Genetic molecular marker related to auxiliary diagnosis of colorectal cancer of multiple humans and application of genetic molecular marker
By screening and verifying GWAS data from multi-ethnic populations, genetic molecular markers related to colorectal cancer were identified and weighted multi-gene risk score model was constructed, which solved the problem of low prediction effectiveness in Chinese populations, and achieved effective prediction and individualized prevention of colorectal cancer risk in multi-ethnic populations.
CN119736389APending Publication Date: 2025-04-01NANJING MEDICAL UNIV
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Patent Information
- Application Number
- CN202411692334.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-25
- Publication Date
- 2025-04-01
AI Technical Summary
Technical Problem
The existing genetic models have low prediction effectiveness in Chinese populations and cannot effectively exert the effect of genetic prediction models.
Method used
By screening GWAS data from East Asian and European and American populations, combining external data verification, reliable genetic molecular markers for colorectal cancer assisted diagnosis were identified, and a weighted multigene risk score model was constructed to predict the risk of multiracial colorectal cancer.
Benefits of technology
It has achieved effective prediction of the risk of colorectal cancer in multiracial populations, provided a basis for individualized prevention and treatment decision-making, and improved the sensitivity and specificity of diagnosis.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a genetic molecular marker related to colorectal cancer auxiliary diagnosis and application of the genetic molecular marker, and belongs to the field of genetic engineering and oncology. 37 SNPs significantly related to the colorectal cancer onset risk are screened out, the colorectal cancer auxiliary diagnosis kit prepared based on 37 markers is helpful for clinicians to rapidly master the genetic risk of colorectal cancer onset, powerful support is provided for early prevention measures, and the colorectal cancer auxiliary diagnosis kit is suitable for multiple populations and has a wide application prospect. The problem that a conventional genetic risk prediction model is not compatible with people in China and Europe and America is effectively solved.
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