Traditional Chinese medicine preparation for treating herpangina and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine preparation for treating herpangina and a preparation method thereof.The traditional Chinese medicine preparation is prepared from semen cuscutae, dandelion, radix ophiopogonis, radix rehmanniae and fructus forsythiae according to a preset weight part proportion, dandelion is a ministerial drug for clearing away heat and toxic materials and relieving swelling and removing stasis; the radix ophiopogonis is used as an adjuvant drug and can nourish yin and moisten dryness and relieve heat toxin consumption; the radix rehmanniae and the fructus forsythiae are conductant drugs and are used for guiding the drugs to channel, so that the drug effect is improved and concentrated in the oral pharyngeal lesion area. The traditional Chinese medicine preparation can be prepared into multiple external dosage forms such as cream, powder and spray, is simple and convenient to operate, mild and safe, and can effectively relieve symptoms such as fever, pain, blister and ulcer caused by oral herpes. The invention further provides a preparation method of the external dosage form of the traditional Chinese medicine preparation, the advantages of mild conditioning and simultaneous treatment of principal and subordinate symptoms of traditional Chinese medicine are utilized, the blank of external medicine for herpangina in the current market is filled, and the traditional Chinese medicine preparation has good practicability and popularization and application prospects.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating herpangina and a preparation method thereof. Background Art

[0002] Herpangina is one of the common acute viral infectious diseases in children, characterized by fast transmission speed, strong infectivity, and obvious course of disease. Its pathogenesis usually includes four stages: incubation period, prodromal period, vesicular stage, and ulcer stage. Children do not immediately have a fever at the initial stage of infection. Generally, clinical symptoms gradually appear within 3 - 5 days after infection.

[0003] In the prodromal period, children often have symptoms such as high fever and sore throat. The body temperature can quickly rise above 38.5°C, accompanied by obvious discomfort. After entering the vesicular stage, red small vesicles appear in the oral cavity, pharynx, and palate of children. In some children with severe conditions, small vesicles can even be seen widely distributed in the entire oral cavity. In the subsequent ulcer stage, the vesicles rupture to form ulcer surfaces, and children show manifestations such as refusal to eat, drooling, and restlessness due to pain, seriously affecting nutritional intake and the recovery process.

[0004] Currently, there is still a lack of drugs with strong specificity and definite therapeutic effects for the intervention of herpangina in children in clinical practice. Especially in vast grass - roots areas, medical resources are relatively scarce, and often rely on physical antipyretic and local care and other means for symptomatic treatment, lacking a systematic and compound effective treatment plan. In addition, the antiviral treatment with western medicine has poor tolerance and relatively more side effects in children, further restricting its wide application.

[0005] Therefore, taking advantage of the advantages of traditional Chinese medicine resources in our country and giving full play to the advantages of traditional Chinese medicine in "syndrome differentiation and treatment" and "overall conditioning", developing a safe, effective, good - palatability, and easily acceptable traditional Chinese medicine composition for children has very important practical significance and application value for relieving the symptoms of herpangina, shortening the course of disease, and reducing recurrence. Summary of the Invention

[0006] In view of the above-mentioned technical problems, a traditional Chinese medicine preparation for treating herpangina, its preparation method and application are provided. The traditional Chinese medicine preparation of the present invention mainly adopts the compatibility principle of "sovereign, minister, assistant, and courier". As a whole, it focuses on "tonifying the kidney and nourishing yin, clearing heat and detoxifying, promoting the production of body fluid and moistening dryness", and is used to relieve or treat oral mucosal lesions caused by hyperactivity of fire due to yin deficiency and upward disturbance of heat-toxicity in children, such as herpangina. Among them, dodder seeds are the "sovereign" drug, which can strengthen the kidney and consolidate the root, enhance the vital qi, and prevent the recurrence of herpes; dandelion is the "minister" drug, which can clear heat and detoxify, and mainly treats the swelling, redness and burning pain of herpes caused by heat-toxicity; ophiopogon root is the "assistant" drug, which can nourish yin and promote the production of body fluid, and relieve the consumption of yin fluid caused by heat-toxicity; rehmannia root and forsythia are the "courier" drugs, which can conduct the drug to the meridian, harmonize the properties of the drug, and enhance the directivity of the drug effect on the upper jiao (oral cavity). This compatibility structure coordinates cold and heat, takes into account both root deficiency and superficial excess, and reflects the overall concept of traditional Chinese medicine syndrome differentiation and treatment and the systematic thinking of treating herpes.

[0007] The technical means adopted in the present invention are as follows:

[0008] A traditional Chinese medicine preparation for treating herpangina, which is formulated according to the compatibility principle of sovereign, minister, assistant, and courier, and comprises the following Chinese medicine raw materials in parts by weight:

[0009] 80-95 parts of dodder seeds;

[0010] 5-10 parts of dandelion;

[0011] 5-15 parts of ophiopogon root;

[0012] 5-10 parts of rehmannia root;

[0013] Among them, dodder seeds are the sovereign drug, which can nourish the kidney and essence, and strengthen the healthy qi and consolidate the root; dandelion is the minister drug, which can clear heat and detoxify, and dissipate swelling and nodules; ophiopogon root is the assistant drug, which can nourish yin and moisten dryness, and moderate the properties of the drug; rehmannia root is the courier drug, which can conduct the drug to the meridian, promote the ascending of clear qi and disperse heat, and synergistically guide the drug effect to act on the upper jiao lesion site.

[0014] The effective treatment ratio of the traditional Chinese medicine preparation with the above ratio is as high as 90-98.5%. It has outstanding and unexpected technical effects in the treatment fields of herpangina in children, oral simple herpes, varicella, hand-foot-and-mouth disease herpes, perianal herpes, and genital herpes in men and women.

[0015] Furthermore, calculated by weight parts, the traditional Chinese medicine preparation further comprises 5-10 parts of forsythia, and both the forsythia and the rehmannia root are courier drugs.

[0016] Furthermore, calculated by weight parts, the traditional Chinese medicine preparation comprises 85-90 parts of dodder seeds, 6-8 parts of dandelion, 8-10 parts of ophiopogon root, 6-8 parts of rehmannia root, and 7-9 parts of forsythia.

[0017] Furthermore, the traditional Chinese medicine preparation is an external preparation.

[0018] Further, the topical preparation includes one of cream, powder or spray.

[0019] The present invention also discloses an application of the above-mentioned traditional Chinese medicine preparation in the preparation of a drug for relieving or treating herpangina.

[0020] The present invention also discloses a preparation method of a spray for treating herpangina, and the preparation method includes the following steps:

[0021] 1) Mix the traditional Chinese medicine raw materials in the above-mentioned traditional Chinese medicine preparation according to the ratio and soak for 30 - 60 minutes; select high-quality, top-grade and best traditional Chinese medicine raw materials, and strictly screen the color, texture brightness, water content, whether there are insects, mildew, whether it is mixed with other drugs and the quality of the origin, etc. of the traditional Chinese medicine.

[0022] 2) Decoct the soaked traditional Chinese medicine raw materials with water, bring to a boil over high heat and then decoct over low heat for 20 - 30 minutes, then turn off the heat source to make a decoction. After filtering multiple times, it is filled into a sterile container and stored refrigerated for external spraying or smearing.

[0023] The present invention also discloses a preparation method of a powder for treating herpangina, and the preparation method includes the following steps:

[0024] 1) Stir-fry the dodder seed in the above-mentioned traditional Chinese medicine preparation until slightly yellowish, take it out and let it cool naturally, and mix it with other traditional Chinese medicine raw materials according to the ratio;

[0025] 2) Pour it into a traditional Chinese medicine pulverizer, grind it into powder, sieve and mix evenly, then fill it into a clean and sterile bottle for applying on the face.

[0026] Further, in step 2), a sieve with 800 - 1000 meshes is used for sieving to form an extremely fine powder. After sieving, stir evenly, store it sealed and keep it from getting damp, and store it at 0 - 10 °C for standby.

[0027] The present invention also discloses a preparation method of a cream for treating herpangina, and the preparation method includes the following steps:

[0028] 1) Stir-fry the dodder seed in the above-mentioned traditional Chinese medicine preparation until slightly yellowish, take it out and let it cool naturally, and mix it with other traditional Chinese medicine raw materials according to the ratio;

[0029] 2) Put the mixed raw materials into a pulverizer and pulverize them into fine powder, and sieve for standby;

[0030] 3) Take vegetable oil as the base material of the ointment, heat and melt it according to a certain ratio, and when it cools to 40 - 50 °C, add the medicinal powder obtained in step 2), and stir evenly to obtain the cream;

[0031] 4) Fill the cream into a clean and sterile container, seal it and store it for external application.

[0032] Preferably, the ratio of the base material to the medicinal powder is controlled between 3:1 and 5:1 to ensure spreadability and drug efficacy release. Trace amounts of preservatives (such as phenethyl alcohol) or natural antibacterial components (such as tea tree essential oil) can also be added to improve preservation.

[0033] The common pharmacological effects of the traditional Chinese medicine raw materials selected in the present invention are as follows:

[0034] Cuscuta chinensis: It is the fruit of a Convolvulaceae plant, represented by Cuscuta australis RB1- or the dried ripe seeds of Cuscuta chinensis Lam. It is pungent, sweet and neutral, and belongs to the stomach meridian. It can tonify the kidney and consolidate essence, nourish the liver and improve eyesight, secure the fetus and soothe the mind, support yang and assist yin, tonify the liver and kidney, strengthen yang and stop diarrhea, and is used for male impotence and spermatorrhea, diarrhea, soreness and weakness of the waist and knees, tinnitus and kidney deficiency. The core compatibility of the present invention is "tonifying the kidney and strengthening the healthy qi, nourishing yin and regulating harmony". As the monarch drug, Cuscuta chinensis plays the role of "tonifying the root", and the monarch drug establishes the basic direction of the prescription of "mainly tonifying and taking warming and nourishing as the key link".

[0035] Taraxacum mongolicum: It is cold in nature and sweet in taste, and has the effects of clearing heat and detoxifying, dispersing swelling and dissipating carbuncles. It is used for sores, boils and carbuncles, mastitis, urinary tract infections, acute and chronic tonsillitis. Although it is a heat-clearing product, its nature is mild, and it has a clear anti-inflammatory and detoxifying effect. As the minister drug, Taraxacum mongolicum specifically targets pathological products such as "heat toxin, deficiency heat, and chronic inflammation", and effectively cooperates with the monarch drug to prevent the recurrence of "warming and nourishing generating heat" or "internal deficiency fire not cleared". Collaborating with Forsythia suspensa, it can clear the heat toxin of the lesion and shorten the duration of herpes.

[0036] Ophiopogon japonicus: Its nature and flavor are sweet, flat, cold and non-toxic. It can moisten the lungs and clear the heart, nourish the stomach and promote fluid production, and has the effects of relieving cough and clearing heat, dry mouth and throat, expectorant and cough-relieving, strengthening the heart and promoting diuresis. As an assistant drug, the function of Ophiopogon japonicus is to have clearing in moistening and no stagnation in tonifying. It helps to relieve the bitter and cold properties of Taraxacum mongolicum and Forsythia suspensa, and protects the stomach qi. At the same time, it also enhances the "yin-nourishing" aspect of Cuscuta chinensis, and is especially suitable for those with yin deficiency constitution accompanied by heat. It is the core compatibility drug with two-way synergy of "assisting the monarch and helping the minister", which improves the comfort of taking and the safety of long-term use.

[0037] Rehmannia glutinosa: It is cold in nature and bitter in taste, and can clear heat and cool blood, and is used for nourishing yin, injury to yin caused by febrile diseases, yin deficiency fever, hyperactivity of heart fire, mouth sores, sore throat, diphtheria, diabetes, etc. As a guiding drug, it enhances the guiding effect of the whole prescription on the heart, kidney and blood aspect, especially guiding the yin-nourishing power of Ophiopogon japonicus and Cuscuta chinensis into the syndrome of heart and kidney yin deficiency; at the same time, it can reconcile the cold-heat contradiction between the warming and nourishing drugs and the heat-clearing drugs.

[0038] Forsythia suspensa: The mature fruit of Forsythia suspensa in the Oleaceae family, sweet and cool, with the functions of clearing heat and detoxifying, dissipating swelling and nodules, treating sore throat, carbuncles and sores, scrofula. It is rich in phillyrin, vitamin P saponins and a small amount of volatile oil, and has a strong inhibitory effect on a variety of viruses and bacteria. It has a certain therapeutic effect on allergic purpura and urinary tract infections, and some people also use it for infectious diseases such as viral hepatitis. As an envoy drug in this prescription: First, it synergizes with dandelion to enhance the function of detoxifying and dissipating nodules, and guides heat-clearing drugs to reach the triple energizer, dredging collaterals and expelling pathogenic factors; Second, it enhances the ascending trend of the medicinal qi, promoting the overall medicinal effect to penetrate to the diseased area; Third, its property of "lifting the clear yang" helps the effect of the whole prescription to spread throughout the upper and lower parts, playing the role of "guiding the drug upward".

[0039] Compared with the prior art, the present invention has the following advantages:

[0040] 1. Based on the theory of traditional Chinese medicine syndrome differentiation, through the precise compatibility of monarch, minister, assistant and envoy, the present invention takes overall consideration of "deficiency of the root" and "excess of the superficiality", treating both the symptoms and the root causes simultaneously;

[0041] 2. The selected drugs of the present invention have mild properties and high safety, and are suitable for children by using the mild conditioning of traditional Chinese medicine.

[0042] 3. The present invention can be flexibly prepared into various dosage forms. The external administration method avoids gastrointestinal irritation, has the characteristics of rapid onset and direct local action, and is especially suitable for the simple operation in areas with poor grass-roots medical conditions.

[0043] In summary, the various external dosage forms prepared from the traditional Chinese medicine preparation provided by the present invention are suitable for children, are simple to operate, mild, safe, can effectively relieve symptoms such as fever, pain, blisters and ulcers caused by oral herpes, and are expected to shorten the course of disease, relieve the pain of children and improve the quality of life. The present invention fills the blank of external drugs for children with herpangina in the current market and has good practicability and application prospects. Description of the Drawings

[0044] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0045] Figure 1 It is a picture of the oral herpes of the child in Case 1.

[0046] Figure 2 It is a picture of the oral cavity of the child in Case 1 after recovery. Detailed Embodiments

[0047] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0048] Example 1

[0049] This example provides a traditional Chinese medicine preparation for treating herpangina in children. The traditional Chinese medicine preparation includes raw materials: 850 g of dodder seeds, 5 g of dandelion, 10 g of ophiopogon root, 10 g of rehmannia root, and 10 g of forsythia.

[0050] The above-mentioned traditional Chinese medicine preparation in the given amounts is made into a medicinal liquid according to the following steps. The specific steps are as follows:

[0051] 1) By weight, put dodder seeds (fried), dandelion, ophiopogon root, rehmannia root, and forsythia into a clean earthenware pot, iron pot, or aluminum pot, add 300 ml (purified water) for soaking, and the soaking time is 30 - 60 minutes.

[0052] 2) Decoct the above-mentioned soaked traditional Chinese medicine raw materials with water. Bring to a boil over high heat and then simmer for 20 - 30 minutes, then turn off the heat source to make a decoction. Then filter out the medicinal liquid with a filter basket or sterile gauze. After cooling, place the medicinal liquid in a sterile container, and then filter the filtered traditional Chinese medicine medicinal liquid again with sterile gauze. After completion, pour it into a clean glass or a clean plastic bottle, seal it well, and store it in the refrigerator for later use, for external spraying or smearing.

[0053] Example 2

[0054] This example provides a traditional Chinese medicine preparation for treating herpangina in children. The traditional Chinese medicine raw materials include: 80 g of dodder seeds, 8 g of dandelion, 10 g of ophiopogon root, 8 g of forsythia, and 8 g of rehmannia root. It is made into a spray, and the preparation steps are the same as those in Example 1.

[0055] Example 3

[0056] This example provides a traditional Chinese medicine preparation for treating herpangina in children. The traditional Chinese medicine raw materials include: 90 g of dodder seeds, 10 g of dandelion, 15 g of ophiopogon root, 8 g of forsythia, and 8 g of rehmannia root. It is made into a traditional Chinese medicine cream. The specific preparation method is as follows:

[0057] 1) Fry the dodder seeds in the above-mentioned traditional Chinese medicine raw materials until slightly yellowish, take them out and let them cool naturally, and mix them with other traditional Chinese medicine raw materials according to the ratio;

[0058] 2) Put the mixed raw materials into a pulverizer and pulverize them into fine powder, and sieve them for later use;

[0059] 3) Take vegetable oil as the base material of the ointment. After heating and melting it according to the ratio of the base material to the medicinal powder controlled at 4:1, when it is cooled to 40 - 50 °C, add the medicinal powder obtained in step 2), and stir well to obtain a cream; a small amount of preservative (such as phenethyl alcohol) or natural antibacterial component (such as tea tree essential oil) can also be added to improve the preservation property;

[0060] 4) Put the cream into a clean and sterile container, seal it for storage, and use it for external application. The cream is suitable for oral herpes.

[0061] Example 4

[0062] This example provides a traditional Chinese medicine preparation for treating herpangina in children. The traditional Chinese medicine raw materials include: 90 g of dodder seeds, 5 g of dandelion, 10 g of ophiopogon root, 10 g of rehmannia root, and 10 g of forsythia. Make it into a traditional Chinese medicine powder. The specific steps are as follows:

[0063] 1) Stir-fry the dodder seeds until slightly yellowish by weight, take them out and let them cool naturally, and mix them with other traditional Chinese medicine raw materials according to the ratio.

[0064] 2) Pour it into a traditional Chinese medicine grinder, grind it into flour, use a very fine sieve bottom (800 - 1000 meshes), sieve it into a very fine powder, stir well after sieving, put it into a clean and sterile bottle, seal it tightly for storage, and it must not be exposed to moisture. Store it at 0 - 10 °C for later use.

[0065] For treating herpangina in children, it can be applied externally.

[0066] Comparative Example 1 (without ophiopogon root)

[0067] Weigh 80 g of dodder seeds, 10 g of rehmannia root, 10 g of forsythia, and 5 g of dandelion. The steps for making the traditional Chinese medicine preparation are the same as those in Example 1.

[0068] Comparative Example 2 (without dodder seeds)

[0069] Weigh 10 g of ophiopogon root, 10 g of rehmannia root, 10 g of forsythia, and 10 g of dandelion. The steps for making the traditional Chinese medicine preparation are the same as those in Example 1.

[0070] Comparative Example 3 (without rehmannia root)

[0071] Weigh 15 g of ophiopogon root, 80 g of dodder seeds, 10 g of forsythia, and 10 g of dandelion. The steps for making the traditional Chinese medicine preparation are the same as those in Example 1.

[0072] Analysis of treatment effects:

[0073] In the process of exploring the experimental effects of different formulations, the inventor used the drugs in the comparative examples and the examples before and after, and treated children with the formulations. Through the treatment effect analysis of the traditional Chinese medicine preparation of the present invention on more than twenty children with herpangina in the clinic, comparing the changes in the conditions of children in each group after 7 days of treatment with different example formulations, the results after statistical analysis are shown in Table 1 below.

[0074] Among them:

[0075] Cure means that the pain or fever of herpangina in children is completely relieved.

[0076] Marked effect means the degree of treatment effect of herpangina in children, that is, the pain and fever are significantly reduced. The treatment of herpes erythema and ulcers has changed for the better, about more than 30%.

[0077] Ineffective means that the curative effect of herpangina in children is very little, the condition has not improved, the marked effect degree of herpes erythema or ulcer is below 30%, and the pain and fever have not been relieved.

[0078] Table 1

[0079] Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Number of patients 25 25 25 25 25 25 25 Number of cured patients 17 19 15 23 11 0 20 Number of markedly effective patients 6 3 5 1 10 11 4 Number of ineffective patients 2 3 5 1 4 14 1 Total number of effective patients 92％ 88％ 80％ 96％ 84％ 44％ 96％

[0080] The inventor found in clinical practice that after the cure of herpangina in children, symptoms such as fever, sore throat, and discomfort are basically eliminated. After a few more days of recovery, it is completely cured without any postherpetic neuralgia or itching pain.

[0081] From the above experimental results, it can be seen that the traditional Chinese medicine preparation of the present invention has a simple preparation method. By making it into external preparations, powders, sprays, and creams can be directly sprayed on the affected area. It has a high cure rate for herpangina in children, has a quick effect, and is not easy to relapse. The traditional Chinese medicine preparation of the present invention has the effect of directly killing herpes virus on herpes virus, and other drugs have not been found to have the function of killing herpes virus clinically.

[0082] In summary, the inventor found in many years of clinical treatment practice observations that the traditional Chinese medicine preparation, its formulation, and preparation of the present invention are currently the special traditional Chinese medicine preparations for treating herpangina herpes, and have unexpected treatment effects on herpangina in children and chickenpox.

[0083] Treatment process of typical cases:

[0084] Using the traditional Chinese medicine preparation ratio of Example 4 of the present invention, dozens of children with herpangina herpes in the oral cavity of children were clinically treated and observed, and satisfactory treatment effects were obtained for all patients. The case treatment process is as follows:

[0085] Case 1

[0086] Gao XX, female, 3 years old, from Zhoukou City. She came to this clinic for treatment in October 2024. After inquiry and detailed examination, she was diagnosed with herpangina in children, complicated with oral ulcers (as Figure 1 shown). The mother of the child reported that her daughter had been treated in other clinics for 4 - 5 days. The child cried incessantly, refused to eat, was restless, drooled, and had a low fever. Due to the ineffective treatment in the previous few days and the worsening condition of the child, she came to this clinic for medical treatment. Since the cause of the disease is relatively complex as described above, treatment for the child was carefully started on the same day.

[0087] Treatment process of herpangina in children:

[0088] (1) First, let the child sit in the arms of his / her family member facing the doctor, assume a good sitting position, and tilt the head slightly upward.

[0089] (2) Let the child open his / her mouth. The doctor uses sterile forceps to hold a cotton ball and cleans the child's oral cavity with physiological saline. The technique should be gentle, steady, and attention should also be paid to the child's uneasiness.

[0090] (3) After cleaning the child's oral cavity with physiological saline, the traditional Chinese medicine preparation spray or powder of the present invention can be directly applied in the child's oral cavity. (Note: Even if the child eats it and swallows it into the stomach, there is no problem because this is traditional Chinese medicine powder, non-toxic and without side effects, so there is no need to worry the family members of the child.) It can be sprinkled in the child's oral cavity 4 - 5 times a day, 1 - 2 grams each time. If using the traditional Chinese medicine spray, it can be directly sprayed into the child's oral cavity. The dose should not be too large, just spray 1 - 2 times. The liquid medicine can be sprayed 5 - 6 times a day. However, infection must be prevented. If there are no systemic symptoms (such as fever, cough, and the child being listless), hospitalization and infusion are not required. The family members of the child should be told to come for a follow-up visit the next day. The child's diet should be light, drink more water, and eat fruits and the like. Avoid spicy, fried, and raw and cold foods, etc.

[0091] (4) If the effective treatment techniques and methods are not applied to the child's oral cavity, it will cause symptoms such as oral ulcers in children, swelling, redness, pain, and itching in the throat, and fever, seriously affecting the physical and mental health of young children.

[0092] (5) Instruct the family members of the child to pay attention to the child's diet, sleep, condition, mental state, and treatment effect.

[0093] (6) After 2 days of medication treatment, when coming to this clinic for a follow-up visit again, it can be seen that the mental state of the child is significantly better. Ask the family members of the child about the treatment effect. They described the specific situation after taking the medicine: Judging from the treatment situation after taking the medicine on time this time, the herpangina in the child's oral cavity has improved significantly. The child has basically stopped crying, has eaten much better, and the mental state has also improved a lot. The treatment effect is very good.

[0094] (7) After a second careful examination, it was found that the symptoms of the child's oral herpes and herpangina, such as the initial swelling, ulcers, and erythema, had significantly changed (as shown in Figure 2 ), and it continued to improve. Thus, it can be seen that the traditional Chinese medicine preparation of the present invention is worthy of recognition in the treatment of children's oral herpangina.

[0095] (8) After another week of careful treatment with the traditional Chinese medicine preparation of the present invention, the child was cured. It was learned from the follow-up that after a few days of recovery, the child had completely recovered and was normal in all aspects.

[0096] Case 2:

[0097] Liu ××, female, 4 years old, from Huaiyang District, Zhoukou City. She came to my clinic in October 2024. When she came, the child was listless, had a sore throat, did not have a fever, and did not want to eat. After a careful examination, she was diagnosed with children's oral herpangina, and was given careful treatment according to the following steps.

[0098] (1) Let the family members of the child hold the child firmly and sit on a chair. Let the child open his / her mouth. Use 0.9% sodium chloride (i.e., normal saline), cotton (medical sterile cotton), and forceps to clean the child's oral cavity. Note: The doctor's technique should be gentle, and attention should also be paid to the child's psychological emotions and limb movements to minimize crying. The oral herpes must be cleaned thoroughly.

[0099] (2) After cleaning the child's oral cavity, start using the traditional Chinese medicine powder, spray, or paste of the present invention (note that the two drug preparations can also be used alternately or alone). The traditional Chinese medicine spray can be directly sprayed on the child's oral cavity and the herpangina area for treatment. It can be sprayed several times a day (5 - 10 times). If the powder is used to treat children's oral herpangina, the same method can be used (i.e., applying the powder in the child's oral cavity), 5 - 6 times a day.

[0100] Children's oral herpangina is one of the most common infectious diseases in young children. It is highly contagious and spreads rapidly. Once children's oral herpangina is detected, early isolation and early treatment should be carried out. At present, in the medical field, no specific drugs for this specialty have been developed, and it is basically blank in the treatment of children's oral herpangina. Therefore, the traditional Chinese medicine preparation and the preparation method of its external preparation proposed by the present invention have broad market application value and typical significance.

[0101] The above embodiments are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A Chinese medicine preparation for treating herpetic pharyngitis, characterized in that: The Chinese medicine preparation is formulated according to the principle of monarch, minister, assistant and guiding compatibility, and includes the following Chinese medicine raw materials in parts by weight: 80-95 parts of Cuscuta seeds; 5-10 portions of dandelions; 5-15 portions of Ophiopogon japonicus; 5-10 portions of raw land; Among them, Cuscuta australis is the main medicine, which nourishes the kidney and essence, strengthens the body; Taraxacum mongolicum is the ministerial medicine, which clears away heat, detoxifies, reduces swelling and disperses nodules; Ophiopogon japonicus is the adjuvant medicine, which nourishes yin and moistens dryness, and moderates the properties of the medicine; Rehmannia glutinosa is the guiding medicine, which leads the medicine to the meridians, raises the clear and penetrates the heat, and synergistically guides the medicinal effects to act on the lesions in the upper part of the body.

2. The Chinese medicine preparation according to claim 1, characterized in that: The Chinese medicine preparation further comprises 5-10 parts of Forsythia suspensa by weight, and both the Forsythia suspensa and the Radix Rehmanniae are adjuvant drugs.

3. The Chinese medicine preparation according to claim 2, characterized in that: The traditional Chinese medicine preparation comprises 85-90 parts of Cuscuta seeds, 6-8 parts of Taraxacum mongolicum, 8-10 parts of Radix Ophiopogonis, 6-8 parts of Radix Rehmanniae, and 7-9 parts of Fructus Forsythiae by weight.

4. The Chinese medicine preparation according to claim 3, characterized in that: The Chinese medicine preparation is an external preparation.

5. The Chinese medicine preparation according to claim 4, characterized in that: The external preparation includes one of a cream, a powder or a spray.

6. Use of the traditional Chinese medicine preparation according to any one of claims 1 to 5 in the preparation of a medicament for alleviating or treating herpetic pharyngitis.

7. A method for preparing a spray for treating herpetic pharyngitis, characterized in that: The preparation method comprises the following steps: 1) Mix the Chinese medicinal materials in the Chinese medicinal preparation according to any one of claims 1 to 5 according to the proportion and soak for 30 to 60 minutes; 2) The soaked Chinese medicinal materials are decocted with water, brought to a boil over high heat, then simmered over low heat for 20-30 minutes, and then the heat is turned off to make a decoction. After multiple filtering, the decoction is put into a sterile container and stored in a refrigerator for external spraying or application.

8. A method for preparing a powder for treating herpetic pharyngitis, characterized in that: The preparation method comprises the following steps: 1) frying the dodder seeds in the traditional Chinese medicine preparation according to any one of claims 1 to 5 until light yellow, taking out and cooling naturally, and mixing with other traditional Chinese medicine raw materials according to a proportion; 2) Pour into a Chinese medicine grinder, grind into powder, sieve and mix well, then put into a clean and sterile bottle for making dough.

9. The preparation method according to claim 8, characterized in that: In the step 2), the sieve is sieved with a sieve bottom of 800-1000 mesh to form extremely fine flour. After sieving, the flour is stirred evenly, sealed and stored away from moisture, and stored at 0-10°C for later use.

10. A method for preparing a cream for treating herpetic pharyngitis, characterized in that: The preparation method comprises the following steps: 1) frying the dodder seeds in the traditional Chinese medicine preparation according to any one of claims 1 to 5 until light yellow, taking out and cooling naturally, and mixing with other traditional Chinese medicine raw materials according to a proportion; 2) Put the mixed raw materials into a grinder and grind them into fine powder, then sieve them for later use; 3) taking vegetable oil as an ointment base, heating and melting it in a certain proportion, cooling it to 40-50° C., adding the powder obtained in step 2), and stirring well to prepare an ointment; 4) Place the cream into a clean and sterile container and seal it for external application.

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