Traditional Chinese medicine for preventing and treating cardiomyopathy and preparation method thereof

Abstract

The invention relates to the technical field of cardiomyopathy prevention and treatment, and discloses a traditional Chinese medicine for preventing and treating cardiomyopathy. The traditional Chinese medicine is prepared by mixing a composite traditional Chinese medicine extract and auxiliary materials. The composite traditional Chinese medicine extract comprises the following components: 10-15 parts of salvia miltiorrhiza, 10-15 parts of chuanxiong rhizome, 3-5 parts of red peony root, 6-8 parts of achyranthes bidentata, 3-5 parts of bamboo leaf, 10-15 parts of scutellaria baicalensis, 8-12 parts of kudzu root, 8-12 parts of astragalus, 4-6 parts of rhodiola rosea, 8-12 parts of ginkgo leaves, 3-5 parts of schisandra chinensis, 8-12 parts of bupleurum, 5-8 parts of green peel, 7-10 parts of turmeric, 10-15 parts of motherwort and 3-5 parts of betel nut. The invention also discloses a treatment method of preventing and treating cardiomyopathy with traditional Chinese medicine, comprising the following steps: S1, crushing the traditional Chinese medicine raw materials; S2, soaking the composite traditional Chinese medicine powder; S3, decocting the soaking residue; S4, concentrating the filtrate; and S5, adding auxiliary materials. The present invention can significantly improve the symptoms of palpitations, fatigue, dizziness, chest tightness and shortness of breath in patients with hypertrophic cardiomyopathy, and has a significant effect on the prevention and treatment of hypertrophic cardiomyopathy.

Description

Technical Field

[0001] The present invention relates to the technical field of cardiomyopathy prevention and treatment, in particular to a traditional Chinese medicine for preventing and treating cardiomyopathy and a preparation method thereof. Background Art

[0002] Cardiomyopathy is a group of heterogeneous myocardial diseases, which are caused by abnormal mechanical and electrical activity of the heart due to different causes, manifested as inappropriate ventricular hypertrophy or dilation; severe cardiomyopathy can cause cardiovascular death or progressive heart failure; cardiomyopathy is usually divided into primary cardiomyopathy and secondary cardiomyopathy, among which primary cardiomyopathy includes dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and unclassified cardiomyopathy; while hypertrophic cardiomyopathy is an idiopathic cardiomyopathy with familial heart abnormalities, characterized by asymmetric myocardial hypertrophy, obstructed left ventricular filling, and decreased left ventricular diastolic compliance as the basic pathological myocardial disease.

[0003] At present, hypertrophic cardiomyopathy can generally be treated by taking beta-blockers, but beta-blockers may cause bradycardia, syncope, increased airway resistance, induce shortness of breath, and aggravate symptoms such as bronchial asthma or chronic obstructive pulmonary disease. Therefore, traditional Chinese medicine preparations for the prevention and treatment of cardiomyopathy have emerged.

[0004] For example, a Chinese patent discloses a traditional Chinese medicine compound preparation for treating cardiomyopathy (authorization announcement number CN117379503A). This patented technology can improve the clinical efficacy and cardiac function of patients with dilated cardiomyopathy, effectively alleviate myocardial fibrosis and ventricular remodeling, and further improve the efficacy of traditional Chinese medicine in treating dilated cardiomyopathy. However, its efficacy for hypertrophic cardiomyopathy is poor. Summary of the Invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine for preventing and treating cardiomyopathy and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine for preventing and treating cardiomyopathy, which is prepared by mixing a compound traditional Chinese medicine extract and excipients, wherein the compound traditional Chinese medicine extract is extracted from the following traditional Chinese medicine raw material components in parts by mass:

[0008] 10-15 parts of Salvia miltiorrhiza, 10-15 parts of Chuanxiong, 3-5 parts of Red Peony Root, 6-8 parts of Achyranthes bidentata, 3-5 parts of Bambusa chinensis, 10-15 parts of Scutellaria baicalensis, 8-12 parts of Pueraria lobata, 8-12 parts of Astragalus membranaceus, 4-6 parts of Rhodiola rosea, 8-12 parts of Ginkgo biloba, 3-5 parts of Schisandra chinensis, 8-12 parts of Bupleurum chinense, 5-8 parts of Citrus aurantium, 7-10 parts of Curcuma longa, 10-15 parts of Leonurus japonicus and 3-5 parts of Areca catechu.

[0009] As a further solution of the present invention: the auxiliary materials are composed of the following parts by mass: 3 to 5 parts of edible alcohol, 5 to 8 parts of flavoring agents and 0.5 to 0.8 parts of sorbic acid.

[0010] As a further embodiment of the present invention, the flavoring agent is one or more of aromatic syrup, stevioside and honey.

[0011] A method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy comprises the following steps:

[0012] S1. Take 10-15 parts of Danshen, 10-15 parts of Chuanxiong, 3-5 parts of Red Peony Root, 6-8 parts of Achyranthes, 3-5 parts of Bamboo Leaf, 10-15 parts of Scutellaria, 8-12 parts of Pueraria, 8-12 parts of Astragalus, 4-6 parts of Rhodiola, 8-12 parts of Ginkgo Leaf, 3-5 parts of Schisandra, 8-12 parts of Bupleurum, 5-8 parts of Citrus aurantium, 7-10 parts of Curcuma, 10-15 parts of Leonurus and 3-5 parts of Areca, clean them, dry them, crush them into powder respectively, and mix them to obtain a composite Chinese medicine powder;

[0013] S2, soaking the compound Chinese medicine powder in warm water until the warm water covers the top of the compound Chinese medicine powder; filtering to obtain the soaking liquid and soaking residue for later use;

[0014] S3, adding 10 to 15 times the weight of distilled water to the soaked residue in step S2, boiling, and then simmering for 2 to 3 hours, filtering to obtain a primary filtrate and a primary filter residue for standby use; adding 8 to 10 times the weight of distilled water to the primary filter residue, boiling, and then simmering for 1.5 to 2 hours, filtering to obtain a secondary filtrate and a secondary filter residue;

[0015] S4, combining the soaking liquid in step S2 and the primary filtrate and the secondary filtrate in step S3, and concentrating under reduced pressure to obtain a composite Chinese medicine extract;

[0016] S5. Add 3-5 parts of edible alcohol, 5-8 parts of flavoring agents and 0.5-0.8 parts of sorbic acid to the compound Chinese herbal extract, heat and stir continuously to fully dissolve it, then cool to room temperature and fill it. The patient drinks it orally, once in the morning and evening, each time taking 3-5 ml.

[0017] As a further solution of the present invention: in the step S2, the temperature of the warm water is 40-50°C, and the soaking time is 3-4 hours.

[0018] As a further solution of the present invention: in the step S4, the temperature for reduced pressure concentration is 60-70°C, the vacuum degree is 0.07-0.09 MPa, and the density after concentration is 1.08-1.12 g / ml.

[0019] As a further solution of the present invention: in the step S5, the heating temperature is 60-70°C, and the stirring rate is 1200-1500 r / min.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The traditional Chinese medicine prepared by the present invention is prepared by mixing compound traditional Chinese medicine extracts and auxiliary materials, wherein the compound traditional Chinese medicine extracts are extracted from salvia miltiorrhiza, chuanxiong, red peony root, achyranthes bidentata, bamboo leaf, scutellaria baicalensis, kudzu root, astragalus, rhodiola rosea, ginkgo leaf, schisandra chinensis, bupleurum, green peel, turmeric, motherwort and betel nut. The traditional Chinese medicine can significantly improve the symptoms of palpitations, fatigue, dizziness, chest tightness and shortness of breath in patients with hypertrophic cardiomyopathy, reduce myocardial hypertrophy, and has significant effects on the prevention and treatment of hypertrophic cardiomyopathy. DETAILED DESCRIPTION

[0022] Example 1: In the embodiment of the present invention, a traditional Chinese medicine for preventing and treating cardiomyopathy is prepared by mixing a compound traditional Chinese medicine extract and an auxiliary material. The compound traditional Chinese medicine extract is extracted from the following traditional Chinese medicine raw material components by weight:

[0023] 10 parts of Danshen, 10 parts of Chuanxiong, 3 parts of Red Peony Root, 6 parts of Achyranthes, 3 parts of Bamboo Leaf, 10 parts of Scutellaria, 8 parts of Pueraria, 8 parts of Astragalus, 4 parts of Rhodiola, 8 parts of Ginkgo Leaf, 3 parts of Schisandra, 8 parts of Bupleurum, 5 parts of Citrus aurantium, 7 parts of Curcuma, 10 parts of Leonurus, and 3 parts of Areca;

[0024] The auxiliary materials are composed of 3 parts of edible alcohol, 5 parts of aromatic syrup and 0.5 parts of sorbic acid.

[0025] A method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy comprises the following steps:

[0026] S1. Take 10 parts of Danshen, 10 parts of Chuanxiong, 3 parts of Red Peony Root, 6 parts of Achyranthes, 3 parts of Bamboo Leaf, 10 parts of Scutellaria, 8 parts of Pueraria, 8 parts of Astragalus, 4 parts of Rhodiola, 8 parts of Ginkgo Leaf, 3 parts of Schisandra, 8 parts of Bupleurum, 5 parts of Citrus aurantium, 7 parts of Curcuma, 10 parts of Leonurus and 3 parts of Areca, wash them clean, dry them, crush them into powder respectively, and mix them to obtain a composite Chinese medicine powder;

[0027] S2, placing the compound Chinese medicine powder into 40° C. warm water, so that the warm water covers the top of the compound Chinese medicine powder, and soaking for 4 hours; filtering to obtain the soaking liquid and soaking residue for later use;

[0028] S3, adding 10 times the weight of distilled water to the soaked residue in step S2, boiling, and then simmering for 2 hours, filtering to obtain a primary filtrate and a primary filter residue for standby use; adding 8 times the weight of distilled water to the primary filter residue, boiling, and then simmering for 1.5 hours, filtering to obtain a secondary filtrate and a secondary filter residue;

[0029] S4, combining the soaking liquid in step S2 and the primary filtrate and the secondary filtrate in step S3, and concentrating under reduced pressure at a temperature of 60° C. and a vacuum degree of 0.09 MPa to a density of 1.08 g / ml to obtain a composite Chinese herbal extract;

[0030] S5. Add 3 parts of edible alcohol, 5 parts of aromatic syrup and 0.5 parts of sorbic acid to the compound Chinese herbal extract, heat to 60°C, and stir continuously at a rate of 1500r / min to fully dissolve it, then cool to room temperature and fill it.

[0031] Example 2: In the embodiment of the present invention, a traditional Chinese medicine for preventing and treating cardiomyopathy is prepared by mixing a compound traditional Chinese medicine extract and an auxiliary material. The compound traditional Chinese medicine extract is extracted from the following traditional Chinese medicine raw material components by weight:

[0032] 12 parts of Danshen, 12 parts of Chuanxiong, 4 parts of Red Peony Root, 7 parts of Achyranthes, 4 parts of Bamboo Leaf, 12 parts of Scutellaria, 10 parts of Pueraria, 10 parts of Astragalus, 5 parts of Rhodiola, 10 parts of Ginkgo Leaf, 4 parts of Schisandra, 10 parts of Bupleurum, 6 parts of Citrus aurantium, 8 parts of Curcuma, 12 parts of Leonurus, and 4 parts of Areca;

[0033] The auxiliary materials are composed of the following by mass: 4 parts of edible alcohol, 6 parts of stevioside and 0.6 parts of sorbic acid.

[0034] A method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy comprises the following steps:

[0035] S1. Take 12 parts of Danshen, 12 parts of Chuanxiong, 4 parts of Red Peony Root, 7 parts of Achyranthes, 4 parts of Bamboo Leaf, 12 parts of Scutellaria, 10 parts of Pueraria, 10 parts of Astragalus, 5 parts of Rhodiola, 10 parts of Ginkgo Leaf, 4 parts of Schisandra, 10 parts of Bupleurum, 6 parts of Citrus aurantium, 8 parts of Curcuma, 12 parts of Leonurus and 4 parts of Areca, wash them clean, dry them, crush them into powder respectively, and mix them to obtain a composite Chinese medicine powder;

[0036] S2. Place the compound Chinese medicine powder in 45° C. warm water, so that the warm water covers the top of the compound Chinese medicine powder, and soak for 3.5 hours; filter to obtain the soaking liquid and soaking residue for later use;

[0037] S3, adding 12 times the weight of distilled water to the soaked residue in step S2, boiling, and then simmering for 2.5 hours, filtering to obtain a primary filtrate and a primary filter residue for standby use; adding 9 times the weight of distilled water to the primary filter residue, boiling, and then simmering for 1.5 to 2 hours, filtering to obtain a secondary filtrate and a secondary filter residue;

[0038] S4, combining the soaking liquid in step S2 and the primary filtrate and the secondary filtrate in step S3, and concentrating under reduced pressure at a temperature of 65° C. and a vacuum degree of 0.08 MPa to a density of 1.10 g / ml to obtain a composite Chinese herbal extract;

[0039] S5. Add 4 parts of edible alcohol, 6 parts of stevioside and 0.6 parts of sorbic acid to the compound Chinese herbal extract, heat to 65°C, and stir continuously at a rate of 1350 r / min to fully dissolve it, then cool to room temperature and fill it.

[0040] Example 3: In the embodiment of the present invention, a traditional Chinese medicine for preventing and treating cardiomyopathy is prepared by mixing a compound traditional Chinese medicine extract and an auxiliary material. The compound traditional Chinese medicine extract is extracted from the following traditional Chinese medicine raw material components in parts by mass:

[0041] 15 parts of Danshen, 15 parts of Chuanxiong, 5 parts of Red Peony Root, 8 parts of Achyranthes, 5 parts of Bamboo Leaf, 15 parts of Scutellaria, 12 parts of Pueraria, 12 parts of Astragalus, 6 parts of Rhodiola, 12 parts of Ginkgo Leaf, 5 parts of Schisandra, 12 parts of Bupleurum, 8 parts of Citrus aurantium, 10 parts of Curcuma, 15 parts of Leonurus, and 5 parts of Areca;

[0042] The auxiliary materials are composed of the following by mass: 5 parts of edible alcohol, 8 parts of honey and 0.8 parts of sorbic acid.

[0043] A method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy comprises the following steps:

[0044] S1. Take 15 parts of Danshen, 15 parts of Chuanxiong, 5 parts of Red Peony Root, 8 parts of Achyranthes, 5 parts of Bamboo Leaf, 15 parts of Scutellaria, 12 parts of Pueraria, 12 parts of Astragalus, 6 parts of Rhodiola, 12 parts of Ginkgo Leaf, 5 parts of Schisandra, 12 parts of Bupleurum, 8 parts of Citrus Aurantii, 10 parts of Curcuma, 15 parts of Leonurus and 5 parts of Areca, clean them, dry them, crush them into powder respectively, and mix them to obtain a composite Chinese medicine powder;

[0045] S2, placing the compound Chinese medicine powder into 50°C warm water, so that the warm water covers the top of the compound Chinese medicine powder, and soaking for 3 hours; filtering to obtain the soaking liquid and soaking residue for later use;

[0046] S3, adding 15 times the weight of distilled water to the soaked residue in step S2, boiling, and then simmering for 3 hours, filtering to obtain a primary filtrate and a primary filter residue for standby use; adding 10 times the weight of distilled water to the primary filter residue, boiling, and then simmering for 2 hours, filtering to obtain a secondary filtrate and a secondary filter residue;

[0047] S4, combining the soaking liquid in step S2 and the primary filtrate and the secondary filtrate in step S3, and concentrating under reduced pressure at a temperature of 70° C. and a vacuum degree of 0.07 MPa to a density of 1.12 g / ml to obtain a composite Chinese herbal extract;

[0048] S5. Add 5 parts of edible alcohol, 8 parts of honey and 0.8 parts of sorbic acid to the compound Chinese herbal extract, heat to 70°C, and stir continuously at a rate of 1200 r / min to fully dissolve it, then cool to room temperature and fill it.

[0049] In order to better illustrate the technical effects of the present invention, the following embodiments are described:

[0050] For patients who have visited the hospital for a period of time and have experienced varying degrees of palpitations, fatigue, dizziness, chest tightness and shortness of breath, and whose condition worsens after exertion, they are diagnosed with hypertrophic cardiomyopathy through clinical, electrocardiographic and echocardiographic examinations. The main characteristics are myocardial hypertrophy and ventricular cavity shrinkage.

[0051] 140 patients were randomly selected from these patients, including 78 male patients and 72 female patients; the patients' disease course ranged from 7 months to 12 years, with an average of 4.2 years; the patients' age ranged from 18 to 69 years, with an average of 42.5 years; these patients were randomly divided into four groups, namely, Example 1 to 3 groups and a control group, with 35 patients in each group;

[0052] The patients in groups 1 to 3 of Examples 1 to 3 took the Chinese medicine prepared in Examples 1 to 3, respectively. Each patient took it once in the morning and evening, 4 ml each time. The patients in the control group did not take any medicine. After 2 weeks, the clinical symptoms, echocardiograms, and electrocardiograms of the patients in each group were detected, and the efficacy was evaluated and recorded in Table 1 below.

[0053] Among them, in clinical symptoms, marked effect is manifested as: palpitations, fatigue, dizziness, chest tightness and shortness of breath are significantly improved; effective effect is manifested as: palpitations, fatigue, dizziness, chest tightness and shortness of breath are improved; ineffective effect is manifested as: palpitations, fatigue, dizziness, chest tightness and shortness of breath are not significantly improved or are aggravated;

[0054] In echocardiography, marked effect is manifested as: myocardial hypertrophy is significantly improved; effective effect is manifested as: myocardial hypertrophy is improved; ineffective effect is manifested as: myocardial hypertrophy is not significantly improved or is aggravated;

[0055] Electrocardiogram showed: markedly effective: ST-T significantly improved; effective: ST-T improved; ineffective: ST-T no significant improvement;

[0056] Table 1 Analysis of changes in indicators in patients with cardiomyopathy

[0057]

[0058] From Table 1 above, it can be concluded that the clinical symptoms, echocardiographic and electrocardiographic test results in the Example 1-3 groups and the control group were basically the same, thus concluding that the test results of each group in this experiment were accurate; among them, the symptoms of the patients in the control group did not show any improvement; while the sum of the markedly effective and effective rates of the patients in the Example 1-3 groups exceeded 80%; furthermore, it can be concluded that the traditional Chinese medicine prepared by the present invention can significantly improve the symptoms of palpitations, fatigue, dizziness, chest tightness and shortness of breath in patients with hypertrophic cardiomyopathy, reduce myocardial hypertrophy, and has a significant effect on the prevention and treatment of hypertrophic cardiomyopathy.

[0059] The above is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with this technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solutions and inventive concepts of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A Chinese medicine for preventing and treating cardiomyopathy, which is prepared by mixing a compound Chinese medicine extract and an auxiliary material, characterized in that: The compound Chinese medicine extract is extracted from the following Chinese medicine raw material components in parts by mass: 10-15 parts of Salvia miltiorrhiza, 10-15 parts of Chuanxiong, 3-5 parts of Red Peony Root, 6-8 parts of Achyranthes bidentata, 3-5 parts of Bambusa chinensis, 10-15 parts of Scutellaria baicalensis, 8-12 parts of Pueraria lobata, 8-12 parts of Astragalus membranaceus, 4-6 parts of Rhodiola rosea, 8-12 parts of Ginkgo biloba, 3-5 parts of Schisandra chinensis, 8-12 parts of Bupleurum chinense, 5-8 parts of Citrus aurantium, 7-10 parts of Curcuma longa, 10-15 parts of Leonurus japonicus and 3-5 parts of Areca catechu.

2. A Chinese medicine for preventing and treating cardiomyopathy according to claim 1, characterized in that: The auxiliary materials are composed of the following parts by mass: 3 to 5 parts of edible alcohol, 5 to 8 parts of flavoring agents and 0.5 to 0.8 parts of sorbic acid.

3. A Chinese medicine for preventing and treating cardiomyopathy according to claim 2, characterized in that: The flavoring agent is one or more of aromatic syrup, stevioside and honey.

4. A method for preparing the Chinese medicine for preventing and treating cardiomyopathy according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Take 10-15 parts of Danshen, 10-15 parts of Chuanxiong, 3-5 parts of Red Peony Root, 6-8 parts of Achyranthes, 3-5 parts of Bamboo Leaf, 10-15 parts of Scutellaria, 8-12 parts of Pueraria, 8-12 parts of Astragalus, 4-6 parts of Rhodiola, 8-12 parts of Ginkgo Leaf, 3-5 parts of Schisandra, 8-12 parts of Bupleurum, 5-8 parts of Citrus aurantium, 7-10 parts of Curcuma, 10-15 parts of Leonurus and 3-5 parts of Areca, clean them, dry them, crush them into powder respectively, and mix them to obtain a composite Chinese medicine powder; S2, soaking the compound Chinese medicine powder in warm water until the warm water covers the top of the compound Chinese medicine powder; filtering to obtain the soaking liquid and soaking residue for later use; S3, adding 10 to 15 times the weight of distilled water to the soaked residue in step S2, boiling, and then simmering for 2 to 3 hours, filtering to obtain a primary filtrate and a primary filter residue for standby use; adding 8 to 10 times the weight of distilled water to the primary filter residue, boiling, and then simmering for 1.5 to 2 hours, filtering to obtain a secondary filtrate and a secondary filter residue; S4, combining the soaking liquid in step S2 and the primary filtrate and the secondary filtrate in step S3, and concentrating under reduced pressure to obtain a composite Chinese medicine extract; S5. Add 3-5 parts of edible alcohol, 5-8 parts of flavoring agents and 0.5-0.8 parts of sorbic acid to the compound Chinese herbal extract, heat and stir continuously to fully dissolve it, then cool to room temperature and fill it.

5. The method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy according to claim 4, characterized in that: In the step S2, the temperature of the warm water is 40-50° C., and the soaking time is 3-4 hours.

6. The method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy according to claim 4, characterized in that: In the step S4, the temperature for reduced pressure concentration is 60-70° C., the vacuum degree is 0.07-0.09 MPa, and the density after concentration is 1.08-1.12 g / ml.

7. The method for preparing a traditional Chinese medicine for preventing and treating cardiomyopathy according to claim 4, characterized in that: In the step S5, the heating temperature is 60-70° C., and the stirring rate is 1200-1500 r / min.

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