thickeners, disintegrants, emulsifiers, defoamers, preservatives, stabilizers, synergists, carriers, and solvents.

6. The bactericidal composition according to claim 1, characterized in that, The bactericidal composition is prepared into any agriculturally permissible formulation.

7. The bactericidal composition according to claim 6, characterized in that, The dosage form is a solid dosage form or a liquid dosage form; the solid dosage form is a wettable powder or a water-dispersible granule, and the liquid dosage form is a suspension or an emulsifiable concentrate.

8. The application of the fungicidal composition according to any one of claims 1-7 in the control of fungal diseases of plants, characterized in that, The aforementioned plant fungal disease, gray mold.

9. The application according to claim 8, characterized in that, The bactericidal composition is applied in an effective dose to the disease or its growth medium that needs to be controlled.

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