Traditional Chinese medicine composition for treating glaucoma and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating glaucoma and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 5 to 15 parts of fructus lycii, 2 to 10 parts of flos chrysanthemi, 5 to 15 parts of radix rehmanniae recen, 2 to 10 parts of fructus corni, 5 to 15 parts of rhizoma dioscoreae, 5 to 15 parts of poria cocos, 2 to 10 parts of cortex moutan, 2 to 10 parts of salted rhizoma alismatis, 2 to 10 parts of lucid ganoderma, 2 to 10 parts of fried fructus broussonetiae and 2 to 10 parts of rhizoma acori graminei. The traditional Chinese medicine composition has the effects of nourishing kidney and liver, nourishing yin and promoting salivation, clearing liver and improving vision, and promoting qi circulation and inducing diuresis, and is used for treating blurred vision, eye swelling and pain and uncomfortable eyes caused by glaucoma.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine preparations, and in particular to a Chinese medicine composition for treating glaucoma and a preparation method thereof. Background Art

[0002] Glaucoma is a disease characterized by characteristic optic atrophy and visual field loss. It is the second leading cause of blindness in the world after cataracts, and the leading irreversible blinding eye disease in the world. By 2040, the number of glaucoma patients worldwide is expected to increase to 111.8 million, with glaucoma patients in Asia accounting for 60% of the world's total. China is the country with the most glaucoma in the world, with 1 / 6 of the world's glaucoma patients in China. It is estimated that 3.1 million people will become blind by 2050.

[0003] At present, Western medicine treatment of glaucoma mainly focuses on lowering intraocular pressure to preserve the patient's existing visual function, but even if the patient's intraocular pressure is controlled in a variety of ways, the visual function of some patients will further deteriorate. Foreign studies have confirmed that if the intraocular pressure is simply controlled within the normal range for a long time, one-third of patients will still have further damage to their visual function and continuous visual acuity decline, so simply controlling intraocular pressure is not a completely effective treatment method. Glaucoma patients have an urgent need for visual function rehabilitation, and the prevention and treatment of optic nerve damage has also become a hot topic in glaucoma treatment research in recent years. Although Western medicine stem cell therapy is expected to become a means of visual function rehabilitation for glaucoma, there is still no clinical research report with sufficient evidence and definite efficacy, and there are still problems such as operational safety, tumorigenicity and immune rejection in the treatment of glaucoma with stem cell transplantation that have not been solved. Therefore, Western medicine treatment can only reduce intraocular pressure at present, and there is no better way to reverse the damaged optic nerve structure and restore visual function. When facing chronic diseases such as glaucoma, traditional Chinese medicine provides a path for comprehensive conditioning of chronic diseases of glaucoma and visual function rehabilitation with its unique theories, methods and advantages.

[0004] Since the main pathological basis of glaucoma is the degeneration and apoptosis of retinal ganglion cells (RGCs), the current focus of glaucoma treatment is to protect RGCs. With the continuous deepening of research on traditional Chinese medicine, there have been many new advances in the protection of visual RGCs. Pharmacological studies in recent years have shown that traditional Chinese medicine has a protective effect on visual function, and its unique advantage is that it can perform multi-pathway and multi-target holistic intervention on various blinding eye diseases. Studies have found that traditional Chinese medicine can protect RGCs, improve the vision and visual field of glaucoma patients, and has high safety and few side effects; it can control optic nerve atrophy, improve human microcirculation; enhance the body's antioxidant capacity, promote blood circulation and remove blood stasis; promote blood circulation in the eye and protect the optic nerve. In addition, studies have found that estrogen has the effect of lowering intraocular pressure and protecting the optic nerve. At the same time, it is believed that some traditional Chinese medicines with the effect of nourishing kidney yin are similar to estrogen to some extent and have a protective effect on the optic nerve. The above research results are highly consistent with the understanding of traditional Chinese medicine on the etiology and pathogenesis of glaucoma.

[0005] Traditional Chinese medicine believes that glaucoma belongs to the category of "five wind cataracts", and the visual function damage of glaucoma belongs to the category of "amyopia". "Zhengzhi Zhunsheng·Miscellaneous Diseases·Qiqiaomen" says: "For amyopia, the pupil is neither big nor small, without any defects or damage. If you look carefully, there is no different color in the pupil, just like a healthy person, but you can't see, which is the symptom. If there is any color, it is cataract, not amyopia." Amyopia is optic nerve atrophy in Western medicine, and it is also the final pathological manifestation of glaucoma. Professor Chen Dafu, a famous modern ophthalmologist, proposed to combine the six meridians of Treatise on Febrile Diseases with ophthalmology in "Six Meridians Essentials". He believed that the retina belongs to the liver meridian of foot Jueyin, and the pupil is a water wheel, which corresponds to the kidney. The liver and kidney have the same origin, and Yi and Gui have the same origin, so the disease is closely related to the liver and kidney. The etiology and pathogenesis are mostly caused by factors such as wind, fire, phlegm, depression, and deficiency, which lead to disharmony of qi and blood, qi stagnation and blood stasis, causing blockage of the eye palace and stagnation of aqueous humor. After a long period of illness, the liver and kidney will be deficient, water will not contain wood, and the divine light will be weakened, resulting in "aberranoid blindness". It can be seen that liver and kidney deficiency and vascular stasis run through the entire process of glaucoma pathological changes and are the main pathogenesis of glaucoma visual function damage. Therefore, nourishing the liver and kidney and promoting blood circulation and removing blood stasis are the basic treatment principles for optic nerve damage in glaucoma.

[0006] However, there are very few Chinese patent medicines on the market that can clearly treat glaucoma, which cannot provide more options for clinicians and patients. Summary of the invention

[0007] In order to solve the above technical problems, the purpose of the present invention is to provide a Chinese medicine composition for the treatment of glaucoma and a preparation method thereof. The Chinese medicine composition nourishes the kidney and liver, nourishes yin and produces body fluid, clears the liver and improves eyesight, promotes qi and promotes diuresis, and is used for blurred vision, eye swelling and pain, and eye discomfort caused by glaucoma.

[0008] The technical solution of the present invention to solve the above technical problems is as follows: a traditional Chinese medicine composition for treating glaucoma is provided, comprising the following components in parts by weight: 5-15 parts of wolfberry, 2-10 parts of chrysanthemum, 5-15 parts of raw rehmannia, 2-10 parts of cornus, 5-15 parts of yam, 5-15 parts of poria, 2-10 parts of peony bark, 2-10 parts of salt alisma, 2-10 parts of ganoderma lucidum, 2-10 parts of stir-fried paper mulberry fruit and 2-10 parts of calamus.

[0009] Furthermore, the Chinese medicine composition for treating glaucoma comprises the following components in parts by weight: 8-12 parts of wolfberry, 4-8 parts of chrysanthemum, 8-12 parts of raw rehmannia, 4-8 parts of cornus, 8-12 parts of yam, 8-12 parts of poria, 4-8 parts of peony bark, 4-8 parts of salt alisma, 4-8 parts of ganoderma lucidum, 4-8 parts of stir-fried paper mulberry fruit and 4-8 parts of calamus.

[0010] Furthermore, a Chinese medicine composition for treating glaucoma comprises the following components in parts by weight: 10 parts of wolfberry, 6 parts of chrysanthemum, 10 parts of raw rehmannia, 6 parts of cornus, 10 parts of yam, 10 parts of poria, 6 parts of peony bark, 6 parts of salt alisma, 6 parts of ganoderma lucidum, 6 parts of stir-fried paper mulberry fruit and 6 parts of calamus.

[0011] The preparation method of the above-mentioned Chinese medicine composition for treating glaucoma adopts the traditional Chinese medicine preparation method to prepare it into an oral dosage form.

[0012] Furthermore, the dosage form is tablet, granule, decoction, capsule or pill.

[0013] The present invention has the following beneficial effects:

[0014] 1. The Chinese medicine composition of the present invention nourishes the kidney and liver, nourishes yin and produces body fluid, clears the liver and improves eyesight, and promotes qi and diuresis. It is used for blurred vision, eye swelling and pain, and discomfort in the eyes caused by glaucoma, providing more TCM treatment options for clinical physicians and patients. The prescription is more streamlined, with only 11 herbs, which reduces the risk of sensitization and gastrointestinal burden. In terms of efficacy, it not only nourishes the liver and kidney more specifically, clears the liver and improves eyesight, but also strengthens the function of promoting qi and diuresis, further helping glaucoma patients to reduce intraocular pressure.

[0015] 2. In the Chinese medicine composition of the present invention, Rehmannia root is the main drug, and its main function is to nourish the liver and kidney, replenish essence and benefit the marrow; Cornus officinalis and Chinese yam assist in nourishing the liver and kidney, and consolidating the essence; Rhizoma Alismatis, Cortex Moutan, and Poria cocos can eliminate dampness and turbidity, and harmonize the medicinal properties; Fructus Lycii and Chrysanthemum mainly nourish the liver and kidney, clear the liver and improve eyesight. In addition, Acorus tatarinowii is used to promote qi and diuresis, and reduce intraocular pressure; Fructus Cuscutae can clear the liver and improve eyesight, nourish the kidney and promote diuresis, and Acorus tatarinowii is used to strengthen diuresis and reduce intraocular pressure; Finally, Ganoderma lucidum is used to replenish qi and calm the mind, relieve anxiety and insomnia symptoms of glaucoma patients, and can also enhance the overall tonic effect. The entire prescription is targeted at the etiology and pathogenesis of glaucoma, and has the characteristics of simplified medication and synergistic compatibility.

[0016] 3. The Chinese medicine composition of the present invention selects raw Rehmannia root instead of cooked Rehmannia root. Raw Rehmannia root also has the merit of nourishing liver, kidney and yin of cooked Rehmannia root, and does not nourish the spleen, and will not damage the stomach and intestines due to the greasy texture. Containing Ganoderma lucidum can replenish qi and calm the mind, relieve the anxiety and insomnia symptoms of glaucoma patients, and Ganoderma lucidum is sweet and flat in nature, which can enhance the overall tonic merit. Modern pharmacological research has found that the components such as polysaccharides and polypeptides in Ganoderma lucidum can regulate immune function, promote the synthesis of nucleic acids and proteins, and resist free radicals, thereby delaying aging. Ganoderma lucidum has a protective effect on liver damage, promotes liver metabolism of drugs and poisons, alleviates liver damage, and protects liver function. Ganoderma lucidum suppresses hyperactive immune levels and prevents allergic reactions. It can also improve microcirculation disorders, have a good antihypertensive effect on patients with refractory hypertension, and is suitable for glaucoma patients with combined hypertension (blood pressure and intraocular pressure have a positive correlation). Containing Acorus calamus can strengthen the merit of promoting qi and promoting diuresis, and promote qi and promote diuresis to reduce intraocular pressure. DETAILED DESCRIPTION

[0017] The principles and features of the present invention are described below, and the examples are only used to explain the present invention and are not used to limit the scope of the present invention. If no specific conditions are specified in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments is not specified, they are all conventional products that can be purchased commercially.

[0018] Example 1

[0019] A Chinese medicine composition for treating glaucoma comprises the following components in parts by weight: 5 parts of wolfberry, 2 parts of chrysanthemum, 5 parts of raw rehmannia, 2 parts of cornus, 5 parts of yam, 5 parts of tuckahoe, 2 parts of peony bark, 2 parts of salt alisma, 2 parts of ganoderma lucidum, 2 parts of stir-fried mulberry fruit and 2 parts of calamus.

[0020] Example 2

[0021] A Chinese medicine composition for treating glaucoma comprises the following components in parts by weight: 10 parts of wolfberry, 6 parts of chrysanthemum, 10 parts of raw rehmannia, 6 parts of cornus, 10 parts of yam, 10 parts of poria, 6 parts of peony bark, 6 parts of salt alisma, 6 parts of ganoderma lucidum, 6 parts of stir-fried mulberry fruit and 6 parts of calamus.

[0022] Example 3

[0023] A Chinese medicine composition for treating glaucoma comprises the following components in parts by weight: 15 parts of wolfberry, 10 parts of chrysanthemum, 15 parts of raw rehmannia, 10 parts of cornus, 15 parts of yam, 15 parts of tuckahoe, 10 parts of peony bark, 10 parts of salt alisma, 10 parts of ganoderma lucidum, 10 parts of stir-fried mulberry fruit and 10 parts of calamus.

[0024] The Chinese medicine composition for treating glaucoma of Example 2 is currently being taken by more than 200 glaucoma patients. Retrospective clinical observation study: 72 eyes of patients with stable intraocular pressure after anti-glaucoma surgery, taking Chinese medicine for ≥3 months and complete reexamination data were screened, with an average age of 57.24±18.32 years. The results of the comparative analysis of objective auxiliary examination indicators before and after treatment are shown in Table 1.

[0025] Table 1 Comparison of observation indicators before and after treatment (n=72)

[0026]

[0027] As shown in Table 1, the differences in visual acuity, retinal nerve fiber layer thickness, upper and lower peridiscal capillary density, and visual field before and after treatment were statistically significant (P < 0.05). The results show that the Chinese medicine composition for treating glaucoma of the present invention can improve the visual function and optic nerve blood supply of glaucoma patients and delay the progression of visual field.

[0028] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating glaucoma, characterized in that: The invention comprises the following components in parts by weight: 5-15 parts of wolfberry, 2-10 parts of chrysanthemum, 5-15 parts of raw rehmannia, 2-10 parts of cornus, 5-15 parts of yam, 5-15 parts of poria, 2-10 parts of peony bark, 2-10 parts of salt alisma, 2-10 parts of ganoderma lucidum, 2-10 parts of stir-fried mulberry fruit and 2-10 parts of calamus.

2. The Chinese medicine composition for treating glaucoma according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 8-12 parts of wolfberry, 4-8 parts of chrysanthemum, 8-12 parts of raw rehmannia, 4-8 parts of cornus, 8-12 parts of yam, 8-12 parts of poria, 4-8 parts of peony bark, 4-8 parts of salt alisma, 4-8 parts of ganoderma lucidum, 4-8 parts of stir-fried mulberry fruit and 4-8 parts of calamus.

3. The Chinese medicine composition for treating glaucoma according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 10 parts of wolfberry, 6 parts of chrysanthemum, 10 parts of raw rehmannia root, 6 parts of cornus officinalis, 10 parts of yam, 10 parts of tuckahoe, 6 parts of peony bark, 6 parts of salt alisma orientalis, 6 parts of ganoderma lucidum, 6 parts of stir-fried mulberry fruit and 6 parts of calamus.

4. The method for preparing the Chinese medicine composition for treating glaucoma according to any one of claims 1 to 3, characterized in that: The oral dosage form is prepared by traditional Chinese medicine preparation method.

5. The method for preparing the Chinese medicine composition for treating glaucoma according to claim 4, characterized in that: The dosage form is tablet, granule, decoction, capsule or pill.

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